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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Research Scientist I - Structural Biology

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Description:

Embedded within the Broad Institute, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional “drug hunters”.  Our mission is to translate cutting edge biological insights originating from the Broad community into impactful drug discovery projects. In executing this mission we bring together faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry partners in venture capital, biotechnology, and pharmaceutical companies.

We combine our deep expertise in drug discovery with the knowledge and unique capabilities of the Broad Institute to address a wide range of disease areas including oncology, cardiovascular disease and diabetes, psychiatric disease, infectious disease, and rare diseases.  Our goal is to embrace Broad's culture of creativity and open sharing to de-risk therapeutic hypotheses, validate new targets, and advance new therapies that will improve human health globally.  

OVERALL RESPONSIBILITY

The Broad Institute is in search of a highly motivated and capable Research Scientist to join the Center for the Development of Therapeutics (CDoT). CDoT is committed to developing and applying novel drug discovery approaches and technologies to address critical unmet medical needs not being tackled elsewhere.  The successful candidate will share this commitment and be part of a multidisciplinary team that drives innovation to solve therapeutic challenges.

The primary role of this position is to provide structural biology support for various drug discovery projects.  The successful candidate will have significant interest and experience in the crystallization of proteins and protein-ligand complexes for the purpose of X-ray diffraction and subsequent structure elucidation.  Importantly, given our multidisciplinary project team approach to drug discovery, the successful candidate will also need to thrive in a collaborative team environment.

ROLE-SPECIFIC RESPONSIBILITIES

  • Crystallize protein targets alone and in complex with ligands:

    • Screen for, and identify protein crystallization conditions

    • Optimize crystallization and diffraction of hits

    • Employ automated technologies to achieve the above (Mosquito, Rockmaker/RockImagers, Formulator)

  • Devise and implement robust protocols for the routine soaking or co-crystallization of ligands

  • Prepare and freeze protein crystals for shipping and remote data collection

  • Work collaboratively with colleagues in protein sciences, biophysics, computational chemistry, medicinal chemistry, and other disciplines in support of structure-based drug design

GENERAL RESPONSIBILITIES

In the day-to-day execution of his/her science, it is expected that the successful candidate will:

  • Initiate and complete routine procedures independently and efficiently

  • Interpret experimental outcomes and proposing next steps

  • Troubleshoot technical and scientific problems

  • Operate and maintain laboratory equipment independently

  • Document work and effectively present results

QUALIFICATIONS

  • Core qualifications:

    • Masters or PhD in Structural Biology, Biophysics, Biochemistry or a related life science field with 0 - 2 years of post-degree research experience in an industrial or academic setting

    • Hands-on experience crystallizing protein targets

    • A proven record of successful interaction with project team members, external customers, or vendors

  • Advantageous experience:

    • Design and generation of recombinant protein expression constructs

    • Bacterial, insect, and/or mammalian recombinant protein expression

    • Protein purification through multiple techniques (affinity, ion exchange, size exclusion)

    • Biophysical and functional characterization of recombinant proteins

    • Structure solution (eg via molecular replacement), building, and refinement of crystallographic protein structures

    • Cryo-EM protein sample / grid preparation

The successful candidate will be a results-focused, team-oriented bench scientist able to excel across multiple projects in a dynamic fast-paced environment. S/he must be accountable, self-motivated, detail-oriented and exhibit problem solving skills. In addition, the successful candidate will be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with team members.


[Post Date: November 19, 2021]


Institute Research Investigator Structural Biology

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Description:

Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new targeted, immune- and cell-based therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery, with a multidisciplinary team of dedicated researchers, doctors, drug developers and scientific experts working together to develop small-molecule drugs, biologics and cellular therapies. Our unique structure and collaborative approach allow the team to work with agility, bringing novel medicines from concept to clinic quickly and efficiently - all under the same roof.

The Therapeutics Discovery Division is built around four platforms: The Institute for Applied Cancer Science (IACS), ORBIT (Oncology Research for Biologics and Immunotherapy Translation), TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology) and the Neurodegeneration Consortium.

The IACS platform is focused on discovering and developing the next generation of small-molecule targeted therapies, driven by the needs we see in our patients. The team aligns world-class drug discovery and development research with the science and clinical care for which MD Anderson is known. We work in a fast-paced, milestone-driven environment with a focus on team science and interdisciplinary research. Our unique approach has created a biotech-like engine within the walls of the nation's leading cancer center to bring life-saving medicines to our patients more quickly and effectively. This model already has achieved results, with multiple programs currently in clinical and late-stage preclinical development.

The Institute Research Investigator in the structural chemistry group of the Institute for Applied Cancer Science (IACS) participates in cross-functional research to advance our drug discovery projects from early exploratory efforts through lead optimization, ultimately delivering therapeutic agents of benefit to patients. As part of the IACS team, the Institute Research Investigator will be responsible for solving single-particle cryo-EM structures of target proteins and complexes, supporting the design of novel therapeutics by elucidating small molecule binding modes, and identifying opportunities for allosteric or molecular glue-based protein modulation.

By joining the Therapeutics Discovery Division, you have the opportunity to use your talents to make a direct impact on the lives of our patients. We are seeking a highly motivated and collaborative individual to become a part of our team. The ideal candidate will have a demonstrated track record of solving challenging protein structures using single-particle cryo-electron microscopy and X-ray crystallography.

Key Functions

  1. Apply and develop cutting edge single-particle cryo-EM tools and methodologies to enable advancement of Institute projects through leadership and experimental activities. Analyze structural data generated by various studies and leverage results for the design of future studies.
  2. Work in close collaboration with cross-functional drug discovery project teams by leveraging the latest structural biology and structural bioinformatics approaches.
  3. Generate high-resolution structures of key small molecule compounds bound to their protein targets using cryo-EM and/or X-ray crystallography.
  4. Solve structures of target proteins within biologically relevant complexes to identify opportunities for allosteric inhibition and/or modulation by molecular glues.
  5. Collaborate with medicinal and computational chemists in the design of compounds with improved affinity, selectivity, and properties using protein structural information.
  6. Design novel protein constructs to enable pull-down of biologically relevant complexes and improve protein expression, purification, crystallization, and aggregation.
  7. Optimize cryo-EM grid conditions to improve data quality and consistency.
  8. Carry out biophysical experiments to evaluate protein-ligand binding affinity and prioritize ligands for structural work.
  9. Communicate structural biology results to a broad scientific audience from diverse disciplines.
  10. Employ safe lab practices.
  11. Maintain research records and laboratory notes.

EDUCATION:
Required: Bachelor's degree in biology, biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.

Preferred: PhD in one of the natural sciences or related field or Medical degree.

EXPERIENCE:

Required: Six years experience of relevant research experience in laboratory. With a Master's degree, four years of required experience. With a PhD in a natural science or Medical degree, no experience required.

Preferred: Extensive knowledge of contemporary single-particle cryo-EM, and familiarity with X-ray crystallography, nuclear magnetic resonance, and/or structural bioinformatics, as evidenced by a strong publication record in peer reviewed journals. Extensive experience with cryo-EM sample preparation (eg. vitrobot, Leica) and data collection on modern microscopes (eg. Glacios, Krios, Tundra). Expert knowledge of the latest single-particle cryo-EM data processing software (eg. CryoSPARC, RELION, etc.) and familiarity with crystallographic refinement software. Experience using biophysical methods (eg. ITC, SPR, DSF, MST) to evaluate protein-ligand binding affinity, binding kinetics, complex formation, etc. Experience solving structures of membrane proteins. Excellent communication, writing, and organizational skills. Experience working with medicinal and computational chemists.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

Additional Information

  • Requisition ID: 145042
  • Employment Status: Full-Time
  • Employee Status: Regular
  • FLSA: exempt and not eligible for overtime pay
  • Work Week: Days
  • Fund Type: Soft
  • Pivotal Position: Yes
  • Minimum Salary: US Dollar (USD) 85,000
  • Midpoint Salary: US Dollar (USD) 106,250
  • Maximum Salary : US Dollar (USD) 127,500
  • Science Jobs: Yes


[Post Date: November 18, 2021]


Postdoc University of Manitoba

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Description:

A postdoc position is available in the Stetefeld lab at the University of Manitoba in the area of “Structural biology of protein-protein network formation”. Our lab studies cell surface receptors and their interactions with various ligand molecules.

Minimum requirements for applicants include a PhD in Biochemistry a/o Biophysics, extensive experience in either X-ray crystallography or cryo-EM, as well as protein expression, purification and characterisation. The candidates are expected to apply an integrated structural biology and biophysics approach.

Our lab has steady access to in-house X-ray and cryo-EM facilities and hosts state of the art biophysics infrastructure (CISB). We are a partner lab of NANOTEMPER and perform several AI-driven structure-based drug design projects with ATOMWISE.

More information about the Stetefeld lab can be found at our website: https://stetefeldlab.ca/

If you are interested, please contact me by email at jorg.stetefeld”at”umanitoba.ca, with a CV, a one-page statement of research interests, and 3 names of referees.


[Post Date: November 18, 2021]


Postdoc Structural Biology Curie Institute Paris, France

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Description:

We are looking for a post-doctoral fellow to join the team Structural Motility at the Curie Institute (Paris Center) directed by Anne Houdusse.

The Structural Motility team at the Institut Curie has gathered important structural insights on how force generated by molecular motors can power cellular processes in human health and disease. We combine chemical biology and cell biology approaches to test these insights and understand how molecular motors produce force, how their activity is regulated and how they are recruited to their cellular targets. Many of these motors are also involved in human pathologies and they are thus good targets for new therapies which we are helping to develop.

We are looking for an expert in biochemical, crystallogenesis and structural determination studies (X-ray and/or CryoEM). The post-doctoral fellow will also gain expertise in functional and cellular studies.

A solid experience in structural determination is required. Experience in the production and purification of recombinant proteins is a plus but we are ready to train a dynamic and motivated candidate.

If you are interested, please send a CV and a letter of motivation as well as letters of recommendation of your previous employers.

Contact : Anne Houdusse (anne.houdusse@curie.fr)

https://science.institut-curie.org/research/multiscale-physics-biology-chemistry/umr144-subcellular-structure-and-cellular-dynamics/team-houdusse/

Recent publications

Gyimesi M, Horváth ÁI, Túrós D, Suthar SK, Pénzes M, Kurdi C, Canon L, Kikuti C, Ruppel KM, Trivedi DV, Spudich JA, Lőrincz I, Rauscher AÁ, Kovács M, Pál E, Komoly S, Houdusse A, Málnási-Csizmadia A. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell : 335-346 : DOI: 10.1016/j.cell.2020.08.050

Julien Robert-Paganin, Olena Pylypenko, Carlos Kikuti, H Lee Sweeney, Anne Houdusse Force Generation by Myosin Motors: A Structural Perspective. Chemical reviews : 5-35 : DOI : 10.1021/acs.chemrev.9b00264Robert-Paganin et al, Nat Commun. 10, 3286, 2019.

Robert-Paganin et al, Nat Commun. 9, 4019, 2018.

Planelles-Herrero VJ, Hartman JJ, Robert-Paganin J, Malik FI, Houdusse A. Mechanistic and Structural Basis for Activation of Cardiac Myosin Force Production by Omecamtiv Mecarbil. Nat. Commun. 8, 190, 2017.

Yu I-M*, Planelles-Herrero VJ*, Sourigues Y, Moussaoui D, Sirkia H, Kikuti C, Stroebel D, Titus MA, Houdusse A. Myosin 7 and its Adaptors Link Cadherins to Actin. Nat Commun. 8, 15864, 2017.

Houdusse A, Sweeney HL. How myosin generates force on actin filaments. Trends Biochem Sci. 41, 989-97, 2016.

Sweeney HL and Houdusse A, Myosin VI rewrites the rules for myosin motors, Cell, 141, 573-82, 2010.

Sweeney HL and Houdusse A. Structural and Functional Insights into the Myosin Motor Mechanism, Annu Rev Biophys. 39, 539-57, 2010.

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[Post Date: November 18, 2021]


Research Associate Structural Biology

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Description:

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Research Associate Structural Biology located in our San Diego, California office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

OBJECTIVES/PURPOSE

●  The successful candidate will perform routine assignments and protocols that are critical to the functioning and productivity of the Structural Biology group 

●  The successful candidate will manage the macromolecular crystallization facility and perform routine experiments

●  The successful candidate will contribute to the design and implementation of improvements for routine procedures

ACCOUNTABILITIES

  • General maintenance of the equipment and supplies of the macromolecular crystallization lab
  • Under general supervision, performs a wide range of assigned research experiments with
    efficiency, accuracy and attention to detail, such as robotic and manual crystallization experiments, tracking crystal growth, crystal handling and harvesting
  • Performs calculations and basic analysis on experimental results and develops hypothesis
  • Assist with synchrotron beamtime applications, paperwork, and logistics
  • Coordinate with CRO on synchrotron data collection, data retrieval, and storage
  • Maintains good laboratory and office records
  • Support other functional areas within the Structural Biology group when needed

DIMENSIONS AND ASPECTS

Technical/Functional (Line) Expertise

  • Demonstrates technical knowledge of the field of biology/chemistry, and a strong interest in the field of drug discovery and development
  • Demonstrates motivation and agility to learn new knowledge, techniques, software, and take on new tasks
  • Capability to perform routine lab work independently with minimum to no supervision upon full training
  • Highly skilled in Microsoft Office applications especially Excel
  • Experience with computer programming language and with Linux operating system is desirable

Interaction

  • Frequent email and telephone communications with external parties are required

Innovation

  • Receives general instructions on routine work; detailed instructions on new assignments

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

  • BS degree in a related scientific discipline
  • Relevant experiences in a research laboratory

ADDITIONAL INFORMATION

  • Must be legally authorized to work in the US

WHAT TAKEDA CAN OFFER YOU:

  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs


[Post Date: November 18, 2021]


NIH Funded Post-Doc Position for X-ray crystallography - Flaherty Lab - Purdue University

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Description:

The laboratory of Dr. Daniel Flaherty in the Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University is seeking a post-doctoral research associate in the field of protein X-ray crystallography to support drug discovery efforts against a novel antibacterial target of interest in our laboratory. Required degree/skills: PhD (or expected PhD) with experience in protein crystallography and biophysical techniques with a proven track record of successfully solving ligand-bound crystal structures. Required experience includes designing plasmids, cloning, mutagenesis, protein preparation, protein purification, and a strong background in utilizing PHENIX and COOT or other comparable software for structure determination. Desired Skills: Experience designing and executing biochemical assays for quantifying protein interactions with small molecules, such as with surface plasmon resonance (SPR) or isothermal titration calorimetry (ITC). Experience working with bacteria including E. faecium, E. faecalis, N. gonorrhoeae and M. smegmatis is a plus.

The candidate would have access to world-class facilities and instrumentation to support their work (crystallization drop-setting robots, screen optimization robots, plate imaging robots/hotel, walk-in plate incubator rooms, and rotating-anode home X-ray sources) within the Crystallography Core located in the Hockmeyer Hall of Structural Biology. Synchrotron data collection is also a 2-hour drive from our laboratory at the Advanced Photon Source (APS) at Argonne National Laboratory with remote data collection capabilities. Other responsibilities include managing data collection time/trips, maintaining a laboratory notebook, assisting graduate students in crystallography, and manuscript preparation. This position is funded by a grant from the National Institutes of Health in search of novel inhibitors for a new antibacterial target. The position offers a competitive salary commensurate upon experience plus benefits and is contingent upon meeting progress milestones. The successful applicant will be assessed for productivity on a bi-annual basis with the option of yearly renewal if agreed upon by both parties. 

Interested candidates should submit a cover letter, CV and at least 3 references that are familiar with the candidate’s experience and research potential to https://careers.purdue.edu/job/West-Layayette-Post-Doc-Research-Associate-IN-47906/814628700/?locale=en_US . The position is open immediately, however, start date is flexible and negotiable depending on the availability of the candidate. For more information please visit https://www.flahertylab.com/positions


[Post Date: November 17, 2021]


Research Associate

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Description:

We have a postdoctoral position available to study host-virus interactions and coevolution in the group of Prof. Yorgo Modis in the University of Cambridge Department of Medicine. The Modis group is part of the Molecular Immunity Unit within the MRC Laboratory of Molecular Biology (MRC-LMB). We benefit from the outstanding scientific environment and infrastructure of the MRC-LMB, and from being part of the virology and immunology community as members of the Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID).

The group's key research questions are: How do cells recognize viral RNA with the necessary sensitivity and specificity? How do cells repress expression of integrated viral genes? And what are the functions of endogenous viral genes that escape repression? We aim to understand these processes at the molecular level by integrating mechanistic insights from structural studies with functional validation in the cellular context. Our projects have important potential applications in global health.

We seek a highly motivated research scientist with a PhD in the biological, biochemical or biomedical sciences, and relevant research experience in protein biochemistry and macromolecular structure determination. Candidates must have one or more first-author research article(s) published in a peer-reviewed journal or under review with a preprint available. Experience in eukaryotic expression systems, cell-based assays, immunofluorescence microscopy and bioinformatics is desirable.

Candidates in the process of submitting their PhD thesis or awaiting degree conferral will be considered. In this case, appointment would be at the level of Research Assistant, Grade 5, On receipt of PhD award, the appointee would move to Grade 7, Research Associate.

The position is available for two years in the first instance and is funded by the Wellcome Trust.

Informal enquiries are welcomed and should be directed to Prof. Modis at ym10000@cam.ac.uk

Fixed-term: The funds for this post are available for 2 years in the first instance.  Closing Date: 16th January 2022


[Post Date: November 17, 2021]


Postdoctoral researcher in structural biology of transcription factor NF-kappaB

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Description:

The laboratory of Dr. Vivien Wang is currently recruiting a Postdoctoral Fellow to conduct structural study on protein complexes involving in NF-kappaB and IkappaB signaling. The major responsibilities include (1) X-ray structural study of NF-kappaB, IkappaB and DNA complexes; (2) biochemical and biological studies to provide greater functional understanding of these macromolecules; and (3) crystallization of other related proteins. The postdoctoral fellow will also help maintain the lab and provide technical supports and supervisions to the graduate students.

Applicants should have a Ph.D. degree in biological sciences or related fields. Expertise in cloning, protein purification, and x-ray crystallography is a must. Experience with cell culture, cell assays, and other molecular biology techniques is a plus. Applicants should also have positive work attitude, good organization, and communication skills, and are highly motivated and self-initiated, capable of independently performing in-depth research, multi-tasking along with problem-solving expertise and good team player. Previous publications related to protein crystallography, biochemistry, etc. in international peer reviewed journals are a prerequisite.

Contract Period

One year and renewable subject to mutual agreement and availability of funding.

Remuneration

Remuneration is highly competitive and commensurate with the successful applicants’ academic qualification, current position and professional experience.

Application Procedures

Applicants should send the cover letter, an up-to-date C.V. and other relevant documents to Prof. Vivien Wang (email: vivienwang@um.edu.mo). https://fhs.um.edu.mo/en/staff/vivien-ya-fan-wang/

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[Post Date: November 15, 2021]


Senior Scientist - Structural Biology

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Description:

We are seeking a Scientist to join our Boston-area structural biology group conducting drug design research in diverse therapeutic areas. Our group integrates with multidisciplinary project teams to accelerate drug discovery on innovative and challenging targets using x-ray crystallography and cryo-EM. To expand the latter, a state-of-the-art facility is under construction at our new 2022 Cambridge campus. The successful candidate will generate structure-grade protein, and use such protein for structural studies using cryo-EM or crystallography in order to drive drug-design workflows. Significant experience with single-particle cryo-EM data generation and processing is desired. The successful candidate will work closely with members of the Structural Biology, Biochemistry and Biophysics teams, as well as members of the therapeutic area groups, and must be an enthusiastic team player with excellent communication skills and must bring curiosity and a desire to make an impact in the workplace.

Basic Qualifications:

PhD in Biochemistry or a related field (Biology, Cell Biology, Biotechnology, etc.) and 3+ years of experience in protein expression, purification and cryo-EM studies, or BS degree and 8+ years of relevant experience.

Preferred Qualifications:

Extensive track record with purification and structure determination of challenging proteins, (e.g., membrane proteins, complexes, etc.) by cryo-EM or crystallography. Hands-on operation of high-end cryo-electron microscopes, extensive familiarity with EM data processing suites. Industrial experience.

If interested, please apply using this link:

https://sanofi.wd3.myworkdayjobs.com/SanofiCareers/job/Waltham-MA/Senior-Scientist---Structural-Biology_R2621212-1


[Post Date: November 12, 2021]


Postdoctoral researcher in structural biology of glycan-modifying enzymes

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Description:

The Faculty of Science, Leiden Institute of Chemistry

Key responsibilities

A postdoctoral position is available in the research team of Dr. Zach Armstrong working on the structural biology of glycan-modifying enzymes. The project is aimed at the structural biology of human and viral enzymes that modify glycocalyx sugars. This will also involve the testing of mechanism-based inhibitors for the same enzymes. This will be achieved through protein production in insect and human cells, protein purification, enzyme kinetics, application of precision chemical tools and structural biology of enzymes and their complexes (X-ray/CryoEM). The postdoctoral researcher must be flexible and communicative and have experience in both biochemistry and structural biology labs.

The key responsibilities of the project will be:

  • Expression of mammalian (and viral) genes in insect and human cell systems;
  • Enzyme kinetics, including enzyme inhibition kinetics and determination of substrate specificity;
  • Structure solution by X-ray crystallography (CryoEM where appropriate): crystallization, data collection and structure solution / refinement / deposition;
  • To keep up-to-date, in a pro-active manner, with scientific literature in the field of carbohydrate chemistry and glycobiology and help disseminate this information through to the group;
  • To provide guidance to other staff and students, as required, as well as coordinating the work of small research teams;
  • To supervise Masters and Bachelors project students in the laboratory.

Selection Criteria

  • PhD-degree in Structural Biology, Biochemistry or Chemistry and proven ability of producing scientific output;
  • Experience with Mammalian or Insect protein expression systems;
  • Experience with Structural biology, Cryo-EM or X-ray Crystallography;
  • Knowledge of enzyme kinetics is preferred;
  • Experience with membrane proteins is preferred;
  • Excellent communication skills in the English language are essential.


[Post Date: November 12, 2021]


Chemistry and Biochemistry Department Chair

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Description:

Description

The Department of Chemistry and Biochemistry at the University of Oklahoma (OU) is seeking qualified applicants for the position of Department Chair. The successful candidate should have established an excellent reputation of scholarship and a strong funding record in chemistry and/or biochemical research as well as demonstrated administrative and leadership experience relevant to serving as department chair.

Job Description

Service/Leadership

  • Provide leadership to maintain and improve an inclusive, diverse, dynamic, and collaborative environment to stimulate the faculty to conduct excellent research and teaching.
  • Oversee departmental strategic planning, including research, teaching, and service.
  • Align departmental efforts with the Strategic Plan of the College of Arts and Sciences and the University of Oklahoma.
  • Provide proactive leadership to promote teamwork and working efficiency of faculty and staff.
  • Provide leadership to create and maintain an efficient system to manage personnel, space, and budgetary matters in a transparent and timely manner.
  • Support and communicate effectively with diverse groups of students, faculty, and staff.
  • Oversee recruitment, development, and retention of faculty, staff, and students
  • Effectively communicate with all administrative levels of the University and external institutes and agencies.
  • Oversee curriculum development and modification.
  • Provide leadership to maintain and promote safety in a laboratory-based working environment.
  • Work with departmental committees to perform administrative activities:
    • Supervision and annual evaluation of faculty in terms of teaching, research, and service.
    • Supervision and annual evaluation of support staff.
    • Manage personnel matters and service assignments.

Research

  • Maintain a vigorous, extramurally funded research program to provide research opportunities for training graduate, post-doctoral, and undergraduate students.
  • Enhance research and education relationships within the Department, across the University, and with other research institutions and agencies.

Teaching

  • Participate in teaching undergraduate and graduate students in the Department of Chemistry and Biochemistry.
  • Teach one course per academic year.

OU is a public research university located in Norman, Oklahoma. OU’s enrollment of undergraduate is more than 20,000, and the population graduate students is more than 6,000. The Department of Chemistry and Biochemistry has 30 full-time faculty members and more than 100 graduate students. The research and administrative functions of the department are housed in the Stephenson Life Sciences Research Center, located on OU’s Research Campus. The completion of the 160,000-square-foot center was made possible by a generous from Charles and Peggy Stephenson. Completed in July 2010, it houses chemists, biochemists and other life sciences researchers.  The Department of Chemistry Research Support Services (RSS) employs 7 PhD scientists and technicians that are responsible for the training of students, postdocs and faculty in the use of departmental instrumentation (NMR, mass spectrometry, X-ray crystallography facilities etc.). Additionally, the RSS also provides access to electronics shop, glassblowing laboratory, and stockroom.

Qualifications

  • Candidates should hold a Ph.D. in chemistry or biochemistry, and should have an internationally recognized reputation and outstanding record of accomplishments in chemistry or biochemistry.
  • Rank of Associate Professor or higher with tenure (or equivalent rank).
  • Demonstrated success in administration of strategic planning, budgeting, and collaboration with colleagues.

Application Instructions

The application package consists of a cover letter, a statement of leadership, research plan (max 5 pages), and a current curriculum vitae that includes a list of publications. The name and contact information of three professional references should be provided. The review of applications will start by November 15, 2021 and will continue until the position is filled. There will be a preliminary remote screening process to arrive at a final list of candidates. Top candidates will be informed about the next steps (virtually vs in-person), subject to changes depending on the developments concerning the ongoing global pandemic.

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[Post Date: November 12, 2021]


Staff Scientist - Protein Purification and X-ray Crystallography

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Description:

The Williams’ lab at Beckman Research Institute at the City of Hope is  looking for a highly motivated X-ray crystallographer to join a dynamic research group (15+) driving translational science to treat patients with cancer and diabetes.   The successful candidate will join as a staff scientist and participate in projects that are highly collaborative - often bridging biophysical and synthetic efforts with basic research groups (in vivo and in vitro studies) and practicing clinicians.  Critically, City of Hope a large number of core facilities including three FDA-approved GMP facilities to support the translation of these studies to clinical trials.  In fact, there are currently has 92 active INDs at City of Hope.

Key Responsibilities:

  • Involved in multiple projects across the institute including small molecule discovery using fragment screening (diffraction, SPR and DSF based and supported by the synthetic chemistry core)
  • Will participate in the development of biologics including conditionally activated IO therapeutics.  
  • Immersed in a large group with experience that spans antibody discovery (using cutting edge technologies such as single cell mAb identification), advanced protein engineering and in vivo and in vitro screening with the urgent goal of improving patient’s lives.

Basic education, experience and skills required for consideration:

  • The Staff Scientist must possess a PhD or other doctoral level degree.
  • Having a background in Structural Biology.
  • The ideal candidate should also have deep experience running SPR, ITC, CD, AUC and DSF.  
  • Additional experience in CryoEM is desirable. 
  • Experience in cloning and purification of proteins from E coli, yeast, insect and mammalian cell lines is also necessary

The lab houses numerous instruments including Rigaku 007 with HiPix detector, Mosquito crystallization robot, Formulatrix Imaging robots, multiple FPLCs, HPLCs, a T200 SPR, Waters Nano ITC, Kinexa3000, Beckman Proteome, Sony Cell sorter, Berkeley Lights Beacon, and ample access to synchrotron time. The Beckman Research Institute and the NCI designated cancer center supports multiple cores.

We will be competitive in terms of salary and benefits

Please apply at:  https://aa067.referrals.selectminds.com/jobs/staff-scientist-protein-purification-and-x-ray-crystallography-8567


[Post Date: November 10, 2021]


Research Scientist

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Description:

Looking for your first job in the pharmaceutical industry? Can you commit for a year? Do you enjoy protein purification, and can you operate an AKTA to run IMAC, IEX and SEC protein purifications without supervision? Do you want an opportunity to learn about antibody and small molecule drug discovery, by attending the project meetings? Then maybe one of these maternity cover positions in our Protein Purification team at UCB (Slough, UK) will interest you:

  • Maternity cover 1: January 1st 2022 – December 31st 2022
  • Maternity cover 2: February 1st 2022 – January 31st 2023

A full job description can be found below. If you want to apply, send your CV and cover letter to: protein.purification@ucb.com

Research Scientist – maternity cover – UCB (Slough, UK)

Everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” And to find the answers, we connect globally with patients and their families living with the physical and social burdens of severe disease. These connections give us new perspectives, drive our innovation, and offer a hope for a new generation of therapies that will help to transform lives.

Role overview

The Protein Production Group provides support for all NBE & NCE projects from early stage target validation through to those undergoing pre-clinical evaluation, by generating recombinant protein reagents for immunization, structural studies, assays and compound screening.  All reagents produced undergo biophysical analysis in order to enhance our understanding of their stability and solubility.  You will be part of the Protein Production Group playing a key role in project success by generating high quality protein reagents in a timely manner.

The successful candidate will have the opportunity to rapidly impact on a wide range of our NBE & NCE projects, and to significantly contribute to the progression of these projects into the clinic and beyond.

Primary responsibilities

  • You will be responsible for expressing and purifying high-quality recombinant protein reagents to support UCB’s novel world-leading antibody and NCE drug discovery platforms for a variety of exciting therapeutic projects.
  • You will use your excellent practical skills, communication and team working abilities to drive innovative projects forward from the laboratory.
  • You will be responsible for clearly presenting work and engaging in discussion in a variety of cross-functional and external collaborator meetings.

Essential experience

Candidates may be fresh PhD holders with relevant experience, or Bachelor/MSc degree holders currently working as skilled Research Scientists, within the Biopharmaceutical or Pharmaceutical industry.

We are looking for candidates who are fully independent and competent in the following skill sets:

  • Molecular Biology (DNA manipulation techniques and use of VNTI and/or other DNA analysis software).
  • Protein Expression in coli and/or Mammalian cell systems.
  • Protein Purification (Affinity, Ion Exchange, Size Exclusion Chromatography, UV-Vis spectroscopy, protein refolding techniques and extensive working knowledge of AKTA purification platforms and associated software)
  • Protein Analysis (SDS PAGE, UPLC/HPLC, Western blotting)
  • Molecular Visualisation of proteins (PyMOL or similar).
  • Experience with X-ray crystallography or cryo-EM would be an advantage
  • Ability to work on several projects and conduct experiments in parallel.
  • Proficiency in the use of Microsoft Office.
  • A highly motivated individual with a proven ability to deliver to tight timelines.
  • A team player, with good organisational, communication, record keeping and inter-personal skills are essential requirements. 
  • Presentations within the group and to project teams will also be expected. 
  • Possess an inquisitive and innovative nature and a passion for delivering innovative new medicines for patients suffering with serious disease.

We can offer you the opportunity to rapidly impact on a wide range of our NBE & NCE projects, and to significantly contribute to the progression of these projects into the clinic and beyond.  Informal and open working environment that does not lock scientists into structure and hierarchy.  Freedom to take space to pursue your own ideas and make a difference.  Opportunities and expectations to develop global visibility and an international reputation as a scientist in your field.


[Post Date: November 10, 2021]


Postdoc Cryo-EM and Crystallography of Ion Channels in Vancouver, Canada

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Description:

A postdoc position is available immediately at the University of British Columbia.

The project combines X-ray crystallography, cryo-EM, and electrophysiology. Our lab has steady access to the in-house X-ray and cryo-EM facilities: 

  • Microscopes: 300kV Titan Krios with Falcon IV detector and Selectris Energy filter.   A 200kV Glacios (Falcon III detector) is available for prescreening grids
  • X-ray equipment in the lab includes Mosquito and Dragonfly robotics, and we have regular access to an in-house X-ray diffractor (Rigaku Micromax-007 HF with Saturn 744+ CCD detector) and various synchrotron beamlines

Minimum requirements for applicants include a PhD in Biochemistry or a related discipline with extensive experience in either X-ray crystallography or cryo-EM, as well as protein expression and purification.  Direct experience with membrane proteins is an additional plus.

The lab values diversity and inclusivity, and applicants from all backgrounds are encouraged to apply. This is an opportunity for people with structural biology expertise to learn electrophysiological methods.

Recent work from the lab includes an investigation of how Ryanodine Receptors are modulated by small molecules, disease mutations, and post-translational modification, using cryo-EM, X-ray crystallography, planar lipid bilayer electrophysiology, and enzyme kinetics.

Woll et al (2021) Nature Comm. 12:807

Ma et al (2020) Nat Chem Biol. 16,1246-1254

Haji-Ghassemi et al (2019) Molecular Cell 75,1-14 

For more information on recent work, see http://crg.ubc.ca/VanPetegem/

The lab is housed within the Life Sciences Centre at UBC (lsi.ubc.ca), located on the Point Grey campus in Vancouver.

Interested candidates should send a CV, along with names and contact details for 3 references to filip.vanpetegem@gmail.com.


[Post Date: November 10, 2021]


Biophysics Scientist - SPR opportunity at Sosei Heptares, UK

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Description:

We are seeking a motivated and passionate scientist specialising in biophysical analysis of proteins, to join the Biophysics group at our research facility in Granta Park, Cambridgeshire, UK. This is an excellent opportunity for a biophysical scientist to play a role in drug discovery projects at Sosei Heptares. We apply biophysics in small-molecule drug discovery from hit ID to clinical candidate.

The successful candidate is expected to:

  • Provide quantitative biophysical data on protein-ligand binding (compounds and other drug modalities) including affinity, kinetic and stoichiometric

        data to inform chemistry design and mechanistic understanding.

  • Perform fragment and other compound screens, validate, and characterise hits from these screens to inform design.
  • Generate high fidelity and reproducible data and insights on the molecular mechanism of lead compounds and drug candidates.
  • Purify and prepare samples for biophysical analyses as required.
  • Identify and drive improvements and innovations in biophysics, expanding the scope of biophysical methods currently employed at Sosei Heptares.
  • Collaborate with other Sosei Heptares scientists on research projects successfully progressing membrane protein targets through Sosei Heptares’ structure-based drug design pipeline.
  • Prepare and effectively present results (written and oral) to project teams.

Requirements

  • Have received/about to receive a PhD in biochemistry/biophysics or a related discipline or have equivalent relevant experience in a drug discovery setting.
  • Expertise in biophysical characterisation of molecular interactions and mechanistic insights using Surface Plasmon Resonance (SPR).
  • Experience in other biochemical and biophysical methods such as nDSF, fluorescence-based approaches, mass spectrometry or single-molecule methods.
  • Prior experience working with membrane proteins would be considered an advantage.
  • Have strong interpersonal skills and interact effectively with collaborators across a wide range of disciplines.

Other Information

The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation. 

We offer a competitive salary and benefits package commensurate with qualifications and experience.

Candidate must have the right to work in the United Kingdom.

Heptares is an equal opportunities employer.

Applications should include a CV and covering letter, providing a short description of the background and interest in the role. Please apply through our on-line jobs’ portal at: https://bit.ly/30605vn ; with your application in pdf format, quoting reference number 2021-5BPhy-SPR. The closing date for applications is 31st December 2021.

Sosei Heptares does not accept speculative or unsolicited CVs from agencies. All speculative or unsolicited CVs submitted without an agreement in place will be considered Sosei Heptares' property and will not obligate us to pay a referral fee.


[Post Date: November 9, 2021]


Structural Biologist

View the Job Posting Here

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Description:

Syngenta is looking for a motivated and independent structural biologist with Masters or PhD level qualifications ideally having worked with different protein targets being soluble and/or membrane-bound. This position is a great opportunity for scientists interested in an industrial career to gain practical industry experience, working on structural biology platform activities which would mostly be structure solution with the potential for construct design, protein expression, purification and biophysics too depending on the project. Prior experience in structure solution by crystallography or cryo-EM is essential, whilst the rest of the pipeline described above would be preferred.

 

The successful candidate will work alongside other structural biologists as well as part of multidisciplinary project teams, with their contributions supporting chemistry design throughout R&D. Excellent oral and written communication skills and the ability to work in multidisciplinary project teams are highly desirable qualities for this position.

If you would like to find out more then please get in touch (jenny.moore@syngenta.com) or apply directly here - https://www.srgtalent.com/jobs/j2162167-structural-biologist


[Post Date: November 9, 2021]


Postdoc Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine

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Description:

A postdoctoral position is available immediately at the Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine to study the molecular mechanisms of vertebrate visual transduction. We are using multiple approaches, including protein structure-function analysis, biochemistry, structural and molecular biology. A successful applicant will have a PhD, experience in biochemistry/structural and molecular biology, and a relevant publication record. Experience in x-ray crystallography and/or cryo-EM is preferred. Salary is commensurate with experience.

The University of Iowa is located in Iowa City, a dynamic college-town within driving distance of Chicago, St. Louis, and Minneapolis. Iowa City offers a culturally rich and highly academic environment supportive of the arts and sciences. The University of Iowa is part of the Molecular Biology Consortium that gives us substantial beam time for crystallographic studies at the 4.2.2 ALS beamline (Lawrence Berkeley National Labs). We have active proposals at the Pacific Northwest Cryo-EM Center (PNCC) in Portland, OR.

Interested applicants should send a summary of previous research and a CV with names of at least two referees by e-mail to nikolai-artemyev@uiowa.edu


[Post Date: November 2, 2021]


XFEL Crystallography Specialist

View the Job Posting Here

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Description:

Lawrence Berkeley National Lab’s (LBNL) Molecular Biophysics & Integrated Bioimaging Division has an opening for a XFEL Crystallography Specialist to join the team.

In this exciting role, you will work as part of a group focusing on scientific software for X-ray crystallography.  The next decade of structural biology at X-ray free-electron lasers (XFELs) will include groundbreaking advances in time-domain crystallography, performed at room temperature to preserve biologically relevant dynamic mechanisms.  Considering the anticipated scale of these data, we have ambitious collaborations with experimental groups targeting structural biology, light source science groups at facilities such as the Linac Coherent Light Source (LCLS), and high-performance computing groups at national supercomputing facilities such as the National Energy Research Scientific Computing Center (NERSC), also located in Berkeley.   

The group’s projects will include 1) Photosystem II, discovering the sequence of redox events leading to the release of molecular oxygen, using a combination of time-resolved crystallography and X-ray emission spectroscopy; 2) Examining the electronic environment of metalloenzyme catalytic metals, with detection based on anomalous scattering; 3) evaluation of XFEL methods for small-molecule structure determination.  You will be positioned to launch into High Performance Computing (HPC) careers at light source or other experimental facilities.

What You Will Do:

  • Participate as the crystallography specialist on multidisciplinary teams performing XFEL experiments.
  • Take the lead on developing and testing software for X-ray free-electron laser (XFEL) crystallography, using our previously developed packages (cctbx.xfel and dials) as a starting point.
  • Develop a deep understanding of the hardware available for Exascale computing (including Perlmutter, Aurora and Frontier), along with GPU accelerators.
  • Work at the interface between supercomputer design teams, computer science groups, LCLS beamline scientists, and X-ray crystallography user groups.  
  • Derive new algorithms to adapt to heterogeneous experimental designs.
  • Deliver new features on time and in support of structural biology.
  • Deliver U.S. Department of Energy (DOE)-mandated software development milestones on time, including tested code checked in to repositories, accompanied by written reports.  
  • Write one first-author paper per year in scientific publications.
  • Present work at conferences, and continuously communicate results to several collaborating groups.

Additional Responsibilities as needed:

  • Support scheduled beam time data collections at remote global facilities.

What is Required:

  • At least 3 years of professional experience beyond the highest customary degree in Biophysics, Bioinformatics, Mathematics, Computer Science, Engineering, Physical Sciences, or related field.
  • Working knowledge of crystallographic data collection, processing, molecular modeling, and model validation.
  • A publication record reflective of this experience.
  • Expertise with modern object-oriented, version-controlled software development, with a team-oriented approach.
  • Proficiency with Linux, Python, and C++.
  • Excellent oral and written communication skills.
  • Demonstrated ability to analyze complex problems with broad supervision, and develop strategies to solve specific problems while running appropriate controls to validate the correct results.
  • Proven ability to work effectively in an R&D environment as part of a cross-disciplinary team.
  •  

Desired Qualifications:

  • Ph.D. in Biophysics, Bioinformatics, Mathematics, Computer Science, Engineering, Physical Sciences, or related field.
  • Proven excellence in signal processing, image processing, and multivariate statistics.
  • Experience with GPU computing.
  • Experience in a high-performance computing environment.
  • Machine learning, for example TensorFlow or PyTorch experience.

Notes:

  • This is a full time 2 year term appointment with the possibility of extension or conversion to Career appointment based upon satisfactory job performance, continuing availability of funds and ongoing operational needs.
  • This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
  • Work will be primarily performed at Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA.

Based on University of California Policy - SARS-CoV-2 (COVID-19) Vaccination Program and U.S Federal Government requirements, Berkeley Lab requires that all members of our community obtain the COVID-19 vaccine as soon as they are eligible. As a condition of employment at Berkeley Lab, all Covered Individuals must Participate in the COVID-19 Vaccination Program by providing proof of Full Vaccination or submitting a request for Exception or Deferral. Visit covid.lbl.gov for more information.

Berkeley Lab is committed to Inclusion, Diversity, Equity and Accountability (IDEA) and strives to continue building community with these shared values and commitments. Berkeley Lab is an Equal Opportunity and Affirmative Action Employer. We heartily welcome applications from women, minorities, veterans, and all who would contribute to the Lab's mission of leading scientific discovery, inclusion, and professionalism. In support of our diverse global community, all qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status.


[Post Date: November 2, 2021]


XFEL Crystallography Specialist Opportunity at Berkeley Lab

View the Job Posting Here

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Description:

Lawrence Berkeley National Lab’s (LBNL) Molecular Biophysics & Integrated Bioimaging Division has an opening for a XFEL Crystallography Postdoctoral Fellow to join the team.

In this exciting role you will work as part of a group focusing on software development and X-ray crystallography.  The next decade of structural biology at the Linac Coherent Light Source (LCLS) will include groundbreaking advances in time domain crystallography, diffuse scattering to observe dynamic motion, and single particle diffraction. Considering the anticipated petabyte scale of these datasets, we are undertaking ambitious collaborations with experimental groups targeting structural biology, light source facilities such as the Linac Coherent Lightsource (LCLS), and supercomputer centers like the National Energy Research Scientific Computing Center (NERSC), located in Berkeley.

The group’s projects will include 1) Photosystem II, discovering the sequence of redox events leading to the release of molecular oxygen, using a combination of time-resolved crystallography and X-ray emission spectroscopy; 2) Examining the electronic environment of metalloenzyme catalytic metals, with detection based on anomalous scattering; 3) Evaluation of X-ray free-electron laser (XFEL) methods for small-molecule structure determination. The postdoc will be positioned to launch into structural biology careers at light source or other experimental facilities. 

What You Will Do:

  • Participate as the crystallography specialist on multidisciplinary teams performing XFEL experiments.
  • Contribute to software development and testing for XFEL crystallography, using our previously developed packages (cctbx.xfel and dials) as a starting point.
  • Develop a deep understanding of the hardware available for Exascale computing (including Perlmutter, Aurora and Frontier), along with GPU accelerators.
  • Work at the interface between supercomputer design teams, computer science groups, LCLS beamline scientists, and X-ray crystallography user groups.  
  • Derive new algorithms to adapt to heterogeneous experimental designs.
  • Deliver new features on time and in support of structural biology.
  • Deliver U.S. Department of Energy (DOE)-mandated software development milestones on time, including tested code checked in to repositories, accompanied by written reports.  
  • Write one first-author paper per year in scientific publications.
  • Present work at conferences, and continuously communicate results to several collaborating groups.

Additional Responsibilities as needed:

  • Support scheduled beam time data collection at remote global facilities (either in-person or online).

What is Required:

  • PhD in Biophysics, Bioinformatics, Mathematics, Computer Science, Engineering, Chemical Engineering or Physical Sciences.
  • Working knowledge of crystallographic data collection, processing, molecular modeling, and model validation.
  • A publication record reflective of this experience.
  • Expertise with modern object-oriented, version-controlled software development, with a team-oriented approach.
  • Proficiency with Linux, Python, and C++.
  • Excellent oral and written communication skills.
  • Ability to work effectively in an R&D environment as part of a cross-disciplinary team.

Desired Qualifications:

  • Experience with GPU computing.
  • Experience in a high-performance computing environment.
  • Machine learning, for example TensorFlow or PyTorch experience.

Notes:

  • This is a full-time 2 year postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 3 years of paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree.
  • This position is represented by a union for collective bargaining purposes.
  • Salary will be predetermined based on postdoctoral step rates.
  • This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
  • Work will be primarily performed at Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA.

Based on University of California Policy - SARS-CoV-2 (COVID-19) Vaccination Program and U.S Federal Government requirements, Berkeley Lab requires that all members of our community obtain the COVID-19 vaccine as soon as they are eligible. As a condition of employment at Berkeley Lab, all Covered Individuals must Participate in the COVID-19 Vaccination Program by providing proof of Full Vaccination or submitting a request for Exception or Deferral. Visit covid.lbl.gov for more information.

Berkeley Lab is committed to Inclusion, Diversity, Equity and Accountability (IDEA) and strives to continue building community with these shared values and commitments. Berkeley Lab is an Equal Opportunity and Affirmative Action Employer. We heartily welcome applications from women, minorities, veterans, and all who would contribute to the Lab's mission of leading scientific discovery, inclusion, and professionalism. In support of our diverse global community, all qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status.


[Post Date: November 2, 2021]


Senior Scientist- Structural Biology

View the Job Posting Here

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Description:

Evotec is a multi-modality company with operational sites in Europe and the US. We design and apply innovative technologies and processes across all modalities in order to expand access to more precise and effective medicines together with our partners. The Company has built substantial drug discovery expertise and an industrialized platform that can drive new innovative compounds into the clinic. In addition, Evotec has built a deep internal knowledge base in the treatment of diseases related to neuroscience, diabetes and complications of diabetes, pain and inflammation, oncology, infectious diseases, respiratory diseases and fibrosis. Leveraging these skills and expertise the Company intends to develop best-in-class differentiated therapeutics and deliver superior science-driven discovery alliances with pharmaceutical and biotechnology companies.

We are looking for a full-time permanent Senior Scientist for our Structural Biology team in Princeton, New Jersey.

Required knowledge, skills and abilities:

·         Extensive knowledge in macromolecular crystallography and protein biochemistry

·         Experience with construct design and protein purification

·         Familiar with biophysical techniques (in particular, Thermal Shift, SPR)

·         The successful candidate will have experience working in multi-disciplinary teams

·         Experience collaborating with scientists in external organizations.

·         Strong communication skills, both written and verbal

Responsibilities includes:

·         Reading scientific literature relevant to the project

·         Supporting project teams by designing and ordering constructs at project initiation

·         Ensuring the delivery of structural data in a timely manner

·         Preparing reports, presenting data, and collaborating with other scientists at Evotec

·         Complying fully with the company safety policy when performing experiments

·         Adhering to Lab Notebook guidelines regarding accurate documentation of lab experiments.

Desirable Knowledge, Skills and Abilities:

·         Experience with Membrane and/or Secreted Proteins

·         The ability to adapt to changing demands whilst operating under pressure

·         Previous experience with Cryo-EM

·         Self-motivated, enthusiastic, cooperative and reliable

·         Good organizational and time management skills

·         Computer proficiency

Education & Experience:

·         PhD degree in Structural Biology, Biochemistry or related area

Evotec is an Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, gender, age, disability, genetic information, gender expression, gender identity, national origin, religion, sexual orientation, or veteran status.


[Post Date: November 2, 2021]


Membrane Protein Crystallographer

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Description:

Main Scope of Role:

Evotec (UK) Limited is a drug discovery solutions company providing drug discovery expertise and capabilities to pharmaceutical and biotechnology companies as well as to academic institutions. The company is a wholly owned subsidiary of Evotec SE. Evotec SE is listed on the Frankfurt Stock Exchange.

The Structural Biology Department is currently seeking to recruit a motivated membrane protein crystallographer for the Abingdon site.

Key Responsibilities or Core Accountabilities:

  • Reading scientific literature relevant to the project
  • Supporting a project team by designing and ordering constructs to initiate the project
  • Adapting scientific knowledge to resolve problems encountered in achieving defined goals with assistance from line manager or other team members to meet internal and project deadlines
  • Preparing reports, presenting data, and collaborating with other scientists at Evotec
  • Presenting own work at project technical meetings, and department technical meetings when required
  • Demonstrating full command of all techniques and tools required for assigned responsibilities within the given project
  • Ensuring safe working practices of themselves and any direct reports
  • Complying fully with the company safety policy (including COPs and SOPs) when performing experiments
  • Adhering to Lab Notebook guidelines regarding accurate documentation of lab experiments

Knowledge, Skills & Capabilities:

  • Extensive knowledge in membrane protein biochemistry and macromolecular crystallography
  • Experience in lipidic cubic phase (LCP) crystallization and diffraction analysis
  • Experience with membrane protein purification
  • Protein engineering, bioinformatics and molecular biology (Construct design and cloning strategy)
  • Familiar with Biophysical techniques (DSF, ITC…)
  • A working knowledge and practical experience with either E. coli, insect or mammalian expression systems
  • The ability to adapt to changing demands whilst operating under pressure to deadlines
  • The ability to work accurately and with attention to detail
  • Good interpersonal skills and the ability to work well with other scientific staff
  • The ability to work well independently, and as part of a team
  • Good organisational and time management skills
  • Good verbal communication skills
  • Ability to maintain excellent laboratory records
  • Computer proficiency

Education, Qualifications and Experience:

  • PhD degree in Structural Biology, Biochemistry or related area


[Post Date: November 2, 2021]


RNA Crystallography Senior Scientist

View the Job Posting Here

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Description:

Main Scope of Role:

  • Extensive knowledge in RNA biochemistry and macromolecular RNA crystallography (both RNA and RNA:Protein)
  • Experience with RNA handling
  • Familiar with RNA and protein design strategies
  • Familiar with Biophysics techniques (DSF, ITC…)
  • The successful candidate will have experience working in multi-disciplinary teams
  • Experience collaborating with scientists in external organisations

Key Responsibilities or Core Accountabilities:

  • Reading scientific literature relevant to the project
  • Supporting a project team by designing and ordering constructs to initiate the project
  • Adapting scientific knowledge to resolve problems encountered in achieving defined goals with assistance from line manager or other team members to meet internal and project deadlines
  • Preparing reports, presenting data, and collaborating with other scientists at Evotec
  • Presenting own work at project technical meetings, and department technical meetings when required
  • Demonstrating full command of all techniques and tools required for assigned responsibilities within the given project
  • Ensuring safe working practices of themselves and any direct reports
  • Complying fully with the company safety policy (including COPs and SOPs) when performing experiments
  • Adhering to Lab Notebook guidelines regarding accurate documentation of lab experiments

Knowledge, Skills & Capabilities:

  • Self-motivated, enthusiastic, cooperative and reliable
  • Knowledge of basic laboratory techniques, and understanding of the science underlying the techniques and experiments
  • Experience of working in a lab environment
  • The ability to adapt to changing demands whilst operating under pressure to deadlines
  • The ability to work accurately and with attention to detail
  • Good interpersonal skills and the ability to work well with other scientific staff
  • The ability to work well independently, and as part of a team
  • Good organisational and time management skills
  • Good verbal communication skills
  • Ability to maintain excellent laboratory records
  • Computer proficiency

Education, Qualifications and Experience:

  • PhD degree or equivalent in Structural Biology, Biochemistry or related area


[Post Date: November 2, 2021]


Crystallography Senior Scientist

View the Job Posting Here

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Description:

Required knowledge, skills and abilities:

  • Extensive knowledge in protein biochemistry and macromolecular crystallography
  • Experience with protein purification
  • Protein engineering, bioinformatics and molecular biology (Construct design and cloning strategy)
  • Familiar with Biophysic techniques (DSF, ITC…)
  • A working knowledge and practical experience with either E. coli, insect or mammalian expression systems
  • The successful candidate will have experience working in multi-disciplinary teams
  • Experience collaborating with scientists in external organisations

Responsibilities includes:

  • Reading scientific literature relevant to the project
  • Supporting a project team by designing and ordering constructs to initiate the project
  • Adapting scientific knowledge to resolve problems encountered in achieving defined goals with assistance from line manager or other team members to meet internal and project deadlines
  • Preparing reports, presenting data, and collaborating with other scientists at Evotec
  • Presenting own work at project technical meetings, and department technical meetings when required
  • Demonstrating full command of all techniques and tools required for assigned responsibilities within the given project
  • Ensuring safe working practices of themselves and any direct reports
  • Complying fully with the company safety policy (including COPs and SOPs) when performing experiments
  • Adhering to Lab Notebook guidelines regarding accurate documentation of lab experiments

Desirable Knowledge, Skills and Abilities:

  • Experience in Cryo-EM
  • Self-motivated, enthusiastic, cooperative and reliable
  • Knowledge of basic laboratory techniques, and understanding of the science underlying the techniques and experiments
  • Experience of working in a lab environment
  • The ability to adapt to changing demands whilst operating under pressure to deadlines
  • The ability to work accurately and with attention to detail
  • Good interpersonal skills and the ability to work well with other scientific staff
  • The ability to work well independently, and as part of a team
  • Good organisational and time management skills
  • Good verbal communication skills
  • Ability to maintain excellent laboratory records
  • Computer proficiency

Education & Experience:

  • PhD degree in Structural Biology, Biochemistry or related area


[Post Date: November 2, 2021]


Experienced Scientist with a Passion for Protein Crystallography

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Description:

We are recruiting a protein scientist with a passion for protein X-ray crystallography. Apply today if you thrive in an efficient and multi-disciplinary research environment focused on driving innovative drug programs forward. We give you the opportunity to develop both within and outside of your discipline.

SPRINT BIOSCIENCE IN SHORT

Sprint Bioscience develops small-molecule drugs to fight cancer. With fragment-based drug design methods, advanced technical approaches, and leading specialists, we develop the drugs of the future - from the idea stage to a clinical candidate with the goal set at being "First-in-Class". Our business model is to identify and run drug development projects and license these in the preclinical phase to the global pharmaceutical industry. We choose projects with the greatest technical and commercial potential for success. Sprint Bioscience has had a yearly growth since our start in 2009. Today, we are about 30 committed employees who work closely together in a stimulating environment with cutting-edge methodology and challenging projects. We also collaborate with several academic and industrial partners from all over the world. We are situated in tailored designed premises in Flemingsberg - Huddinge, 20 minutes by train from Stockholm City.

ABOUT THE POSITION

You will be a member of the Structural Biology team, consisting of scientists with expertise in the different areas related to protein crystallography (recombinant protein expression and purification, crystallogenesis, structure determination). Your main goal will be to develop crystal systems which will allow the generation of high-resolution crystal structures of complexes between proteins from our portfolio and the compounds synthesized by our Medicinal Chemistry team. Because Sprint Bioscience favored hit-to-lead approach is Structure-Based Drug Design, this activity is essential in order to progress our molecules towards a drug-candidate. Depending on your competences, you could also take part in the further structure determination, model refinement and structural analysis steps. We work in efficient and dynamic project teams, which are adaptable and change depending on project priorities. This is a full-time permanent position.

YOU WILL MAKE A DIFFERENCE

You will bring your expertise into a team of dedicated scientists. You need collaborative skills and to communicate well when supporting parallel projects in a multi-disciplinary environment. Our company language is English.

Your main contributions in the field of Structural Biology will be:

  • Developing stable crystallization protocols suitable for the study by X-ray crystallography of protein-ligand complexes
  • Applying these protocols to deliver high-resolution diffraction data to support the chemistry programs. Optional: delivering 3D model to chemists and guiding them in their analysis
  • Sharing responsibilities in term of organization of the structural biology activities (organization of synchrotron sessions, maintenance of the equipment)
  • Implementing new workflows and new methods for protein crystallography and structural biology in general

To be successful in this position you will need:

  • An extensive experience and expertise in crystallization of soluble proteins and particularly of protein-ligand complexes
  • A passion for structural biology (protein crystallography) and particularly method development in the different fields of the discipline

Having knowledge and experience in the following fields will be considered as benefits:

  • Structure-based drug-design softwares
  • Fragment-screening by X-ray crystallography
  • Structure determination (from data collection to model refinement and analysis)
  • Protein purification and characterization
  • Methods in Structural Biology other than X-ray crystallography

You will be able to apply to the position by following the link below :

https://www.sprintbioscience.com/en/career/available-positions/experienced-scientist-with-a-passion-for-protein-crystallography/


[Post Date: November 1, 2021]


Crystallography Research Assistant Exscientia

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Description:

Description

Exscientia is at the forefront of Artificial Intelligence (AI) driven drug discovery. Our AI driven systems actively learn best practice from vast repositories of drug discovery data and are further enhanced with knowledge acquired from seasoned drug hunters. Our teams are passionate in the pursuit of excellence and at Exscientia you will enjoy a flexible, inspiring and dynamic working environment. Exscientia is an equal opportunity employer committed to building a culturally diverse team.

The Discovery Biology team in Exscientia is responsible for enabling small-molecule therapeutic projects by providing GPCR biology, protein production, biophysical and crystallographic capabilities. The team works on diverse target classes and strongly integrates with the Centaur Chemist AI platform to support the transformative efficiency improvements in clinical candidate discovery demonstrated with our systems.

We are looking to recruit a Research Assistant specialising in X-ray crystallography to support the discovery of new therapeutic molecules. The candidate's main responsibilities will include the crystallization of protein-small molecule complexes, the documentation of protocols and experimental results, the maintenance of the crystallization laboratory, the management of beamtime logistics and the support to the crystallography group operations.

You Will Have The Opportunity To:

  • Performing high throughput crystallization experiments on multiple protein targets with and without ligands.
  • Managing the crystallography laboratory materials (e.g. consumables, stock solutions, liquid nitrogen dewars refill) and updating the inventory database.
  • Raising purchase orders and submitting the ordering of the selected items.
  • Assist the dewar logistics and beamtime preparation.
  • Check the crystallography equipment performance liaising with the engineers for servicing and maintenance.
  • Support the crystallography team operations, preparing stock solutions and ad-hoc screens.
  • Attention to detail including good record keeping
  • To author high quality reports and data summaries.

Requirements

  • A demonstrable analytical approach to problem solving.
  • The ability to work as part of a team.
  • Flexible, adaptable and able to work across multiple projects.
  • Excellent interpersonal communication skills.
  • The ability to plan work in order to meet the assigned timelines

Desirable Skills:

  • Experience with high throughput crystallisation methods using robotics.
  • Knowledge of the structural biology techniques.
  • Previous work experience in an industrial or high-throughput environment.
  • Demonstrated ability to optimise workflows.
  • Experience and interest in working with automation/liquid handling.
  • Experience with LIMS/ELN systems.

Qualifications:

  • The successful candidate will possess a minimum of a strong first degree in the biological sciences or proven laboratory experience in the life sciences.
  • This is a full-time, permanent position, but flexible or reduced working hours will be considered for an exceptional candidate.
  • Applicants must be able to demonstrate proof of the right to work in the United Kingdom.

Benefits

  • Work together to make a positive contribution to patients by revolutionising the pharmaceutical industry through AI-driven discovery.
  • We will work with you to kick-start or further grow your career – from funding for professional development and conference attendance. To also ensuring you will have the opportunity to acquire valuable skills, work on problems that matter, and learn from world-class technical and scientific leaders.
  • Opportunity to join an inclusive, collaborative and intellectually stimulating culture
  • We will work with you to provide a highly competitive compensation as we continue to grow and thrive.
  • Our teams health and well-being is important to us which is why we provide private healthcare, life assurance, wellbeing and mindfulness support.
  • We offer a generous holiday allowance, provide flexible working and remote working to encourage all of our team to manage their own work, time and life.
  • When you are in the office, you will have access to a kitchen stocked with an endless supply of food for all employees along with plenty of break out areas so you can get to know the people you are working with. Some of the best ideas start with a coffee break!


[Post Date: November 1, 2021]


Crystallographer Exscientia

View the Job Posting Here

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Description:

Description

Exscientia is at the forefront of Artificial Intelligence (AI) driven drug discovery. Our AI driven systems actively learn best practice from vast repositories of drug discovery data and are further enhanced with knowledge acquired from seasoned drug hunters. Our team are passionate in the pursuit of excellence and at Exscientia you will enjoy a flexible, inspiring and dynamic working environment. Exscientia is an equal opportunity employer committed to building a culturally diverse team.

The Discovery Biology team in Exscientia is responsible for enabling small-molecule therapeutic projects by providing GPCR biology, protein production, biophysical and crystallographic capabilities. The team works on diverse target classes and strongly integrates with the Centaur Chemist AI platform to support the transformative efficiency improvements in clinical candidate discovery demonstrated with our systems.

We are looking to recruit an experienced scientist specialising in X-ray crystallography to support the discovery of new therapeutic molecules. The candidate will be responsible for the crystallization and the structure determination of protein-small molecule complexes by x-ray crystallography. The work will include crystallization, X-ray data collection, structure determination, and analysis.

You Will Have The Opportunity To:

  • Performing high throughput crystallization experiments on multiple protein targets with and without ligands.
  • Optimize the initial crystallisation hits to obtain stable reproducible crystal systems.
  • Implementation of the established techniques of crystal manipulation including ligand soaking, crystal cryo-protection and harvesting.
  • Regular use of synchrotron facilities to execute standard x-ray data collection.
  • X-ray fragment screening experiments.
  • Attention to detail including good record keeping
  • To author high quality reports and data summaries.
  • To communicate updates to project meetings. 

  • Represent Discovery Biology at scientific meetings.
  • To work to the highest scientific standards under the direction of the Head of Crystallography

Requirements

  • Minimum of a strong honours degree plus either a postgraduate qualification up to PhD degree or proven industry laboratory experience in the life sciences.
  • Experience with high throughput crystallisation methods for screening using robotics.
  • Know-how of strategy design for crystal conditions optimization.
  • Skill in crystal manipulation, including soaking, cryoprotection, crystal harvesting.
  • Experience in synchrotron source X-ray diffraction experiments, data collection optimization and beamtime preparation.
  • Proficiency with X-ray data processing, structure solution and refinement.
  • Knowledge of ligand chemical restraints definition and ligand structure refinement.
  • Excellent interpersonal intelligence
  • A demonstrable analytical approach to problem solving
  • The ability to work as part of a team.

Desirable Skills:

  • Understanding of all crystallographic methods (e.g. microbatch)
  • Comprehension of others structural biology techniques (e.g. SAXS and Electron Microscopy).
  • Experience in designing constructs for recombinant protein production of crystallographic targets.
  • Previous work experience in an industrial environment.

Benefits

  • Work together to make a positive contribution to patients by revolutionising the pharmaceutical industry through AI-driven discovery.
  • We will work with you to kick-start or further grow your career – from funding for professional development and conference attendance. To also ensuring you will have the opportunity to acquire valuable skills, work on problems that matter, and learn from world-class technical and scientific leaders.
  • Opportunity to join an inclusive, collaborative and intellectually stimulating culture
  • We will work with you to provide a highly competitive compensation as we continue to grow and thrive.
  • Our teams health and well-being is important to us which is why we provide private healthcare, life assurance, wellbeing and mindfulness support.
  • We offer a generous holiday allowance, provide flexible working and remote working to encourage all of our team to manage their own work, time and life.
  • When you are in the office, you will have access to a kitchen stocked with an endless supply of food for all employees along with plenty of break out areas so you can get to know the people you are working with. Some of the best ideas start with a coffee break!


[Post Date: November 1, 2021]


Protein Purification and Crystallization Expert

View the Job Posting Here

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Description:

The Northwestern Feinberg School of Medicine is seeking Two Protein Expression, Purification, and Crystallization Experts with an open rank for PostDoc, Research Associate, or Senior Research Associate to participate in a Structural Genomics Research Center addressing important biochemical studies related to infectious diseases. Protein targets are predominantly bacterial with some viral studies (included SARS-CoV-2) in topics of pathogenesis, antimicrobial resistance, and drug discovery.

https://www.feinberg.northwestern.edu/sites/csgid/

Duties will include design of plasmids for commercial synthesis, protein expression and purification, and protein crystallization. Crystallography experience is helpful although this person will work closely with experienced crystallographers and thus this crystallographic data collection and analysis is not essential.

Communication skills are important as person will work directly with persons from outside labs to pursue studies. Ability to work with other team members to create a positive working environment is essential.

Two positions will remain open until filled. One position will emphasize design and conduct of High Throughput/Multiplex protein purification and crystallization so HTP experience is helpful. One position will emphasize high priority community targets with possibility to conduct biophysics/drug discovery research studies to support findings in structures. Additional positions may open in spring/summer 2022 so candidates who do not expect to be available until mid 2022 encouraged to inquire now for future consideration.

It is expected that candidates will either hold a Ph.D. or have a minimum of six years relevant experience in protein purification and crystallization, preferably in a large center or company setting. More experienced candidates encouraged to apply. Salary will be set competitive with experience level.

Northwestern University is an Equal Opportunity, Affirmative Action Employer of all protected classes, including veterans and individuals with disabilities. Women, racial and ethnic minorities, individuals with disabilities, and veterans are encouraged to apply. Hiring is contingent upon eligibility to work in the United States.

Job Type: Full-time

Pay: From $52,000.00 per year

Benefits:

  • 401(k) matching
  • Dental insurance
  • Flexible spending account
  • Health insurance
  • Paid time off
  • Retirement plan
  • Tuition reimbursement
  • Vision insurance

Schedule:

  • Monday to Friday
  • Weekend availability

COVID-19 considerations:
Compliance with Northwestern COVID-19 policies will be mandatory for hiring. Please review the up-to-date policies at https://www.northwestern.edu/coronavirus-covid-19-updates/information-for/staff/index.html

Education:

  • Master's (Preferred)

Work Location: One location


[Post Date: November 1, 2021]


Research Associate Structural Biology of Genome Regulation University of Leicester

View the Job Posting Here

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Description:

We are looking for postdoctoral researchers to join our lab our lab at the Leicester Institute for Structural and Chemical Biology, UK. The positions are funded by a 5 year Wellcome Trust Investigator award to work on the regulation of gene expression and 3D genome organisation. For examples of recent work see Nature 578, 472–476 (2020); NSMB 27, 233–239 (2020); Nature 562, 538–544 (2018)

The successful candidates will use a multi-disciplinary approach that includes preparative biochemistry of multi-protein complexes, protein engineering and biophysical and structural techniques. The group is part of the Leicester Institute of Structural and Chemical Biology, UK. We have excellent access to state-of-the-art structural biology technologies including a Krios cryo-EM microscope

Please apply at: https://jobs.le.ac.uk/vacancies/2872/research-associate-structural-biology-of-genome-regulation.html

The advert closes on November 28, 2021.


[Post Date: October 27, 2021]


Postdoc AstraZeneca Gothenburg

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Description:

Postdoc Fellow: Developing protein-mimetic peptide therapeutics to modulate protein-protein interactions in cell signaling

Location: Gothenburg, Sweden

AstraZeneca is a global, science-led, patient-centered biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we're dedicated to being a Great Place to Work where you are empowered to push the boundaries of science and fuel your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society.

About the Postdoc Programme

Bring your expertise, apply your knowledge, follow the science, and make a difference!

AstraZeneca’s Postdoc Programme is for self-motivated individuals looking to take on exciting, high impact projects in a collaborative and innovative environment.

Working with peers and professionals from a diverse set of backgrounds, together with an elite academic mentor explicitly aligned to your project, you'll be respected as a specialist and encouraged to speak up. You'll lead a novel and innovative research project at the interface of drug discovery and biopharmaceutical development in a multidisciplinary scientific environment. You'll be empowered and supported to drive the success of your project, publish papers, achieve your goals and make a difference to our patients!

About the Opportunity

The goal of this postdoctoral project is to generate conformationally stable protein-mimetic peptides capable of modulating the formation of multi-protein complexes involved in cell signaling.

Protein-Protein Interactions (PPI) are important in the regulation of signaling pathways and modulation of PPI is a long-standing challenge in drug discovery. One strategy which has shown particular promise is the use of new chemical modalities such as protein-mimetic peptides. You will employ structure-based design to generate drug-like peptides as potential treatment for diseases related to malfunctioning cell signaling. The peptide-protein interactions will be characterized using X-ray crystallography and biophysical methods.

You will be working alongside Dr. Jenny Sandmark, (structural biology and biophysics) and Dr. Anaïs Noisier (peptide chemistry), at AstraZeneca Gothenburg and in collaboration with your academic advisor, Prof. David Craik (University of Queensland, Australia) who is a world-leading expert in the synthesis and structural characterization of conformationally stabilized peptides. You will be leading your own project in a multicultural environment and have access to state-of-the-art equipment and facilities.

This role will give you the opportunity to work across multiple teams and departments within AstraZeneca, thus gaining broad experience of the early drug discovery process. As a Postdoctoral Scientist working on developing protein-mimetic peptide therapeutics to modulate protein-protein interactions you will develop skills in a wide variety of areas including peptide chemistry, biophysics, protein expression, crystallography and learn about the fast-expanding chemical space of new drug modalities, such as peptides, oligonucleotides and drug-conjugates.

Qualification, Skills & Experience

Required:

PhD or postdoc experience in Structural Biology, Peptide Chemistry or Biochemistry.

The candidate should have a strong background in:

  • X-ray crystallography
  • Synthesis, purification and characterization of peptides 
  • The molecular biology and protein purification skills needed to produce high quality protein
  • A proven record of work, published in reputable scientific journals.

Preferably all of the above, but strong experience in one and willingness to learn new methods will suffice. Since the successful applicant is expected to perform most of the experimental work, relevant practical working experience is absolutely required.

Skills:

  • Ability to work independently and collaboratively.
  • Curious, self-driven, enthusiastic and resilient. 

Desirable:

  • Knowledge of techniques to conformationally stabilize peptides. 
  • Excellent communication skills.
  • Prior experience of working in a multidisciplinary project.

Are you already envisioning yourself joining our team? Good, because we can’t wait to hear from you.

Advert Opens: 19 October 2021

Advert Closes: 28 November 2021

This is a 3-year programme. 2 years will be a Fixed Term Contract, with a 1-year extension which will be merit-based.


[Post Date: October 26, 2021]


PostDoctoral Position in Membrane Protein Structural Biology at USC, Los Angeles

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Description:

The position is available starting immediately in the Department of Biological Sciences at the University of Southern California and is initially limited to 2 years, with possible extension.

Our research focuses on the structural biology of membrane proteins involved in synaptic transmission, using single particle cryoEM and X-ray crystallography, complemented by functional assays. We are working in close collaboration with the group of Prof. Vadim Cherezov (USC) on the structure determination of GPCRs. 

USC has a suite of research facilities and has recently commissioned a brand-new cryoEM facility:

  • CryoEM suite: Titan Krios with GIF Quantum energy filter and K3 detector, Glacios with Falcon 4 detector, Talos Arctica with CCD/side entry holder for NS and screening
  • Core facility for insect- and mammalian cell expression
  • High performance computing for data processing/analysis 

Qualified candidates must have a Ph.D. degree with a solid background in structural biology and biophysics/biochemistry. Previous work with membrane proteins is a plus. A successful candidate is expected to be highly skilled and self-motivated and is willing to work in a collaborative environment. The Postdoctoral salary depends on qualifications and relevant experiences according to USC standards. 

Interested candidates should apply directly with Cornelius Gati at gati[at]usc.edu. Please attach a cover letter, Curriculum Vitae, research statement, publication list and a reference letter. There is no deadline for this posting and applications will be evaluated on a rolling basis.

Current group website: https://dornsifecms.usc.edu/labs/gati-lab/

Recent work from our group includes:

H Shaye, A Ishchenko, JH Lam, GW Han, L Xue, P Rondard, JP Pin, V Katritch, C Gati*, V. Cherezov*

Structural basis of the activation of a metabotropic GABA receptor. Nature. 2020.

S Rempel, C Gati*, M Nijland, C Thangaratnarajah, A Karyolaimos, JW de Gier, A Guskov*, DJ Slotboom*.

A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds. Nature. 2020.


[Post Date: October 26, 2021]


Research Associate University of Birmingham - School of Biosciences

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Description:

Full Time FTC for 5 years 

Closing date – 30.11.2021

Role/Project Background

The research group to which the post is associated uses integrative structural biology to understand functional mechanisms of proteins, nucleic acids and their complexes. The Research Associate will express and purify functional proteins, produce nucleic acids either by in vitro transcription or chemical synthesis, reconstitute large biomolecular particles from recombinant material, study the biomolecular complexes with biophysical and biochemical experiments and establish functional tests in vitro. The material produced and studied by the Research Associate will then be used for structural biology experiments. The day-to-daywork includes cloning, bacterial cell culture, protein expression and purification, RNA transcription and purification, RNA and protein engineering, biophysical studies of biomolecules and of their mutual interactions, for example through Isothermal Titration Calorimetry, Multiple Angle Light Scattering and Electrophoretic Mobility Assays. In addition, the RA will help with laboratory management tasks.

Main duties

  • ·       Collect research data; this may be through a variety of research methods, such as scientific experimentation (as described above) and literature reviews
  • ·       Analyse research data as directed
  • ·       Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
  • ·       Develop or adapt techniques, models and methods
  • ·       Provide guidance as required to support staff and any students who may be assisting with research
  • ·       Deal with problems that may affect the achievement of research objectives and deadlines
  • ·       Carry out administrative tasks related directly to the delivery of the research
  • ·       Promote equality and values diversity acting as a role model and fostering an inclusive working culture

Person Specification

  • Degree or equivalent in Biochemistry, Biophysics or Molecular Biology 
  • Proficiency in protein recombinant expression and purification and/or in RNA synthesis and purification 
  • Practical experience in a biochemical laboratory
  • Experience in some of the biophysical techniques mentioned above
  • Skills in analysing data
  • Ability to analyse information and communicate effectively
  • Ability to access and organise resources successfully
  • Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day-to-day activity in own area that those with protected characteristics are treated equally and fairly


[Post Date: October 25, 2021]


Postdoc & Technical Positions Brown University

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Description:

The Deaconescu Lab at Brown University has one opening for a postdoctoral researcher and one for a technician. The laboratory's interests lie primarily in stress responses, with particular emphasis on responses to DNA damage. We utilize a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, electron microscopy). Examples of recent work are: Schwartz et al, Protein Science (2021), Brugger et al, Nature Communications (2020), Dorich et al, Genes & Development (2019), Vemu et al. Science (2018), Le TT et al. Cell (2018), Szyk et al, Cell (2014).

A successful postdoctoral candidate should have an established track-record of publications in peer-reviewed journals; solid experience with protein biochemistry (their purification and assay development). We have a variety of projects available at different stages of development, including some that involve drug design. Prior knowledge of crystallography and/or single-particle electron microscopy is highly desirable. Must be highly motivated and work well independently as well as in a team. Excellent spoken and written English are required. Newly minted PhDs are encouraged to apply.

A successful technician candidate should preferably have  a degree in chemistry/biological sciences and at least one year experience at the bench, at the minimum experience with molecular biology, and ideally, also with protein purification and crystallization.

Interested candidates should send a CV, a one page research experience summary and contact information for three references to alexandra_deaconescu[at]brown.edu. Please use “postdoctoral candidate” or “technician candidate" as a subject.

Salary and starting date are negotiable. Brown University, an Ivy League school ranked as 5th best in the US by the Wall Street Journal, is located in Providence, Rhode Island less than one hour away by train from Boston.   Rhode Island provides plenty of opportunities for outdoor recreation with beautiful beaches and sailing and we offer a friendly and supportive lab environment.

Lab webpage: https://deaconesculab.com


[Post Date: October 21, 2021]


Staff Position Advanced Technology Core for Macromolecular X-ray Crystallography at Baylor College of Medicine

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Description:

Description: A full-time, temp-to-perm staff position is available in the Advanced Technology Core for Macromolecular X-ray Crystallography at Baylor College of Medicine. The mission of the X-ray core is to assist researchers and physician-scientists in finding a structure solution of their macromolecule of interest. The successful applicant will assist with the robotic screening, imaging, evaluation, and optimization of macromolecular crystals to develop novel treatments against unmet human diseases. Experience with protein expression and purification is an advantage. The salary for this position is $38,830 per year in addition to a generous fringe benefit package. The position is ideally suited for a graduate with a Master's degree in a natural science (this is not a solicitation for graduate student trainees). The core laboratory is located on the main campus of Baylor College of Medicine, which provides a safe and secure environment for research. Social distancing and other safety precautions have been implemented and are maintained at all times.

Primary duties and responsibilities:

  • Assist with crystallization screening setups using a liquid handling robot.
  • Assist with imaging and recording of crystallization screening results.
  • Prepare biological buffers and chemical stock solutions.
  • Perform experiments in protein biochemistry.
  • Prepare figures and assist in writing reports related to experiments performed.
  • Maintain general lab environment (i.e., organization and cleanliness of the lab).
  • Maintain and ensure compliance with biosafety regulations.

Preferred qualifications:

  • Required: A Master's degree or Bachelor's with 2 years of related lab experience.
  • Desired: Prior experience with protein purification or biochemistry techniques.
  • Ability to keep accurate records of work performed is essential.
  • Strong organizational and communication skills.
  • Strong work ethic: ability to prioritize tasks, use good judgment, and complete duties.
  • Able to work independently and as a team.
  • Willingness to learn new techniques.

To apply, please send a cover letter and current CV with contact information for two referees to the core director, Dr. Sukyeong Lee (atc-xraycore@bcm.edu). Highly motivated researchers with excellent communication skills are encouraged to apply. Baylor College of Medicine is an equal opportunity employer.

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[Post Date: October 21, 2021]


Research Scientist UCB

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Description:

To strengthen our Protein Production Group, based in Slough UK, we are seeking a talented individual to fill the position of Research Scientist

Role overview

The Protein Production Group provides support for all NBE & NCE projects from early stage target validation through to those undergoing pre-clinical evaluation, by generating recombinant protein reagents for immunization, structural studies, assays and compound screening.  All reagents produced undergo biophysical analysis in order to enhance our understanding of their stability and solubility.  You will be part of the Protein Production Group playing a key role in project success by generating high quality protein reagents in a timely manner. You will also assist with antibody discovery.

The successful candidate will have the opportunity to rapidly impact on a wide range of our NBE & NCE projects, and to significantly contribute to the progression of these projects into the clinic and beyond.

Primary responsibilities

  • You will be responsible for expressing and purifying high-quality recombinant protein reagents to support UCB’s novel world-leading antibody and NCE drug discovery platforms for a variety of exciting therapeutic projects.

  • You will perform phage display experiments for the discovery of antibodies

  • You will use your excellent practical skills, communication and team working abilities to drive innovative projects forward from the laboratory.

  • You will be responsible for clearly presenting work and engaging in discussion in a variety of cross-functional and external collaborator meetings.

Essential experience

Candidates may be fresh PhD holders with relevant experience, or Bachelor/MSc degree holders currently working as skilled Research Scientist, within the Biopharmaceutical or Pharmaceutical industry.  Possess an inquisitive and innovative nature and a passion for delivering innovative new medicines for patients suffering with serious disease.

We are looking for candidates who are fully independent and competent in the following skill sets;

  • Molecular Biology (DNA manipulation techniques and use of VNTI and/or other DNA analysis software).

  • Protein Expression in coli, insect cell and Mammalian cell systems.

  • Protein Purification (Affinity, Ion Exchange, Hydrophobic Interaction Chromatography, Size Exclusion Chromatography, Analytical SEC, UV-Vis spectroscopy, protein refolding techniques and extensive working knowledge of AKTA purification platforms and associated software)

  • Protein Analysis (SDS PAGE, HPLC, ELISA, Western blotting)

  • Molecular Visualisation of proteins (PyMOL or similar).

  • Ability to work on several projects and conduct experiments in parallel.

  • Proficiency in the use of Microsoft Office.

  • A highly motivated individual with a proven ability to deliver to tight timelines.

  • A team player, with good organisational, communication, record keeping and inter-personal skills are essential requirements. 

  • Presentations within the group and to project teams will also be expected. 


[Post Date: October 21, 2021]


Senior Scientist - Protein Biochemist UCB

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Description:

To strengthen our Protein Production Group, based in Slough UK, we are looking for a talented individual to fill the position of Senior Scientist - Protein Biochemist

Role overview
The Protein Production Group provides support for all NBE & NCE projects from early stage target validation through to those undergoing pre-clinical evaluation, by generating recombinant protein reagents for immunization, structural studies, assays and compound screening.  All reagents produced undergo biophysical analysis in order to enhance our understanding of their stability and solubility.  You will be part of the Protein Production Group playing a key role in project success by generating high quality protein reagents in a timely manner. You will also assist with antibody discovery. 

The successful candidate will have the opportunity to rapidly impact on a wide range of our NBE & NCE projects, and to significantly contribute to the progression of these projects into the clinic and beyond.

Primary responsibilities

  • You will be responsible for expressing and purifying high-quality recombinant protein reagents to support UCB’s novel world-leading antibody and NCE drug discovery platforms for a variety of exciting therapeutic projects.
  • You will have an excellent and proven track record of protein reagent delivery.
  • You will use your excellent practical skills, communication and team working abilities to drive innovative projects forward from the laboratory.
  • You will be responsible for clearly presenting work and engaging in discussion in a variety of cross-functional and external collaborator meetings.

Essential experience
Candidates will have extensive experience (PhD holder or graduate with 4-5 years) in protein biochemistry, focusing on recombinant protein production, preferably in an industrial environment 

We are looking for candidates who are fully independent and competent in the following skill sets:

  • Molecular Biology (DNA manipulation techniques and comprehensive knowledge and experience with software used in manipulating protein and DNA sequences (VNTI) and molecular visualisation of proteins (PyMOL or similar).
  • Proficient in E.coli, insect and mammalian cell expression systems and experience in 15N, 13C and 2H labelled expression in E.coli.
  • Fully independent in protein purification techniques (affinity, ion exchange, hydrophobic interaction chromatography, size exclusion chromatography, analytical SEC, UV-Vis spectroscopy, and protein refolding techniques) and extensive experience working with AKTA purification platforms and associated software.
  • Fully competent in protein characterisation techniques: SDS-PAGE, Western blot, analytical SEC, UV-Vis spectroscopy and UPLC.
  • Excellent biochemistry knowledge with hands on experience of protein labelling and characterisation.
  • Good understanding of recombinant protein expression systems and the molecular biology involved in generating expression constructs.
  • Thorough knowledge of the latest technologies involved in protein purification.
  • Track record of recombinant protein production covering multiple protein classes including enzymes, structural proteins, cell signalling factors, cell surface receptors and their ligands produced as intracellular and secreted proteins. 
  • In addition to experience with soluble proteins, preference will be given to candidates with experience in membrane protein production.
  • Ability to work on several projects and conduct experiments in parallel.
  • A highly motivated individual with a proven ability to deliver to tight timelines.
  • A good team player, with strong organisational, communication, record keeping and inter-personal skills. 
  • A scientist with an inquisitive and innovative nature and a passion for delivering innovative new medicines for patients suffering with serious disease. 


[Post Date: October 21, 2021]


Postdoc Rutgers University

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Description:

We have an immediate opening for a skilled post-doctoral researcher in the laboratory of Prof. Eddy Arnold at Rutgers University (NJ, USA). The aim of the project is to study the structure and function of human viral proteins, mainly polymerases from HIV-1, SARS-CoV-2 and other RNA viruses posing a pandemic threat, through X-ray crystallography and cryo-electron microscopy.

For more information about the position, please see the full advert: https://jobs.rutgers.edu/postings/145198

Interested candidates should apply via the above link.


[Post Date: October 21, 2021]


Postdoc Loschmidt Laboratories Faculty of Science, Masaryk University

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Description:

Seeking for a highly motivated scientist for a postdoctoral position to investigate the mechanisms of Alzheimer’s disease and drug design at Loschmidt Laboratories, Masaryk University & St. Anne's University Hospital, Brno, Czech Republic.

More information is in the attachment and link.

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[Post Date: October 21, 2021]


Associate Director, Protein Science Roivant Sciences

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Description:

At Roivant, we are passionate about discovering and developing new drugs to impact patients’ lives. Since its inception in 2014, Roivant has launched over 20 portfolio companies (Vants), overseen 5 successful IPOs, established a $3B partnership with a global pharma, built a pipeline of over 40 assets across various modalities and therapeutic areas, and delivered 8 successful phase 3 readouts.

Roivant’s drug discovery capabilities are driven by our computational discovery platform, which combines preeminent physics-based tools with deep expertise in machine learning to generate unprecedented analytical power that can tackle previously intractable discovery challenges. The tight integration of this computational platform with our experimental capabilities enables the rapid design and optimization of new drugs to address a wide range of targets for diseases with high unmet need.

We believe that the future of drug discovery lies in integrating predictive sciences, biology and medicinal chemistry to accelerate the path to new medicines. This role is an opportunity to be an architect of this paradigm shift and generate transformative benefit for patients.

Position Summary: 

Roivant Discovery is looking for an experienced leader responsible for guiding, growing, and managing the Protein Sciences/Advanced Expression Technologies team. The successful candidate will provide scientific and leadership support to the team, help prioritize allocation of resources, and oversee the development of the scientific & operational infrastructure required to meet Roivant Discovery needs in the protein sciences arena. Some of the key desired attributes of the successful candidate include the demonstrated success in expression and purification of difficult proteins and the ability to design, orchestrate, and execute complex experimental designs in the context of multi-disciplinary teams. Working closely with other researchers in our drug discovery organization, the candidate will advance our protein expression and purification capabilities to match the needs of our growing Discovery portfolio.   

Responsibilities:  

  • Lead the cross-functional Protein Sciences team, providing strategic and technical leadership in construct engineering, protein expression, purification, and characterization
  • Establish state of the art expression methods to address challenging protein targets
  • Drive the evergreen process of keeping the internal protein expression and purification technologies on the cutting edge of the current science and technology
  • Oversee outsourcing activity of CROs including protocol transfer, protein production, and QC
  • Build a culture of personal accountability, teamwork, and mentorship that supports the professional development of direct reports and others

 Required Qualifications:  

  • PhD and/or post-doctoral training in protein science - biochemistry, molecular biology, biophysics, structural biology, or related field
  • 10+ years of relevant biotechnology or pharmaceutical industry experience in protein engineering, biochemistry, and structural biology.
  • 5+ years of experience building, managing, and leading teams to successfully meet objectives supporting the organization, its people, and patients
  • Deep practical knowledge and recent hands-on expertise in the areas of construct design, protein expression, protein purification, and protein analytics
  • Good understanding/appreciation of protein quality parameters required for the successful application towards structural studies, biochemical assays, and biophysics

Desired Qualifications:

  • Preference will be given to candidates with proven track record of leadership and a strong scientific background in protein expression, protein enzymology, biochemistry, structural studies
  • Deep expertise in bacterial, insect, and mammalian cell culture techniques for the purposes of protein production
  • Detail-oriented with excellent organizational and communication skills
  • Must enjoy working in a fast-paced dynamic and highly collaborative environment
  • Excellent collaboration, communication, and interpersonal skills are required to work with cross departmental teams/functions to drive drug discovery projects
  • In-depth knowledge of molecular biology & modern cloning techniques

Roivant Sciences provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.


[Post Date: October 19, 2021]


Senior or Lead Researcher (Structural Biologist)

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Description:

The lab of Dr. Taosheng Chen is recruiting a Structural Biologist to join the efforts in structural determination of protein-ligand complexes and contribute structural biology insights into the mechanism of action of novel chemical probes. The Chen Laboratory (https://www.stjude.org/chen) uses multidisciplinary approaches to study transcriptional regulation by nuclear receptors, including chemical biology approaches to develop chemical modulators, with a goal to understand nuclear receptor-regulated transcription networks and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models. The structural biology efforts are expected to synergize with our chemical biology efforts and enable completion of impactful projects (Nat Commun 8:741, 2017; J Am Chem Soc2021, DOI: 10.1021/jacs.1c07066). The Chen Laboratory provides a unique research environment: in addition to basic research, lab members will learn and gain experience in small molecule drug discovery from target validation, chemical probe discovery and optimization to preclinical mechanistic studies. The Senior or Lead Researcher will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists, and technologists. 

The successful candidate will have proved experience in expression construct design, molecular cloning, protein expression and purification, optimization of crystallization conditions, crystallization and structural determination of protein-ligand complexes using X-ray crystallography. 

Experience in the following areas is a plus: purification and crystallization of nuclear receptors; synchrotron data collection; biophysical assays; in silico modeling of protein-ligand interactions; preparation of manuscripts; along with a strong publication record. 

Please direct your inquiries and current CV to Dr. Taosheng Chen (taosheng.chen@stjude.org) or apply online (https://careers-stjude.icims.com/jobs/8708/sr-researcher/job?hub=15&mobile=false&width=1180&height=500&bga=true&needsRedirect=false&jan1offset=-360&jun1offset=-300 ).

Minimum Education

Bachelor's or Master's degree in biology, chemistry, or a related field required. PhD in structural biology is essential, and relevant postdoctoral training is preferred.


[Post Date: October 18, 2021]


Postdoctoral Fellow, Structural Biology and Biophysics

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Description:

ROLE SUMMARY

We are seeking an enthusiastic and driven postdoctoral fellow to join the Structural and Molecular Sciences (SMS) Department at the Pfizer campus in Groton, Connecticut. This fellowship offers the unique opportunity to learn about the drug and vaccine development process in the laboratories of an innovative industry leader. The successful candidate will receive state-of-the-art training in protein structural biology and biochemistry with access to unparalleled resources supporting prokaryotic and eukaryotic protein expression, purification, and structure determination by X-ray crystallography or cryo-EM. At SMS, we have regular access to all the major synchrotron beam lines in the world and dedicated in-house cryo-EM facilities.  Ideal candidates will have experience in molecular biology, protein expression, protein purification, and structure determination.

ROLE RESPONSIBILITIES

  • Purification and assembly of challenging protein-protein, protein-RNA and protein-small molecule complexes

  • Iterative design and cloning to generate protein expression constructs

  • Determine the structure of a functional complex to by X-ray crystallography or cryo-EM

  • Structural analysis to generate and test hypotheses

  • Functional characterization of protein complexes by biophysical and biochemical methods

  • Collaboration across departments

  • Critical reading of the relevant literature

  • Manuscript preparation and presentation of results in oral and poster formats

BASIC QUALIFICATIONS

  • PhD in Structural Biology or Biochemistry with experience in the gene-to-structure pipeline

  • Construct design and molecular biology skills

  • Extensive experience in protein expression and purification

  • Experience with structure determination by X-ray crystallography and/or cryo-EM

  • Strong track record of publication in peer-reviewed scientific journals

  • Excellent verbal and written communication skills

PREFERRED QUALIFICATIONS

  • Experience in biophysical and biochemical assay development


[Post Date: October 13, 2021]


Biochemist Sosei Heptares

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Description:

Company Description

Sosei Heptares (the corporate brand of Sosei Group Corporation) is a research-focused biotechnology group, publicly listed in Japan (TSE: 4565) and with sites in Tokyo, London and Cambridge (UK).

Our mission is to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected technology and platform.

Our primary focus is the discovery and early development of new medicines originating from its proprietary G Protein-Coupled Receptor (GPCR)-targeted StaR® technology and Structure-Based Drug Design (SBDD) platform capabilities. The company is advancing a broad and deep pipeline of novel medicines across multiple therapeutic areas, including CNS, immuno-oncology, gastroenterology, inflammation and other rare/specialty indications.

We have established partnerships with some of the world’s leading pharmaceutical companies, including Allergan, AstraZeneca, Daiichi-Sankyo, Genentech (Roche), Novartis, Pfizer and Takeda and additionally with multiple emerging technology companies

Sosei Heptares has approximately 161 employees based at its new R&D research facility at Granta Park. The size of the company ensures a transparent linkage between all activities from early discovery through to clinical development.

Position

We are now seeking a membrane protein biochemist to join the Biochemistry group at our research facility on Granta Park, Cambridge, UK, working on membrane protein biochemical characterisation to enable drug discovery efforts.

At Sosei Heptares we are equipped with state-of-the-art protein expression, purification, SPR, mass-spectrometry, crystallisation and cryoEM facilities. Applicants should have experience in the expression and purification of challenging membrane proteins destined for biochemical, biophysical and structural studies. Applicants with a proven track record of publications related to the expression, purification, and biochemical characterisation of difficult membrane protein targets in peer-reviewed journals would be advantageous.

This is an exceptional opportunity to participate in pioneering science with an industry-leading drug discovery company.

The successful candidate is expected to:

  • Express and purify membrane proteins
  • Perform appropriate quality control analyses and biochemically and biophysically characterise purified membrane proteins
  • Keep up to date, propose, develop, implement and optimise new techniques in the fields of membrane protein expression, purification and biochemical characterisation
  • Work together with scientists responsible for successfully progressing membrane protein targets through Sosei Heptares’ structure-based drug design pipeline
  • Collaborate with other Sosei Heptares scientists on research projects, working closely with molecular biologists, biophysicists, structural biologists, molecular pharmacologists, computational and medicinal chemists
  • Prepare and effectively present results (written and oral) to project teams
  • Have strong interpersonal skills and interact effectively with collaborators across a wide range of disciplines

Requirements

The preferred candidate will have the following:

  • A PhD in biochemistry, biophysics or a related discipline
  • Experience in membrane protein expression, purification and characterisation in either an academic or industry setting
  • Good molecular biology skills
  • Knowledge in prokaryotic and eukaryotic expression vectors
  • Knowledge in expression construct design and engineering to successfully express membrane proteins destined for biochemical, biophysical and structural studies
  • Expertise in the expression of membrane proteins from mammalian and insect cells
  • Expertise in the purification and extensive biochemical characterisation of membrane proteins
  • Experience in the reconstitution of purified membrane proteins in membrane-mimetic environments
  • Familiarity with biochemical and biophysical techniques used to characterise membrane proteins such as luminescence, fluorescence and FRET-based techniques
  • Understanding of the requirements of purified membrane proteins destined for structural (X-ray and/or CryoEM) and biophysical studies (SPR, mass spectrometry)
  • Excellent organisational skills

Other information

The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation.

We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes.

Applications should include a covering letter, providing a short description of the background to their interest in the role, with curriculum vitae including the names and contact details for two referees. Please apply through our on-line jobs’ portal with your application in pdf format, quoting reference number 2021-RS-1BMS.

The closing date for applications is 31st December 2021.

Sosei Heptares does not accept speculative or unsolicited CVs from agencies. All speculative or unsolicited CVs submitted without an agreement in place will be considered Sosei Heptares' property and will not obligate us to pay a referral fee.


[Post Date: October 13, 2021]


Postdoc St Jude Children Research Hospital (Memphis, TN)

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Description:

The Cupido lab at St Jude Children Research Hospital (Memphis, TN) is seeking postdoctoral fellows who wish to conduct structural and chemical biology research and gain experience as independent researchers. These positions are core funded and the expected start date will be in January 2022 but can be flexible.

Candidates should have expertise in biochemistry and structural biology. Programming and/or bioinformatic experience in data analysis is preferred. Successful applicants are expected to lead projects and gain multidisciplinary training in cutting edge structural and molecular technologies. This is a great opportunity for enthusiastic postdocs, who will be encouraged to integrate different experimental approaches and take full advantage of the outstanding scientific technology platforms at St Jude, including dedicated, state-of-the-art centers for Cryo-EM, X-Ray crystallography, biomolecular NMR, and high-throughput chemical and genomic screenings, among others.

About The Lab
The Cupido lab opened on January 2021 in the Department of Chemical Biology & Therapeutics, is well equipped for biochemistry and chemical biology research and has full access to unparalleled research resources and expertise in an open and collaborative environment at St Jude. Our research focuses on discovering drug-like chemical modulators for protein machines and for the analysis of molecular mechanisms that control the flow of genetic information (i.e. gene transcription and mRNA splicing). Our efforts are highly multidisciplinary, integrating structural and genomic approaches with small molecule chemistry. One major focus is to understand the mechanism and regulation of nucleic acid-interacting enzymes whose aberrant function is implicated in cancer development. We seek to control the dynamics of these protein machines using small molecules we design, identify new pharmacological approaches, and test hypotheses for the development of novel cancer therapeutics.

To apply, please send a cover letter emphasizing research background and career goals, and a CV to tommaso.cupido@stjude.org.


[Post Date: October 12, 2021]


Postdoc Institute of Structural and Molecular Biology in London, UK

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Description:

We have a postdoctoral position available at the Institute of Structural and Molecular Biology in London, UK. The Gouge lab (http://www.bbk.ac.uk/biology/our-staff/academic/jerome-gouge) is interested in fundamental processes regulating redox homeostasis. You will be involved in molecular and structural characterisation of large macromolecular complexes using cryo-electron microscopy and X-ray crystallography. This project presents unique opportunities to gain insights into basic mechanisms responsible for maintaining redox homeostasis, which can be deregulated in human diseases (https://pubmed.ncbi.nlm.nih.gov/34202320/, https://www.ncbi.nlm.nih.gov/pubmed/26638071 and https://www.ncbi.nlm.nih.gov/pubmed/28854119).

We are seeking a motivated and talented Postdoctoral Research Assistant to elucidate the molecular mechanisms underlying the activation and regulation of the oxidative stress response.

The ISMB (www.ismb.lon.ac.uk/electron-microscopy) is equipped with state-of-the-art Structural Biology facilities, including screening microscopes and a Titan Krios with a K3 camera.

Applicants should have a PhD, or about to be awarded, in Structural Biology, Biochemistry or Biophysics, and have relevant research publications.

To apply, please use the following link: https://cis7.bbk.ac.uk/vacancy/postdoctoral-researcher-459881.html and send me your CV at j.gouge@mail.cryst.bbk.ac.uk . The deadline is the 29th of October. For informal enquiries, don’t hesitate to contact me at j.gouge@mail.cryst.bbk.ac.uk


[Post Date: October 11, 2021]


Scientist, Structural Biology Plexxikon

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Description:

Plexxikon, a member of the Daiichi Sankyo Group, is a leader in the discovery and development of novel, small molecule pharmaceuticals. The company utilizes its proprietary discovery platform to successfully develop a portfolio of competitively differentiated clinical and preclinical stage compounds in a number of therapeutic areas. Plexxikon’s first marketed drug, Zelboraf™ (vemurafenib) was the first precision medicine to be approved for the treatment of BRAF-mutant metastatic melanoma.  Plexxikon's demonstrated capability in discovery and early development uniquely positions the company to develop multiple commercial franchises for different therapeutic indications, and to create significant value for Plexxikon, Daiichi Sankyo and its collaborators.  Plexxikon's novel discovery approach, combined with experienced management and scientific teams, a broad network of scientific and clinical experts, and partnerships supporting later stage development, have been key drivers of the company's success since it began operations in 2001.  Plexxikon is a small business with approximately 70 employees based in South San Francisco, California.

We are seeking a highly motivated structural biologist who is interested in drug discovery.  This position will be a critical member of the Structural Chemistry and Informatics team.  This is an exceptional opportunity to gain experience in structure-guided drug discovery in a successful biotech company.  

Responsibilities:

  • Carry out high throughput crystallization, synchrotron data collection and processing
  • Determine and interpret crystal structures of protein-ligand complexes, with emphasis on high quality ligand fitting
  • Collaborate closely and effectively with protein chemists, chemists and researchers across disciplines and serve as a resource for colleagues in a team environment
  • Prepare and deliver scientific presentations and reports to communicate structural findings to colleagues within and outside structural biology department
  • Influence discovery decisions and contribute significantly to corporate goals and project milestones
  • Maintain a command of relevant scientific literature, research and mine public domain structure data, and evaluate implications for internal projects
  • Assume responsibility for maintaining laboratory equipment, facilitate their use by other scientists, and maintain clear, detailed, and up-to-date experimental records
  • Conduct other duties as assigned

Position Requirements & Experience:

  • PhD in Structural Biology
  • 1-3 years post-graduate experience in independent research which may include post-doctoral training (new PhD with exceptional qualification will also be considered)
  • Extensive experience with macromolecule crystallization, synchrotron X-ray diffraction data collection, data processing, and structure determination and refinement
  • Understanding the principles and familiar with various phasing (MAD/SAD/MR) methods, density modification and model building techniques, refinement, and structure validation methods
  • Expert knowledge on protein purification, protein sample characterization and protein construct design for crystallography
  • In-depth knowledge of the principles of protein structure, conformational dynamics, protein-ligand interactions, and implications for drug design
  • Highly motivated and able to work in a fast-paced environment
  • Demonstrated technical proficiency, scientific creativity, and problem-solving ability

Excellent interpersonal, verbal, and written communication skills are essential in this collaborative work environment

  • Desire to learn and tackle new challenges is imperative


[Post Date: October 11, 2021]


Description:

A postdoctoral research associate position with competitive salary and benefit is available in Dr. Limei Zhang’s group for highly motivated candidates who are interested in structural biology, redox biology and/or infectious disease. The Zhang Group applies a suite of interdisciplinary tools to investigate the structure-mechanism relationships of proteins in redox reactions, stress responses and antibiotic resistance, with funding support from NSF and NIH. For more information about the Zhang Group, please visit the website: https://biochem.unl.edu/limei-zhang.

Job responsibility: We seek a postdoc to investigate the roles and underlying mechanism of metalloproteins in redox stress response and antibiotic resistance. The duties of the postdoctoral fellow include independently design and conduct high-quality research experiments for the assigned project under the supervisor’s guidance; analyze data and draft manuscripts for publication; take roles in the lab maintenance with other group members; and assist the supervisor to mentor undergraduate and graduate students.

Qualification: The required qualifications include a recent Ph.D. degree (or expected soon) in biochemistry, biophysics, chemistry, microbiology or a related field; a strong record in conducting high-quality research. Preferred qualifications include expertise in either biophysics, protein biochemistry or advanced molecular biology; excellent communication skills; ability to work cooperatively on multidisciplinary projects; and experience in mentoring.

The University of Nebraska-Lincoln is located in a vibrant and safe city offering an outstanding and affordable quality of life, and numerous multi-cultural and entertainment benefits. The Redox Biology Center is organized as a broad-based interdisciplinary and multi-institutional entity involving researchers from the University of Nebraska-Lincoln and the University of Nebraska Medical Center in Omaha, and offers a supportive and collaborative international environment as well as access to cutting edge proteomics, metabolomics, crystallography, and NMR facilities.

Recognizing that diversity within a context of inclusivity enhances creativity, innovation, impact, and a sense of belonging, the Institute of Agriculture and Natural Resources (IANR) and the Department of Biochemistry are committed to creating learning, research, Extension programming, and work environments that are inclusive of all forms of human diversity. We actively encourage applications from and nominations of individuals from underrepresented groups.

To apply for the position, please submit a letter of interest with a short summary of past research experience; your curriculum vitae, and contact information for three professional references, including phone numbers and emails to limei.zhang@unl.edu

As an EO/AA employer, qualified applicants are considered for employment without regard to race, color, ethnicity, national origin, sex, pregnancy, sexual orientation, gender identity, religion, disability, age, genetic information, veteran status, marital status, and/or political affiliation. See http://www.unl.edu/equity/notice-nondiscrimination.


[Post Date: October 11, 2021]


Associate Scientist II - Protein Sciences

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Description:

MD ANDERSON THERAPEUTICS DISCOVERY DIVISION

Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new targeted, immune- and cell-based therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery, with a multidisciplinary team of dedicated researchers, doctors, drug developers and scientific experts working together to develop small-molecule drugs, biologics and cellular therapies. Our unique structure and collaborative approach allow the team to work with agility, bringing novel medicines from concept to clinic quickly and efficiently – all under the same roof.

The Therapeutics Discovery Division is built around four platforms: The Institute for Applied Cancer Science (IACS), ORBIT (Oncology Research for Biologics and Immunotherapy Translation), TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology) and the Neurodegeneration Consortium.

The IACS platform is focused on discovering and developing the next generation of small-molecule targeted therapies, driven by the needs we see in our patients. The team aligns world-class drug discovery and development research with the science and clinical care for which MD Anderson is known. We work in a fast-paced, milestone-driven environment with a focus on team science and interdisciplinary research. Our unique approach has created a biotech-like engine within the walls of the nation's leading cancer center to bring life-saving medicines to our patients more quickly and effectively. This model already has achieved results, with multiple programs currently in clinical and late-stage preclinical development.

The Institute Associate Scientist II in the structural chemistry group of the Institute for Applied Cancer Science (IACS) participates in cross-functional research to advance our drug discovery projects from early exploratory efforts through lead optimization, ultimately delivering therapeutic agents of benefit to patients.  As part of the IACS team, the Institute Associate Scientist II will deliver high-quality protein samples for a variety of crucial applications, including in vitro assays, X-ray crystallography, and cryo-electron microscopy.

By joining the Therapeutics Discovery Division, you have the opportunity to use your talents to make a direct impact on the lives of our patients. We are seeking a highly motivated and collaborative individual to become a part of our team. The ideal candidate will have experience expressing and purifying recombinant proteins in one or more expression systems.

Key Functions

  1. Under moderate supervision, conduct laboratory experiments to express, purify, and characterize recombinant proteins to advance IACS projects.
  2. Conduct test expression experiments to identify optimal expression system (eg. E. coli, insect cell, mammalian) and conditions for protein production.
  3. Express recombinant proteins at multi-liter scale in an appropriate expression system.
  4. Purify proteins using Bio-Rad NGC FPLCs.
  5. Characterize purified proteins using biophysical methods (eg. nanoDSF, dynamic light scattering, ITC) to ensure suitable quality for downstream applications (eg. in vitro assays, structural biology).
  6. Presents research results to integrated drug discovery research project teams.
  7. Employ safe lab practices.
  8. Maintain research records and laboratory notes.

Education

Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.

Education Preferred: Master's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.

Experience

Required: One year of relevant research experience in lab. With preferred degree, no required experience.

Preferred:  Experience expressing recombinant proteins from E. coli, insect cell, or mammalian cell systems.  Experience with FPLC-based protein purification instruments.  Excellent communication, writing and organizational skills.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html


[Post Date: October 11, 2021]


Postdoc Structural Genomics Consortium University of Toronto

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Description:

UNIVERSITY OF TORONTO

POSITION TITLE: Postdoctoral Position – Limited Term

DEPARTMENT: Structural Genomics Consortium (SGC), Faculty of Medicine

SUPERVISOR: Dr. Levon Halabelian

OVERVIEW:

The Structural Genomics Consortium (SGC) in the Faculty of Medicine, University of Toronto invites applications for the Postdoctoral position (Limited Term) to join the SGC’s structural biology team to investigate the structure, mechanism and druggability of human WD-repeat (WDR) domain containing proteins using X-ray crystallography, biochemistry and biophysics. WDRs are protein-protein interaction hubs that are often found in key regulatory complexes involved in ribosomal biogenesis, epigenetic regulation, cell cycle control and DNA repair (see Schapira et al., 2017, https://doi.org/10.1038/nrd.2017.179), (Grebien et al, 2015, https://doi.org/10.1038/nchembio.1859) and (Getlik et al., 2016, DOI: 10.1021/acs.jmedchem.5b01630).

Many WDR proteins are associated with diverse neurodegenerative diseases including Parkinson’s Disease (PD), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD) and others. This project focuses on understanding the role of LRRK2 WDR domain in PD including disease-linked mutations and its potential for therapeutic modulation.

The successful candidate will have a broad knowledge of protein biochemistry and X-ray crystallography, a passion for scientific research as applied to drug discovery and be eager to work as a team player in a fast-paced multidisciplinary environment.

QUALIFICATIONS:

· Ph.D. in biochemistry, molecular biology, structural biology, or related field, with at least one first authored publication in an internationally recognised peer-reviewed journal.

· Strong experience with recombinant protein expression, and purification, is required.

· Experience in X-ray crystallography and/or cryo-EM is highly desirable.

· Experience with in vitro biophysical methods for protein-protein and protein-ligand interaction studies (e.g. DSF, SPR, FP, FRET and ITC) is valuable.

· Strong communication skills, particularly the visual presentation of structural data.

· Ability to work in a team, communicate, and give/receive constructive feedback and high attention to detail, excellent organizational and documentation skills.

· Experience in preparing manuscripts for submission to peer review publications/journals and presenting findings at meetings and conferences.

APPLICATIONS SHOULD BE SENT TO: hrsgctoronto@thesgc.org with the subject line “WDR Postdoc”. Position will remain open until filled.

About Structural Genomics Consortium The Structural Genomics Consortium (SGC) (https://www.thesgc.org/) is a global public private partnership dedicated to open science and that seeks to accelerate drug discovery by fostering collaboration among a large network of scientists in academia and industry and by making all research outputs openly available to the scientific community. The current SGC research hubs are in Canada, Germany, Sweden, the United Kingdom, and the United States.

The University of Toronto and its affiliated hospital research institutes comprise one of the largest and most productive centers of biomedical research in North America. Located in vibrant downtown Toronto, the University provides an outstanding opportunity for scientific research, and career development.

The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas.

All qualified incumbents are encouraged to apply; however, Canadians and permanent residents will be given priority.

The SGC as part of the Nuffield Department of Medicine is a family friendly department: http://www.ndm.ox.ac.uk/family-friendly

Closing Date: 
Friday 31st December 2021


[Post Date: October 6, 2021]


Postdoc Rice University, Houston, Texas

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Description:

A postdoctoral position is available in Dr. Yang Gao’s Lab (http://yanggaolab.blogs.rice.edu/) at Rice University, Houston, TX. Our lab studies enzymes and motors in DNA replication and repair. We combined biochemical, biophysical techniques with cryo-electron microscope and crystallography to investigate how the genomic DNA is replicated and maintained. Previous experiences with protein cloning, expression, and purifications are needed. Experiences in crystallography and cryo-EM are a plus but not stickily required. Candidates with experience in biochemical reconstitution and characterizations of large enzyme complexes are more than welcome.

Interested candidates please contact Yang at yg60@rice.edu for details.


[Post Date: October 4, 2021]


Postdoc Peptide-based PROTACS Interfaculty Institute of Biochemistry and the Max Planck Institute for Developmental Biology in Tübingen, Germany

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Description:

The Hartmann Lab ("Molecular Recognition and Catalysis") at the Max Planck Institute (MPI) for Developmental Biology and the Interfaculty Institute of Biochemistry (IFIB) in Tübingen, Germany, has an opening for a Postdoc position in peptide-based PROTACs (m/f/d, TV-L E13, 100%).


Targeted protein degradation via PROteolysis TArgeting Chimeras (PROTACs) is steadily gaining momentum as a key modality for future therapeutics. PROTACs recruit disease-relevant proteins for ubiquitination by specific E3 ligases, and our group has a long-standing interest in delineating the chemical ligand space of E3 ligases for the development of novel PROTACs. However, with the currently available small-molecule ligands, only a small subset of human E3 ligases can be addressed via the PROTAC approach. With peptide-based PROTACs mimicking natural degron motifs, we aim to overcome this limitation and enable an mRNA-based delivery. In a first step, we are using methods of protein design and directed evolution (E.g. phage display) to identify and refine suitable peptidic E3 ligase ligands. The postdoctoral researcher will work on the establishment of in-vitro ubiquitination systems, as well as on the validation of peptidic ligands and their subsequent refinement via directed evolution. 
We are looking for a highly motivated candidate who enjoys working both independently and as part of a team. Key requirements are a strong background in biochemistry and eukaryotic cell culture and a very solid understanding of structural biology in general. Prior experience with directed evolution methods is a strong plus. Our group is expanding from the MPI to the IFIB and the candidate will be located mainly at the latter. 


The position is initially limited to 18 months, with the possibility of extension, and is open immediately until a suitable candidate is found. Applications including a letter of motivation, detailed CV, brief description of previous work, publication record and the contact information of two referees should be sent to marcus.hartmann@tuebingen.mpg.de 
The University of Tübingen seeks to increase the number of women in areas where they are underrepresented and therefore explicitly encourages women to apply. Equally qualified applicants with disabilities will be given preference.  


The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. The Max Planck Society seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply. The Max Planck Society strives for gender equality and diversity. 

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[Post Date: October 4, 2021]


Postdoc KU Leuven, Belgium

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Description:

A post-doctoral position is available at the Laboratory of Prof. Chris Ulens, KU Leuven, Belgium (http://www.xtal.be). The research in the Laboratory of Structural Neurobiology is aimed at understanding the molecular mechanism of ligand-gated ion channels. Our methods rely on X-ray crystallography and cryo-EM in combination with electrophysiological recordings and fluorescence-based techniques. Our laboratory hosts an integrated macromolecular crystallization facility with a Mosquito crystallization robot and two RockImagers. We have access to a 200 kV Glacios microscope on campus as well as 300 kV JEOL CryoARM300 at the nearby EM facility in Brussels. Current projects are situated at the crossroads of structural elucidation and drug discovery of different pentameric ligand-gated ion channels.

We would like to recruit a post-doc with prior experience in cryo-EM or X-ray crystallography of membrane proteins. The position is open immediately and applications will be accepted until the position is filled. Applicants are requested to submit a CV with publication list and two references. E-mail to chris.ulens@kuleuven.be

Selection of recent publications:

A lipid site shapes the agonist response of a pentameric ligand-gated ion channel. Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan G, Nury H, Steyaert J, Baenziger JE, Ulens C. Nat Chem Biol. 2019;15(12):1156-1164. doi: 10.1038/s41589-019-0369-4.


Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site. Brams M, Govaerts C, Kambara K, Price KL, Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, Steyaert J, Ulens C. Elife. 2020;9:e51511. doi: 10.7554/eLife.51511.


The structural basis for an on-off switch controlling Gβγ-mediated inhibition of TRPM3 channels. Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, Crassous PA, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, Economou A, Rousseau F, Schymkowitz J, Philipp SE, Rohacs T, Ulens C, Oberwinkler J. Proc Natl Acad Sci U S A. 2020;117(46):29090-29100. doi: 10.1073/pnas.2001177117.


[Post Date: October 4, 2021]