Description:

Institut de Biologie Structurale (Universite de Grenoble Alpes–CNRS–CEA)
Workplace Grenoble - Auvergne-Rhone-Alpes - France
Topic title PhD position – Developing a novel class of antifungal drugs against a multidrug-resistant fungal pathogen
Scientific expertise
Biology
Chemistry
Health, human and veterinary medicine

Keywords Drug discovery, Structural biology, Biochemistry, Biophysics, Infectious disease, Epigenetics, X-ray crystallography, Fungal pathogens, Antifungal, Candida

Invasive fungal infections cause over 2.5 million deaths per year and represent an escalating global health threat, creating an urgent need for new antifungal drugs. The recent emergence of Candida auris, a multidrug-resistant fungal "superbug" responsible for severe hospital outbreaks and high mortality worldwide, is particularly alarming. BET bromodomains are chromatin-binding epigenetic readers that recognize acetylated histones and are essential for fungal viability and virulence. This PhD project aims to establish a novel antifungal strategy by developing small-molecule inhibitors that target BET bromodomains, with a particular focus on Candida auris.

Building on our previous proof-of-concept studies that identified BET bromodomains as promising antifungal targets, we have established molecular and cellular tools to accelerate the discovery of antifungal BET inhibitors [refs.1,2]. These include FRET-based assays for compound screening, humanized Candida strains for on-target validation, and NanoBiT assays to monitor BET bromodomain inhibition directly in fungal cells. This project represents the translational next phase of our research program. It will exploit an AI-guided drug discovery approach called V-SYNTHES (Virtual Synthesis Screening), a structure-based method that enables rapid exploration of ultra-large chemical spaces [ref.3], to develop potent BET inhibitors targeting Candida auris. Inhibitors will be profiled using biophysical, biochemical and cellular assays and structurally characterized in complex with their bromodomain targets. Their activity will then be evaluated for on-target engagement, antifungal efficacy in animal infection models, and resistance development.

The PhD student will play a central role in this research and will be responsible for protein production, biophysical characterization, structure determination of protein-ligand complexes by X-ray crystallography, cellular assays in Candida species, and the assessment of antifungal activity and resistance. This project will be carried out at the Institute of Structural Biology (IBS) in Grenoble, France, in collaboration with experts in medicinal chemistry, medical mycology and fungal epigenetics at the University of Southern California, Grenoble University Hospital and the Institute of Advanced Biosciences (IAB, Grenoble). The project offers an ideal framework for developing expertise in translational research at the interface of structural biology, drug discovery, fungal epigenetics and infectious disease in a highly collaborative environment.

References:
1. Mietton et al., 2017. Nature Communications 8:15482. https://doi.org/10.1038/ncomms15482
2. Wei et al., 2025. Advanced Science 16:e2404260. https://doi.org/10.1002/advs.202404260
3. Sadybekov et al., 2022 Nature 601:452. https://doi.org/10.1038/s41586-021-04220-9

More information:
https://www.ibs.fr/en/research/assembly-dynamics-and-reactivity/epigenetics-and-molecular-pathways-group-c-petosa/petosa-team/epigenetic-targets-in-pathogenic-fungi/

Starting date
2026-10-01

Funding category
Public funding alone (i.e. government, region, European, international organization research grant)

Funding further details
36-month PhD contract (CFR) fully funded by the CEA

Presentation of host institution and host laboratory
Institut de Biologie Structurale (Université de Grenoble Alpes–CNRS–CEA) Research at the Institute of Structural Biology (IBS) aims to understand the molecular mechanisms underlying cellular processes and human disease. Its 300 researchers and staff (including 70 PhD students) are organized into 20 groups that perform interdisciplinary research at the interface of biology, physics and chemistry.

Located on the European Photon and Neutron (EPN) Campus in Grenoble, France (http://www.epn-campus.eu), the IBS is a member of the Partnership for Structural Biology (http://www.psb-grenoble.eu), which provides cutting edge facilities for innovative research in the biomolecular sciences, including on-site access to synchrotron and cryo-EM facilities.

The IBS is affiliated with the Doctoral School of Chemistry and Life Sciences at the University of Grenoble Alpes (https://edcsv.univ-grenoble-alpes.fr/edcsv), which ranks among the top 6-8 universities in France and the top 150-200 in the world, according to the Shanghai academic ranking of world universities.

Host lab home page:
https://www.ibs.fr/en/research/assembly-dynamics-and-reactivity/epigenetics-and-molecular-pathways-group-c-petosa/

Living in Grenoble:
http://www.ibs.fr/jobs/about-grenoble/

Website :
http://www.ibs.fr

PhD title
Ph.D.

Country where you obtained your PhD
France

Institution awarding doctoral degree
UNIVERSITE GRENOBLE ALPES

Graduate school
Chimie et sciences du vivant

Candidate's profile
Highly motivated candidates with a background in chemistry, biochemistry, biology or life sciences and a strong interest in structural biology and drug discovery are invited to apply. Candidates should have a Master’s Degree (or equivalent) or should expect to receive it in the near future. Previous laboratory experience in protein expression and purification, biochemical or biophysical assays, or structural biology approaches is an advantage. Basic programming or data analysis skills are also an asset.

Application deadline
2026-05-17

[Post Date: April 15, 2026]

Description:

Location: Canterbury
Salary: £39,906 to £44,746 per annum, Grade 7
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 10th April 2026
Closes: 17th May 2026
Job Ref: SNS-065-26-R

We are seeking a motivated Research Associate to work within the PAL laboratory within the School of Biosciences at the University of Kent.

This role is funded by the British Heart Foundation for investigating the assembly of multi-protein complexes in congenital heart defects. The successful candidate will work on a cutting-edge experimental research project involving assemblies of multi-protein complexes. The project combines biochemistry, biophysics, and structural biology. The structural biology part of the project will involve multi-protein complex assemblies, single-particle cryo-electron microscopy (cryo-EM) and X-ray crystallography. The role will also include developing research objectives, conducting research, writing research work for publication, and liaising with national and international collaborators. There will also be an opportunity to learn cell biology to complement the structural biology work.

For informal enquiries, contact Mohinder Pal, Lecturer and Group leader, School of Biosciences (M.Pal@kent.ac.uk)

As a Research Associate you can expect to be involved in:
• Contributing to the design and execution of research projects, ensuring alignment with institutional and departmental goals. 
• Developing research proposals and objectives, collaborating with colleagues to enhance project outcomes. 
• Conducting individual and collaborative research, gathering and analysing data to derive meaningful conclusions. 
• Organising, storing and writing up results and report regularly to the research group, partners and other stakeholders.

What will you bring to the role?
• PhD in Biochemistry, structural biology or related relevant discipline or equivalent (or to be in the final stages of obtaining such a qualification and able to evidence that the PhD viva will be held as soon as possible) 
• Proven experience in conducting research projects, including data collection and analysis 
• Specialist expertise in or theoretical knowledge in molecular biology, biochemistry, especially protein expression, purification

What we can offer in return:

As a member of our team, you can expect a friendly, open and collaborative working environment and support in your development and wellbeing. You'll enjoy a range of great staff benefits including:
• Hybrid working options allowing a flexible blend of office and home working (to be agreed in line with business needs) 
• 43 days' leave per year (personal leave, bank holidays and additional days allocated for the Christmas period, pro rata for part-time staff) 
• Excellent pension scheme with generous employer contributions 
• Corporate employee-funded healthcare plan, in partnership with Benenden Health

For more information about what you can look forward to if you join us, visit our dedicated webpage: Working at Kent

We are ambitious for our people, our communities and the region we serve – join us in making the world a better place. Visit our website for more on who we are: http://www.kent.ac.uk/about/

Please see the links below to view the full job description and to apply for this post. For further information regarding the application process, please contact peopleserviceshr@kent.ac.uk quoting reference number SNS-065-26-R.

We particularly welcome applications from female candidates as they are under-represented at this level in this area

[Post Date: April 14, 2026]

Description:

Applications are sought for a committed Post-doctoral Research Fellow to work with Dr Rafael Guimaraes da Silva conducting research for a Leverhulme Trust Research Grant funded project to dissect catalysis and allostery in a gut microbiome ATP phosphoribosyltransferase enzyme. The primary duties will be to uncover the catalytic and allosteric mechanisms via protein crystallography and enzymology.

The successful applicant will have (or be near to completion of) a PhD in Biochemistry or Structural Biology with expertise in X-ray crystallography and enzymology.

The post is available for 36 months starting 1st July 2026 or as soon as possible thereafter.

Further information and informal enquiries may be directed to Dr Rafael Guimaraes da Silva at rgds@st-andrews.ac.uk

Benefits:
• Financial contribution to relocation (subject to eligibility) 
• Membership of the USS Pension Scheme with generous employer contributions of 14.5% 
• A hybrid working environment, including partial homeworking where appropriate and a range of family friendly policies, supporting work-life balance 
• Staff discount scheme for local and national goods and services 
• Free staff parking, employee Carshare and Cycle to Work Schemes and subsidised local bus travel 
• Subsidised sports membership, reduced tuition fees on degree programmes for staff, access to training and development opportunities including LinkedIn Learning, access to library facilities, salary sacrifice scheme 
• 34 Days Annual Leave plus 5 Public Holidays.

At St Andrews, equality, diversity, and inclusion are central to who we are and form a core pillar of our University Strategy. We are committed to creating a fair, inclusive and supportive workplace, reflected in our participation in national diversity charters and awards, including Athena Swan, Carer Positive and the Race Equality Charter.

We particularly welcome applications from people from Black, Asian, minority ethnic and minority religions backgrounds and from LGBTQ+ and disabled people.

Closing date: 17 April 2026
Interview date: 11 May 2026
Job Description: AR3262RS FPs.pdf
Ref no: AR3262RS

School of Biology
Salary: Grade 6 / £38,784 pa
Start date: 1 July 2026
Full time
Fixed term: 36 months

[Post Date: April 6, 2026]

Description:

Position Overview
The laboratory of Dr. Jiaoyang Jiang at the University of Wisconsin-Madison (USA) is seeking a fully funded Postdoctoral Research Associate in Structural Biology. The postdoc researcher will lead structural studies using cryo-EM, X-ray crystallography, and complementary integrative approaches to understand protein complexes involved in glycosylation-associated biological and disease processes. This position offers access to state-of-the-art facilities and close collaborations with chemical and cell biologists to connect structural insights to functional mechanisms and drug discovery opportunities.

Jiang Lab website: https://pharmacy.wisc.edu/faculty/jiang-research-group/

Preferred Qualifications
· PhD in structural biology, biochemistry, biophysics, or related fields with 0-1 year of postdoctoral experience.
· Strong motivation and research experience in protein purification and at least one structural technique (e.g., cryo-EM, X-ray crystallography).
· At least one first-author research publication in a peer-reviewed, internationally recognized journal.
· Excellent communication and interpersonal skills in English.
· Ability to work independently and thrive in a collaborative, interdisciplinary environment.

Application Instructions
Applications will be reviewed on a rolling basis. To apply, email the following materials to jiaoyang.jiang@wisc.edu
· CV
· Cover letter summarizing research experience and interests
· Contact information for three references

[Post Date: April 6, 2026]

Description:

Columbia University in the City of New York: Arts and Sciences Core - Academic: Department of Biological Sciences
Location: 01
Open Date: Mar 25, 2026
Salary Range or Pay Grade: $65,000-$65,000

Description
The Department of Biological Sciences at Columbia University in the City of New York invites applications for a Staff Associate II. The successful candidate will lead and contribute to projects aimed at advancing and sustaining X3DNA-DSSR, an NIH-funded (R24GM153869) NIGMS National Resource for structural bioinformatics. Under the supervision of the PI, the SAII’s responsibilities include:
· Modernizing and maintaining the 3DNA/DSSR software suite and web interfaces.
· Enhancing software usability, comprehensive documentation, and research reproducibility.
· Engaging with and supporting an active global user community.
· Developing automated pipelines and performing sophisticated structural data analysis.
· Collaborating with experimental and computational researchers to drive scientific discovery.

Specific Duties:
1. 30% – Structural Data Analysis: Perform community-driven analysis and standardization of macromolecular structures (PDBx/mmCIF) to validate new DSSR features and contribute to peer-reviewed publications.
2. 25% – User Community Engagement: Lead the development of technical documentation, tutorials, and instructional videos while providing direct technical support to the global X3DNA-DSSR user base.
3. 20% – Software Engineering: Maintain and optimize the core DSSR engine and backend infrastructure, including the management of relational databases and the REST API to ensure reliable resource access.
4. 15% – Develop New Code to Automate Algorithm Deployment: Write and deploy automation scripts to streamline high-throughput data processing and ensure stable software deployment across macOS and Linux environments.
5. 10% – Interpreting and Visualizing Research Results: Maintain and provide minor updates to existing web-based visualization tools for 1D, 2D, and 3D nucleic acid representations to ensure continued compatibility for users.

Application materials received by April 15, 2026 will receive full consideration. Application screening will begin immediately and will continue until the position is filled.

Qualifications
Bachelor’s in computational biology, bioinformatics, computer science, or a related field.

Candidates also need the following experience and skills:
· Strong programming skills (Python/Ruby/bash, R, Java, C/C++ etc.)
· Experience working in Linux/Unix/macOS environments
· Familiarity with version control systems (e.g., Git)
· Interest in scientific software development and community engagement

Application Instructions
All applications must be made through Columbia University’s Academic Search and Recruiting (ASR) system. Please upload the following required material: curriculum vitae.

Application Process
This institution is using Interfolio's Faculty Search to conduct this search. Applicants to this position receive a free Dossier account and can send all application materials, including confidential letters of recommendation, free of charge.

Apply Now

Equal Employment Opportunity Statement
Columbia University is an Equal Opportunity Employer / Disability / Veteran

Pay Transparency Disclosure
The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University’s good faith and reasonable estimate of the range of possible compensation at the time of posting.

[Post Date: April 6, 2026]

Description:

Category
Biology, biophysics and biochemistry

Contract
Fixed-term contract

Job title
Researcher in protein biochemistry H/F H/F

Socio-professional category
Executive

Contract duration (months)
24

Job description
Are you passionate about the enzymatic reactions of anaerobic microbes and keen to contribute to excellence in scientific research? Join us as a post-doc/researcher on a two-year fixed-term contract, with a possible extension, and be part of the IBS/IRIG Institute!

The position is available to investigate the enzymatic chemistry orchestrated in the microbial anaerobic carbon cycling. The offer is part of the ERC Project “EnLightEn,” which is devoted to understanding the molecular basis of methanogenesis and methanotrophy in non-isolated anaerobic archaea. The position will be hosted in the newly established Microbial Metabolism team, with a preferred starting date of late summer 2026.

Your tasks will include
Preparing microbial biomass (microbial enrichments cultured in flasks or bioreactors, as well as environmental samples),
Extract the proteins involved in catabolic processes and purify them using our oxygen-free process,
Characterise the proteins using biochemical, biophysical and structural tools,
Analyse the data obtained to elucidate the reaction mechanisms,
Present these findings in the form of scientific articles.

This unconventional approach, which circumvents the barrier posed by microbial isolation, enables us to understand the molecular mechanisms of native enzymes involved in the conversion of carbon-based molecules, with potential applications in industrial chemistry. EnLightEn will open up a new field of research to characterise functional dark matter, which can then be applied to other metabolic processes and offer an unprecedented insight into the molecular tricks employed by the microbial world.

Applicant Profile
The ideal postdoc candidate must hold a PhD in protein biochemistry and have a solid background in structural biology, including the purification of native enzymes, their crystallization, X-ray crystallographic data collection, structural analyses, and enzyme functional assay. Candidates with experience in anaerobic handling, from microbial production to the crystallization/characterization of O2-sensitive proteins, are strongly encouraged to apply and will be treated as a priority. Cultivation of anaerobic microbes and skills in cryo-electron microscopy are welcomed but not mandatory. Interest in metalloenzymes, extremozymes, and the reaction mechanisms involved in microbial metabolic pathways is fundamental to developing at maximum potential in the laboratory.

You will need to demonstrate an open mind and a high degree of scientific rigour. You must be fluent in English, which will enable you to communicate effectively with the team and write scientific articles

Why join us? ….
By joining the Grenoble Interdisciplinary Institute, you’ll be part of a dynamic and innovative research environment where you’ll have the opportunity to learn, grow and play a key role within a centre of excellence.

…AND THAT’S NOT ALL!

You may be interested in the benefits that come alongside your main role:
A cutting-edge research ecosystem dedicated to topics of significant societal importance.
Training to enhance your skills and boost your career. A staff committee offering a wealth of social, cultural and sporting benefits. Practical benefits: staff canteen/meal vouchers, 85% of transport costs covered, and much more. An exceptional living environment in Grenoble, nestled in the mountains, offering a unique balance between city life and nature. Want to be part of the adventure? Apply now and put your energy to work for research and innovation!

In line with the CEA’s commitments to the integration of people with disabilities, this role is open to everyone. The CEA offers adjustments and/or organisational arrangements to facilitate the inclusion of disabled workers

Position location Site
Grenoble

Job location
France, Auvergne-Rhone-Alpes, Isere (38)

Location
Grenoble

Candidate criteria
Languages
English (Fluent)
French (Intermediate)

Recommended training
PhD in protein biochemistry

Requester
Position start date
01/06/2026

[Post Date: March 20, 2026]

Description:

[Post Date: March 20, 2026]

Description:

Opening of a fully funded 3-year PhD position in membrane biophysics in the Membrane Transport Laboratory at the Department of Molecular Medicine, University of Pavia (Italy).

This position offers an excellent opportunity to contribute to cutting-edge research in the structural biology of ion channels and transporters. Our laboratory focuses on the biophysical mechanisms underlying ion channel and transporter function, with particular attention to proteins involved in pathological conditions.

More information about the laboratory, including a selection of recent publications, can be found here:
https://medicinamolecolare.dip.unipv.it/en/research/research-teams-and-topics/immunology-and-general-pathology/ion-channels-and-transporters

The project will focus on the biophysical validation and structural characterisation of human membrane transporters. The selected candidate will employ a broad range of methodologies, including molecular biology, biochemistry, electrophysiology, ligand-binding assays, and cell biology.

Our laboratory is equipped with state-of-the-art facilities for membrane protein expression, purification, and crystallisation. In addition, we have continuous access to the campus core facility for cryo-EM, which includes a complete pipeline for grid preparation and data collection on a Glacios 200 kV cryo-electron microscope.

Desired profile

- MSc (or equivalent) in Biophysics, Physics, Chemical Physics, Biochemistry, or a related field
- Experience in protein expression and purification using different host systems
- Familiarity with computational structural biology tools (e.g. Python, CCP4, CryoSPARC) is a plus
- Experience with membrane proteins is advantageous
- Strong written and oral communication skills in English
- Ability to work independently and collaboratively
- Scientific curiosity, creativity, and team spirit

Application procedure and contact

Applications and informal inquiries should be sent by email to:

Prof. Marco Lolicato
marcogaetano.lolicato@unipv.it

Please submit the following documents as separate PDFs:

- Cover letter outlining motivation and relevant experience (max. 1 page)
- Curriculum vitae detailing academic and professional background
- Copies of MSc degree and transcripts
- Up to two letters of recommendation (max. 1 page each)

Please indicate in the subject line:
“UniPV PhD – [Your Name]”

Shortlisted candidates will be invited for a remote interview.

[Post Date: March 17, 2026]

Description:

Faculty of Health and Medical Sciences
University of Copenhagen

The University seeks to appoint one or two visionary and team-oriented tenure track assistant professors to the Department of Drug Design and Pharmacology to commence September 1st, 2026, or as soon as possible thereafter.

Department of Drug Design and Pharmacology is committed to advancing human health through discovery, design, and evaluation of safe and effective medical treatments. To achieve this, we work in a dynamic and committed academic community, that bridges health science and life science in a translational and innovative approach from molecule to patient. We value interdisciplinary research and education, development of individual competences, and finding solutions to todays and tomorrows challenges in society. The department furthermore prioritizes sustainability in all aspects of research and education.

The department is organized in six research sections and furthermore houses Center for Pharmaceutical Data Science Education and Center for Protein Design. Further information on the Department can be found at: https://drug.ku.dk/

We welcome applications from ambitious and talented early-career researchers seeking to build a strong profile within drug-related research. The section Qualifications of the applicant below outlines six overall assessment criteria for the position. Applicants with expertise spanning all areas of drug research are encouraged to apply; however, preference will be given to candidates with a research plan focused on i) cardiometabolic diseases, ii) antimicrobials and antimicrobial resistance, or iii) structural biology.

Job description

The successful applicant should present an ambitious research and teaching plan.

The tenure-track assistant professors’ responsibilities will primarily consist of:

• Research, including publication and academic dissemination of results to the scientific community and the general public, as well as efforts to attract external funding.
• Develop, organize, and conduct research-based teaching, including associated examination.
• Research leadership, including guidance and supervision of students
• Obligation to share knowledge with the rest of society, including participation in public debate
• Academic assessments
• Engage in outreach and/or innovation activities both within the Department and towards academia, the clinic, and industry in general.
• Participation in formal pedagogical training programme for assistant professors

The tenure track assistant professor’s performance will be evaluated through annual evaluations. Furthermore, the tenure track assistant professor will be evaluated in a mid-track appraisal.

After no more than six years of employment and on condition of a positive final appraisal, the tenure track assistant professor will be employed as associate professor. Find more information about tenure track at the University of Copenhagen.

Qualifications of the applicant

When evaluating applicants, primary emphasis will be placed on the applicant's ability to document original scientific work of the highest international standard, an innovative mindset, and strong ambitions for advancing teaching within the fields of biochemistry, pharmacology, microbiology, pharmacotherapy, natural products research, or structural biology, with particular focus on teaching on compulsory courses at the BSc and MSc levels.

Applicants already having sustainability integrated in all aspects of their research and teaching, or a clear plan for doing so, will have preference. Likewise, a clear and structured plan for internal and external collaborations will be given positive consideration. Finally, alignment with the department’s 2030 research vision (https://drug.ku.dk/about/) will be evaluated positively.

Overall criteria for the position:

Six overall criteria (research, teaching, societal impact, organizational contribution, external funding, and leadership) are considered a framework for the overall assessment of candidates at each of the academic levels. Find information about the criteria for assistant professors here:

https://jobportal.ku.dk/videnskabelige-stillinger/kriterier-for-videnskabelige-stillinger/dokumenter-til-meritering/5a_Criteria_for_recognising_merit_-Assistant_professors.pdf 

Applicants at are also required to possess good interpersonal and communicative skills.

Desired qualifications:

• A PhD degree or similar qualifications within the subject area
• Research profile within one of the above-mentioned research directions
• Experience in attracting external funding
• Experience in innovation
• Strong commitment for the development of innovative and student-centred research-based teaching
• Interest and experience in applying modern data science methods within research and teaching

Terms of employment
The position is a permanent position. The average weekly working hours are 37 hours per week.

Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Taxation and AC (Danish Confederation of Professional Associations) or other relevant professional organisations. The position is covered by the Job Structure for Academic Staff at Universities 2025.

Questions
For further information, please contact Head of Department Dan Stærk, ds@sund.ku.dk. For information about the Department of Drug Design and Pharmacology and the Faculty of Health and Medical Sciences (SUND), please see www.drug.ku.dk and https://sund.ku.dk/.

Foreign applicants may find this link useful: https://www.ism.ku.dk/ (International Staff Mobility).

Application
The application must be submitted in English and must include the following documents:

• Application, including motivations for applying for the position (maximum 2 pages)
• Curriculum vitae, including information about external funding
• Diplomas (Master’s, PhD, and other relevant certificates)
• A complete list of publications
• Research plan (3-5 pages) outlining the proposed activities for a six-year period
• Uploads of maximum 5 publications to be considered in the assessment
• Teaching plan
• Teaching portfolio (Guidelines: https://employment.ku.dk/faculty/recruitment-process/job-application-portfolio)

Please note: It is mandatory to upload a teaching plan in the online application form. Should you not be able to produce a teaching plan, please upload a blank document in this box instead.

Please note: It is mandatory and a part of the application process to complete the ‘Executive summary’ form, which you will find when you click on “Apply for position”

Application procedure
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are immediately notified whether their application has been passed for assessment. The Dean then appoints an expert assessment committee in order to make an assessment of the selected applicants for the specific post. Selected applicants are notified of the composition of the committee, and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at https://jobportal.ku.dk/.

The first round of interviews may be conducted either on-site or on-line. The second round of interviews will be on-site. Candidates selected for the second round interviews may be asked to deliver a research seminar, conduct a teaching session, and participate in one-on-one or small group discussions regarding their research, teaching and innovation plans with selected members of the department’s faculty staff.

Please note that the applicant will be contacted if the assessment committee requires further documentation.

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

The University of Copenhagen encourages all interested applicants to apply for this position.

Please submit the application with the required attachments. The closing date for applications is 23.59 p.m. CET, 20 April 2026.

[Post Date: March 17, 2026]

Description:

A postdoctoral position with a FAPESP fellowship is available for research on the determination of three-dimensional structures of luciferases and photoproteins, within the framework of the FAPESP Thematic Project “Bioluminescence: biodiversity; metabolic origin; structure/function and engineering of luciferases; applications in biosensors, bioassays and environmental bioindication.”

Applicants should have experience in at least one of the following areas:
• Determination of protein three-dimensional structures by X-ray crystallography 
• Heterologous expression and purification of proteins 
• Biophysical techniques applied to the study of protein structure and function

The project will be conducted in Brazil, at the Institute of Physics of the University of São Paulo, part of the University of São Paulo, located in São Paulo, Brazil. The research will be supervised by Atílio Tomazini (IF-USP) and Vadim Viviani (UFSCar).

The opportunity is open to Brazilian and international candidates who obtained their PhD degree within the last seven years. The selection process will take place from March 9 to March 23, 2026, with an expected immediate start date.

Interested candidates should send the following documents in PDF format:
• Motivation letter 
• Curriculum Vitae or FAPESP Curriculum Summary (Súmula Curricular model) 
• Copy of the PhD thesis

Applications should be sent to Prof. Atílio Tomazini (atilio.tomazini@usp.br), with a copy to Prof. Vadim Viviani (viviani@ufscar.br).

[Post Date: March 9, 2026]

Description:

The mission of the postdoctoral researcher is to advance data analysis tools for time-resolved serial X-ray crystallography (TR-SX) and cryo-electron microscopy (cryo-EM). The researcher will focus on the development and optimization of the Xtrapol8 software, as well as the analysis of time-resolved structural data.

The Institute for Structural Biology: The Institute for Structural Biology (IBS, France) is located within the Grenoble Science Park (ESRF/ILL/EMBL/IBS), and is a major national and international player in the field of integrated structural biology. Its mission is to drive forward research in structural biology, key to understanding fundamental biological mechanisms. It is a research center that o!ers access to state-of-the-art technical platforms, provides scientific training and creates opportunities for collaboration. As a joint research unit (CEA-CNRS-UGA), the IBS comprises 20 research groups, each of which o!ers a multidisciplinary approach to study the frontiers of biology, physics and chemistry. The IBS is home to nearly 300 sta! members, comprising researchers, doctoral students, engineers and technicians, working together in a dynamic and multicultural environment.

The DYNAMOP group: The Dynamics and Kinetics of Molecular Processes (DYNAMOP) group, headed by Dr. Martin Weik, studies the structure and dynamics of proteins using X-ray di!raction and scattering, and neutron spectroscopy. The group is divided in two teams: Structural Protein Dynamics (SPD, led by Dr. Martin Weik) and Serial NanoCrystallography (SNaX, led by Dr. JacquesPhilippe Colletier). The group comprises approximately 15 members, including permanent researchers, postdoctoral researchers, PhD students and technicians. The group strives for a mix of nationalities and attaches great important to gender equality and personal well-being. Context of the postdoctoral position: The postdoctoral position is available in the SNaX team, which specializes in serial (time-resolved) crystallography and developing software for time-resolved X-ray crystallography (NanoPeakCell and Xtrapol8). The project will be conducted under the supervision of and in close collaboration with Dr. Elke De Zitter, Dr. Jacques-Philippe Colletier and Dr. Nicolas Coqulle, all permanent members in the DYNAMOP group. The postdoctoral project is within the framework of a collaboration with the CristallinaMX group (Paul Scherrer Institut (PSI), SwissFEL, Switzerland).

Main activities: The main activities are in function to improve and expand Xtrapol8:
• Develop tools for bootstrapping, and singular value decomposition.
• Improve the methods and theoretical basis to estimate occupancy.
• Implement real-space methods.
• Modularize and parallelize the Xtrapol8 code.
• Analyze time-resolved crystallographic and cryo-EM datasets.
• Participate in TR-SX experiments at SwissFEL.
• Publish results in peer-reviewed journals and present findings at international conferences.
• Work closely with the DYNAMOP group at IBS and the CristallinaMX team.

Required and preferred skills and competences:
• PhD in Mathematics, Physics, Computational Biology, Structural Biology, Biophysics, or a
related field.
• Strong programming skills in Python. Experience with other programming languages is advantageous.
• Familiarity with time-resolved techniques in crystallography or cryo-EM is highly desirable.
• Proven track record of scientific publications in peer-reviewed journals.
• Excellent written and oral communication skills in English (minimum B2 level). French language skills are beneficial. Non-French-speaking candidates are expected to acquire a basic proficiency in French to facilitate communication and integration into the laboratory.
• Ability to work independently and collaboratively in an international team.

Application instructions: Interested candidates should send their application to Dr. Elke De Zitter (elke.de-zitter@ibs.fr) and Dr. Jacques-Philippe Colletier (colletier@ibs.fr). The application should contain a cover letter detailing motivation and relevant experience and a curriculum vitae, including a list of publications and contact information for 2-3 references.

More Information:
Contract Type Fixed-term (CDD)
Duration 36 months
Expected Start Date 01/05/2026 (flexible)
Work Quota Full-time
Contact information Dr. Elke De Zitter; elke.de-zitter@ibs.fr
Dr. Jacques-Philippe Colletier (colletier@ibs.fr)

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