Banner Image

Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Crystallographer Sosei Heptares

View the Job Posting Here

job posting image

Description:

Company Description

Sosei Heptares (the corporate brand of Sosei Group Corporation) is a research-focused biotechnology group, publicly listed in Japan (TSE: 4565) and with sites in Tokyo, London and Cambridge (UK).

Our mission is to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected StaR® technology and platform.

Our primary focus is the discovery and early development of new medicines originating from our proprietary G Protein-Coupled Receptor (GPCR)-targeted StaR® technology and Structure-Based Drug Design (SBDD) platform capabilities. We are advancing a broad and deep pipeline of novel medicines across multiple therapeutic areas, including CNS, immuno-oncology, gastroenterology, inflammation and other rare/specialty indications.

We have established partnerships with some of the world’s leading pharmaceutical companies, including Abbvie, AstraZeneca, Genentech (Roche), Novartis, Pfizer and Takeda; and additionally, with multiple emerging biotechnology companies.

Sosei Heptares has approximately 147 employees based at its new R&D research facility at Granta Park. The size of the company ensures a transparent linkage between all activities from early discovery through to clinical development.

Position

We are currently seeking an experienced protein crystallographer to join the crystallography group working on GPCR structure determination to enable drug discovery efforts.

This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company.

The successful candidate is expected to work independently and:

   Express and purify GPCRs for structural and biophysical methods

   Set up and optimise vapour diffusion and LCP crystallisation experiments

   Collect X-ray diffraction data at synchrotron sources

   Solve and refine structures

   Present results (written and oral) to internal and external audiences.

Requirements

Our preferred candidate will have the following:

   PhD in protein crystallography or related discipline and be familiar with purification of proteins from recombinant expression systems such as E. coli or baculovirus/insect cells, setting up crystallisation experiments including Lipidic Cubic Phase crystallisation, X-ray data collection, data processing, structure solution and refinement of novel structures and follow on complexes.

   Proficiency with single particle cryo-electron microscopy techniques would be a distinct advantage

   Experience working with GPCRs or other membrane proteins would be also be advantageous.

   Experience of working in a drug discovery environment where structural studies are used to drive compound design and medicinal chemistry would also be of benefit.

Other information

Applicants must be able to demonstrate proof of the right to work in the United Kingdom.

The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation.

We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes.

Applications should include a covering letter, providing a short description of the background to their interest in the role, with curriculum vitae including the names and contact details for two referees. Please apply through our on-line jobs portal with your application in pdf format, quoting reference number 2020-6BMS.

The closing date for applications is 4th September 2020

Strictly No Agencies


[Post Date: August 4, 2020]


Research Technician Position in Djinovic Group

job posting image

Description:

Research technician position is available in the Djinovic-Carugo laboratory in the Department for

Structural and Computational Biology, Max Perutz Laboratories of the University of Vienna, Austria.

The Position

You will provide specific technical support to a research projects related to structural biology of muscle Z-disk interactome, and assist in the lab on a variety of biochemical, biophysical and structural studies, including gene cloning, protein expression, purification, and characterization of purified protein by various biochemical and biophysical techniques. You are also expected to help with the management of the laboratory, together with lab-manager of the research group.

The Candidate

We are looking for a highly motivated candidate who is enthusiastic about working in an ambitious and

multidisciplinary team and fits the following profile:

•       Degree in Biochemistry, Chemistry, Molecular Biology, or a related field (MTA, CTA, B.Sc., M.Sc., Mag., DI)

•       Excellent understanding of the theoretical and technical principles of conventional techniques in protein biochemistry and molecular biology, such as molecular cloning, protein expression and purification and biophysical characterization. techniques, protein purification, biochemistry is needed; experience in insect and/or mammalian cell culture is an asset. Experience with biophysical characterization and structure determination will be highly valued.

•       High accuracy, reliability and excellent interpersonal and organizational skills are a requirement.

•       She/He should be willing to acquire further skills and contribute to the development of new methods.

•       The working language in Max Perutz labs is English, excellent command of English (spoken and written) is a must, German skills are an asset. Computer literacy and experience of using Microsoft is essential.

The Laboratory

Djinovic Lab is interested in the molecular mechanisms underlying the architecture and assembly of the striated muscle sarcomeres, in particular Z-discs. We use an integrative structural biology approach combining biophysical and high-resolution structural studies (macromolecular crystallography being the main technique) with lower resolution approaches (small-angle scattering, electron microscopy) combined with chemical cross-linking mass-spectrometry and NMR.

The Institute

The Department for Structural and Computational Biology is equipped with state-of-the-art instrumentation/facilities to carry out all steps from cloning, protein expression and purification, to X-ray diffraction, biomolecular NMR, as well as for a series of biophysical and optical spectroscopy techniques. The Department is part of the Max Perutz Labs, established by the University of Vienna and the Medical University of Vienna to provide an environment for excellent, internationally recognized research and education in the field of Molecular Biology. Dedicated to a mechanistic understanding of fundamental biomedical processes, scientists at the Max Perutz Labs aim to link breakthroughs in basic research to advances in human health. Perutz Labs are located on Vienna Campus Biocenter, which is the largest life sciences hub in Austria. Vienna Campus Biocenter offers access to excellent Scientific Core Facilities. Vienna is frequently ranked as the world’s best city to live in. It is a United Nations city with a large English-speaking community.

The Offer

We offer a challenging position in dynamic and multidisciplinary team and contribute to our research on fascinating Z-discs assembly within a highly international environment. This is a 30-35 h/week post for up to 6 years, subject to successful evaluation after one year. The post is funded by the University of Vienna, and is available for start in October 2020. This position is remunerated with a minimum gross salary according to collective agreement of Univ. Vienna, 33.903,80 Euro for 40 hours/year, definite salary depends on the previous experiences.

Application details: if you want to join an exciting project and become a member of our interdisciplinary team, please compile an application package containing:

•     Letter of interest

•     Your CV

•     Contact details for two references

And submit your application to Kristina Djinovic Carugo (to e-mail: admin.vbc5@univie.ac.at) by September 21st, 2020. Review of applications will begin immediately.


[Post Date: August 4, 2020]


Structural Biology & Biophysics Scientist (PROTAC drug discovery)

View the Job Posting Here

job posting image

Description:

We have a particularly exciting job opportunity in our lab, the PROTAC drug discovery collaboration between the group of Prof Alessio Ciulli at the University of Dundee and Boehringer Ingelheim. Our group are world leaders in the field of PROTACs, which has rapidly become one of the hottest topics in drug discovery. We are looking to recruit one new team member to help expand our structural biology, protein production and biophysical efforts. 


If you have relevant doctoral/post-doctoral experience and are interested in joining a highly motivated, dynamic, interdisciplinary group at the interface of academia and industry, the deadline for application is Sunday 30th August. The post is available to start on 1st September 2020 and is for 3 years. Salary will depend on experience, but the appointment will be at Grade 7 on the University's salary scale (between £32,817 - £40,322). The full job advert including details on how to apply can be found at https://ig5.i-grasp.com/fe/tpl_uod01.asp?newms=jj&id=104360&aid=14197 


[Post Date: August 4, 2020]


Postdoc UT Health Science Center, San Antonio, Texas

job posting image

Description:

The laboratory of Dr. Yogesh Gupta at University of Texas Health Science Center in San Antonio is seeking an enthusiastic Postdoctoral Fellow to study the structure and function of nucleoproteins in infectious diseases and cancer. We combine structural biology tools (X-ray, cryo-EM, NMR) with cell-based methods to address mechanistic questions and exploit this knowledge for drug development. Please visit below websites to learn about our research program –

https://www.nature.com/articles/s41467-020-17496-8

http://ccri.uthscsa.edu/YGupta.html

Preference will be given to applicants with demonstrated experience in macromolecular crystallography. Candidates are expected to possess strong organizational, interpersonal skills, and ability to work as part of a team. An ideal candidate should hold (or soon expect to hold) a Ph.D. or equivalent degree in biochemistry/biophysics/structural biology and have no more than 2 years of postdoc experience.

Salary is competitive. San Antonio offers affordable cost of living and there is no state income tax in Texas. If interested in applying, please send a short description of your research accomplishments, and CV with a list of 3 references to Dr. Yogesh Gupta (email: guptay@uthscsa.edu).

The Greehey Children’s Cancer Research Institute is a unique specialized cancer research center focusing on basic and translational research in childhood cancer and occupies a state-of-the-art 100,000 sq. foot research facility on the university’s Greehey Academic and Research Campus. San Antonio is the nation’s seventh largest city and is located at the edge of the beautiful Texas Hill Country. San Antonio offers a rich, multi-cultural community, affordable cost of living, excellent weather and a thriving biomedical industry. All Postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Opportunity/Affirmative Action Employer including protected veterans and persons with disabilities.


[Post Date: August 3, 2020]


Postdoc University of Pittsburgh, Protein Design and Engineering for Drug Development

job posting image

Description:

Description: a postdoctoral position is available in the Shi laboratory of antibody biotechnology and proteomics at the Department of Cell Biology, University of Pittsburgh School of Medicine (UPMC). The laboratory is at the forefront of developing transformative new technologies that integrate proteomics, computational biology, and structural approaches for large-scale antibody (especially camelid VHH antibody/ nanobody) discovery and characterization.  The lab is also interested in applying these techniques to develop novel nanobody-based therapies for some of the most devastating diseases including COVID-19, cancer, and neurodegeneration. The lab is currently funded by several grants including the NIH, MJFF, and Alzheimer Foundation. More information about our research could be found here at www.shi-lab.org. For the successful incumbent, the initial appointment is 12 months with the possibility of renewal. Compensation will follow standard NIH Post-Doc salary rates and is based on experience. We strongly support the career development of our colleagues and trainees. A listing of Pitt employee benefits is available at https://www.hr.pitt.edu/current-employees/benefits

Highly motivated individuals with a background in biochemistry, bioengineering, biophysics or structural biology (especially membrane protein structural biology) are welcome to apply. Successful candidates should have excellent communication skills and the desire to lead research projects. Interested candidates may submit their CV including names and contact information for two-three references, a short description of their research experience, and research goals to Yi Shi at (yi.shi@pitt.edu). For more information about our research visit: https://www.shi-lab.org/

Pittsburgh: As the second-largest city in Pennsylvania, Pittsburgh is best known as "the city of Bridges". In 2015, Pittsburgh was listed among the "eleven most livable cities in the world" and has been considered as one of the most livable cities in the United States.

The University of Pittsburgh is an Equal Opportunity Employer.


[Post Date: August 3, 2020]


Sanofi Postdoctoral Fellowship: Computational Scientist for Antibody Engineering (Framingham, MA)

View the Job Posting Here

job posting image

Description:

The Protein Engineering group within Sanofi Large Molecule Research Department is seeking a highly talented Computational Scientist for a postdoctoral position. We use leading-edge structural biology and computational tools to support biologics project needs from Sanofi’s multi-targeting, multi-modality research pipeline. Our team has a great track record of patents and publications, including Science, Nature Cancer, and Nature Communications, in the area of biologics characterization, antibody engineering and multi-specific antibodies. This postdoc project will focus on developing a machine learning approach to predict epitope-paratope, given any antibody-antigen pair, by combining in-depth understanding of structure biology, antibody engineering, and large datasets both internally and externally. The successful candidate will be with Ph. D. degree in related area and has an advanced understanding and practical experience with developing and applying complex machine learning solutions for structural biology data. The successful candidate will gain deeper insight into drug development process and transform AI/ML algorithms into accelerating biologics discovery and development process.

Application Link: https://sanofi.wd3.myworkdayjobs.com/en-US/StudentPrograms/job/Framingham-MA/Sanofi-Postdoctoral-Fellowship--Computational-Scientist-for-Antibody-Engineering--Framingham--MA-_R2552646

About Sanofi:

Every day, Sanofi's 100,000 employees are committed to improve the lives of people around the world, with sustainable and responsible solutions and initiatives. Sanofi is recognized as one of the leading biopharmaceutical companies in the world and is pioneering innovation in biologics with the first approved nanobody drug, the first clinical stage tri-specific antibody, and a novel genetic codon expansion platform for new engineering capabilities. Details of the organization and the company’s mission and goals can be found on our website (http://www.sanofi.us/l/us/en/index.jsp).


[Post Date: August 3, 2020]


Research Scientist for the Centre of Molecular Structure ‐ Biophysical Methods Facility

job posting image

Description:

The Institute of Biotechnology of the Czech Academy of Sciences at BIOCEV Centre (Biotechnology and
Biomedicine Center of the Academy of Sciences and Charles University) in Vestec announces an open position:


Research scientist for the Centre of Molecular Structure ‐ Biophysical methods facility


The central facility of Biophysical methods is a part of the Centre of Molecular Structure (CMS belongs to the
Czech Infrastructure for Integrative Structural Biology, https://www.ciisb.org/ and to the European
infrastructure Instruct‐ERIC, https://instruct‐eric.eu/). It is equipped with a number of biophysical methods for
characterization of proteins, nucleic acids, and their complexes. The individual techniques are used either for
determination of the key properties of biomolecular samples or assessment of their interaction characteristics.
For details about the installed equipment and provided services refer to the web pages of CMS at
https://www.ibt.cas.cz/en/core‐facilities/centre‐of‐molecular‐structure/.


We are looking for a research scientist with a significant experience in application of biophysical techniques
and/or spectroscopic techniques.


Job description:
We offer attractive work and professional growth in the field of biophysics in the center of excellence Biocev
with use of modern instruments. The main responsibility lies in provision of services and high‐level expertise at
the Centre of molecular structure in biophysical methods, with the possibility of focus on spectroscopies. The
Research scientist will provide services (measurements and analysis where required), guarantee quality and
efficiency of the provided services to internal and external users, will participate in advertising of the services
to external users, including commercial utilization of the services. The Research scientist will be involved in the
activities of research infrastructures on national and international levels (CMS is a part of the Czech
infrastructure for integrative structural biology and is also involved in the European infrastructure Instruct). The
Research scientist will also participate in training within his/her field of expertise and development of services
of an associated facility with optical tweezers with confocal microscope and time‐resolved biophysical
approaches.


Requirements:
• University education in one of the following fields: biophysics, biochemistry, physics, chemistry,
structural biology, or closely related
• Ph.D. degree or equivalent
• Research experience in biophysics and/or IR, fluorescence or other spectroscopies; experience in
time‐resolved approaches or structural biology methods is welcome
• Publication activity in the field
• Excellent communication skills and teamwork
• Proven organizational abilities
• Readiness for high work load
• English, written and spoken, advanced level (C2)
• Good repute
Start date: immediately

Workplace location: Vestec near Praha


Send written applications including a motivation letter and a professional CV, either in printed or electronic
form to address: Institute of Biotechnology of the Czech Academy of Sciences, Prumyslova 595, 25250 Vestec,
Czech Republic, btu‐office@ibt.cas.cz


Application deadline: August 31, 2020


We hereby inform you that the Institute of Biotechnology of the Czech Academy of Sciences shall process your personal data
only to the extent for the purposes of selection of a suitable employee and closure of a contract of employment in accordance
with the General Data Protection Regulation 2016/679 (GDPR).

 Download PDF

[Post Date: August 3, 2020]


Computational Biology Scientist, Machine Learning in Large Molecule Research

View the Job Posting Here

job posting image

Description:

About the Company:

Every day, Sanofi's 100,000 employees are committed to improve the lives of people around the world, with sustainable and responsible solutions and initiatives. Sanofi is recognized as one of the leading biopharmaceutical companies in the world and is pioneering innovation in biologics with the first approved nanobody drug, the first clinical stage tri-specific antibody, and a novel genetic codon expansion platform for new engineering capabilities. Details of the organization and the company’s mission and goals can be found on our website (http://www.sanofi.us/l/us/en/index.jsp).

Overview:

Sanofi Large Molecule Research Platform is opening a new scientist/senior scientist role to seek a computational biologist with strong expertise in computational biology, bioinformatics, artificial intelligence (AI), machine learning (ML), and deep learning (DL).  The successful candidate will work in an interdisciplinary team to apply cutting-edge computation, AI/ML/DL, and structural biology technologies to resolve challenges in real-world drug discovery and make impacts to patients’ life. This is an exciting opportunity to contribute to the process of design and engineering revolutionary biologics, including multivalent, multi-targeting molecules by leveraging proprietary data coming from our industry-leading high-throughput automation platforms. The successful candidate will gain deeper insight into drug development process and transform AI/ML algorithms into accelerating biologics discovery and development process.

Your responsibilities include:

o   Evaluate and develop state-of-the-art computational methods to decode biophysical and geometrical features from antibody-antigen datasets and create predictive models for engineering.

o   Develop and apply complex machine/deep learning solutions to our high-content and high-quality proprietary datasets, as well as public datasets.

o   Perform data querying and feature extraction to improve current workflow for antibody/nanobody engineering, including affinity modification, cross-reactivity engineering, liability risk prediction and mitigation, multi-specific antibody engineering, and de novo antibody design.

o   Maintain a keen awareness of recent developments in data science, bioinformatics, and state-of-the-art of AI/ML/DL algorithms, aiming to accelerate development of new computational algorithms.

o   Effectively collaborate with colleagues with diverse scientific background, identify problems and opportunities, combine computational and structural analysis to support large molecule projects.

Basic qualifications:

o   MS with 5+ years’ or Ph. D. with 0-5 years’ experience in computational structural biology, bioinformatics, computational chemistry, or computational physics, with significant experience in data science and machine learning.

o   Understanding of protein structure and protein-protein interaction. Hands-on experience with structural analysis and optimization of biochemical and biophysical properties, like thermodynamics, with protein design tools e.g. Rosetta, BioLuminate, or MOE, etc.

o   Strong familiarity with core concepts in Deep Learning and Neural Networks including CNNs, RNNs, Embeddings, Transfer Learning, Attention-based Networks, Statistical Learning.

o   Familiarity with deep learning libraries such as Keras, TensorFlow, PyTorch, and bioinformatics pipelines

o   Experience of developing computational prediction models for protein engineering through programming with Python, Shell, or SVL, etc.  Experience with cloud computing, parallel computing, and/or supercomputing is expected.

o   Familiarity with protein structure or sequence featurization and learned embeddings. Experience with database mining, big data, and large-scale virtual screening using Bayesian optimization etc is desired.

o   Familiarity with Data Visualization tools/libraries and dimensionality reduction algorithms.

Preferred qualifications:

o   Understanding of biologics R&D process is a plus.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

#GD-SA

#LI-SA

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.


[Post Date: July 30, 2020]


Senior Associate – Protein Expression

View the Job Posting Here

job posting image

Description:

Category: Scientific
Job ID: R-102000
Location: Burnaby, BC, CA
Additional Location: Canada - Mississauga
Posted Date: 7/24/2020

Summary

Amgen is a global biotechnology company that discovers and develops breakthrough therapies to treat serious human illnesses. Our mission is to serve patients around the world and our medicines have made a dramatic difference in the lives of millions.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world’s leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Amgen’s Therapeutic Discovery organization is seeking an enthusiastic, collaborative Senior Associate to join the Protein Technologies group at our Amgen British Columbia site. Protein Technologies is responsible for designing, planning and executing on the generation of key enabling reagents to support discovery of small and large molecule therapeutics and cutting-edge novel modalities.

Well-suited applicants will have a strong scientific background in recombinant protein expression in mammalian host systems, a deep scientific curiosity, and a positive approach to working in a team-based research environment. These individuals will also have a track record of creative problem-solving and enthusiasm for tackling difficult research challenges.

Responsibilities

  • Work within the Protein Technologies team to deliver high quality protein reagents to support the early pipeline
  • Grow and maintain cell lines for transient and stable transfections
  • Express a wide variety of protein classes, including soluble proteins, antibodies, and antibody fusions in mammalian cell hosts (HEK293, CHO) by transient and stable expression methods
  • Determine protein expression levels using SDS-PAGE, Western Blot, and Octet
  • Analyze and interpret scientific data, document experiments in lab notebooks and LIMS, and multi-task with focus on detail in a fast-paced environment
  • Leverage strong communication skills in planning and coordinating experiments and sample hand-offs with team members and partner functions

Basic Qualifications

Master’s Degree

OR

Bachelor’s degree and 2 years of scientific experience

Preferred Qualifications

  • Expertise in recombinant protein expression, including:

o   Mammalian tissue culture and aseptic technique

o   Recombinant protein expression in HEK293 and/or CHO

o   SDS-PAGE and Western blot analysis

o   Familiarity with Octet titer measurements

  • Demonstrated scientific analysis and problem-solving skills
  • Strong written and verbal communication and interpersonal skills
  • Desire to be a team player in a dynamic, cross-functional environment

Amgen endeavors to make its recruitment process accessible to any and all users. Reasonable accommodations will be provided, upon request, to applicants with disabilities in order to facilitate equal opportunity throughout the recruitment and selection process. Please contact TalentAcquisitionInquiries@amgen.com to make a request and ensure you include the requisition number.

Reasonable accommodations are available, upon request, to facilitate the equal participation of candidates with disabilities, should you be selected for an interview.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

http://careers.amgen.com/ShowJob/JobId/453495/


[Post Date: July 30, 2020]


Senior Scientist – Protein Technologies Team Lead

View the Job Posting Here

job posting image

Description:

Category: Scientific
Job ID: R-102328
Location: Burnaby, BC, CA

Title: Senior Scientist – Protein Technologies Team Lead

Reports to: Principal Scientist

Location: Burnaby

JOB SUMMARY

Amgen is a global biotechnology company that discovers and develops breakthrough therapies to treat serious human illnesses. Our mission is to serve patients around the world and our medicines have made a dramatic difference in the lives of millions.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world’s leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Amgen’s Therapeutic Discovery organization is seeking an enthusiastic, collaborative Senior Scientist team lead to join the Protein Technologies group at our Amgen British Columbia site. Protein Technologies is responsible for designing, planning and executing on the generation of key enabling DNA and protein reagents to support discovery of small and large molecule therapeutics and cutting-edge novel modalities.

As a team lead within Protein Technologies, you will be responsible for managing a high-performing team with a mandate to produce high quality reagents to support the Amgen pipeline. You will be responsible for the operational, strategic, and scientific management of the group and will also actively participate in the science through hands-on lab work and implementation of enabling technologies and automation. You will also be responsible for aligning with our Protein Technologies group in South San Francisco and for initiating and driving collaborations with partner functions such as such as Antibody Discovery, Therapeutic Areas, and Molecular Structure.

Well-suited applicants will have a strong scientific background in recombinant protein expression, purification, and analytics, a deep scientific curiosity, and demonstrated success in project and personnel management.

Basic Qualifications

Doctorate degree and 3 years of Scientific experience
OR
Master’s degree and 6 years of Scientific experience
OR
Bachelor’s degree and 8 years of Scientific experience

Preferred Qualifications

  • Ph.D. in Biochemistry, Biophysics, Chemistry or Molecular Biology and postdoc from a leading institution or biotechnology company
  • 4+ years of industry experience
  • A track record of scientific accomplishments and project leadership in biologics drug development as evidenced by peer-reviewed publications, patents, or pipeline contributions
  • 2+ years of managing a high-performing team with a focus on protein expression, purification, and analytics
  • Expertise in recombinant protein expression in transient and stable mammalian hosts such as HEK293 and CHO
  • Expertise in purifying a range of different protein types (e.g. extracellular domains, glycoproteins, monoclonal and multi-specific antibodies, membrane proteins) using multiple chromatographic methods (e.g. affinity, ion exchange, size exclusion)
  • Expertise in protein analytics, including HPLC-SEC and LC-MS
  • Experience with increasing productivity through automation
  • Microbial protein expression experience
  • Familiarity with processes in antibody discovery
  • Strong written and verbal communication and interpersonal skills
  • Ability to inspire and grow a high-performing team, chart and set team goals into action, and forge productive cross-site collaborations with partner functions

Amgen endeavors to make its recruitment process accessible to any and all users. Reasonable accommodations will be provided, upon request, to applicants with disabilities in order to facilitate equal opportunity throughout the recruitment and selection process. Please contact TalentAcquisitionInquiries@amgen.com to make a request and ensure you include the requisition number.

Reasonable accommodations are available, upon request, to facilitate the equal participation of candidates with disabilities, should you be selected for an interview.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

http://careers.amgen.com/ShowJob/JobId/454113


[Post Date: July 30, 2020]


Postdoc Institute for Protein Innovation, Boston, USA

View the Job Posting Here

job posting image

Description:

The Bahl Lab at the Institute for Protein Innovation (IPI) in Boston is recruiting Postdoctoral Fellows. We use protein design to accelerate drug discovery and to engineer new lead therapeutic molecules. In addition to traditional academic collaborations, we work closely with pharmaceutical and biotech companies, as well as venture capital firms.

We are looking for translationally-minded scientists who want their work to have a direct impact on the world. We will provide training in computational protein design using Rosetta, including de novo protein design and the design of protein function and biophysical properties. Postdoctoral Fellows at IPI leverage our high-throughput automated laboratory infrastructure.

We are especially excited to expand our work in the following research areas:

  • prediction and design of protein developability for therapeutic applications
  • engineering of de novo miniprotein/peptide lead therapeutics for oncology, infectious disease, hypertension and diabetes, etc.
  • antibody design, including de novo paratope design
  • enzyme design

Strong candidates will have demonstrated expertise in one or more of the following:

  • protein biochemistry: protein production and biophysical characterization, enzymology
  • structural biology: cryo-EM, X-ray crystallography, NMR
  • immuno-oncology: cell culture models, fluorescence activated cell sorting
  • traditional protein engineering: directed evolution, library construction, yeast and/or phage display
  • computational biology: machine learning, data science, molecular dynamics and/or modeling

If you are excited to join a team of protein designers working to tackle audacious projects aimed directly at improving human health, please send your CV to: chris.bahl@proteininnovation.org

About IPI 

The Institute for Protein Innovation is a non-profit organization that is advancing protein science to accelerate research and improve human health. The Institute is located at Harvard Medical School. IPI uniquely combines the freedom of academic exploration with the high-throughput scaling of industry to take on transformative protein-based initiatives that no other laboratory or organization can or will pursue. IPI is deploying state-of-the-art technologies to build a repository of powerful protein tools and reagents and share them through licensing and collaboration. These will enable new biomedical and therapeutic discovery for researchers in academia and industry alike. This constellation of vanguard technology and expertise positions IPI to train the next generation of entrepreneurs and protein scientists to lead the discovery of new medicines. 


The IPI is an equal opportunity employer and prohibits discrimination based on ethnicity, religion, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, socioeconomic status, marital or veteran status, etc. Candidates from underrepresented backgrounds are especially encouraged to apply.


[Post Date: July 30, 2020]


Scientist/Senior Scientist - Protein Purification - Abingdon Evotec

View the Job Posting Here

job posting image

Description:

Required Knowledge, Skills and Abilities:

  • Extensive knowledge of protein purification, demonstrated through the delivery of innovative solutions for drug discovery programs
  • A working knowledge and practical experience with AKTA systems will be highly advantageous
  • The successful candidate will have experience working in multi-disciplinary teams
  • Experience collaborating with scientists in external organisations would be an advantage

Responsibilities may include:

  • Supporting a project team by conducting experiments with defined, agreed objectives and timelines
  • Contributing to the design, execution and interpretation of experiments in a project team to accomplish project goals
  • Adapting scientific knowledge to resolve problems encountered in achieving defined goals with assistance from line manager or other team members to meet internal and project deadlines
  • Preparing reports of findings, presenting data, and collaborating with other scientists at Evotec
  • Presenting own work at project technical meetings, and department technical meetings when required
  • Demonstrating full command of all techniques and tools required for assigned responsibilities within the given project
  • Ensuring safe working practices of themselves and any direct reports
  • Complying fully with the company safety policy (including COPs and SOPs) when performing experiments
  • Reading scientific literature relevant to the project
  • Adhering to Lab Notebook guidelines regarding accurate documentation of lab experiments

Desirable Knowledge, Skills and Abilities:

  • Self-motivated, enthusiastic, cooperative and reliable
  • Knowledge of basic laboratory techniques, and understanding of the science underlying the techniques and experiments
  • Experience of working in a lab environment
  • The ability to adapt to changing demands whilst operating under pressure to deadlines
  • The ability to work accurately and with attention to detail
  • Good interpersonal skills and the ability to work well with other scientific staff
  • The ability to work well independently, and as part of a team
  • Good organisational and time management skills
  • Good verbal communication skills
  • Ability to maintain excellent laboratory records
  • Computer proficiency

Education and Experience:

  • PhD, MSc, BSc degree or equivalent in Biochemistry or related area

Candidates must be eligible to work in the UK.


[Post Date: July 30, 2020]


Visiting Research Specialist Position at the University of Illinois to Study Ribosome Structure

View the Job Posting Here

job posting image

Description:

The Polikanov Laboratory at the University of Illinois at Chicago (IL, USA) is looking for a talented, skillful, and highly motivated researcher to fill the Visiting Research Specialist position to study the structure and function of the bacterial ribosome.

The research in the Polikanov Laboratory is focused on understanding the basic principles of protein synthesis in bacteria, the modes of action of ribosome-targeting antibiotics, and the mechanisms of drug resistance at a structural level. More information about Dr. Polikanov's research can be obtained from the most recent publications (https://www.ncbi.nlm.nih.gov/sites/myncbi/yury.polikanov.1/bibliography/50395623/public/?sort=date&direction=descending) or found on the laboratory web-page (https://bios.uic.edu/bios/people/faculty/yury-polikanov). The successful candidate will be involved in the determination of high-resolution structures of ribosome functional complexes with various protein translation factors, tRNAs, and antibiotics using macromolecular X-ray crystallography and potentially cryo-EM techniques.

Basic qualifications:

  • BS degree in chemistry, biochemistry, biophysics, or a related field;
  • MS degree or higher is preferred;
  • Minimum 3 years of laboratory research experience;
  • Strong background in biochemistry and molecular biology;
  • Practical skills with the most standard methods currently used in molecular biology, and biochemistry (such as protein expression, purification);
  • Experience in structural biology (cryo-EM or X-ray crystallography) is desired;
  • Experience in RNA biology is desired.

The successful candidate is also expected to:

  • Act independently in terms of planning and executing the experiments;
  • Compile, analyze, and prepare data for publications;
  • Assist with training of graduate and undergraduate students.

For fullest consideration, please submit an application and cover letter describing your scientific interests and how your previous research accomplishments and scientific interests fit with the scope of the research in the Polikanov research group at https://jobs.uic.edu/job-board/job-details?jobID=133847 by August 14, 2020.

The University of Illinois at Chicago is an Equal Opportunity, Affirmative Action employer. Minorities, women, veterans, and individuals with disabilities are encouraged to apply. The University of Illinois may conduct background checks on all job candidates upon acceptance of a contingent offer. Background checks will be performed in compliance with the Fair Credit Reporting Act.

 Download PDF

[Post Date: July 28, 2020]


Postdoctoral position at Brown University

job posting image

Description:

The Deaconescu Lab at Brown University has one opening for a postdoctoral researcher. The laboratory's interests lie primarily in stress responses, with particular emphasis on responses to DNA damage and the mechanochemistry of DNA-based motors. We utilize a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, small-angle X-ray scattering, transmission electron microscopy). Examples of work are: Brugger et al, Nature Communications (2020), Dorich et al, Genes & Development (2019), Vemu et al. Science (2018), Le TT et al. Cell (2018), Deaconescu et al. Photochemistry and Photobiology (2017), Kutter et al. JMB (2016), Szyk et al, Cell (2014), Deaconescu et al., PNAS (2012), Szyk et al., NSMB (2012) and Deaconescu et al., Cell (2006).

 A successful candidate should have an established track-record of publications in peer-reviewed journals; solid experience with protein biochemistry (including their purification from E.coli/yeast,  functional characterization and assay development).  Prior knowledge of crystallography and/or single-particle electron microscopy is highly desirable. Must be highly motivated and work independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply. 

Interested candidates should send a CV, a one page research experience summary and contact information for three references to alexandra_deaconescu[at]brown.edu. Please use “postdoctoral candidate” as a subject.

Salary and starting date are negotiable.   Please write Postdoctoral Candidate in the e-mail subject header.   Brown University, an Ivy League school, is located in Providence, Rhode Island less than one hour away by train from Boston.   Rhode Island provides plenty of opportunities for outdoor recreation with beautiful beaches and sailing.

Lab webpage: https://deaconesculab.com    


[Post Date: July 27, 2020]


SGC Toronto - Postdoctoral Position in Structural Biology

View the Job Posting Here

job posting image

Description:

POSITION TITLE: Postdoctoral Position – Limited Term

DEPARTMENT: Structural Genomics Consortium (SGC), Faculty of Medicine

SUPERVISOR: Dr. Cheryl Arrowsmith

OVERVIEW:

The Structural Genomics Consortium (SGC) in the Faculty of Medicine, University of Toronto invites applications for the Postdoctoral position (Limited Term) to join the SGC’s structural biology team to investigate the structure, mechanism and druggability of human WD-repeat (WDR) domain containing proteins using X-ray crystallography, biochemistry and biophysics. WDRs are protein-protein interaction hubs that are often found in key regulatory complexes involved in ribosomal biogenesis, epigenetic regulation, cell cycle control and DNA repair (see Schapira et al., 2017, https://doi.org/10.1038/nrd.2017.179), (Grebien et al, 2015, https://doi.org/10.1038/nchembio.1859) and (Getlik et al., 2016, DOI: 10.1021/acs.jmedchem.5b01630). Many WDR proteins are associated with diverse diseases, especially cancer, yet the majority of them are understudied. We have demonstrated the druggability of WDR proteins and seek to develop chemical biology tools to elucidate the function and therapeutic potential of select members of this family. This multidisciplinary project is in collaboration with several AI-based drug-discovery companies, academic labs as well as pharmaceutical companies. The successful candidate will have a broad knowledge of protein biochemistry and X-ray crystallography, a passion for scientific research as applied to drug discovery, and be eager to work as a team player in a fast-paced multidisciplinary environment.

QUALIFICATIONS:

  • Ph.D. in biochemistry, molecular biology, structural biology, or related field, with at least one first authored publication in an internationally recognised peer-reviewed journal.
  • Strong experience with recombinant protein expression, and purification, is required.
  • Experience in X-ray crystallography and/or cryo-EM is highly desirable.
  • Experience with in vitro biophysical methods for protein-protein and protein-ligand interaction studies (e.g. DSF, SPR, FP, FRET, ITC, etc…) is valuable.
  • Strong communication skills, particularly the visual presentation of structural data.
  • Ability to work in a team, communicate, and give/receive constructive feedback and high attention to detail, excellent organizational and documentation skills.
  • Experience in preparing manuscripts for submission to peer review publications/journals and presenting findings at meetings and conferences.

To Apply:

Please forward your CV and contact information for 2-3 references to l.halabelian@utoronto.ca with the subject line “WDR Postdoc”. Position will remain open until filled.

The SGC is a not for profit, public-private partnership working with academia and ten pharmaceutical companies to carry out open access research relevant to human health and drug discovery.
www.thesgc.org

The University of Toronto and its affiliated hospital research institutes comprise one of the largest and most productive centers of biomedical research in North America. Located in vibrant downtown Toronto, the University provides an outstanding opportunity for scientific research, and career development.

The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas.
All qualified incumbents are encouraged to apply; however, Canadians and permanent residents will be given priority.

Closing Date: 
Thursday 1st October 2020


[Post Date: July 23, 2020]


Two postdoctoral research positions in structural and biophysical characterization of the human complement system

View the Job Posting Here

job posting image

Description:


Job description

The Gros lab at the Bijvoet Centre for Biomolecular studies is currently seeking two post-doctoral researchers to strengthen our team. The Gros lab studies biomolecular recognition and regulation processes in the area of infection and immunity. The lab has an internationally strong reputation in uncovering the molecular mechanisms that underpin the complement system. We combine protein crystallography, cryo-electron microscopy, light microscopy, biochemical and biophysical assays to get a detailed picture of the molecular interactions that enable the complement system to discriminate between healthy self-cells and pathogens or dying/malignant cells. The goal of the current projects is to understand how the molecular mechanisms of complement attack and defence on cell membranes determines whether a cell is destined for clearance or not. These are challenging projects that involve several large, flexible, sometimes transient, protein complexes that work in tandem to achieve an adequate native immune response to invading microbes and altered-self, whilst avoiding bystander damage to host cells. The group offers a highly collaborative environment where candidates will have ample opportunity to continue developing their skills to further their careers.

Project one is an ERC funded project on biophysical and structural aspects of the human complement system and will address the role of the various B-cell receptors in the equilibrium between complement attack and defence.

Project two is funded through the Institute for chemical Immunity (NWO-Zwaartekracht) and focusses on the role of tetraspanins in host-cell protection for complement-dependent cytotoxicity (CDC).

Qualifications

We are looking for motivated and skilled candidates that enjoy working in a highly collaborative environment. The projects are quite challenging so we would like for you to be flexible, adaptive and have a keen interest to learn. Furthermore, you have shown to be able to overcome hurdles/challenges in your previous projects.

To excel in this role, you have:

  • a PhD in structural biology, biochemistry, membrane biophysics or a related discipline;
  • a proven interest in structural biology preferably in relation to membrane proteins;
  • experience in reconstituted protein/membrane systems and/or biophysical analysis of protein interactions;
  • experience with spectroscopic methods such as fluorescent scanning-disc confocal microscopy, PALM, or related methods (considered a strong plus).

Offer

  • the chance to become part of a dynamic, multidisciplinary team with a positive and open work ethic;
  • a full-time gross salary depending on previous qualifications and experience ranging between €2,790 and €4,402 per month (scale 10 of the Collective Labour Agreement of Dutch Universities (cao));
  • benefits including 8% holiday bonus and 8.3% end-of-year bonus;
  • a pension scheme, partially paid parental leave, and flexible employment conditions based on the Collective Labour Agreement Dutch Universities.

In addition to the employment conditions laid down in the cao for Dutch Universities, Utrecht University has a number of its own arrangements. For example, there are agreements on professional development, leave arrangements and sports. We also give you the opportunity to expand your terms of employment yourself via the Employment Conditions Selection Model. This is how we like to encourage you to continue to grow.

More information about working at the Faculty of Science can be found here.

About the organization

The Crystal and Structural Chemistry group of Piet Gros shares lab space and facilities with the Cryo-EM group led by Friedrich Förster. Having the two groups together with joint work discussions, coffee breaks etc. creates a stimulating environment where people get the opportunity to get the most out of their projects and themselves.

The groups are part of the Bijvoet Centre for Biomolecular Research at Utrecht University, and offer a collaborative environment and state-of-the-art infrastructure (e.g. cryo-EM, MS, X-ray, NMR, light microscopy (incl. PALM/STORM/SDCM), protein and membrane biochemistry). Cryo-EM microscopes are available at the Utrecht EM-square and national facility NeCEN.

At the Faculty of Science there are 6 departments to make a fundamental connection with: Biology, Chemistry, Information and Computing Sciences, Mathematics, Pharmaceutical Sciences and Physics. Each of these is made up of distinct institutes which work together to focus on answering some of humanity’s most pressing problems. More fundamental still are the individual research groups – the building blocks of our ambitious scientific projects.

Utrecht University is a friendly and ambitious university at the heart of an ancient city. We love to welcome new scientists to our city – a thriving cultural hub that is consistently rated as one of the world’s happiest cities. We are renowned for our innovative interdisciplinary research and our emphasis on inspirational research and excellent education. We are equally well-known for our familiar atmosphere and the can-do mentality of our people. This lively and inspiring academic environment attracts professors, researchers and PhD candidates from all over the globe, making both the University and the Faculty of Science a vibrant international community and wonderfully diverse.

Additional information

Do you have a question about the application procedure? Please send an email to science.recruitment@uu.nl.

Apply

Everyone deserves to feel at home at our university. We welcome employees with a wide variety of backgrounds and perspectives. If you have the expertise and the experience to excel in this role, then simply respond at https://www.uu.nl/organisatie/werken-bij-de-universiteit-utrecht/vacatures/two-postdoctoral-research-positions-in-structural-and-biophysical-characterization-of-the-human

Please enclose:

  • your letter of motivation;
  • your curriculum vitae;
  • the names, telephone numbers, and email addresses of at least two references.

If this specific opportunity isn’t for you, but you know someone else who may be interested, please forward the link to them.

Please note: Due to the current situation regarding the Corona virus (COVID-19) the process of selection and interviews is subject to change. Initial interviews will most likely be conducted online.

Some connections are fundamental – Be one of them

The application deadline is

September 6, 2020

 


[Post Date: July 22, 2020]


Postdoctoral position at The University of Texas Medical Branch (UTMB)

job posting image

Description:

We have a Postdoctoral position opening in the laboratory of Prof. Matthieu Gagnon at The University of Texas Medical Branch (UTMB) at Galveston. The Gagnon lab uses X-ray crystallography and single-particle cryo-EM to study the molecular mechanisms underlying protein synthesis. The ribosome is the focus of our studies. Most of antibiotics used in the clinic inhibit translation and with the rapid rise of antibiotic-resistant pathogens, one of our goals is to decipher the structural bases of drug resistance to ribosome-targeting antibiotics. We are looking for a highly motivated candidate with excellent communication skills. The applicants should have a Ph.D. in biochemistry, chemistry, molecular biology, biophysics, or any other related field. Salary is commensurate with experience and pegged to the current NIH scale.

UTMB has outstanding structural biology facilities. The cryo-EM core now features the latest Titan Krios EM equipped with two direct detector cameras, K3 (Gatan) and Falcon 3 (ThermoFisher). The crystallography core has two X-ray generators for in-house data collection, two temperature-controlled crystallization rooms, and a dedicated Oxford liquid nitrogen cryo-stream to handle ribosome crystals. The Gagnon lab has a dedicated access to storage and GPU computer servers with softwares used in cryo-EM and x-ray crystallography.

Attached is the full description of this position with more information. To apply, please send your CV, cover letter, and contact information for three references directly to Dr. Gagnon. In the cover letter, the applicant should describe how his/her previous research accomplishments and scientific interests fit with the scope of research in the Gagnon laboratory. Further information may be found at the group's web site at https://microbiology.utmb.edu/faculty/matthieu-gagnon. Review of applications begins immediately.

 Download PDF

[Post Date: July 21, 2020]


Postdoctoral Position in CNS antibody-receptor mechanisms and design

View the Job Posting Here

job posting image

Description:

Applications are invited for a postdoctoral (research associate) position (18-months in the first instance) in the laboratory of Dr Paul Miller at the Department of Pharmacology, University of Cambridge, beginning from 1st November 2020.

The project will focus on studying the molecular basis of antibody interactions with membrane proteins involved in blood brain barrier transcytosis. This field of research is vital for the establishment of therapeutic antibody delivery to the central nervous system to treat neurological disorders. This is a great opportunity to nurture skills in cryo-EM and/or X-ray crystallography and execute structure-guided antibody engineering, ideal for follow-on academic and biotechnology careers. The lab utilises automated crystallisation robotics and imaging, and new Arctica and Krios microscopes with Falcon 3/K2/K3 direct detectors. More information about the laboratory is available at https://www.phar.cam.ac.uk/research/miller.

The applicant will hold a PhD with a solid background in structural biology/biophysics/biochemistry. Advantageous experience includes: protein engineering, production and purification; crystallisation and/or cryo-EM and data processing; phage or yeast display platforms; handling membrane proteins. You must be a careful and methodical worker, paying attention to accuracy and ready to take responsibility as part of a team and willing to work in a collaborative environment. You should be self-motivated and able to organise, perform and analyse experiments with minimal instruction.

Application Closing date: 9th August 2020

Project start date: 1st November 2020

For more details and to apply: https://www.jobs.cam.ac.uk/job/26225/


[Post Date: July 21, 2020]


Postdoc Dr. Fang Li's lab at the Department of Veterinary and Biomedical Sciences, University of Minnesota Twin Cities

View the Job Posting Here

job posting image

Description:

A postdoctoral position is available in Dr. Fang Li's lab at the Department of Veterinary and Biomedical Sciences, University of Minnesota Twin Cities. Research involves structural and biochemical studies on the cell entry mechanisms of coronaviruses as well as drug and vaccine developments against coronavirus infections. Requirements include a strong background in molecular biology and protein biochemistry. Expertise in structural biology (cryo-EM or X-ray crystallography) is not required, but will be preferred. Candidates must have completed PhD at the time of the appointment. The initial appointment would be for 1 year, with renewal opportunities for several additional years. Start date is early Fall of 2020, negotiable. Salary is at NIH rates. More information about Dr. Li's lab can be found at http://www.msi.umn.edu/~lifang.


[Post Date: July 17, 2020]


Scientist X-ray Crystallography at ZoBio in Leiden (NL)

job posting image

Description:

ZoBio (www.zobio.com) was founded in 2004 and is located in Leiden, Netherlands. We offer innovative research services in the field of small-molecule drug discovery to the pharmaceutical and biotech industries. Our international team of 26 people covers four fields of expertise: Protein Engineering and Production, Assay Development and Screening, Structural Biology and Medicinal Chemistry.

We are currently looking to strengthen our team with the X-ray crystallographer with a track record in the  protein crystallography and a strong background in the X-ray crystallographic data analysis. In particular, experience in building and refinement of protein – small-molecule complexes would be extremely helpful.

The successful applicant will support our clients’ drug discovery programs by solving ligand-protein structures. You will work with minimal supervision but in a highly collaborative environment within the Structural Biology team and will effectively cooperate on a per-project basis with other research groups at ZoBio. This role requires working on multiple projects simultaneously and in a rapidly evolving environment. Team spirit and excellent organization and communication skills are essential.

RESPONSIBILITIES  

  • High-throughput and -quality structure elucidation and interpretation of biological macromolecules in complexes with small molecules of interest. 
  • Integration and streamlining X-ray crystallography pipelines with the aid of computational structural biology tools to aid the efficient structure elucidation of protein-ligand complexes.
  • Report results to the Head of Crystallography and prepare presentations on the structural data for the project teams and clients.
  • Maintain up-to-date understanding of the state-of-the-field in X-ray crystallography in relation to modern drug discovery challenges. 
  • PhD in relevant field with experience in an industrial or collaborative setting. 
  • Hands-on experience with ligand modelling into electron density maps and macromolecular model building and refinement in the context of Structure-Based Drug Discovery campaigns.
  • Hands-on experience in solving challenging X-ray crystallography cases (e.g. ab initio structure solution).
  • Experience in scripting in Bash/Python and integration of the X-ray crystallography routines. 
  • Experience with computational structural biology tools like ligand docking, virtual screening, molecular dynamics simulation would be considered as an advantage.
  • Able to work in a team in a result-driven, goal-oriented environment.

REQUIREMENTS

It is fully expected that you will become a permanent and integral member of the ZoBio team, after an initial period of 12 months. However, applicants opting for remote and/or flexible working arrangements will also be considered. Applicants at the Senior Scientist or Scientist level will be considered. 

A tailored remuneration package will be proposed in line with individual qualifications and experience. The position is immediately available; the evaluation and assessment of candidates will run until the position is filled but not later than the end of August 2020.  

Please send your CV, motivation letter and names of potential referees at <info@zobio.com> with the subject: “Scientist position in X-ray Crystallography”. 


[Post Date: July 13, 2020]


Crystallographer/Structural Biology Lead, Eternity Bioscience, Cranbury, New Jersey, USA

job posting image

Description:

Essential Job Functions:

  • Produce recombinant proteins in E. coli, insect cell and mammalian cell systems for protein crystallization and biochemical assays.
  • Perform crystallization screening and optimize the conditions of co-crystallization of protein/drug complex to produce high-quality of single crystals for X-ray diffraction.
  • Carry out remote-controlled (and sometimes in-person) collection of X-ray diffraction data and determine high-resolution atomic structures.
  • Deliver and present high-quality and timely structure data to project teams to enable iterative structure-based drug design.
  • Supervise two junior members of the team in protein production and crystallization.
  • Complying fully with the company safety policy when performing experiments
  • Adhering to Lab Notebook guidelines regarding accurate documentation of lab experiments

Job Requirements:

  • Ph.D. in structural biology, biophysics, biochemistry or related discipline with 3-5 years post-doctoral experience.
  • Proficient in recombinant protein production in E. coli, insect cell and mammalian cell systems
  • Skilled in protein engineering for protein crystallization.
  • Expert in protein crystallography, especially in solving crystal structures of ligand-protein complex.
  • Structure-based drug design experience is desirable. Knowledge in structure-based drug design using modern modeling and design tools.
  • Ability to work in a diverse team setting and collaborate effectively with multiple project leaders.
  • Excellent communication, interpersonal and organizational skills. Bilingual in English and Chinese is required.
  • People management experience is not a must.

 Download PDF

[Post Date: July 13, 2020]


Two Postdoc Positions Department of Biological Chemistry and Pharmacology at the Ohio State University

job posting image

Description:

Two postdoctoral fellow positions are immediately available in Tianmin Fu’s laboratory in the Department of Biological Chemistry and Pharmacology at the Ohio State University. The positions are supported by NIH and departmental funding to study molecular mechanism of signaling protein assembly and regulation in inflammation and neurodegenerative diseases. Fu Lab aims to understand the logic of cell signaling across membrane using a multidisciplinary approach including biochemical reconstitution, cryo-electron microscopy, X-ray crystallography, cell biology and pharmacology.

Successful candidates are expected work closely with Dr. Fu in the lab to design and carry out experiments, analyze, organize, and present data in written form and to meetings, and to write papers and grants.

Salaries, stipend, and benefits are highly competitive and commensurate with university policy and NIH guidelines.

The Ohio State University (OSU) is located in Columbus, the capital of Ohio, a fast-growing city in northeast US.

Postdoctoral fellow candidates should hold a Ph.D. degree (or will complete one soon) in structural biology, biochemistry, biophysics, molecular biology, or closely related biological science areas. Prior experiences with membrane protein purification, or cryo-electron microscopy are a plus but not required.

Interested candidates should send a cover letter summarizing their research interests and CV with a publication list and names and contact info of three references (preferably in a single PDF) to fu.978@osu.edu. Informal inquiries are welcome. 


[Post Date: July 9, 2020]


Research Technician EMBL Grenoble, France

View the Job Posting Here

job posting image

Description:

A Research Technician position is available in the High Throughput Crystallization Laboratory at EMBL Grenoble

The HTX lab is one of the largest platforms for automated macromolecular crystallization screening in Europe and is offering services through Instruct and the EC-funded project iNEXT-Discovery. The Marquez Team has developed stream-lined pipelines for fragment screening by X-ray crystallography based on the CrystalDirect technology for automated crystal harvesting and the CRIMS software. These pipelines are applied to study targets of biotechnological and biomedical relevance. The successful candidate will contribute towards the operation of the HTX facility, the development of innovative methods in protein crystallography and will participate in research projects. Under specific circumstances candidates with a PhD and publications who wish to change their career path can also be considered. See details attached.

Applications should be submitted through the www.embl.de/jobs/ portal.

Deadline for applications is August 15th.

 Download PDF

[Post Date: July 7, 2020]


Crystallography, CRELUX, Martinsried, Germany

View the Job Posting Here

job posting image

Description:

A new opportunity has arisen for an experienced Crystallographer to join our growing X-Ray Crystallization Group. This involves the hands on work as well as an up to date knowledge of modern crystallization techniques and standard crystallographic software.

 Download PDF

[Post Date: July 6, 2020]


PostDoctoral Position in Membrane Protein Structural Biology at USC, Los Angeles

job posting image

Description:

The position is available starting January 2021 in the Department of Biological Sciences at the University of Southern California and is initially limited to 2 years, with possible extension.

Our research focuses on the structural biology of important membrane proteins, using single particle cryoEM and X-ray crystallography. We are working in close collaboration with the group of Prof. Vadim Cherezov (USC) on the structural biology of GPCRs. External collaborations include the group of Prof. Dirk Slotboom (Univ. of Groningen) and Prof. K. Chris Garcia (Stanford University).

USC has a suite of research facilities and is in the process of installing a new CryoEM center:

  • Electron microscopy suite: Titan Krios with GIF Quantum energy filter and K3 detector, Glacios with Falcon 4 detector, Talos Arctica with CCD/side entry holder for NS and screening
  • Core facility for insect- and mammalian cell expression
  • High performance computing for data processing/analysis

Qualified candidates must have a Ph.D. degree with a solid background in structural biology and biophysics/biochemistry. Previous work with membrane proteins is a plus. A successful candidate is expected to be highly skilled and self-motivated and is willing to work in a collaborative environment. The Postdoctoral salary depends on qualifications and relevant experiences according to USC standards.

Interested candidates should apply directly with Cornelius Gati at cornelius.gati[at]gmail.com. Please attach a cover letter, Curriculum Vitae, research statement, publication list and a reference letter. The deadline for the application is September 30th 2020.

Current group website: https://gati-lab.slac.stanford.edu/

Recent work from our group includes:

H Shaye, A Ishchenko, JH Lam, GW Han, L Xue, P Rondard, JP Pin, V Katritch, C Gati*, V. Cherezov*

Structural basis of the activation of a metabotropic GABA receptor. Nature. 2020.

S Rempel, C Gati*, M Nijland, C Thangaratnarajah, A Karyolaimos, JW de Gier, A Guskov*, DJ Slotboom*.

A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds. Nature. 2020.


[Post Date: July 2, 2020]


Postdoc position in the Fesik Lab at Vanderbilt University

job posting image

Description:

A postdoc position is available in the laboratory of Dr. Stephen Fesik (https://lab.vanderbilt.edu/fesik-lab/) for a structural biologist with experience in protein NMR or X-ray crystallography.  Responsibilities will include protein expression/purification, conducting fragment screens using NMR, and all aspects of x-ray crystallography, including preparation of protein-inhibitor complexes, crystallization, home/synchrotron data collection, and structure determination. Experience in cloning, site-directed mutagenesis, and the use of robots are highly preferred.  The ideal candidate should be self-motivated and be able to communicate effectively in a highly collaborative environment.


[Post Date: July 1, 2020]


Group Leader – X-ray imaging of biological samples, EMBL Hamburg

View the Job Posting Here

job posting image

Description:

We are seeking to recruit a group leader to develop X-ray imaging applications in the life sciences towards a future user facility.

EMBL Hamburg has pioneered the use of synchrotron radiation in the Life Sciences and has provided service facilities for the use of X-rays in Structural Biology for decades on the DESY campus, Hamburg, Germany. At present, the EMBL Integrated Facility for Structural Biology provides access to structure determination pipelines employing crystallography and/or small-angle X-ray scattering to a large international user community.

EMBL’s future scientific directions, Molecules to Ecosystems, include a vision to advance our understanding of ecosystems at the molecular level, applying expertise in molecular biology to study life in its natural context. New research areas will focus on applying experimental, computational and theoretical approaches to study at multiple levels (molecules, cells, tissues and populations) how organisms interact with each other and respond to environmental change.

Inspired by ground-breaking experiments in the field of X-ray imaging of biological samples, scientists from EMBL have recently started to explore the possibilities of making high-energy X-ray imaging accessible to a wider biological scientific community. Here, we are looking for a candidate with the ability to expand the research and service portfolio of the EMBL Hamburg Unit into X-ray imaging applications. While the current synchrotron PETRA III already provides excellent conditions, the planned upgrade of the on-site synchrotron ring in Hamburg to PETRA IV will open unprecedented new opportunities for X-ray imaging as well.

Your role

  •    Establish an independent and innovative research program towards new approaches in X-ray imaging of biological samples, encompassing experimental, technical or computational developments.
  •    Facilitate experiments in X-ray based and correlative imaging of biological materials, ranging from cells to organoids, organs and organisms, using existing facilities at EMBL and other relevant research infrastructures.
  •    Develop concepts for a future integrated user facility for biological X-ray imaging; participation in the overall planning for facilities at the future PETRA IV synchrotron.

You have

  •    A PhD in a relevant research area.
  •    Profound expertise and track record in X-ray based imaging of biological material, with a particular interest in methodological developments. Additional expertise in correlate imaging approaches would be advantageous.
  •    Strong motivation to work at highly collaborative and multidisciplinary environment of EMBL.
  •    A concise research plan with clearly outlined, original and ambitious research goals.


[Post Date: July 1, 2020]


Research Technician Position, Baylor College of Medicine, Houston, Texas

job posting image

Description:

A RESEARCH TECHNICIAN POSITION is available in the Advanced Technology Core for Macromolecular X-ray Crystallography at Baylor College of Medicine in Houston, TX. The mission of the X-ray Core is to assist basic scientists and clinicians in finding structure solutions in order to develop novel treatments against unmet human diseases. The successful applicant will assist with the robotic crystallization screening and crystal optimization of proteins and protein-drug complexes. This is an entry level staff position that does not require prior experience with crystallization or structure analysis methods. Experience with protein expression and/or purification is an advantage. Salary is commensurate with experience and is in addition to a generous fringe benefit package.

Applicants must have a bachelor's degree in Biochemistry, Chemistry, or in one of the Natural Sciences, and must possess excellent verbal communication and writing skills. To apply, please send a current CV with relevant course work taken, a description of research experiences, and contact information for three referees to Dr. Sukyeong Lee, Associate Professor and Director of the X-ray Core Laboratory.


[Post Date: June 29, 2020]


Scientist Merck KGaA, Darmstadt, Germany

View the Job Posting Here

job posting image

Description:

Your Role:

You will play an important role as scientist in our Healthcare research programs by designing, planning and executing biophysical studies and providing data on molecular interactions to drug discovery projects. Specifically, within our interdisciplinary biophysical and structure biology team, you will design and perform the biophysical characterizations of recombinant target proteins with respect to binding of small molecules or antibodies and in order to enable the generation of protein-ligand complex structures. Your work includes the generation, analysis, interpretation and reporting of experimental data. You will present results to internal and cross functional project teams. Your role will also involve collaboration with various partners across all functions of our research organization. As further important part of your work you will participate in external collaborations for the support of biophysical and structural studies. You will also be involved in the assessment and implementation of novel technologies and in the evaluation of innovative drug targets.

Who You Are:

  • You are holding a Ph.D. in Biophysics, Structural Biology, Biochemistry, Chemical/Biochemical Engineering, Applied Chemistry, or related field, and you have gained substantial practical lab experience in an academic, biopharmaceutical or biotechnological setting.
  • You have expertise in characterizing recombinant proteins by biophysical methods and experiences with the determination of intermolecular binding affinities, thermodynamics and kinetics.
  • You have solid experience in protein structure determination (e.g. by X-ray crystallography or cryo-EM, structure refinement) and computational structure analysis.
  • You have strong oral and written communication skills in English and like to work in cross functional, intercultural teams. You can summarize and present scientific facts in a sound, concise and structured way.
  • You have first experiences in the supervision and/or training of technical assistants or students, and you can routinely set up workplans keeping focus on project objectives and timelines.
  • Research experience in the fields of oncology, immuno-oncology or immunology is advantageous


[Post Date: July 1, 2020]


PostDoc Syun-Ru Yeh Laboratory at Albert Einstein College of Medicine, New York

job posting image

Description:

A NIH-funded postdoctoral position in structural biology is available immediately in the Syun-Ru Yeh Laboratory at Albert Einstein College of Medicine, New York. The postdoctoral fellow will take a lead in elucidating structure and function relationships in two classes of human immunosuppressive proteins, indoleamine 2,3-dioxygenase and tryptophan dioxygenase. The postdoctoral fellow will join an exciting program with a focus on biochemistry and spectroscopy-guided crystallography.  

The successful applicant must have demonstrated experience in chemistry, biochemistry, biophysics or closely related fields. Expertise in spectroscopy, x-ray crystallography and/or computational modeling is a plus. Applicants should provide a CV and a cover letter justifying their suitability and interest in the position. Applicants should also arrange to have three letters of reference sent to Dr. Syun-Ru Yeh (syun-ru.yeh@einsteinmed.org).

Albert Einstein College of Medicine is located in New York in a scenic Bronx campus that includes comfortable, affordable housing in an area rich with recreation and entertainment. The scientific environment provides outstanding research training opportunities.


[Post Date: June 29, 2020]


Crystallographer position at Eternity Bioscience

job posting image

Description:

Eternity Bioscience Inc. in Cranbury, New Jersey, USA, is a discovery research subsidiary of Jiangsu Hengrui Medicine Co., Ltd. of China. Our mission is to deliver high quality and translational preclinical drug candidates for critical medical needs. The company is seeking a well-qualified structural biologist to join its drug discovery team. The successful candidate will be proficient in working independently and collaboratively as part of multidisciplinary project teams and have the capacity to quickly adapt to project priority changes.

Job Description:

1.   Perform necessary duties including gene construct design, high throughput recombinant protein expression, purification and characterization, target/drug complex crystallization screening, remote-controlled (and occasional in-person) collection of X-ray diffraction data, and high-resolution atomic structure determination.

2.   Deliver high-quality and timely structure data to project teams to enable iterative structure-based drug design.

3.   Present the work clearly in internal project meetings.

Basic Requirements:

1.   PhD degree in structural biology, with drug discovery research experience desirable.

2.   Proficiency in the workflow from gene construct design to atomic structure determination.

3.   Knowledge in structure-based drug design using modern modeling and design tools.

4.   Ability to work in a diverse team setting and collaborate effectively on complex projects.

5.   Excellent communication, interpersonal, and organizational skills. Bilingual in English and Mandarin is a plus.

Prospective candidates are encouraged to visit the following link for more information: www.eternitybioscience.com.

As a well-funded biotech company, we pay highly competitive salaries and a comprehensive benefits package. Interested applicants are encouraged to submit their CV to the following email address: zhuangl@eternitybioscience.com.


[Post Date: June 29, 2020]


Senior Scientist I, Protein X-ray Crystallography

View the Job Posting Here

job posting image

Description:

Company overview:

AbbVie (NYSE:ABBV) is a global, research-driven biopharmaceutical company committed to developing innovative advanced therapies for some of the world’s most complex and critical conditions. The company’s mission is to use its expertise, dedicated people and unique approach to innovation to markedly improve treatments across four primary therapeutic areas: immunology, oncology, virology and neuroscience. In more than 75 countries, AbbVie employees are working every day to advance health solutions for people around the world.

Job description:

The Protein Crystallography Group at AbbVie Headquarters in Lake County, Illinois is seeking a highly motivated scientist to join our Structure-Based Drug Discovery team. The ideal candidate should have extensive hands-on experience in modern X-ray Crystallography techniques and computational methods of molecular structure analysis. As part of multidisciplinary teams, the Scientist will utilize fragment-based strategies to identify ligands and provide insight to advance drug discovery targets through structure-based design. The successful candidate will contribute to drug discovery projects across the portfolio of AbbVie interests that also include therapeutic antibodies and novel biologics.


[Post Date: June 25, 2020]


Postdoc Positions in Du and Lü labs at Van Andel Institute

View the Job Posting Here

job posting image

Description:

A few joint postdoctoral positions are available in the laboratories of Dr. Juan Du and Dr. Wei Lü at Van Andel Institute. The Du lab and Lü lab are interested in understanding how human body senses external stimuli, conveys the signals to the brain and generates responses via ion channels. To address these fundamental questions, our lab uses a diverse set of approaches to study the structure and function of these ion channels by combining single-particle cryo-EM, patch-clamp electrophysiology, X-ray crystallography, and other functional approaches. The cryo-EM facility at Van Andel Institute host a Titan Krios equipped with a K3 camera, and a Talos Arctica equipped with a K2 camera.

Experience in structural biology, membrane protein biochemistry, or ion channel electrophysiology are preferred, but not required. Interested individuals should send a CV and a cover letter to Wei Lü (wei.lu@vai.org). For more information, please visit our lab website https://dululabs.com/


[Post Date: June 22, 2020]


Post-doctoral position in Structural Biology - Paris-Saclay University, INRAE

job posting image

Description:

A post-doctoral position in structural biology is available at the ChemSyBio team (Paris-Saclay University, INRAE, Micalis) headed by Dr Olivier Berteau. The project involves structure determination of novel metalloenzymes catalyzing post-translational modifications in peptides (ribosomally synthesized and post-translationally modified peptides, RiPPs) in order to decipher their mechanisms and enzyme substrate interactions.


We are seeking for a highly motivated post-doctoral fellow with a proven experience in structural biology. The candidate should have a PhD in structural biology and a good knowledge of crystallography software. He/She should have an experience in protein expression, purification, crystallization and the ability to work in a multi-disciplinary environment. Skills in molecular biology and physico-chemical techniques would be an asset.


Recent publications from our team include: Balty C et al. 2019 JBC; 294(40):14512-14525; Parent A. et al. 2018 J Am Chem Soc. ; 140(7):2469-2477.; Benjdia A et al. 2017 Nature Chemistry ; 9(7):698-707; Parent A. et al. 2016 J Am Chem Soc.; 138(48):15515-15518; Benjdia A. et al.2016 Chem Commun.; 52(37):6249-52; Benjdia A. et al. 2015 Nat Commun; 6:8377.


Access to state-of-the-art research facilities will be provided. Our laboratory (Micalis institute) is part of Paris-Saclay University and located near Paris. The position is offered for two years and the salary will be commensurate with experience.
Applications (including CV, description of your research activity indicating your relevant skills and reference letters) should be sent to Dr Alhosna Benjdia (alhosna.benjdia@inrae.fr) and Dr Olivier Berteau (olivier.berteau@inrae.fr).

 Download PDF

[Post Date: June 16, 2020]


Senior Crystallography Scientist Abingdon Evotec

View the Job Posting Here

job posting image

Description:

Evotec (UK) Ltd is currently seeking to add to its Structural Biology Department. The group works closely with our Discovery Chemistry Department and with clients to develop novel small molecule drugs. It is at the forefront of new science and technology, and is seeking to expand as business needs grow.


[Post Date: April 23, 2020]