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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


University of California Santa Cruz: Assistant professor tenure track positions

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Description:

The University of California, Santa Cruz is doing a cluster hire for 4 assistant professors under the broad umbrella of Biomedical Sciences. One area of particular interest is Structural Biology, with emphasis on cryo-electron microscopy.  See https://recruit.ucsc.edu/JPF00756 for details and to apply.

UC Santa Cruz has a vibrant structural biology community and is in the process of installing a Glacios cryo-TEM.  We are also members of the BayArea Cryo-EM Consortium with UCSF, UC Berkeley, and UC Davis, and are within easy driving distance of the new NIH-funded Stanford-SLAC cryo-EM facility.


[Post Date: September 15, 2019]


Job opening to join the Structural Motility team at the Curie Institute Paris, France.

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Description:

We are looking for a post-doctoral fellow to join the team Structural Motility at the Curie Institute (Paris Center) directed by Anne Houdusse.

The Structural Motility team at the Institut Curie has gathered important structural insights on how force generated by molecular motors can power cellular processes in human health and disease. We combine chemical biology and cell biology approaches to test these insights and understand how molecular motors produce force, how their activity is regulated and how they are recruited to their cellular targets. Many of these motors are also involved in human pathologies and they are thus good targets for new therapies which we are helping to develop.

We are looking for an expert in biochemical, crystallogenesis and structural determination studies. The post-doctoral fellow will also gain expertise in functional and cellular studies.

A solid experience in crystallization and X-ray structural determination is required. Experience in the production and purification of recombinant proteins is a plus but we are ready to train a dynamic and motivated candidate.

If you are interested, please send a CV and a letter of motivation as well as letters of recommendation of your previous employers.

Contact : Anne Houdusse (anne.houdusse@curie.fr)

Recent publications

Robert-Paganin et al, Nat Commun. 10, 3286, 2019.

Robert-Paganin et al, Nat Commun. 9, 4019, 2018.

Planelles-Herrero VJ, Hartman JJ, Robert-Paganin J, Malik FI, Houdusse A. Mechanistic and Structural Basis for Activation of Cardiac Myosin Force Production by Omecamtiv Mecarbil. Nat. Commun. 8, 190, 2017.

Yu I-M*, Planelles-Herrero VJ*, Sourigues Y, Moussaoui D, Sirkia H, Kikuti C, Stroebel D, Titus MA, Houdusse A. Myosin 7 and its Adaptors Link Cadherins to Actin. Nat Commun. 8, 15864, 2017.

Houdusse A, Sweeney HL. How myosin generates force on actin filaments. Trends Biochem Sci. 41, 989-97, 2016.

Sweeney HL and Houdusse A, Myosin VI rewrites the rules for myosin motors, Cell, 141, 573-82, 2010.

Sweeney HL and Houdusse A. Structural and Functional Insights into the Myosin Motor Mechanism, Annu Rev Biophys. 39, 539-57, 2010.


[Post Date: September 10, 2019]


Job Opening for Institute Research Investigator

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Description:

This post is to bring your attention to a job opportunity for an Institute Research Investigator position at the University of Texas, MD Anderson Cancer Center (in Houston, Texas, USA). The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public.

We are seeking a highly motivated and collaborative individual to become a part of our team. As part of the Institute for Applied Cancer Science, the Research Investigator in Structural Chemistry will be responsible for producing proteins to enable X-ray crystallography and structure-based drug discovery, and support high-throughput screening efforts.

Salaries are competitive and commensurate with experience. For more information and to submit an application please navigate to the link above.


[Post Date: September 6, 2019]


Senior Research Computing Scientist

Description:

Position Title:  Senior Research Computing Scientist

The structural biology Advanced Research Computing (ARC) team at SBGrid/Harvard Medical School has a position opening for a Senior Research Computing Scientist. The ARC team designs, implements, and maintains a specialized computing infrastructure to support all phases of macromolecular structure determination via CryoEM, X-ray Crystallography, and NMR. The infrastructure includes storage to support data acquisition as well as Linux workstations and OSX research desktops for data processing. We also support computational clusters and specialized research instrumentation computers. The ARC team works in close collaboration with the SBGrid Consortium staff who curate and maintain a library of approximately 400 structural biology software titles.

Job description: As a member of the ARC team, the Senior Research Computing Scientist will provide computing support to structural biologists at Harvard University, Harvard Medical School, and affiliated institutions. The supported groups include the laboratories of Stephen Harrison, Tim Springer, Hao Wu, Mike Eck, Eric Fischer, Stephen Blacklow, Andrew Kruse, Suzanne Walker, James Chou, and Tom Rapoport. You will work as a member of a multidisciplinary research and computing team that integrates ARC, SBGrid Software Consortium, research laboratories, CryoEM Center, and teaching initiatives. Your daily responsibilities will include managing our HPC systems, administration of Linux and OSX workstations, and administration of various computing services (e.g. storage, authentication, cluster/grid job submission, backups). Additional responsibilities will include supporting determination of macromolecular structures with CryoEM, X-ray Crystallography and NMR techniques.

Basic qualification: PhD in Structural Biology; or equivalent combination of education plus relevant research experience. 5-7 years of structural biology research computing support.

Additional qualifications: Requires an understanding of python or other programming languages. A strong knowledge of Linux and OSX operating systems is essential.

The successful candidate will have excellent organizational skills and a particular ability to work independently and prioritize work in an environment of multiple and conflicting interests; proven project and/or program management skills; excellent interpersonal and communications skills; and an ability to work with discretion. For more information please contact apply@sbgrid.org.


[Post Date: September 6, 2019]


Description:

The Beck group is moving to Hamburg, where we will have labs well-equipped for chemistry, biochemistry and molecular biology. Moreover, state-of-the-art facilities for structural characterizations such as PETRA III are close by.

We are looking for a postdoctoral fellow, funded by the Boehringer Ingelheim Foundation, for a project involving protein redesign, protein production and functionalization, and application in imaging and therapy.

You should have a PhD degree in chemistry, biochemistry or biology and some experience with protein production and purification. Skills in structural biology / computational design are a plus. The post is available from January 01 2020.

Full details of the post and the applications process are available here:

https://www.uni-hamburg.de/uhh/stellenangebote/wissenschaftliches-personal/fakultaet-mathematik-informatik-und-naturwissenschaften/06-10-19-475-en.pdf

The group homepage can be found here:

https://www.chemie.uni-hamburg.de/institute/pc/arbeitsgruppen/beck.html

https://www.ac.rwth-aachen.de/extern/beck/

The deadline for applications is Oct 06 2019.


[Post Date: September 6, 2019]


Postdoctoral Researcher, Membrane Structural and Functional Biology, Caffrey Lab, Trinity College Dublin, Ireland

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Description:

Post Summary The Membrane Structural and Functional Biology group seeks to solve the structure of medically important membrane proteins for use in structure/function studies and for structure-based therapeutics development. Target proteins are involved in communicable and non-communicable diseases.

An exciting postdoctoral research position is available in the Group. We are looking for a highly motivated, creative and hardworking individual with experience in biochemistry and molecular biology to join our multidisciplinary team at Trinity in a lab that offers superb facilities. Individuals interested in moving into the membrane protein field are encouraged to apply.

Person Specification The candidate must have a Ph.D. in biochemistry, biophysics, molecular biology or a related field. Demonstrated success in all aspects of molecular biology, recombinant protein production, purification, and functional characterization is required. Experience with membrane protein over-expression, crystallization, and structure-function studies is desirable. The candidate should be a highly motivated and creative individual who enjoys working as part of a collaborative, multidisciplinary team. Strong leadership, communication and teaching skills are decided assets.

Salary €37,874 - €43,782 per annum depending on experience

Closing Date Until the position is filled

Principal Investigator Prof. Martin Caffrey https://www.tcd.ie/Biochemistry/research/caffrey/

Application Procedure Candidates are asked to submit a letter detailing education, training and laboratory experience. In the letter, the candidate should outline why they feel they are suitable for the position in an interdisciplinary group that will involve extensive interaction with collaborators and data collection at facilities around the globe. The letter of application must be accompanied by a full CV to include the names and contact details of two referees (email addresses and phone numbers to be provided). At least one referee should be an individual the candidate has worked with and who has agreed to provide a letter of reference on the candidate’s behalf.

Applications should be emailed to: MSFBlab2019@gmail.com


[Post Date: September 3, 2019]


Postdoctoral Program in Integrated Structural Biology at Umeå University

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Description:

Two postdoctoral fellowships are open for the 2019 call at the Integrated Structural Biology (ISB) environment at Umeå University.  Umeå University offers a vibrant and international atmosphere for structural biology research. There are 19 research groups and close to 100 persons affiliated with ISB. The ISB environment has regular seminars and candidates will be broadly exposed to different structural biology techniques. The university has state of the art infrastructure for cryoEM, NMR spectroscopy, supercomputing and x-ray crystallography (please visit www.biostruct.umu.se for details on equipment).

The openings will be filled using a procedure adapted from EMBL and the two top candidates that has applied to one of the six available projects will be selected. The projects are interdisciplinary and will ensure that the candidate will receive competitive training.

The program is open to all nationalities with relevant doctoral level education and work experiences and the openings will include the following to be considered by potential candidates: 

  • Two years funding (incl. running costs) for research within a multidisciplinary structural biology environment 
  • Access to ISB affiliated core facilities and technical platforms 
  • Integration with postdocs at ISB and also MIMS (Molecular Infection Medicine Sweden)  for carrier development and joint activities

Instructions

Candidates should (in addition to submitting their CV, publications, certificates, etc.) write a “MOTIVATION LETTER” (1-2 pages) specifying: i) why you are interested in performing postdoc research studies within ISB and ii) why in particular you wish to do this with the PI:s and project idea selected from our list The applicants must also write a one-page research plan for the project. We encourage the applicants to contact the PIs for discussion of the project before submission. Please email your application to ISB@umu.se no later than October 15. For inquires please contact the indicated lead-PI or co-PI’s from the list of projects. Further info about the ISB Postdoctoral program can be found here: https://www.biostruct.umu.se/isb-postdoctoral-program/

PROJECTS

Below please find a list of the available projects together with contact information to PI’s.

Mechanistic origin of ATP-dependent ion transport

Computational methods can be used to reveal connections between subtle trigger events and large-scale conformational changes in proteins. In this project, computer simulations and time-resolved X-ray solution scattering experiments (TR-WAXS) will be used to identify such connections in ATP-dependent membrane protein transport. Specifically, classical MD and QM/MM simulations will characterize effects of phosphorylation, protonation/deprotonation, and ion binding in P-type ATPase ion transport. Existing high-resolution protein structures as well as low-resolution models of transient states in solution (obtained from time-resolved X-ray scattering experiments) will serve as the basis for the simulations. The project aims to determine structural dynamics and corresponding free energy levels to provide a structural/thermodynamic basis for understanding ATP-driven ion transport across biological membranes. The project will be lead by Dr. Andersson (classical MD/X-ray scattering) and Dr. Nam (QM/MM). Part of the project will take place at University of Texas, Arlington, USA.

Lead PI: Magnus Andersson: magnus.p.andersson@umu.se

Co-PI:   Kwangho Nam: kwangho.nam@umu.se

Mechanistic study of the autophagic protein ATG8/LC3 in membrane morphogenesis

Autophagy is a highly conserved and sophisticated “self-eating” process in eukaryotes and plays a key role in human health and disease. Formation of double-membrane autophagosomes is the key process in autophagy and the LC3 protein family is required for autophagosomal membrane expansion and closure. However, the molecular mechanisms of these processes remain unclear. In this project we will focus on the membrane interactions of the LC3-PE protein. Wu’s lab have prepared LC3-PE by semisynthetic approaches and showed that LC3-PE promotes membrane fusion in vitro . The protein will here be studied using structural biology tools, primarily NMR spectrosocpy, together with Mäler’s group. The proposed project provides an excellent opportunity for combining Wu’s expertise concerning protein chemistry with biophysical and structural biology (NMR) studies of the interaction between one key component in autophagy and lipids in Mäler’s group.

Lead PI: Lena Mäler: lena.maler@umu.se  

Co-PI:  Yaowen Wu:  yaowen.wu@umu.se

Functional and structural analyses of the dynamic conformational changes of Opsins upon photo responsiveness

Opsins, including Opn3 and Opn5, are G-coupled receptors that detect light by transforming the energy of a photon into a cellular response. The specific roles of Opn3 and Opn5 are unresolved, and their wide expression patterns in the brain and other organs make them attractive for structure/function studies. By using biophysical techniques coupled to structural and molecular biology, this project aims to examine the structure and conformational changes of Opn3 and Opn5 upon light activation. The suitable postdoc candidate will purify protein complexes that will be studied with Cryo-EM, and time-resolved wide angle x.-ray scattering (TR-WAXS). Three PI:s with complementary set of expertise are connected to this project: Linda Sandblad has extended knowledge of Cryo-EM to study protein structure and membrane proteins in cellular environments. Magnus Andersson has previous experience with analyzing conformational changes in light sensitive membrane proteins using TR-WAXS. Lena Gunhaga has an expertise in sensory neural development using a range of molecular biology methods.

Lead PI: Linda Sandblad: linda.sandblad@umu.se

Co-PI:  Magnus Andersson: magnus.p.andersson@umu.se

Co-PI:   Lena Gunhaga: lena.gunhaga@umu.se

The structural basis of promiscuity in toxin-antitoxin networks

Bacterial toxin-antitoxin (TA) systems have diverse functions, including defence against phages and maintenance of genetic elements. The lab of Gemma C. Atkinson has discovered a large network of promiscuous toxin-antitoxin domain pairs that swap partners across vast evolutionary distances. These novel TAs are being characterised microbiologically and biochemically in collaboration with the lab of Vasili Hauryliuk. This post-doctoral project aims to discover the structural and molecular evolutionary basis of toxicity, neutralisation by antitoxins, and partner swapping. TA complexes will be analysed structurally by X-ray crystallography in the lab of Karina Persson (lead PI), and the dynamics of complex formation will be investigated with NMR, working with the lab of Gerhard Gröbner. The successful post-doc will receive training in these two structural biology methods, as well as the interpretation of structures in the light of evolution and molecular function.

Lead PI: Karina Persson: karina.persson@umu.se

Co-PI:  Gerhard Gröbner: gerhard.grobner@umu.se

Co-PI:  Gemma C. Atkinson: gemma.atkinson@umu.se

Understanding assembly and function of the bacterial cell wall

Bacteria are protected from environmental insults by a peptidoglycan (PG) cell wall. Hence, the enzymes involved in the production and turnover of PG are preferred targets for many of our most successful antibiotics. Our team has discovered a novel PG synthetic protein in Vibrio cholerae (i.e. PBP1V), the causative agent of Cholera. PBP1V is conserved in a number of Gram negative pathogens and appears to support cell wall integrity under challenging conditions. Understanding the nature and function of PBP1V will help to address fascinating questions regarding peptidoglycan homeostasis and plasticity and might provide a new target against bacterial infections. The recruited postdoc will work on the structural and biochemical characterization of PBP1V. The team composed by Elisabeth Sauer-Eriksson, Felipe Cava and Magnus Andersson will provide a stimulating environment and the right interdisciplinary cross training for the postdoc. 

Lead PI: Elisabeth Sauer-Eriksson:  elisabeth.sauer-eriksson@umu.se

Co-PI:   Felipe Cava: felipe.cava@umu.se

Co-PI:   Magnus Andersson:  magnus.p.andersson@umu.se

A molecular basis of factors involved in honeybee hive collapse

During the last decade, studies have identified factors that cause a dramatic decline in honeybee hives. Habitat loss, intensified agriculture, pollution and climate change weakens wild and managed honey bee cultures causing their disappearance. Similarly, an alarming prediction suggests the extinction of more than 40 % of the world’s insect species in the next decades with implications for the pollination of many essential plants.This interdisciplinary project involves the analysis of affected environmental samples using microscopy, microbiology and molecular biology to confirm existing and identify novel elements involved in honeybee hive collapse. This will be followed by a targeted biochemical and structural characterization of critical molecular factors using cryo-EM and X-ray crystallography. The candidate will have the opportunity to participate in research that explores a significant environmental problem with a multi-angle approach to relate observations made in nature with the underlying atomic basis.

Lead PI: Jonas Barandun: jonas.barandun@umu.se

Co-PI:  Uwe. H. Sauer:  uwe.sauer@umu.se

Co-PI:   Natuschka Lee: natuschka.lee@umu.se


[Post Date: September 3, 2019]


Beamline Scientist at AMX, NSLS-II, BNL, NY, USA

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Description:

A position of beamline scientist for the highly Automated Macromolecular Crystallography beamline (AMX) at the National Synchrotron Light Source II is currently open.

The National Synchrotron Light Source-II (NSLS-II) at Brookhaven National Laboratory (Upton, NY, USA) seeks a scientist to join the Structural Biology program that operates two state-of-the-art macromo­lecular crystallography (MX) beamlines, one life-sciences scattering beamline, and a cryo-EM facility. The successful candidate will be keen to make best scientific use of the MX beamlines with their micro-focus beams and high degree of automation. Our early experience with these cutting-edge MX beamlines shows that they have ability to produce usable data rapidly from crystals that gave poor diffraction elsewhere.

The principal work in the next years will be to support all aspects of the beamline operations and to continue developing these instruments to expand opportunities for structural biology research.

Position Description

The new scientist who joins this multi-national group operating cutting-edge instruments will bring innovation and teamwork to further the quality of X-ray crystallography beamlines. The successful candidate will be encouraged to develop opportunities for scientific collaborations that exploit the unique qualities of our beamlines. We would emphasize extending the mission and technical scope of the beamline, especially by further increasing the level of automation including sample centering for complex data collection and data processing in our high-performance computing environment. Responsibilities will also include interacting with the scientific user community to augment their scientific productivity with complementary NSLS-II life-science user programs and our cryo-EM facility.

  Our group operates 2 state of the art MX beamlines, AMX (high throughout and automation) FMX (frontier experiments including serial crystallography) and LIX the life science scattering beamline. AMX is a microfocus beamline with a beam size of 7x5 um2 and a flux of 4.5 1012 ph.s-1. AMX is a tunable beamline with a 5-18 keV range, well suited for high resolution data collection from large assemblies and native phasing from challenging samples.  AMX is equipped with a state-of-the-art robotics system, a high capacity sample Dewar holding up to 384 samples and an Eiger 9M detector.   Further details and how to apply can be found at the link above.


[Post Date: August 30, 2019]


Post-doctoral research position in membrane protein structural biology

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Description:

A post-doctoral research position is high-resolution structural biology of membrane protein complexes is available in my laboratory at the Institute for Bioscience and Biotechnology Research (IBBR;https://www.ibbr.umd.edu/profiles/s-saif-hasan) in Rockville MD. The post-doctoral researcher will have a choice of multiple structure-focused projects in cancer biology and viral pathogenesis using single particle cryoEM and crystallography. The researcher will have independence to guide the direction of their research and to pursue novel ideas should (s)he find an interesting scientific question related to the general research focus of my laboratory.

IBBR is run jointly by the University of Maryland and the National Institute of Standards and Technology (NIST). We are home to a large community of structural biologists and have extensive interactions with national laboratories and private companies located in the DC-Maryland area. Our new cryoEM facility houses a 200 keV Thermo Fisher Talos Arctica microscope equipped with a Falcon 3 direct electron detector. Our facilities will soon be expanded to include a new 200 keV Thermo Fisher Glacios microscope, a Gatan K3 direct electron detector and a Volta phase plate. My lab works in close collaboration with research groups in IBBR that specialize in mass-spectrometry, computational biology, NMR spectroscopy, and small angle X-ray scattering.

Applicants should have experience in insect or mammalian cell culture for protein production. Experience in handling membrane proteins will be helpful. Prior training in single particle cryoEM and/or crystallography is desirable but not essential. If you are a membrane protein biochemist, especially with experience in G-proteins, and you want to explore questions in structural biology, this is the position for you.

Applicants who have received their PhD or MD/PhD degree should email me (sshasan@som.umaryland.edu) a single PDF file containing a short cover letter (no more than one page), a detailed curriculum vitae, contact information for three references, and upto 3 reprints of representative first authorship publication(s).

The University of Maryland, Baltimore is an Equal Opportunity, Affirmative Action employer. Minorities, women, individuals with disabilities and protected veterans are encouraged to apply.


[Post Date: August 30, 2019]


Scientist, Structural Biology & Crystallography

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Description:

We are seeking a highly motivated Scientist to join the Structural Biology group to structurally characterize novel compounds that target undruggable proteins. The candidate should be a team player with a broad knowledge of protein biochemistry and deep experience in X-Ray crystallography, a passion for scientific research as applied to drug discovery and development, and be eager to work in a fast-paced multidisciplinary environment.

To learn more or apply please follow the link above.


[Post Date: August 30, 2019]


Senior Director or Executive Director Structural Biology and Biophysics

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Description:

Viva biotech is a leading CRO organization supported by Angel investors and a US leading PE fund since 2008, located in Shanghai. China. Viva provides structure-based drug discovery, biologics and medicinal chemistry services to global pharmaceutical and biotech companies for their pre-clinical stage innovative drug development. Viva biotech is in a rapid expansion mode since its successful IPO on the Hong Kong Stock Exchange on May 9th, 2019. We have openings for senior director and executive director in structural biology and biochemistry. Anyone who is interested in the position, please send CV to hr@vivabiotech.com

Job Description:

We are seeking a highly motivated and innovative individual with strong working experiences in structure biology, biochemistry, as well as project management experience. The position will require leading multiple projects, working closely together with project managers and our partners to accomplish client goals successfully and timely. The candidate will be deeply involved in daily communications with clients and teammates via TC, emails and project meetings. The successful candidate is also required to build sustainable strong relationships with clients and external partners by active communications, professional conferences and on-site visits.

Key Responsibility:

The successful applicant will be responsible for the execution of the following tasks:

  • Provide leadership and expertise in structural biology, protein biochemistry, and biophysics.
  • Support and assist project managers in multiple projects of recombinant protein production, protein characterization and complex structure determination for activity-assay and structural studies.
  • Provide scientifically sound guidance, resolve and promptly response to any issues, problems or challenges which may arise.
  • Demonstrate strong customer and service focus. Able to thrive and deliver results in a fast paced, dynamic and highly multi-tasking environment.
  • Enable a positive team environment and interact with multi-disciplines project teams.
  • Lead a team of Cyro-EM including recruiting, on-boarding, coaching, business development, and performance management.
  • Understand and comply with company regulations, policies and SOPs, contribute to continuous improvement.
  • Candidate may periodically be asked to travel to different places in the US or Europe for business purpose and face-to-face meetings with clients.

Required Qualifications:

  • Doctoral degree or equivalent in structural biology, biochemistry, biophysics or a related field with 10+ years of industry experience
  • A proven track record of scientific achievement illustrated in your list of publications
  • Broad knowledge in protein production, characterization, macro molecular crystallography, structural biology and biophysics
  • Years of working experience in managing projects from different targets with clear understanding of project needs and ensuring delivery of high-quality data with clear communication of timeline.
  • Demonstrated ability to be flexible and adaptable to changing business needs and client requirements.
  • Excellent written, verbal in both English and Chinese as well as interpersonal communication skills is a must.
  • Strong working knowledge or familiarity with biophysical methods techniques such as NMR, ITC, TSA, SPR, MST, etc would be a plus.
  • Broad experience or familiarity with different aspects of structure determination by Cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and 3-D reconstruction would be an additional advantage.


[Post Date: August 30, 2019]


Postdoc GPCR Biology at IIT Kanpur, India

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Description:

We have post-doctoral positions available in our laboratory to work on cutting edge projects related to GPCR biology (structural studies using X-ray and cryo-EM, discovering new signaling pathways, and generating synthetic tools to modulate receptor signaling).

We are looking for candidates with relevant prior experience (protein biochemistry, cell signaling, X-ray crystallography and cry-EM).

Please refer to Cell Reports, 2019; Nature Structural & Molecular Biology,

2018 Jun;25(6):538-545; Nature Nanotechnology. 2017 Dec;12(12):1190-1198; Nature Communications, 2016 Nov 9;7:13416; Cell, 2016 Aug 11;166(4):907-19; Nat Rev Mol Cell Biol, 2015 Feb;16(2):69-81; Cell, 2014 Dec 18;159(7):1712; Trends Biochem Sci, 2014 Dec;39(12):594-602; Nature, 2014 Aug 14;512(7513):218-22; Nature, 2013 May 2;497(7447):137-41 for a general overview of the research direction and experimental approaches.

Interested applicants are requested to send their CV and the name of three referees to arshukla@iitk.ac.in.


[Post Date: August 28, 2019]


LabGenius Protein Scientist Job Opening

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Description:

LabGenius is currently hiring. At LabGenius, we’re building a platform to discover revolutionary biological medicines coupling wet-lab techniques with machine learning and automation. We have exciting growth plans for the next 18 months and are looking for a focused Protein Scientist to join us on our mission!

In my team we clone, express (in E.coli/mammalian cells), purify and characterise (by biochemical/cell assays and biophysics techniques such as MST/SPR) proteins that come from the machine learning pipeline, both in a high throughput (96 1ml cultures) and large scale preps using AKTA chromatography systems.

We are looking for more junior candidates who want to learn new things, ideally a graduate with a couple years experience (i.e. someone who has done a long BSc/MSc lab project where they became independent in the lab, or an industrial placement) or someone immediately post-PhD. There are plenty of learning opportunities here as we are a very multidisciplinary team with robot engineers, library design scientists, computer scientists and business development all working together closely. For more information please visit the link above.


[Post Date: August 28, 2019]


Postdoctoral Fellow position at UT Health San Antonio, San Antonio, Texas

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Description:

The laboratory of Dr. Yogesh Gupta (http://ccri.uthscsa.edu/YGupta.html) at University of Texas Health Science Center in San Antonio (UT Health San Antonio™) is seeking a  motivated scientist with strong interest in structural/mechanistic studies on protein-nucleic acid assemblies in pediatric cancers. We combine structural/biophyiscal (X-ray, NMR, cryo-EM, AUC, SAXS), and cell-based methods to address basic mechanistic questions, and exploit this knowledge for drug discovery.

Our lab is physically located within the Greehey Children’s Cancer Research Institute (Greehey CCRI) at UT Health San Antonio.  We have full access to an extensive array of core institutional facilities (Biochemistry core, CIDD, Research core labs) located within the Department of Biochemistry and Structural Biology, the Joe R. and Teresa Lozano Long School of Medicine, and Greehey CCRI.  Applicants with demonstrated experience in protein biochemistry, enzyme kinetics, and structural biology are preferred. Candidates are expected to possess strong organizational, interpersonal skills, and ability to work as part of a team. Candidate should hold (or soon expect to hold) a PhD or equivalent degree in a related discipline. An ideal candidate should not have >2 years of prior postdoc experience. Prior experience in X-ray crystallography is desirable but not required.

Salary is competitive. San Antonio offers affordable cost of living and there is no state income tax in Texas.

Please visit the websites below to learn more about our work and future directions –

http://ccri.uthscsa.edu/YGupta.html

If interested in applying, please send a short description of your research accomplishments, current CV with a list of three (3) references to Dr. Yogesh Gupta (email: guptay@uthscsa.edu).

The Greehey Children’s Cancer Research Institute is a unique specialized cancer research center focusing on basic and translational research in childhood cancer and occupies a state-of-the-art 100,000 sq. foot research facility on the university’s Greehey Academic and Research Campus.

San Antonio is the nation’s seventh largest city and is located at the edge of the beautiful Texas Hill County. San Antonio offers a rich, multi-cultural community, affordable cost of living, excellent weather and a thriving biomedical industry.

All Postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Opportunity/Affirmative Action Employer including protected veterans and persons with disabilities.


[Post Date: August 26, 2019]


Postdoc opportunity (Cambridge, UK)

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Description:

There is an exciting opportunity for a postdoc to join my group to study how cells sense and silence viral RNA and DNA using a combination of structural approaches (X-ray crystallography or cryoEM), biochemical assays, proteomics and cell-based signaling assays. We benefit from an outstanding research environment as part of the University of Cambridge Department of Medicine’s Molecular Immunity Unit, which is embedded within the MRC Laboratory of Molecular Biology (MRC-LMB).  Please spread the word, or apply at the link above.

 


[Post Date: August 24, 2019]


Postdoctoral Positions in Structural RNA Biology at the NIH

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Description:

The Messenger RNA Regulation and Decay Section, RNA Biology Laboratory (RBL), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), is seeking postdoctoral candidates with training/expertise in RNA/protein structural biology/biochemistry. Research experience in RNA biology or structural/biophysical techniques will be considered advantageous. Strong work ethic, excellent communication skills and ability to work in a multidisciplinary team are essential.

The focus of our research is to understand the mechanisms by which the function of messenger RNA is regulated. We are especially interested in exploring in molecular detail the processes of deadenylation and decapping as well as the connections in the metazoan 5´-to-3´ cytoplasmic degradation pathway. Recently, we have described the biochemical reconstitution of human CCR4-NOT deadenylation complex and uncovered new links between decay factors. The next stage will be to take structural approaches, especially high-resolution cryoEM, in combination with other biophysical techniques toward the study of the human mRNA decay machinery. Significant preliminary data has already been generated for several projects and candidates will join an established research program.

For high-resolution cryoEM, a Talos Arctica equipped with a K3 detector together with a Vitrobot plunger is available on site together with a Talos L120C for screening. Titan Krios microscopes are also locally accessible at dedicated facilities on the NIH campuses in Frederick and Bethesda. For crystallography, there is regular access to synchrotron beamlines at the Argonne National Laboratory. Automated crystallization platforms and automated imagers for crystal detection are available in the neighboring Structural Biophysics Laboratory. In addition, a biophysics core facility contains an array of instruments for biophysical characterization. High-performance computational resources including a GPU-enabled cluster are also provided. Further information about the core facilities can be found here: https://ostr.ccr.cancer.gov/resources/core.

For relevant recent publications please see: Raisch et al. (2019) Nature Communications, Chang et al. (2019) Nucleic Acids Research, Valkov et al. (2016) Nature Structural & Molecular Biology.

We are looking for enthusiastic, imaginative and dedicated scientists to join our research team working on exciting RNA structural biology projects. The NIH intramural program provides ample opportunities for advanced training to early-career scientists to develop valuable research and transferable skills. A vibrant and collegiate NIH community with diverse expertise in RNA, chemical and structural biology ensures a unique research environment with excellent collaborative opportunities. NIH offers a competitive salary and comprehensive health insurance as well as a host of other benefits. Candidates must have a doctoral degree or expect to receive their degree shortly. Appointments will be for one year initially and renewable for up to a maximum of 5 years.  The NIH is dedicated to building a diverse community in its training and employment programs.  This position is subject to a background investigation.

Applicants should send their CV and contact details for three references to Dr. Eugene Valkov: eugene.valkov@nih.gov. Informal inquiries are welcome. More information can be found at https://ccr.cancer.gov/RNA-Biology-Laboratory/eugene-valkov. The RNA Biology Laboratory is located on the Frederick campus of the National Cancer Institute in Maryland, U.S.A.

DHHS, NIH, and NCI are Equal Opportunity Employers


[Post Date: August 22, 2019]


Biochemistry & Biophysics Faculty at The University of Chicago

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Description:

The Department of Biochemistry and Molecular Biology invites applications for a tenure-track position at the assistant professor level, although outstanding candidates at a higher rank will be considered. We seek scientists studying macromolecular dynamics and structure, mechanisms of molecular function and related frontier areas. Appropriate topics include proteins, nucleic acids and their assemblies; membrane proteins; cellular processes in prokaryotes and eukaryotes (for example, proteostasis, condensates and immunology);
biomolecular design; chemical biology, and computational analysis. Our resources include cryoEM capability (Krios with tomography) and affiliations with Argonne National Laboratory and the Marine Biological Laboratory.

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[Post Date: August 22, 2019]


Postdoc positions in Luca Lab at Moffitt Cancer Center

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Description:

Our laboratory (www.thelucalab.org) is recruiting postdoctoral researchers interested in (1) studying the structural mechanisms of Notch receptor activation and (2) designing biologics to control Notch activity on specific tissue types. We use a multidisciplinary approach that integrates structural and cellular biology with cutting edge protein engineering techniques, such as directed evolution, to understand signaling mechanisms at the molecular level. These projects incorporate both basic and translational research, and Notch-targeted biologics will be evaluated as potential therapies for autoimmunity, developmental disorders, and cancer. Candidates will work with a team of immunologists, tumor biologists, and clinicians at Moffitt Cancer Center (Tampa, FL) to conduct research in a highly collaborative environment. The positions are funded for up to 5 years by an R35 MIRA grant from the NIH/NIGMS.

Ideal candidates have demonstrated expertise in protein biochemistry and molecular biology. Expertise in x-ray crystallography and protein or antibody engineering is preferred.

Position highlights
- Structure-function studies of Notch receptor signaling mechanisms
- Design biologics using protein engineering and directed evolution
- Collaboratively assess the therapeutic potential of biologics in disease models

Responsibilities
- Protein purification, biophysical characterization of protein-protein interactions, directed evolution, x-ray crystal structure determination, cellular signaling assays
- Mentor graduate students and technicians
- Compose manuscripts and postdoctoral fellowships, assist with grant applications
 
Credentials and qualifications
- PhD in Structural Biology, Molecular Biology, Biophysics, or a related field (required)
- PhD awarded within the past year (preferred)

How to apply
Candidates should e-mail the following to vince.luca@moffitt.org:
1) A cover letter that describes their motivation to pursue this position and summarizes past research accomplishments.
2) A current CV with recent publications and contact information for three references.

Moffitt Cancer Center Overview
Moffitt Cancer and Research Institute is a rapidly expanding, NCI-designated comprehensive cancer center that includes state of the art core facilities to support basic research. The Moffitt Chemical Biology Core is equipped with a Rigaku X-ray diffraction system and labs have regular access to the Advanced Photon Source Synchrotron (SER-CAT beamlines) for remote data collection. The Core also includes a Biacore T200, Nanotemper MST, Microcal ITC for analyzing protein-protein interactions and Mosquito crystallization robot for automated screening. Moffitt Cancer Center is located within the coastal community of Tampa Bay and is adjacent to the University of South Florida School of Medicine.


[Post Date: August 21, 2019]


Postdoctoral scientist position at Columbia University

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Description:

Crystallography, single-particle cryo-EM, and cryo-EM tomography neuronal surface proteins.

Our research program, in the new Mind Brain Behavior Institute at Columbia, is focused on proteins that mediate cell-cell recognition and their function in building the neural networks of the brain. Our lab is part of the vibrant NYC structural biology community, with regular access to beamlines at APS/Argonne and NSLS2/Brookhaven, and numerous Titan Krios microscopes at Columbia and the nearby New York Structural Biology Center.

Relevant publications include:

Brasch et al, Nature Nature (2019) 569, 280-283.

Cosmanescu et al, Neuron (2018) 100, 1385-1400.

Dionne et al, Neuron (2018) 99, 480-492.

Candidates should have a PhD in Structural Biology/Biophysics or related disciplines, and a track record of research achievements. Knowledge of protein purification and experience in structural biology are essential.

Funds for this post are available for 3 years in the

Informal inquiries may be made to Dr Lawrence Shapiro (LSS8@columbia.edu).


[Post Date: August 20, 2019]


Multiple Postdoctoral Fellowships available at the “Multiscale Research Institute for Complex Systems” at Fudan University of Shanghai

Description:

The Multiscale Research Institute for Complex Systems (MRICS) at Fudan University is located at the Zhangjiang Campus of Fudan University and is supported by the Shanghai High-level Talents Program. MRICS is strongly committed to the development of novel and effective multi-scale imaging technology that spans microscopic molecular structures all the way to macroscopic medical imaging, with the aim to provide unprecedented spatial and temporal insights into the structures and functions of living beings at all levels (molecules, cells, tissues, organs and even whole organisms). Specifically for structural biology, MRICS is equipped with a state-of-the-art cryo-EM facility that includes FEI Titan Krios equipped with Volta phase plate, Glacios, Talos and Aquilos. MRICS is also located next to Shanghai Synchrotron Radiation Facility for X-ray crystallography.

Our team includes Nobel laureate and international leading interdisciplinary experts.    

We have new openings for multiple postdoctoral fellows in structural biology who will be mainly involved in structural studies of important biological systems by means of X-ray crystallography and cryo-electron microscopy including single-particle and tomography. 

Requirements: 

The applicants should have a recent Ph.D. degree (within three years of graduation) or will have a Ph.D. degree within the next six months in biology or chemistry-related fields, are devoted to excellence in scientific research, have strong sense of responsibility, and are highly motivated and hardworking.  For these positions, extensive experience in protein expression and purification is a must, while prior experience in X-ray crystallography or cryo-EM is a plus, but is not required.  

Compensation:

1) We offer internationally competitive salary and fringe benefits, the level of salary will be determined according to the applicant's experience and qualification; 

2) We will assist in applying for low-rent housing in Shanghai and provide certain housing subsidies; 

3) We have ample opportunities to collaborate with renown laboratories worldwide;

4) We provide support for applying for funding opportunities whenever applicable.  

Shanghai is one of the most cosmopolitan cities in China with strong economy and vibrant scientific community. 

For interested applicants, please submit postdoctoral application packages (a combined pdf) including resumes, concise research interest statements, representative publications, phone numbers and email addresses of three academic referees to: mrics_fd@fudan.edu.cn

We look forward to your joining of our first-class team!


[Post Date: August 20, 2019]


PostDoc Research Associates at UK Dementia Research Institute at King's College, London

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Description:

Department: Basic & Clinical Neuroscience

We are seeking to appoint two research associates willing to carry out an interesting and challenging project of Structural Biology in UK Dementia Research Institute (UK DRI) at King's College. The UK DRI is embedded within the Department of Basic and Clinical Neuroscience.

Funded by the Medical Research Council, Alzheimer's Society and Alzheimer's Research UK, the UK DRI is a national consortium focused on cutting-edge dementia research. The post-holders will be involved in developing a project in Structural Biology of neurodegeneration research as part of a wider network of centres. The roles will involve an integrated biological approach based on molecular biology, protein biochemistry, enzymology, spectroscopic, synthetic biology, crystallography and/or NMR and/or cryo-EM methodologies with the aim of understanding the role of specific target proteins in neurodegeneration and dementia.

These posts will be offered on a fixed-term contract for 3 years.

These are full-time posts - 100% full time equivalent.

The selection process will include a panel interview and a presentation.

Grade and Salary: Grade 6, £37,689 - £44,292 per annum, inclusive of

£3,500 London Weighting Allowance

Closing Date :     17-Sep-2019

For further details (Job pack, Job application) please visit the link above.


[Post Date: August 19, 2019]


Post-doctoral Fellowship at the University of Texas

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Description:

An NIH-funded Post-doctoral fellowship position is available at the University of Texas (UTMB) located in the greater Houston area in the research team of Dr. Gabrielle Rudenko. We study the protein interaction network at synapses (the contact and communication point between neurons in neural circuits), and processes that control synapse development. Many of our proteins of interest serve as potential novel therapeutic targets for neurological disorders. The ideal candidate will be an enthusiastic and dynamic structural biologist with experience in biochemistry, crystallography and/or cryoEM who is interested in combining the fields of structural biology and neuroscience.

Our laboratory is part of the endowed Sealy Center for Structural Biology and Molecular Biophysics (SCSB). The SCSB provides access to exceptional X-ray, NMR, Biophysics, and Electron Microscopy facilities. Ample access to synchrotron beam-time is coordinated through the SCSB. In addition, a Titan Krios Cryo-TEM equipped with a state-of-the-art direct electron detector has just been installed at UTMB. See http://scsb.utmb.edu/resources/ Extensive career develop training is also available including courses in scientific writing, comprehensive grant writing and leadership skills.

Recent work and general research interests from our group include:

DOI:10.1016/j.sbi.2019.05.020 (Curr. Opin. Struct. Biol. 2019)

DOI: 10.1016/j.jmb.2018.08.026 (J Mol. Biol. 2018)

DOI: 10.1016/j.neuron.2017.06.009 (Neuron 2017)

DOI: 10.1093/nar/gkx795 (Nucl. Acids Res. 2017)

Qualifications: Experience in protein crystallography, molecular biology, bacterial/insect cell culture, protein purification, crystallization and biophysical techniques. Good written and oral communication skills in English. Ability and desire to work as part of a highly motivated and collaborative team.

UTMB is part of the Texas Medical Center, the world’s largest medical center located in greater Houston. UTMB has a research campus situated on Galveston Island offering a pleasant subtropical climate that is within commuting distance of Houston, the fourth largest city in the United States and a leader in the arts, education, and health care.                                                                             
To apply, please e-mail the following to garudenk@utmb.edu CV, contact information for three references (address, phone and e-mail), a list of your experimental expertise and skills relevant to this position. Visa sponsorship is available for non-US nationals. You must have received you PhD degree to be eligible. For more information please visit http://scsb.utmb.edu/labgroups/rudenko/

The University of Texas is a non-discriminatory, affirmative action employer.

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[Post Date: August 15, 2019]


Postdoc Protein Biochemistry and Crystallography

Description:

We are looking for a highly motivated Postdoctoral researcher for our protein biochemistry and crystallography laboratory at the Dept. of Biochemistry at University Bayreuth, Germany. We use protein crystallography and a variety of biochemical and biophysical methods for the structural and mechanistic characterization of cellular signalling systems with relevance to aging mechanisms and aging-related diseases. We then aim to develop small molecule modulators that exploit the identified signalling mechanisms. The postdoc project will either focus on soluble adenylyl cyclase or deacylases of the Sirtuin family, for exemplary publications see Nat Chem Biol. 12, 838-44; PNAS 111, 3727-32; Nat Commun. 8:1513; Angew Chem Int Ed Engl. 56, 1007-1011.

Our laboratory is located in a new building at the University of Bayreuth, Germany and equipped with state-of-the-art facilities for protein biochemistry, x-ray crystallography, and mass spectrometry. We offer excellent research opportunities and a stimulating environment for research in structural biology. The position is open immediately, salary base is TV-L E13.

The ideal candidate is a highly motivated, independent PhD with strong background in structural biology and protein biochemistry. Additional experience in molecular biology would be an asset.

Applications from severely disabled individuals with equal qualification and aptitude will be given preference. The University of Bayreuth is an equal opportunity employer and we therefore especially encourage women to apply.

Applications (including CV, research experience, and two names and contact information for references) should be sent as PDF or by mail to

Prof. Dr. Clemens Steegborn

University of Bayreuth

Dept. Biochemistry, NW III
Universitaetsstr. 30
95447 Bayreuth, Germany

email:  sekretariat.biochemie@uni-bayreuth.de


[Post Date: August 15, 2019]


Research Scientist Engineer 1 Institute for Protein Design

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Description:

RESEARCH SCIENTIST ENGINEER 1

Req #:

170450

Department:

BIOCHEMISTRY - INSTITUTE FOR PROTEIN DESIGN

Posting Date:

07/31/2019 

Closing Info:

Open Until Filled 

Salary:

Salary is commensurate with education and experience 

Shift:

First Shift 

Notes:

As a UW employee, you will enjoy generous benefits and work/life programs. For a complete description of our benefits for this position, please visit our website, click here.  

As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem solving skills and dedication to build stronger minds and a healthier world.

UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty. All of which has allowed the UW to be nationally recognized as a “Great College to Work For” for four consecutive years.

About the Institute for Protein Design:
The Institute for Protein Design (IPD) at the University of Washington in Seattle is creating a new world of synthetic proteins to address 21st-century challenges in medicine, energy, and technology. The IPD is a unique interdisciplinary environment where world-class researchers with expertise in computing and software, biochemistry, genome sciences, biological structure, pharmacology, immunology and other basic science disciplines, as well as clinical medicine, work together to both computationally design and experimentally characterize novel biomolecules. Current projects include the design of novel therapeutics for cancer, neurological diseases, and more, as well as new vaccines, nanomaterials, and enzymes.

The UW Institute for Protein Design is seeking to hire a RESEARCH SCIENTIST ENGINEER 1 whose duties will be to provide experimental support for research projects as part of the Translational Science Program.  The Research Scientist/Engineer will be part of a small team focused on the biophysical characterization of proteins for both internal investigators as well as external collaborators

Main duties will include maintenance of X-ray systems, X-ray diffraction data collection in conventional systems in laboratory and using synchrotron facilities. Additional tasks will include support high-resolution microscopy and TEM, and helping with general lab support as needed under supervision.

Candidate must have familiarity with high-throughput automated systems, and a high level of aptitude for new technologies in X-ray instrumentation and diffraction methods.

Candidate must have excellent organizational, analytical, and record-keeping skills with the ability to organize and present technical reports to collaborators, IPD staff, management, and sponsors.

Candidate must be proficient with sterile laboratory maintenance, and familiar with BSL1 requirements.

Minimum Requirements:

  • B.S in Biochemistry + 3 months or more years of experience in related field
  • Candidates with knowledge in the use and maintenance of X-ray systems, familiarity with high-throughput automated systems, and X-ray diffraction methods.

    Desired Requirements:
  • Hands-on experience in the use and maintenance of X-ray systems
  • Experience protein crystallization and X-ray in-hose and Synchrotron data collection
  • Experience in Microscopy

    Application Process:
    The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process.  These assessments may include Work Authorization, Cover Letter and/or others.  Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page.  If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.

Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.


[Post Date: August 15, 2019]


Postdoctoral Fellow Position at UT Southwestern Medical Center on ‘Chromatin Structure and Epigenetics’

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Description:

A Postdoctoral Fellow position is available for a highly motivated researcher in Dr. Xin Liu’s group at UT Southwestern Medical Center.  The Liu Lab is also a core member of Cecil H. and Ida Green Center for Reproductive Biology Sciences.  The overarching goal of the Liu Lab is to understand the cellular regulation of dynamic chromatin structure, which is well known to impact both normal and disease development.  The Liu Lab is particularly interested in elucidating structure and function of large macromolecular assemblies that mediate formation of heritable high-order chromatin structure.  A current focus includes Polycomb Repressive Complexes, which modify histones, alter chromatin structure, and maintain cell identity during development.  To achieve the research goal, we leverage a combination of advanced research tools, including biochemical reconstitution (e.g. protein-protein, protein-nucleosome, and protein-non-coding RNA complexes), X-ray crystallography, cryo-EM, proteomics, and genomics by next-generation sequencing.  The study of structure-function relationships in the Liu Lab is typically carried out in a variety of cancer and pluripotent stem cells.  Additional information is available here: http://profiles.utsouthwestern.edu/profile/127166/xin-liu.html

Applicants with background or interest in structural biology, protein and nucleic acid biochemistry, and chromatin biology are encouraged to apply.  Trainees will have opportunities to learn the existing research tools in the lab as outlined above and will be encouraged to develop new cutting-edge tools as the project evolves.  Candidates must hold a Ph.D. and/or M.D. degree with first author publications and should submit a CV and contact information of 3 references to the PI by e-mail at: xin.liu@utsouthwestern.edu

UT Southwestern Medical Center is an Affirmative Action/Equal Opportunity Employer.  Women, minorities, veterans and individuals with disabilities are encouraged to apply.  UT Southwestern Medical Center offers extraordinary benefits for employees (more information is available here: https://jobs.utsouthwestern.edu/benefits.html). 


[Post Date: August 8, 2019]


Investigator II, Integral Membrane Proteins, CBT, Novartis

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Description:

We have an opening for a protein scientist to work in drug discovery projects where integral membrane proteins are the targets. Please see more information about the position and how to apply under the link above.


[Post Date: August 6, 2019]


Postdoc IBS, Grenoble, France

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Description:

A postdoc position is available in our lab at the Institute for Structural Biology (IBS) in Grenoble to study the structure of post-meiotic chromatin.

 

The work involves biochemistry, crystallography and cryo-EM and will take place at the IBS in close collaboration with the lab of Saadi Khochbin at the Institute for Advanced Biosciences.


[Post Date: August 5, 2019]