Banner Image

Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Postdoc Columbia University, Department of Biological Sciences, New York

job posting image

Description:

A Post-doctoral Research Associate position is available for structural studies on proteins involved in RNA processing and quality control, and other projects, using cryo-EM and crystallography. We have extensive experience in these areas, and have generated many high-impact publications (for example Science, 367, 700, 2020; Mol. Cell, 77, 800, 2020). Please visit our home page for more information http://tonglab.biology.columbia.edu/.

Strong experience in protein biochemistry is required. Prior experience with cryo-EM and/or X-ray crystallography is desirable.

Please send CV and names of three references to Liang Tong  ltong@columbia.edu.


[Post Date: February 6, 2023]


Postdoc University of Calgary

job posting image

Description:

A position is available for a highly motivated and skilled Post-doctoral Fellow (PDF) at the University of Calgary in Calgary, Alberta, Canada. The successful candidate will lead X-ray and potentially cryo-EM experiments to understand receptor complex biology and drug targeting. The position will be held within the Departments of Biological Sciences under the co-supervision of Dr. Matt (Mathilakth) Vijayan and Dr. Omid Haji-Ghassemi.

The successful applicant must have a Ph.D. in structural biology or related fields. Excellent theoretical knowledge and practical skills in either X-ray crystallography or other protein biophysical methods are required. This includes familiarity with the expression and purification of proteins.  The position forms part of a collaborative, multidisciplinary effort between the Vijayan and Haji-Ghassemi laboratories. As such, excellent oral and written English communication skills, the proven ability to work and as part of a team, and strong individual research productivity are essential.

Calgary is one of the sunniest and cleanest cities in North America. and has been named as one of the world’s most livable cities. Hence it is a great place to do research and build a career while living in an affordable city. Calgary is about an hour drive from the majestic Rocky Mountains and Banff. 

Qualified Applicants should submit a cover letter including contact information for three professional references, and a curriculum vitae including a list of publications. Application materials should be combined into a single PDF document and submitted via email to omid.hajighassemi@calgary.ca.

The position is available immediately. The appointment will be at the rank of Postdoctoral Fellow with a 50,000 salary, plus benefits.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any the basis of sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.


[Post Date: February 5, 2023]


Research Fellow in Integrative Structural Biology - Institute of Cancer & Genomic Sciences

View the Job Posting Here

job posting image

Description:

Position Details

Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences

Location: University of Birmingham, Edgbaston, Birmingham UK

Full time starting salary is normally in the range £32,348 to £42,155, with potential progression once in post to £44,737

Grade 7 

Full Time, Fixed Term contract for up to 3 years (2 posts)

Closing date: 21 February 2023

Background

The research group studies the functional mechanisms of proteins, nucleic acids and their complexes by integrative structural biology. The laboratory uses and develops high-field NMR spectroscopy methods as major structural biology tool, in combination with several other techniques. The Research Fellow will work in one of the following fields: RNA metabolism, regulation of gene expression, DNA repair, signalling. The post holder will use NMR spectroscopy, X-ray crystallography and/or Electron Microscopy, as well as Mass Spectrometry and Small Angle Scattering, to study the structure of protein–protein or protein–nucleic acids complexes and discover the mechanisms of their function and regulation. There are opportunities to develop new approaches to integrative structural biology with the combination of the techniques mentioned above. In addition, the Research Fellow will use molecular biology, biophysical and biochemical techniques to characterize biomolecular complexes and their activity in vitro and cellular biology approaches to verify the functional mechanisms in vivo. 

We are a group of highly motivated structural biologists with an interdisciplinary, international background. We offer a first-class research environment with state-of-the-art equipment in molecular biology and biochemistry and the best equipped biomolecular NMR facility in the UK (comprising 1000, 900 and 800 MHz spectrometers equipped with cryoprobes and MAS probes for both solution- and solid-state NMR spectroscopy). Excellent EM instrumentation is available at the Midlands Regional Cryo Electron Microscope Facility in Leicester. 

Role Summary

  • Work within specified research grants and projects and contribute to writing bids
  • Operate within area of specialism
  • Analyse and interpret research findings and results
  • Contribute to generating funding
  • Contribute to licensing or spin out deals with demonstrated commercial success (such as revenues, asset or company sales, IP generated) and/or public understanding of the discipline or similar.

Main Duties

The responsibilities may include some but not all of the responsibilities outlined below.

  • Develop research objectives and proposals for own or joint research, in the area of interest of the hosting laboratory (Prof T Carlomagno)
  • Contribute to writing bids for research funding
  • Acquire, analyse and interpret data - structural biology, biochemical and biophysical data
  • Apply knowledge in a way which develops new intellectual understanding
  • Disseminate research findings for publication, research seminars etc
  • Supervise students on research related work and provide guidance to PhD students where appropriate to the discipline
  • Contribute to developing new models, techniques and methods
  • Undertake management/administration arising from research
  • Contribute to Departmental/Institute research-related activities and research-related administration
  • Contribute to enterprise, business development and/or public engagement activities of manifest benefit to the College and the University, often under supervision of a project leader
  • Collect research data; this may be through a variety of research methods, such as scientific experimentation and literature reviews
  • Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
  • Deal with problems that may affect the achievement of research objectives and deadlines
  • Promotes equality and values diversity acting as a role model and fostering an inclusive working culture.

Person Specification

  • PhD (or near to completion) in Biophysics/ Biochemistry/ Chemical Biology/ Structural Biology or related areas. Or, equivalent qualifications
  • Proficiency in either biomolecular NMR spectroscopy or single-particle electron microscopy, both in data acquisition and analysis
  • Practical experience in a biochemical laboratory and/or handling nucleic acids
  • High level analytical capability
  • Ability to communicate complex information clearly
  • Fluency in relevant models, techniques or methods and ability to contribute to developing new ones
  • Ability to assess resource requirements and use resources effectively
  • Understanding of and ability to contribute to broader management/administration processes
  • Contribute to the planning and organising of the research programme and/or specific research project
  • Co-ordinate own work with others to avoid conflict or duplication of effort
  • Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day to day activity in own area that those with protected characteristics are treated equally and fairly
  • Willingness to work in a competitive, international environment

Informal enquires to Professor Teresa Carlomagno, email: t.carlomagno@bham.ac.uk

Further particulars can be found here.

Valuing excellence, sustaining investment

We value diversity and inclusion at the University of Birmingham and welcome applications from all sections of the community and are open to discussions around all forms of flexible working.


[Post Date: February 5, 2023]


Postdoc position available: Structural Biology of RNA-protein complexes

View the Job Posting Here

job posting image

Description:

A postdoctoral research position is available in the laboratory of Yunsun Nam Ph.D., in the Department of Biochemistry at the University of Texas Southwestern Medical Center, to study the mechanisms underlying RNA-protein complexes important for gene regulation. Our laboratory works on exciting projects dissecting how chemistry and structure contribute to assembling specific RNA-protein complex architectures important for normal gene expression, using structural biology and biochemistry. The RNA-protein complexes we study are relevant for normal development as well as diseases. As we unravel how dysregulated RNA-protein complexes derail gene expression and cause cancer, we use our mechanistic insights to identify novel therapeutic avenues.

Postdoctoral scholars will have opportunities to learn the newest methods in protein and nucleic acid biochemistry and biophysics, in addition to working in an exciting, fast-evolving field in biomedical sciences. We use various approaches, including cryo-electron microscopy (cryo-EM), X-ray crystallography, NMR spectroscopy, molecular biology, nucleic acid and protein biochemistry, genomics with next-generation sequencing, high-throughput screening for drug discovery, and cancer cell biology. The postdoctoral fellow will have ready access to the top-of-the-line equipment and resources necessary for the above approaches. For cryo-EM, we have ready access to four microscopes on our campus: two Titan Krios, one Glacios, and one Talos Arctica. Information on our postdoctoral training program, benefits, and a virtual tour can be found at http://www.utsouthwestern.edu/postdocs.

Candidates must hold a Ph.D. and/or M.D. degree. Experience in biochemistry and structural biology leading to publication in peer-reviewed journals is recommended. Interested individuals should send a CV, a statement of interest, and a list of three references as a single pdf file to: Yunsun.Nam@utsouthwestern.edu (Lab Website: www.ynamlab.org).

UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community.  As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status. 


[Post Date: January 30, 2023]


Structural Biologist - Vaccine Focus

View the Job Posting Here

job posting image

Description:

The structural biology and biophysical department in Stevenage continues to grow.  Already supporting small molecule and biotherapeutics we are adding a new team to concentrate on structural vaccinology working in close collaboration with vaccine research sites in Italy, Belgium and the US.

This role provides a fantastic opportunity for talented structural biologists, particularly those with cryo-EM expertise and an interest in vaccine development to join this vibrant department on a permanent, full-time basis.

The UK Structural & Biophysical Sciences group is a multi-disciplinary department within GSK R&D that provides molecular insights into medicine discovery for small molecule, biopharmaceutical and now vaccine programs. We are founding members of the Cambridge Pharmaceutical cryo-EM consortium with access to two state-of-the-art ThermoFisher maintained Krios systems. In house our EM suite with a Glacios with a Falcon 4i will soon be joined by an additional Glacios2.  Together with Leica and Vitrobot sample preparation stations, high-performance computing infrastructure and an array of biophysical techniques (mass photometry, structural mass spectrometry, FIDA, SPR) the department works in unison and across many modalities to generate molecular insights that help progress projects from concept to medicines.

We are looking for group members with demonstrated success in structural biology including cryo-EM ideally applied to vaccine or antibody research to join this new group. To be successful you will have broad knowledge and practical expertise in single particle cryo-EM, cryo-ET or X-ray crystallography, especially on membrane protein targets. Motivated to work within a team environment you will want to apply your talents to drive impact on drug discovery projects by working closely with others. With a passion to remain current in this rapidly moving area, you are likely to have exceptional strengths in one ore more specific aspects of EM.  Whether this be instrument knowledge, challenging sample optimisation, skills in software development and processing, or creativity in addressing complex problems, we are keen to understand the abilities that set you apart!

Recognising the value of maintaining excellence GSK supports individual career paths and personal development planning. Our goal is to build diverse teams that work together to address key drug discovery challenges with the best scientific insights possible.

In this role you will

  • Deliver structural data and insights across global portfolio of vaccine projects to inter-disciplinary teams.
  • Liaise and consult as a structural & biophysics representative to vaccine program teams.
  • Manage interactions with multiple projects and be influential in prioritize across your individual and the wider department activities
  • Maintain scientific excellence in a rapidly evolving area e.g. through interactions such as the ThermoFisher/LMB/Pharma consortium.
  • Maintain connectivity with external science community to stay abreast of science developments.
  • Act as an ambassador for GSK science externally through publications and scientific engagement.

Why you?

Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

  • Background in a biological, biochemical, or physical sciences discipline, with PhD level or equivalent experience.
  • Knowledge of all stage’s single particle cryo-EM process from protein purification to grid optimisation, data-processing, 3-D reconstruction, and structure interpretation.
  • Demonstrated exceptional track record of success and expertise in at least one specific area of the cryo-EM process.
  • Experience with the operation of screening and high-resolution data-collection microscopes.
  • Success with high-resolution structure determination especially of small proteins, membrane proteins, or antibody/antigen complexes.
  • Excellent organisational skills.
  • Strong interpersonal, communication and team working skills.

Preferred Qualifications & Skills:

If you have the following characteristics, it would be a plus:

  • Postdoctoral/industrial experience in structural biology.
  • Strong track record of publications in peer reviewed journals, or patent filing
  • Interest in vaccine and antibody research
  • Ability to integrate EM data with data from other biophysical techniques.
  • Experience with protein expression and purification, particularly membrane proteins.
  • Practical expertise in cryo-ET, X-ray or other biophysical methods.
  • Experience of scientific leadership to influence programs of research.
  • Ability to coordinate projects with interconnecting activities.

Closing Date for Applications: 17th February 2023 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert. 

When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.  If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

Why GSK?

Uniting science, technology and talent to get ahead of disease together

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

Find out more: 

Annual Report 2021

R&D

We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.

In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention.

Find out more:

Our approach to R&D   

*LI-GSK

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Ukdiversity.recruitment@gsk.com or 0808 234 4391.  Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it.  Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.


[Post Date: January 30, 2023]


Group Leader Structural Vaccinology

View the Job Posting Here

job posting image

Description:

The structural biology and biophysical department in Stevenage continues to grow.  Already supporting small molecule and biotherapeutics we are adding a new team to concentrate on structural vaccinology working in close collaboration with Vaccine research sites in Italy, Belgium and the US.

This provides a fantastic opportunity for talented structural biologists, particularly those with cryo-EM expertise and an interest in vaccine development to join this vibrant department on a permanent, full-time basis. We are looking for a Group Leader to head up this new structural vaccinology group.

The UK Structural & Biophysical Sciences group is a multi-disciplinary department within GSK R&D that provides molecular insights into medicine discovery for small molecule, biopharmaceutical and now vaccine programs. We are founding members of the Cambridge Pharmaceutical cryo-EM consortium with access to two state-of-the-art ThermoFisher maintained Krios systems. In house our EM suite with a Glacios with a Falcon 4i will soon be joined by an additional Glacios2.  Together with Leica and Vitrobot sample preparation stations, high-performance computing infrastructure and an array of biophysical techniques (mass photometry, structural mass spectrometry, FIDA, SPR) the department works in unison and across many modalities to generate molecular insights that help progress projects from concept to medicines.

We are looking for an experienced leader with demonstrated success in structural biology including cryo-EM ideally applied to vaccine or antibody research to head this new group. A skilled collaborator able to work within interdisciplinary local and remote teams. You will have many examples of personal scientific contributions and be able to support others in maximizing their research excellence and career development. Our goal is to build diverse teams that work together to address key drug discovery challenges with the best scientific insights possible.

In this role you will

  • Manage and support a team of structural biologists to optimize the impact of the team’s deliverables on the GSK’s vaccine portfolio.
  • Design and implement project strategies contributing to portfolio of bacterial, viral and mRNA vaccine development.
  • Identify key decision points and manage risk and expectations to meet short and long-term objectives successfully.
  • Liaise and consult as a structural & biophysics representative to vaccine program teams.
  • Proactively communicate across local and global interfaces, including project strategy, critical issues, and recommendations to enable appropriate resource decisions.
  • Act as an ambassador for GSK science externally through publications and scientific engagement.

Why you?

Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

  • Ph.D. or equivalent in relevant field and extensive postdoctoral experience.
  • Strong, independent research background in structural biology ideally including both X-ray and cryo-EM expertise.
  • Knowledge and hands on experience with all steps necessary to generated high resolution structures including for antibody, protein and/or small molecule complexes.
  • Demonstrated track record of innovation and delivery with successful integration of biological and biophysical information to give biological insights.
  • Leadership experience both with direct reports and within matrix projects.
  • Highly organised and collaborative with the ability to implement effective frameworks to lead an integrated team within a highly matrixed environment.
  • Strong interpersonal, communication and team working skills with experience of working with remote collaborations.
  • Expertise in immunology, vaccine, or antibody research.

Preferred Qualifications & Skills:

If you have the following characteristics, it would be a plus:

  • Postdoctoral/industrial experience in structural biology.
  • Strong track record of publications in peer reviewed journals, or patent filing
  • Ability to integrate EM/X-ray data with data from other biophysical techniques.
  • Practical expertise in cryo-ET or other biophysical methods.
  • Experience of scientific leadership to influence programs of research.
  • Examples of training scientists in one or more areas of the cryo-EM process.

Closing Date for Applications: 17th February 2023 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert. 

When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.  If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

Why GSK?

Uniting science, technology and talent to get ahead of disease together

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

Find out more: 

Annual Report 2021

R&D

We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.

In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention.

Find out more:

Our approach to R&D   

*LI-GSK

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Ukdiversity.recruitment@gsk.com or 0808 234 4391.  Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it.  Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

 


[Post Date: January 30, 2023]


Postdoctoral Research Associate in Structural Molecular Biology

View the Job Posting Here

job posting image

Description:

Department: School of Biological & Behavioural Sciences
Salary: £35,411 - £36,348 (Grade 4)
Reference: QMUL31224
Location: Mile End
Date posted: 16 December 2022
Closing date: 19 February 2023

About the role

Applications are invited for two Postdoctoral Research Associates with expertise in structural biology to join the research group of Aravindan Ilangovan at Queen Mary University of London. These Wellcome Trust Funded posts will be based at the Centre for Structural Biology within the School of Biological and Behavioural Sciences (SBBS) at Queen Mary.

The project is focused on the molecular mechanism of DNA replication initiation in bacteria. Together with the laboratory of Prof. Heath Murray at Newcastle University, this work is aimed at unravelling the sequence of events that lead to helicase loading during initiation and restart. This structural biology project will take advantage of the expertise in the lab working with nucleoprotein complexes aided by dedicated cryo-EM and X-ray crystallography facilities. The group has routine access to the Titan Krios microscopes at LonCEM and eBIC and an in-house computing infrastructure for data processing.

About You

We are seeking two ambitious individuals to develop, drive and deliver their research project, while working with other members of the Ilangovan group and our collaborators on a regular basis. Candidates must have a meticulous approach to data collection, analysis and preparing manuscript for publication. A demonstrated ability to communicate well, work within a team, and deliver projects within an agreed timeframe is also essential. Evidence of high-impact publication in structural biology or a related field is desirable.

Benefits

We offer competitive salaries, access to a generous pension scheme, 30 days’ leave per annum (pro-rata for fixed-term), a season ticket loan scheme, staff networks and access to a comprehensive range of personal and professional development opportunities. In addition, we offer a range of work-life balance and family-friendly, inclusive employment policies, flexible working arrangements, and campus facilities including an on-site nursery at the Mile End campus.

The post is full-time (35 hours) and fixed term for 3 years, with the possibility of an extension thereafter. The expected start date is 1st March 2023 or soon as possible thereafter. The salary is in the range of £35,411 - £36,348 per annum pro-rata and is inclusive of London Allowance.

Informal enquiries should be addressed to Aravindan Ilangovan via: a.ilangovan@qmul.ac.uk. Details about SBBS can be found at https://www.qmul.ac.uk/sbbs/

The closing date for applications is 19th February 2023. Interviews are expected to be held shortly thereafter. 

To apply for the role please click the link below. With their CV, candidates should include a one-page statement explaining how they might be able to contribute with their experience to the project as outlined above.

Queen Mary’s commitment to our diverse and inclusive community is embedded in our appointment processes. Reasonable adjustments will be made at each stage of the recruitment process for any candidate with a disability.

Valuing Diversity & Committed to Equality


[Post Date: January 30, 2023]


Research/Sr Research Associate--Northeast Collaborative Access Team (NE-CAT), Cornell University (Argonne, IL)

View the Job Posting Here

job posting image

Description:

As part of the university's comprehensive vaccination program, all Cornell employees are required to have and provide proof of an FDA-or WHO-authorized or approved COVID-19 vaccine and booster or have obtained a university-approved disability/medical or religious exemption, regardless of their role and work location.

New hires are required to provide documentation showing full vaccination status (that is, completion of two shots of the Moderna or Pfizer vaccine or one shot of the Janssen/Johnson & Johnson) before their first day of work. If a new hire's vaccination is not complete or information is not received by their start date, the first day of work will be delayed. It is possible in some cases that an offer of employment may be withdrawn.

For additional information on Cornell's Vaccination/Booster Compliance Program click here.

The Northeastern Collaborative Access Team (NE-CAT), located at the Advanced Photon Source at the Argonne National Laboratory in suburban Chicago, is seeking applicants for a Staff Scientist position at the Research Associate and Sr. Research Associate levels.  Primary responsibilities will be to provide training and support to users of NE-CAT’s two state-of-the-art X-ray beamlines, provide crystallographic expertise to ensure the highest quality data and structures, and contribute to the continued development of beamline software tools.

The prospective applicant will collaborate with other NE-CAT team members to enhance and extend the capabilities of the NE-CAT beamlines – ideally contributing to the continued development of software tools that improve the user experience at NE-CAT and will be expected to take initiative and contribute to the team effort in an inclusive and respectful environment. To be considered for the Senior Research Associate level, a candidate should have significant experience managing synchrotron beamlines as well as advanced experimental and programming capabilities.

Duties and Responsibilities:

  • Provide user training and support, both onsite and via remote conferencing. This involves work nights and weekends, approximately nine months of the year, when the APS has run cycles and is open for data acquisition. During these months, the staff scientist will rotate assignments with other staff members to provide support 24 hours a day, seven days a week.
  • Use existing crystallographic software: CCP4, PHENIX, XDS, etc. to assist users in data collection, processing, and structure solution. Test and develop modifications as necessary. This requires familiarity with Linux and programming.
  • Test and debug new beamline hardware and software. Evaluate beamline performance to produce optimum data.
  • Use knowledge of synchrotron beamline optics and experiment-specific methods to develop data collection and structure determination procedures for current projects and new techniques including microcrystals, room temperature data collection, and serial crystallography.
  • Contribute to the continued development of remote data collection and real time data analysis software for the beamline data acquisition systems.
  • Collect data on macromolecular crystals for structure solution, model building, and refinement.
  • Participate in cooperative research in which the scientist's expertise is combined with that of members of the NE-CAT user community to improve the processes of protein purification, crystallization, and determination of macromolecular structures.
  • Publish results and help prepare presentations and documentation to disseminate information about advances to the macromolecular crystallography community.

Related Duties:

  • Provide advice and consultation to users and technical support staff.
  • Assist in preparation of research grant proposals and annual reports.
  • Attend and participate in seminars and scientific meetings.
  • Recommend equipment and supplies necessary to further research associated with the mission of the facility.
  • Collaborate with team members who develop user safety procedures, calibration procedures, data collection procedures, and both on-line and standard documentation.
  • Assist technical staff with beamline hardware troubleshooting and maintenance as needed.

Qualifications:

  • Doctorate in Biochemistry, Structural Biology, Biophysics, Chemistry, or related field.
  • At least three years doctoral or post-doctoral experience involving macromolecular crystallography. Record of publications of research in the scientific literature.
  • Fluency in the English language, written and oral.
  • Experience operating and managing synchrotron beamlines.

For more information about NE-CAT, please see our website:  https://necat.chem.cornell.edu

This is a 12-month benefits eligible full-time (100%FTE) appointment term which is renewable depending on funding and performance.

Salary:  commensurate with experience

Start:  March 1, 2023

Applications will be reviewed as they are received and will be accepted until the position is filled.  Please direct questions to Frank Murphy, NE-CAT Associate Director (fvm3@cornell.edu).  Application Deadline February 28, 2023.

Application Materials Required:

Submit the following items online at this website to complete your application:
  • Cover letter
  • Curriculum Vitae
  • Copies of Relevant Publications
  • Contact Information for 3 References
And anything else requested in the position description.


Further Info:

http://chemistry.cornell.edu/
 
Department of Chemistry and Chemical Biology
122 Baker Laboratory
Cornell University
Ithaca, NY 14853-1301

 Download PDF

[Post Date: January 25, 2023]


Postdoctoral Positions – Structural Mechanisms of Genome Maintenance Vanderbilt University

View the Job Posting Here

job posting image

Description:

Description

Multiple NIH-funded postdoctoral positions are available in the laboratory of Dr. Brandt Eichman at Vanderbilt University to study molecular mechanisms of enzymes involved in DNA replication-repair. Projects include (1) repair and tolerance of DNA damage during replication, (2) resolution of stalled replication forks, (3) replication initiation, and (4) base excision repair of interstrand DNA crosslinks. We integrate the tools of structural biology, including cryo-EM, X-ray crystallography, and computational modeling, with in vitro biochemistry, biophysics, chemical and cell biology, and genetics to investigate the structure-function relationship of DNA processing enzymes and their macromolecular complexes.

The environment

Lab members are part of a collaborative, multidisciplinary, and inclusive team of investigators and trainees interested in DNA replication and repair. Fellows are trained in multiple disciplines and take advantage of state-of-the-art shared research facilities, including new cryo-EM and X-ray crystallography instrumentation. Scientific growth and professional development opportunities beyond the PI’s laboratory are provided by the Genome Maintenance program within the Vanderbilt-Ingram Cancer Center, the Molecular Biophysics training program within the Center for Structural Biology, and other NIH-supported training grants. The PI’s laboratory is committed to fostering a diverse and inclusive environment and welcomes applications from marginalized groups.

Vanderbilt University is located in the heart of Nashville, Tennessee, which is consistently rated as one of the best cities in the US in which to live and work.

Stipend

Salaries follow the NIH NRSA stipend scale. Additional information on benefits and being a postdoc at Vanderbilt University can be found at https://www.vanderbilt.edu/postdoc/.

Applicants

A Ph.D. in biochemistry, molecular biology, or a related discipline, and at least one first-author publication are required. Experience in cryo-EM, nucleic acid manipulation, and/or single-molecule techniques are highly desirable. The successful candidate will have a demonstrated productivity in protein biochemistry; have excellent organizational, interpersonal, and communication skills; and be willing take research risks and motivated to learn new techniques.

To apply

Email CV, a cover letter detailing your research interests and career goals, reprints of recent publications, and names of 3 references to brandt.eichman@vanderbilt.edu.

Contact

Brandt Eichman, Ph.D.

brandt.eichman@vanderbilt.edu

Phone: 615-936-5233

http://structbio.vanderbilt.edu/eichman/


[Post Date: January 24, 2023]


Crystallographer Position at CHARM Therapeutics

View the Job Posting Here

job posting image

Description:

CHARM Therapeutics is a biotech company focused on delivering transformational medicines that will address difficult-to-drug targets in key oncogenic pathways. CHARM has developed the first highly accurate, high throughput protein-ligand co-folding algorithm (DragonFold), driven by end-to-end 3D deep learning. Our platform enables the rapid generation of highly differentiated clinical candidates, and our ambition is to revolutionise drug discovery.  CHARM Therapeutics is establishing a state-of-the-art R&D facility in Cambridge, UK.

We are currently seeking a motivated Protein Crystallographer to join the Structural Sciences group at CHARM Therapeutics. The position is within a lab-based team, working on high throughput crystallographic and CryoEM structural targets to fully enable and drive multiple SBDD / Med Chem campaigns. The successful candidate will join a multidisciplinary, highly collaborative discovery team to invent novel medicines and drive them towards the clinic.

Role Requirements:

  • A degree in biochemistry / biophysics / structural biology, or a related discipline, is required
  • Experience in a biotech/pharma setting may be advantageous
  • Experienced in setting up and optimising crystallisation experiments using robotics, and harvesting crystals
  • Experience with working in a high throughput fragment screening environment would be advantageous.
  • Experience in crystallographic data processing and refinement using XDS, CCP4 and Global Phasing software suites would be beneficial and experience in data analysis using the PANDDA approach would be an advantage.
  • Demonstrable wet lab skills including protein expression and purification for crystallography purposes
  • Excellent organisational / interpersonal skills with the ability to work as part of a team

What is on Offer

  • The chance to work in a highly collaborative, progressive and intellectually stimulating environment, applying state of the art AI-based techniques to revolutionise drug discovery
  • Competitive base salaries offered with regular appraisals and reviews
  • Share options in CHARM Therapeutics through the EMI scheme
  • Private Healthcare, including dental and optical
  • Gym membership
  • Budget for employee development; training courses and conferences
  • Fruit and snacks delivered to our offices


[Post Date: January 22, 2023]


Postdoctoral Scientist – Protein Biochemistry & Structural Biology

View the Job Posting Here

job posting image

Description:

Target Discovery Institute, NDM Research Building, Old Road Campus, Heading, Oxford, OX3 7BN
Contact Person : Kristina Limbu Vacancy ID : 162995
Contact Phone : 01865-617971 Closing Date & Time : 10-Feb-2023 12:00
Pay Scale : STANDARD GRADE 7 Contact Email : recruitment@ndm.ox.ac.uk
Salary (£) : Grade 7: Salary in range £34,308 - £42,155 per annum

 Download PDF

[Post Date: January 22, 2023]


Postdoc in Membrane Protein Structural Biology Lund University

job posting image

Description:

Work profile:

The successful applicant will perform experimental research to understand how membrane proteins belonging to the TRP-channel family are regulated in normal and pathophysiology using single particle cryo-EM. You should be creative, with good interpersonal and collaborative skills, power of initiative, and a high degree of independence. In particular, it is preferred if you master cloning, production, purification and analysis of membrane proteins as well as sample preparation, data collection, processing and analysis for determination of cryo-EM structures. The research will be supervised by Prof. Peter Zygmunt in collaboration with Assoc. Prof. Pontus Gourdon.

Selected publications from 2022 & 2021 from the two groups:

  • Zhang et al (2022) Nature Communications 13(1):7483
  • Moparthi et al (2022) Nature Communications 13(1):6113
  • Salustros et al (2022) Nature Communications 13(1):5121
  • Li et al (2022) Nature Communications 13(1):4339
  • Wiuf et al (2022) Science Advances 8, eabn4331
  • Grønberg et al (2021). Elife 10:e73124
  • Li et al (2021) Nature Communications 12(1):3973
  • Wang et al (2021) Nature Communications 12(1):2956

Preliminary start date:

As soon as possible

Supervisor/contact person:

Peter Zygmunt, +46 (0)46-222 69 06, peter.zygmunt@med.lu.se

Pontus Gourdon, +46 (0)739-95 98 56, pontus.gourdon@med.lu.se

(Preferred) qualifications:

  • To candidate must hold a PhD degree within a relevant field, and the degree cannot be older than three years.
  • Experience of cloning, production and purification of membrane proteins.
  • Experience of single particle cryo-EM on membrane proteins including the preparation and freezing of protein samples.
  • Experience of screening samples using “state-of-the-art” electron microscopes such as Talos, Glacios and Krios.
  • Experience of publication of cryo-EM structure studies.
  • Experience of interdisciplinary collaborations.
  • Excellent knowledge of written and spoken English.

Written application, including reference number, is to be sent via e-mail to the supervisors and must include the following:

  • CV
  • Personal letter stating the reasons why the study suits the applicant (maximum one page)
  • List of publications
  • References (2)
  • Indicate the reference number (V2022/1491) in the email and in the attached application


[Post Date: January 22, 2023]


Tenure-track Group Leader Position in Structural Biology - FMI, Basel, Switzerland

View the Job Posting Here

job posting image

Description:

The Friedrich Miescher Institute for Biomedical Research (FMI) invites applications for a tenure-track group leader position (assistant professor level) in Structural Biology. We encourage applications from candidates who have an innovative research program focused on mechanistic questions that are related to genome regulation, RNA metabolism, or protein homeostasis. We particularly welcome applications from individuals using cutting-edge structural biology approaches.

The position includes a generous start-up package including core funding, relocation expenses, and access to state-of-the-art core facilities. The institute also provides a career mentoring program and assistance with research grant applications. Our vibrant, English-speaking scientific environment offers opportunities for multidisciplinary collaboration with FMI research teams in our focal areas: Genome Regulation, Multicellular Systems and Neurobiology.

The FMI is a world-class biomedical research institute affiliated with the University of Basel and the Novartis Institutes for Biomedical Research. The institute has an international staff of around 330 people from more than 40 countries, including more than 170 postdoctoral fellows and graduate students. The FMI is located in Basel, the third largest city in Switzerland, which has a vibrant cultural scene and is conveniently situated on the borders with France and Germany. Basel is the leading European hub for life sciences with many opportunities in academia, as well as pharmaceutical and biotechnology companies. The city is home to a diverse international population and has several multilingual schools.

The FMI is committed to increasing the diversity of our faculty and strongly encourages people from under-represented groups to apply. We offer a family friendly work environment and are responsive to the needs of dual career couples.

Applications − including a CV, a concise description of research interests and future plans, as well as contact details of three referees − should be submitted to: www.fmi.ch/gl_search

Applications close on March 19, 2023. Shortlisted candidates will be invited to a symposium and chalk talk at FMI scheduled for the week of Jun 26, 2023.

For informal inquiries please contact:
Marc Bühler (marc.buehler@fmi.ch), Jeff Chao (jeff.chao@fmi.ch) or Dirk Schübeler (dirk.schubeler@fmi.ch), FMI Director


[Post Date: January 22, 2023]


Postdoc Stockholm University

View the Job Posting Here

job posting image

Description:

In the Stenmark group at Stockholm university, we are looking for a new postdoc with expertise in macromolecular crystallography. 

The successful applicant will be involved in multiple high-profile studies investigating human enzymes involved in nucleotide metabolism, which are the targets of structure-based drug design programs.

Details about the position and a link to the application system can be found here https://www.su.se/english/about-the-university/work-at-su/available-jobs?rmpage=job&rmjob=19944&rmlang=UK

The deadline for applications is the 16th of February 2023. 


[Post Date: January 22, 2023]


Postdoctoral position in Structural Biology at the University of Toronto

job posting image

Description:

We are seeking an enthusiastic and self-motivated Postdoctoral Fellow to study the mechanisms of fertilization and cell-cell fusion in the Lee Lab at the University of Toronto, Department of Laboratory Medicine and Pathobiology. The Postdoctoral Fellow will lead research efforts on a Bill and Melinda Gates Foundation funded project to develop non-hormonal contraceptives targeting essential membrane glycoproteins involved in human sperm and egg attachment. The research will entail protein-protein interaction studies, crystallography, protein engineering, and/or cryo-EM.

 

Qualifications:

  • PhD in Biochemistry, Structural Biology, Biophysics, or a related field
  • Experience with cloning, protein expression, and protein purification methods
  • Experience with insect or mammalian cell culture is a benefit
  • Solid practical and theoretical understanding in X-ray crystallography and/or cryo-EM
  • Strong publication record
  • Fluent in English (written and oral)
  • Strong scientific writing skills
  • Excellent problem solving, interpersonal, communication and presentation skills

The position is available immediately. University of Toronto is well equipped with state-of-the-art equipment for molecular biology, protein expression and purification, biophysics and structural biology (crystallography, NMR and cryo-EM). Please visit the Lee Lab website (https://www.leelab-utoronto.com) for more information.

Interested candidates are invited to send your CV, a brief description of research interest and experience, names of three references by email to: Prof. Jeff Lee

jeff.lee@utoronto.ca All qualified candidates are encouraged to apply by February 10, 2023. We thank all applicants for their interest, however only those shortlisted for interviews will be contacted.


[Post Date: January 22, 2023]


TT Assistant/ Associate Professor Pharmacology

View the Job Posting Here

job posting image

Description:

The Department of Pharmacology at Case Western Reserve University invites applications for tenure-track faculty or tenured faculty positions. The department has a long tradition of groundbreaking discoveries in basic science and medicine. Current areas of research expertise within the department include molecular oncology, therapeutics development in oncology and other diseases, visual sciences, and structural biology. Synergy exists with other interdepartmental research centers throughout the university including the Case Comprehensive Cancer Center and Cleveland Center for Membrane and Structural Biology. The department has vigorous interdisciplinary graduate programs (MS and PhD), and actively engages in medical and dental education. Graduate education is supported by two NIH sponsored training grants administered within the department. The Department of Pharmacology offers competitive startup packages, excellent laboratory space and core facilities, and a highly collaborative environment.  

Minimum Qualifications: Candidates should have a PhD and/or MD with a strong record of research accomplishments. Successful candidates are expected to develop innovative and externally funded research programs, participate in departmental education programs, and contribute to service opportunities. Candidates at the Assistant Professor level will have significant postdoctoral research experience with the potential for developing an extramurally funded and nationally recognized research program, while candidates at the Associate Professor level will have a funded and nationally recognized research program. Rank and tenure designation will be commensurate with experience.

How to Apply: Please send a cover letter for your application, curriculum vitae, description of research plan (3-5 pages), statement of commitment to diversity, and contact information for 3 references to:

            Pharmacology Faculty Search Committee
            apply.interfolio.com/118604

Applicants for an Assistant Professor position should arrange for references to send recommendation letters separately to the same address. Review of applications will begin immediately and continue on a rolling basis. The candidate’s diversity statement should address how their research, teaching, or service have contributed to diversity, equity and inclusion within their scholarly field. Questions may be directed to pharmfacsearch@case.edu.

Case Western Reserve University is committed to Equal Opportunity and Diversity. The University is dedicated to fostering an environment of inclusive excellence. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are strongly encouraged to apply.

Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216.368.3066 or equity@case.edu to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis. 


[Post Date: January 22, 2023]


Open postdtoctoral position - University of California Davis!

job posting image

Description:

The Shabek lab is looking for a postdoctoral fellow with a strong background in structural biology to join immediately to our research group at the University of California, Davis (shabek-lab.ucdavis.edu/).

We use structure- function approaches to study unique signaling pathways and their regulation by the Ubiquitin Proteasome System. We have several new funded projects by NSF and DOE.  

Qualifications:

  • Must be a recent Ph.D. in Biochemistry and/or Plant Biology and/or Structural Biology • Experience in molecular biology, protein purification techniques (experience with baculovirus expression is preferred but not required), and protein-protein/molecule interactions.
  • Experience in structural biology (X-ray crystallography and/or Cryo-EM) is preferred.
  • Strong communications skills and ability to train junior scientists

Compensation and benefits for postdocs in UC Davis are the highest in the country.

Davis is a beautiful Californian town located near Sacramento, and close to San Fransisco, and several National Parks.

The Shabek lab has all the advance tools and equipment to conduct structural biology experiments. We have access to ALS bemalines in Berkeley and SSRL in Stanford, as well as CryoEM facilities (BioEM in Davis or Brookhaven National labs). 

To apply:

Email directly to Dr. Nitzan Shabek (nshabek@ucdavis.edu) with the subject line: Postdoc in Structural Biology Application. 

Please include a cover letter that highlights your research experience & interests, CV, and contact information of 2-3 references.

(please use your institutional email, if possible, otherwise it may go to spam)


[Post Date: December 30, 2022]


Open Postdoctoral Position: Structural biology of the actin cytoskeleton

job posting image

Description:

Djinovic lab is interested in the molecular mechanisms underlying the architecture and assembly of the actin based cytoskeleton. This project focuses on ubiquitous human proteins α-actinin-1 and -4, which self-associate to form a homo- and hetero dimeric units that cross-link actin filaments in calcium-regulated manner. The project is jointly funded by Austrian and Slovene Science Funds and is a close collaboration between Djinovic group at Vienna, Austria, and Pavsic group at University of Ljubljana, Slovenia. The two young and dynamic groups will join forces to understand the detailed molecular mechanism of regulation of this essential F-actin crosslinking protein by calcium and specific phosphoprylation events.

We employ an integrated approach by combining biochemistry, cell, chemical and structural biology approaches, including X-ray crystallography, small angle scattering and (starting) cryo-EM. The successful candidates will be involved in all aspects of the project, including protein expression, purification, biophysical, biochemical characterization and integrative structural biology.

Qualifications and experience: The applicants should hold a PhD degree in a relevant field and two years of post-doctoral experience in a structural biology lab. Strong background in molecular cloning, expression, and purification of protein complexes is essential. Prior knowledge of crystallography and/or single-particle electron microscopy is needed. Excellent spoken and written English are required.

The successful applicants will work in a stimulating scientific environment: Department for Structural and Computational Biology at Max Perutz Labs, a joint venture between University of Vienna and Medical University of Vienna. The Labs are located at Vienna BioCenter, the largest molecular life science hub in Austria. We are equipped equipped with state-of-the-art research infrastructure for experimental and computational work, and have access to facilities at Vienna Biocenter Core Facilities, which includes mass-spectrometry, a blend of Protein technologies and electron microscopy instruments (Glacios, Krios). The group has in addition access to cryo-EM Titan-Krios through BAG at ESRF and to major European synchrotron high-brilliance X-ray sources.

  1. A concise description of research experience, including a list of published peer-reviewed articles.
  2. Copy of the PhD diploma (or equivalent).
  3. Contact details for three references, of which one should be your PhD supervisor.

Please prepare the application as a single package in PDF format, and send it to <admin.vbc5@univie.ac.at>, subject Postdoctoral position in Djinovic Lab.

Further information can be obtained from Kristina Djinovic Carugo  kristina.djinovic@univie.ac.at.

Closing date: review of applications begins immediately and will continue until the position is filled.


[Post Date: December 19, 2022]


Postdoctoral Research Associates at Oak Ridge National Laboratory

job posting image

Description:

We have two immediate openings for Postdoctoral Research Associates at Oak Ridge National Laboratory:

Position 1: We are seeking a Postdoctoral Research Associate in structural biology of enzymes degrading recalcitrant natural and synthetic polymers. The Postdoctoral Research Associate will join a multi-disciplinary research team that uses enzyme engineering and neutron/X-ray/electron diffraction to understand structural features that determine activity and design enzymes with improved efficiency. As an ORNL postdoctoral fellow you will have access to state-of-the-art facilities for biochemical characterization and X-ray diffraction, as well as access to world class facilities for neutron and electron diffraction.

Applicants should have received a Ph.D. in biochemistry, structural biology, chemistry or related science field within the last five years and should have extensive experience in protein purification and biochemical characterization.

To apply: https://jobs.ornl.gov/job/Oak-Ridge-Postdoctoral-Research-Associate-Protein-Biochemistry-and-Structural-Biology-TN-37830/965904500/

Position 2: We are seeking a Postdoctoral Research Associate to characterize the structure and dynamics of enzymes immobilized on biopolymer matrices using X-ray and neutron scattering techniques.

Applicants should have received a Ph.D. in material science, bioengineering, structural biology, chemistry or related science field within the last five years and should have experience in X-ray and/or neutron scattering techniques.

The project is part of the Biocatalysts Interactions with Gases (BIG) international collaboration (https://sites.textiles.ncsu.edu/big/), with  partners at North Carolina State University (NC State), Technical University of Denmark (DTU), and  Oak Ridge National Laboratory (ORNL). The candidate will join the Neutron Scattering Division at ORNL and will work closely with collaborator and ORNL’s Weinberg Distinguished Staff Fellow Dr. Yue Yuan at the Center for Nanophase Material Science.

To apply: https://jobs.ncsu.edu/postings/174730


[Post Date: December 14, 2022]


Established Investigator - Structural Biology of Age Related Diseases

job posting image

Description:

The Hauptman-Woodward Medical Research Institute (HWI) (https://hwi.buffalo.edu) seeks an established investigator to join the scientific efforts at the Institute. Applications in the broad areas of structural, computational, or molecular biology are solicited.  The Institute seeks exceptional candidates who will direct an independently funded research program in important areas of human biology, health or disease, with a preferred emphasis on neurodegeneration and diseases of aging – healthy life extension.  The Institute houses the National Crystallization Center, its own Cryo-EM facility, and operates a beamline at the Advanced Photon Source. Preference would be given to candidates that could make good use of one or more of these facilities. Candidates are expected to have a Ph.D. or equivalent in a relevant field and a strong record of scientific productivity, and extramural funding.

HWI is celebrating 65 years as an independent research institute and expects to make several new hires over the next few years.  Located in Buffalo, New York, HWI is at the heart of the Buffalo-Niagara Medical Campus and partners with the University at Buffalo, Roswell Park Comprehensive Cancer Center, and other institutions. The University is also recruiting in the areas of cryo-EM and computational biology extending the local intellectual community. HWI also has a generous intellectual property sharing policy for candidates with entrepreneurial interests.

Interested candidates should submit, as a single PDF file, a complete curriculum vitae, a statement of research accomplishments, an outline of current and future research, and arrange for three letters of recommendation to be sent either to Search Committee, Hauptman-Woodward Institute, 700 Ellicott Street, Buffalo, NY  14203, or by email to opportunity@hwi.buffalo.edu.  The search will remain open until filled.  Applications received by 10/31/2022 will be considered in the initial evaluation. Please note the required criteria and application instructions.


[Post Date: December 8, 2022]


Postdoctoral position in Structural Virology at the Institut Pasteur

job posting image

Description:

A two-year postdoctoral position is available in the group of Structural Biology of Infectious Diseases (SBID) at the Institut Pasteur (Paris, France)

SBID is a new lab at the Institut Pasteur headed by Pablo Guardado-Calvo. In the SBID we investigate the molecular mechanism of poxvirus entry into target cells. We combine structural biology, biophysics and virology approaches to characterise protein complexes. We aim to use the resulting information to develop vaccines and therapies. For more information, you can check our previous work done with bunyaviruses and flaviviruses (PMIDs: 32937107, 29097548, 27783711, 25581790).

We are looking for a person with excellent track record and motivation to pursue a career in structural virology. The postdoctoral fellow will be in charge of characterising large protein complexes using cryo-electron tomography or SPA and of setting up functional assays to characterise their activity in vitro. The postdoc will work in close collaboration with a research engineer focused on related projects. The project will involve protein and virus production, functional characterisation of ligands using neutralisation and fusion assays and structural studies using cryo-electron microscopy and crystallography. The group is hosted in friendly and dynamic environment with extensive opportunities to learn new techniques and establish collaborations. We have fully equipped P1 and P2 labs and the Institut Pasteur is equipped with start-of-the-art microscopes, including two 200 kV Glacios and a 300 kV Titan Krios equipped with a Falcon 4 detector and an energy filter. The synchrotron Soleil is less than 1 hour from the Institut and we have fluid access to the crystallography and biophysics platforms, which are excellently equipped.

Required qualifications
• A PhD in structural biology, biochemistry, biophysics or virology.
• Documented experience in at least one of the following techniques: structural biology (cryo-electron microscopy), virology (manipulation of poxviruses would be particularly appreciated, neutralisation assays) or biophysical techniques (viral fusion assays).
• Good interpersonal skills

The application should contain
1. A letter of motivation (1 page) with a short description of your research interests.
2. A CV, including a list of relevant skills, experiences and a full publication list.
3. Names and e-mail addresses of 2-3 reference persons, indicating their professional relation to you.

The starting date is negotiable. Ideally around March 2023, no later than September.

Informal inquiries and application should be sent to Pablo Guardado-Calvo (guardado@pasteur.fr


[Post Date: December 8, 2022]


Research Scientist in Biophysics and Structural Biology

job posting image

Description:

Onxeo is looking for a highly motivated and curious candidate ready to explore and apply technologies dedicated to the characterization of biomolecular interactions.

Under the responsibility of the “Drug Design and lead Optimization” team leader at Onxeo, the role of the candidate will be to conduct biophysical interaction projects using state-of-the-art instrumentations, including, SPR, switchSENSE and DSF technologies as well as structural studies of proteins in complex with therapeutic molecules using X-ray crystallography and/or CryoEM.

The postdoc position is part of a collaboration between Onxeo, a clinical-stage biotechnology company designing and developing novel oncology drugs targeting tumor Damage Response (DDR) and a structural biology research laboratory. 

This is a tremendous opportunity for an individual to contribute to projects of real medical impact.

Missions

Being fully part of Onxeo but mainly at the external research laboratory to perform the experiment, the candidate will be responsible for development and realization of biophysical projects.

  • Contribute to screening projects, from assay development to screening campaign: define, execute experimental processes and data analysis.
  • Contribute to structural studies from sample preparation to structure determination
  • Plan, design and analyze experiments, ensure project delivery (written reports, PowerPoint presentations, data management…)
  • Share scientific knowledge and results with the Group Leaders, Team leader and operational.
  • Monitor scientific and technical development in the field of the activity.

Quality

  • Innovative mindset and adaptability
  • Excellent collaborative skills, demonstrate strong analytical and organizational skills, and work effectively under deadlines.
  • Excellent communication skills and the ability to report and present data to colleagues and senior management.

Role And Responsibilities

  • Be an integral member of drug discovery teams.
  • Ensure the bridge between the 2 institutions Onxeo and the research laboratory.
  • Prepare and execute screening and structural studies according to the need of the research project of the company.
  • Responsible for biophysical result analysis and interpretation.
  • Responsible for the quality and reliability of scientific result.
  • Contribute to the lab life (device maintenance, consumable ordering, labs organization…)
  • Publications are possible but it is not the priority of the company.

Training And Experience

  • PhD in structural biology, biophysics or similar fields with no prior postdoctoral experience needed.
  • Good knowledge in molecular interaction, especially in SPR activities would be an advantage.
  • Ability to work independently in a fast-paced environment and quickly adapt to changes in strategy or work processes.
  • Effective verbal and written communication skills. Fluent in English. Fluency in French would be a plus.
  • Excellent interpersonal skills and able to work in a multicultural, multidisciplinary and business-oriented environment.

Contacts: n.babault@onxeo.com ; jb.charbonnier@i2bc.paris-saclay.fr


[Post Date: December 8, 2022]


Research Associate II - Structural Biology

View the Job Posting Here

job posting image

Description:

Job Description

The Broad Institute of MIT & Harvard is an amazing place - we exist to apply our deep knowledge of human genetics to empower a revolution in biomedicine and accelerate the pace at which the world conquers disease. The Broad Institute’s Center for the Development of Therapeutics (CDoT) and its team of professional “drug hunters” partner with faculty at MIT, Harvard, and the Harvard teaching hospitals to translate emerging biological insights into novel therapeutic strategies. We couple novel technologies and approaches to industry-standard drug discovery rigor to tackle some of the most challenging targets across a wide range of disease areas (including oncology, cardiovascular disease and diabetes, psychiatric disease, infectious disease).

We are currently seeking a highly motivated and passionate research associate to support drug discovery projects. We will provide cutting-edge structural biology professional training to support the candidate in driving therapeutic discovery at the bench through the characterization and crystallization of therapeutic protein targets. The successful candidate will have a solid understanding of protein biochemistry and molecular biology. Experience in structural biology is advantageous.

CHARACTERISTIC DUTIES

  • With training, produce high quality protein crystal structures and co-crystal structures, carrying out the process from crystallization screening through to structure refinement

  • Supporting the crystallographic pipeline through protein design, expression, purification, and biophysical characterization

  • With training, handle CryoEM grids preparation to support MicroED experiment

  • Documenting work, managing, analyzing and effectively presenting results to multi-disciplinary project teams

  • Working in partnership with team members and collaborators to best achieve results

QUALIFICATIONS

  • B.S. in Biochemistry, Biophysics or a related life science field with 0-2 years research experience in an academic or industrial setting

  • Experience with molecular cloning and vector construction, bacterial expression, and protein purification through conventional and affinity-based chromatographic approaches is desired

  • Experience in the functional characterization of recombinant proteins and biophysical characterization of protein-protein and/or protein-small molecule interactions is desired

  • Knowledge in protein crystallography, cryo-EM, or NMR is advantageous

  • A proven record of successful communication and interaction with project team members, external customers or vendors is advantageous

The successful candidate will be a results-focused, team-oriented scientist able to excel in a fast-track environment across multiple projects. They must be accountable, self-motivated, detail-oriented and exhibit problem solving skills. In addition, the successful candidate will be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with team members.

WORKING CONDITIONS

  • Normal laboratory conditions

  • Normal office conditions

Why do your research at Broad:

  • You can make a difference in biomedicine -- Whether you study the biological basis of cancer or look for the genetic code behind debilitating psychiatric disease, you are laying the groundwork for future therapies that will change lives.

  • You will gain invaluable experience -- You will work closely with a wide network of physicians and scientists. Broad uses state-of-the-art technology and empowers ambitious research efforts - it is truly an experience that is unparalleled by any other biomedical research institution. If you choose to pursue a graduate or medical degree, you will be well prepared for the next stage of your career.

  • You will be supported in your efforts to learn and grow -- Every week there are talks open to the Broad community on a variety of scientific topics, often hinging on results that have not yet been published. Many current RAs rave about the mentorship they have received from other Broadies and the variety of social events that allow them to positively enrich their professional network.

Broad culture:

We pride ourselves on being creative and forward-thinking not only in the way we approach our science but also in the way we support our people.

Check out a sampling of our benefits:

  • 3 weeks vacation within the first year, 13 paid holidays plus an annual winter closing from Christmas to New Year’s

  • Commuter passes subsidized at 50%

  • Tuition reimbursement up to $5,250 per calendar year

  • Free FitBit

  • Fooda, on-site lunch available for purchase from local vendors every day

  • LeanBox, vending machine of fresh, healthy snacks available at subsidized prices

  • Free on-site yoga, meditation and boot camp

  • Discounts on entertainment, goods, and services through Working Advantage

  • Regular seminars and discussion groups hosted by our BroadLife office to help you deal with a diverse array of work-life issues and make it easier to integrate work, personal and family commitments


[Post Date: December 8, 2022]


Research Associate

View the Job Posting Here

job posting image

Description:

Job reference: SAE-020555

Location: Oxford Road, Manchester

Closing date (DD/MM/YYYY): 02/12/2022

Salary: £34,308 - £42,155 per annum depending on experience

Employment type: Fixed Term

Faculty/Organisation: Science and Engineering

Division: Department of Chemistry

Hours per week: Full time

Contract Duration: 36 months

School / Directorate: School of Natural Sciences

A three-year post-doctoral position funded by a BBSRC IPA grant is available to study the biochemistry, structure and biotechnological application of the prFMN dependent enzyme phenol phosphate carboxylase (PPC).  The research is carried out in the Manchester Institute for Biotechnology (MIB).  The goal of the project is to understand how this prFMN-dependent enzyme achieves irreversible carboxylation, using structural biology, kinetic and computational approaches. In recent years, the Leys group has been at the forefront of the discovery and fundamental understanding of these ubiquitous bacterial enzymes. Recent advances in the evolution and application of these enzymes have been made by the group, leading to a comprehensive insight into the (de)carboxylases. Our focus is now on those prFMN enzymes that function as obligate carboxylases as well as the development of novel prFMN-dependent systems. ​​​​​​​

Overall, Purpose of the Job

The post-doctoral fellow will study the prFMN dependent PPC that function as carboxylases under physiological conditions, with the ultimate aim to capture CO2 as a building block.  The fellow will take advantage of a wealth of preliminary data already gathered on these systems by our group, enabling them to make rapid progress with validating our present hypothesis. The fellow will take part in preparing the manuscripts describing these results for publication and will work collaboratively with the wider biocatalysts groups at the MIB.

As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status.  All appointments are made on merit.

Our University is positive about flexible working – you can find out more here

Blended working arrangements may be considered

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.

Enquiries about the vacancy, shortlisting and interviews:

Name: Professor David Leys

Email: David.leys@manchester.ac.uk

General enquiries:

Email: People.recruitment@manchester.ac.uk

Technical support:

https://jobseekersupport.jobtrain.co.uk/support/home

This vacancy will close for applications at midnight on the closing date.

Please see the link below for the Further Particulars document which contains the person specification criteria.


[Post Date: November 22, 2022]


Postdoctoral Fellows in Structural Biology

View the Job Posting Here

job posting image

Description:

Date Posted: 23/09/2022
Faculty/Division: Temerty Faculty of Medicine
Department: Structural Genomics Consortium
Campus: St. George (Downtown Toronto)
Supervisor: Dr. Levon Halabelian

About us:
Home to over 40 departments and institutes, the University of Toronto's Temerty Faculty of Medicine lies at the heart of the Toronto Academic Health Science Network and is a global leader in ground-breaking research and education, spanning clinical medicine, basic science, and the rehabilitation sciences sectors.

OVERVIEW:
The Structural Genomics Consortium (SGC) is an international Public-Private-Partnership that supports the discovery of new medicines through open access research (www.thesgc.org). Led from Toronto, the SGC is supported by public and philanthropic funding agencies and ten pharmaceutical industry partners. The SGC-Toronto Laboratory within the Temerty Faculty of Medicine, University of Toronto is offering several Postdoctoral positions (limited term) to join SGC’s structural biology team to investigate the structure, mechanism and druggability of several disease-related human proteins using X-ray crystallography, biochemistry and biophysics. We seek to develop chemical biology tools to elucidate the structure, function and therapeutic potential of select members of human proteins including Methyltransferases, Helicases, DNA and RNA nucleases, E3-ligases and deubiquitinases, among several others. This multidisciplinary project is in collaboration with academic labs as well as pharmaceutical companies. The successful candidate will have a broad knowledge of protein biochemistry and X-ray crystallography, a passion for scientific research as applied to drug discovery and be eager to work as a team player in a fast-paced multidisciplinary environment.
 

QUALIFICATIONS:

  • Ph.D. in biochemistry, molecular biology, structural biology, or related field, with at least one first-authored publication in an internationally recognized peer-reviewed journal. 
  • Strong experience with recombinant protein expression and purification is required. 
  • Experience in X-ray crystallography and/or cryo-EM is highly desirable.
  • Experience within vitro biophysical methods for protein-protein and protein-ligand interaction studies (e.g. DSF, SPR, FP, FRET, ITC) is an asset. 
  • Strong communication skills, particularly the visual presentation of structural data. 
  • Ability to work in a team, communicate and give/receive constructive feedback.
  • High attention to detail, excellent organizational and documentation skills.
  • Experience in preparing manuscripts for submission to peer review publications/journals and presenting findings at meetings and conferences. 

APPLICATIONS SHOULD BE SENT TO: [hrsgctoronto@thesgc.org] with the subject line “SGC Postdoc in Structural Biology”

The University of Toronto and its affiliated hospital research institutes comprise one of the largest and most productive centers of biomedical research in North America. Located in vibrant downtown Toronto, the University provides an outstanding opportunity for scientific research, and career development.

Diversity Statement
The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ2S+ persons, and others who may contribute to the further diversification of ideas.

Accessibility Statement
The University strives to be an equitable and inclusive community, and proactively seeks to increase diversity among its community members. Our values regarding equity and diversity are linked with our unwavering commitment to excellence in the pursuit of our academic mission.
The University is committed to the principles of the Accessibility for Ontarians with Disabilities Act (AODA). As such, we strive to make our recruitment, assessment and selection processes as accessible as possible and provide accommodations as required for applicants with disabilities.

If you require any accommodations at any point during the application and hiring process, please contact us at hrsgctoronto@thesgc.org

Closing Date: 
Friday 31st March 2023


[Post Date: November 14, 2022]


Postdoc Structureal Biology of Parasite Motility

View the Job Posting Here

job posting image

Description:

We are looking for a post-doctoral fellow for a 2.5-year project (possible extension for up to 1 year) in my group at the Faculty of Biochemistry and Molecular Medicine (FBMM), University of Oulu, Finland. Alternatively, an exceptionally highly-qualified PhD student could be considered. The overall aim of my group is to understand the molecular mechanism of malaria parasite gliding motility. To reach this goal, we use a wide variety of structural biology and biochemical/biophysical methods. Our ongoing work is focused on (i) the polymerization and ATPase mechanism of actin, (ii) parasite actomyosin complexes, (iii) the structure and function of the glideosome-associated linker protein, and (iv) reconstructing the entire membrane-delimited motor complex in vitro for structural and functional studies. The exact project will be agreed upon based on the experience and interests of the successful candidate.

The candidate should have a PhD (or MSc if applying for a graduate student position) in a relevant field of science and have experience, or at least a keen interest, in all or several of the following:

- molecular biology and protein expression and purification

- biophysical and biochemical characterization of proteins and their complexes

- protein crystallography and/or cryo-EM

- light and/or electron microscopy

We welcome applications particularly from candidates willing and eligible to apply for competitive funding from national, European, and international sources.

Our research group is split between the FBMM in Oulu and the Department of Biomedicine, University of Bergen, Norway. Our laboratories and the available core facilities available have state-of-the-art equipment for molecular biology, protein biochemistry/biophysics, and electron and light microscopy. We have active collaborations for cryo-EM and cell biology/parasitology.

The project is funded by the Sigrid Jusélius foundation, and the candidate will receive a personal stipend (tax-exempt up to the limit defined by the Finnish tax authorities and subject to a compulsory pension insurance).

Informal inquiries and applications including a motivation letter, a CV with publication list, and contact information for 2-3 referees are to be sent to inari.kursula@oulu.fi. Applications will be considered until a suitable candidate has been identified. The starting date is as soon as possible.

Publications most relevant for the project:

Pires I, Hung YF, Bergmann U, Molloy JE & Kursula I (2022) Analysis of Plasmodium falciparum myosin B ATPase activity and structure in complex with the calmodulin-like domain of its light chain MLC-B. J Biol Chem in press, https://doi.org/10.1016/j.jbc.2022.102634

Vahokoski J, Calder L, Lopez AJ, Molloy JE, Kursula I & Rosenthal PB (2022) High-resolution structures of malaria parasite actomyosin and actin filaments. PLoS Pathog 18: e1010408.

Kumpula EP, Lopez AJ, Tajedin L, Han H & Kursula I (2020) Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and fragmentation. PLoS Biol 17: e3000315.

Kumpula EP, Pires IP, Lasiwa D, Piirainen H, Bergmann U, Vahokoski J & Kursula I (2017) Apicomplexan actin polymerization depends on nucleation. Sci Rep 7: 12137.

Pospich S, Kumpula EP, von der Ecken J, Vahokoski J, Kursula I & Raunser S (2017) Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability. Proc Natl Acad Sci USA 114: 10636-10641.

Jacot D, Tosetti N, Pires IP, Stock J, Graindorge A, Hung YF, Han H, Tewari R, Kursula I & Soldati-Favre D (2016) An apicomplexan actin-binding protein serves as a connector and lipid sensor to coordinate motility and invasion. Cell Host Microbe 20: 731-743.

More info:

Group webpages in Ouluhttps://www.oulu.fi/en/research-groups/molecular-mechanisms-parasite-motility and Bergenhttps://www.uib.no/en/rg/inari

Selected publicationshttps://www.uib.no/en/rg/inari/149298/our-publications

FBMM Ouluhttps://www.oulu.fi/en/university/faculties-and-units/faculty-biochemistry-and-molecular-medicine


[Post Date: October 26, 2022]