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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Postdoc Structure-Based Cancer Drug Discovery - Astbury Centre, Leeds University

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Description:

There is an immediate opening at the Astbury Centre (University of Leeds, UK) for a versatile structural biologist to work on cancer drug discovery in a collaboration with the Northern Institute for Cancer Research at Newcastle University.

The position, which is funded for 2 years by Cancer Research UK (CRUK), is for development of small molecule inhibitors of the Ras activating protein, SOS. You will preferably be an experienced X-ray crystallographer, with complementary skills and expertise in other structural and biophysical methods, including NMR, SPR or ITC. The project will also involve implementation of cell-based assays in conjunction with the lab of Dr Darren Tomlinson (Leeds). Medicinal chemistry expertise and resource will be provided by our Newcastle collaborators (Prof Mike Waring).

The successful applicant will have access to the Astbury Centre’s excellent structural biology facilities including a state-of-the-art crystallisation suite and cryoprobe-equipped 950 MHz NMR.


[Post Date: November 12, 2019]


Postdoctoral position available at the Basque Centre for Biophysics (Bilbao, SPAIN)

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Description:

We are currently looking for a postdoctoral researcher to join our lab. Please see below for details:

OFFER – Postdoctoral Position (Two years)

DEADLINE: 4th of February, 2020 at 17:00 h CET or until position is filled.

WHERE – Basque Centre for Biophysics (Bilbao, SPAIN)

The Basque Centre for Biophysics is an international research center of excellence with the main aim of promoting a multidisciplinary research program in the field of Biophysics and its application in the areas of Biotechnology and Health, the center is a joint effort of the University of the Basque Country (UPV/EHU) and the Spanish National Research Council (CSIC).

Description of the position offered

The position is available in the Structural Microbiology Laboratory led by Dr. David Albesa-Jové at the Basque Centre for Biophysics (Bilbao, Spain). Our group was recently established and focuses on understanding the biological function of virulence factors and essential enzymes in human pathogenic bacteria. Please, see below for some recent publications. The laboratory is well equipped for all aspects of molecular biology, biochemistry, biophysics and crystallography. We also have regular access to synchrotron radiation at Diamond (UK) and ALBA (Spain) through BAG applications.

1.    Albesa-Jové* D, et al.: Structural Snapshots of α-1,3-Galactosyltransferase with Native Substrates: Insight into the Catalytic Mechanism of Retaining Glycosyltransferases.

Angew Chemie Int Ed 2017, 56:14853–14857. IF. 12.26 *corresponding author

2.    Planamente S, Salih O, Manoli E, AlbesaJové D, Freemont PS, Filloux A: TssA forms a gp6‐like ring attached to the type VI secretion sheath.

EMBO J. 2016, 35:1613–1627. IF. 11.23

3.    Albesa-Jové D, et al.: Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA

Nature Communications. 2016, 7:10906. IF. 11.89

4.    Albesa-Jové D, et al.: A native ternary complex in crystal reveals the catalytic mechanism of a retaining glycosyltransferase.

Angew Chem Int Ed Engl. 2015; 54(34): 9898-902. IF. 12.26

5.    Giganti D, Albesa-Jové D, et al.: Secondary structure reshuffling modulates glycosyltransferase function at the membrane.

Nature Chemical Biology. 2015, 11(1): 16–18. IF. 12.15

6.    Andrés A1, Albesa-Jové1 D, et al.: Structural basis of chitin oligosaccharide deacetylation.

Angew Chem Int Ed Engl. 2014, 53(27): 6882–6887. IF. 12.26 1equal contribution

Education and Experience Required

We are seeking a highly motivated individual with a strong background in structural biology, including protein expression and purification, protein crystallization, and X-ray crystallography. Outstanding postdoctoral candidates will also have the necessary support to apply for the Ikerbasque Fellows 2020 call. These 5-year Fellowships are directed to promising young postdoctoral researchers (applicants must have their PhD completed between 2009 and 2017) and are intended to offer a track towards independent research as a group leader. Ikerbasque Fellows in their 5th year can be assessed for permanent group leader positions. More details about the previous 2019 Ikerbasque Fellows call can be found here:

http://www.ikerbasque.net/sites/default/files/files/Ikerbasque_RF_2019_Call_Specifications.pdf

Contact: Please submit your application for the postdoctoral position through the Centre’s website (http://biofisika.org/contact/) indicating the following subject: Job Application: 52Albesa, and adding a cover letter, curriculum vitae, and contact information for three professional referees. Informal enquires can be directed to davidalbesa@gmail.com. Women are encouraged to apply.


[Post Date: November 5, 2019]


Senior Scientist and Research Associate Structural Biology Positions Open at Confo Therapeutics Gent/Brussels, Belgium

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Senior Scientist Structural Biology (GPCR; cryo-EM; Xrays; SBDD; Biophysics)

(Senior) Research Associate Structural Biology (GPCR; cryo-EM, protein tool generation, biophysical/biochemical screening)

We are looking for a highly motivated individuals to join our growing structural biology team as a specialist to lead and support our GPCR cryo-EM efforts. Confo has a unique technology which makes use of antibody VHH fragments or ConfoBodies™ to stabilize GPCRs in a particular biologically active conformation of interest as a superior starting point for protein structure determination and innovative H2L/SBDD process. Recently, Confo secured an exclusive license to the Megabody™ technology. Megabodies enable to produce high resolution cryo-EM structures of membrane proteins, overcoming current protein size limitations and potential preferential orientation issues in the study of GPCRs via cryo-EM. Confo is currently located on the Technology Park in Zwijnaarde/Ghent and on the VUB campus in Brussels. More information about Confo’s technology and strategy can be found on www.confotherapeutics.com.

Senior Scientist Structural Biology (Gent/Brussels)

http://confotherapeutics.com/career-201907-scientist-struct-biol.html

You should have Ph.D. in a field related to structural biology such as cell biology, biochemistry or biophysics. Experience in the membrane protein structural biology -- either or both x-ray crystallography and electron microscopy -- ideally at the postdoctoral level and/or industrial experience. Moderate or extensive EM experience is preferred. You should be an energetic team player with the ability to model enthusiasm and motivate others to excellence. Ambitious in growing to cryo-EM expert in the membrane protein field and a project leader in drug discovery projects.

(Senior) Research Associate Structural Biology (Brussels)

http://confotherapeutics.com/career-201901-RA-structural-biology.html

You should have an advanced degree (BSc/MSc) and at least 3 year experience in a related field in a biotech environment. You should be an expert in molecular biology, recombinant protein expression using insect/mammalian systems and purification methods. The ideal candidate would have also extensive experience in biochemical/biophysical characterization/screening and protein engineering. You should be highly collaborative, self-motivated and team-oriented individual.

Our offer is a competitive compensation package with extensive benefits; an entrepreneurial and stimulating working environment in a growing and ambitious biotech company; excellent career development opportunity, with exposure to all aspects of R&D in the company, with external collaborators and partners.

Do you have the right qualifications and are you up to the challenge of joining our team? Then forward a short motivation letter and your CV to veli-pekka.jaakola@confotherapeutics.com


[Post Date: November 4, 2019]


Bioinformaticists Postdoctoral Scholar

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Description:

We have a postdoc position available at LBNL to work on the development of computational approaches for twinned crystallographic data. This is an exciting opportunity to address a relatively common phenomenon in crystallographic data analysis for which there are currently limited twinning-aware approaches. The aim is to develop tools that impact substructure solution, molecular replacement, density modification and structure refinement.


[Post Date: November 4, 2019]


Postdoc IBCP, Lyon- France

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Description:

A 2 years postdoctoral position funded by the Agence National de la Recherche (ANR) is available in the group of Dr. Laurent Terradot (@LaurentTerradot ) in the Unit Molecular Microbiology and Structural Biochemistry (MMSB) of the Institut de Biologie et Chimie des Protéines (IBCP, CNRS-University of Lyon), Lyon, France.

We are interested in structure function of protein-protein complexes involved in Helicobacter pylori pathogenesis. This bacterium is a major human pathogen that can cause human diseases such as ulcers and gastric cancers. The position is dedicated to the understanding of Helicobacter pylori Type IV secretion system by the determination of several protein-protein complexes by X-ray crystallography or Cryo-EM. Preliminary data are already available for several protein samples.

For more information on the project see Koelblen et al., 2017; Bergé and Terradot, 2017; Bergé, Wakmsan and Terradot, 2017, Bats et al., 2018; Zhao et al., 2019.

The IBCP (www.ibcp.fr) is well equipped for cell biology, molecular biology and biochemistry and Structural Biology and belongs to a larger campus (Lyon Biopole; Center for Infectiology), giving access to state-of-the-art core facilities in areas. The group has regular access to synchrotron beam time and Cryo-EM. Lyon is a vibrant, historical French city and is a world-excellence center in infectiology.

Working language of the laboratory is English. We are looking for enthusiastic and self-motivated individuals with a strong background in protein purification and Structural biology. Experience in the study of complexes would be a plus. Knowledge in Macromolecular Crystallography and/or Cryo-EM would be considered an advantage but is not mandatory.

Proposed starting date: February 2020

Salary is according to the CNRS french guidelines and should be between 2500-3200 euros gross monthly according to experience.

Interested candidates must apply online on the CNRS website: https://emploi.cnrs.fr/Offres.aspx with a CV, reference letter(s) and a short summary of your experience/motivation.


[Post Date: October 31, 2019]


Postdoc Opportunities in Structural Virology at UNSW

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Description:

3 Postdoctoral Position in Sydney, Australia:
Structural Biology of HIV:host interactions and capsid uncoating

 We are seeking a 3 exceptional candidates for a postdoctoral positions in, protein crystallography, cryo-electron microscopy, and virology to better understand the how the HIV capsid responds to host molecules during the process of infection. We aim to apply a range of structural and virological methods to image model capsid systems and authentic viral capsids in the presence of externally applied recombinant cofactors and metabolites in order to understand the nature and regulation of the uncoating event. The data will build on our recently developed single molecule fluorescence methods for measuring HIV core stability and help complete our understanding of the multiple essential roles played by the capsid.

 The successful candidates will join our team of protein scientists, biophysicists, and virologists at the EMBL Australia Node in Single Molecule Science, University of New South Wales, Sydney, Australia (http://sms.unsw.edu.au) and the ARC Centre of Excellence in Advanced Molecular Imaging (http://www.imagingcoe.org). The postdoctoral researchers will have an active role in conceiving and implementing approaches, training and supervision of research staff and students and presentation of the results in the form of publications, international conference presentations and potentially grant applications.

 The postdoctoral positions are a full-time fixed term position available for 12 months from January 2020 onwards with strong prospects for a 2-year extension. Salary range is A$95,449-A$102,091 per year.

 For queries, please contact Dr David Jacques at d.jacques@unsw.edu.au, or apply online:

 https://external-careers.jobs.unsw.edu.au/cw/en/job/498123/postdoctoral-fellows-x-2-cryoelectron-microscopy-protein-crystallography

 https://external-careers.jobs.unsw.edu.au/cw/en/job/498122/postdoctoral-fellow-virology


[Post Date: October 31, 2019]


Postdoc Structural Biology of Membrane Remodeling

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Description:

A NIH-funded postdoctoral position is available immediately in the Ramachandran Lab at Case Western Reserve University (CWRU) to study the structural aspects of protein-mediated membrane remodeling during endocytic and mitochondrial membrane fission. The position requires a Ph.D. in biochemistry or biophysics with a strong focus on structural biology (X-ray crystallography, NMR, or cryo-EM) and membrane biophysics. This position will provide an excellent opportunity to learn and apply a wide array of structural and biophysical techniques to explore protein function in and on membranes. The Ramachandran laboratory also employs a host of cutting-edge spectroscopic approaches including FRET, fluorescence correlation spectroscopy (FCS) and fluorescence lifetime imaging (FLIM) to explore protein-protein and protein-membrane interactions in membrane remodeling and fission, both in vitro and in vivo. The Ramachandran lab and the facilities at CWRU are equipped with state-of-the-art instrumentation for structural biology, including a newly acquired 300 kV Titan Krios G3i microscope coupled to a Gatan K3 direct detection camera for high-resolution cryo-EM.

Requirements: Applicants must be highly motivated and must have demonstrated experience (i.e. relevant publications) in protein biochemistry and structural biology. The candidate should have a strong conceptual and experimental background in biochemistry and biophysics, as well as in the mechanistic dissection of structure-function relationships in proteins; he/she should be independent, proactive, hardworking and productive; only candidates that have first-author publications (or articles in press) will be considered. Candidates must have completed their PhD at the time of appointment. Salary will commensurate with experience and will adhere to current NIH guidelines. Interested candidates should submit their CV, reprints of selected publications, three reference letters (directly from referees), and a cover letter summarizing their experience, long-term goals, and estimated start date directly to Rajesh Ramachandran at rxr275@case.edu.

Relevant Publications. Please visit our webpage at https://physiology.case.edu/people/faculty/rajesh-ramachandran/


[Post Date: October 31, 2019]


Research Associate

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A RESEARCH ASSOCIATE POSITION (MSc or PhD) is available at Baylor College of Medicine in Houston, TX in the research group of Professor Francis Tsai. The successful candidate will join a multi-disciplinary team investigating the structures and mechanisms of stress-response proteins in protein quality control. We combine structural analysis techniques with biochemistry to understand mechanisms to maintain proteostasis in health and disease. The successful candidate must be highly motivated and will have proven expertise in biochemistry or structural biology. You must hold a MSc or PhD in biochemistry, enzymology or structural biology and have a demonstrated track record in conducting high quality original research. Experience in molecular biology and protein expression/purification is essential and knowledge in biochemistry and/or protein crystallography at the postgraduate level is desirable. Salary for postdoctoral applicants is commensurate with experience and pegged to the current NIH scale.

For further information and informal enquiries please contact Professor Francis Tsai https://www.bcm.edu/research/labs/francis-tsai. To apply, please send your CV, description of research experience and contact information for three referees to ftsai@bcm.edu.


[Post Date: October 29, 2019]


Postdoc positions at Imperial College London with Prof. Dale Wigley

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Description:

Job Advertisement Title: Research Associate in Structural Biology

Salary: £40,215 - £47,579

Location: South Kensington Campus

Job Summary

We are recruiting for two Research Associates in the Section of Structural Biology at South Kensington in the research group of Professor Dale Wigley (https://www.structurebiomed.org/dale-wigley). The successful candidate will join a multi-disciplinary team of international researchers investigating the structures and mechanisms of chromatin modifying complexes in human DNA damage repair and cancer. We combine structural biology techniques with biochemistry to understand molecular mechanisms for DNA repair that prevent cancer in humans. The successful candidates will have proven expertise in either or both of these areas.

You must hold a PhD, or equivalent, in biochemistry, enzymology or structural biology and have a demonstrated track record in conducting high quality original research. Knowledge at postgraduate level in structural biology (crystallography or electron microscopy) and/or biochemistry is essential and experience in expression/purification of multi-protein complexes in insect or human cells is desirable.

For informal enquiries please contact Professor Dale Wigley d.wigley@imperial.ac.uk.

Closing date: 21/11/2019

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[Post Date: October 29, 2019]


Support Scientist MAX IV MX-group, Lund, Sweden

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Scientist BioMAX (one year)
Lunds universitet, MAX IV, MX group

Lund University was founded in 1666 and is repeatedly ranked among the world’s top 100 universities. The University has 40 000 students and 7 600 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.

MAX IV is a Swedish national large-scale research laboratory hosted by Lund University. It provides scientists from Sweden as well as internationally, with state-of-the-art instrumentation for research in areas such as engineering, physics, structural biology, chemistry and nanotechnology. Fully developed it will receive more than 2 000 scientists annually, conducting ground-breaking experiments in materials and life sciences using the brilliant X-ray light. As a national laboratory, MAX IV is operated in agreement with governmental regulations, and in compliance with major funders such as the Swedish Research Council (VR) and the Wallenberg Foundation. 250 people are currently employed at MAX IV Laboratory, and 16 beamlines are funded. The facility is in a ramp-up phase with 3 beamlines now receiving users and 13 more scheduled to be commissioned and built to receive users within the next few years. The facility is dimensioned for 25-28 beamlines.

The MX-group is looking for a structural biology expert, with a strong interest in operating complex scientific instrumentation of the BioMAX beamline and supporting our international academic and industrial user communities.  

BioMAX is the first operational beamline for macromolecular crystallography at MAX IV, which runs within the MAX IV user program for the last 3 years. The beamline comprises a state-of-the-art installation with high performance x-ray transport and control systems, goniometry, x-ray detectors and a cryogenic sample changer (See also: http://www.maxiv.se/biomax).

The beamline is operated by the international and interdisciplinary BioMAX-team, which is part of the MX-group. Within this group we are also developing jointly a new beamlines project: MicroMAX, a serial crystallography beamline for studying protein dynamics and the FragMAX project, which is aiming to develop and operate a crystallographic fragment screening facility at MAX IV.

This position offers ample possibilities to exploit the beamline capabilities and to contribute to the support of complex research tasks of the growing user communities. Due to the broad spectrum of activities, this position is ideal to develop a related portfolio of expertise and knowledge by the candidate.

Tasks

  • Beam line operation, in close cooperation with the team of scientists and engineers of the MX-group and MAX IV
  • Regular scientific and technical support of external users during their beamtime
  • Regular beamline commissioning tasks
  • Contribute to the on-going in-house research program in regard to fragment-based screening or serial crystallography

 Required Qualifications:

  • PhD or Master university degree in structural biology or natural sciences in subjects of relevance for BioMAX
  • Demonstrated experiences in carrying out structural biology projects using macromolecular crystallography
  • Proven ability to cooperate well within a team
  • Excellent command in written and spoken English
  • A demonstrated ability to work independently
  • Significant experiences in operating complex instrumentation projects at all stages

 Additionally, desirable qualifications:

  • Experience in the use of synchrotron radiation MX-beamlines
  • Experiences in ligand screening, especially fragment screening
  • Experiences in serial crystallography methods
  • Interest and experience in scientific use of techniques of interest for BioMAX (i.e. experiments, data analysis, publication and presentation of results)

MAX IV operates 24/7 and you will be part in on-call service of the MX-group for user support, including weekends and bank holidays in accordance to the working hour regulation.

This is a one year temporary postion.

On call services may apply in the future.

Lund University welcomes applicants with diverse backgrounds and experiences. We regard gender equality and diversity as a strength and an asset. We kindly decline all sales and marketing contacts.


[Post Date: October 29, 2019]


Postdoctoral Researcher University of Oxford

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Description:

We have an open position for a postdoc in structural biology (X-ray crystallography and cryo-EM) in McHugh lab at the WIMM (University of Oxford). The project focus on structural studies of a crucial DNA repair complex involved in ICL repair. We are seeking candidate with strong background in structural biology that will take advantage of the existing setup in our lab to solve the structure of the complex.


[Post Date: October 24, 2019]


Postdoctoral Fellowship in X-ray Crystallography - MD Anderson Cancer Center - Therapeutic Discovery Division

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Description:

A postdoctoral position is currently available in the Structural Chemistry group, part of the Institute for Applied Cancer Science (IACS) within the Therapeutics Discovery Division of MD Anderson Cancer Center. Our mission is to integrate novel biological insights with drug discovery expertise to accelerate the development of innovative, targeted, small-molecule therapeutics for unmet medical needs. Our work is conducted in a team science environment that brings together excellence in both academic and pharmaceutical discovery, as evidenced by recent publications.

We are seeking a highly motivated individual with a strong background in structural biology, including protein expression and purification, protein crystallization, and X-ray crystallography structure determination. Experience with cryo-EM structure determination and/or structure determination of membrane proteins is not required, but would be advantageous. We are seeking only the most dedicated individuals who will join us in our quest to discover, develop and deliver more effective treatments to our patients. This is a unique opportunity to participate in project-driven drug discovery research within a highly respected academic and clinical setting.

Interested individuals should send an introductory email and CV to therapeutics@mdanderson.org 


[Post Date: October 23, 2019]


Postdoc Position in Virus Infection, Plevka group, CEITEC, Czech Republic

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Recruiting two post-doctoral researchers experienced in cryo-EM, cryo-ET, or X-ray crystallography. The projects are focused on characterizing the replication of viruses in situ:

We study the infection of enteroviruses by a combination of FIBM and cryo-ET to determine the mechanism of enterovirus genome delivery into a host cell and changes in intra-cellular organization induced by infection. We complement the whole-cell studies by high-resolution cryo-EM of virus genome release under biologically relevant conditions in vitro.

We employ cryo-ET and light microscopy to characterize the mechanisms that tailed phages, potential phage therapy agents, employ to invade a biofilm and infect bacteria. We use the cryo-ET to determine the functions of bacterial factors in phage genome delivery and characterize phage assembly. We employ time-lapse fluorescence microscopy to establish the relationship between the stage of biofilm development and its susceptibility to phage infection.

Details about my research group can be found here:

http://plevkalab.ceitec.cz

Our in house cryo-EM facility:

https://www.ceitec.eu/cryo-electron-microscopy-and-tomography-core-facility/cf94


[Post Date: October 22, 2019]


Postdoctoral Positions in Engineering Ion Channels and Transporters

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Description:

Two postdoctoral positions are available in the Valiyaveetil group at Oregon Health and Science University in Portland, Oregon. The Valiyaveetil group investigates structure and function of ion channels and transporters using a combination of unnatural amino acid mutagenesis, electrophysiology, structural biology and spectroscopy.  See references [Nat Commun, (2019), 9, 5055; PNAS (2019) 116, 15939-15946] for examples of recent research from the lab.  The group is a part of the Program in Chemical Biology in the Department of Chemical Physiology and Biochemistry.

The positions are suitable for highly motivated candidates with a recent (less than 1 year) Ph.D. in Biochemistry, Biophysics or a related discipline.  The first candidate will investigate ion channels using unnatural amino acid mutagenesis, functional and structural studies.  Candidates for this position should have prior research experience in ion channels and have expertise in carrying out electrophysiological measurements using two-electrode voltage clamp or patch clamp.  The second candidate will investigate transporters using a combination of biochemical, spectroscopic and structural approaches.  Candidates for this position should have prior experience in membrane protein biochemistry and prior expertise in structural approaches such as crystallography or cryo-EM or in fluorescence or EPR spectroscopy will be a plus.  These positions provides the candidates with a unique opportunity to enhance their skill set with the techniques for membrane protein engineering using unnatural amino acid mutagenesis. 

The Valiyaveetil lab is well equipped to carry out structural and functional studies of ion channels and transporters.  OHSU provides an excellent scientific environment.  Portland is consistently rated as one of the most livable cities in the US. 

To apply send CV, a 1-2 page description of graduate research and future research plans along with contact information for three references by email to: valiyave@ohsu.edu 

https://www.ohsu.edu/school-of-medicine/physiology-and-pharmacology/valiyaveetil-lab


[Post Date: October 22, 2019]


Research Technician at La Jolla Institute for Immunology (California, USA)

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Description:

The Ollmann Saphire laboratory at La Jolla Institute for Immunology (LJI) is seeking a technician to work as a part of our team. We are focused on infectious diseases and immune response in general, viral pathogens that cause hemorrhagic fever in particular. The lab has a solid core of structural biologists, virologists and molecular biologists. We are seeking a technician to aid primarily in cloning and protein production, though opportunities abound to learn and contribute to various aspects of our crystallography and tomography efforts, as well as antibody design, antibody discovery and cell culture.

LJI is located in beautiful San Deigo, CA. You can find out more about LJI, its mission, breadth of research and approach to human health, here: https://www.youtube.com/watch?v=PbV1CjlriC8#action=share

You can find out more about the Ollmann Saphire laboratory here https://www.lji.org/faculty-research/labs/saphire/#overview. Please contact Dr. Erica Ollmann Saphire directly at erica@lji.org with leads or inquiries about this position.


[Post Date: October 21, 2019]


Scientist-I (Structural Biology) at Frederick National Laboratory for Cancer Research

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The Frederick National Laboratory for Cancer Research is looking for a Scientist with experience in protein chemistry and structural biology. The candidate will join the structural biology group within the NCI RAS Initiative program and work on the protein-small molecule complexes.  For detailed information and to apply for this position, please use this link:  https://leidosbiomed.csod.com/ats/careersite/jobdetails.aspx?site=4&c=leidosbiomed&id=765 


[Post Date: October 17, 2019]


Postdoctoral position in Xing Lab at UW-Madison

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Description:

A postdoctoral position on structural biology is available to investigate the mechanisms and functions of phosphatase signaling complexes and their disease mutations in cancer and intellectual disability. We combine cryo-EM, x-ray crystallography, cell biology, system biology, biochemistry, computational biology, and bioinformatics to gain critical knowledge on complex phosphatase signaling network dictated by both allosteric structured cores and versatile signaling motifs. The research is performed in a highly multidisciplinary setting with basic scientists with expertise on Cryo-EM, biochemistry, cell biology, bioinformatics and chemical biology. We are well equipped for multidisciplinary research, such as powerful GPU computer, liquid handling crystallization robot, and live cell imaging system. In addition, our lab is conveniently located near multiple shared facilities. Our research is built on collaborations with more than 10 groups from US and Europe as well as dynamic collaborations on campus in both basic and clinical research. UW-Madison has highly collaborative research environment that easily establish novel collaborations.


We are seeking productive, and motivated individuals with excellent organizational, interpersonal, and communication skills. We expect our candidates have strong expertise in either cryo-EM or x-ray crystallography, and protein biochemistry. We also expect our candidates feel comfortable to apply system biology and in-house bioinformatic tools and work both independently and by collaboration toward personalized medicine for phosphatase diseases.

The starting salary for promising candidate will be $48,000 or above.

Review of applications will begin immediately and continue until the position is filled. To apply: Please send a cover letter, CV and the names and contact information for three references to Dr. Yongna Xing via email: xing@oncology.wisc.edu.

Under-represented minorities are encouraged to apply.

https://mcardle.wisc.edu/who-we-are/mcardle-faculty/yongna-xing-phd


[Post Date: October 14, 2019]


Two tenure-track faculty openings at Univ. of Missouri Biochemistry

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The University of Missouri (MU) invites applications for two tenure-track faculty positions in the Department of Biochemistry, which is a joint academic division within the College of Agriculture, Food and Natural Resources (CAFNR) and the School of Medicine (SOM).  These faculty positions will be affiliated formally with either CAFNR and/or SOM, and responsibilities will include contributions to undergraduate, graduate and medical education. This is the first in a series of recruitments. We seek applications in our areas of interest including plant biochemistry, gene/genome regulation, gene delivery and transgenic technology, synthetic biology, medicinal biochemistry, structural biology and imaging, including development of new molecular markers and reporters. Related areas of research will also be considered.  Review of applications will begin November 15, 2019

 

 


[Post Date: October 14, 2019]


Postdoc University of Birmingham

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Description:

We are interested in recruiting an enthusiastic and talented individual at the post-doctoral level with experience in structural biology and biochemistry to join a team investigating how complex macromolecular interactions in the human DNA-damage response (DDR) are regulated by post-translational modifications such as phosphorylation and ubiquitination. A range of projects are available in the lab but of particular interest are recruitment mechanisms that localise DDR complexes to chromatin through post-translational modifications of histones and their interacting proteins. The research will be carried out in the laboratory of Steve Smerdon (https://www.birmingham.ac.uk/staff/profiles/cancer-genomic/smerdon-steve.aspx) at the Institute of Cancer and Genomic Sciences (ICGS) located within the University of Birmingham Medical School in the UK. Experimental approaches will be highly multi-disciplinary with a focus on structural characterisation using X-ray crystallography and EM/cryo-EM, and the work will benefit from close interactions with a network of collaborators worldwide and a cluster of world-class laboratories within the ICGS interested in DDR biology.

References to some of our earlier work: Kyrieleis, O.J.P. et al. (2016) Cell Reports, 17, 3099 / Hořejší, Z. et al. (2014) Cell Reports, 7, 19 / Rock, J.R. et al. (2013) Science 340, 871 / Lloyd, J. et al., (2009) Cell 139, 100 / Stucki, M. et al. (2005) Cell 123, 1213 / Clapperton, J.A. (2004) Nat. Struct. Mol. Biol. 11, 512 / Elia, E.H.A. et al. (2003) Cell 115, 83.

The position is a full-time post-doctoral appointment with an initial duration of 36 months and salary commensurate with age and experience. Post is available immediately but start date is negotiable.

Further details about applying, Ts&Cs etc can be found here at:

https://bham.taleo.net/careersection/external/jobdetail.ftl?job=190002U1&tz=GMT%2B01%3A00&tzname=Europe%2FLondon


[Post Date: October 14, 2019]


Postdoc Institute of Molecular and Cell Biology, A*STAR, Singapore

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Description:

We are seeking an enthusiastic and self-motivated postdoctoral research fellow to study proteins involved in maintaining genome stability and the Hippo signaling pathway. We take a combinatorial approach of molecular biology, biochemical and biophysical methods, and structural biology (macromolecular crystallography and electron cryomicroscopy). ­Significant aspects of our projects have translational potential. The candidate is expected to be involved in the development of small molecules/peptides for cancer therapeutics.

Singapore is an excellent environment to do research with many research groups close by in Biopolis [https://www.a-star.edu.sg/imcb]. A*STAR offers highly competitive salaries with benefits including housing allowance and 1-3 months performance bonus.

Requirements:

  • PhD in biochemistry, biophysics, molecular & cell biology or in  medicinal chemistry
  • Practical experiences in structural biology (Electron Cryomicroscopy and/or X-ray crystallography) or in medicinal chemistry
  • Good publication record
  • Competent in scientific writing

Interested applicants should send a CV and three confidential letters of reference to: Prof. Haiwei Song (Email: haiwei@imcb.a-star.edu.sg), Institute of Molecular and Cell Biology, A*STAR, Singapore.


[Post Date: October 14, 2019]


Postdoctoral position for XFEL crystallography/spectroscopy at Berkeley Lab

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Description:

We are looking for a postdoctoral fellow to study metalloenzymes using X-ray crystallography and spectroscopy at X-ray free electron lasers. The fellow will work in the Kern/Yachandra/Yano group (http://www2.lbl.gov/vkyachan/ and http://biosciences.lbl.gov/profiles/jan-florian-kern/) at Berkeley Lab’s Molecular Biophysics & Integrated Bioimaging Division. We have been conducting a number of XFEL experiments on several different systems and recent publications include:

Chatterjee et al J Synchr Rad 2019 https://onlinelibrary.wiley.com/doi/abs/10.1107/S1600577519007550
Kern et al, Nature 2018 https://www.nature.com/articles/s41586-018-0681-2

Fuller et al, Nature Methods 2017 http://www.nature.com/nmeth/journal/v14/n4/abs/nmeth.4195.html

Kubin et al Structural Dynamics 2017 https://aca.scitation.org/doi/10.1063/1.4986627
Young et al Nature 2016 https://www.nature.com/nature/journal/v540/n7633/full/nature20161.html

Ideally the candidate should have a good background in one or more of the following fields:
- Macromolecular crystallography
- X-ray spectroscopy of dilute transition metal systems/biological systems.
- Designing of experimental setups for use at synchrotron/X-ray free laser facilities.

Details of the position and instructions how to apply can be found here:
https://lbl.referrals.selectminds.com/jobs/xfel-postdoc-for-crystallography-spectroscopy-2214


[Post Date: October 14, 2019]


Group Leader Opening at the Novo Nordisk Foundation Center for Protein Research

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Description:

Junior Group Leader Opening at the Novo Nordisk Foundation Center for Protein Research

The Novo Nordisk Foundation Center for Protein Research (CPR) is committed to attract and nurture the development of young talented independent investigators in our unique environment. With this call we wish to recruit a Group Leader to become part of our Protein Structure and Function Program.

The Novo Nordisk Foundation Center for Protein Research

The Novo Nordisk Foundation Center for Protein Research (https://www.cpr.ku.dk) was established in 2007 at the Faculty of Health and Medical Sciences, University of Copenhagen, to promote basic and applied research. Copenhagen is a family friendly but at the same time lively city flooded with cultural events during the year, which is ranked among the best cites to live in the world.

CPR spans broad areas of protein research, ranging from structural and mechanistic understanding of protein complexes and protein pathways. The Center is structured into five complementary research programs: Proteomics, Protein Structure and Function, Protein Signaling, Disease Systems Biology and Protein Memory (starting in 2020), each of which is supported by dedicated technology platforms.

Protein Structure and Function Program

The Protein Structure and Function Program is a founding member of the Integrative Structural Biology Cluster (ISBUC) at the University of Copenhagen (https://isbuc.ku.dk/), and it currently consists of two research groups led by Professor Guillermo Montoya and Associate Professor Nicholas Taylor. The program also coordinates the Center´s protein production, molecular biophysics and crystallization platforms and the University of Copenhagen node of the national cryoEM facility (https://krios-denmark.ku.dk/), which is equipped with a Titan Krios and a Glacios, both equipped with Falcon 3EC direct electron detectors. Large computer power is available through our partnership with the Danish Supercomputer for Life Sciences (http://www.computerome.dtu.dk/). In addition, the Copenhagen area provides easy access to the synchrotrons in Hamburg (DESY) and Lund (MAX-IV) as well as the European XFEL (Hamburg).

Job description and responsibilities

We are looking for strong candidates that would develop and lead an independent, innovative research group investigating game changer questions in biology at a molecular level. We seek for applicants in the area of integrative structural biology using and/or combining cryo-electron microscopy (including cryo-electron tomography), crystallography and biophysical approaches towards the mechanistic understanding of cellular processes. The ideal candidate should be complementary to the current interests and analytical expertise in the Protein Structure and Function Program and with a high potential to integrate within the other CPR programs through interdisciplinary projects.


[Post Date: October 11, 2019]


Structural Biology Scientist position at Foghorn Therapeutics in Cambridge, MA, USA

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Description:

Foghorn Therapeutics has an exciting job opportunity for an early career Scientist in Structural Biology. Please apply directly to the official posting:

https://foghorntherapeutics.applytojob.com/apply/Ywz0Aq2yt3/Scientist-Structural-Biology?referrer=201910071330233OATDSO00TJPSK0N

POSITION SUMMARY

TITLE:                  Scientist, Structural Biology

REPORTS TO:     Principal Scientist, Drug Discovery

LOCATION:        Cambridge, MA

COMPANY DESCRIPTION

Through its Gene Traffic Control Product Platform, Foghorn® Therapeutics is discovering and developing an unprecedented class of medicines targeting diseases with genetically determined dependencies in the chromatin regulatory system. The Company, currently pre-clinical stage, is rapidly advancing over 10 programs across a wide range of cancers and is beginning to explore other diseases.

The chromatin regulatory system orchestrates the movement of molecules that turn genes on and off. Disease dependencies associated with chromatin dysregulation are estimated to impact approximately 2.5 million cancer patients in G7 countries and chromatin dysregulation is further implicated in neurological, autoimmune, and other serious diseases. Foghorn’s proprietary Gene Traffic Control Product Platform is based on the Company’s unique insights into the chromatin regulatory system and enables highly scalable drug discovery and development efforts.

Foghorn, a Flagship Pioneering® company, was founded in 2016 by Cigall Kadoch, Ph.D., Gerald Crabtree, M.D., and Doug Cole, M.D., of Flagship Pioneering. Learn more about Foghorn at www.foghorntx.com.  

POSITION DESCRIPTION
We are seeking a highly skilled and motivated structural biologist to become an integral member of the Foghorn team. This person will contribute to our goal of developing transformative therapeutics by planning and carrying out structural characterization of crucial drug targets. The main focus of this role will be protein crystallography but will require a willingness to find new ways to think about scientific challenges. We need someone who is passionate, driven, and ambitious to help us achieve our goal of improving patients’ lives. 


Responsibilities include:

  • Collaborating with colleagues in biochemistry, biology, and chemistry to develop structural biology strategy.
  • Designing biophysics-grade protein constructs and assisting in the optimization of purification protocols.
  • Crystallization, X-ray structure determination, and analysis of important drug targets.
  • Providing regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with medicinal and computational chemists.
  • Participating in the management of collaborations with contract research organizations (CROs) and academic partners.

QUALIFICATIONS

  • PhD in Structural Biology, Biophysics, Biochemistry or a closely related field, with a background in chemistry.
  • Demonstrated competency in protein construct design and expression and purification strategies using bacterial, insect, and mammalian hosts. Experience with multi-protein complexes is a plus. 
  • Deep expertise in protein crystallization and X-ray structure determination of protein-ligand complexes.
  • Extensive knowledge of protein structure and function, with the ability to articulately communicate structural information to a broad audience.
  • Experience with other structural techniques (e.g. electron microscopy, small-angle X-ray scattering) is strongly preferred.
  • Excellent time management and communication skills. 
  • Ability to work in a fast-paced, team-driven environment, with a collaborative and proactive attitude.


[Post Date: October 9, 2019]


Postdoctoral Position in Structural Biology/Molecular Biology at the University of Nebraska-Lincoln, Lincoln NE, USA

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Description:

One postdoctoral research associate position is immediately available in Prof. Limei Zhang’s group at the Dept. of Biochemistry and the Redox Biology Center, University of Nebraska-Lincoln, USA (http://biochem.unl.edu). The research in the Zhang Laboratory focuses on the structure-mechanism relationship of proteins in redox biology, stress response and antibiotic resistance.

The successful candidates are expected to have the following requirements:

  • Have a recent PhD degree (or expected soon) in molecular biology, biochemistry, microbiology or similar field with track record in conducting high quality research.
  • Expertise in either structural biology or advanced molecular biology is highly desired
  • With excellent communication and collaborative skills

The position offers competitive salary and benefits package. 

The University of Nebraska-Lincoln is located in a vibrant and safe city offering outstanding and affordable quality of life, and numerous multi-cultural and entertainment benefits. The Redox Biology Center is organized as a broad-based interdisciplinary and multi-institutional entity involving researchers from the University of Nebraska-Lincoln and the University of Nebraska Medical Center in Omaha, and offers supportive and collaborative international environment as well as access to cutting edge proteomics, metabolomics, crystallography, and NMR facilities.

To apply for the position, please submit a letter of interest with a short summary of past research experience; your curriculum vitae, and contact information for three professional references, including phone numbers and emails to limei.zhang@unl.edu

As an EO/AA employer, qualified applicants are considered for employment without regard to race, color, ethnicity, national origin, sex, pregnancy, sexual orientation, gender identity, religion, disability, age, genetic information, veteran status, marital status, and/or political affiliation. See http://www.unl.edu/equity/notice-nondiscrimination.


[Post Date: October 9, 2019]


Postdoc University of Wuerzburg

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Description:

The Thorn Laboratory the Rudolf Virchow Center at the University of Wuerzburg  develops new methods for macromolecular X-ray crystallography and Cryo-EM. In these exciting projects you will improve how well we understand, measure and model macromolecular crystal structures using practical experiments and big data analyses. We are looking for candidates with skills in data analysis and programming. Any previous experiences in crystallography, molecular biology, machine learning, image or statistical analysis are also a bonus. You should be a good communicator. For the PhD project, we offer a 36-month full- or part-time position, embedded in the Würzburg Graduate School for Life Sciences (GSLS); for the postdoctoral position, we offer a 30-month full- or part-time position with a competitive salary as well as career and family support. Women are particularly encouraged to apply.

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[Post Date: October 7, 2019]


Assistant Project Scientist & Postdoc UC Davis

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Description:

I am recruiting for two positions in my laboratory (http://microtubule.mcb.ucdavis.edu) at the University of California, Davis.  Our Laboratory is focused on structural mechanisms of molecular machines that regulate tubulin heterodimer biogenesis, dynamic microtubule polymerization, and mechanisms of mitotic kinesin motor proteins. There are well-developed projects in our laboratory to elucidate mechanisms of these multi-subunit complexes using the biochemical reconstitution, cryo-EM and / or x-ray crystallography and validate these mechanisms using single molecule fluorescence reconstitution with microtubules.  

Our laboratory has extensive setups for protein production, biochemical characterization, x-ray crystallography, full access to a cryo-EM sample preparation setup, a semi-automated side-entry JEOL 2100F for sample screening, and an automated 200 KV Glacios equipped with an autoloader and a Gatan K3 detector.  UC-Davis is a member of the Bay Area Cryo-EM consortium with monthly access to Titan Krios microscopes for high-resolution data collection.  for example multi-disciplinary studies: https://www.ncbi.nlm.nih.gov/pubmed/?term=Al-bassam+J, https://www.biorxiv.org/content/10.1101/713909v2

Assistant Project Scientist:
The suitable candidates should have a PhD in chemistry, biochemistry or biophysics and has successfully completed postdoctoral training in either single particle cryo-EM and/or x-ray crystallography with extensive expertise in molecular cloning, recombinant protein production and purification using bacteria, and insect or mammalian expression systems:  https://recruit.ucdavis.edu/JPF03202

Postdoctoral fellow:
The suitable candidates should have a PhD in chemistry, biochemistry or biophysics with expertise in either single particle cryo-EM and/or x-ray crystallography, molecular cloning, recombinant protein production and purification using bacteria, and insect or mammalian expression systems: https://recruit.ucdavis.edu/JPF03203

Please send any informal inquiries to jawdat@ucdavis.edu. Please include a cover letter, CV, statement of research accomplishments, and two to three reference letters.


[Post Date: October 7, 2019]