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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Beamline scientist BioMAX (Teamleader FragMAX)

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Description:

BioMAX is the first operational beamline for macromolecular crystallography at MAX IV and runs within the MAX IV user program for the last 3 years. The beamline is a state-of-the-art beamline geared towards high-throughput protein crystallography with high performance x-ray optics and control systems, goniometry, x-ray detectors and a cryogenic sample changer (see also: http://www.maxiv.se/biomax). The beamline is able to provide remote access to the users. As part of the user facilities available at BioMAX, we are developing the FragMAX platform, with the aim to develop and operate a crystallographic fragment screening facility at MAX IV.

The beamline is operated by the international and interdisciplinary BioMAX team, which is part of the MX-group. Within the MX group we are also constructing and developing MicroMAX, a serial crystallography beamline for studying protein dynamics.

We are now looking for a beam line scientist who will lead the FragMAX project team. We think you enjoy working in an international and creative environment. You will join our team working at the BioMAX beamline to further develop the FragMAX screening platform. This includes constant development of relevant processes to carry out fragment screening at all levels of our support chain, support of users during screening experiments and standard beamline support, collaborations with external partners such as the LP3 laboratory, industrial partners as well as other international collaborators and future FragMAX user communities.

You are expected to work both independently and in close collaboration with the entire BioMAX team and with academic and industrial collaboration partners. User support will be an important part of the activity. The MX environment will provide opportunities for collaborative work at the frontiers of the field structural biology.


[Post Date: May 27, 2020]


Two Post Doc positions at Sanofi R&D in Paris, France

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Description:

We are looking to fill two PostDoc positions in our Bio Structure and Biophysics department at Sanofi R&D in Vitry-sur-Seine, near Paris in France.  These are great opportunities for self-motivated and talented structural biologists to undertake protein biochemistry, biophysical and cryoEM studies on various medically relevant protein complexes.  To learn more about the position and to apply please follow the two links.

https://sanofi.wd3.myworkdayjobs.com/SanofiCareers/job/Vitry-sur-Seine/Scientist--Post-Doc-_R2555017

https://sanofi.wd3.myworkdayjobs.com/SanofiCareers/job/Vitry-sur-Seine/Scientist--Post-Doc-_R2553869

Closing date for the applications: end of June 2020.


[Post Date: May 27, 2020]


Postdoctoral opportunities in structural biology of parasite signal transduction

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Description:

The Reese lab at UT Southwestern Medical Center is recruiting highly motivated postdocs to join our team studying the molecular mechanisms of signaling at the Toxoplasma-host pathogen interface. We take an interdisciplinary approach and combine methods from molecular genetics, cell biology, biochemical and biophysics to deeply interrogate Toxoplasma biology.

Current projects include:

  • Combining cell biology with innovative cryoET and XL-MS methods to determine structures of parasite complexes required for the biogenesis of the Toxoplasma parasitophorous vacuole
  • Cellular and biophysical studies (cryoET, cryoEM, X-ray crystallography) of signaling complexes essential to parasite invasion of mammalian cel
  • Structure-based drug discovery for inhibitors of kinases essential to the apicomplexan lytic cycle (that is, the parasites that cause the human diseases toxoplasmosis, malaria, and cryptosporidiosis).

This would be a great opportunity for someone with graduate training in molecular cellular biology or genetics to learn to integrate biophysics and biochemistry into their research. Those with strong biophysics training who would like to dive into work on an atypical model organism with strong medical relevance are also encouraged to apply. Applicants should hold a recent Ph.D. (or be within a year of receiving their Ph.D.). If interested, please send a CV with cover letter and contact information for 2-3 references to michael.reese@utsouthwestern.edu.

Members of the Reese lab have full access to outstanding shared facilities as UT Southwestern, including high-field NMR, X-ray crystallography (with regular synchotron access), and world-class cryoEM. UT Southwestern is highly collaborative institution located in the heart of Dallas, TX. Dallas is a diverse city that is fun and affordable, with great food and arts.

As an equal opportunity employer, UT Southwestern’s employment decisions are made without consideration of race, color, national origin, religion, sex, age, veteran status, or disability.​​


[Post Date: May 19, 2020]


Postdoctoral Research Associate Brookhaven National Laboratory

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Description:

The Biology Department has an opening for a Postdoctoral Research Associate to complement the efforts of the Quantitative Plant Science Initiative (QPSI) in the Biology Department of Brookhaven National Laboratory. We invite talented candidates to apply for this position to work on plant membrane proteins in particular metal transporters. The ideal candidate will carry out structural and functional investigation of metal transporters involved in nutrient uptake, stress responses, photosynthesis, and metal homeostasis. Structural and mechanistic understanding that underlies the physiological role of these membrane proteins will expand our knowledge base with which to manipulate bioenergy crops for improved adaptation to growth on marginal land. The successful candidate will also be expected to assist with developing a high-throughput platform for membrane protein production and characterization at small scale. An initial two-year appointment may be renewed for up to five years contingent on performance and availability of funds.


[Post Date: May 19, 2020]


Senior Crystallography Scientist Abingdon Evotec

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Description:

Evotec (UK) Ltd is currently seeking to add to its Structural Biology Department. The group works closely with our Discovery Chemistry Department and with clients to develop novel small molecule drugs. It is at the forefront of new science and technology, and is seeking to expand as business needs grow.


[Post Date: April 23, 2020]


Postdoctoral Research Associate (Structural Biology, X-ray Crystallography) The Hevener laboratory at the University of Tennessee Health Science Center

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Description:

The Hevener laboratory at the University of Tennessee Health Science Center invites applications from highly motivated and self-sufficient scientists for a full-time Postdoctoral Research Associate to support a multi-year, federally funded research project. The successful candidate must possess a Ph.D. in protein biochemistry, structural biology or a closely related discipline and have expertise in macromolecular x-ray crystallography. Additional skills in protein expression/purification and molecular cloning are desirable. Candidates must also possess strong oral and written communication skills, the ability to work both independently and as the member of a team, and a record of first author publications in structural biology. Learning opportunities for the successful candidate include training in enzymology, HTS assay design, virtual screening, and computer-aided methods in drug development.


The Hevener Laboratory at UTHSC focuses on the validation and characterization of novel infectious disease drug targets using both experimental and computational methods. This project focuses on a target in the bacterial fatty acid synthesis pathway and will involve x-ray co-crystallography and structure-guided lead optimization. UTHSC offers postdoctoral researchers a competitive salary and full benefits package. Negotiable release time will be permitted for the development of independent projects.


Application Process: For full consideration, please apply through https://uthsc.edu/hr/employment/ Post-Doctoral Fellow Positions #2000000IX, and submit the following items: a cover letter; full curriculum vitae; list of three references; and a summary of research experience. Review of applications begins on arrival and the search will remain open until the position is filled.


The University of Tennessee is an EEO/AA/Title VI/Title IX/Section 504/ADA/ADEA/V institution in the provision of its education and employment programs and services.

 Download PDF

[Post Date: May 11, 2020]


Postdoc University of Alberta

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Description:

Applications are invited for a postdoctoral position to work on crystallography of proteases. Experience in crystallography is preferred. In addition, the successful candidate should be well versed in one or more of the following areas: molecular biology, protein purification, and membrane protein biochemistry. The candidate must be within five years of attaining a PhD degree.

This is an opportunity to join a lab experienced in the expression and crystallization of various enzymes, including soluble coronavirus proteases (https://www.biorxiv.org/content/10.1101/2020.05.03.073080v2) and membrane proteins (See PNAS (2007) 104(3):750-4, and Science, (2003)301:616-620),( http://www2.biochem.ualberta.ca/LemieuxLab/).  The University of Alberta, located in Edmonton, Alberta (Canada), is home to a large and interactive community of biomedical scientists, and facilities for structural biology are excellent. Our department provides interaction with numerous crystallographers. The Canadian Light Source (CLS) synchrotron facility is located a short drive away. In addition, the membrane protein research group provides a dedicated forum for membrane protein research at the University of Alberta (http://www.mpdrg.com).

Edmonton, having a population of over 1 million, offers a cosmopolitan environment with world-class performing arts, sports, culinary and recreational opportunities.  In addition, the city’s proximity to the Rocky Mountains including the towns of Jasper and Banff is an additional bonus.

Salary is commensurate with training and experience at the CIHR standard rates. A medical and dental benefit package is included with salary. The University of Alberta hires on the basis of merit. We are committed to the principle of equity in employment. We welcome diversity and encourage applications from all qualified women and men, including persons with disabilities, members of visible minorities, and Aboriginal persons. The records arising from this competition will be managed in accordance with provisions of the Alberta Freedom of Information and Protection of Privacy Act (FOIPP).

Please direct CV, statement of interests including structures previously solved, and a list of three references to Dr. M. Joanne Lemieux at the following email address: joanne.lemieux@ualberta.cawith the subject header: PDF application.


[Post Date: May 8, 2020]


Postdoctoral Research Fellow position Structural Biology of Functional RNAs and RNA/protein Complexes

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Description:

A postdoctoral training position is available in the laboratory of Yunsun Nam, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center to study the mechanisms of post-transcriptional gene regulation. Our laboratory has several exciting projects related to how RNA structure changes the destiny of an RNA by altering its function and specific interactions with proteins. The goal is to determine how macromolecular recognition and enzymatic regulation are accomplished, using biochemistry, structural biology, and cell biology. The functional noncoding RNAs and RNA/protein complexes we study are relevant for normal development as well as diseases such as cancer, making our mechanistic work also valuable for therapeutics research. Postdoctoral scholars will have many opportunities to learn the newest methods in protein and nucleic acid biochemistry and biophysics, in addition to working in an exciting, fast-evolving field in biomedical sciences. We use various approaches, including X-ray crystallography, NMR spectroscopy, cryo-electron microscopy (cryo-EM), molecular biology, nucleic acid and protein biochemistry, genomics with next-generation sequencing, drug discovery, and mammalian cell-based studies. The postdoctoral fellow will have ready access to the top of the line equipment and resources necessary for the above approaches. Information on the UT Southwestern postdoctoral training program and benefits can be found in the Postdoc Handbook.

Candidates must hold a Ph.D. and/or M.D. degree. Experience in biochemistry (protein or nucleic acids), cell biology, and/or structural biology leading to publication in peer-reviewed journals is recommended.

Interested individuals should send a CV, statement of interests, and a list of three references as a single pdf file to:

Yunsun Nam, Ph.D.

Yunsun.Nam@utsouthwestern.edu

Lab Website: www.ynamlab.org

UT Southwestern Medical Center is an Affirmative Action/Equal Opportunity Employer. 


[Post Date: May 8, 2020]


Researcher Laboratory of Protein Structure

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Description:

Laboratory of Protein Structure at the International Institute of Molecular and Cell Biology in Warsaw (http://bit.ly/nowotny-lab) seeks a researcher (full time position) to work in a large multinational consortium project that aims at the development of antiviral substances for treatment of COVID-19. The position is available in frame of EXSCALATE4CoV project funded by the European Commission (www.iimcb.gov.pl/en/press-office/news/news/1112-developing-sars-cov-2-antiviral-drugs). The person in this position will be responsible for the determination of crystal and cryo-EM structures of viral protein in complex with inhibitors (potential antiviral drugs).


[Post Date: May 7, 2020]


Project Scientist - Sample Delivery

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Description:

 

SLAC National Accelerator Laboratory (SLAC) is one of the world’s premier research laboratories, providing an internationally leading capability in the form of its accelerator based light sources and its science programs. The Linac Coherent Light Source (LCLS), a directorate of SLAC and the world’s first hard x-ray free electron laser, seeks a Research Associate with a background in sample introduction for serial data collection to join the Sample Environment and Delivery group within the LCLS Hard X-Ray department. Members of this department are responsible for developing new instrumentation and methods as well as performing innovative ultrafast experiments using hard x-ray beams from LCLS. The SED group specifically focuses on sample preparation, characterization and delivery.

 

Please Note – due to COVID-19 related curtailment of on-site activities, the job duties for this position will be required to be performed from home until full site-access is restored.

 

In this position, you will primarily support the development and integration of methods for sample introduction of biological samples at LCLS and will also support the user experiment program. You will participate in and contribute to efforts involving the characterization and testing of sample introduction methods for solutions and suspensions as well as help to automate sample introduction at the LCLS beam lines. You will have the opportunity to collaborate with researchers at SLAC and Stanford University working on simulations and theoretical frameworks of the underlying physics. The successful candidate should be curious, motivated and self-driven.

 

Note: The position is a 2 year fixed term with the possibility of renewal. Assignment duration is contingent upon project needs and funding.

 

To be successful in this position you will bring:

 

  • A Ph.D. (or its equivalent in research skill and subject knowledge) in physics, engineering, biochemistry, or related field in demonstrated coursework and research experience with sample preparation, characterization and delivery. (Candidates currently pursuing a PhD or recently graduated with relevant post-graduate research background are encouraged to apply)
  • Experience with sample introduction for serial data collection at x-ray sources.
  • Demonstrated experience as evidenced by a publication record commensurate with level of work experience.
  • Ability to carry out independent research.
  • Strong analytical and experimental skills.
  • Effective written and verbal communication skills.
  • Ability to work and communicate effectively with a diverse population.

 

In addition, preferred requirements and experience include:

 

  • User facility operations and research.
  • X-ray crystallography, especially serial methods.
  • X-ray scattering techniques.
  • Script writing and data analysis using Python
  • Experience in automation

 

SLAC employee competencies:

 

  • Effective Decisions: Uses job knowledge and solid judgment to make quality decisions in a timely manner.
  • Self-Development: Pursues a variety of venues and opportunities to continue learning and developing.
  • Dependability: Can be counted on to deliver results with a sense of personal responsibility for expected outcomes.
  • Initiative: Pursues work and interactions proactively with optimism, positive energy, and motivation to move things forward.
  • Adaptability: Flexes as needed when change occurs, maintains an open outlook while adjusting and accommodating changes.
  • Communication: Ensures effective information flow to various audiences and creates and delivers clear, appropriate written, spoken, presented messages.
  • Relationships: Builds relationships to foster trust, collaboration, and a positive climate to achieve common goals.

 

Physical requirements and working conditions:

 

  • Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of the job. May work extended hours during peak business cycles. The ability to travel to synchrotron and XFEL facilities around the world to perform experiments

 

Work standards:

 

  • Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
  • Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for environment, safety and security; communicates related concerns; uses and promotes safe behaviors based on training and lessons learned.  Meets the applicable roles and responsibilities as described in the ESH Manual, Chapter 1—General Policy and Responsibilities:  http://www-group.slac.stanford.edu/esh/eshmanual/pdfs/ESHch01.pdf
  • Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide,  http://adminguide.stanford.edu

 

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

 

  • Classification Title: Project Scientist
  • Job code: 0112
  • Duration: Fixed Term - 2 years

 


[Post Date: May 7, 2020]


Postdoc in the group of Prof. Francis Tsai at Baylor College of Medicine in Houston, Texas, USA

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Description:

A postdoctoral fellowship position is available in the group of Prof. Francis Tsai at Baylor College of Medicine in Houston, TX. The Tsai lab uses X-ray crystallography and single-particle cryoEM to determine 3D structures of protein machines to provide new structural and mechanistic insights (PNAS, 2016; Cell Rep.2019; J. Mol. Biol., 2019; eLife2020). Applicants must be highly-motivated and possess demonstrated experience with methods used to express and purify proteins. Prior experience in enzymology or working with model organisms (bacteria, yeast, worms, etc.) is an advantage. Applicants should possess excellent communication skills and have a Ph.D. in Biochemistry, Molecular Biology, or any other relevant field. Salary is commensurate with experience and pegged to the current NIH scale.

To apply, please send your CV, a description of research experience, and contact information for three referees to ftsai@bcm.edu. Further information may be found at the group's web site at https://www.bcm.edu/people/view/francis-tsai-d-phil/b17c0a77-ffed-11e2-be68-080027880ca6


[Post Date: May 4, 2020]


Sanofi Postdoctoral Fellowship: Computational Scientist for Antibody Engineering (Framingham, MA)

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Description:

Job Description:

We are seeking a highly talented Computational Scientist for a postdoctoral position to join the Protein Engineering group within Sanofi US Biologics Research Department.  We use leading-edge structural biology and computational modeling tools to support different biologics project needs from Sanofi’s multi-targeting, multi-modality research pipeline. Our team has a great track record of patents and publications, including Science, Nature Cancer, and Nature Communications, in the area of biologics characterization, antibody engineering and multi-specific antibodies. This postdoc project will focus on developing a machine learning approach to predict epitope-paratope, given any antibody-antigen pair, by combining in-depth understanding of structure biology, antibody engineering, and large datasets both internally and externally. The successful candidate will be with Ph. D. degree in related area and has an advanced understanding and practical experience with developing and applying complex machine learning solutions for structural biology data.

Responsibilities:

  • Interact closely and be part of interdisciplinary antibody engineering teams to drive effective decision-making by mining and developing predictive models
  • Extract new knowledge and disruptive insights from the large and rich body of data collected internally and externally.
  • Develop and implement methods for extracting patterns and correlations from diversified data sources using cutting edge computation and data science toolkits.
  • Keep ahead of scientific literature and interact with internal and external scientists to integrate novel data science technologies

Basic qualifications:

  • Ph. D. in data science, artificial intelligence, machine learning, deep learning, computer sciences, bioinformatics, mathematics, computational biology, or related field with 0-3 years of academic or industrial experience.
  • In-depth experience with modern and classical methods used in artificial intelligence.
  • Fluent programming with Python (or R), preferably in Linux and high-performance computing environments
  • Excellent written and oral communication skills
  • Passion to collaborate with others, self-development with a focus on scientific know-how, and sharing knowledge externally as publications or conference presentations.
  • Must have the authorization to work in the United States; no visa sponsorship will be provided.

Preferred qualifications:

  • Working knowledge of structural biology and antibody discovery is a plus
  • Hands on experience with data analysis software such as Spotfire or similar
  • Familiar with the foundational concepts in molecular biology and biochemistry

Term of employment: 2-3 years

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

#GD-SA

#LI-SA

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.


[Post Date: April 29, 2020]


Postdoc Position Available at Rice University Houston

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Description:

A postdoctoral position is available in Dr. Yang Gao’s lab (http://yanggaolab.blogs.rice.edu/) at Rice University, Houston. The Gao lab utilizes structural biology techniques to investigate the molecular mechanisms of DNA replication and repair. We employ cryo-electron microscopy, x-ray crystallography, and various biochemical and biophysical approaches to characterize how enzymes and motors work together to accomplish these elaborate processes (see Gao’s recent publications https://science.sciencemag.org/content/352/6291/1334.short, https://science.sciencemag.org/content/363/6429/eaav7003.abstract and https://scholar.google.com/citations?user=y296jScAAAAJ&hl=en). The postdoctoral fellow will investigate structures and mechanisms of important helicases in genome replication and repair, with cryo-electron microscopy as the major technique.

Applicants should have a Ph. D. degree in biochemistry, structural biology or related field. Experiences with mammalian protein expression, cryo-electron microscopy, and computational biophysics are preferred but not required. Please contact Yang at yg60@rice.edu for more detail.


[Post Date: April 29, 2020]


Research Lab Technician (IV) McMaster University

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Description:

A full-time research lab technician position is available at the Michael DeGroote Institute for Infectious Disease Research at McMaster University, in Ontario, Canada.  The position will be shared between the McMaster Macromolecular Crystallography Facility and the Centre for Microbial Chemical Biology. Duties will include oversight of an X-ray diffractometer with single-crystal and SAXS capabilities, a crystallography liquid handler and imaging robotics, and several protein purification systems. The candidate will be expected to oversee the maintenance of this equipment, facilitate the training of new users, and may participate in the determination of protein structures. Experience with the collection and interpretation of X-ray diffraction data is desired. Strong communication skills and mechanical aptitude with laboratory equipment is a must.

The position is initially for a one year probationary period; however, funding is in place for a long term position should the candidate meet all expectations. McMaster University offers a generous benefits package to its employees (drug plan, dental coverage and pension) and being located at the intersection of the cities of Dundas, Ancaster and Hamilton, is located in a relatively affordable region of Ontario. Nearby housing is available in rural, suburban and urban neighbourhoods, all of which have a minimal commute time to the university.

A link to the job posting can be found at https://tinyurl.com/mpoolzg . Look for posting 31784 and apply directly there.


[Post Date: April 29, 2020]


Postdoctoral Associate - Gonen Lab - Biochemistry

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Description:

We currently have an opening for a Postdoctoral Associate in the laboratory of Dr. Tamir Gonen at the University of California, Los Angeles (UCLA). The Gonen lab works toward understanding how membrane proteins help cells maintain homeostasis. To that end, they study channels, transporters, and receptors structurally and functionally. There is an exciting opportunity for a Postdoctoral Associate to join the team in the lab to engage in projects in membrane biophysics and biochemistry. This position will require a driven, creative individual who has membrane protein purification and expression experience, is willing to tackle novel challenges, and continually work towards process improvement. Ideal candidates will also be incredibly organized, personable, able to work independently, and have a strong desire to work collaboratively in the lab.


[Post Date: April 27, 2020]


Scientist at Beamline P11

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Description:

We would like to draw your attention to the following open position: Scientist at Beamline P11, DESY, Hamburg

DESY is one of the world’s leading research centres for photon science, particle and astroparticle physics as well as accelerator physics. More than 2400 employees work at our two locations Hamburg and Zeuthen in science, technology and administration.

With the storage ring PETRA III and the Free-Electron-Laser (FLASH), DESY offers a unique combination of photon sources to the scientific community. PETRA III, one of the most brilliant hard X-ray facilities worldwide, currently provides 23 undulator beamlines for experiments utilizing the extreme source brilliance. The Bio-Diffraction Beamline P11 provides high flux and versatile experimental setup for structure determination of biological samples. We are seeking a highly motivated scientist to join our beamline team.

The position:

User support and commissioning work at beamline P11 Beamline instrumentation and/or methodological develompment, e.g. in field of automation of data collection pipelines Work in an international, interdisciplinary team in a close contact with the user community Develop and pursue research projects in the field of macromolecular crystallography.

Requirements:

PhD in biochemistry, chemistry or a related field Experience in protein crystallography and structure detemination using synchrotron radiation, supported by the publication record Working experience in instrumentation of macromolecular crystallography beamlines Teamwork abilities Excellent oral and written communication skills in English Working knowledge of Linux environment and experience in programming languages such as Python is an advantage.


[Post Date: April 24, 2020]


Beamline scientist BioMAX (Teamleader FragMAX)

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Description:

BioMAX is the first operational beamline for macromolecular crystallography at MAX IV and runs within the MAX IV user program for the last 3 years. The beamline is a state-of-the-art beamline geared towards high-throughput protein crystallography with high performance x-ray optics and control systems, goniometry, x-ray detectors and a cryogenic sample changer (see also: http://www.maxiv.se/biomax). The beamline is able to provide remote access to the users. As part of the user facilities available at BioMAX, we are developing the FragMAX platform, with the aim to develop and operate a crystallographic fragment screening facility at MAX IV.

The beamline is operated by the international and interdisciplinary BioMAX team, which is part of the MX-group. Within the MX group we are also constructing and developing MicroMAX, a serial crystallography beamline for studying protein dynamics.

We are now looking for a beam line scientist who will lead the FragMAX project team. We think you enjoy working in an international and creative environment. You will join our team working at the BioMAX beamline to further develop the FragMAX screening platform. This includes constant development of relevant processes to carry out fragment screening at all levels of our support chain, support of users during screening experiments and standard beamline support, collaborations with external partners such as the LP3 laboratory, industrial partners as well as other international collaborators and future FragMAX user communities.

You are expected to work both independently and in close collaboration with the entire BioMAX team and with academic and industrial collaboration partners. User support will be an important part of the activity. The MX environment will provide opportunities for collaborative work at the frontiers of the field structural biology.


[Post Date: April 23, 2020]


Scientist, Protein and Structural Sciences

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Description:

Epizyme, Inc. is a fully integrated commercial-stage biopharmaceutical company committed to its mission of rewriting treatment for cancer and other serious diseases through novel epigenetic medicines. In addition to an active research and discovery pipeline, Epizyme has one U.S. FDA approved product, TAZVERIK™ (tazemetostat), for the treatment of patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma who are not eligible for complete resection. This indication is approved under accelerated approval based on overall response rate and duration of responseContinued approval for this indication is contingent upon verification and description of clinical benefit in an ongoing confirmatory trial. The company is also exploring the treatment potential of tazemetostat in investigational clinical trials in other solid tumors and hematological malignancies, as a monotherapy and combination therapy in both relapsed and front-line disease settings. By focusing on the genetic drivers of disease, Epizyme seeks to match medicines with the patients who need them. For more information, visit www.epizyme.com.

Epizyme has assembled a world-class team with a passion for scientific innovation and a commitment to developing novel epigenetic therapies.  Join a dynamic, diverse and fun work environment consistent with Epizyme’s cultural attributes for success: camaraderie, collaboration, disciplined, innovative, openness, patient-focused and resilient. 

SUMMARY

The Scientist, Protein and Structural Sciences position will be responsible for the delivery of proteins to support biochemical and biophysics assays, and structural research workflows. The candidate will leverage protein ligand co-structure information to accelerate drug discovery projects.

RESPONSIBILITIES

  • Maintain and manage relationships with CRO providers of protein production and structural biology resources to efficiently accomplish project goals on time and budget.
  • Responsible for construct design, expression, purification, characterization and documentation of proteins for use in assay and biophysical experiments.
  • Ensure the delivery of high quality protein structural information through efficient recombinant protein design, protein expression, protein purification, crystallization, co-crystal structure determination, data collection and refinement.
  • Effectively interface with biochemists, biologists, structural biologists, medicinal and computational chemists to drive project progression.
  • Stay scientifically current, in order to proactively identify, recommend and implement new technologies and capabilities.
  • Make complex judgments, develop innovative solutions, and apply a comprehensive cross-functional and industry understanding to all project support.

REQUIREMENTS

  • A PhD (or equivalent experience) with 3+ years of relevant experience in protein production and protein crystallography.
  • A demonstrated understanding of molecular biology, protein expression, protein biochemistry, and protein crystallography.
  • Ability to work independently and ability to interact with a multidisciplinary team of medicinal chemists, biochemists, biologists, and external collaborators.
  • Strong organizational skills, ability to work on multiple projects simultaneously, superior communication skills (both written and oral), and attention to detail are an absolute must.
  • Experience with expression and purification of multi domain complexes and/or fragment crystallography is a plus.
  • Excellent understanding of protein engineering and biophysics and its application alongside structure delivery and exploitation in drug discovery projects is a plus.

Applicants should forward their CV’s to Steve Downing at sdowning@epizyme.com

Epizyme, Inc. is a vibrant, entrepreneurial EEO employer committed to a diverse and dynamic workplace.


[Post Date: April 17, 2020]


Multiple Postdoctoral Fellowships at the Multiscale Research Institute for Complex Systems, Fudan University, Shanghai, China

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Description:

The Multiscale Research Institute for Complex Systems (MRICS) at Fudan University is located at the Zhangjiang Campus of Fudan University and is supported by the Shanghai High-level Talents Program.  MRICS is strongly committed to the development of novel and effective multi-scale imaging technology that spans microscopic molecular structures all the way to macroscopic medical imaging, with the aim to provide unprecedented spatial and temporal insights into the structures and functions of living beings at all levels (molecules, cells, tissues, organs and even whole organisms). Specifically for structural biology, MRICS is equipped with a state-of-the-art cryo-EM facility that includes FEI Titan Krios with Volta phase plate, Glacios, Talos and Aquilos. MRICS is also located next to Shanghai Synchrotron Radiation Facility for X-ray crystallography.

Our team includes Nobel laureate and international leading interdisciplinary experts.   

We have new openings for multiple postdoctoral fellows in structural biology who will mainly study important biological systems by means of cryo-electron microscopy including single-particle and tomography.

Requirements:

The applicants should have a recent Ph.D. degree (within two years of graduation) or will have a Ph.D. degree within the next six months in biology or chemistry-related fields, be devoted to excellence in scientific research, have strong sense of responsibility, and be highly motivated and hardworking.  For these positions, extensive experience in protein expression and purification is a must, while prior experience in X-ray crystallography or cryo-EM is a plus, but is not required. 

Compensation:

1)    We offer internationally competitive salary, fringe benefits and yearly bonus. The level of salary will be determined according to the applicant's experience and qualification; 

2)    Low-rent housing on campus is provided; 

3)    There are ample opportunities to collaborate with world-renown laboratories;

4)    We provide support for applying for funding opportunities whenever applicable. 

Shanghai is one of the most cosmopolitan cities in China with strong economy and vibrant scientific community.

For interested applicants, please submit postdoctoral application packages (a combined pdf) including resumes, representative publications, phone numbers and email addresses of three academic referees to mrics_fd@fudan.edu.cn.

We look forward to your joining of our first-class team!


[Post Date: April 13, 2020]


Sr. Scientist, Structural Biologist (X-ray crystallography, Cryo EM), Merck

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Description:

Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

This position within the Computational and Structural Sciences Department at Our Company's Research Laboratories (South San Francisco, CA USA) will support drug discovery through the use of atomic resolution single-particle cryo-EM and x-ray diffraction to determine the structure of therapeutically important targets. The successful candidate will join our growing structural biology team and be responsible for all aspects of the structural biology process, from sample preparation and data collection through data processing and structure determination and will work in collaboration with medicinal and computational chemists. The successful candidate will work closely with molecular biologists, biochemists, and biophysicists for sample optimization.   

Productive and collaborative interactions with other members of the global, cross-functional department are required. There is an expectation for periodic travel to other locations. Cooperative and collaborative use of internal expertise and resources will be essential to success. The position requires active interaction with the external scientific community to continually improve scientific understanding, including presentations at national or international meetings.

Consistently cited as a great place to work, our company employs talented people who discover, develop, manufacture and market a wide range of vaccines and medicines to address unmet medical needs. Each of us is joined by an extraordinary sense of purpose — bringing our company's finest achievements to people worldwide. The South San Francisco campus is located within the heart of the industry in the Bay Area. This close proximity allows for close interactions with the quickly expanding high-resolution single-particle cryo-EM community as well as the structural biology field at large, giving easy access to the latest developments in the field.


[Post Date: April 6, 2020]


Senior Structural Biologist, Schrödinger

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Description:

Schrödinger’s mission is to revolutionize drug discovery through the use of breakthrough computational methods.  We are currently looking for outstanding individuals to join our drug discovery group and contribute to our rapidly expanding portfolio of drug discovery collaborations.

Our Drug Discovery Group of over 60 scientists includes designers, modelers, computational chemists, medicinal chemists, crystallographers, biochemists, and biologists with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers as well as a large scale compute infrastructure. Four of the programs we’ve worked on in the past 7 years have progressed into the clinic; two are still progressing through trials and two have been approved by the FDA. 

We are looking for a highly motivated structural biologist with demonstrated experience in the fields of X-ray crystallography and cryoEM. The ideal candidate will have a thorough understanding of both of these methodologies and broad experience using the computational tools required for structure determination.

Responsibilities:

  • Provide expertise in structure solution and refinement to the Drug Discovery Group
  • Participate as a member of multiple internal drug discovery teams
  • Contribute to the work of identifying new potential drug targets which are amenable to Schrödinger’s technology platform
  • Provide oversight of the work of structural biology CROs, including assessment and further refinement of the structures they provide from both X-ray crystallography and cryoEM
  • Participate in ongoing research and development of Schrödinger’s technology for solving and refining protein structures

Essential Qualifications, Skills and Experience:

  • Ph.D. in chemistry, computational biology, chemical physics, or related fields
  • Understanding of structural biology methods
  • Expertise with a broad range of software tools in protein crystallography and cryoEM
  • Peer-reviewed publications in structural biology or related fields
  • Excellent communication skills, both written and verbal
  • Five or more years of relevant industrial experience

Desirable Skills and Experience:

  • Knowledge of drug discovery processes and experience collaborating in a drug discovery environment
  • Knowledge of computational chemistry methods, especially molecular dynamics
  • Familiarity with protein modifications to improve their ability to crystallize
  • Experience building models where the resolution of experimental data is very limiting
  • Experience with methods used to model protein loops without direct experimental results
  • Knowledge of protein homology modeling and relationships between protein sequence and structure
  • Experience with Python

Pay and perks:

Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, stock options, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have catered meals in the office every day, a company culture that is relaxed but engaged, and over a month of paid vacation time.  Our Administrative and Human Resources departments also plan a myriad of fun company-wide events - last summer we went tubing down the Delaware River! New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been selected as one of Crain's New York Best Places to Work 2018.

Sound exciting? Apply today and join us!

As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company’s mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, national origin, citizenship status, marital status, union status, sexual orientation, or gender identity. To us, “diversity” isn’t just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. Greater diversity doesn’t just mean better headlines or public images—it means increased adaptability and profitability.


[Post Date: April 2, 2020]