Structural Drug Design 2023: Biology, Chemistry and Computers

June 2 - June 10, 2023
Erice, Italy

The past two years have been transformational in showing how the medical and scientific communities can respond to acute health threats: the worldwide collaboration of scientists from all fields of biology, chemistry and structural sciences delivered results at previously unseen speed. Nevertheless, understanding and managing all aspects of human health remains one of society’s biggest challenges, and this in turn requires a robust understanding, currently still highly incomplete, of the underlying biology and healthy and diseased states. Structural information illuminates and accelerates all aspects of this drug design process, but the focus has remained decisively on the earlier stages, to providing tools for the understanding of the disease biology. Moreover, traditional structural biology techniques have now been thoroughly integrated with other disciplines, including biophysics, informatics, biology and chemistry. This continuous evolution means that success of the entire process depends on proper management of the increasing complexity, diversity and volume of data generated.

The purpose of the course is to provide the students with: a) an overview of the current structural and biophysical techniques used in the field; b) the use of informatics tools in drug discovery; c) the evolving role of chemistry in drug design and biology understanding; and d) an introduction to biologics and their applications. Several case studies will be presented to highlight the different topics. Hands-on workshops and tutorials will complement the lectures.

Registration for the 58th course of the International School of Crystallography, \"Structural Drug Design 2023: Biology, Chemistry and Computers” to be held in Erice (Italy), June 2-10, 2023 is now open!

For this Course the theme is integration of chemistry, biology, informatics and structural sciences to illuminate and accelerate all aspects of structure-based drug design. Several case studies will be presented to highlight the different topics, and hands-on workshops and tutorials will complement the lectures.

More information, including how to apply, grant support, registration form and tentative program, can be found at https://crystalerice.org/2023/.

The closing date for application is November 30, 2022

14th International Conference on Biology and Synchrotron Radiation

June 11 - June 14, 2023
AF Borgen, Lund, Sweden

International Biology and Synchrotron Radiation (BSR) meetings are held every three years with the aim of presenting and discussing state of the art application in relevant research fields.

They have a long-standing record since the first meeting in Frascari, Italy in 1986. Subsequent meetings were held at sites or near the most advanced light source facilities around the world, with the last BSR meeting taking place in Shanghai, China in 2019.

BSR is a unique forum to discuss the novel possibilities of synchrotron and X-rays lasers and to promote their application to challenging biological problems.

PSB Symposium on Dynamics in Structural Biology

July 6 - July 7, 2023
Grenoble, France

Since its inception, structural biology has sought more detail at ever-improved resolutions. Methodological developments have since allowed structural analyses of macromolecular assemblies of increasing size and complexity. However, in order to fully understand the mechanistics and dynamics of complex cellular machineries, it is of crucial importance to place these interdisciplinary results in an appropriate biological context using information from all resolution levels - from atomic detail to cellular and higher levels of organisation.

The fourth edition of the PSB biennial Symposium will focus on \" Dynamics in Structural Biology”, and the aim of this meeting is to illustrate how big biological questions can be resolved in structural biology through the application of interdisciplinary methodological approaches (including, but not limited to, cryo electron microscopy and tomography, NMR and EPR spectroscopy, X-ray serial crystallography at synchrotrons and XFELs, super resolution microscopy, MD simulations, atomic-force microscopy, and neutron and X-ray scattering methods), enhancing our understanding of the dynamic behaviour of macromolecules.

The registration to the PSB Symposium \"Dynamics in Structural Biology”, EPN Campus Grenoble, France on 6-7 July 2023, is open. https://www.esrf.fr/psbsymposium2023

The aim of this meeting is to illustrate how big biological questions can be resolved in structural biology through the application of interdisciplinary methodological approaches, enhancing our understanding of the dynamic behaviour of macromolecules.

Participants will have the possibility to present their own research in a poster session, and selected abstracts will be invited to give a short talk. (Deadline for abstract submission: 8 May 2023)

26TH CONGRESS AND GENERAL ASSEMBLY OF THE INTERNATIONAL UNION OF CRYSTALLOGRAPHY

August 22 - August 29, 2023
Melbourne Convention & Exhibition Centre, Australia

On behalf of the Local Organising Committee of the 26th Congress and General Assembly of the International Union of Crystallography and the Society of Crystallographers in Australia and New Zealand, we would like to extend our warmest invitation to you and your family to join us at the IUCr Congress in Melbourne, Australia from 22-29 August 2023.

British X-ray Crystallographers

October 18 - October 18, 2023
Conference Centre, The Royal Society of Chemistry, Burlington House, Piccadilly, London, W1J 0BA, United Kingdom

10.00 registration and coffee
10.30 Welcome by Peter Morris (organizer)
10.35 Opening remarks by Mike Glazer (chair of first session)
10.40 John Finney, Desmond Bernal
11.10 Jenny Wilson, Kathleen Lonsdale
11.40 Judith Howard, Dorothy Crowfoot Hodgkin
12.10 lunch
Judith Howard (chair of second session)
1.30 Elspeth Garmen, John Kendrew
2.00 Georgina Ferry, Max Perutz
2.30 Tom Blundell, David Phillips
3.00 tea
Peter Morris (chair of third session)
3.20 Stephen Neidle, Rosalind Franklin
3.50 Mike Glazer, Helen Megaw
4.20 Ian Wood, Judith Milledge
4.50 Peter Morris, Closing remarks
5.00 meeting ends

28th Enzyme Mechanisms Conference

January 3 - January 7, 2024
Naples Grande Beach Resort, Naples Florida, USA

Since it\'s inception in 1969, The Enzyme Mechanisms Conference has brought together academic and industrial scientists to discuss new ideas at the forefront of mechanistic enzymology. The goal is to foster collegial interactions among chemists and biochemists who seek to understand the chemical basis for enzymatic catalysis and regulation of enzyme action and those who apply that knowledge for practical applications.

The Enzyme Mechanisms Conferences have brought together academic and industrial scientists to discuss new ideas at the forefront of mechanistic enzymology. The goal is to foster collegial interactions among chemists and biochemists who seek to understand the chemical basis for enzymatic catalysis and regulation of enzyme action and those who apply that knowledge for practical applications.

The conference has been held biennially since it was founded in 1969 by Tom Bruice, Bill Jencks, and Myron Bender. Over the past 50+ years, the conference has provided an outstanding forum for the presentation and discussion of the most exciting advances in our understanding of the mechanisms of enzyme action and their application to pharmaceutical design and action and to plant health.

The 28th Enzyme Mechanisms Conference will be held in Naples, Florida January 3-7, 2024. The conference will begin with a reception Wednesday evening and conclude with a banquet Sunday evening. The General Sessions will be held during the mornings and evenings of Thursday and Friday and morning and afternoon on Saturday. Posters will be displayed the entire time with dedicated Poster Sessions in the afternoons and evening on Thursday and Friday. Graduate students and postdoctoral fellows are strongly encouraged to attend and present their work in poster format.