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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Staff Scientist (Structural Biology) & Research Technician (Structural Biology)

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Description:

We have two open positions in the Bhabha/Ekiert labs at NYU School of Medicine in New York City (http://bhabhaekiertlab.org). Our labs use structure-driven approaches to study bacteria, parasites, and host-pathogen interactions. In addition to these potential research areas, the candidate will also participate in structure determination efforts as part of a collaborative project with the lab of David Baker (HHMI/University of Washington; https://www.bakerlab.org).

1) a PhD-level staff scientist position for a structural biologist

2) a BS/MS-level position for technician interested in structural biology (ideal for a recent grad looking to gain more experience before applying to graduate school).

Please see the links before below for more information about the positions and how to apply.

https://jobrxiv.org/job/nyu-school-of-medicine-27778-staff-scientist-structural-biology/

https://jobrxiv.org/job/nyu-school-of-medicine-27778-research-technician-structural-biology/


[Post Date: January 22, 2021]


Postdoctoral Associate Rutgers University

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Description:

We have an immediate opening for a skilled post-doctoral researcher in the laboratory of Prof. Eddy Arnold at Rutgers University (NJ, USA).

The aim of the project is to study the structure and function of human viral proteins and polyproteins, including from HIV-1 and SARS-CoV-2, through X-ray crystallography and cryo-electron microscopy.

For more information about the position, please see the full advert: https://jobs.rutgers.edu/postings/124873

Interested candidates should apply via the above link. 


[Post Date: January 22, 2021]


Biochemist Postdoc Fellow Lawrence Berkeley Lab

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Description:

Lawrence Berkeley National Lab’s (LBNL) Biosciences Division has an opening for a Biochemist Postdoc Fellow to join the team.
 
In this exciting role, you will develop and apply biophysical and biochemical techniques to address questions relevant to understanding structural cell biology for multi-component biological macromolecules. You will aid in the characterization of biological processes.

You will be part of a team that designs, develops and applies synchrotron methods to characterize macromolecules and the assemblies they form. Primary tools will include small angle X-ray scattering (SAXS). However accessible and ancillary techniques include X-ray crystallography, cryo-electron microscopy and X-ray tomography. We seek to develop and improve overlaps with all techniques either in joint application or through software development. You will develop and maintain software for SAXS analysis or the collection of SAXS data. You will work at the Advanced Light Source synchrotron and be required to develop interdisciplinary skills to communicate with other beamline staff, engineers and physicists responsible for beamline application and development.
 
What You Will Do:
* Participate with other members of the SIBYLS team in design and implementation of instrumentation and methodology that will maximize efficient and productive data analysis from both SAXS and crystallography. This will include improving automation. Duties as part of the team will include beamline maintenance and user support.
* Publish scientific papers in peer-reviewed journals and present findings at seminars and conferences.
* Participate in the development of grant proposals for new research directions and preparation of competing renewals of current research grants.
* Maintain an accurate and detailed online laboratory notebook of all experiments performed and provide sufficient details to ensure methods and results can be duplicated by others. 
* Collaborate with program projects that utilize the beamline for research and develop new collaborations as appropriate to further the scientific goals of the SIBYLS programs.
* Cooperate with other members of the SIBYLS beamline and the Advanced Light Source division.
 
Additional Responsibilities as needed:
* Participate in professional scientific activities, e.g., reviews of papers, research proposals, etc.
* Support and contribute to the development of research project ideas and proposals.
* Participate in relevant professional societies with relevance to the program and group activities.
 
What is Required:
* Ph.D. in biology, chemistry, physics or related degree.
* Competent computer skills.
* Capacity to work with a large team of investigators.
* Ability to take detailed notes so that work could be replicated.
* Excellent written and verbal communication skills.
* Ability to work in a diverse environment.
* Experience in structural biology.
 
Desired Qualifications:
* Python programming.
* Experience in the purification of proteins.
* Work in cancer related fields.
* Work on microbial systems.
 
Notes:
* This is a full-time 1 year, postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 4 years of paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree.
* This position is represented by a union for collective bargaining purposes.
* Salary will be predetermined based on postdoctoral step rates.
* This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
* Diversity, equity, and inclusion are core values at Berkeley Lab. Our excellence can only be fully realized by faculty, students, and staff who share our commitment to these values. Successful candidates for our faculty positions will demonstrate evidence of a commitment to advancing equity and inclusion.
* Work will be primarily performed at Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA.

Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."
 
Lawrence Berkeley National Laboratory encourages applications from women, minorities, veterans, and other underrepresented groups presently considering scientific research careers.


[Post Date: January 20, 2021]


Postdoc Vanderbilt University

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Description:

An NIH-supported postdoctoral fellowship is currently available in the Mchaourab lab at Vanderbilt University in Nashville, TN. The thrust of the projects is to use biophysical approaches to investigate structure/dynamics/function in multiple classes of transporters including ABC transporters and neurotransmitter transporters. Current focus in the lab is on the application and integration of cryo-EM, EPR, transport assays, and molecular modeling. We are a highly interdisciplinary group with interest ranging from proteostasis in zebrafish to multidrug transporters. The laboratory is located in the department of Molecular Physiology and Biophysics at the school of medicine with access to state of the art cores in crystallography, cryo-EM, EPR, mass spectrometry and various biophysical instrumentation.

Candidates should have a Ph.D. in biochemistry, biophysics or related fields. Relevant skills include protein expression and purification, membrane reconstitution, biochemical analyses of function, and structure determination by x-ray crystallography or cryo-EM. Salary will be commensurate with experience and the starting date is negotiable.

If you are interested send CV and letters of recommendation to : Hassane S. Mchaourab, Ph. D., hassane.mchaourab@vanderbilt.edu

At Vanderbilt University, we are intentional about and assume accountability for fostering advancement and respect for equity, diversity, and inclusion for all students, faculty, and staff. Our commitment to diversity makes us who we are.  We have created a community that celebrates differences and lets individuality thrive. As part of this commitment, we actively value diversity in our workplace and learning environments as we seek to take advantage of the rich backgrounds and abilities of everyone. The diverse voices of Vanderbilt represent an invaluable resource for the University in its efforts to fulfill its mission and strive to be an example of excellence in higher education.

Vanderbilt University is an equal opportunity, affirmative action employer. Women, minorities, people with disabilities, and protected veterans are encouraged to apply.


[Post Date: January 20, 2021]


Postdoct Structure of Plant Hormone Transporting Membrane Proteins at Aarhus University, Denmark

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Description:

The Pedersen group at the Department of Molecular Biology and Genetics, Aarhus University, is looking for a highly skilled and motivated postdoc with an interest in working on hormone transporting membrane transporters and preferably with a proven track record in the area of structural and/or functional analysis of membrane proteins.

Starting date is negotiable. Funding is available through an ERC grant for at least 2 years of employment. 

Job description/research project/research area
The position seeks to strengthen ongoing activities in the laboratory of Bjørn P. Pedersen on structure, related to the function and mechanism of plant hormone-transporting membrane proteins as defined by the ERC project MUM-GROW (pedersenlab.dk). Exact project will be shaped out in dialogue with top runners. The laboratory's interest is the interplay between structure and function of transmembrane transport processes with a focus on metabolite uptake systems, and the methods uses are primarily crystallography and cryo-EM. The group is part of the Section of Structural Biology at Aarhus University.

Your profile
A successful candidate has a relevant Ph.D. degree and a solid and documented background in structural biology, biochemistry and/or biophysics. Experience with membrane protein expression and purification is favored, and the candidate must demonstrate an ability and interest to work with membrane proteins with a structural aim. Applicants should be ambitious, show strong collaborative skills, and be able to take initiatives and responsibility within the work environment.

Who we are/ The department
The Department of Molecular Biology and Genetics is part of the Faculty of Natural Sciences, Aarhus University and comprises research within the areas of Gene Expression, Molecular Medicine, Structural Biology, Systems Biology and Plant Molecular Biology. There are currently 75 full time scientific staff and
120 PhD students. The department is responsible for two educations: Molecular
Biology and Molecular Medicine with a yearly uptake of 160 students in total. Please refer to http://mbg.au.dk/ for further information about The Department of Molecular Biology and Genetics and to https://nat.au.dk/ and http://www.au.dk/  for information on Faculty of Natural Sciences and Aarhus University, respectively.

The successful candidate is offered:
  • Access to a well-developed research infrastructure
  • A research climate inviting lively, open and critical discussion within and across different fields of research
  • A working environment with teamwork, close working relations, network activities among young scientists and social activities
  • A workplace characterized by professionalism, equality and a healthy work-life balanceThe city
In Aarhus you have easy access to beautiful nature, an exciting culture and city life as well as a safe environment for children - a great place for the whole family. The city of Aarhus has everything you need within a surprisingly small area: exciting national and international jobs, delightful residential areas, a rich cultural life, and beautiful surrounding landscape of woods and coastline that make Aarhus a wonderful place to live and work. See here for further details on the city and the university.

Place of work
The place of work is Gustav Wieds Vej 10, Aarhus C, and the area of employment is Aarhus University with related departments. 

Contact information
For further information please contact:  Associate professor Bjørn P. Pedersen (bpp@mbg.au.dk).

Application procedure

Shortlisting is used. This means that after the deadline for applications – and with the assistance from the assessment committee chairman, and the appointment committee if necessary, – the head of department selects the candidates to be evaluated. All applicants will be notified whether or not their applications have been sent to an expert assessment committee for evaluation. The selected applicants will be informed about the composition of the committee, and each applicant is given the opportunity to comment on the part of the assessment that concerns him/her self. Once the recruitment process is completed a final letter of rejection is sent to the deselected applicants.

Letter of reference

If you want a referee to upload a letter of reference on your behalf, please state the referee’s contact information when you submit your application. We strongly recommend that you make an agreement with the person in question before you enter the referee’s contact information, and that you ensure that the referee has enough time to write the letter of reference before the application deadline. Unfortunately, it is not possible to ensure that letters of reference received after the application deadline will be taken into consideration.

Formalities and salary range

Natural Sciences refers to the Ministerial Order on the Appointment of Academic Staff at Danish Universities under the Danish Ministry of Science, Technology and Innovation.

The application must be in English and include a curriculum vitae, degree certificate, a complete list of publications, a statement of future research plans and information about research activities, teaching portfolio and verified information on previous teaching experience (if any). Guidelines for applicants can be found here.

Appointment shall be in accordance with the collective labour agreement between the Danish Ministry of Finance and the Danish Confederation of Professional Associations. Further information on qualification requirements and job content may be found in the Memorandum on Job Structure for Academic Staff at Danish Universities.

Salary depends on seniority as agreed between the Danish Ministry of Finance and the Confederation of Professional Associations.

All interested candidates are encouraged to apply, regardless of their personal background. Research activities will be evaluated in relation to actual research time. Thus, we encourage applicants to specify periods of leave without research activities, in order to be able to subtract these periods from the span of the scientific career during the evaluation of scientific productivity.

Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Read more here. Please find more information about entering and working in Denmark here.

Aarhus University also offers a Junior Researcher Development Programme targeted at career development for postdocs at AU. You can read more about it here.

The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University's website.


[Post Date: January 14, 2021]


Postdoc Berntsson Lab Umeå University

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Description:

Postdoctoral fellowship to study Type 4 Secretion System

The Berntsson lab at the department of Medical Biochemistry and Biophysics at Umeå University, Sweden, is recruiting one postdoctoral fellow (2-year fellowship, funded by the Kempe Foundation) to study the structural and functional aspects of Type 4 Secretion Systems. These large protein complexes are responsible for horizontal gene transfer between bacteria. As such, they facilitate the spread of, among other genes, antibiotic resistance between bacteria, both intra- and interspecies.

The overall goal of this project is to study the assembly and structure of the membrane channel of Gram-positive Type 4 Secretion Systems. Initial work on this project has already been done, with a focus on the individual components of the channel (see Jäger et al, 2020, bioRxiv doi: 10.1101/2020.10.30.342212), which we will now build upon. The project will involve molecular biology, biochemistry and structural biology techniques. 

Qualifications

The applicants must possess a PhD, or another diploma deemed equivalent to a PhD, within molecular biology, biochemistry, structural biology or a related field. Furthermore, the applicant must have practical experience and expertise of cloning and protein production and purification in bacteria. The applicant should preferably be experienced with (membrane) protein pull-downs and western blotting. Previous experience of working with Gram-positive bacteria, especially E. faecalis, and membrane proteins is an advantage, as is previous experience of cryo electron microscopy. The applicant must have a very good level of English, both written and spoken. The applicants are also expected to be good team players, but should also be able to work independently.

Application

The application should consist of the following:

  1. A motivation letter (max 1 A4), where you highlight why you want to join the lab and study T4SSs. This letter must also include your contact information.
  2. The Curriculum Vitae of the applicant, including a list of published peer-reviewed articles.
  3. Copies of the PhD diploma (or equivalent).
  4. Contact details for three references, of which one should be your PhD supervisor.

The duration of the fellowship is 2 years. Your application should be written in English and prepared as a single package in PDF format, to be submitted to ronnie.berntsson@umu.se. Make sure to use the subject line: “postdoc application 2021-02” in the application email. Submit the application on February 10, 2021 at the latest. The top ranked candidates will be contacted within three weeks from the closing date for an interview. Starting date according to agreement. For more information about the research or other details, please contact Dr. Ronnie Berntsson. 

Email: ronnie.berntsson@umu.se


[Post Date: January 14, 2021]


Scientist/Sr Scientist, Protein Sciences

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Description:

Overview

Civetta Therapeutics (Cambridge, MA) is recruiting a Scientist to Senior Scientist level position in Protein Sciences. Civetta is a cutting-edge biotechnology company, backed by Deerfield Management, and recently launched from the Broad Institute and Dana-Farber Cancer Institute (DFCI). Our founders, William Sellers (Broad/DFCI) and Eric Fischer (DFCI), world leaders in genomics and protein biology, launched Civetta with the mission to create a new precision medicine platform targeting “propeller” proteins.

We are building a team of talented, dedicated scientists who share our vision and our passion to discover groundbreaking new drugs to treat some of the most difficult diseases, including cancer.  If you are a talented life sciences professional who brings energy, passion, and scientific curiosity to the team, we welcome the opportunity to consider you for this important position in our growing company.

 

The position.  We are seeking an experienced and creative protein biochemist at the Scientist to Senior Scientist level to propel our gene-to-structure (G2S) efforts in Protein Sciences, helping to build world-class platform capabilities in discovering small molecule modulators of beta-propeller proteins, supporting biological discovery and our drug development programs.  

Responsibilities

Key Responsibilities

  • Provide expertise and insight for construct design and purification protocols for protein production.
  • Perform purification of challenging beta-propeller proteins to establish robust protocols that can be used internally or transferred to external (CRO) resources as needed.
  • Specify and procure necessary equipment, enabling technologies and reagents.
  • Collaborate productively with biochemistry and biophysics colleagues to source protein reagents for assay development targeting beta-propeller proteins and multi-protein complexes.
  • Make intellectual contributions to all stages of drug discovery and project delivery.

Qualifications

Qualifications

  • Ph.D. degree in biochemistry, structural biology or related discipline with 5+ years of industry experience or Master’s/Bachelor’s degree with 10+ years of experience.
  • Extensive protein biochemistry experience working with challenging proteins and multi-protein complexes.
  • Experience using specialized purification strategies, such as HIC and protein refolding.
  • Knowledge of protein structure and experience in the preparation of high-quality, concentrated protein samples for biophysical (SPR, ITC, DSF) and structural studies (NMR, X-ray, Cryo-EM).
  • Experience balancing CRO and internal resources to solve problems and drive progress.
  • Exceptional interpersonal and communication skills, and ability to effectively present data within the company and to other stakeholders.

Adept at working effectively within motivated cross-functional scientific teams to deliver project goals within timelines.

 

Civetta Therapeutics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

 

Notice to Third-Party Recruiters/Staffing Agencies: Recruitment is managed through Civetta Therapeutics’ Human Resources department. Resumes will only be accepted from staffing agency/recruiters if there is a signed contract in place. Recruiters are requested to not contact our hiring managers or employees directly to inquire about open positions or to present candidates. In the event a staffing agency/third-party recruiter submits a resume without a contract in place, the candidate submitted will be considered unsolicited and treated as if the candidate submitted their resume directly to Civetta, and no fee/payment will be paid. Recruiters interested in working with Civetta Therapeutics can submit their information to contact@civettatherapeutics.com, and we will contact you if needed.


[Post Date: January 14, 2021]


Senior Technician Position Biochemistry and Structural Biology Unit - IEO Milano

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Description:

A position is open at the Biochemistry and Structural Biology Unit of the European Institute of Oncology in Milan.

The Unit (https://www.research.ieo.it/research-and-technology/technological-units/biochemistry-and-structural-biology-unit/) is one of the technological platforms of the Department of Experimental Oncology of the European Institute of Oncology (www.research.ieo.it), a comprehensive cancer centre located in the south area of Milan.

We provide services and support to the department in the fields of Biochemistry and Structural Biology and collaborate both with scientific groups of the department and external ones to foster the structural biology aspects of their projects.

The ideal candidate has a Master/PhD degree in Chemistry, Biotechnology or Biology, with strong interest in biochemistry and structural biology. We are looking for an enthusiastic, motivated person, with good organisational and relational skills, and a good knowledge of English.

She/he will take care of assisting scientists collaborating with the Unit in macromolecular samples purification, characterisation and crystallisation, managing sample shipment to synchrotrons, supervising instrumentation usage and maintenance.

The Unit is setting up a Cryo-EM lab with an in-house VitroBot blotting device and external Electron Microscopy access, which the candidate is expected to manage. Experience in setting up grids and Cryo-EM data collection will be a distinguishing skill.

Potential applicants are encouraged to contact Dr. Sebastiano Pasqualato, sending a brief description of interests, and a CV with at least one referee contact to sebastiano.pasqualato@ieo.it.


[Post Date: January 11, 2021]


Postdoc Membrane Protein Structural Biology Case Western Reserve University

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Description:

The laboratory of Nami Tajima at Case Western Reserve University School of Medicine seeks a highly motivated and creative individual with expertise in structural biology and molecular neuroscience/electrophysiology to elucidate the molecular mechanism of ligand-gated ion channel signaling complexes.

Our research interests are focused on 
1. understanding the regulatory mechanisms of ion channels involved in basic brain functions and neurological diseases
2. dissecting the signaling networks/ protein-protein interactions in the context of synaptic signaling
3. structure-based drug discovery

These issues will be addressed using a multidisciplinary approach that includes Cryo-EM, X-ray crystallography, electrophysiology, molecular and cellular biology, and biochemistry/biophysics. Case Western Reserve University is equipped with a state-of-art structural biology facility, including screening microscopes, and a Titan Krios with a K3 camera.

The successful candidate for the postdoctoral researcher must have a recent Ph.D. obtained within three years (or being in the process of completing one) in a relevant field with a demonstrated track record of productive research. Expertise in one or more of the following areas; biochemistry, biophysics, protein expression and purification, cryo-EM, X-ray crystallography, electrophysiology, neuroscience, cell biology, mass spectrometry, and invitro and in vivo fluorescence imaging. Interested applicants should submit (1) a cover letter describing research interests and career goals; (2) a CV; and (3) contact information for 2-3 references by email to Nami Tajima at nxt193@case.edu.

Follow the link for more details:
https://sites.google.com/case.edu/tajimalab/home
https://physiology.case.edu/people/faculty/nami-tajima/


[Post Date: January 11, 2021]


Postdoctoral Researchers, Membrane Structural and Functional Biology, Trinity College Dublin and University of Dundee

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Description:

Post Summary

The cation channel formed by the envelope protein in SARS-CoV2, CoV2E, is a target for therapeutics aimed at preventing and treating Covid-19 infection.

The goal of the current project is to i) solve high-resolution crystal structures of CoV2E, ii) apply computational electrophysiology and in silico screens including cheminformatics/machine learning approaches to identify CoV2E inhibitors from libraries of commercially available and repurposing drugs, and iii) perform lead validation and further development of inhibitors by electrophysiology and crystallography.

The project, funded by the UKRI (Ideas to Address COVID-19), will be performed by three Postdoctoral Research Fellows in the laboratories of Prof. Martin Caffrey (X-ray crystallography, Trinity College Dublin), Dr. Samantha Pitt (electrophysiology, University of St. Andrews) and Prof. Ulrich Zachariae (computational biology, University of Dundee).

Exciting postdoctoral research positions are available in the Caffrey and Zachariae Groups at this stage. We are looking for highly motivated, creative and hardworking individuals with experience in biochemistry and molecular biology to join this multidisciplinary research programme in labs that offer superb facilities and supportive environments. Individuals interested in moving into the membrane protein field are encouraged to apply.

The home department for successful applicants will be the University of Dundee. The successful applicant for the position in the Caffrey lab will hold their appointment through the University of Dundee and will work full-time at Trinity College Dublin.

Person Specification

Caffrey Lab Position The candidate will ideally have a Ph.D. in biochemistry, biophysics, molecular biology or a related field. Demonstrated success in all aspects of molecular biology, recombinant protein production, purification, and functional characterization is required. Experience with membrane protein over-expression, crystallization, and structure-function studies is desirable. The candidate should be a highly motivated and creative individual who enjoys working as part of a collaborative, multidisciplinary team. Strong leadership, communication and teaching skills are decided assets. A willingness and freedom to travel worldwide on short-term projects is expected.

Zachariae Lab Position The candidate will ideally have a Ph.D. in biophysics, biochemistry, chemistry or a related field and experience in molecular dynamics simulations or computational chemistry. Further experience and interest in computational drug design is desirable. The candidate should be proficient in Python or similar scripting/programming languages. A high degree of motivation and the willingness to work in an interdisciplinary environment are expected.

Principal Investigators

Prof. M. Caffrey https://www.tcd.ie/Biochemistry/research/caffrey/

Dr. S. Pitt https://synergy.st-andrews.ac.uk/metalion/ 

Prof. U. Zachariae https://www.lifesci.dundee.ac.uk/groups/ulrich_zachariae/index.html

Application Procedure Candidates are asked to submit a letter detailing education, training and laboratory experience. In the letter, the candidate should outline why they feel they are suitable for the position in an interdisciplinary group that will involve extensive interaction with collaborators and data collection at facilities around the globe. The letter of application must be accompanied by a comprehensive CV to include the names and contact details of two referees (email addresses and phone numbers to be provided). At least one referee should be an individual the candidate has worked with and who has agreed to provide a letter of reference on the candidate’s behalf.

Please indicate in your letter which position you are interested in.

Salary Grade 7 Salary Scale, £32,817 - £34,804 per annum depending on experience

Appointment as a Postdoctoral Research Fellow on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. In this case the initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £31,866).

Use the following link to submit your application: https://www.jobs.dundee.ac.uk/fe/tpl_uod01.asp?s=4A515F4E5A565B1A&jobid=104594,9348658758&key=148828089&c=02479972238776&pagestamp=secbhmrsxvcorurlem


[Post Date: January 11, 2021]


Postdoc RNA Processing Columbia University

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Description:

A Post-doctoral Research Associate position is available in the Liang Tong Lab for structural studies on proteins involved in RNA processing and quality control, using cryo-EM and crystallography. We have extensive experience in these areas, and have generated many high-impact publications (for example Science, 367, 700, 2020; Mol. Cell, 77, 800, 2020). Please see our home page for more information-

http://tonglab.biology.columbia.edu/

Strong experience in protein biochemistry is required. Prior experience with cryo-EM and/or X-ray crystallography is desirable.  Please send CV and names of three references to ltong@columbia.edu.


[Post Date: January 11, 2021]


Postdoc ICTER in Warsaw, Poland

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Description:

In the Integrated Structural Biology laboratory at The International Center for Translational Eye Research (ICTER) in Warsaw, Poland, one postdoctoral position is available for highly motivated biologists, biochemists, or structural biologists, for 34 months (maximum planned period of contract: 31/12/2023). The position involves cloning, protein production, purification, characterization, and structural elucidation of proteins from the visual cycle.

 For details, and how to apply until 31st January, see:

https://ichf.edu.pl/en/job/mcbo-33-2021


[Post Date: January 6, 2021]


Postdoc KU Leuven, Ligand-gated Ion Channels

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Description:

A post-doctoral position is available at the Laboratory of Prof. Chris Ulens, KU Leuven, Belgium (http://www.xtal.be). The research in the Laboratory of Structural Neurobiology is aimed at understanding the molecular mechanism of ligand-gated ion channels. Our methods rely on X-ray crystallography and cryo-EM in combination with electrophysiological recordings and fluorescence-based techniques. Our laboratory hosts an integrated macromolecular crystallization facility with a Mosquito crystallization robot and two RockImagers. We have access to a 200 kV Glacios microscope on campus as well as 300 kV JEOL CryoARM300 at the nearby EM facility in Brussels. Current projects are situated at the crossroads of structural elucidation and drug discovery of different pentameric ligand-gated ion channels.

We would like to recruit a post-doc with prior experience in cryo-EM or X-ray crystallography of membrane proteins.

The successful candidate:

- easily communicates in an open verbal manner and has a team player spirit

- has an ambitious work ethic

- critically contributes to writing of manuscripts and grant proposals

- makes efforts to obtain independent funding

- meets intermediate deadlines and brings projects to a successful end

- fuels internal discussions of recent publications in the field

- sets an example to younger PhD students in the lab

- identifies directions for future scientific research

The position is open immediately and applications will be accepted until the position is filled. Applicants are requested to submit a CV with publication list and two references. E-mail to chris.ulens@kuleuven.be

Selection of recent publications:

A lipid site shapes the agonist response of a pentameric ligand-gated ion channel. Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan G, Nury H, Steyaert J, Baenziger JE, Ulens C. Nat Chem Biol. 2019;15(12):1156-1164. doi: 10.1038/s41589-019-0369-4.


[Post Date: January 5, 2021]


Postdoc ENS Paris-Saclay FRANCE

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Description:

3-year Post-doctoral position in the Cherfils lab, ENS Paris-Saclay France

The group: The Structural Biology of Small GTPases group has a long-standing expertise in the biochemistry and structural biology of Ras-like small GTPases. Our aim is to understand the molecular reactions that govern the functions of small GTPases in cellular traffic and cytoskeleton dynamics in normal cells and in diseases, and to apply this knowledge to establish new concepts in drug discovery. Our team is located in the multidisciplinary environment of the new Ecole Normale Supérieure Paris-Saclay Campus, which is easily accessible from Paris by public transportation.

The project: This project aims at understanding the collective behavior of small GTPases and their regulators as they assemble signaling modules at the surface of membranes. It combines structural biology, reconstitution of macromolecular complexes in artificial membranes, activity analysis using biophysical methods, and imaging using TIRF microscopy. The project offers a variety of integrative structural biology approaches and benefits from established collaborations.

The candidate: We are looking for a highly motivated post-doctoral fellow with a strong background in protein biochemistry. Experience in protein-membrane interaction methods, TIRF and/or structural biology will be a plus. The candidate should have good communication skills and appreciate teamwork.

The position: The position is funded for 3 years by the ANR and the Fondation pour la Recherche Médicale and is available immediately.

For application, please contact:

Agata Nawrotek Maalouf agata.maalouf@ens-paris-saclay.fr Jacqueline Cherfils jacqueline.cherfils@ens-paris-saclay.fr

 


[Post Date: January 5, 2021]


Senior Crystallography Scientist

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Description:

Evotec (UK) Ltd is currently seeking to add to its Structural Biology Department. The group works closely with our Discovery Chemistry Department and with clients to develop novel small molecule drugs. Our team is at the forefront of new science and technology, and is seeking to expand as business needs grow.

Required knowledge, skills and abilities:

  • Extensive knowledge in protein biochemistry and macromolecular crystallography
  • Experience with protein purification
  • Familiar with protein engineering, bioinformatics and molecular biology (Construct design and cloning strategy)
  • Familiar with Biophysic techniques (DSF, ITC…)
  • The successful candidate will have experience working in multi-disciplinary teams
  • Experience collaborating with scientists in external organisations

Responsibilities includes:

  • Reading scientific literature relevant to the project
  • Supporting a project team by designing and ordering constructs to initiate the project
  • Adapting scientific knowledge to resolve problems encountered in achieving defined goals with assistance from line manager or other team members to meet internal and project deadlines
  • Preparing reports, presenting data, and collaborating with other scientists at Evotec
  • Presenting own work at project technical meetings, and department technical meetings when required
  • Demonstrating full command of all techniques and tools required for assigned responsibilities within the given project
  • Ensuring safe working practices of themselves and any direct reports
  • Complying fully with the company safety policy (including COPs and SOPs) when performing experiments
  • Adhering to Lab Notebook guidelines regarding accurate documentation of lab experiments

Desirable Knowledge, Skills and Abilities:

  • Self-motivated, enthusiastic, cooperative and reliable
  • Knowledge of basic laboratory techniques, and understanding of the science underlying the techniques and experiments
  • Experience of working in a lab environment
  • The ability to adapt to changing demands whilst operating under pressure to deadlines
  • The ability to work accurately and with attention to detail
  • Good interpersonal skills and the ability to work well with other scientific staff
  • The ability to work well independently, and as part of a team
  • Good organisational and time management skills
  • Good verbal communication skills
  • Ability to maintain excellent laboratory records
  • Computer proficiency

Education & Experience:

  • PhD degree or equivalent in Structural Biology, Biochemistry or related area


[Post Date: December 22, 2020]


Postdoctoral Researcher, Membrane Structural and Functional Biology, Caffrey Lab, Trinity College Dublin, Ireland

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Description:

Post Summary  The Membrane Structural and Functional Biology group seeks to solve the structure of medically important membrane proteins for use in structure/function studies and for structure-based therapeutics development. Target proteins are involved in communicable and non-communicable diseases.

An exciting postdoctoral research position is available in the Group. We are looking for a highly motivated, creative and hardworking individual with experience in biochemistry and molecular biology to join our multidisciplinary team at Trinity in a lab that offers superb facilities and a supportive environment. Individuals interested in moving into the membrane protein field are encouraged to apply.

Person Specification  The candidate must have a Ph.D. in biochemistry, biophysics, molecular biology or a related field. Demonstrated success in all aspects of molecular biology, recombinant protein production, purification, and functional characterization is required. Experience with membrane protein over-expression, crystallization, and structure-function studies is desirable. The candidate should be a highly motivated and creative individual who enjoys working as part of a collaborative, multidisciplinary team. Strong leadership, communication and teaching skills are decided assets. A willingness and freedom to travel worldwide on short-term projects is expected. 

Salary  €38,631 - €45,942 per annum depending on experience

Closing Date  Until the position is filled

Principal Investigator Prof. Martin Caffrey https://www.tcd.ie/Biochemistry/research/caffrey/  

Application Procedure  Candidates are asked to submit a letter detailing education, training and laboratory experience. In the letter, the candidate should outline why they feel they are suitable for the position in an interdisciplinary group that will involve extensive interaction with collaborators and data collection at facilities around the globe. The letter of application must be accompanied by a comprehensive CV to include the names and contact details of two referees (email addresses and phone numbers to be provided). At least one referee should be an individual the candidate has worked with and who has agreed to provide a letter of reference on the candidate’s behalf. The letter and CV should be combined in a single PDF.

Applications should be emailed to: msfb789@gmail.com  


[Post Date: December 21, 2020]


Postdoc Structural Biology, Paris-Saclay University

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Description:

A post-doctoral position in structural biology is available at the ChemSyBio team (Paris-Saclay University, INRAE, Micalis) headed by Dr Olivier Berteau. The project involves structure determination of novel metalloenzymes by X-ray crystallography, with a focus on enzymes catalyzing peptides (RiPPs) post-translational modifications. Our goal is to decipher the mechanism and mode of interactions between these enzymes and their substrate.

We are seeking for a highly motivated post-doctoral fellow with a proven experience in X-ray crystallography. The candidate should have a PhD in structural biology and a good knowledge of crystallography software.

He/She should have an experience in protein expression, purification, crystallization and the ability to work in a multi-disciplinary environment. Skills in molecular biology and physico-chemical techniques would be an asset.

Recent publications from our team include: Balty et al., 2020 JBC; Balty C et al. 2019 JBC; 294(40):14512-14525; Parent A. et al. 2018 J Am Chem Soc. ; 140(7):2469-2477.; Benjdia A et al. 2017 Nature Chemistry ; 9(7):698-707;  Parent A. et al. 2016 J Am Chem Soc.; 138(48):15515-15518;  Benjdia A. et al.2016 Chem Commun.; 52(37):6249-52; Benjdia A. et al. 2015 Nat Commun; 6:8377.

Access to state-of-the-art research facilities will be provided. Our laboratory (Micalis institute) is part of Paris-Saclay University and located near Paris. The position is offered for one-year, renewable up to 3 years. The salary will be commensurate with experience.

Applications (including CV, description of your research activity indicating your relevant skills and reference letters) should be sent to Dr Alhosna Benjdia (alhosna.benjdia@inrae.fr) and Dr Olivier Berteau (olivier.berteau@inrae.fr).


[Post Date: December 21, 2020]


Tenure Track Faculty position at UMass Medical School

View the Job Posting Here

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Description:

The Department of Biochemistry & Molecular Pharmacology at the University of Massachusetts Medical School seeks applicants for a tenured or tenure track faculty position in biochemistry. With research programs spanning a broad range of subjects, our faculty is committed to tackling fundamental biological questions at a molecular level. We are an interactive group that encourages the development of enabling technologies, research at the interface of multiple disciplines, and team science. More information about the department can be found on our website (https://www.umassmed.edu/bmp).

We are searching for a highly motivated and enthusiastic individual, committed to diversity, creativity, and collaboration, to join our team of active engaged faculty. The successful candidate will develop and lead an internationally-recognized extramurally-funded research program, contribute to our missions of education and service, and play an active role in the Department as we expand in a new phase of growth. Qualified applicants will have earned a Ph.D. in a life or physical science discipline and have a demonstrated track record of outstanding accomplishment. Applicants of all academic ranks with a strong commitment to enhancing diversity and inclusivity are encouraged to apply.

The Department is housed on two floors of a well-appointed 340,000 sq ft research building on a rapidly expanding Medical School campus. Core facilities for cryo-electron microscopy, X-ray crystallography, NMR spectroscopy, small molecule screening, structure-based drug design, mass spectrometry, proteomics, genotyping, fluorescence-activated cell sorting, microscopy/imaging, deep sequencing, genomics/bioinformatics, transgenic/knockout mice, and metabolic phenotyping are available. More information about these and other core facilities may be found here: https://www.umassmed.edu/research/cores/.

The University of Massachusetts Medical School is a world-class public research institution located in the heart of New England. Worcester is the second largest city in the Commonwealth, providing a rich and diverse environment with thriving art, music, and cultural scenes. Worcester is also nestled in the center of New England farm country, providing the opportunity to enjoy a myriad of outdoor activities within minutes of the campus. The major travel hubs of Boston and Providence are within 50 miles of campus.

Applicants should submit a cover letter, curriculum vitae, statement of research interests, diversity statement, and contact information for three references to http://www.academicjobsonline.org. Inquiries, but not application materials, should be directed to the Chair of the Faculty Search Committee, Dr. Sean Ryder (sean.ryder@umassmed.edu). Evaluation of applications will begin as soon as they are received, and will continue until the position is filled.

UMass Medical School is committed to being an equal opportunity and affirmative action employer and recognizes the power of a diverse community. We encourage applications from protected veterans, individuals with disabilities and those with varied experiences, perspectives and backgrounds to consider UMass Medical School as their employer of choice.

As an equal opportunity and affirmative action employer, UMMS recognizes the power of a diverse community and encourages applications from individuals with varied experiences, perspectives and backgrounds.


[Post Date: December 16, 2020]


Engineer, Center for Structural Biology (CBS), CNRS-INSERM-University of Montpellier

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Description:

Missions
The Engineer will work within the Center for Structural Biology (CBS), CNRS-INSERM-University of Montpellier, in William Bourguet team in Montpellier. He (she) will participate in research projects focused on the mechanisms involved in the (de)regulation of nuclear receptor signaling. He (she) will implement, within the framework of established protocols, the techniques of molecular biology (cloning), biochemistry (protein purification), biophysical characterization of protein samples and protein crystallization.


Place of work
The Center for Structural Biology (CBS) is a CNRS-INSERM-University of Montpellier joint research unit with a fundamental and multidisciplinary vocation. The general objective of CBS is to conduct cutting-edge research in structural biology, biophysics and bioengineering in order to describe and understand the physico-chemical mechanisms underlying biological processes, from the molecular and cellular level to supramolecular assemblies in the context of living organisms. This knowledge is used to develop new tools for research or to design new diagnostic or therapeutic strategies with applications in human health.
The CBS currently hosts around a hundred people (researchers, assistant professors and professors, engineers, post-docs and PhD students) divided into 12 teams organized into two departments: the Department of Structural Biology and the Department of Biophysics and Bio-Engineering. The diversity of techniques and expertise present on the same site, as well as the solid network of local, national and international collaborations, allow the CBS to carry out increasingly ambitious scientific projects by integrated and multi-scale approaches which cross the barriers between biology, chemistry, physics and mathematics. CBS contributes to training through research by welcoming many interns, doctoral students and post-docs of all nationalities.


Position
Our laboratory has strong interest in studying structure-function relationship of different therapeutic and environmental targets and their interaction with ligands (natural molecules, pharmaceutical drugs and endocrine disruptor compounds). We wish to recruit an Engineer who will participate in projects aimed at structurally studying nuclear receptor macromolecular complexes. The candidate will have to master classical molecular biology techniques (DNA purification, PCR, cloning, mutagenesis, bacterial and mammalian cultures), protein purification techniques (AKTA system), biophysical characterization assays (DLS, CD, SEC-MALS among others), and protein crystallization (using automation). Experience with cryo-EM grid preparation and negative staining would be a plus. The position is to be filled for an initial period of 3 months and could be extended for 18 months. Proficiency in office software (Word, Excel, PowerPoint) and GraphPad or Origin is required.

Qualifications

The desired level of education of the candidate should be a 3-year university degree. In addition, the candidate must justify of at least 2 years of professional experience in preparation and biophysical characterization of protein samples and/or protein crystallization. He (she) must be a motivated and reliable person, have a good ability to adapt to new techniques, the ability to perform meticulous and rigorous work, to work in a team, to analyze and present experimental results and to have a sense of organization.

Contact

The expected date of employment is 1st March 2021. The research team concerned by this recruitment is that of William Bourguet (http://www.cbs.cnrs.fr/index.php/en/home-equipea5). The candidate will be supervised by William Bourguet and Albane le Maire and will actively participate in the scientific life of the team. The candidate can submit a curriculum vitae and the contact details of two referees to Albane le Maire email: albane.lemaire@cbs.cnrs.fr

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[Post Date: December 16, 2020]


Postdoc Protein Biophysics & Structural Biology, Buck Lab, Case Western Reserve University Medical School, Cleveland, Ohio, USA

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Description:

We are looking to add postdoctoral co-workers to our interdisciplinary team as new funding has been awarded to our laboratory for the investigation of the role of Plexin in interacting with kinases and Alzheimer proteins, as well as several other systems (an IDP, a peripheral membrane protein and an enzyme) in collaboration with leading local laboratories. Our interest is to understand the disease associated protein interactions at the protein biophysics, biochemical, structural and protein dynamics level. 

We are looking for talented and highly motivated coworkers, who aim to become independent researchers/project leaders (> ½ of the previous postdocs accomplished this goal). Prior experience with protein purification is a must and with structural biology (protein NMR, EPR, x-ray crystallography and/or cryo-EM) is highly desirable. Cleveland is well equipped with cryo-EM (Titan Krios) and NMR spectrometers (600,700,800 & 900 MHz). The Buck laboratory provides a stimulating but friendly working environment. The Medical School of Case Western Reserve University is highly rated overall in the US (~ 16th. in terms of NIH funding for 2020) and Cleveland is a pleasant but affordable place to live with excellent educational, medical and cultural institutions. The starting date is as soon as possible but this project details are negotiable and the salary is competitive, based on experience. Please send your resume, overview of your scientific interests and career goals as well as contact details of three referees able to provide references by e-mail to matthias.buck@case.edu


[Post Date: December 16, 2020]


Postdoc Félix REY team at the Institut Pasteur in Paris, France

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Description:

We are looking for a postdoc with background in Protein Biochemistry and Structural Biology to join our team at the Institut Pasteur in Paris, France. We study human viruses, trying to answer fundamental questions related to viral entry, membrane fusion and virus-host interactions – in particular with cellular receptors and the immune system. We use a panel of approaches, primarily structural biology techniques (X-ray crystallography and cryo-EM) combined with biophysics and functional characterizations.

The candidate must have some experience in recombinant protein expression and purification, and / or structural biology methods. Knowledge of cellular biology and hands-on experience with membrane proteins is a plus but is not necessary. Most importantly, the candidate needs to be resourceful, driven, and with a desire to learn new things and work in a team. 

Start date negotiable.

Please send your CV to marija@pasteur.fr when contacting us.

For more about postdoc life in Paris and at Institut Pasteur http://stapa.ovh/

Follow us at https://twitter.com/virusfusion007


[Post Date: December 14, 2020]


Postdoc Positions Baylor College of Medicine

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Description:

Two postdoctoral positions are available in the laboratory of Dr. Pengxiang Huang, Assistant Professor and CPRIT scholar in cancer research in the Department of Molecular and Cellular Biology at Baylor College of Medicine. With the long-standing interest in sterol lipids, the Huang lab investigates the poorly understood mechanisms involved in Hedgehog (Hh) and Wnt signal transduction, two related pathways that play critical roles in development, regeneration and cancer. We utilize a combination of biochemistry, cell, chemical and structural biology approaches, including both X-ray crystallography and Cryo-EM. Our recent work identified cholesterol as the endogenous ligand for Smoothened, the key signal transduer and oncoprotein in the Hh pathway (Cell. 166:1176-87). We also characterized the structural and oncogenic basis of Smoothened activation, demonstrating for the first time the active conformation of a class F GPCR (Cell. 174:312-24). The highly interdisciplinary and collaborative environment of our group will thus provide unique career development opportunities for future postdoctoral trainees.

We are seeking highly-motivated candidates with a Ph.D. in biomedical sciences and significant experience in molecular biology, protein biochemistry and/or cell biology. Prior knowledge in structural biology (X-ray crystallography or Cryo-EM) is highly desirable, but not required. Candidates should have a documented publication record in peer-reviewed journals, able to work both independently and as an effective team member.

To apply, please send your CV, a short summary of research experience, and three reference letters to cnssolve[at]gmail.com.


[Post Date: December 14, 2020]


Scientist I – Structural Biology Frederick National Laboratory for Cancer Research

View the Job Posting Here

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Description:

Job ID: req1460
Employee Type: exempt full-time
Facility: ATRF: Other
Location: 8560 Progress Drive, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public’s interest.  

 Position Overview:

PROGRAM DESCRIPTION

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

KEY ROLES/RESPONSIBILITIES

Scientist I – Structural Biology

  • The candidate will join the structural biology group within the RAS initiative and will be responsible for the crystallization and the structure determination of protein-small molecule and protein-protein complexes by X-ray crystallography and cryoEM
  • The work will include construct design, biochemical and biophysical characterization, crystallization, X-ray data collection, structure determination, and analysis
  • The candidate will work closely with protein scientists, biophysicists, and protein NMR scientists as part of an integrated structural biology effort
  • The candidate will be a member of the drug discovery team, working closely with computational and medicinal chemists on structure-based drug design approaches for small molecule agent optimization. The candidate will be expected to be able to participate in experimental design and to conduct experiments in a priority-driven environment independently
  • The candidate will be responsible for completing projects independently and as part of a team and will be responsible for timely updates of the project progress to their supervisor both informally and by formal report writing
  • Work requires the use of personal protective equipment and adherence to strict safety protocols

BASIC QUALIFICATIONS

  • Possession of a PhD degree in structural biology, protein biochemistry/biophysics, crystallography, or in a related discipline from an accredited college or university, according to the Council for Higher Education Accreditation
  • Proven ability in all aspects of protein crystallography from construct design through structure determination and analysis
  • Experience in the crystallization of protein-small molecule and protein-protein complexes
  • Expertise in commonly used structural biology software packages
  • Proficiency in protein biochemical and biophysical assays
  • Excellent communication and witting skills
  • Detail-oriented, highly organized and able to manage multiple tasks and deliver quality data
  • Must be able to obtain and maintain a clearance

PREFERRED QUALIFICATIONS

  • Experience in analyzing protein small-molecule interaction using isothermal titration calorimetry (ITC), differential scanning fluorimetry (DSF), and NMR techniques
  • Knowledge of mechanistic enzymology, and protein chemistry
  • Knowledge of cryoEM workflow

JOB HAZARDS

  • This position is subject to working with radioactive material and requires to become an approved radiation worker

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)


[Post Date: December 11, 2020]


Postdoc Brown University, USA

View the Job Posting Here

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Description:

The Deaconescu Lab at Brown University has one opening for a postdoctoral researcher. The laboratory's interests lie primarily in stress responses, with particular emphasis on responses to stress, DNA damage and the mechanochemistry of DNA-based motors. We utilize a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, transmission electron microscopy). Examples of work are: Brugger et al, Nature Communications (2020), Dorich et al, Genes & Development (2019), Vemu et al. Science (2018), Le TT et al. Cell (2018), Deaconescu et al. Photochemistry and Photobiology (2017), Kutter et al. JMB (2016), Szyk et al, Cell (2014), Deaconescu et al., PNAS (2012), Szyk et al., NSMB (2012) and Deaconescu et al., TIBS (2013) and Deaconescu et al., Cell (2006).

 A successful candidate should have an established track-record of publications in peer-reviewed journals; solid experience with protein biochemistry (including their purification from E.coli/yeast,  functional characterization and assay development).  Prior knowledge of crystallography and/or single-particle electron microscopy is highly desirable, but not required. Must be highly motivated and work well independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply. We have a variety of projects available at different stages of development.

Interested candidates should send a CV, a one page research experience summary and contact information for three references to alexandra_deaconescu[at]brown.edu. Please use “postdoctoral candidate” as a subject.

Salary and starting date are negotiable.   Please write Postdoctoral Candidate in the e-mail subject header.   Brown University, an Ivy League school, is located in Providence, Rhode Island less than one hour away by train from Boston.   Rhode Island provides plenty of opportunities for outdoor recreation with beautiful beaches and sailing.

Lab webpage: https://deaconesculab.com


[Post Date: December 10, 2020]


Postdoc in Therapeutics Discovery Division at MD Anderson Cancer Center

View the Job Posting Here

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Description:

A postdoctoral position is currently available in the Structural Chemistry group, part of the Institute for Applied Cancer Science (IACS) within the Therapeutics Discovery Division of MD Anderson Cancer Center. Our mission is to integrate novel biological insights with drug discovery expertise to accelerate the development of innovative, targeted, small-molecule therapeutics for unmet medical needs. Our work is conducted in a team science environment that brings together excellence in both academic and pharmaceutical discovery, as evidenced by recent publications.

We are seeking a highly motivated individual with a strong background in structural biology, including protein expression and purification, protein crystallization, and X-ray crystallography structure determination. Experience with cryo-EM structure determination and/or structure determination of membrane proteins is not required, but would be advantageous. We are seeking only the most dedicated individuals who will join us in our quest to discover, develop and deliver more effective treatments to our patients. This is a unique opportunity to participate in project-driven drug discovery research within a highly respected academic and clinical setting.

Interested individuals should apply via the Postdoc Jobs website. 

https://www.postdocjobs.com/posting/7072972


[Post Date: December 10, 2020]


Genentech Postdoctoral Fellowship – Structural Biology, Matsumoto Lab

View the Job Posting Here

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Description:

The Matsumoto Lab, within the Structural Biology Department at Genentech, is seeking an innovative Postdoctoral Fellow to pursue engineering and structural characterization of immunoglobulins and their interactions with various cellular receptors and antigens. The Postdoctoral Fellow will use protein engineering paired with X-ray crystallography and/or cryo-electron microscopy (cryo-EM) to explore various immunoglobulin formats for technology development and potential therapeutic applications. He/she will structurally characterize complexes of immunoglobulins with their receptors to elucidate the molecular mechanisms of recognition and understand structure-function relationships. The successful candidate will spearhead all aspects of his/her projects including antibody engineering, protein purification, biophysical characterization, and structure determination. Our department has state-of-the-art crystallography and cryo-EM facilities along with directed evolution platforms for protein engineering. This is a unique Postdoctoral Fellowship opportunity to pursue cutting-edge technology development and publication-oriented basic research in a highly collaborative, industrial setting.

The successful candidate will be a highly motivated and detail-oriented researcher, driven to solve complex scientific problems, and able to work both independently and in a collaborative environment. Strong oral and written communication skills are required. Candidates must have a Ph.D. in structural biology, biochemistry, molecular biology, or a related field. Expertise in protein purification, biophysical characterization, and structure determination by X-ray crystallography and/or single-particle cryo-EM is required, as evidenced by a strong record of first-author publications in top peer-reviewed journals. Experience in protein engineering and directed evolution techniques, such as phage display, along with biophysical characterization methods for protein-protein interactions, such as surface-plasmon resonance (SPR) or bio-layer interferometry (BLI), are a plus.

For more information on the Matsumoto Lab, please visit: https://www.gene.com/scientists/our-scientists/marissa-matsumoto

For more information on the Genentech Postdoctoral Program, please visit: http://www.gene.com/careers/academic-programs/postdocs

Interested applicants should apply here: 

https://www.gene.com/careers/detail/202010-127016/Postdoctoral-Fellow-Oe-Structural-Biology-Matsumoto-Lab

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[Post Date: December 8, 2020]


Postdoc Washington University in St. Louis

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Description:

A postdoc position is immediately available for a highly motivated individual to study membrane enzymes, transporters and adhesion molecules that are important therapeutic targets in hematology and cardiovascular biology. To support the study, Dr. Weikai Li’s lab at Washington University in St. Louis has developed unique multidisciplinary approaches that combine novel structural biology and mass spectrometry methods with biochemistry and cell biology. Recent publications of the lab include those in Science, Science Adv., EMBO J and NSMB. The lab is well funded by five grants from NIH and other foundations, which can support the entire duration of postdoctoral study. More information of the lab can be found at https://weikailab.wustl.edu.


Requirements and Responsibilities
The postdoc candidate should have strong background and publication record in structural biology and biochemistry. The postdoc will have a unique opportunity to work on cryo-EM and crystal structures of membrane proteins, study their biochemistry, and combine with mass spectrometry to elucidate their native states and interactions. This combination will greatly benefit the future career of the postdoc Previous trainees have obtained professorship and funding at top universities.
Current projects in the lab include:


• Cryo-EM and crystal structures of several membrane proteins and complexes important in hematology and cardiovascular biology.
• Development of Cryo-EM methods to readily solve structures of most membrane proteins.
• The cellular interactions of tetraspanins that regulate B cell trafficking.
• The cellular organization of tight junction formation mediated by claudins and associated molecules.


Furthermore, the lab culture encourages free exploration, and the fellow is welcome to develop their own research projects and strategies that are of mutual interest. High degrees of motivation and independency are greatly appreciated. On the other hand, the PI is always available to provide advices.
Research Environment: The Washington University Medical School ranks top 5 in the US. The Li lab is well established and equipped in the structural biology, mass spectrometry, biochemistry, and cell biology studies of membrane proteins, and has developed novel methods for these studies, such as live cell footprinting (NSMB 2007) and fast structure determination (Sci. Adv. 2020). For cryo-EM, the lab gets regular time (about one week in every two months) in using Washington University’s own Titan Krios. Crystallization robots and regular APS time are available for crystallography studies. Close collaboration with Dr. Michael Gross lab affords us extensive access to mass spectrometry analyses.


Please send your CV, the names of three references, and a brief email detailing your research interest to weikai@wustl.edu.

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[Post Date: December 4, 2020]


Postdoc Positions and Lab Manager The Joyce Laboratory, Henry M. Jackson Foundation

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Description:

The Joyce Laboratory, Henry M. Jackson Foundation supporting the Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research have openings for two postdoctoral positions and a Lab Manager position in Structural Biology of Emerging Infectious Diseases. One postdoctoral position involves the structural and biochemical characterization of small molecule inhibitors against Emerging Infectious pathogens including SARS-CoV-2, as part of an integrated drug development pipeline at WRAIR. One postdoctoral position involves the structural and biochemical characterization of viral glycoproteins from Emerging Infectious pathogens including SARS-CoV-2 to enable vaccine development, antibody therapeutics and small molecule inhibitors. The Lab manager position will oversee day-to-day activities in the lab including lab inventory, ordering and routine mammalian cell culture and transient transfection. These positions offer a unique opportunity to gain extensive structural biology experience focused on vaccine and therapeutic development for pandemic prevention. Interested candidates should apply at the sites indicated below, or with a cover letter and a current CV directly to Gordon Joyce gjoyce@eidresearch.org

Postdoctoral Fellow: https://recruiting.ultipro.com/HEN1006HMJ/JobBoard/3a6861f3-0883-4466-8b7d-35e87635b33d/OpportunityDetail?opportunityId=badea1fa-6ab9-4be5-8ddb-57530404a901

Postdoctoral Fellow: https://recruiting.ultipro.com/HEN1006HMJ/JobBoard/3a6861f3-0883-4466-8b7d-35e87635b33d/OpportunityDetail?opportunityId=01d3c013-4b96-4f68-8d58-5ca1b631ba2e

Lab Manager: https://recruiting.ultipro.com/HEN1006HMJ/JobBoard/3a6861f3-0883-4466-8b7d-35e87635b33d/OpportunityDetail?opportunityId=a7a0f9d2-dd49-4009-96b6-df951fce9218


[Post Date: December 4, 2020]


Postdoc CNIO, Madrid, Spain

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Description:

We are looking for a highly motivated structural biologist to join the Crystallography and Protein Engineering Unit at the Spanish National Cancer Research Centre (CNIO), as a postdoctoral fellow, with a 20 months contract.

The work will be focused on developing a therapeutic molecules against SARS-CoV-2. The successful applicant will use interdisciplinary approaches including structural biology techniques (X-ray crystallography and cryoEM), molecular biology and biochemistry.

Feel free to contact me for informal inquiries.  Inés G. Muñoz, Head of Crystallography & Protein Engineering Unit, Structural Biology Programme imunoz@cnio.es


[Post Date: December 4, 2020]


Postdoc in Structural Biology UT Southwestern Medical Center at Dallas

View the Job Posting Here

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Description:

A postdoctoral position in structural biology is available in the Center for the Genetics of Host Defense at UT Southwestern Medical Center at Dallas. Using forward genetics, the lab identifies many proteins and protein complexes that have novel functions in the immune system, metabolism, and the nervous system. Many of these proteins and protein complexes are involved in diseases including immune deficiency, autoimmunity, inflammatory bowel disease, and diabetes. We are interested in using structural biology to develop molecular mechanisms that describe how these proteins and protein complexes function in the context of live cells and mice.  UTSW-Medical Center is well equipped with state of the art instrumentation for protein biochemistry, biophysics and structural biology. This includes monthly access the Advanced Photo Source synchrotron beamline, in-house robotic systems for screening and optimizing crystals, various high strength NMR magnets equipped for solution state and solid state NMR, and cryo-electron microscopes supported by the Cryo-Electron Microscopy Facility at UTSW-Medical Center. New Ph.D. graduates are highly encouraged to apply. Please visit the lab website at http://beutlerlab.org/ for more information.

Successful candidates are expected to be highly motivated and well trained in protein biochemistry, or in structural biology using NMR, X-ray crystallography or cryoEM. Please send the following to Betsy Layton at Betsy.Layton@utsouthwestern.edu, with the subject line NEW Postdoctoral Application in Structural Biology:

1)   A cover letter explaining your current research interests with a description of why you are interested in the Beutler laboratory.

2)   A complete CV with links to all of your publications.

3)   A list of three references, with their current work address, title, email address, and phone number.


[Post Date: December 3, 2020]


Structural Biologist – Computational Biologist - Brigham and Women’s Hospital

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Description:

The Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine at Brigham and Women’s Hospital seeks a PhD level recognized structural biologist with computational biology expertise who has published peer-reviewed first author scientific papers and authorships of protein data bank/NMR entries in CEACAM1, T cell inhibitory and mucin domain-3 containing proteins, and FcRn receptors, with a minimum of 5 years of post-doctoral experience.

Applicant should have a strong commitment to developing solutions to major unmet needs and must have significant experience in structural and biophysical approaches including x-ray crystallization, NMR spectroscopy, and small-angle X-ray scattering (SAXS). Proficiency in cloning, protein expression, protein purification, and characterization of protein-nucleic acid complexes using a variety of biophysical methods (for example: BIAcore, ITC, AUC, DLS and MST). Direct experience and access to national synchrotron sources such as Advanced Photon Source (APS) Argonne, IL, USA, National Synchrotron Light Source- II (NSLS-II), Upton, NY, USA) is necessary. Research experience in cryo-electron microscopy (cryo-EM) and single-molecule biophysics is desirable, however not required. This is a full-time position and involves teaching and training incoming prospective students or post-docs with all the aspects of structural biology techniques. Academic rank at Harvard Medical School (HMS) will be Instructor, and salary is commensurate with qualifications and experience.  Interested applicants should send their CV to: Richard Blumberg, MD (rblumberg@bwh.harvard.edu), Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115-6195.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, protected veteran status, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

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[Post Date: December 3, 2020]


Post-Doctoral Fellow Position Open at IMB Academia Sinica (Taipei Taiwan)

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Description:

Post-doctoral position is available in Dr. Hanna S. Yuan’s laboratory located in the Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan. We are looking for strong skills in structural biology and an interest in understanding the molecular mechanism of RNA-decay and DNA-modification enzymes (lab webpage: http://hyuan.imb.sinica.edu.tw/)). Benefits and salary commensurate with experiences are according to the Academia Sinica guidelines.

The applicants with experiences in protein biochemistry, structural biology and/or molecular biology, are preferred. Please send a cover letter with the contact information of three referees and CV to Dr. Yuan via E-mail (hanna@sinica.edu.tw).


[Post Date: December 2, 2020]


Postdoc in GPCR Biology at IIT Kanpur, India

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Description:

We have multiple post-doctoral positions available in our laboratory to work on cutting edge research projects related to GPCR biology (structural studies using X-ray crystallography and cryo-EM; discovering novel signaling pathways, and generating synthetic tools to modulate receptor signaling).

We are looking for candidates with relevant prior experience (protein biochemistry, cellular signaling, X-ray crystallography and cryo-EM).

Please refer to Science Advances, 2020 Sep 11;6(37):eabb8368; EMBO Reports, 2020 Sep 3;21(9):e49886; Structure, 2020 Sep 1;28(9):1014-1023.e4; Nature, 2020 Jul;583(7818):862-866; Science, 2020 Apr 24;368(6489):369-370; Cell, 2020 Mar 19;180(6):1041-1043, Cell Reports, 2019; Nature Structural & Molecular Biology, 2018 Jun;25(6):538-545; Nature Nanotechnology. 2017 Dec;12(12):1190-1198; Nature Communications, 2016 Nov 9;7:13416; for a general overview of our research directions and experimental approaches.

Interested applicants are requested to send their CV and names of three referees to arshukla@iitk.ac.in


[Post Date: November 30, 2020]


Postdoc Paul Scherrer Institute

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Description:

A postdoctoral position is immediately available at the Paul Scherrer Institute in the group of Dr. Richard A. Kammerer. The successful candidate will have a strong background in recombinant protein production and the biochemical and biophysical characterization of proteins. Expertise in X-ray crystallography and/or experience with membrane proteins is desirable. We look for a motivated individual who enjoys team work in a lab environment.

Our lab is interested in understanding the mechanisms underlying botulinum neurotoxin action, in particular the interaction between the toxin and its host cell receptor, toxin translocation and substrate specificity. To study these processes, we use X-ray crystallography, biochemical and biophysical methods and in vivo functional studies. For a publication representing our work, please see Benoit et al., Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A. Nature, 2014, 505, 108-111. More information can be obtained from Dr. R. A. Kammerer.

Candidates with a proven track record in international journals are encouraged to apply to Dr. Richard A. Kammerer, OFLC/106, Forschungsstrasse 111, Paul Scherrer Institute, 5232 Villigen, Switzerland, e-mail: richard.kammerer@psi.ch


[Post Date: November 30, 2020]


Scientist/Senior Scientist – Protein Expression from mammalian cells, Structural Biology

View the Job Posting Here

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Description:

Evotec (UK) Ltd is currently seeking to add to our Structural Biology Department.  The group works closely with our Discovery Chemistry Department and with clients to develop novel small molecule drugs.  The group is at the forefront of new science and technology, and is seeking to expand as business needs grow.

Required Knowledge, Skills and Abilities:

  • A working knowledge and practical experience with mammalian expression systems for recombinant protein expression is necessary
  • Experience with growing and transfecting suspension HEK293, Expi293 and CHO cells, from 3 ml to 10L scale, is necessary
  • Extensive knowledge of protein expression, especially of challenging targets, demonstrated through the delivery of innovative solutions for drug discovery programs
  • The successful candidate will have experience working in multi-disciplinary teams
  • Experience collaborating with scientists in external organisations would be an advantage

Responsibilities may include:

  • Supporting a project team by conducting experiments with defined, agreed objectives and timelines
  • Contributing to the design, execution and interpretation of experiments in a project team to accomplish project goals
  • Adapting scientific knowledge to resolve problems encountered in achieving defined goals with assistance from line manager or other team members to meet internal and project deadlines
  • Preparing reports of findings, presenting data, and collaborating with other scientists at Evotec and external clients
  • Presenting own work at project technical meetings, and department technical meetings when required
  • Demonstrating full command of all techniques and tools required for assigned responsibilities within the given project
  • Ensuring safe working practices of themselves and any direct reports
  • Complying fully with the company safety policy (including COPs and SOPs) when performing experiments
  • Reading scientific literature relevant to the project
  • Adhering to Lab Notebook guidelines regarding accurate documentation of lab experiments
  • Managing own projects and help the team members to manage their projects
  • Line management experience will be advantageous

Desirable Knowledge, Skills and Abilities:

  • Self-motivated, enthusiastic, cooperative and reliable
  • Knowledge of basic laboratory techniques, and understanding of the science underlying the techniques and experiments
  • Experience of working in a lab environment
  • The ability to adapt to changing demands whilst operating under pressure to deadlines
  • The ability to work accurately and with attention to detail
  • Good interpersonal skills and the ability to work well with other scientific staff
  • The ability to work well independently, and as part of a team
  • Good organisational and time management skills
  • Good verbal communication skills
  • Ability to maintain excellent laboratory records
  • Computer proficiency

Education and Experience:

PhD, MSc, BSc degree or equivalent in Biochemistry or related area

Candidates must be eligible to work in the UK.


[Post Date: November 25, 2020]


Postdoc in Drug Discovery Vanderbilt University

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Description:

 An opening is available in the drug discovery laboratory of Dr. Stephen Fesik at Vanderbilt University for a post-doc in the field of protein x-ray crystallography.  Responsibilities will include protein expression and purification, and all aspects of x-ray crystallography including preparation of protein-inhibitor complexes, crystallization, home/synchrotron data collection, and structure determination. Additional experiences in molecular biology including construct design, cloning, site-directed mutagenesis, and experience with recombinant protein expression in eukaryotic cells are highly preferred.  The ideal candidate should be self-motivated and be able to communicate efficiently in a highly collaborative environment. Please send cv to jason.phan@Vanderbilt.Edu


[Post Date: November 24, 2020]