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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Postdoctoral Fellow on Multidisciplinary Structural Biology

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Description:

Laboratory of Dr. Yongna Xing 

McArdle Laboratory of Cancer Research 

Wisconsin Institutes for Medical Research (WIMR) II 6451
University of Wisconsin-Madison 

A postdoctoral position on multidisciplinary structural biology is available to investigate the mechanisms and functions of phosphatase signaling complexes and their disease mutations in cancer and intellectual disability. We combine cryo-EM, x-ray crystallography, cell biology, system biology, biochemistry, computational biology, machine learning, and bioinformatics to gain critical knowledge on complex phosphatase signaling network dictated by both allosteric structured cores and versatile signaling motifs. The research is performed in a highly multidisciplinary setting with basic scientists with expertise on Cryo-EM, biochemistry, cell biology, bioinformatics and chemical biology. We are well equipped for multidisciplinary research, such as powerful GPU computers, liquid handling crystallization robot, and live cell imaging system. In addition, our lab is conveniently located near multiple shared facilities. Our research is built on collaborations with more than 10 groups from US and Europe as well as dynamic collaborations on campus in both basic and clinical research. UW-Madison has highly collaborative research environment that easily establish novel collaborations.  We are seeking productive, and motivated individuals with excellent organizational, interpersonal, and communication skills. We expect our candidates have strong expertise in cryo-EM, x-ray crystallography, and protein biochemistry. We also expect our candidates feel comfortable to expand their expertise and apply in-house bioinformatic tools and machine learning algorithms developed in the lab and work both independently and by collaboration toward personalized medicine for phosphatase diseases.  

The starting salary for promising candidate will be $54,000 or above. 

Review of applications will begin immediately and continue until the position is filled. To apply: Please send a cover letter, CV and the names and contact information for three references to Dr. Yongna Xing via email: xing@oncology.wisc.edu.  

Under-represented minorities are encouraged to apply. 


[Post Date: May 27, 2022]


Research Technician

View the Job Posting Here

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Description:

he European Molecular Biology Laboratory (EMBL) is one of the highest-ranked scientific research organisations in the world. The Headquarters Laboratory is located in Heidelberg (Germany) and further Units are situated Grenoble (France), Hamburg (Germany), Hinxton (UK), Rome (Italy) and Barcelona (Spain).

EMBL Grenoble shares the European Photon and Neutron Science (EPN) Campus with the European Synchrotron Radiation Facility (ESRF), the Institut Laue Langevin (ILL) and the French national Institut de Biologie Structurale (IBS), whose complementary and integrated facilities provide a very rich environment for structural biologists.

EMBL is seeking to recruit a Research Technician in the Head of Unit’s Research Group at EMBL Grenoble, Prof. Kristina Djinovic Carugo. The Djinovic group is interested in the molecular mechanisms underlying the architecture and assembly of muscle sarcomeres, particular Z-discs and microbial metalloenzymes involved in complete ammonium oxidation and protection from chemical damage. We use integrative structural biology methods including X-ray crystallography, small-angle X-ray scattering, electron microscopy and complementary biophysical and biochemical approaches on proteins and reconstituted complexes.

Your role

You will provide specific technical support to research projects of Djinovic Group, and assist the lab in a variety of biochemical, biophysical and structural studies, including gene cloning, protein expression, purification, and characterization of purified protein by various biochemical and biophysical techniques. You are also expected to help with the management of the lab, together with Lab Manager of the research group.

Other main tasks include:

  • General laboratory work: maintaining chemical stocks, keeping track of and managing laboratory supplies and ordering.
  • To be responsible for equipment maintenance and repair, including communications with company representatives.
  • To contribute to the training of students and fellows on laboratory practice and the equipment and techniques used.
  • To actively participate in ongoing research projects in the Djinovic group
Apply now

Closing date: 30 June 2022

You have

  • A degree in a relevant field (biology or related disciplines).
  • Working experience in molecular biology, molecular biophysics and biochemistry.
  • Project management experience, excellent communication skills and the ability to supervise and collaborate with other research teams.
  • Good knowledge of desktop software applications.
  • In a multi-lingual environment, excellent command of English is mandatory.

You might also have

  • Previous experience in the use of biophysical instrumentation and sample preparation for structural studies or any structural biology technique will be an advantage.
  • Fluency in French and other European languages would be an advantage.

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family and the availability of an excellent child care facility on campus.

What else you need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1900 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.

Please note that appointments on fixed-term contracts can be renewed, depending on circumstances at the time of the review.

Initial contract is for 3 years with a possibility of renewal up to 9 years.

Please compile an application package containing:

•    Letter of interest
•    Your CV
•    Contact details for two references

Please apply online through: www.embl.org/jobs

Interviews are planned for after the 6th July 2022.

Prospective start date: as soon as possible.

Further information about this position can be obtained from the Head of EMBL Grenoble, Kristina Djinovic Carugo (kristina.djinovic@embl.org).


[Post Date: May 27, 2022]


Laboratory Manager

View the Job Posting Here

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Description:

The European Molecular Biology Laboratory (EMBL) is one of the highest-ranked scientific research organisations in the world. The Headquarters Laboratory is located in Heidelberg (Germany) and further Units are situated Grenoble (France), Hamburg (Germany), Hinxton (UK), Rome (Italy) and Barcelona (Spain).

EMBL Grenoble shares the European Photon and Neutron Science (EPN) Campus with the European Synchrotron Radiation Facility (ESRF), the Institut Laue Langevin (ILL) and the French national Institut de Biologie Structurale (IBS), whose complementary and integrated facilities provide a very rich environment for structural biologists.

EMBL is seeking to recruit a Lab Manager in the Head of Unit’s Research Group at EMBL Grenoble, Prof. Kristina Djinovic Carugo. The Djinovic group is interested in the molecular mechanisms underlying the architecture and assembly of muscle sarcomeres, particular Z-discs and microbial metalloenzymes involved in complete ammonium oxidation and protection from chemical damage. We use integrative structural biology methods including X-ray crystallography, small-angle X-ray scattering, electron microscopy and complementary biophysical and biochemical approaches on proteins and reconstituted complexes. The group shares expertise and research infrastructures with other EMBL research groups in Grenoble.

The Lab Manager will be involved in organization of the laboratory and will contribute to scientific projects in the lab.

Your role

Scientific Research

- Participate in ongoing scientific projects involving cloning, protein expression in bacteria, insect and mammalian cell lines, protein purification, biochemical and biophysical characterization of proteins and protein complexes.

- You will design, perform and troubleshoot experiments in an independent manner, and preferably lead own research project.

- Test of new experimental approaches and projects in their start-up phase.

Supervision and training 

- Train new group members and visitors in using the lab’s equipment, spaces, databases, software resources etc. as well as in technologies/techniques commonly used in the lab.

- Test new tools, reagents and equipment; establish and improve experimental protocols.

- Supervise trainees, visitors and students.

Lab Management

- General laboratory management, including administration of reagent databases, instrument maintenance and, space organization of the laboratory and the office.

- Serve as an interface between EMBL's service departments (building maintenance, scientific instrument maintenance, workshops, and core facilities) and the research Group.

- Interfacing with scientists and research technicians in other Units.

- Support Group and Unit staff at the level of Unit organisation.

Apply now

Closing date: 30 June 2022

You have

  • Experience as a research technician/lab manager/research scientist with relevant education and strong expertise in molecular biology, molecular biophysics and biochemistry.
  • Broad technical, organizational, interpersonal and management skills and exceptional reliability.
  • Good knowledge of software applications for inventory, writing reports and presentations are also mandatory.
  • In a multi-lingual environment, excellent command of English is mandatory.
 

You might also have

  • Previous experience in use of biophysical instrumentation and sample preparation for structural studies or any structural biology technique will be an advantage.
  • Fluency in French and other European languages would be an advantage.

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family and the availability of an excellent child care facility on campus.

What else you need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1900 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research. Please note that appointments on fixed-term contracts can be renewed, depending on circumstances at the time of the review. 

Initial contract is for 3 years with a possibility of renewal up to 9 years.

Please compile an application package containing:

•    Letter of interest
•    Your CV
•    Contact details for two references

Please apply online through: www.embl.org/jobs

Interviews are planned for after the 6th July 2022.

Prospective start date: as soon as possible.

Further information about this position can be obtained from the Head of EMBL Grenoble, Kristina Djinovic Carugo (kristina.djinovic@embl.org).


[Post Date: May 27, 2022]


Staff Scientist

View the Job Posting Here

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Description:

The European Molecular Biology Laboratory (EMBL) is one of the highest-ranked scientific research organisations in the world. The Headquarters Laboratory is located in Heidelberg (Germany) and further Units are situated Grenoble (France), Hamburg (Germany), Hinxton (UK), Rome (Italy) and Barcelona (Spain).

EMBL Grenoble shares the European Photon and Neutron Science (EPN) Campus with the European Synchrotron Radiation Facility (ESRF), the Institut Laue Langevin (ILL) and the French national Institut de Biologie Structurale (IBS), whose complementary and integrated facilities provide a very rich environment for structural biologists.

EMBL is seeking to recruit a Staff Scientist in the Head of Unit’s Research Group at EMBL Grenoble, Prof. Kristina Djinovic Carugo. The Djinovic group is interested in the molecular mechanisms underlying the architecture and assembly of muscle sarcomeres, particular Z-discs and in microbial metalloenzymes involved in complete ammonium oxidation and protection from chemical damage. We use integrative structural biology methods including X-ray crystallography, small-angle X-ray scattering, electron microscopy and complementary biophysical and biochemical approaches on proteins and reconstituted complexes.

Your role

You will lead and contribute to research projects of the Djinovic group, specifically in areas of (but not limited to) protein expression (including eukaryotic hosts), purification, biochemical and biophysical characterization, as well as structural biology approaches. You will also contribute to grant applications and manuscript preparation, support of active grants, presentations of group activities at external meetings and training of young researchers in relevant methods and technologies. S/he will be able to develop her/his own projects primarily in the field of structural biology of muscle cytoskeleton.

Apply now

Closing date: 30 June 2022

 

You have

You should have a PhD in a relevant field and at least three years of postdoctoral work that has resulted in significant peer reviewed publications. Working experience and theoretical knowledge in molecular biology, protein expression in eukaryotic hosts and purification, biochemistry, molecular biophysics and structural biology approaches. Project management experience, excellent communication skills and the ability to supervise and collaborate with other research teams are essential. Good knowledge of desktop software applications and fluency in English are mandatory.

 

You might also have

Previous experience in complementary structural biology methods, cell biophysics approaches (e.g. FRET, FRAP, BiFC) and cell culture will be considered an advantage.

 

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family and the availability of an excellent child care facility on campus.

 

What else you need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1900 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.

Please note that appointments on fixed-term contracts can be renewed, depending on circumstances at the time of the review.

Initial contract is for 3 years with a possibility of renewal up to 9 years.

Please compile an application package containing:

•    Letter of interest
•    Your CV
•    Contact details for three references

Please apply online through: www.embl.org/jobs

Interviews are planned for after the 10th July 2022.

Prospective start date: as soon as possible.

Informal inquiries should be sent to Kristina Djinovic Carugo (kristina.djinovic@embl.org).


[Post Date: May 27, 2022]


Senior/Principal Scientist, Structural Biology

View the Job Posting Here

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Description:

Ambagon Therapeutics is an early-stage biotechnology company dedicated to the discovery and development of molecular glues stabilizing the interaction between the 14-3-3 adaptor proteins and their disease-promoting client proteins. Our academic founders are the world leaders in this novel approach and launched Ambagon with a mission to engage undruggable target classes to provide new therapies for unmet medicalneeds in cancer and other diseases. Ambagon is a rapidly growing company with two sites (San Francisco CA, USA and Eindhoven, Netherlands) that closely collaborate. Learn more about our company at our website: www.ambagontx.com.

We are seeking a highly motivated structural biologist for the Eindhoven team. This position will be a critical member of the multidisciplinary team reporting to the US based Executive Director, Structural Biology and Informatics. This is an exceptional opportunity to contribute and impact drug discovery and development in a fast-paced biotech company. As Principal/Senior Scientist in the Structural Biology group, you will be responsible for the crystallography of binary and ternary complexes of 14-3-3 proteins. Furthermore, you will be involved in the integration of the collected structural data in a company database. As the leading scientist on site, you will be the day to day go to person for the dutchbased team.

You will be working in a close team that is very science driven and really wants to make an impact for patients. values communication, inclusion and respect. We are a very flat organization, where everyone’s input is appreciated and we believe that we grow together. We are a scale-up, so flexibility and adaptability are key to success.

Responsibilities include, but are not limited to:

  • Carry out high throughput crystallization experiments and manage synchrotron data collection
  • Determine and interpret crystal structures of binary and ternary complexes of 14-3-3 proteins, with emphasis on high quality ligand fitting and guidance to chemistry design
  • Allocate appropriate resources to ensure timely achievement of corporate goals and project milestones
  • Prepare and deliver scientific presentations and reports to communicate structural findings to colleagues within and outside the structural biology team
  • Collaborate closely and effectively with multifunctional teams, including Medicinal Chemistry, Biochemistry and Cancer Biology to develop and implement strategies to advance discovery programs
  • Maintain a command of relevant scientific literature, research/mine public domain structure data, and evaluate implications for internal projects
  • Assume responsibility for maintaining laboratory equipment, facilitate their use by other scientists, and maintain clear, detailed, and up-to-date experimental records
  • Conduct other duties as assigned

Job Requirements:

  • PhD in Biology, Chemistry, Chemical Biology, Biochemistry or Structural biology
  • You have at least 4 years of industry experience
  • Extensive experience with macromolecule crystallization, synchrotron X-ray diffraction data collection, data processing, and structure determination and refinement
  • Understanding of the principles of various phasing methods, density modification and model building techniques, refinement and structure validation methods
  • Proficiency in Linux, CCP4, Phenix, Coot, PyMOL and at least one scripting language (i.e. python, perl and etc)
  • Cryo-EM experience is a significant plus but not mandatory
  • Expert knowledge on protein purification, protein sample characterization and protein construct design for crystallography
  • In-depth knowledge of the principles of protein structure, conformational dynamics, protein-ligand interactions and implications for drug design
  • Highly motivated and able to work in a fast-paced environment
  • Demonstrated technical proficiency, scientific creativity, sense for detail and accuracyhigh standard of integrity and problem-solving ability
  • Excellent interpersonal, verbal and written communication skills are essential in this collaborative work environment
  • Desire to learn and tackle new challenges is imperative
  • You need to have a work permit for the Netherlands

What we offer

  • Function title: Senior or Principal Scientist, depending on your seniority
  • Fulltime (40 hour) work week, but we can discuss 32 hours as a minimum
  • Motivated and close team
  • Competitive remuneration package, with base, bonus and equity


[Post Date: May 23, 2022]


Scientist, Structural Biology

View the Job Posting Here

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Description:

Ambagon Therapeutics is an early-stage biotechnology company dedicated to the discovery and development of molecular glues stabilizing the interaction between the 14-3-3 adaptor proteins and their disease-promoting client proteins. Our academic founders are the world leaders in this novel approach and launched Ambagon with a mission to engage undruggable target classes to provide new therapies for unmet medical needs in cancer and other diseases.  Ambagon is a rapidly growing company with two sites (San Francisco CA and Eindhoven, Netherlands) that closely collaborate. We are a close-knit team that values communication, inclusion and respect.

Learn more about our company at our website: www.ambagontx.com.

For our team in Eindhoven, we are looking for a new colleague! As (Senior) Scientist Structural Biology you will be responsible for the crystallography of binary and ternary complexes of 14-3-3 proteins with their partner proteins and molecular glues. Furthermore, you will be involved in the integration of the collected structural data in a company database and other duties as assigned.  You will be working in a close team that values communication, inclusion and respect.

Job Requirements (include, but are not limited to):

  • PhD in chemistry, Chemical Biology, Biochemistry, Molecular and Cellular Life Sciences or equivalent
  • 4+ years of experience and training in X-ray protein crystallography is an absolute requirement.
  • Proficiency in Linux, CCP4, Phenix, Coot, PyMOL
  • Experience in structure-based molecule design
  • Comfortable in a fast paced small company environment
  • Good team skills; comfortable in an interdisciplinary and international environment
  • Experience in scripting and programming would be considered an advantage
  • Sense for detail and accuracy
  • High standard of integrity
  • Ability to multi-task and manage workload independently
  • Enthusiastic about science!

What we offer

  • Function title: (Senior) Scientist
  • 1-year contract with possibilities for a permanent contract
  • 32 to 40 hour work week
  • Motivated and close team
  • Competitive salary


[Post Date: May 23, 2022]


Research Associate, Protein X-Ray Crystallography

View the Job Posting Here

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Description:

Ambagon Therapeutics is an early-stage biotechnology company dedicated to the discovery and development of molecular glues stabilizing the interaction between the 14-3-3 adaptor proteins and their disease-promoting client proteins. Our academic founders are the world leaders in this novel approach and launched Ambagon with a mission to engage undruggable target classes to provide new therapies for unmet medical needs in cancer and other diseases.  Ambagon is a rapidly growing company with two sites (San Francisco CA and Eindhoven, Netherlands) that closely collaborate. We are a close-knit team that values communication, inclusion and respect.

Learn more about our company at our website: www.ambagontx.com.

For our team in Eindhoven we are looking for a new colleague! As ‘Research Associate Protein X-Ray Crystallography’ be responsible for the crystallography of binary and ternary complexes of 14-3-3 proteins with their partner proteins and molecular glues (and other duties as assigned).You will be working in a close-knit team that values communication, inclusion and respect.

Job requirements:

  • Bachelor or Master’s degree in Chemical Biology, (Bio)Chemistry, Biology, Medical Science, Life Sciences or related field.
  • Experience with protein crystal generation, data collection and structure elucidation by X-ray protein crystallography is an absolute requirement.
  • Excellent record keeping and organizational skills.
  • Experience with biophysical techniques and biochemical protein assays is a plus.
  • Comfortable in a small company environment that is fast paced, challenging and where all staff must take on a hands-on approach to get results.
  • Good team skills: comfortable in an interdisciplinary and international environment and able to effectively communicate and to collaborate in a team.
  • While being a true team player, you are also capable of working independently.
  • Strong written and oral communication skills.
  • Ability to multi-task and manage time efficiently.
  • Enthusiastic about science!

What we offer:

  • Function title: Research Associate (RA).
  • 1-year contract with possibilities for a permanent contract.
  • 32 to 40 hour working week.
  • A motivated and close team.
  • Competitive pay.


[Post Date: May 23, 2022]


Postdoctoral Fellow - Structural Biology and Cancer Therapeutics

View the Job Posting Here

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Description:

We currently have a Postdoctoral Fellowship position within a research team headed by Dr. Jeff Perry, Assistant Professor, Department of Molecular Diagnostics and Experimental Therapeutics, and member of the City of Hope Comprehensive Cancer. We are looking for a post-doctoral candidate with experience in protein crystallography and/or biophysical methods that include isothermal calorimetry and surface plasmon resonance.

The Perry laboratory uses structural biology approaches, together with fragment-based drug discovery, computer-aided drug discovery approaches and biochemical assays to target key proteins driving carcinogenesis. This DoD funded position is for a postdoctoral trainee interested in aiding the development of cancer therapeutics against a novel therapeutic target.

Key Responsibilities include:

  • Devise, plan, document and advance basic science-based projects in the area of structural biology and drug discovery.
  • Generate data for grant applications and prepare manuscripts for publication.
  • Work in close collaboration with other team members and external collaborators, including presentation of progress internally or externally.
  • Train and supervise technical staff.
Basic education, experience and skills required for consideration:
  • A Ph.D. in Biochemistry, Biophysics or a related discipline is required.
  • Evidence of scientific rigor and excellence as documented by peer-reviewed publications.
  • Ability to work in a fast-paced research environment and manage multiple projects and collaborations.
  • Strong team player with excellent communication skills and fluency in English, both spoken and written.

Details on the Perry lab at COH can be found at: cityofhope.org/jeff-perry-lab 


[Post Date: May 20, 2022]


Crystallizatoin Specialist

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Description:

Biotech Desk, located at Hyderabad, India is looking to recruit a crystallization specialist for maintenance and installations of the Oryx robots for protein crystallization. The person would also be in charge of their lab services involving protein crystallization using client proteins as a fee for service. Different constructs of the protein will be expressed, purified and crystallized including both screening of crystal forming conditions and optimization. Candidates who have completed their post-graduation in Life sciences, Biophysics or related fields may apply. The job is a right mix of bench work and customer interaction. Previous sales experience is helpful but not essential. Interested candidates may send their resumes to Ms. Kavitha at admin@biotechdesk.com. Remuneration depends upon the qualification of the person applying.


[Post Date: May 18, 2022]


Postdoc ALBA Synchrotron

View the Job Posting Here

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Description:

We are looking for an enthusiastic and motivated early-career postdoc to study the structural aspects of auxin-dependent transcription regulation in plants, and/or plasmid conjugation in gram-positive bacteria at the ALBA synchrotron (Barcelona, Spain).

The project is a continuation of the research lines of a highly successful research group, including publications in Cell (10.1016/j.cell.2013.12.027), Nature Communications (10.1038/s41467-020-16032-y), Nucleic Acids Research (10.1093/nar/gkaa540 and 10.1093/nar/gky996), Nature Plants (10.1038/s41477-020-0662-y) and PNAS (10.1073/pnas.2009554117).

At the ALBA synchrotron, exciting times lie ahead for structural biologists. Recently, a new EM facility has been built and is being commissioned at the moment. In addition, an upgrade of the storage ring will come to fruition in the coming 5-10 years. Furthermore, a microfocus beamline is under construction that will be open to friendly users in the year to come. These instruments will complement the macromolecular crystallography, SAXS, infrared microscopy and X-ray microscopy beamlines currently in operation. The facility is located near Barcelona, which is a great city to live and work.


[Post Date: May 17, 2022]


Postdoc Position at Fox Chase Cancer Center, Philadelphia, USA

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Description:

A postdoctoral position is available at Fox Chase Cancer Center, Temple University Health System (Philadelphia, PA) for a highly-motivated individual in the field of structural biology and protein biochemistry. 

Fox Chase Cancer Center is a long-standing NCI-designated Comprehensive Cancer Center with multidisciplinary research interests from basic biological sciences to drug development and clinical studies. The institute is located in a quiet, safe, and convenient neighborhood at the outskirts of the city. It is one of the top-ranked work places for visiting scholars and postdoctoral researchers in the US.

The research in the lab focuses on structural and mechanistic studies of the signaling events mediated by integrins, small GTPases, as well as kinases, which have strong implications in cancer progression, metastasis and other human diseases, and employing these new insights into inhibitor/drug discovery.  (https://www.foxchase.org/people/jinhua-wu.). The lab is equipped with top-notch crystallographic instruments including a Mosquito robot, a Formulatrix crystal imager, and a brand-new Synergy-S X- ray home source. We also have frequent remote beamtimes at BNL and MacChess synchrotrons.  The candidate should hold a Ph.D. degree with strong experience in X-ray crystallography, protein biochemistry, and molecular biology. Prior experiences in mammalian cell culture, flow cytometry, drug screen, and cancer biology, are desired but not required. We also offer an outstanding research environment and strong support for the career development for our scientists.

If you are interested, please send a cover letter describing previous research experience and future plans, a current CV, and a list of three references to: Jinhua.wu@fccc.edu.


[Post Date: May 17, 2022]


Postdoc Charles Sturt University

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Description:

We have a 3 year postdoctoral position in our lab investigating viral:host protein interactions. Our lab uses X-ray crystallography and cryoEM approaches, and we have regular access to the Australian Synchrotron. We are based in Wagga Wagga, NSW, Australia. For further information, please see our website, and/or feel free to contact me on jforwood@csu.edu.au.

http://csusap.csu.edu.au/~jforwood/


[Post Date: May 10, 2022]


Full Professorship in Biochemistry Universität Greifswald

View the Job Posting Here

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Description:

The University of Greifswald is currently seeking to appoint a full professor (m/f) of biochemistry (Biochemie III). You can find the official advertisement at the Universität Greifswald homepage:

https://www.uni-greifswald.de/universitaet/information/stellenausschreibungen/professuren/stellenausschreibung/n/w2-professur-fuer-biochemie-iii/

Euraxess: https://euraxess.ec.europa.eu/jobs/779824

To repeat some points, the topics  protein biochemistry and modern biochemical-analytical methods are explicitely mentioned. Greifswald university has a research focus on proteomics and protein technologies open for extension and collaborations. A group using protein crystallography does exist in the institute (Prof. Lammers), so a pure focus on protein crystallography will have a hard time to convince the committee, but related fields are welcome. Using the new in house X-ray generator and crystallization facilities will be possible, though. Neighbouring groups also have equipment and expertise in various bioanalytical methods as ITC, SPR, fluorimetry, DLS. A 600 MHz NMR also exists in the institute which is currently run by the  Biochemie III group. As written in the advertisement, applications of female scientists are particularly welcome.

The deadline for the application is June 24, 2022.


[Post Date: May 10, 2022]


Head of Instrumentation Team

View the Job Posting Here

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Description:

The European Molecular Biology Laboratory (EMBL) in Grenoble has an active research and international visitors program in structural molecular biology, making particular use of synchrotron X-rays and cryo-electron microscopy as structure determination techniques.

EMBL Grenoble shares the European Photon and Neutron Science (EPN) Campus with the European Synchrotron Radiation Facility (ESRF), the Institut Laue Langevin (ILL) and the French national Institut de Biologie Structurale (IBS), whose complementary and integrated facilities provide a very rich environment for structural biologists.

The EMBL Grenoble Instrumentation Team (https://www.embl.org/groups/grenoble- instrumentation/) designs and builds state-of-the-art, automated sample handling instrumentation for high-throughput crystallisation (e.g. the CrystalDirect automated harvesting robot), macromolecular crystallography (e.g. the MD2 and MD3 micro/nano diffractometers and Flex- HCD frozen crystal sample changer), small-angle scattering (e.g. sample changer and multi- modal sample exposure unit), X-ray imaging (versatile sample holders) and cryo-electron microscopy (automated cryo-grid preparation for cells and single-particles). The team is also responsible for operational deployment and subsequent support, IP protection and technology transfer to industry. The team collaborates closely with end-user scientists including the in house High-throughput Crystallisation and Synchrotron Diffraction Teams, the European Synchrotron Radiation Facility for technology implementation on jointly run X-ray beamlines, the Imaging Center at EMBL Heidelberg and with EMBL Hamburg, which runs X-ray beamlines for structural biology on the Petra III synchrotron at DESY, as well as other synchrotron sites.

Your role

EMBL Grenoble is seeking to recruit a visionary team leader with demonstrable engineering expertise in the design, construction and deployment of state-of-the-art, highly automated scientific instrumentation. The selected candidate will lead a team (currently 8 members) of scientists, engineers and technicians that develop, upgrade and maintain gold-standard, sample- handling instrumentation for structural biology (macromolecular crystallography, electron microscopy/tomography) and bioimaging (X-ray imaging, CLEM). Projects typically involve the integration of complex workflows, often at cryogenic temperatures, using high precision mechatronic techniques and resulting in robust, automated equipment with a user-friendly interface. The team leader will develop innovative solutions in collaboration with scientists and manage instrument design, construction, testing, deployment and maintenance. Publication of results and potential technology transfer to the industry are also expected. As a member of EMBL’s faculty, the candidate will take part in strategic discussions about future directions, and proactively engage in acquiring financial support for projects through national French or EU grants.

You have

Applicants should have an advanced degree in engineering, computer science, image analysis or robotics and several years of experience in the development of innovative, high precision automated scientific instrumentation in either industry or academia. The candidate should also have demonstrable experience in project management involving recruiting and coordinating a multidisciplinary team of mechatronic engineers to produce innovative scientific instrumentation to state-of-the-art industrial standards within challenging timelines.

Proactive and self-motivated, the ideal candidate is able to communicate and defend his/her work in English, but also appreciates working in a team and is capable of sharing decisions. S/he should have good communication skills in English, and should be enthusiastic about working in a highly international environment. A good working knowledge of French is an advantage.

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment.

The remuneration package comprises from a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family.

Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.

What else you need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science.

We are an international, innovative and interdisciplinary laboratory with more than 1800 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.

Interviews will take place in between 30th June and 8th July 2022. Please submit your CV, cover letter, and names of three referees. Please apply online through: www.embl.org/jobs

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[Post Date: May 2, 2022]


Postdoc NISER, Bhubaneswar, India

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Description:

One postdoctoral position is available at the School of Biological Sciences, NISER, Bhubaneswar, India. Dr. Ram Srini is looking for a motivated individual with prior experience in Cryo-EM and biochemistry is highly desirable. Currently, a 200 keV Cryo-electron microscopy is getting installed in the institute. Currently, Srini's group is working on biochemical, cell biological, and structural aspects of Bacterial Pathogenesis, Cytoskeletal Dynamics, and Synthetic Biology.

For details of this position, feel free to write to Dr. Ramanujam Srinivasan at rsrini@niser.ac.in with your CV. Please help to pass the information to your colleagues.


[Post Date: April 30, 2022]


Postdoc Institute of Life Sciences, Bhubaneswar, India

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Description:

We are looking for a motivated postdoctoral candidate with experience in protein crystallography and biophysical characterization methods. Interested candidates may write to Dr. Dileep Vasudevan at dileep@ils.res.in with your CV. Dr. Dileep is an amazing mentor and his lab has several exciting projects on chromatin, histone chaperone, HDAC, some viral proteins, and Clp protein machinery,

Our facilities include Fluorescence spectroscopy, MicroCal PEAQ-ITC and CD-spectroscopy, and Analytical Ultracentrifuge (Beckman Coulter – Optima AUC). Our lab also housed an in-house X-ray diffractometer (Rigaku MicroMax 007HF with a HyPix6000 photon-counting detector), along with a crystallization robot (FORMULATRIX NT8, and SPTLabTech Mosquito XTal3). Our group has access to the ESRF beamline as well.

For more details, please visit https://dvasulab.com 


[Post Date: April 30, 2022]


Advisor - Structural Biologist

View the Job Posting Here

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Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

We are seeking an exceptional structural biologist to join a dynamic and highly collaborative team of scientists within the Molecular Pharmacology department. Our talents spans enzymology, biophysics, cell pharmacology, chemical biology, analytical technologies, and structural biology to uncover mechanistic insights vital to understand the molecular basis of therapeutics and to drive drug discovery efforts. The position is focused on the determination of macromolecular structures by crystallography and cryo-EM. We apply the results to design and improve novel therapeutics in a collaborative environment supporting Lilly’s drug discovery.

Do you possess excellent interpersonal skills and enjoy working in a collaborative team environment? This is an excellent opportunity to join a diverse and dynamic team! Consider applying and joining the Lilly family today!

Basic Requirements:

  • PhD in structural biology, biophysics, biochemistry, chemistry, or other relevant field; post-doctoral experience is preferred.
  • Masters with 6+ years or Bachelors with 10+ years of relevant experience preferably in an industrial, drug discovery setting are also encouraged to apply.

Additional Preferred Skills :

  • Experience in protein crystallography including crystallization, diffraction data processing, structure determination and analysis. Extensive experience with construct design, protein expression and purification.
  • Experience determining structures by cryo-EM will be a plus.
  • Ability to lead several structural biology projects in parallel, flexibility to work in an environment with rapidly changing priorities and deadlines, strong interpersonal, written & oral communication, problem-solving skills and capability to prioritize.
  • Partner closely with biologists, biophysicists, biochemists, structural biologists and medicinal chemists to develop integrative approaches to enable targets and address specific project needs
  • Experience in structure based drug design will be a plus.
  • Experience in a scripting language is advantageous. Familiarity with other biophysical methods (E.g., MS, bioNMR, SPR, ITC, etc.) would be helpful.
  • Present and publish scientific findings in the broader scientific community.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law). 


[Post Date: April 30, 2022]


Advisor-Protein Crystallography

View the Job Posting Here

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Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Discovery Chemistry & Technologies organization within Lilly Research Laboratories is a diverse and dynamic group seeking a highly skilled scientist to join the structural biology team. We support drug discovery for numerous innovative projects and are looking for someone to inspire change in the drug hunting process. The primary focus will be to lead in the development and deployment of methodologies to accelerate structure-based drug design. Broad experience with proteins, along with a proven track record of structural determination is required. We are a diverse team of scientists and strive for excellence and innovative solutions to find therapies for our patients. Join our team today and make an impact!

Required Experience and Skills

  • Expert in protein crystallography including crystallization, structure determination and analysis; experience with construct design, protein expression and purification
  • Experience determining structures by cryo-EM will be a plus
  • Ability to lead several structural biology projects in parallel
  • Partner closely with biologists, biophysicists, biochemists, structural biologists, and medicinal chemists to develop integrative approaches to enable targets and address specific project needs
  • Work closely with groups within structural biology, and as a member of broader teams that may include synthetic chemists, computational chemists, biologists, enzymologists, and ADME scientists
  • Ability to generate macromolecular structures and communicate the relevant results to a diverse drug discovery team, and the capacity to contribute to small-molecule design efforts

Are you a highly motivated individual with the ability to thrive in a fast-paced, team-oriented drug-discovery setting? Apply today! The patient is waiting!

Basic Qualifications

PhD in biological sciences, biochemistry, chemistry, or related field with at least 2 years of relevant experience; or Master's/Bachelor’s degree in biological sciences, biochemistry, chemistry, or related field with at least 8 years of relevant experience

Additional Skills/Preferences

  • Experience in drug discovery, or with computational approaches to small molecule drug design, would be advantageous
  • Familiarity with biophysical or biochemical techniques that are complementary to X-ray crystallography
  • The position is based in San Diego, California, but the ability to conduct occasional travel to Indianapolis, Indiana (or other relevant sites) will be useful for coordinating with project teams and other colleagues

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law). 


[Post Date: April 30, 2022]


Postdoc University of Munich

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Description:

A postdoctoral position is open in Ivan Huc's group at the LMU. Please see pdf link.

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[Post Date: April 27, 2022]


Scientist, X-ray Crystallography Janssen Research & Development, L.L.C.

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Description:

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Scientist, X-ray Crystallography, located in La Jolla, CA!

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The Discovery Technologies and Molecular Pharmacology group is a dynamic, diverse and critical part of the Discovery Sciences organization in Janssen R&D. We are committed to the discovery and characterization of high-quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Areas. This mission requires deep scientific expertise across broad subject areas including chemistry, cellular and molecular pharmacology, enzymology, screening, protein science, and structural biology coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding and motivated individual to join our team as Scientist, X-ray Crystallography.

As the Scientist you will:

  • Be an active member of drug discovery teams, working closely with computational and medicinal chemists on structure-based drug design approaches for small molecule agent optimization.
  • Be responsible for crystallization of protein-small molecule complexes, determination of high-resolution structures by X-ray crystallography and communicating these results to the project team.
  • Work closely with protein scientists, biophysicists, protein NMR and cryo-EM scientists as part of an integrated structural biology effort.
  • Contribute to multidisciplinary Fragment-Based Lead Discovery (FBLD) efforts.
  • Contribute to enhance the structural biology scientific expertise of the group by publishing high-impact research papers, and presenting at scientific conferences, internalizing impactful technologies and platforms, and establishing academic collaborations.
  • Mentor lab scientists and contribute to the strategic planning of the Structural Biology group.

Qualifications

  • BS degree with at least 12 years of experience, OR MS degree with at least 9 years of experience, OR a Ph.D. or equivalent and postdoctoral experience in structural biology (X-ray crystallography, biophysics, protein engineering) or related field is required
  • Expertise with crystallography software packages (Phenix/CCP4/PyMol/Moe) in a mixed Linux/Windows computational environment is required
  • Scientific expertise in structural biology, with strong experience in both protein crystallization and structure determination is required
  • Strong record of external publications and presentations is required
  • Outstanding written and oral communication skills are required
  • Experience in Structure-Guided Drug Design utilizing X-ray crystallography is preferred
  • Research experience in cryo-electron microscopy (Cryo-EM), Micro-electron diffraction (Micro-ED), protein NMR or orthogonal structural biology technologies is preferred
  • Research experience with other biophysical techniques such as MST, ITC, NMR, DSF, SPR is preferred
  • Broad knowledge of biophysics, biochemistry, molecular pharmacology, and protein sciences is preferred.
  • Experience in scientific programming (Unix shells, Python) is preferred
  • Expertise in one or more of the following therapeutic areas: Oncology, Inflammation, Neuroscience, Cardiovascular, and Infectious Diseases is preferred

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Primary Location
United States-California-San Diego-
Organization
Janssen Research & Development, LLC (6084)
Job Function
R&D
Requisition ID
2005866689W


[Post Date: April 27, 2022]


Scientist, Biochemistry CHARM Therapeutics, Cambridge, United Kingdom

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Description:

CHARM Therapeutics is a biotech company focused on delivering transformational medicines that will address difficult-to-drug targets in key oncogenic pathways. CHARM has developed the first highly accurate, high throughput protein-ligand co-folding algorithm (DragonFold), driven by end-to-end 3D deep learning. Our platform enables the rapid generation of highly differentiated clinical candidates, and our ambition is to revolutionise drug discovery. CHARM Therapeutics is establishing a state-of-the-art R&D facility in Cambridge, UK. 

We are currently seeking a motivated Biochemist to join the Structural Sciences group at CHARM Therapeutics. The position is within a lab-based team, working on high throughput crystallographic and CryoEM structural targets to fully enable and drive multiple SBDD / Med Chem campaigns.  The successful candidate will join a multidisciplinary, highly collaborative discovery team to invent novel medicines and drive them towards the clinic.

Role Requirements:

The successful candidate will be expected to meet the following criteria:

A degree in biochemistry / molecular biology, or a related discipline, is required.

Experience in a biotech/pharma setting may be advantageous.

Molecular biology / cloning / protein engineering skills and knowledgeable in expression construct design, and downstream purification strategies.

Demonstrable experience in the expression and purification of target proteins from recombinant systems (both bacterial and eukaryotic advantageous) utilising various affinity systems.

Experience in the use of FPLC systems and different approaches to purify recombinant target proteins to homogeneity.

Knowledgeable in the application of protein biochemistry to aspects of drug discovery programs including structural biology and biophysical analyses

Excellent organisational / interpersonal skills with the ability to work as part of a team.

What is on Offer:

The chance to work in a highly collaborative, progressive and intellectually stimulating environment, applying state of the art AI-based techniques to revolutionise drug discovery.

Competitive base salaries along with regular appraisals and reviews.

Share options in CHARM Therapeutics through the EMI scheme.

Private Healthcare, including dental and optical.

Gym membership.

Budget for employee development; training courses and conferences.

Fruit and snacks delivered to our offices.


[Post Date: April 22, 2022]


Senior Scientist Crystallography, CHARM Therapeutics, Cambridge, United Kingdom

View the Job Posting Here

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Description:

CHARM Therapeutics is a biotech company focused on delivering transformational medicines that will address difficult-to-drug targets in key oncogenic pathways. CHARM has developed the first highly accurate, high throughput protein-ligand co-folding algorithm (DragonFold), driven by end-to-end 3D deep learning. Our platform enables the rapid generation of highly differentiated clinical candidates, and our ambition is to revolutionise drug discovery.  CHARM Therapeutics is establishing a state-of-the-art R&D facility in Cambridge, UK.  We are seeking an exceptional protein crystallographer with a passion for scientific innovation.  The successful candidate will join a multidisciplinary, highly collaborative discovery team to invent novel medicines and drive them towards the clinic. 

Role

We are currently seeking an experienced protein crystallographer to join the structural sciences group at CHARM Therapeutics working on high throughput crystallographic structure determination to fully enable and drive multiple SBDD campaigns.

Requirements

The successful candidate will be expected to meet the following criteria:

  • A PhD level qualification in protein crystallography, or a related discipline, is required.
  • Additional previous experience in an industrial / biotech setting would be preferred. 
  • Familiarity with cloning, expressing and purifying multiple target proteins from recombinant systems (both bacterial and eukaryotic) specifically in oncology, alongside higher molecular weight complexes and integral membrane proteins for structural and biophysical analysis. 
  • Extensive expertise in setting up and optimising vapour diffusion crystallisation experiments.
  • Experience in fragment screening approaches, including crystallographic fragment screening.
  • Expertise in collecting and processing X-ray diffraction data from various synchrotron sources across the world.
  • Ability to solve and refine crystallographic structures including expertise in using CCP4, Global Phasing and Phenix crystallographic software suites.
  • Deep understanding of SM / NCE ligand chemical restraint definition and subsequent ligand co-structure refinement.
  • Demonstrated proficiency in shell scripting and experience in developing pipelines to handle large scale diffraction data processing.
  • Experience with PanDDA approaches for data processing would be beneficial.
  • Proven track record in presenting results (both written and verbal) to internal and external audiences.

What is on Offer

  • The chance to work in a highly collaborative, progressive and intellectually stimulating environment, applying state of the art AI-based techniques to revolutionise drug discovery.
  • Excellent base salaries offered with regular appraisals and reviews.
  • Share options in CHARM Therapeutics through the EMI scheme.
  • Vitality Healthcare, including dental and optical.
  • Gym membership through ‘Better Gym’.
  • Budget for employee development; training courses and conferences.
  • Top of the range Macbook pro and any necessary equipment fully expensed.
  • Fruit and snacks delivered to our offices.
  • Regular team social events.


[Post Date: April 21, 2022]


Director, Head of Biochemistry at CHARM Therapeutics, Cambridge, United Kingdom

View the Job Posting Here

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Description:

CHARM Therapeutics is a biotech company focused on delivering transformational medicines that will address difficult-to-drug targets in key oncogenic pathways.

CHARM has developed the first highly accurate, high throughput protein-ligand co-folding algorithm (DragonFold), driven by end-to-end 3D deep learning. Our platform enables the rapid generation of highly differentiated clinical candidates, and our ambition is to revolutionise drug discovery. 

CHARM Therapeutics is establishing a state-of-the-art R&D facility in Cambridge, UK.  We are seeking an exceptional biochemist with a passion for scientific innovation to lead our biochemistry group. The successful candidate will join a multidisciplinary, highly collaborative discovery team to invent novel medicines and drive them towards the clinic. 

Role

We are currently seeking an exceptional biochemist to join the structural sciences group at CHARM Therapeutics, establishing and then leading a lab-based team working on high throughput crystallographic and CryoEM structural targets to fully enable and drive multiple SBDD / Med Chem campaigns.

Requirements

The successful candidate will be expected to meet the following criteria:

  • A PhD level qualification in protein biochemistry or a related discipline, is required.
  • A minimum of eight years experience in an industrial / biotech setting and previous team leadership is preferred.
  • Extensive experience and drive in the application of precision protein biochemistry to all aspects of drug discovery programs including structural biology and generating / interpreting QC / functional data in terms of MS, SPR, ITC, etc.
  • Excellent molecular biology / cloning / protein engineering skills and knowledgeable in expression construct design, and all types of downstream purification strategies.
  • Extensive practical experience and expertise in the expression and purification of multiple target proteins from recombinant systems (both bacterial and eukaryotic) utilising e.g. cutting edge 3rd Gen affinity systems, for targets specifically in oncology, alongside higher molecular weight complexes and integral membrane proteins for structural and biophysical analysis.
  • Demonstrable track record and deep knowledge of leading a group that routinely produces large scale protein preparations with targets purified to homogeneity across numerous FPLC systems - while leveraging multiple expression sources including bacterial, insect cell and mammalian suspension cell culture – with resultant samples subsequently being deployed across an array of discovery applications.
  • Ability to direct and manage a large group of scientists efficiently and effectively.
  • Excellent management and interpersonal skills.
  • Proven track record in presenting results (both written and verbal) to internal and external audiences.

What we offer 

  • Private Medical Insurance, incl. dental & mental cover
  • Competitive pension scheme
  • Gym membership
  • Weekly office lunch
  • Office fruits & snacks
  • Regular socials


[Post Date: April 21, 2022]


Senior Scientist I, Physical Chemistry

View the Job Posting Here

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Description:

The Protein Crystallography Group at AbbVie Headquarters in Lake County, Illinois is seeking a highly motivated scientist to join our Structure-Based Drug Discovery team. The ideal candidate should have extensive hands-on experience in modern X-ray Crystallography techniques and computational methods of molecular structure analysis. As part of multidisciplinary teams, the Scientist will utilize fragment-based strategies to identify ligands and provide insight to advance drug discovery targets through structure-based design. The successful candidate will contribute to drug discovery projects across the portfolio of AbbVie interests that also include therapeutic antibodies and novel biologics.

Key Responsibilities:

  • Determine X-ray crystal structures of protein-ligand complexes in high throughput modes and identify strategies for improved molecular designs.
  • Provide guidance to crystallization and protein construct design efforts for useful sample preparations
  • Utilize cheminformatics tools and manipulate scripts for use across mixed computing platforms
  • Interact with members of Fragment-based Drug Discovery team to advance hit to lead projects
  • Work with biologists, molecular modelers, and medicinal chemists to validate targets of interest
  • Maintain accurate and timely records of experimental results
  • Communicate results and interpretative analysis to project teams, and present at internal meetings
  • Publish in peer-reviewed journals as appropriate and present at external scientific meetings
  • Evaluate the scientific literature critically and adopt novel technologies which will facilitate structure-based drug discovery at AbbVie

Qualifications:

  • PhD in Chemistry, Biochemistry, Biophysics, or a related field
  • 3+ years of relevant academic or industry experience is required
  • Proven ability in protein crystallization and crystal structure analysis with X-ray or cryo-EM/Electron Diffraction data
  • Familiarity with structure-based drug design strategies and fragment based approaches
  • Experience in complementary techniques of macromolecular SAXS analysis or cryo-EM is desirable
  • Must be detail oriented and meticulous regarding documentation and data management
  • Ability to work both independently and as part of a highly collaborative, interdisciplinary team
  • Effective written and verbal communication skills
  • Ability to work on multiple projects in parallel and rapidly adjust to changing priorities


[Post Date: April 20, 2022]


Postdoc Berlin - HZB and Humboldt University

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Description:


The Helmholtz Zentrum Berlin für Materialien und Energie, the Max-Delbrück-Center for Molecular Medicine, the Freie Universität Berlin, the Charite, the Max-Planck-Institute for Colloids and Interfaces  and the Humboldt Universität zu Berlin jointly operate three experimental stations for bio-macromolecular crystallography at BESSY II, Berlin's modern synchrotron radiation source, located in the lovely southeast of Berlin.

(https://www.helmholtz-berlin.de/forschung/oe/ps/macromolecular-crystallography/index_en.html)

The Humboldt University zu Berlin is seeking a Post Doctoral Research Assistant.

to work on and support research topics in the field of structural enzymology (e.g. control of chemical reactions in macromolecular crystals, combination of UV/Vis absorption spectroscopy and crystallography, etc.) originating from the group of Prof. Dr. Holger Dobbek. The successful candidate will also be involved in the operation of the BESSY II bio-macromolecular crystallography beamlines (headed by Dr. Manfred S. Weiss) including supporting external users at the beamlines and will take part in graduate student education.

Initially,  a contract lasting until 31.12.2023 will be offered to the successful candidate with the possibility for an extension. The salary will be based on German Federal TVöD. The position is available immediately.

Applicants should hold a Ph.D. in the biological, chemical or physical sciences and have a solid background in biochemical methods, in bio-macromolecular crystallography and/or related fields. The position also requires the documented ability to conduct independent research as well as excellent communication and interpersonal skills.  

Please send applications (CV, list of publications, references, .pdf-file format) citing the reference number AN/073/22 in electronic form until 28.04.2022 to:

Dr. Manfred Weiss (msweiss@helmholtz-berlin.de


[Post Date: April 20, 2022]


Research Opportunities in the Li Lab

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Description:

Postdoctoral Positions:

Postdoctoral positions are available in Dr. Fang Li's lab at the Department of Veterinary and Biomedical Sciences, University of Minnesota Twin Cities. We conduct research on biochemical mechanisms of coronaviruses and develop drugs and vaccines. Candidates should have a PhD in molecular biology, biochemistry, virology, or a related field. Salary is at NIH rates. To apply, please send a statement of research interest and CV to lifang@umn.edu, and arrange 2 letters of recommendation to be sent directly to Dr. Li. More information about Dr. Li's lab can be found at http://www.msi.umn.edu/~lifang.

Researcher Positions:

Researcher positions (Researcher 1-3) are available in Dr. Fang Li's lab. Candidates must have a bachelor's or master's degree in biology or a related field and have experience in molecular cloning, cell culture, and protein purification. To apply, please send a statement of research interest and CV to lifang@umn.edu, and arrange 2 letters of recommendation to be sent directly to Dr. Li.

Ph.D. Positions:

Ph.D. positions are available in Dr. Fang Li's lab. Candidates should be highly motivated about scientific research, have a major in biochemistry, microbiology or a related field, and meet requirements for one of the following departmental admissions: Veterinary Medicine, Biochemistry, Microbiology, or Pharmacology.

Undergraduate Research Opportunities:

U of M students interested in conducting research in Dr. Fang Li's lab may sign up for a directed research course offered by the student's college (https://ugresearch.umn.edu/opportunities/directed-study).

Those who wish to be supported by UROP funding (https://ugresearch.umn.edu) should contact Dr. Li to discuss the research project at least two weeks before one of the UROP deadlines.

Also see details at https://www.msi.umn.edu/~lifang/fljobopenings.html

Please contact Dr. Fang Li at lifang@umn.edu, if you are interested.


[Post Date: April 20, 2022]


Postdoc Position at the Department of Biochemistry and Redox Biology Center, the University of Nebraska-Lincoln

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Description:

A postdoc position is available in Dr. Limei Zhang’s group at the Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, for highly motivated candidates who are interested in structural biology, redox biology and infectious disease. The position will offer a competitive salary and benefits.

Zhang Group: With funding support from both NIH and NSF, the Zhang Group applies a suite of interdisciplinary tools to investigate the structure-mechanism relationships of metalloproteins in redox reactions, stress responses and antibiotic resistance. For more information about the Zhang Group, please visit the website: https://biochem.unl.edu/limei-zhang.

Job responsibilities: The postdoctoral fellow is expected to independently design and conduct high-quality research experiments for the assigned project under the supervisor’s guidance; analyze data and draft manuscripts for publication; take roles in the lab maintenance with other group members; and assist the supervisor to mentor undergraduate and graduate students.

Qualifications: The required qualifications include a recent Ph.D. degree (or expected soon) in biochemistry, biophysics, chemistry, microbiology or a related field; a strong record in conducting high-quality research in protein biochemistry or biophysics. Experience in structural biology (X-ray crystallography, cryo-EM or nuclear magnetic resonance) is highly desirable but not required.

Training: The postdoc fellow will have the opportunity to learn comprehensive methods for preparation and characterization of metalloproteins in the Zhang group and the first-hand training in cryo-EM in the collaborating research center supported by the NSF EPSCoR Research Fellowship.

The University of Nebraska-Lincoln is located in a vibrant and safe city offering an outstanding and affordable quality of life, and numerous multi-cultural and entertainment benefits. The Redox Biology Center is organized as a broad-based interdisciplinary and multi-institutional entity involving researchers from the University of Nebraska-Lincoln and the University of Nebraska Medical Center in Omaha and offers a supportive and collaborative international environment as well as access to cutting edge proteomics, metabolomics, crystallography, and NMR facilities. We are also expected to have a cryo-EM instrument (Glacios w/Falcon 4i, Selectris EF & Ceta-D camera) installed at UNL in late 2022.

Recognizing that diversity within a context of inclusivity enhances creativity, innovation, impact, and a sense of belonging, the Institute of Agriculture and Natural Resources (IANR) and the Department of Biochemistry are committed to creating learning, research, Extension programming, and work environments that are inclusive of all forms of human diversity. We actively encourage applications from and nominations of individuals from underrepresented groups.

To apply for the position, please submit a letter of interest with a short summary of past research experience; your curriculum vitae, and contact information for three professional references, including phone numbers and emails to limei.zhang@unl.edu


[Post Date: April 20, 2022]


Crystallography Scientist position in FischerLab at St Jude

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Description:

The Fischer lab at St. Jude is recruiting a Scientist for a project that exploits the protein conformational landscape for ligand discovery in pediatric cancer. We are looking for applicants with a strong training in the gene-to-structure pipeline, including molecular biology, protein biochemistry, and structural biology (especially crystallography) and a keen interest or ideally experience in ligand discovery.

You will be part of an interdisciplinary team that uses modern structural biology (variable temperature crystallography) to characterize disease-relevant protein states, computational methods (MD, docking, custom software) to analyze and exploit them, and experiments (biophysical, biochemical, cell-based assays) to test the impact of small molecules on biology and disease. These approaches are also relevant for allosteric regulation of proteins and protein-protein interactions. 

The successful candidate will have these attributes:

1) Must be able to conduct independent research in molecular biology and protein biochemistry, including cloning and protein purification, that enable structural studies.

2) Demonstrated experience in protein crystallography (from crystallization to data collection to refinement, analysis and deposition)

3) Familiarity with large-scale/ high-throughput approaches, automation, liquid handling, biophysical/ biochemical assays or computational approaches is desirable.

4) Experience with expression systems other than E. coli is a plus such as insect cells.

5) Proficiency in e.g. python or shell scripting will facilitate scaling up data analysis.

6) Must be eager to learn and implement new techniques from relevant areas. 

Besides working on your own projects, you will be a liaison for other lab members and support projects within the lab while maintaining efficient laboratory operations.

Our group is housed in the Department of Chemical Biology and Therapeutics, and Structural Biology at St. Jude Children’s Research Hospital. With ongoing investments into exceptional structural and chemical biology facilities, this is an exciting time to join our lab to do cutting-edge research whilst living in an affordable city. Stable funding for this post is available.

Relevant papers include:

  • Bradford et al. (2021). Temperature artifacts in protein structures bias ligand-binding predictions. Chemical Science 12, 11275-11293.
  • Fischer (2021). Macromolecular room temperature crystallography. Q Rev Biophys 54, E1.
  • Darby et al. (2019). Water Networks Can Determine the Affinity of Ligand Binding to Proteins. JACS 141, 15818-26.
  • Balius et al. (2017). Testing inhomogeneous solvation theory in structure-based ligand discovery. PNAS E6839-46.
  • Fischer et al. (2015). One crystal, two temperatures: cryocooling penalties alter ligand binding to transient protein sites. Chembiochem 16, 1560-64.
  • Fischer et al. (2014). Incorporation of protein flexibility & conformational energy penalties in docking screens to improve ligand discovery. Nature Chemistry 6, 575-83.

More info at: https://www.stjude.org/fischer

Minimum Education

  • Bachelor's degree in relevant scientific area is required.

Minimum Experience

Scientist

  • Seven (7) years of relevant post-degree work experience is required.
  • Five (5) years of relevant post-degree work experience is required with a Master's degree.
  • Three (3) years of relevant post-degree work experience is required with a PhD.

Lead Researcher

  • Five (5) years of relevant, post-degree work experience is required with a Bachelor's degree.
  • Two (2) years of relevant post-degree work experience is required with a Master's degree.
  • No experience is required with a PhD degree.


[Post Date: April 18, 2022]


Postdoc University of California Riverside

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Description:

Position Description: A post-doctoral position is immediately available for highly motivated, hard-working candidates to join Dr. Jikui Song’s group in the Department of Biochemistry at University of California, Riverside. Dr. Song’s research group employs collaborative and multidisciplinary approaches to investigate mechanistic basis of cancer epigenetics, in particular chromatin modifications that are essential for gene regulation and development. We are also exploring the mechanistic basis and regulatory mechanisms of viral replication, toward identification of effective therapeutical strategies against viral infection. The project will involve structural and dynamic characterization of macromolecular complexes using cryo-EM, X-ray crystallography, single-molecule FRET and other biochemical/biophysical approaches. Examples for recent publications include Zhang et al. Nature (2018) 554:387-391, Wang et al. Nat. Struct. Mol. Biol. (2020) 27: 875-885, Gao et al. Nat. Commun. (2020) 11:3355, and Ren et al. Nat. Commun. (2021) 12:2490.

Research Environment: The NIH-funded research in the Song lab aims to uncover the fundamental principles underlying epigenetic regulation and pathogen-host interaction. The successful candidates will have extensive opportunities for multiple collaborations with scientists at UC Riverside and worldwide. UC Riverside is located at the metropolitan area of Los Angeles. Such an environment allows one to have a good balance of life and science.

Qualification and Experience: Successful candidates will have a recent PhD in structural biology, biophysics or other related fields, with extensive experience in protein production, biochemical characterization and structural analysis. Additional background in cryo-EM is highly desirable. Applications will be reviewed as they are received. The position will remain open until filled. Postdoctoral salary will be commensurate with prior research experience and qualifications.

Application: Interested applicants should send curriculum vitae, expected starting date, brief summary of previous research experience, and contact information of 2-3 references as one single PDF file to Jikui Song, Ph.D. Department of Biochemistry, University of California, Riverside, CA 92521 (Email: jikui.song@ucr.edu).

More information can be found in https://songlab.ucr.edu.


[Post Date: April 14, 2022]


Structural Biology Investigator

View the Job Posting Here

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Description:

Job description

Site Name: USA - Pennsylvania - Upper Providence
Posted Date: Apr 12 2022

Are you energized by a highly collaborative scientific role in drug discovery that allows you to impact scientific strategy and accelerate R&D delivery? If so, this role could be an ideal opportunity to explore.

An exciting opportunity is available within Structural and Biophysical Sciences, which is part of Medicine Design at the GSK US R&D hub in Upper Providence, Pennsylvania. GSK is seeking a highly motivated and creative structural biologist to impact drug discovery programs through delivery of high-resolution structural data and integration of structural data with results from partnering groups. Our department combines structural biology with biophysical data to understand and optimize interactions between drug targets and small molecule hits, leads, and candidates to support discovery across all therapeutic areas under investigation at GSK. Our group interacts broadly with project teams consisting of biologists, medicinal chemists, biochemists, and computational chemists to discover and optimize novel therapeutics. This position requires excellent communication, organizational, and interpersonal skills and the ability to influence diverse drug discovery teams using robust science.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

  • Solve x-ray crystal structures from in house and synchrotron diffraction data sources using molecular replacement and experimental phasing methods for protein:ligand, protein:protein, and protein:nucleic acid complexes.
  • Initiate structural biology on new programs by working with computational and biochemical scientists to design protein constructs and build comprehensive plans to yield structural data relevant to the discovery campaigns.
  • Carefully design and carry out experiments to integrate structural and biophysical mechanisms to generate actionable information for the advancement of drug discovery campaigns.
  • Characterize purified protein drug targets and protein:ligand interactions using biophysical methods.
  • Prepare research reports, give internal and external presentations, champion and contribute to publications.
  • Maintain current knowledge of structural biology literature to keep abreast of new technologies well suited for drug discovery and the GSK R&D strategy.
  • Implement creative new methods, protocols, and technologies to advance the efficiency, speed, and success-rate of structural biology techniques for complex systems.
  • Interact with business partners including therapeutic-area focused research units, biophysicists, medicinal chemists, and counterpart technology groups. Liaise and consult as a representative to program teams.

Why You?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • A Ph.D. in Structural Biology, Biophysics, Biochemistry, Chemistry, Chemical Biology or related field, plus 2 years of post-doc experience or a BS/MS with 5 + years relevant industry experience in a related discipline

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Deep understanding and demonstrated expertise in x-ray crystallography and protein crystallization with a strong knowledge of biophysics and biochemistry.
  • Strong track record of publications in peer reviewed journals.
  • Linux system management, data pipelines and automation of data analysis, scripting/coding, x-ray facility management, and high performance computing.
  • Cryo-EM grid preparation, data collection, or data processing/analysis for protein structure determination.
  • Biophysical methods including surface plasmon resonance (SPR), microscale thermophoresis (MST), or nuclear magnetic resonance (NMR). Experience with quantitative protein biophysics and molecular interaction analysis.
  • Demonstrated strengths in high performance behaviors, such as building relationships, flexible thinking, and enabling/driving change.

Why GSK? 

At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we’re making the biggest changes we’ve made to our business in over 20 years. We’re on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands.

With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together – all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive.

Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients – so we deliver what matters better and faster; accountable for impact – with clear ownership of goals and support to succeed; and where we do the right thing. So, if you’re ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together.


[Post Date: April 12, 2022]


Research Scientist/Postdoc position- Institute of Molecular Medicine Center Translational Cancer Research of UTHealth at Houston

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Description:

Our group (Institute of Molecular Medicine - Center for Translational Cancer Research of UTHealth at Houston)  is looking to hire a research scientist/postdoc immediately with experience in protein chemistry, protein engineering, and/or Bioconjugation.

Our group is working on developing novel antibody-drug conjugates (ADCs) for effective cancer treatment. For more information, please visit: https://www.uth.edu/imm/faculty/profile?id=0474c506-9d8e-488b-8295-083ec70fb688

The candidate for this position will be highly motivated to lead and perform characterization and development studies on ADCs. This will include protein expression, purification, and conjugation reaction. In addition, the candidate will design and execution of development studies to identify and determine appropriate conditions for producing several types of ADCs.

Successful candidates should have a Ph.D. in Biochemistry, Biophysics, Chemistry, Pharmaceutical Science, or a related field. Experience in the production, purification, and characterization of protein on a research scale is required. Demonstrate excellent communication and writing skills.

Interested candidates, please send a CV and a brief statement of interest, and contact information for three references to Dr. Qingyun Liu (Qingyun.Liu@uth.tmc.edu) or Dr. Yukimatsu Toh (Yukimatsu.Toh@uth.tmc.edu)

University of Texas Health Science Center at Houston (UTHealth) Established in 1972 by The University of Texas System Board of Regents, The University of Texas Health Science Center at Houston (UTHealth) is Houston’s Health University and Texas’ resource for health care education, innovation, scientific discovery, and excellence in patient care. The most comprehensive academic health center in the UT System and the U.S. Gulf Coast region, UTHealth is home to schools of biomedical informatics, biomedical sciences, dentistry, nursing, and public health, and the John P. and Kathrine G. McGovern Medical School. UTHealth includes The University of Texas Harris County Psychiatric Center, as well as the growing clinical practices UT Physicians, UT Dentists and UT Health Services. The university’s primary teaching hospitals are Memorial Hermann-Texas Medical Center, Children’s Memorial Hermann Hospital and Harris Health Lyndon B. Johnson Hospital.


[Post Date: April 12, 2022]


Postdoc in Structural Biology Uniformed Services University of the Health Sciences (USU), Bethesda, Maryland

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Description:

A postdoctoral position is available immediately to participate in an inter-disciplinary research program in structural immunology at the laboratory of Dr. Pazgier (https://www.usuhs.edu/node/68252) at Uniformed Services University of the Health Sciences (USU), Bethesda, MD

Candidates are expected to work on ongoing research projects in structural biology with the aim to understand the molecular basis of the adaptive immune response to HIV-1 and Sars-Cov2 and the ultimate goal to develop new protein-based therapeutics and novel vaccine concepts. Qualifications for the position include: a strong research interest and experience in molecular cloning, protein expression, molecular interaction analysis, X-ray crystallography and/or Cryo-EM and excellent interpersonal/oral/written communication skills.

Candidates need to be highly motivated individuals who enjoy working as part of a dynamic, collaborative and multidisciplinary team. Preference will be given to candidates with exceptionally strong experimental skills, a strong record of peer-reviewed publications, and a demonstrated commitment to basic research. Qualified candidates should have a doctorate in chemistry/biochemistry, microbiology, immunology or a closely-related field. Candidates at any career stage are invited.

USU is in Bethesda, MD directly across the street from the NIH, and is therefore part of an extraordinarily vibrant local biomedical research community. Our research projects take advantage of recently established Core facilities for Nextgen sequencing, Bioinformatics and Structural Biology analyses. USU has a strongly collaborative environment, with weekly Immunology data club and journal club meetings, as well as regular research seminars featuring local and invited speakers.

Candidates should apply to Dr. Pazgier directly at marzena.pazgier@usuhs.edu


[Post Date: April 7, 2022]


Postdoc Rice University

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Description:

A postdoctoral position is available in Dr. Yang Gao’s Lab (http://yanggaolab.blogs.rice.edu/) at Rice University, Houston, TX. Our lab studies enzymes and motors in DNA replication and repair (Science 363 (6429), eaav7003; Science 352 (6291), 1334). We combined biochemical, and biophysical techniques with cryo-electron microscope and crystallography to investigate how the genomic DNA is replicated and maintained. In addition, we explore structural-based drug screening (PMID: 34900730) and protein engineering (Yang, et. al. under revision, Nat. Chem. Biol.). Previous experiences with protein cloning, expression, and purifications are needed. Experiences in crystallography and cryo-EM are a plus but not stickily required. Candidates with experience in biochemical reconstitution and characterizations of large enzyme complexes are more than welcome.  Interested candidates please contact Yang at yg60@rice.edu for details.


[Post Date: April 5, 2022]


Postdoc NIH

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Description:

There is an open postdoctoral position in my lab. We are interested in the structure and function of  integral membrane enzymes that catalyze protein lipidation (Science, 2018, 359, eaao6326; PNAS., 2022 Feb 15;119(7):e2022050119) and transporters of transition metal ions (J Biol Chem. 2018;293(10):3819-3828; PNAS, 2019,116,17775-17785).  We combine structural techniques such as cryoEM and macromolecular crystallography with biophysical and biochemical methods such as reconstitution based assays, high resolution light microscopy and small molecule screening to ask mechanistic questions. We are also increasingly becoming invested in structure inspired cell biological questions.

The candidates should hold a Ph.D. degree, be author of at least one first author publication and have a strong background in biochemistry or structural biology. Experience with basic molecular biology, protein expression, purification and biochemical characterization are required. Prior experience in membrane protein biochemistry or cryoEM will be added advantages.

Interested candidates can send an e-mail to anirban.banerjee@nih.gov with a CV and a summary of previous research experience and future interests.

The NIH is dedicated to building a diverse community in its training and employment programs.

Please help spread the word to interested candidates.


[Post Date: April 5, 2022]


Postdoc MPI NAT Goettingen

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Description:

Max Planck Institute for Multidisciplinary Sciences, Göttingen/Germany

The Max Planck Institute for Multidisciplinary Sciences in Göttingen is an internationally leading research institute of exceptional scientific breadth. The largest institute of the Max Planck Society, it comprises more than 40 research groups and employs around 1,000 people from over 50 nations.

The research group Ubiquitin Signaling Specificity (Dr. Sonja Lorenz) invites applications for a position as

Postdoc (f/m/d) – Cell biology of ubiquitin ligase complexes –

Our lab aims to understand how ubiquitin − a single, small protein − achieves specificity in regulating virtually all aspects of eukaryotic cell biology. A major key lies in the action of ubiquitin ligases, the most diversified class of enzymes of the ubiquitin system. The immense potential of ubiquitin ligases as therapeutic targets is illustrated by the clinical efficacy of thalidomide and derivatives in the treatment of hematologic malignancies. However, progress towards rationally manipulating these enzymes has been impeded largely by our insufficient understanding of their integration into macromolecular complexes and the associated structural and functional consequences. We aim to identify and characterize macromolecular complexes of ubiquitin ligases to decipher the molecular basis of their specificities in substrate recognition and ubiquitin chain formation. To this end, we combine chemical-biological, biochemical, cell biological, and structural approaches with a particular focus on cryo-electron microscopy.

We have a fully-funded postdoc position available for a talented individual to uncover cellular ubiquitin ligase assemblies implicated in neurodevelopmental disorders.

Your profile:

You have a PhD or equivalent degree in a relevant subject area, such as cell and molecular biology, biochemistry or biomedicine.
You have a proven track record in molecular cloning and cell biology, specifically in one or more of the following techniques: Crispr/Cas9-mediated gene editing, RNA interference, cell fractionation, co-IP, immunofluorescence, and live-cell imaging.
Additional experience in neuronal cell culture and/or proteomics will be beneficial.
You are curiosity-driven and eager to interact with biochemists and structural biologists.
 You are passionate about science and keen to establish creative new approaches to tackle challenging protein complexes.
You are self-motivated and independent, and enjoy being part of an international, multidisciplinary team.

About us:

We are an independent research group at the Max Planck Institute for Multidisciplinary Sciences, one of Germany’s premier research campuses with leading-edge infracture in all fields of structural and cell biology. We are a highly international and interdisciplinary team, funded by the Max Planck Society, the German Research foundation, and the EMBO YIP. The historic city of Goettingen, located in the center of Germany, offers great outdoor and cultural opportunities, a bustling student scene, and an impressive scientific heritage.

Position details:

The position should be filled as soon as possible, but the exact start date is flexible. The position is initially for 2 years with the possibility of extension. Payment and benefits are based on the TVöD guidelines.

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds.

Application:

Please submit your application including cover letter (explaining background and motivation), CV, transcripts, and publication record by e-mail as a single PDF file to the email address below. Review of applications will begin immediate. Informal inquiries are also welcome.

ausschreibung26-21@mpibpc.mpg.de


[Post Date: April 5, 2022]


Postdoctoral Research Associate position in Structural Virology

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Description:

Within the framework of the Collaborative Research Center 900 and the ‘COVID-19 Forschungsnetzwerk Niedersachsen’ (COFoNi) we invite applications for a Postdoctoral Research Associate to work in the group of Thomas Krey, Institute of Biochemistry at the Universität zu Lübeck (UzL; Germany). We are mainly interested in the biochemical and structural characterization of viral glycoproteins and their roles during the viral replication cycle (mainly virus entry and interaction with the host’s immune system). The major scientific focus will be initially the glycoproteins of the Hepatitis C virus and the β-Coronavirus spike protein. The project will actively build on our previous experience with the structural and functional characterization of glycoproteins (e.g., Fedry et al., Cell, 2017; Fedry et al., PLoS Biol, 2018; Krey et al., PLoS Path, 2013; Meola et al., J Virol, 2015; Vasiliauskaite et al., mBio, 2017).

The position is available for an initial period of 19 months with a possibility to be extended.

We:

  • Are fascinated by viral glycoproteins and their interactions with neutralizing antibodies
  • Are structural biologists with a special interest in immune profiling of human antibody repertoires and single cell sequencing of human B cells
  • Use a wide range of methodologies including but not limited to protein biochemistry, X-ray crystallography, cryo electron microscopy and single cell Next Generation Sequencing (NGS)
  • Offer state-of-the-art equipment in protein expression, purification and crystallization
  • Provide an international, interdisciplinary, exciting and stimulating scientific environment at the UzL
  • Have access to

- Ample beamtime at third generation synchrotron X-ray sources

- The cryo-EM facility at CSSB Hamburg with high-end cryo electron microscopes

- A state-of-the-art FACS facility on-campus with single-cell sequencing instrumentation

- Excellent biophysical instrumentation (Surface Plasmon resonance, SEC-MALLS, Nanoliterplate based DLS, ITC)

You:

  • Have a PhD in structural biology, biochemistry, virology or a related scientific area
  • Are interested in neutralizing antibodies either as therapeutic tool or as basis for informed vaccine design
  • Have experience in protein purification, structural biology techniques (preferably X-ray      crystallography), antibody biology or immune repertoire profiling
  • Enjoy working both on your own and as part of an international and interdisciplinary team
  • Like to visit international conferences and present your data
  • Are a creative and enthusiastic individual committed to solve problems

Please send a cover letter, CV, relevant certificates as well as names, e-mail addresses and telephone numbers of at least two references in a single PDF to Thomas Krey (krey.thomas@mh-hannover.de). Additional information can be provided upon request.


[Post Date: April 5, 2022]


Postdoctoral Fellow position at University of Texas Health Science Center San Antonio

View the Job Posting Here

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Description:

The laboratory of Dr. Yogesh Gupta at the University of Texas Health at San Antonio is seeking an enthusiastic Postdoctoral Fellow to study the structures and functions of mRNA modification and chromatin remodeling complexes. We use structural biology (X-ray, NMR, cryo-EM) and cell-based methods to address basic mechanistic questions and use this knowledge to develop small molecule antagonists and antibody-based therapies. The laboratory provides a rich multi-disciplinary training environment and access to cutting-edge technologies in drug development.

Further details of our most recent work can be found here:

  1. Nature Communications. 2021 Jun 2; 12: 3287. PMID: 34078893. doi: 10.1038/s41467-021-23594-y
  2. Nature Communications. 2020 Jul 24;11(1):3718. PMID: 32709886. doi: 10.1038/s41467-020-17496-8

Preference will be given to applicants with demonstrated experience in protein purification from insect/mammalian cells, protein-nucleic acid biochemistry, and X-ray crystallography or cryo-EM. Prior experience with antibody engineering and structure determination is a plus. Candidates are expected to possess strong organizational, interpersonal skills, and the ability to work independently but also effectively and collaboratively as part of a team. An ideal candidate should hold (or soon expect to hold) a Ph.D. or equivalent degree in a related discipline and have no more than 2 years of postdoc experience.

The Greehey Children’s Cancer Research Institute (GCCRI) is a unique specialized cancer research center focusing on basic and translational research in childhood cancer and occupies a state-of-the-art 100,000 sq. foot research facility on the university’s Greehey Academic and Research Campus. The GCCRI has significant external funding, a large endowment from the state, and links to philanthropic entities.

San Antonio is the nation’s seventh-largest city and is located at the edge of the beautiful Texas Hill County. San Antonio offers a rich, multi-cultural community, affordable cost of living, excellent weather, and a thriving biomedical industry.

Salary is competitive and commensurate with experience. San Antonio offers an affordable cost of living and there is no state income tax in Texas.

How to Apply

If interested in applying, please send a short description of your research accomplishments and a CV with contact information of 3 references to Dr. Yogesh Gupta (email: guptay@uthscsa.edu).

All Postdoctoral appointments are designated as security-sensitive positions. UT Health San Antonio is an Equal Opportunity/Affirmative Action Employer including protected veterans and persons with disabilities.


[Post Date: April 5, 2022]


Postdoc Institute for Structural Biology, Grenoble

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Description:

Postdoctoral position on scaffold protein assemblies in MAPK cell signalling

A 2-year postdoctoral position (with possible extension) is available from the 1st of June 2022 in the team of Dr. Malene R. Jensen at the Institute for Structural Biology (IBS) in Grenoble, France. The successful candidate will work on the structure and dynamics of scaffold proteins and study their interactions with kinases of the mitogen-activated protein kinase (MAPK) cell signalling pathways. We exploit a combination of X-ray crystallography and NMR spectroscopy. 

More information can be found on the team website: www.jensen-nmr.fr


Facilities
The Institute for Structural Biology is located on the EPN science campus in Grenoble in close proximity to the European Synchrotron Radiation Facility (ESRF), the European Molecular Biology Laboratory (EMBL) Grenoble Outstation and the Institute Laue-Langevin (ILL). The IBS houses six high-field NMR spectrometers (3 x 600, 700, 850 and 950 MHz) and wetlab facilities for cloning, expression and purification of proteins. Access is facilitated to a number of state-of-the-art research platforms through Integrated Structural Biology Grenoble.

Qualifications
The ideal candidate holds a PhD in chemistry, biochemistry or biophysics (or related discipline) and has experience in protein expression and purification and a proven track-record in solution NMR spectroscopy and/or X-ray crystallography. To apply for this position, please send your CV, a motivation letter and the names of two referees to malene.ringkjobing-jensen@ibs.fr


[Post Date: March 30, 2022]


Postdoc & Technician Positions Brown University

View the Job Posting Here

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Description:

The Deaconescu Lab at Brown University has two openings for  postdoctoral researchers and one for a technician. The laboratory's interests lie primarily in stress responses, with particular emphasis on responses to DNA damage. We utilize a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, electron microscopy). Examples of recent work are: Schwartz et al, Protein Science (2021), Brugger et al, Nature Communications (2020), Dorich et al, Genes & Development (2019), Vemu et al. Science (2018), Le TT et al. Cell (2018), Szyk et al, Cell (2014). Positions are funded by two new multi-year grants from the NIH.

A successful postdoctoral candidate should have an established track-record of publications in peer-reviewed journals; solid experience with protein biochemistry (their purification and assay development). We have a variety of projects available at different stages of development, including some that involve drug design. Prior knowledge of crystallography and/or single-particle electron microscopy is highly desirable. Must be highly motivated and work well independently as well as in a team. Excellent spoken and written English are required. Newly minted PhDs are encouraged to apply.

A successful technician candidate should preferably have  a degree in chemistry/biological sciences and more than two years experience at the bench, at the minimum experience with molecular biology, and ideally, also with protein purification and crystallization.

Interested candidates should send a CV, a one page research experience summary and contact information for three references to alexandra_deaconescu[at]brown.edu. Please use “postdoctoral candidate” or “technician candidate" as a subject.

Salary and starting date are negotiable. Brown University, an Ivy League school ranked as 5th best in the US by the Wall Street Journal, is located in Providence, Rhode Island less than one hour away by train from Boston.   Rhode Island provides plenty of opportunities for outdoor recreation with beautiful beaches and sailing and we offer a friendly and supportive lab environment.


[Post Date: March 30, 2022]