Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to firstname.lastname@example.org.
Schrödinger’s mission is to revolutionize drug discovery through the use of breakthrough computational methods. We are currently looking for outstanding individuals to join our drug discovery group and contribute to our rapidly expanding portfolio of drug discovery collaborations.
Our Drug Discovery Group of over 60 scientists includes designers, modelers, computational chemists, medicinal chemists, crystallographers, biochemists, and biologists with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers as well as a large scale compute infrastructure. Four of the programs we’ve worked on in the past 7 years have progressed into the clinic; two are still progressing through trials and two have been approved by the FDA.
We are looking for a highly motivated structural biologist with demonstrated experience in the fields of X-ray crystallography and cryoEM. The ideal candidate will have a thorough understanding of both of these methodologies and broad experience using the computational tools required for structure determination.
Essential Qualifications, Skills and Experience:
Desirable Skills and Experience:
Pay and perks:
Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, stock options, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have catered meals in the office every day, a company culture that is relaxed but engaged, and over a month of paid vacation time. Our Administrative and Human Resources departments also plan a myriad of fun company-wide events - last summer we went tubing down the Delaware River! New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been selected as one of Crain's New York Best Places to Work 2018.
Sound exciting? Apply today and join us!
As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company’s mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, national origin, citizenship status, marital status, union status, sexual orientation, or gender identity. To us, “diversity” isn’t just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. Greater diversity doesn’t just mean better headlines or public images—it means increased adaptability and profitability.
[Post Date: April 2, 2020]
Postdoc Department of Molecular and Cellular Biochemistry in the College of Medicine at the University of Kentucky
A postdoctoral position is available immediately in the laboratory of Dr. Emilia Galperin in the Department of Molecular and Cellular Biochemistry in the College of Medicine at the University of Kentucky to work on externally funded, multi-year projects. The overall goal of the lab is to understand the molecular mechanisms of spatial and temporal regulation of signal transduction. Preference will be given to applicant with a strong background in protein purification and characterization; experience in other biophysical methods such as X-ray crystallography is a plus. The successful applicant will be a highly motivated individual with good communication skills, will have a proven publication record, and the ability to work independently as well as within a group. This work is in collaboration with the protein structural group of Dr. David Rodgers.
The applicant must currently have a Ph.D. in Biochemistry or a related field. The appointment will be for 1 year with renewal up to 5 years. Interested candidates should assemble a i) cover letter, ii) CV, iii) list of references, and iv) first-author manuscript that have been published or accepted for publication. The cover letter should describe the candidate's research experience, scientific interests, and preferred start date.
E-mail the application as a single PDF file to email@example.com.
[Post Date: March 16, 2020]
Berkeley Lab's Molecular Foundry has an exciting opportunity for a technical staff position in the biological sciences. This person will work with staff and users of the Biological Facility to advance basic scientific research in the areas of synthesis and characterization of biological structures, biopolymers, and nanocrystals. Toward this goal, the person will assist in project planning, instrument training and scientific interpretation, as well as providing help with basic laboratory safety, oversight and maintenance. The position also provides an opportunity to pursue research, either in collaboration with users or independently. A bachelor's degree in one of the biological or chemical sciences is required, and candidates with M.S. or Ph.D. will be preferred. For more information and to apply, please go to: https://jobs.lbl.gov/jobs/scientific-engineering-associate-biological-nanostructures-2594
[Post Date: March 9, 2020]
Postdoc position on eye-disease structural biology at Stanford University
Prof. Vinit Mahajan’s group in Department of Ophthalmology, Stanford School of Medicine is seeking applications for a postdoctoral fellow position from ambitious, enthusiastic, and recent Ph.D. holders or graduate students who are expecting to finish his/her graduate degree in structural biology, biophysics, biochemistry, bioengineering, molecular cell biology, or pharmaceutics. The successful candidate will be a structural biologist with strong interests in biomedical, translational, and pharmaceutical sciences, who can carry out one or few structural biology projects for eye disease proteins. Dr. Mahajan is a physician/surgeon, and a scientist, who is the vice chair for research and the director of Molecular Surgery Program of the Stanford’s Byers Eye Institute. He runs a large interdisciplinary group of scientists and clinicians, who are actively seeking for therapeutics and cure for eye patients (https://mahajanlab.stanford.edu/).
Mahajan group is pursuing structural biology research focused on eye diseases in a close collaboration with Prof. Soichi Wakatsuki, Structural Biology Department, Stanford School of Medicine and SLAC National Accelerator Laboratory (http://med.stanford.edu/wakatsukilab.html). Dr. Wakatsuki’s interests cover protein-protein interactions (Comerci & Herrmann et al. Nat. Comm. 2019; Herrmann et al. PNAS 2019), enzyme dynamics (Stoffel et al. PNAS 2019), and structure-based drug design (Hwang et. al., Nat. Comm. 2018).
Both Drs. Mahajan and Wakatsuki are members of Stanford BioX and ChEM-H, interdisciplinary institutes encompassing three Stanford Schools: Medicine, Chemistry, and Engineering. This provides a truly interdisciplinary research environment at the crossroad of medical science, structural biology and state-of-the art bioimaging technologies. The two groups collaborate closely on structural biology research on eye disease proteins. See one of our recent publications on the structure-function investigation of a cysteine protease: Calpain-5 (Velez et al. Cell Reports 2020). Other ophthalmologic structural biology work includes: 1) targeted structure-functionomics for eye diseases; and 2) structure-based drug design for retinal degeneration.
SLAC provides state-of-the-art multi-modal structural biology technologies covering a wide range of spatiotemporal resolutions. SLAC hosts large scale infrastructures: SSRL Structural Molecular Biology (SMB), and Linac Coherent Light Source (LC/LS) providing synchrotron and X-ray beams for crystallography, scattering and spectroscopy, and Stanford-SLAC CryoEM Center (S2C2) providing access to the cryoelectron microscopy (Cryo-EM) instruments for both single particle structural analysis and tomography (CryoET).
Qualifications: Ph.D. or equivalent degree in the relevant fields within the last 3 years. English proficiency is mandatory. Familiarity with one or more of structural biology techniques, including X-ray crystallography, small angle X-ray scattering, cryoEM/ET, biocomputation, and hybrid methods, as well as strong background and experiences in sample preparation and characterization. The applicant must be a good team player. Experiences in scientific writing and grant application to US funding agencies are plus.
Deadline: as soon as the position is filled.
[Post Date: March 6, 2020]
Postdoc Duke University School of Medicine
Applications are invited for a postdoctoral fellow position in the laboratory of Seok-Yong Lee at Duke University School of Medicine to work on the structure and mechanisms of ion channels and transporters. Please see our web page for more details on our research program: https://sites.duke.edu/leelab/
Candidates must have obtained a Ph.D. degree within a year and possess a strong background in protein biochemistry (protein expression and purification) and structural biology (single particle cryo-electron microscopy or X-ray crystallography). Additional expertise in membrane protein biochemistry is a plus point. Strong verbal and written communication skills are highly desirable.
The Lee lab is fully equipped for structural studies of membrane proteins and has frequent access to the 300 kV Titan Krios TEM with K3 and Falcon III detectors in the Duke University.
If you are interested, please email your curriculum vitae, a cover letter describing your research experience and interests and contact information for 2 references to firstname.lastname@example.org
[Post Date: March 3, 2020]
Postdoc Urbanowicz Lab at the University of Georgia's Complex Carbohydrate Research Center
The Urbanowicz Lab at the University of Georgia's Complex Carbohydrate Research Center (www.ccrc.uga.edu) is looking for a motivated postdoctoral researcher to carry out a research project in plant cell wall biology investigating structure/function of carbohydrate active enzymes. Successful applicants will join a multi-disciplinary team comprised of scientists from the Complex Carbohydrate Research Center and the New Materials Institute together to pursue research funded by the DOE Center for Bioenergy Innovation (https://cbi.ornl.gov) and the DOE Center for Plant and Microbial Carbohydrates. The position is available as early as March 1st, 2020 and comes with a comprehensive benefits package and a competitive salary.
Candidates must hold a Ph.D. in chemistry, biochemistry, plant biology or a related discipline. Preference will be given to candidates who have hands-on experience with heterologous expression and purification of recombinant proteins. Strong communication skills and fluency in written and spoken English are essential as is the ability to work in a collaborative scientific environment.
Candidates should submit their applications as a single PDF document by email to Breeanna Urbanowicz (email@example.com). The document must contain: (i) a cover letter describing their research interests, career goals and motivation for the position, (ii) a current CV, and (iii) the names and contact information for three individuals willing to provide professional letters of support.
For further information, please contact Dr. Breeanna Urbanowicz (firstname.lastname@example.org) with questions related to these exact positions.
Dr. Breeanna Urbanowicz completed her PhD at Cornell University and is currently an Assistant Professor in the Department of Biochemistry and Molecular Biology at the University of Georgia. She is faculty member of UGA’s Complex Carbohydrate Research Center and New Materials Institute and is a project leader in the US-DOE Center for Bioenergy Innovation (CBI), the US-DOE Center of Plant and Microbial Carbohydrates, and the NSF-funded Center for Bioplastics and Biocomposites (CB2). Her core research is centered on the structure, biosynthesis and biological function of the plant cell wall, a cellular component that is integral to many facets of plant biology. The tools and approaches developed are paving the path forward toward deeper analysis of glycopolymer synthesis and deconstruction pathways used by plants and other organisms, and are now being applied towards the development of new bio-based plastics and coatings.
[Post Date: March 3, 2020]
Postdoc Position at Cold Spring Harbor Laboratory
The Furukawa Laboratory at Cold Spring Harbor Laboratory (CSHL) located in the suburb of New York City postdoctoral positions available for those interested in dissecting molecular machinery involved in the brain physiology and neuron-cancer interfaces by a combination of cryo-EM, electrophysiology, antibody engineering, reagent development, crystallography, and more.
Cold Spring Harbor Laboratory is equipped with Titan-KRIOS electron microscope/K3 direct electron detector and has a frequent access to the NSLS-II synchrotron beamlines (AMX and FMX). Our group is also equipped with electrophysiology rigs and other biophysical tools. CSHL has excellent core facilities for antibody engineering, imaging, and protein crystallization.
Please visit http://furukawalab.labsites.cshl.edu/ for detailed info on research, publication, the lab culture, and the training track record. Our group at CSHL offers a unique training environment for research and career development. A qualified applicant should hold Ph.D. or expect to hold Ph.D. within 1 yr in the area of biochemistry, biophysics (structural biology, electrophysiology, smFRET, etc), and molecular neuroscience. Please send a CV and a cover letter briefly describing current research and potential future interests in the Furukawa lab to Prof. Furukawa at email@example.com
[Post Date: March 2, 2020]
One post-doctoral position in structural biology applied to drug discovery is available at Istituto Italiano di Tecnologia within the Molecular Modeling and Drug Discovery Research Line, led by Dr. Marco De Vivo.
[Post Date: March 2, 2020]
Post-Doctoral Scientist position BrichosPharm
Post-Doctoral Scientist (m/f) ZoBio (www.zobio.com) was founded in 2004 and is located in Leiden, The Netherlands. ZoBio offers innovative research services in the field of small-molecule drug discovery to the pharmaceutical and biotech industries. Our international team of 26 people covers four fields of expertise: Protein Engineering and Production, Assay Development and Screening, Structural Biology, and Medicinal Chemistry. We are currently looking for a highly motivated post-doctoral scientist to strengthen our team and lead an ongoing multiyear drug discovery project called BrichosPharm which is partly funded by EurostarsTM and is geared towards modulating BRICHOS for an Alzheimer’s Therapy. A track record in running projects that require protein production, biochemical assays and structural biology (X-ray crystallography/NMR) is a requirement. You will work with minimal supervision and will effectively cooperate with other research groups at ZoBio. Team spirit, excellent organization and communication skills are essential.
RESPONSIBILITIES • Lead an ongoing multiyear project. • Responsible for planning and performing of all the experimental work with periodic reporting to the ZoBio management/funding agency/collaborative partners. • Close interaction within various research groups at ZoBio and with external partners involved in the project collaboration. • Maintain up-to-date understanding of the state-of-the-field. • You are also expected to contribute to other projects at ZoBio. REQUIREMENTS • PhD in relevant field with 1-2 years of experience in an industrial or collaborative setting. • Experience in recombinant protein production and characterization from E.coli. Experience with stable isotope labeling is a plus. Hands on experience with chromatography systems such as AKTA, Biorad is essential. • Experience with structural biology methods (X-ray/NMR) for protein-ligand interaction is necessary. • In-depth knowledge of enzyme activity measurements, including both theory and practice is required • Able to work in a team in a result-driven, goal-oriented environment. • Strong analytical and problem-solving skills are required. • Good written and verbal communication skills are essential.
The appointment will be for an initial period of 12 months with a possibility to extend. A tailored remuneration package will be proposed in line with individual qualifications and experience. The position is available immediately; the evaluation and assessment of candidates will run until the position is filled but not later than the end of March 2020. We prefer to fill this position as quickly as possible. Please send your CV, motivation letter and names of potential referees to with the subject: “Post-Doctoral Scientist position BrichosPharm” to Denys Pogoryelov pogoryelov@EM.UNI-FRANKFURT.DE
[Post Date: February 24, 2020]
Postdoctoral Fellow Position at University of Texas Health Science Center San Antonio
The laboratory of Dr. Yogesh Gupta at University of Texas Health Science Center in San Antonio (UT Health San Antonio™) is seeking a highly motivated and enthusiastic Postdoctoral Fellow to study protein-nucleic acid interactions in post-transcriptional gene regulation and chromatin biology. We combine various structural biology tools (X-ray, cryo-EM, NMR) with in silico, and cell-based methods to address basic mechanistic questions, and exploit this knowledge for drug development. Our well equipped lab is physically located within the Greehey Children’s Cancer Research Institute (Greehey CCRI) at UT Health San Antonio. In addition, we have full access to an extensive array of institutional core facilities (Biochemistry core, CIDD, Research core labs), and regular access to synchrotron beamlines.
Applicants with demonstrated experience in protein biochemistry and structural biology, and keen interest in studying large protein-nucleic acid assemblies by X-ray and cryo-EM are preferred. Candidates are expected to possess strong organizational, interpersonal skills, and ability to work as part of a team. Candidate should hold (or soon expect to hold) a Ph.D. or equivalent degree in a related discipline. Prior experience in X-ray crystallography, biophysical methods (SPR, AUC, ITC, MST etc.), and enzyme kinetics is desirable.
Salary is competitive ($52,704 per year plus standard fringe benefits of UT Health San Antonio). San Antonio offers affordable cost of living and there is no state income tax in Texas.
Please visit the websites below to learn more about our work and future directions –
If interested in applying, please send a short description of your research accomplishments, and current CV with a list of three (3) references to Dr. Yogesh Gupta (email: firstname.lastname@example.org).
The Greehey Children’s Cancer Research Institute is a unique specialized cancer research center focusing on basic and translational research in childhood cancer and occupies a state-of-the-art 100,000 sq. foot research facility on the university’s Greehey Academic and Research Campus.
San Antonio is the nation’s seventh largest city and is located at the edge of the beautiful Texas Hill County. San Antonio offers a rich, multi-cultural community, affordable cost of living, excellent weather and a thriving biomedical industry.
All Postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Opportunity/Affirmative Action Employer including protected veterans and persons with disabilities.
[Post Date: February 19, 2020]
There is an opening for a post doc with experience in recombinant protein production and purification, enzyme kinetic analyses and structural biology (crystallization, cryoEM) in our group in University of Oulu, Finland. Our research focuses on the enzyme family of 2-oxoglutarate-dependent dioxygenases and their potential as therapeutic targets. Our main interests are in the hypoxia-inducible factor prolyl 4-hydroxylases, P4H-TM and histone demethylases. We offer a research environment with excellent technological facilities and a motivating and supporting community. Deadline Feb 21.
Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WG Jr. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science. 2019 Mar 15;363(6432):1217-1222.
Laukka T, Myllykoski M, Looper RE, Koivunen P. Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases. J Mol Biol. 2018 Sep 14;430(18 Pt B):3081-3092.
Rahikkala E, Myllykoski M, Hinttala R, Vieira P, Nayebzadeh N, Weiss S, Plomp AS, Bittner RE, Kurki MI, Kuismin O, Lewis AM, Väisänen ML, Kokkonen H, Westermann J, Bernert G, Tuominen H, Palotie A, Aaltonen L, Yang Y, Potocki L, Moilanen J, van Koningsbruggen S, Wang X, Schmidt WM, Koivunen P, Uusimaa J. Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome). Genet Med. 2019 Oct;21(10):2355-2363.
[Post Date: February 19, 2020]
Surrozen is a biotechnology company focused on discovering and developing novel regenerative medicines with a focus on unlocking the powerful self-renewal properties of the body through specific control of the Wnt signaling pathway.
Surrozen was founded by five leading-edge scientists: K. Christopher Garcia, Ph.D., Roel Nusse, Ph.D. and Calvin Kuo, M.D., Ph.D. from Stanford University; Claudia Janda, Ph.D. from the Princess Maxima Center for Pediatric Oncology; and Hans Clevers, M.D, Ph.D. from the Hubrecht Institute and Princess Maxima Center. Each has conducted extensive research on Wnt signaling, with findings that together shape Surrozen’s technology and approach to therapeutic development.
This position with focus on Antibody Developability and Structural Biology, within the Protein Sciences Group, is a great opportunity for experienced associates as well as recent graduates to expand their skills in state-of-the-art experimental techniques to support thriving high-throughput developability assays and participate in structural biology studies while accelerating therapeutic discovery and development in regenerative medicine.
[Post Date: February 19, 2020]
Postdoc University of California San Francisco
Would you like to use your expertise to combat important problems affecting public health? Are you interested in combining your skills in structural biology with quantitative genetic approaches? Do you enjoy working in a collaborative, intellectually stimulating environment, situated in one of the most exciting (and beautiful) cities in the world?
The Rosenberg lab, located at University of California - San Francisco (UCSF) and affiliated with the Chan-Zuckerberg Biohub, has an NIH funded position for a postdoctoral scholar to continue our work characterizing the structural biology of host-pathogen interactions. You will have exciting opportunities to combine your structural findings with functional characterization using microbial genetics. In recent work, we have used a variety of structural techniques to characterize bacterial virulence systems (see for example, PMID: 31886769, PMID: 28252385, or PMID: 25865481). We have also developed novel genetic tools that can be used to study how pathogens interact with their hosts (PMID: 30617347, PMID: 31481541, or PMID: 31073154).
We are looking for a Ph.D. candidate or recipient trained in electron microscopy or x-ray crystallography and with an interest in expanding their structural tool kit. Our facilities at UCSF include access to a Talos Arctica Cryo-TEM for screening and a Krios with a K3 bioquantum for data collection, as well as several other instruments for negative stain and additional data collection. We also have new funding for the installation of a Cryo-FIB and a cryo-fluorescence microscope to facilitate CryoCLEM. Additionally, there is a state-of-the-art, automated facility for protein crystal growth, and essentially unlimited access to synchrotron time at ALS. Many shared instruments are available for biophysical characterization of proteins.
If you are interested, please contact Laura Wise (Laura.Wise@ucsf.edu) with a cover letter and a CV describing your work and we will be in touch! Please submit your application before April 1'st for full consideration, though the start date is negotiable.
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
[Post Date: February 12, 2020]
Research Fellow & Research Technician
Structural Biology Core at Dana-Farber Cancer Institute has multiple openings at Scientist levels. Please see the details and apply online using the links below.
[Post Date: February 12, 2020]
Postdoc Florida State University
One postdoctoral position is available immediately in an enzymology laboratory to elucidate mechanisms of DNA/RNA synthesis, DNA lesion bypass, and base excision repair catalyzed by various human and viral DNA/RNA polymerases, and to mechanistically investigate gene editing enzymes including CRISPR/Cas9 and Cas13a. Background in structural biology (X-ray crystallography and/or CryoEM), biophysics, protein purification, and recombinant DNA techniques is preferred. An important criterion for selection will be the ability of the desired individual to pursue independent research in an active multi-disciplinary setting. Interested candidates should send a CV and a statement describing experience, goals, and reasons for the interest in this position, and arrange to have three letters of recommendation sent to Dr. Zucai Suo, Eminent Professor and Dorian and John Blackmon Chair of Biomedical Science, Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL. Dr. Suo can be contacted by email (email@example.com). Further information about the research projects in the Suo Lab can be obtained from https://med.fsu.edu/index.cfm?page=suolab.research.
Employer: Florida State University College of Medicine
Location: Tallahassee, Florida
Salary: NIH guidelines for post-doctoral salaries + benefits
Discipline: Life Sciences, Biochemistry, Biology, Biophysics, Structural Biology, and Biomedical Sciences Position Type: Full Time Organization Type: Academia Job Type: Postdoc
[Post Date: February 12, 2020]
Postbaccalaureate and postdoc position in membrane protein structure and function lab at the NIH
Postbac position in my lab for two years starting from the coming summer. The NIH Postbac IRTA program provides recent college graduates who are planning to apply to graduate or professional (medical/dental/pharmacy) school an opportunity to dofull-time research at the NIH.
For this position I am looking for someone who has experience with protein purification, has good organizational skills and work ethics, and the right mindset to pay attention to nitty-gritty details that are essential for working with membrane proteins. The candidate should apply to the NIH Postbac Program (https://www.training.nih.gov/programs/postbac_irta) and get in touch with me as well.
Postbac candidates have to be US citizens or permanent residents.
Postdoctoral position EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT, BETHESDA, MD AND SURROUNDING AREA
There is an open postdoctoral position for a membrane protein structure-function project in my lab at the NIH. We are currently focusing on integral membrane enzymes (Science. 2018, doi: 10.1126/science.aao6326) and transporters of transition metal ions (J Biol Chem. 2018, doi: 10.1074/jbc.M117.817478).
The research group of Dr. Anirban Banerjee at the National Institutes of Health (NIH) is seeking candidates for postdoctoral fellows . The broad interests of the lab are in membrane protein structure and function. We combine structural techniques such as macromolecular crystallography and cryoEM together with biophysical and biochemical methods such as reconstitution based assays, high resolution microscopy and small molecule screening to investigate the structural bases of the mechanisms of a number of membrane proteins.
The lab has state-of-the-art equipment and facilities. We have dedicated periodic access to the 22-ID beamline at the APS, for crystallographers at the NIH, as well as access to 23-ID and 24-ID beam lines at the APS. NICHD is now part of a consortium that has access to a Titan Krios on a regular basis. Our laboratory is part of the Cell Biology and Neurobiology Branch in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
The candidates should hold a Ph. D. degree (by the time of joining the lab), be author of at least one first author publication and have a strong background in biochemistry or structural biology. Experience with basic molecular biology, protein expression, purification and biochemical characterization are required. Prior experience in membrane protein biochemistry or mammalian expression system for protein purification will be added advantages.
It is absolutely essential the candidate is motivated and prepared to put in the best efforts for fruition of the project goals. We are a small, friendly lab and ability to work as part of a cohesive group is important.
[Post Date: February 10, 2020]
A postdoctoral position is available at Princeton University in the laboratory of Prof. Alexei Korennykh. We work on understanding intriguing molecular mechanisms of human stress responses, immune defenses and metabolism. We use X-ray crystallography, Cryo-EM at Princeton’s state of the art facility, biochemistry, biophysics, cell biology and high-throughput RNA sequencing.
To read about our work:
Essential Qualifications: Ph.D. degree.
Favorable Qualifications: Structural Biology (X-ray or cryo-EM), Cell Biology (mammalian tissue culture, CRISPR applications, lentiviral work, RNA-seq), Biochemistry, Biophysics, RNA biochemistry, Innate Immune pathways, Translation, Signal Transduction, Metabolism, mRNA Regulation, Transcriptional regulation.
To apply for this position please send your CV and a cover letter to Alexei Korennykh (akorenny@Princeton.EDU) or to https://puwebp.princeton.edu/AcadHire/apply/index.xhtml (D-20-MOL-00009 | Molecular Biology | Research )
[Post Date: February 6, 2020]
Postdoctoral position to study Host-pathogen interactions
Houston Methodist Research Institute (HMRI) is a 440,000-square-foot research enterprise for Houston Methodist Hospital and is affiliated with the Weill Cornell Medical College in New York City. HMRI is a state-of-the-art laboratory facility for basic, translational and clinical research. It is located at the center of Texas Medical Center, the largest medical center in the world. The institution is surrounded by other world-renowned institutions such as Baylor College of Medicine, M.D. Anderson Cancer Center, Rice University, and University of Texas Health Sciences center.
We are seeking a microbiologist to join the group of Muthiah Kumaraswami in the Department of Pathology and Genomic Medicine. The project will seek to elucidate the role of quorum sensing pathways in host-pathogen interactions and pathogen-commensal interactions. The candidate will employ a multidisciplinary approach to dissect the mechanisms of bacterial signaling pathways and understand the contribution of such signaling pathways to bacterial pathogenesis. The fellow will use a variety of genetic, biochemical, biophysical, structural, and mouse infection methods to identify novel cellular processes involved in bacterial pathogenesis with the long-term goal of targeting these processes for antibiotic development. Some of the key areas we are currently investigating include the bacterial communication pathways, bacterial sensory systems regulating metal acquisition, and vaccine development studies.
Qualifications and Experience
Qualified candidates will have (or be about to obtain) a Ph.D. degree. The candidate is expected to have experience in basic microbiology methods, animal infection studies and preferably knowledge on protein chemistry and structure. The ability to work in a team, and good organizational and communication skills in English are also desired. Applicants should send a CV with a description of current and future research interests, representative pdfs of publications, and the names, addresses, phone numbers, and email addresses of three references to: firstname.lastname@example.org
[Post Date: February 5, 2020]
Postdoc University of Oklahoma
Postdoctoral position available immediately in Singh Group at OU.
Biochemist or Structural Biologist: Seeking a highly motivated postdoc with experience in one or more biochemical techniques involving cloning, protein expression, engineering (site-directed, site-saturation and random mutation) purification, biochemical assays, X-ray crystallography, structure calculations, and functional characterization of enzymes. The ideal applicant should have a Ph.D. in Biochemistry or related area. The candidate should have expertise in determining X-ray structures of enzymes, functional characterization, and engineering studies for their potential as biocatalysts for drug development. If you are interested in applying, please email your CV to email@example.com
Research Overview in Singh Group
Research in the Singh laboratory lies at the interface of chemistry and biochemistry. We use tools and methods from biochemistry and structural biology to characterize new enzymes from natural product biosynthetic pathways; molecular biology techniques to engineer enzymes to generate better biocatalysts; and synthetic chemistry methods for the generation of precursors necessary for natural product diversification. The fundamental goal of research in Singh laboratory is to understand and exploit natural product enzymes for developing biologically active molecules against cancer and infectious diseases. Our lab is especially interested in exploiting the ability of late stage enzymes from natural product biosynthetic pathways for the structural diversification of complex natural products. Despite the fact that structural diversification of biologically active molecules by attaching different chemical moieties has great potential to generate new drug leads, chemical methods often suffer from selectivity and tedious purification steps. Our goal is to exploit the potential of natural product enzymes and generate chemoenzymatic-tools for facile attachment of chemical moieties in a stereo- and regio- selective fashion to complex molecules towards the generation of biologically active compounds.
[Post Date: February 5, 2020]
Postdoc Brown University
The Deaconescu Lab at Brown University has one opening for a postdoctoral researcher. The laboratory's interests lie primarily in stress responses, with particular emphasis on responses to DNA damage and the mechanochemistry of DNA-based motors. We utilize a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, small-angle X-ray scattering, transmission electron microscopy). For examples of work, please see Dorich et al., Genes Dev (2019), Vemu et al. Science (2018), Le TT et al. Cell (2018), Deaconescu et al. Photochemistry and Photobiology (2017), Kutter et al. JMB (2016), Szyk et al, Cell (2014), Deaconescu et al., PNAS (2012), Szyk et al., NSMB (2012) and Deaconescu et al., TIBS (2013).
A successful candidate should have an established track-record of publications in peer-reviewed journals; solid experience with protein biochemistry (including their purification from E.coli/yeast expression, functional characterization and assay development). Prior knowledge of crystallography and/or single-particle electron microscopy is highly desirable. Must be highly motivated and work independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply.
Interested candidates should send a CV, one page research experience summary and contact information for three references to firstname.lastname@example.org. Salary and starting date are negotiable. Please write Postdoctoral Candidate in the e-mail subject header. Brown University, an Ivy League school, is located less than one hour away by train from Boston. Lab webpage: https://deaconesculab.com
[Post Date: February 5, 2020]
Postdoctoral position at Boston Children’s Hospital
A postdoctoral position is available immediately in Dr. Bing Chen’s laboratory at Boston Children’s Hospital/Harvard Medical School.
The ongoing projects include 1) biochemical and structural studies to elucidate molecular mechanisms of viral entry, 2) design and production of viral envelope-based immunogens, and 3) development of antiviral therapeutics.
For our our recent publications, please see https://connects.catalyst.harvard.edu/Profiles/display/Person/17396.
A strong background in protein biochemistry and/or structural biology is required. CryoEM expertise is a plus. We are particularly interested in those who are highly motivated and willing to tackle difficult problems. Applicants should send a cover letter, CV, and contact information of three references to Bing Chen (email@example.com).
[Post Date: February 5, 2020]