Banner Image

Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Group Leader Opening at the Novo Nordisk Foundation Center for Protein Research

View the Job Posting Here

job posting image

Description:

Junior Group Leader Opening at the Novo Nordisk Foundation Center for Protein Research

The Novo Nordisk Foundation Center for Protein Research (CPR) is committed to attract and nurture the development of young talented independent investigators in our unique environment. With this call we wish to recruit a Group Leader to become part of our Protein Structure and Function Program.

The Novo Nordisk Foundation Center for Protein Research

The Novo Nordisk Foundation Center for Protein Research (https://www.cpr.ku.dk) was established in 2007 at the Faculty of Health and Medical Sciences, University of Copenhagen, to promote basic and applied research. Copenhagen is a family friendly but at the same time lively city flooded with cultural events during the year, which is ranked among the best cites to live in the world.

CPR spans broad areas of protein research, ranging from structural and mechanistic understanding of protein complexes and protein pathways. The Center is structured into five complementary research programs: Proteomics, Protein Structure and Function, Protein Signaling, Disease Systems Biology and Protein Memory (starting in 2020), each of which is supported by dedicated technology platforms.

Protein Structure and Function Program

The Protein Structure and Function Program is a founding member of the Integrative Structural Biology Cluster (ISBUC) at the University of Copenhagen (https://isbuc.ku.dk/), and it currently consists of two research groups led by Professor Guillermo Montoya and Associate Professor Nicholas Taylor. The program also coordinates the Center´s protein production, molecular biophysics and crystallization platforms and the University of Copenhagen node of the national cryoEM facility (https://krios-denmark.ku.dk/), which is equipped with a Titan Krios and a Glacios, both equipped with Falcon 3EC direct electron detectors. Large computer power is available through our partnership with the Danish Supercomputer for Life Sciences (http://www.computerome.dtu.dk/). In addition, the Copenhagen area provides easy access to the synchrotrons in Hamburg (DESY) and Lund (MAX-IV) as well as the European XFEL (Hamburg).

Job description and responsibilities

We are looking for strong candidates that would develop and lead an independent, innovative research group investigating game changer questions in biology at a molecular level. We seek for applicants in the area of integrative structural biology using and/or combining cryo-electron microscopy (including cryo-electron tomography), crystallography and biophysical approaches towards the mechanistic understanding of cellular processes. The ideal candidate should be complementary to the current interests and analytical expertise in the Protein Structure and Function Program and with a high potential to integrate within the other CPR programs through interdisciplinary projects.


[Post Date: January 16, 2020]


Postdoctoral Position: Biochemistry and Structural Biology of Functional RNA/Protein Complexes

job posting image

Description:

Biochemistry and Structural Biology of Functional RNA/Protein Complexes

UT Southwestern Medical Center

A postdoctoral training position is available in the laboratory of Yunsun Nam, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center to study the mechanisms of RNAs that regulate gene expression. Our laboratory has several exciting projects related to how RNA shape changes the destiny of the RNA by altering its function and specific interactions with proteins. The goal is to determine how macromolecular recognition and enzymatic regulation are accomplished, using biochemistry, structural biology, and molecular biology. The functional noncoding RNAs we study are relevant for normal development as well as diseases such as cancer, making our mechanistic work also valuable for therapeutics research. Postdoctoral scholars will have many opportunities to learn the newest methods in protein and nucleic acid biochemistry and biophysics, in addition to working in an exciting, fast evolving field in biomedical sciences. We use various approaches, including cryo-electron microscopy (cryo-EM), X-ray crystallography, NMR spectroscopy, molecular biology, nucleic acid and protein biochemistry, genomics with next-generation sequencing, drug discovery, and mammalian cell-based studies. Information on the UT Southwestern postdoctoral training program and benefits can be found in the Postdoc Handbook or at www.utsouthwestern.edu/postdocs. For more information, please visit www.ynamlab.org

Candidates must hold a Ph.D. and/or M.D. degree. Experience in biochemistry (protein or nucleic acids), cell biology, genomics, and/or structural biology leading to publication in peer-reviewed journals is recommended. The position is open immediately and available for > 3 years.

Interested individuals should send a pdf file containing CV, statement of interests, and a list of three references to: Yunsun Nam (yunsun.nam@utsouthwestern.edu). 

UT Southwestern Medical Center is an Affirmative Action/Equal Opportunity Employer.


[Post Date: January 15, 2020]


MX beamline data scientist position at SLS

View the Job Posting Here

job posting image

Description:

The planned SLS 2.0 upgrade provides a unique opportunity to further develop three MX beamlines at SLS. To fully utilize the brightness enhancement of SLS 2.0, we will explore data-driven approaches in MX experiments. Therefore, we are searching for a beamline data scientist to join the MX group. You can find more information and submit your application at https://www.psi.ch/en/pa/job-opportunities/32260-beamline-data-scientist.


[Post Date: January 15, 2020]


Postdoc position protein crystallography, Heinrich-Heine-University, Düsseldorf, Germany

job posting image

Description:

The Center for Structural Studies (CSS) is a central scientific research and service facility of the Faculty of Mathematics and Natural Science at the Heinrich-Heine-University Düsseldorf (www.css.hhu.de). The CSS aims for scientific tasks within all areas of structure-supplying methods at an atomic level. The CSS provides all steps as full-service as well as access to our infrastructure and scientific support for the individual experiments of all members of the HHU and external users.

In particular:

  • X-ray diffraction analysis and structure determination (MX) of proteins (in house and at synchrotrons)
  • Small-Angle-X-ray-Scattering-Analysis (SAXS) of proteins and all kinds of complexes thereof (in house and at synchrotrons)
  • Molecular Modelling and Simulation for macro- and micromolecules

In support of the MX unit we offer a postdoc position within a BMBF (Federal Ministry of Education and Research) founded project for an experienced person (100 %, EG 13 TV-L/TVöD-Bund) for 3 years, to be filled as soon as possible.

Your Qualifications

  • degree in Biochemistry, Biology or a related field and a PhD ideally in X-ray protein crystallography
  • ideally several PDB-depositions and related publications
  • good work experience in protein biochemistry, crystallization and X-ray crystallography
  • good knowledge of software packages employed in protein crystallography (esp. XDS, CCP4, coot) is a must
  • good communication skills and like to work in a multi-disciplinary team

Key Responsibilities

  • all types of crystallographic activities, including:
  • planning and performing crystallization experiments
  • collecting X-ray diffraction data (in-house generator and synchrotron beamlines)
  • processing diffraction data, including phasing (mainly MR)
  • refining protein structures following the quality criteria
  • presenting the results

 

According to the applicant’s personal qualification, employment will be based on EG 13 TV-L / EG 13 TVöD-Bund. Qualified candidates should send their complete application (cover letter, curriculum vitae, contact info of two references, certificates) until 15.02.2020 by e-mail (one single pdf-file <5MB) to css@hhu.de.

We are looking forward to your joining of our team!


[Post Date: January 15, 2020]


Postdoctoral Position in Structure and Function of GPCRs at Washington University in St. Louis, Missouri

job posting image

Description:

Postdoctoral Position in Structure and Function of G protein-coupled Opioid Receptors and Other Pain-related Targets.

A postdoctoral position is available in the research group of Tao Che, Department of Anesthesiology, Washington University in St. Louis, Missouri. Employment will commence tentatively in early Summer 2020, exact starting date is negotiable.

The long term goal of the Che lab is to understand the structure, function and pharmacology of pain-related G protein-coupled receptors (GPCRs), particularly opioid receptors. Opioid receptors are GPCRs whose role in pain sensation has made them major drug targets for pain medications such as oxycodone and morphine. However, opioids have exceptionally high abuse potential and often cause fatal side effects such as respiratory arrest and death. Towards a molecular understanding of opioid receptor signaling, we employ a combination of state-of-the-art structural (X-ray crystallography, cryo-EM) and pharmacological techniques to gain an atomic-level understanding of opioid receptor activation (Cell, 2018), and leverage these data using structure-based drug design to develop novel therapeutics (Nature, 2018).

Applicants should hold a PhD in a relevant subject area, such as protein biochemistry, structural biology or pharmacology. Structure determination using x-ray crystallography and/or cryo-EM along with functional analysis using biochemical, biophysical and pharmacological techniques would be a plus. The ability to work in a team, as well as good communication skills, are expected.

Applications that include a brief description of research interests, as well as a CV with contact information of three references should be sent to: taoche@wustl.edu


[Post Date: January 15, 2020]


ZoBio is looking for an experienced scientist to strengthen its Structural Biology / X-ray Crystallography group in Leiden (NL)

job posting image

Description:

ZoBio (www.zobio.com) was founded in 2004 and is located in Leiden, The Netherlands. ZoBio offers innovative research services in the field of small-molecule drug discovery to the pharmaceutical and biotech industries. Our international team of 26 people covers four fields of expertise: Protein Engineering and Production, Assay Development and Screening, Structural Biology, and Medicinal Chemistry.

We are currently looking to strengthen our team with a highly motivated X-ray crystallographer, with a track record in protein crystallography and with experience in model building and refinement of protein – small-molecule complexes.

You will support our clients’ drug discovery programs by solving ligand-protein structures by X-ray crystallography. You will work with minimal supervision but in a highly collaborative environment within the Structural Biology team and will effectively cooperate on a per-project basis with other research groups at ZoBio. This role requires working on multiple projects simultaneously and in a rapidly evolving environment. Team spirit and excellent organization and communication skills are essential.

RESPONSIBILITIES

  • High-throughput crystal preparation and optimization utilizing automation and robotics.
  • Data collection at synchrotron facilities.
  • High-throughput and -quality structure elucidation and interpretation of biological macromolecules in complexes with small molecules of interest.
  • Report results to the group head and prepare presentations on the structural data for the project teams and clients.
  • Maintain up-to-date understanding of the state-of-the-field in X-ray crystallography and in relation to modern drug discovery challenges.

REQUIREMENTS

  • PhD in relevant field with experience in an industrial or collaborative setting.
  • Use of common structure determination software, including the CCP4 suite and Coot.
  • Hands-on experience with ligand modelling into electron density maps, and macromolecular model building and refinement in the context of Structure-Based Drug Discovery campaigns.
  • Hands-on experience in solving challenging X-ray crystallography cases (e.g. ab initio structure solution).
  • Able to work in a team in a result-driven, goal-oriented environment.

It is fully expected that you will become a permanent and integral member of the ZoBio team, after an initial period of 12 months.

A tailored remuneration package will be proposed in line with individual qualifications and experience. The position is immediately available; the evaluation and assessment of candidates will run until the position is filled but not later than the end of February 2020.

Please send your CV, motivation letter and names of potential referees at <info@zobio.com> with the subject: “Scientist position in X-ray Crystallography”.

 


[Post Date: January 15, 2020]


Postdoc Florida State University

job posting image

Description:

One postdoctoral position is available immediately in an enzymology laboratory to elucidate mechanisms of DNA/RNA synthesis, DNA lesion bypass, and base excision repair catalyzed by various human and viral DNA/RNA polymerases, and to mechanistically investigate gene editing enzymes including CRISPR/Cas9 and Cas13a. Background in structural biology (X-ray crystallography and/or CryoEM), biophysics, protein purification, and recombinant DNA techniques is preferred. An important criterion for selection will be the ability of the desired individual to pursue independent research in an active multi-disciplinary setting. Interested candidates should send a CV and a statement describing experience, goals, and reasons for the interest in this position, and arrange to have three letters of recommendation sent to Dr. Zucai Suo, Eminent Professor and Dorian and John Blackmon Chair of Biomedical Science, Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL. Dr. Suo can be contacted by email (zucai.suo@med.fsu.edu). Further information about the research projects in the Suo Lab can be obtained from https://med.fsu.edu/index.cfm?page=suolab.research.

Employer: Florida State University College of Medicine

Location: Tallahassee, Florida

Salary: NIH guidelines for post-doctoral salaries + benefits

Discipline: Life Sciences, Biochemistry, Biology, Biophysics, Structural Biology, and Biomedical Sciences Position Type: Full Time Organization Type: Academia Job Type: Postdoc


[Post Date: January 14, 2020]


Senior Crystallography Scientist

View the Job Posting Here

job posting image

Description:

Evotec (UK) Ltd is currently seeking to add to our Structural Biology Department.  The group works closely with our Discovery Chemistry Department and with clients to develop novel small molecule drugs.  The group is at the forefront of new science and technology, and is seeking to expand as business needs grow.


[Post Date: January 14, 2020]


Postdoctoral Research Fellow at Merck (Boston MA)

View the Job Posting Here

job posting image

Description:

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

What You'll Be Doing:

The aim of the research is to better understand interactions driving PXR binding and mitigate the liability of PXR-active compounds by utilizing a structure-guided drug design approach.  More specifically, the research will involve:

  • Identification of compounds, via mining of internal data, for which small chemical structure changes result in large differences in functional PXR activation 
  • Improved characterization of the energetics underlying compound binding to PXR using biophysics techniques (e.g. ITC) with an aim to correlate measured thermodynamic parameters with functional activation and structural determinants of the identified compounds
  • Evaluation of PXR conformational flexibility and how it is affected upon compound binding through NMR and room-temperature crystallography
  • Development of an improved PXR protein construct for cocrystallization of PXR activators to provide information suitable for SBDD

Responsibilities include but are not limited to:

  • Structure/function analysis of PXR ligand binding domain with compounds demonstrated to bind and activate the receptor using existing and newly-generated structures and activity measurements
  • Collaboration with coworkers with cheminformatics, biophysical, protein expression/purification, and macromolecular structural expertise
  • Participation in scientific group meetings and other presentation opportunities, both internal and external

What You Bring:  

  • Candidates must currently hold a PhD OR receive a PhD by fall. 
  • Documented experience with at least two of the following techniques:
  • Macromolecular crystallography
  • Biomolecular NMR spectroscopy
  • Biophysical binding assessment using isothermal titration calorimetry
  • Recombinant protein expression and purification from bacterial culture
  • Primary author on at least one peer-reviewed publication in the last three years

Preferred Experience and Skills:

  • Excellent oral and written communication skills
  • Ability to work collaboratively
  • Macromolecular crystallography
  • Biomolecular NMR spectroscopy
  • Biophysical binding assessment techniques (e.g. ITC, SPR, FP, TSA)
  • Recombinant protein expression and purification from bacterial culture
  • Comfort working in a Linux-based computing environment
  • An open mind and a willingness to learn

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

If you need an accommodation for the application process please email us at staffingaadar@merck.com
For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster
EEOC GINA Supplement​
OFCCP EEO Supplement

OFCCP Pay Transparency Rule
We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully 
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status: Regular

Relocation: Domestic/International

VISA Sponsorship: Yes

Requisition ID:R28296


[Post Date: January 14, 2020]


Open scientist position at the EMBL-Grenoble - Project leader for ID30A/MASSIF-1 beamline upgrade

View the Job Posting Here

job posting image

Description:

We have an open scientist position at the EMBL-Grenoble for a Project leader to oversee our contribution to the upgrade of the fully automated ID30A/MASSIF-1 macromolecular crystallography beamline at the ESRF. This is an exciting opportunity for an ambitous individual to join a team of scientists and engineers from the EMBL and ESRF in developing fully automated data collection protocols to maximise the scientidic potential of the ESRF Extremely Brilliant Source upgrade.

Closing date: Feb. 7th 2020.

Interview date: March 6th, 2020


[Post Date: January 14, 2020]


Postdoc position: Computational Algorithms combining Crystallography and WAXS for Drug Discovery

View the Job Posting Here

job posting image

Description:

post-doctoral position is available immediately in the Grant Lab in the Department of Structural Biology at the University at Buffalo in Buffalo, NY, USA.

Our group is currently seeking postdoctoral candidates to develop novel computational algorithms combining crystallography and solution scattering to aid in drug discovery

The successful completion of the project will impact many fields from drug discovery and development to basic biological processes. An excellent opportunity for creative, out-of-the-box thinkers who are self-motivated. Candidates will have the opportunity and support to present their research findings at national and international conferences and in high-impact scientific journals. The positions are for an initial term of two years with possibilities for renewal based on performance and available funding. Compensation will be commensurate with experience.

Minimum Qualifications
A PhD degree in structural or computational biology, chemistry, physics, mathematics, computer science or related fields.

Preferred Qualifications
Proficiency in computer programming, in particular Python. Excellent oral and written communication skills for presenting research at conferences and in scholarly journals. Background in physics or mathematics is a plus, in particular familiarity with concepts of Fourier transforms and diffraction. Experience with structural biology techniques such as crystallography and solution X-ray scattering is a plus.

Apply
Interested candidates can apply on the UBJobs website here: https://www.ubjobs.buffalo.edu/postings/21288


[Post Date: January 14, 2020]


Postdoctoral position in time-resolved optical spectroscopy/crystallography at the ESRF

job posting image

Description:

The European Synchrotron ESRF in Grenoble, France, will resume its activities this year after a complete machine upgrade, which will bring exciting new possibilities of experiments, in particular in time-resolved serial synchrotron crystallography (SSX). The Structural Biology Group is currently building a beamline dedicated to SSX planned to perform time-resolved experiments with a microsecond time resolution. In order to prepare these experiments, we are developing an offline setup to perform microsecond time-resolved UV-vis absorption spectroscopy experiments on protein crystals. This time-resolved setup is part of the in crystallo optical spectroscopy (icOS) Lab, (formerly known as the Cryobench , http://www.esrf.eu/home/UsersAndScience/Experiments/MX/icOS.html ), which provides various optical spectroscopic techniques (UV-vis absorption, fluorescence, Raman) that can be applied to proteins in the crystalline or solution state, before, during, or after an X-Ray diffraction experiment. We are looking for a postdoc interested in contributing to the development of the TR-icOS setup and to associated scientific projects coupling time-resolved optical spectroscopy and X-ray crystallography. The successful candidate should have strong expertise in at least one of the following topics: optical spectroscopy, instrumentation, X-ray crystallography.

For further information, please email Antoine Royant, responsible of the icOS Lab (antoine.royant@esrf.fr) or Daniele de Sanctis, responsible of the SSX beamline ID29 (daniele.de_sanctis@esrf.fr).


[Post Date: January 14, 2020]


Postdoctoral Fellowship (2 years) to study membrane protein transport at Umeå University, Sweden

job posting image

Description:

The Andersson lab at the department of Chemistry at Umeå University, Sweden, is looking to recruit a postdoctoral fellow (2-year fellowship, funded by the Kempe foundation) to study membrane protein transport. The Andersson lab combines time-resolved X-ray solution scattering and computer simulations to determine membrane protein dynamics and transport in the lipid environment. The overall goals are to determine structures and timing of transient protein states in the membrane.

The research spans molecular biology production, nanodisc insertion, and characterization of proteins to development work at synchrotrons MAX IV (Lund) and ESRF (Grenoble). The project can also involve computer simulation – the extent to which will depend upon the background/interest of the Fellow. The work will be performed within the context of Integrated Structural Biology (https://www.biostruct.umu.se) at Umeå University that provides seminar series as well as an exciting research environment.

Qualifications

The required qualification is a doctoral degree in chemistry, biophysics, biochemistry, physics, or a foreign degree that is deemed equivalent. The applicant must have practical experience and expertise from protein production and characterization. Prior experience from working with membrane proteins, nanodisc insertion, structural biology, and computer simulations are considered merits. Good knowledge of the English language, both written and spoken, is required. A suitable candidate should also be creative, have good collaboration skills, a high degree of independence and problem-solving analytical ability.

 Application

The application should include:

  •  A cover letter stating why you want to join the lab and study membrane protein transport & dynamics (maximum 1 pages). This letter must also contain your contact details.  
  •  A Curriculum Vitae including a list of peer-reviewed published articles
  •  Copies of doctoral degree certificate and other relevant degree certificates
  •  Name and contact information for two reference persons of which one should be your PhD supervisor

Send your complete application to: magnus.p.andersson@umu.se

Webpage: https://www.biostruct.umu.se/principal-investigators/magnus-andersson/


[Post Date: January 14, 2020]


Scientist 1 (Protein Sciences) - Chan Zuckerberg Biohub

View the Job Posting Here

job posting image

Description:

Description

The Chan Zuckerberg Biohub is a well-funded, non-profit, life science research institute that brings together three powerhouse universities – Stanford, UC Berkeley and UC San Francisco – into a single collaborative technology and discovery engine. We are committed to solving some of the world’s biggest problems together: we seek to help cure, prevent or manage all human diseases by the end of the century. We find and invest in the best and brightest scientists and engineers and we seek to create an environment of true and free-flowing collaboration. We provide the best technologies and tools available – and when they don’t exist yet, we build them.

We are seeking an outstanding protein biochemist to join our Protein Sciences group within the Infectious Diseases Initiative at the Chan Zuckerberg Biohub. The candidate will be responsible for the development of novel methods and/or technologies that aim to design, purify and/or characterize antigens and antigen-immune molecule complexes of interest. In their role as a respected protein sciences expert at the Biohub, the candidate will also foster collaborations within the broader UCSF, UC Berkeley and Stanford communities by working closely with research associates, students and/or postdoctoral associates from all three institutes.

RESPONSIBILITIES

  • Develop and execute on a novel project in the area of antigen-immune molecule complex design, purification and/or characterization, including epitope mapping
  • Build up working collaborations with researchers at partner institutes (UCSF, UC Berkeley and Stanford) as needed, to further the objectives of the primary research project
  • Perform necessary wet lab experiments individually, or with support from Protein Sciences group members as needed.

Requirements

  • PhD (or equivalent experience) in Biochemistry, Molecular Genetics, Immunology, Structural Biology, or related discipline
  • Expertise in the purification and characterization of challenging macromolecules and/or complexes (e.g. viral glycoproteins, antibody-antigen complexes)
  • Experience with automation (e.g. liquid handlers) and higher throughput methodologies for protein purification and/or characterization
  • Some familiarity with experimental structural biology methods, such as hydrogen-deuterium exchange (HDX) or cryo-EM, is a plus

This opportunity is full-time only. No contractors, consultancies or recruiters will be considered. CZ Biohub is proud to be an equal opportunity employer.


[Post Date: January 14, 2020]


Positions available at Evotec

job posting image

Description:

There are two positions currently open to join us at Evotec Princeton within our rapidly expanding Reagents Team.

If you’re interested, please use the links below to apply for the positions through Workday:

  • Senior Scientist - Protein Purification (Princeton)

https://evotecgroup.wd3.myworkdayjobs.com/en-US/Evotec_Career_Site/job/Princeton/Senior-Scientist---Protein-Purification_REQ-01105

  • Research Associate - Protein Purification (Princeton)

https://evotecgroup.wd3.myworkdayjobs.com/en-US/Evotec_Career_Site/job/Princeton/Research-Associate_REQ-01232


[Post Date: January 9, 2020]


Postdoctoral position in Structure Function studies on Transport Proteins

job posting image

Description:

A postdoctoral position is available in the Valiyaveetil group at Oregon Health and Science University in Portland, Oregon. The Valiyaveetil group investigates structure and function of ion channels and transporters using a combination of unnatural amino acid mutagenesis, electrophysiology, structural biology and spectroscopy. See references [ELife (2018), 7, doi:10.7554/eLife.36478; Nat Commun. (2018), 9, 5055; PNAS (2019) 116, 15939-15946] for examples of recent research from the lab. The group is a part of the Program in Chemical Biology in the Department of Chemical Physiology and Biochemistry.

The position is suitable for a highly motivated candidate with a recent (less than 1 year) Ph.D. in Biochemistry, Biophysics or a related discipline. The candidate will investigate glutamate transporters (and related transporters) using a combination of biochemical, spectroscopic and structural approaches. The candidate for this position should have prior experience in membrane protein biochemistry. Expertise in structure determination using crystallography or cryo-EM or in spectroscopic approaches such as fluorescence or EPR will be a plus. The position provides the candidate with a unique opportunity to enhance their skill set with the techniques for membrane protein engineering using unnatural amino acid mutagenesis.

The Valiyaveetil lab is well equipped to carry out structural and functional studies of ion channels and transporters. OHSU provides an excellent scientific environment. Portland is consistently rated as one of the most livable cities in the US.

To apply send CV, a 1-2 page description of graduate research and future research plans along with contact information for three references by email to: valiyave@ohsu.edu

OHSU is an equal opportunity, affirmative action institution.


[Post Date: January 9, 2020]


Research Scientist/Engineer Assistant – Crystallography

View the Job Posting Here

job posting image

Description:

The UW Institute for Protein Design currently has an outstanding opportunity for a Research Scientist Assistant to support peptide and protein crystallography efforts for the IPD’s Structural Biology Core (SBC).  This person will be assigned work under general guidance and receive instruction on specific assignment objectives, complex features, and possible solutions. Guidance on unusual problems will be provided by IPD Faculty, other UW Faculty, or other experts in biophysical characterization and work shall be reviewed for application of sound professional judgment.

The Research Scientist Assistant – SBC will interface directly with members of other IPD Core Laboratories as well as graduate students and postdoctoral fellows in IPD Faculty Laboratories. Research activities will involve setup of crystallization trays, screening for crystal formation and growth using microscopy, operation of X-ray generation sources, and eventually training in data collection and solving structures.  The RSA SBC will grow to be an expert in protein and peptide x-ray crystallography and will therefore be of assistance in optimization of crystallization conditions and support of crystallography needs for the IPD. With the gaining of expertise, high throughput robotics, maintenance and operation of x ray sources and independent operation in crystallography projects.

In this role, ~40% of the effort will be dedicated to the setup and monitoring of crystallography trays.

Another ~20% of effort will be dedicated to maintenance and operation of liquid handling robotics.

The remaining ~40% of effort will, eventually, be dedicated to the maintenance and operation of x-ray generating sources for x-ray diffraction of peptides and proteins. 

Minimum Requirements:

  • Bachelors’s Degree in Biochemistry, Biology or similar + less than 3 months of experience in related field.
  • The Research Scientist Assistant-SBC is devoted primarily to scientific research and requires a B. Sc. in a biology-related field,  with less than 3 months of experience in characterization of protein. Candidates must be capable of applying standardized scientific procedures and techniques to assignments of limited complexity, involving potentially conflicting design requirements.

Desired:
An ideal Research Scientist Assistant – SBC candidate will be someone who (i) has had experience in a laboratory setting during the undergraduate degree obtention, (ii) will use their knowledge gained in their undergraduate degree program to apply fundamental concepts, practices and procedures, (iii) follows procedures for small projects and/or major project tasks which may last years under immediate supervision, and effectively manages them under guidance and direction from project staff; interfaces with investigator peers, (iv) can provide timely and professional scientific services to a number of internal collaborators on approximately 2-3 different projects, (v) can perform tasks and methods as directed, (vi) and enjoys interacting with other scientists in a highly collaborative and fast-paced work environment.


[Post Date: January 8, 2020]


Postdoc Univeristy of California Irvine

job posting image

Description:

The Goulding lab in the Department of Molecular Biology and Biochemistry at the University of California at Irvine seeks to recruit an outstanding postdoctoral scientist with experience and interest in structural biology and biochemistry of protein complexes. The Goulding lab focuses on iron uptake in Mycobacterium tuberculosis. This position provides the opportunity for broad training in structural biology, metalloprotein biochemistry, kinetics, spectroscopy, and microbiology.

The University of California at Irvine campus is located on the beautiful Southern Californian coast-line approximately five miles from vibrant Newport Beach and Crystal Cove.   It is also approximately 40 miles from both Los Angeles and San Diego. The surrounding areas offer affordable rental housing with a short walk/ride to campus, the beach and nightlife.

Candidates must have their Ph.D. by the beginning date of the appointment in Biological Chemistry or a related discipline (Chemistry, Biochemistry, Molecular Biology and Biophysics, Microbiology, Pharmaceutical Sciences, Biochemical, and Biomedical engineering). The successful candidate will have strong experience in molecular biology, protein expression, purification, crystallization, and functional analysis. Training in X-ray crystallographer is desirable. Opportunities will exist for involvement in specific projects and co-authorship of manuscripts, and requires a two-year commitment.

The salary will follow NIH guidelines for post-doctoral fellows and depends on previous experience.

To apply, please send curriculum vitae and the names of three references to: celia.goulding@uci.edu. Review of applications will begin immediately and will continue until the position is filled.

 


[Post Date: January 8, 2020]


Senior Research Technician in Protein Purification

View the Job Posting Here

job posting image

Description:

Are you an experienced technician looking for a challenge?  Do you have a background in molecular/cell biology or biochemistry?  Do you want to further your career in one of the UK’s leading research intensive Universities?

We are looking for a highly motivated person to provide technical support to the Membrane Protein Biology group of Professor Adrian Goldman. The project is highly multidisciplinary involving molecular biology, protein expression using eukaryotic expression systems, protein biochemistry and protein-protein interaction studies. The project is funded by the BBSRC.

The successful candidate will have a degree in a related subject (or equivalent experience) and have significant experience of working in a similar technical role. Experience in DNA cloning techniques, recombinant protein production and purification of membrane proteins for structural biology and biophysical studies are essential. The lab uses a range of techniques, including recombinant protein production in insect cells and E. coli, cryo-electron microscopy, X-ray crystallography, high-throughput (HT) screening, enzymology and protein-protein binding studies. In your role as laboratory technician you will work closely with other research scientists within the group. You should, therefore, be highly motivated, organised, and able to communicate and collaborate as part of a team.


[Post Date: January 7, 2020]


Postdoctoral position available in the area of Membrane Transport at Northwestern University

View the Job Posting Here

job posting image

Description:

The laboratory is seeking a highly motivated individual for a postdoctoral fellow position in the field of protein structural biology. The individual will join a  research team studying the structure and function of ABC transporters.  Our laboratory is equipped with state-of-the art facilities for x-ray crystallography, cryo-EM and protein biochemistry research.  We are approximately an hour drive to Argonne National labs (APS).

An ideal applicant would be highly motivated with strong analytical skills and enjoy working independently as well as in a collaborative environment. A strong background in structural biology, protein expression and biochemistry is a plus.  The position requires a Ph.D. in a related field and less than one year of postdoctoral experience.

Applicants should email their CV and a summary of their research experience to Dr. Heather Pinkett (h-pinkett@northwestern.edu).


[Post Date: January 7, 2020]


Postdoc position, Department of Biochemistry, University of Oxford

View the Job Posting Here

job posting image

Description:

Postdoctoral Research Associate in Ubiquitin Signalling

We are seeking to appoint a Postdoctoral Research Associate with experience of structural biology techniques to join the group of Dr Paul Elliott to investigate the mechanisms of ubiquitin signalling within inflammation. The Elliott group is a newly established laboratory within the Department of Biochemistry at the University of Oxford and is at the forefront of ubiquitin signalling in inflammation. The post-holder will have access to state of the art facilities located within the thriving Department and will employ a structural biology approach to address the group's research questions.

Applicants should hold a PhD/DPhil, or be near completion of a PhD/DPhil in structural biology, biochemistry or related area and have gained experience in a wide range of structural biology experimental techniques. You will be highly motivated with a proven ability to independently and effectively manage research projects and work within a team. Additionally, you will have excellent written communication skills and have demonstrated your ability to produce high quality research through publication in peer-reviewed journals.

Closing date for applications: 12:00 (midday) GMT on Friday 31st January 2020


[Post Date: January 7, 2020]


Postdoc & Senior Research Technician

View the Job Posting Here

job posting image

Description:

There are two vacancies in my laboratory at the University of Leeds, one for a postdoctoral associate working on integral membrane pyrophosphatases )Vidilaseris et al., Sci Adv 5, eaav7574 (2019), Li et al., Nat Commun 7, 13596 (2016), Kellosalo et al., Science 337, 473-76 (2012).).  And the other for a senior research technician supporting this and other membrane protein projects in the laboratory.  I can not find the vacancy code at the university website at the moment, but if you write to me, I will supply it by return email as soon as I know it.  Both positions are for three years with a start date of February 1st, or as soon as possible.


[Post Date: January 7, 2020]


Postdoctoral Fellow Positions - The Hospital for Sick Children Research Institute (Toronto, Canada)

job posting image

Description:

Job description

Dr. Julien’s laboratory at The Hospital for Sick Children Research Institute (Toronto, Canada) is looking for two Postdoctoral Fellows to join our Structural Biology team. By using a combination of biochemical, biophysical, immunological and structural techniques, the successful candidates will participate in the characterization of 1) immune receptors recognized by therapeutic antibodies, and 2) immune complexes of malaria antigens and human inhibitory antibodies. We are looking for driven and enthusiastic scientists who demonstrate passion and creativity towards the structure/function study of important disease targets and who can thrive in a highly-collaborative setting.

 Roles & Responsibilities

  • Design and optimize constructs for expression in E.coli, insect cells (Sf9) and mammalian cells (HEK 293F);
  • Use Electron microscopy to determine the molecular structures of antigen-antibody complexes;
  • Determine X-ray crystal structures of antigens and antigen-antibody complexes;
  • Perform ITC and BLI binding assays between antigens and purified antibodies to determine binding thermodynamics and kinetics;
  • Perform protein engineering to develop antibody therapeutics and immunogens using structure-based approaches;
  • Biophysically characterize purified antigens for their Tm, Tagg and polydispersity.

Desired Skills and Experience

  • Structural Biologist with a PhD in Biochemistry, Immunology, Molecular Biology, or related field;
  • Expertise in Cryo-electron microscopy and/or X-ray crystallography;
  • Experience in molecular biology, protein expression in various systems, purification and biophysical characterization (Octet, ITC, SEC-MALS, accelerated stability);
  • Strong knowledge in using structural biology to study pathogens and/or immune responses, especially in a context of structure-based antibody and vaccine design;
  • Practical experience in using in silico approaches for protein engineering is a plus;
  • Demonstrated ability to participate in collaborative scientific projects;
  • Organization skills, efficiency and meticulous record keeping.

About Us

Dr. Julien's laboratory is interested in the structure/function study of immune receptors and their interactions with antigens and therapeutics. A better understanding of the structures of B cell surface molecules will serve towards the rational design of improved biologics and vaccine immunogens against a variety of pathogens, including malaria and HIV-1. https://lab.research.sickkids.ca/julien/

We are located in The Peter Gilgan Centre for Research and Learning, a new 21-story, 750,000 square-foot facility that incorporates an open-concept design, state-of-the-art research facilities, and collaborative work spaces. As a member of the SickKids community, you will become part of a world-renowned organization dedicated to fulfilling a vision of Healthier Children, A Better World. For over 135 years, SickKids has worked hard to make the world a better place for children and their families. SickKids researchers have developed Pablum, discovered the gene for cystic fibrosis and are on the leading edge of research in a wide range of disciplines. Each day, people around the organization are doing meaningful work that directly, and often indirectly, benefits children in Canada and around the world.

Please apply before Jan 31 by sending a CV and cover letter to: jean-philippe.julien@sickkids.ca. Anticipated start date in Spring/Summer 2020.


[Post Date: January 2, 2020]


Multiple Postdoctoral Fellowships available at the “Multiscale Research Institute for Complex Systems” at Fudan University of Shanghai

job posting image

Description:

The Multiscale Research Institute for Complex Systems (MRICS) at Fudan University is located at the Zhangjiang Campus of Fudan University and is supported by the Shanghai High-level Talents Program.  MRICS is strongly committed to the development of novel and effective multi-scale imaging technology that spans microscopic molecular structures all the way to macroscopic medical imaging, with the aim to provide unprecedented spatial and temporal insights into the structures and functions of living beings at all levels (molecules, cells, tissues, organs and even whole organisms). Specifically for structural biology, MRICS is equipped with a state-of-the-art cryo-EM facility that includes FEI Titan Krios with Volta phase plate, Glacios, Talos and Aquilos. MRICS is also located next to Shanghai Synchrotron Radiation Facility for X-ray crystallography.

Our team includes Nobel laureate and international leading interdisciplinary experts.   

We have new openings for multiple postdoctoral fellows in structural biology who will mainly study important biological systems by means of cryo-electron microscopy including single-particle and tomography.  

Requirements:

The applicants should have a recent Ph.D. degree (within two years of graduation) or will have a Ph.D. degree within the next six months in biology or chemistry-related fields, be devoted to excellence in scientific research, have strong sense of responsibility, and be highly motivated and hardworking.  For these positions, extensive experience in protein expression and purification is a must, while prior experience in X-ray crystallography or cryo-EM is a plus, but is not required. 

Compensation:

1)    We offer internationally competitive salary, fringe benefits and yearly bonus. The level of salary will be determined according to the applicant's experience and qualification; 

2)    Low-rent housing on campus is provided; 

3)    There are ample opportunities to collaborate with world-renown laboratories;

4)    We provide support for applying for funding opportunities whenever applicable. 

Shanghai is one of the most cosmopolitan cities in China with strong economy and vibrant scientific community.

For interested applicants, please submit postdoctoral application packages (a combined pdf) including resumes, representative publications, phone numbers and email addresses of three academic referees to mrics_fd@fudan.edu.cn.

We look forward to your joining of our first-class team!


[Post Date: January 2, 2020]


Postdoctoral Position at NIH to Study Structures and Mechanisms of Cellular and Viral Noncoding RNAs and RNPs

View the Job Posting Here

job posting image

Description:

A postdoctoral position is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between the accelerated discovery and functional description of the noncoding transcriptome, and the lack of structural and mechanistic understanding of complex noncoding RNAs and RNPs. We seek a new member to join our diverse group to study gene-regulatory riboswitches, highly structured viral RNAs, long noncoding RNAs and their RNP complexes. See https://www-mslmb.niddk.nih.gov/zhang/zhanglab.html for details.

The lab is part of the Earl Stadtman Investigator program for high-risk, high-impact research at the NIH intramural program consisting of 1100 labs. The lab has dedicated access to complete suites of state-of-the-art equipment in structural biology (Mosquito, Dragonfly, Rock Imager, Akta Pures, FSEC, etc., and regular synchrotron access for X-ray crystallography; Titan Krios and Glacios for single-particle Cryo-EM; SAXS, AFM, NMR, etc), cutting-edge biochemistry, biophysics (ITC, DSC, SPR, BLI, AUC, DLS, SEC-MALS, CD, fluorescence, thermophoresis, iSCAMS, etc), fermentation, advanced mass spec, genomics and sequencing, and proteomics core facilities with hands-on training or service by PhD-level staff scientists.

We apply innovative technologies to study RNA and RNP structure, dynamics, and interactions, such as rational RNA design and engineering, RNA cryo-EM, XFEL, ultrafast SAXS/WAXS, single-molecule fluorescence, crosslinking-mass spec., etc. Ongoing projects include structural and mechanistic elucidations of the T-box riboswitches in bacteria and Gcn2 kinase in eukaryotes in cellular stress responses. A second area addresses how numerous viral and host structured noncoding RNAs differentially manipulate immune protein activities such as PKR. For details refer to recent publications:

Suddala K.C & Zhang, J. (2019) High-affinity recognition of specific tRNAs by an mRNA anticodon-binding groove, Nat. Struct. & Mol. Biol., 26, 1114–1122.

Li S. et al., & Zhang, J. (2019) Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions, Nat. Struct. & Mol. Biol., 26, 1094–1105.

Hood, I.V. et al., & Zhang, J. (2019). Crystal structure of an Adenovirus Virus-Associated RNA, Nat. Commun. 10:2871

Incoming fellows are also encouraged to bring your own ideas that you could develop into research programs that you can then take to your independent PI positions. The NIH, NIDDK, and LMB are committed to the continued education and career development of trainees through numerous courses and workshops offered by OITE, FAES, and NIDDK.

Requirements: Interested candidates must have received (or be expecting) a Ph.D. or M.D. within the past five years in molecular biology, structural biology, biochemistry, cell biology, or a related discipline, have excellent oral and written communication skills, and be strongly self-motivated to participate in and design innovative and rigorous research projects. Prior experiences in structural biology are not required.

To apply: Please email a cover letter indicating preferred start date, CV, a brief summary of research interests, accomplishments, and career goals, and names and contact information for at least three references to: Dr. Jinwei Zhang, Email: jinwei.zhang@nih.gov. The NIH is dedicated to building a diverse community in its training and employment programs. DHHS/NIH is an Equal Opportunity Employer.


[Post Date: December 23, 2019]


Postdoc Free University of Bozen-Bolzano

View the Job Posting Here

job posting image

Description:

We have a call for a two years postdoc (24k€ a year) for candidates holding a PhD and with experience in protein purification (experience in cloning is desirable but not strictly required) to carry out:

Protein purification and crystallization, structural and functional characterization of enzymes,.

Within the project: “SupErA - Siderophore mediated iron uptake in Erwinia amylovora and Aspergillus fumigatus. Towards new strategies in plant and human health”

you will be involved in the characterization of the biosynthetic enzymes from the human pathogen A. fumigatus and be part of a collaborative effort between the University of Bolzano, the Medical University of Innsbruck (professor Hubertus Haas) and the Centre for Integrated Biology, University of Trento (professor Sheref Mansy) to develop new molecules to be used in therapy/diagnostics of both the human and the plant pathogen.

Bolzano is located in the Dolomites area offering many hiking, climbing and skiing opportunitie.


[Post Date: December 20, 2019]


Biochemistry/Crystallographer FoRx Therapeutics

job posting image

Description:

FoRx Therapeutics is a recently incorporated privately-held company based in Basel, Switzerland. It is backed by a syndicate of investors that include the Novartis Venture Fund, Pfizer Ventures, M Ventures, Omega Funds and LSP Venture Capital. FoRx Therapeutics focuses on drugging key molecular targets involved in the DNA Replication Stress, as a new approach in the development of targeted anticancer drugs.

We are seeking a Biochemist/Crystallographer to crystallize protein-drug complexes.

Requirements are a PhD in Biochemistry, Structural Biology or related Field. Postdoc experience is optional. First author publication in a relevant journal is required.

The successful candidate for this position will be a highly motivated individual who can communicate effectively, contribute beyond their strict discipline, be flexible and responsive to the changing needs of a dynamic entrepreneurial organization and fit well in small agile biotech team.

FoRx Therapeutics encourages and supports a diverse work environment as an Equal Opportunity Employer, offers a stimulating work environment and a competitive compensation package.

Interested candidates should send a cover letter describing research interests and career goals, along with a Curriculum Vitae to: hr@forxtherapeutics.com 


[Post Date: December 20, 2019]


Molecular Sciences Group Positions at Astex

job posting image

Description:

Astex has multiple positions open within the Molecular Sciences group based in Cambridge, UK.

Software developer/X-ray crystallography: http://astx.com/wp-content/uploads/2019/12/Xray-Software-Developer.pdf

Structural biologist/protein scientist: http://astx.com/wp-content/uploads/2019/12/Structural-Biologst-MAT-cover.pdf

Software developer/X-ray crystallography (sustaining innovation PDRA): http://astx.com/wp-content/uploads/2019/10/SI-Post-Doc-2019-Mol-Sci.pdf

Interested candidates should liaise with the HR department (email address can be found in the adverts).


[Post Date: December 20, 2019]


Research Assistant, Associate, or Postdoctoral Fellow

View the Job Posting Here

job posting image

Description:

A NIH (5 year budget) funded position for post-doctoral fellow is open in the Chicago Medical School, Rosalind Franklin University, in the lab of David Mueller,  for the study of the structure and function of the yeast ATP synthase and that of the protein defective in the juvenile form of Batten disease, Cln3.  We use a combination of x-ray crystallography and cryo-EM, with molecular biology, protein expression and purification, and yeast genetics.  Experience in biochemistry, including protein expression and purification is essential.   See this site to apply and for application details.


[Post Date: December 18, 2019]


Funded Biochemistry Technician Position in Marseille

job posting image

Description:

Context. A funded full-time Ingenieur d’Etudes position (A*MIDEX) is available in the new team of Elsa Garcin (Professor at AMU starting in January 2020, Chaire d’Excellence A*MIDEX; Adjunct Associate Professor at UMBC: https://sites.google.com/a/umbc.edu/garcinlab/) in the Laboratoire d’Information Génomique et Structurale (IGS), a CNRS/AMU laboratory located on the Luminy Campus of Aix-Marseille University. The IGS is a dynamic lab led by Chantal Abergel and a world-renowned expert in giant virus research (https://www.igs.cnrs-mrs.fr/les-publications/). Giant virus discovery was revolutionary for the field of virology, as they revived old debates about the concept of virus, their position in the tree of life, their biology, and the role they may have played in the emergence of life on earth. Characterizing new metabolic pathways in these viruses may therefore provide new clues about chemical and biological processes at the origin of life. The primary goal of the candidate will be to participate in the A*MIDEX Chaire d’Excellence Project “Structural Biochemistry of Novel Metabolic Pathways in Giant Viruses” led by Elsa Garcin.

Tasks. The principal activity of the successful candidate will be to conceive and perform experiments under the guidance and supervision of the project leader and in close collaboration with other team members. Learning new techniques specific to this project will be required. All results will be reported in lab notebooks, discussed with the project leader, and presented at lab meetings. English or French required.

Experience and skills. We are looking for an enthusiastic, organized, and motivated candidate. The successful candidate will have expertise in molecular biology, bacterial and/or eukaryotic protein expression, and protein purification. Mastering of basic lab techniques in molecular biology (PCR, cloning, site-directed mutagenesis) and biochemistry (protein production, purification, SDS-PAGE, Western blot) is required. Cell biology experience is a plus, but not required.

Constraints, risks. The successful candidate will work on projects depending heavily on cell biology and structural biology. The candidate will produce and purify proteins and complexes for structural studies by crystallography, small-angle x-ray scattering, electron microscopy, and NMR. Accordingly, the candidate will perform experiments with the non-pathogenic bacteria Escherichia coli. In addition, the candidate will perform experiments with the giant virus host, Acanthamoeba castellanii, and associated virus (Mimivirus, Megavirus, …). Work with these organisms will require strict adherence to safety protocols already in place at the IGS.

How to apply: Interested applicants should send their application by email to Elsa Garcin (garcin@igs.cnrs-mrs.fr), including a cover letter describing their motivation for joining the team, and curriculum vitae. They should also arrange for two letters of recommendation to be sent directly by email to Elsa Garcin (garcin@igs.cnrs-mrs.fr). Review of application materials will begin January 1st 2020.

Aix-Marseille University is an affirmative action, equal opportunity employer. Women and minority candidates are encouraged to apply.

Contract:

Start date: March 1st, 2020

Contract type: CDD Technique/Administratif

Duration: 12 months (renewable depending on results for a maximum of 33 months total)

Salary: salary will be calculated based on the successful candidate’s experience

Location: IGS, UMR7256 AMU/CNRS, Parc scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille, France Minimum level required: Bac+5 (Master 2 level)


[Post Date: December 18, 2019]


Funded Postdoctoral Position in Marseille

job posting image

Description:

Postdoctoral position in Structural Biology of Giant Viruses Context. A funded postdoctoral position (A*MIDEX) is available in the new team of Elsa Garcin (Professor at AMU starting in January 2020, Chaire d’Excellence A*MIDEX; Adjunct Associate Professor at UMBC: https://sites.google.com/a/umbc.edu/garcinlab/) in the Laboratoire d’Information Génomique et Structurale (IGS), a CNRS/AMU laboratory located on the Luminy Campus of Aix-Marseille University. The IGS is a dynamic lab led by Chantal Abergel and a world-renowned expert in giant virus research (https://www.igs.cnrs-mrs.fr/les-publications/). Giant virus discovery was revolutionary for the field of virology, as they revived old debates about the concept of virus, their position in the tree of life, their biology, and the role they may have played in the emergence of life on earth. Characterizing new metabolic pathways in these viruses may therefore provide new clues about chemical and biological processes at the origin of life.

Goals. The postdoctoral project aims at deciphering novel metabolic pathways in giant viruses, and is focused on structure-function studies of giant virus proteins. The successful candidate will join an interdisciplinary team of bioinformaticians, cell biologists, virologists, protein chemists, and structural biologists. The project will be carried out in close collaboration with partner labs (IBS Grenoble, spectroscopy; BIP, EPR) and groups and platforms at the Institut de Microbiologie de la Mediterannée (EPR, Proteomics, Microscopy, Biophysics).

Required education, experience, and skills. We are looking for a highly motivated, scientifically independent and creative fellow, who can contribute to a team environment. To be eligible for this postdoctoral position, candidates must have completed their PhD within the last two to five years at the start of the contract. A PhD in Biochemistry, Biophysics or a closely related discipline is required. Candidates should have a strong background in biochemistry, molecular and cellular biology, protein expression and purification. Prior research experience in at least one of the following areas is mandatory: protein or RNA biochemistry, x-ray crystallography, and electron microscopy. Experience with anaerobic techniques is a plus, but not required. Candidates should have strong communication skills, the ability to conduct research independently, to prepare manuscripts and presentations, and the ability and willingness to work with graduate and undergraduate students in the laboratory. Working language is English; knowledge of French is not required.

How to apply: Interested applicants should send their application by email to Elsa Garcin (garcin@igs.cnrs-mrs.fr), including a cover letter describing their current and future research interests and motivation for joining the team, and curriculum vitae with complete publication list. They should also arrange for three letters of recommendation to be sent directly by email to Elsa Garcin (garcin@igs.cnrs-mrs.fr). Review of application materials will begin January 1st 2020.

Aix-Marseille University is an affirmative action, equal opportunity employer. Women and minority candidates are encouraged to apply.

Start date: March 1st, 2020

Duration: 12 months (renewable depending on results for a maximum of 33 months total)

Salary: salary will be calculated based on the successful candidate’s experience

Location: IGS, UMR7256 AMU/CNRS, Parc scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille, France

Contact information: Elsa D Garcin (garcin@igs.cnrs-mrs.fr)


[Post Date: December 18, 2019]


NIH-Funded Post-Doctoral Position at the University of Illinois to Study the Ribosome Structure

job posting image

Description:

NIH-Funded Post-Doctoral Position in Structural Biology at the University of Illinois at Chicago (UIC) to Study the Structure and Function of the Ribosome

The Polikanov Laboratory at the University of Illinois at Chicago (IL, USA) is looking for a talented, skillful, and highly motivated researcher to fill the available NIH-funded Post-Doctoral Scholar position to study the structure and function of the bacterial ribosome.

The research in the Polikanov Laboratory is focused on understanding the basic principles of protein synthesis in bacteria, the modes of action of ribosome-targeting antibiotics, and the mechanisms of drug resistance at a structural level. More information about Dr. Polikanov research can be obtained from the most recent publications (https://www.ncbi.nlm.nih.gov/sites/myncbi/yury.polikanov.1/bibliography/50395623/public/?sort=date&direction=descending) or found on the web-page (https://bios.uic.edu/bios/people/faculty/yury-polikanov). The successful candidate will be involved in the determination of high-resolution structures of ribosome functional complexes with various protein translation factors, tRNAs, and antibiotics using macromolecular X-ray crystallography and potentially cryo-EM techniques.

Basic qualifications:

  • PhD in chemistry, biochemistry, biophysics, or a related field;
  • Practical skills with the most standard methods currently used in molecular biology, and biochemistry (such as protein expression, purification);
  • Experience in structural biology (cryo-EM or X-ray crystallography);
  • Experience in RNA biology field is desired;

The successful candidate is also expected to:

  • Act independently in terms of planning and executing the experiments;
  • Compile, analyze, and prepare data for publications;
  • Assist with training of graduate and undergraduate students.

Review of applications will begin immediately and will continue until the position is filled. Interested candidates should send their CV, cover letter, and contact information for three references directly to Dr. Yury Polikanov at yuryp@uic.edu. In the cover letter, the applicant should describe how his/her previous research accomplishments and scientific interests fit with the scope of the research in the Polikanov research group.

 Download PDF

[Post Date: December 18, 2019]


Scientist - Structure Based Protein Engineer - Lonza, Cambirdge, United Kingdom

View the Job Posting Here

job posting image

Description:

We are seeking a highly motivated and skilled (Senior) Scientist with experience in Structure-based Protein Engineering and Bioinformatics to join Lonza's Applied Protein Services (APS) Bioinformatics team based in Cambridge, UK.

Key responsibilities:

- The successful candidate will work on multiple customer projects focusing on in silico assessments and computational design of diverse proteins.

- You will gain experience on our proprietary platforms for antibody humanisation and deimmunisation, immunogenicity (Epibase) and manufacturability risk assessments to enhance the developability of potential biotherapeutics.

- The role involves working with customers ranging from small biotech to big pharma.

- Additionally, you will contribute to the development of innovative technologies to optimize proteins for the manufacturing processes.

Key requirements:

- PhD or equivalent in Structural Biology, Chemistry, Physics or Bioinformatics preferably with experience in industry.

- Highly experienced in protein structural analysis with emphasis on homology modeling and protein structure-based design. Strong understanding of molecular interactions is essential.

- Familiar with biomolecular simulation techniques, including molecular dynamics.

- Experienced working in Linux environment and scripting (knowledge of Python is essential; Perl is an advantage).

- Ability to generate high quality reports and promote effective communication with the customer.

- Advanced analytical and critical problem-solving skills, combined with scientific creativity.

- Interest in continuous improvements of processes by integrating innovative solutions.

- Ability to work as a team member, as well as independently with minimal supervision.

- Fluency in written and oral English, and strong, written, oral communication skills.


[Post Date: December 17, 2019]


Postdoc PROXIMA 2A Synchrotron SOLEIL

View the Job Posting Here

job posting image

Description:

There is a 2-year ANR-funded post doctoral position available to join the PROXIMA 2A team at Synchrotron SOLEIL (located near Paris, France) to develop Serial Crystallography methods. This is an ideal opportunity for a young scientist who wishes to learn about beamline instrumentation and a have chance to do some “weird and wonderful experiments”.

This position would be suitable for those with skills in general crystallography and programming. Knowledge in chemical crystallography would be advantageous.

Deadline for applications 31 January 2020.


[Post Date: December 13, 2019]


Postdoc Yale University

job posting image

Description:

A postdoctoral associate position is available in Dr. Elias Lolis’ lab at the Department of Pharmacology, Yale University, to work on the structures of chemokine receptor (GPCR) complexes. The chemokine and chemokine receptors function as homeostatic and/or inflammatory proteins and are targets in a number of disorders including autoimmune disease and cancer. This position represents an opportunity for a postdoctoral scientist to develop their expertise as well as broaden their experience. The successful candidate will participate with a larger research team that includes graduate students and postdocs working on mouse knockouts of these receptors in a variety of diseases and the development of therapeutics. The project will combine structural techniques such as macromolecular crystallography with biophysical and biochemical techniques to investigate the structural basis of GPCR signaling and its inhibition. The project also includes soluble proteins. Opportunities for cryo-EM studies are also available within the department for large complexes. The lab has all necessary equipment needed for the project and access to the Macromolecular X-ray Crystallography Core Facility that contains an Agilent HPLC with online Wyatt SEC-MAS, Nano-ITC, crystallization robotics (LCP Formulatrix NT dropsetter, TTP LabTech Mosquito and Art Robbins Gryphon), temperature-controlled crystallization incubators, Formulatrix RI-1000 with visible, UV, and fluorescent capabilities, and Dectris Pilatus 200K Pixel Array Detector with a Rigaku 007 generator. We have access to various beamlines in the US. The lab is part of the SBGrid (sbgrid.org) consortium.

Qualifications:

The candidates should hold a PhD, be motivated to independently solve problems, and a have a strong background in structural biology. Experience with Sf9 protein expression, purification and biochemical characterization is required.  Prior experience in membrane protein biochemistry and computational skills such as a familiarity with the LINUX operating system is a plus.

The postdoc position is available immediately. The application must include:  

  • A letter of intent stating the scientific interests, technical skills, and previous experience of the candidate. The applicant should also state when the candidate will be able to start working at Yale.
  • CV including field and date of (expected) graduation, if the applicant has not graduated yet, and a list of publications, with the contact information of at least two references.

Interested candidates should be sent their application to elias.lolis@yale.edu.


[Post Date: December 10, 2019]


Project Leader for the ID30A-1/MASSIF-1 MX Beamline Upgrade

View the Job Posting Here

job posting image

Description:

The EMBL-Grenoble is currently recruiting a project leader for the ESRF ID30A-1/MASSIF-1 MX beamline upgrade project. More information can be found at the link.


[Post Date: December 9, 2019]


SFX PostDoc ASU, Tempe, Arizona

View the Job Posting Here

job posting image

Description:

We are currently looking for a new PostDoc to join our serial crystallography data analysis team at Arizona State University. For more information please see the job posting at https://apply.interfolio.com/69791 or contact John Spence, John.Spence@asu.edu

To apply, please send electronically to  http://apply.interfolio.com/69791 the following materials:  (a) a cover letter, (b) a CV, (c) a publication list, (d) a detailed summary of research experience and interests, and (e) 3 reference letters. 


[Post Date: December 9, 2019]


Group Leader of Structural Biology in Viva Biotech

View the Job Posting Here

job posting image

Description:

Viva biotech is a leading CRO organization established in 2008 and located in Shanghai, China. As a customer-focused company with industry-leading capabilities, Viva provides structure-based drug discovery, biologics, and medicinal chemistry services to global pharmaceutical and biotech companies for their pre-clinical stage innovative drug development. Viva biotech is in a rapid expansion mode since its successful IPO in the Hong Kong Stock Exchange on May 9th, 2019. We now have openings for group leaders in structural biology and biochemistry. Anyone who is interested in the position, please send CV to hr@vivabiotech.com

Job title: Group Leader in Structural Biology

Job Description: We are seeking a highly motivated scientist to join our biology department as a protein group leader. Candidate will lead the structural biology team to carry out the biochemistry studies and gene-to-structure studies that elucidate the interactions between small molecules/peptides and their targets. The ideal candidate for this position must have the ability to handle multiple projects simultaneously in a fast-paced, dynamic and highly multi-tasking environment.

Responsibility: 1. Manage multiple projects simultaneously and lead a group of scientists to achieve clients’ goals successfully. 2. Conceive, plan, design and implement a highly efficient project proposal and workflow to deliver fast turn-around results at client requested quality. 3. Demonstrate strong customer and service focus. Effectively collaborate with colleagues from different departments, collaborators and external clients or partners by active daily communication, telecom conference, etc. 4. Prepare and deliver presentations of project results to clients timely. 5. Provide scientifically sound guidance, resolve and promptly response to any issues, problems or challenges which may arise. 6. Identify and implement improvements to work processes.

Qualifications: 1. The candidate should have a Ph.D. in Genetics, Molecular Biology, Biochemistry, Cell Biology or related field. 2. A minimum of 2 years of industry or academic relevant research experience is preferred. However, an outstanding Ph.D. graduate would be considered as well. 3. Have a proven track record in scientific achievement, including structural biology, illustrated in a list of publications. 4. Excellent organizational and communication skills are essential. 5. Working experience and/or in-depth knowledge in every step of protein crystallography which includes, but not limits to, bioinformatics, construct design, cloning, protein expression, purification, crystallization, X-ray data collection and processing, structure determination, modeling, and interpretation as well as common biophysical assay techniques, such as TSA, ITC, SPR, etc. 6. Strong written and verbal communication skills in both English and Chinese are mandatory. 7. Expertise in protein crystallization and crystal handing. 8. Experience with membrane protein production and crystallization is a plus. 9. Extensive data collection experiences at synchrotron. Able to lead a group of scientists to conduct data collection independently at synchrotron would be desired. 10. Proficient in structure biology related software, such as XDS and CCP4 is essential. 11. Demonstrated success in solving protein structures using MR method and experimental phasing. Working experience with SeMet-protein crystallization and structure determination with MAD or SAD method would be a plus. 12. The ability to analyze crystal structure, interpret, summarize, and present scientific results in a clear, concise, accurate manner to both clients and team members. 13. Experience in industry and/or with structure-based drug design is a plus. 14. Familiar with Linux system and working knowledge of system maintenance. A certain level of programming ability to increase work efficiency would be a big plus. 15. Demonstrated leadership in project management, experience with training junior would be a plus.


[Post Date: December 9, 2019]


Research Associate - Biological Structure Annotation Specialist (Biocurator)

View the Job Posting Here

job posting image

Description:

Analyze, curate, and validate macromolecular structures from the PDB community. Participate in exciting projects with significant impact on the scientific community.

RCSB PDB (RCSB.org), the US data center for the global PDB archive, serves thousands of Data Depositors in the Americas and Oceania and makes 3D macromolecular structure data available at no charge and without usage restrictions to more than 1 million rcsb.org users worldwide.

Deposition/Biocuration Services provide expert deposition, validation, biocuration, and remediation services to Data Depositors worldwide, ensure PDB data are Findable, Accessible, Interoperable, and Reusable (FAIR) by providing expert data curation which is critical for biological data resources, and develop and promote community-endorsed data standards for archiving and exchange of global structural biology data.

Roles:

  • Analyze, curate, and validate macromolecular structures from the PDB community
  • Participate in exciting projects with significant impact on the scientific community
  • Communicate daily with members of the research community
  • Participate in fun outreach activities

Why join us:  

  • Influence the development of structural biology as a field representing high scientific standards. 
  • Be part of a friendly and collaborative working environment with excellent professional development opportunities. 
  • At Rutgers, this academic position offers New Jersey state benefits and a faculty-level salary.

Knowledge and skills:

  • Experience in structural biology with a PhD in a relevant field required
  • Strong knowledge of small molecule chemistry or 3DEM preferred
  • Experience in bioinformatics, cheminformatics, or computer scripting would be an advantage 

The successful candidate should be self-motivated, pay close attention to details, possess strong interpersonal communication and writing skills, and have the ability to handle multiple projects.


[Post Date: December 3, 2019]


Postdoctoral Fellows in the Structural Biology Group ESRF

View the Job Posting Here

job posting image

Description:

Context & Job Description

You will participate in ongoing in-house research programmes, and in the operation of the beamline, including providing support to external users as local contact.

The ESRF Structural Biology (SB) Group currently operates 8 end-stations for Structural Biology providing a wide range of state-of-the-art facilities for experiments in macromolecular crystallography (MX), BioSAXS and cryo-electron microscopy (cryo-EM). Additional ancillary techniques such as in crystallo spectroscopy and experiments based on high pressure cryo-cooling are also provided for, as is a laboratory for protein expression and purification. A major activity for the group is the development of new experimental methodology and of integrated software for the automation of our beamlines.

Commensurate with the re-commissioning of our beamlines following the construction of the ESRF Extremely Brilliant Source (http://www.esrf.fr/Apache_files/Upgrade/ESRF-orange-book.pdf; http://www.esrf.fr/about/upgrade) we invite applications for post-doctoral researchers (3-year, fixed term positions) in the following areas:

  • Development of millisecond spectroscopy for time-resolved experiments.
  • Data analysis for synchrotron serial crystallography (SSX) experiments
  • Automation of image analysis pipelines for cryo-electron microscopy.
  • Development of new methodologies for fast sample delivery in SSX experiments
  • Cryo-electron microscopy, particularly the single particle reconstruction of macromolecular complexes.
  • Development of microfluidic devices for the use in bioSAXS experiments

Further information may be obtained from Gordon Leonard (email: leonard@esrf.fr).

These positions are open until filled.

Expected Profile

  • PhD in Structural Biology or a closely related area, obtained less than 3 years ago.
  • A strong interest in the use of synchrotron radiation in the study of biology is desirable.
  • Ability to interact with multi-disciplinary staff and facility users.
  • Proficiency in English (working language at the ESRF).


[Post Date: December 3, 2019]


Beamline Scientist ESRF

View the Job Posting Here

job posting image

Description:

Context & Job Description

The ESRF provides access to state-of-the art facilities for diffraction, solution scattering and cryo-electron microscopy experiments in Structural Biology. These include 6 beamlines dedicated to macromolecular crystallography (MX), many of which will be upgraded and/or refurbished as part of the ESRF Extremely Brilliant Source (EBS) project.

As a Beamline Scientist, your missions are the following:

  • Manage the day-to-day operation and the scientific development of the ESRF’s MASSIF-3 beamline, helping to develop of instrumentation, software and methods that will be important for all of the Structural Biology Group’s MX facilities at a post-EBS ESRF.
  • Support external user research by acting as Local Contact on MASSIF-3 and on the ESRF’s other MX beamlines.
  • Develop scientific research projects based on the use of MX in Structural Biology. Here you should be able to interact with, and contribute to, programmes and developments (e.g. methodologies for synchrotron serial crystallography and multi-crystal data collection; room-temperature time-resolved MX, in crystallo optical spectroscopy) on-going in the Structural Biology Group.

Expected Profile

  • PhD in Structural or Molecular Biology or a related subject and several years of postdoctoral experience in synchrotron-based Structural Biology
  • Demonstrable experience in the development of software and/or instrumentation for synchrotron-based Structural Biology
  • A strong scientific research profile
  • The ability to interact with multi-disciplinary staff and facility users
  • Good time management skills and ability to prioritize
  • Proficiency in English (working language at the ESRF)


[Post Date: December 3, 2019]


Protein Scientist / Crystallographer Exscientia

View the Job Posting Here

job posting image

Description:

Exscientia is at the forefront of Artificial Intelligence (AI) driven drug discovery.  Our AI driven systems actively learn best practice from vast repositories of drug discovery data and are further enhanced with knowledge acquired from seasoned drug hunters. Our team are passionate in the pursuit of excellence and at Exscientia you will enjoy a flexible, inspiring and dynamic working environment. Exscientia is an equal opportunity employer committed to building a culturally diverse team.
 
The Discovery Biology team in Exscientia is responsible for enabling small-molecule therapeutic projects by providing GPCR biology, protein production, biophysical and crystallographic capabilities. The team works on diverse target classes and strongly integrates with the Centaur Chemist AI platform to support the transformative efficiency improvements in clinical candidate discovery demonstrated with our systems.
 
We are looking to recruit an experienced scientist specialising in X-ray crystallography, protein expression and purification to support the discovery of new therapeutic molecules.  The candidate will be responsible for the crystallization and the structure determination of protein-small molecule complexes by x-ray crystallography. The work will include protein production for structural purposes, crystallization, X-ray data collection, structure determination, and analysis.


[Post Date: November 25, 2019]