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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Postdoc Positions in Protein Engineering at Rice University

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Description:

The Lab for Synthetic Macromolecular Assemblies (PI: George J. Lu) at Rice Bioengineering has multiple openings for postdoctoral fellows. The research focuses on the understanding and engineering of a class of gas-filled protein nanostructures named gas vesicles, and use them to develop novel imaging and cellular control technologies for basic research and cell therapies. Gas vesicles were recently shown to enable ultrasound- and MRI-based imaging of gene expressions in therapeutic microbes and mammalian cells (Nature Materials 2018; Nature Protocols 2017; Nature 2018; Science 2019), and have future applications in remote cellular control and biomaterials. The qualified postdoc researchers recruited here will lead projects in understanding the molecular mechanism of gas vesicles, engineering novel genetic variants, and developing imaging and cellular control platforms that incorporate these agents.

Dr. Lu was previously awarded the Young Investigator of the Year from the World Molecular Imaging Society for his work on the development of acoustically erasable MRI reporter genes. The independent lab was newly established in 2020 with the support of the NIH Pathway-to-independence (K99/R00) and the Cancer Prevention and Research Institute of Texas (CPRIT) Scholar awards.

The ideal candidate will have strong expertise in one or several of the following areas: protein structural biology, computational protein design, directed evolution and high-throughput screening, microbial engineering, mammalian synthetic biology, and ultrasound imaging. The candidate should have strong written and oral communication skills, and will also be expected to aid in the supervision of junior lab members and in the preparation of research proposals. The application for postdoctoral fellowships will be encouraged, including both external and internal ones such as Rice University Academy of Fellows. The pay scale for the position follows NIH guidelines.

Rice Bioengineering is one of the top biomedical engineering departments with its graduate program consistently ranked among the top 10 in the country. The candidate will have opportunities to lead cutting-edge research projects and interact with outstanding scientists as collaborators and trainees.

Rice University is an Equal Opportunity Employer with commitment to diversity at all levels, and considers for employment qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national or ethnic origin, genetic information, disability, or protected veteran status.

To apply, please visit https://jobs.rice.edu/postings/24661 or email a cover letter and a copy of CV/resume to george.lu@rice.edu.


[Post Date: October 15, 2020]


Senior Scientist Structural Biology

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Description:

For the expansion of our drug discovery team in Ghent (Belgium) we are currently looking for a Senior Scientist Structural Biology. Please send your CV and short motivation letter to veli-pekka.jaakola@confotherapeutics.com if you are interested.

Confo Therapeutics, a spin-off of VIB and VUB, is a drug discovery company built around a disruptive technology which enables it to address 'undruggable' -protein coupled receptors (GPCRs). The company is building a portfolio of transformative medicines in various disease areas. Confo has a unique technology which makes use of antibody fragments or "ConfoBodies(r)" to stabilize GPCRs in a particular conformation of interest as a superior starting point for protein structure determination. Recently, Confo secured an exclusive license to the Megabody(tm) technology. Megabodies enable to produce high resolution cryo-EM structures of membrane proteins, overcoming current protein size limitations and potential preferential orientation issues in the study of GPCRs via cryo-EM.

More information about Confo's technology and strategy can be found on www.confotherapeutics.com.

Your responsibilities:

Biophysical, X-ray and EM experiments to produce GPCR structural biology results: provide experimental structural input and support to drive NCE projects to achieve milestone goals Working closely with medicinal chemists and biologist to help advance the project and technology platforms Supervising and coaching one or more research associates Leading the integrated discovery activities of projects as a core member of project teams Coordination and management of drug discovery projects: in a project leader role, you will be expected to maintain focus and provide direction to the team members with clear project plans and defined timelines, maintain productive relationships with project team members and communicate progress against goals in a multidisciplinary setting: chemistry, biology, pharmacology, and modeling

Your profile:

PhD or equivalent experience in a related field, with at least 3 years of experience as post-doc or in a company Extensive technical skills in purification, sample preparation for and design and implementation of crystallization trials as well as demonstrated experience in crystal optimization techniques for membrane proteins Demonstrated experience in sample preparation and optimization for cryo-EM studies on membrane proteins Demonstrated expertise in data collection and interpretation of both X-ray crystallography and cryo-EM co-structure data to support NCE optimization Experience with protein biophysical characterization ((F-)SEC, spectroscopic methods in detergent/lipid environment) and screening (thermal shift, NMR, SPR, fragment-like molecule screening) is a plus Highly collaborative, self-motivated, team-oriented individual Ability to work in a fast-paced, highly integrated team environment where accuracy, accountability and timeliness are essential You are fluent in English and can communicate research results to the team and cross-functional stakeholders across the company

Our offer:

A competitive compensation package with extensive benefits An entrepreneurial and stimulating working environment in a growing and ambitious biotech company Excellent career development opportunity, with exposure to all aspects of R&D in the company, with external collaborators and partners


[Post Date: October 15, 2020]


Research Technician

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Description:

A Research Technician position is available in the High Throughput Crystallization Laboratory at EMBL Grenoble.

The HTX lab is one of the largest platforms for automated macromolecular crystallization screening in Europe and is offering services through Instruct and the EC-funded project iNEXT-Discovery. The Marquez Team has developed stream-lined pipelines for fragment screening by X-ray crystallography based on the CrystalDirect technology for automated crystal harvesting and the CRIMS software. These pipelines are applied to study targets of biotechnological and biomedical relevance. The successful candidate will contribute towards the operation of the HTX facility, the development of innovative methods in protein crystallography and will participate in research projects.

Applications should be submitted through the www.embl.de/jobs/ portal.

Deadline for applications is November 22nd.


[Post Date: October 15, 2020]


Senior Scientist Structural Biology

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Description:

Job Description:

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

Our presence in the UK goes back a long way. For over 80 years, we’ve been researching, developing and supplying new medicines and vaccines that prevent and treat diseases that occur at every stage of life. Today we're one of the top five biopharmaceutical companies in the UK and employ over 2,000 people across five sites in Hertfordshire, Northumberland, Buckinghamshire, Edinburgh and London. We are officially certified by the Top Employer Institute and been awarded the exclusive Top Employer United Kingdom Certification for the second year running.

Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. 

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

We have exciting plans to establish a new state-of the-art Research and Discovery Centre in London’s ‘Knowledge Quarter’ opposite King’s Cross Railway station. Our new site, expected to be completed within the next 5 years, will employ circa 800 people across our research and commercial divisions.

We are currently seeking a highly motivated and exceptional Structural Biologist (Senior Scientist) to join Our Company’s Drug Discovery team based at the Francis Crick Institute. 

Role overview:

At Our Company, you will participate in a vibrant culture, connecting with leading academic and biotech research centres as well interacting with structural biology centres such as the DIAMOND synchrotron and EM facility.  This position within the Discovery Chemistry organization at Our Company will support drug discovery using single particle cryoEM, x-ray crystallography, and biophysics to determine the structure and function of therapeutically important targets. 

Role responsibilities:

The successful candidate will join our growing Structural Biology team and will be responsible for all aspects of the structural biology process, from sample preparation and data collection through to data processing and structure determination and will work in collaboration with Medicinal and Computational Chemists. 

They will work closely with Molecular Biologists, Biochemists and Biophysicists for protein sample optimization as reagents and candidates for structural studies.  Productive and collaborative interactions with other members of the global, cross-functional department are required. 

The position requires active interaction with the external scientific community to continually improve scientific understanding, including presentations at national or international meetings. 

To accomplish the above, the successful candidate must have excellent interpersonal, cross functional collaboration and communication skills, in addition to rigorous scientific thinking.

Education Required: 

•    A PhD in the field of Structural Biology is required and 3+ years of experience in a pharmaceutical or biotech setting.

Experience required:   

•    Demonstrated experience in a broad range of activities for x-ray crystallography and/or atomic resolution single particle cryo-EM, including sample preparation, data collection, image processing & structure determination.
•    Excellent communication skills (written, presentation, and oral) that enhance team-based progress is required.  Application of those skills to ensure clear understanding of program status for therapeutic area project teams and management is required.
•    Demonstrated potential to develop project management skills and identify/develop new areas of scientific expertise in structural biology.
•    Ability to work effectively and flexibly within timelines.
•    Ability to prepare peer-reviewed publications.

Skills/Competencies:

•    Experience with structure determination of small molecule protein complexes.
•    Experience with the application of hybrid structural techniques to answer biological questions.
•    Ability to manage multiple projects and independently prioritize work to align with evolving program needs.
•    Experience with protein expression and purification.
•    Experience with developing biochemical and biophysical assays.
•    Experience with biophysical and functional characterization methods (e.g.  SPR, NMR, thermal shift and calorimetric assays) to guide construct design and optimization of solution conditions for successful structural outcomes.
•    Experience with collaboratively engaging internal and external research groups to execute on scientific projects.
•    Experience using computational tools for protein engineering and design.

Your role at our company is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At our company, we’re inventing for life. 

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively for the common good. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace. 

The deadline for applications Friday 6th of November.


[Post Date: October 13, 2020]


Postdoc in Fluctuation X-ray Scattering

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Description:

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 46.000 students, 7.300 employees and a turnover of SEK 7.3 billion.

This position is located at the Department of Cell and Molecular Biology starting as soon as possible. The Cell and Molecular Biology department at Uppsala University has a strong and international research and teaching environment and is organized in six major research programs; Computational Biology and Bioinformatics, Microbiology, Molecular Biophysics, Molecular Evolution, Molecular Systems Biology, Structure and Molecular Biology. In total the department has over 200 scientists, including 60 PhD students.

The current position is located within the research group of Filipe Maia within the Molecular Biophysics. More information can be found at https://biox.io/ and https://lmb.icm.uu.se.

Project description: Detecting the atomic structure of biomolecules is the basis for understanding biological function at the molecular level. This knowledge has led to enormous scientific advances, important drugs, and disruptive technologies. Structural methods exist, but many biomolecules have escaped structure determination; structural changes due to interactions cannot be easily characterized, and enzymatic mechanisms are hard to detect due to an insufficient time-resolution.

The project will develop fluctuation correlation X-ray scattering (FXS) with powerful X-ray free-electron lasers (XFEL), capable of producing extremely intense and ultra-short X-ray pulses radiation, which promises to determine the structure of biomolecules in biologically native conditions with light-triggered pump/probe experiments. The method is a natural extension of traditional small-angle X-ray scattering (SAXS). It has been demonstrated in 1977 by Kam for macroscopic objects based on scattering by visible light. Recent reports indicate that it is in principle possible to determine the structure of proteins in solution with FXS. If successful, this project will establish FXS as a new method for structure determination of biomolecules in native, ‘biological‘, conditions.

Duties: The applicant is expected to drive multiple ambitious projects within the area. The position involves carrying out FXS experiments on biological samples at leading XFELs along with all the associated preparation and analysis of the resulting data. The project aims to build up a new experimental setup, the position therefore also involves work on designing and developing this new setup. Oral presentation and writing/editing of scientific papers and grant applications are part of the position.

Requirements: To qualify for an employment as a postdoctor you must have a PhD degree or a foreign degree equivalent to a PhD degree in physics, biophysics or in a area similar to these. The PhD degree must have been obtained no more than three years prior to the application deadline. (The three year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc.)

We are looking for highly-motivated candidate who is able to work independently and has a strong interest in coherent X-ray imaging and method development. You are expected to take your own initiatives as well as being able to collaborate with other colleagues both within and outside the research group. The position is in an international context so good oral and written communication skills in English are essential. Finally, significant weight will be given to personal suitability such as; analytical and organizational skills, personal maturity, ability to work with others, take initiatives, and to show good judgement.

Additional qualifications:

- Documented experience with fluctuation X-ray scattering (FXS) is an advantage.
- Documented experience with gas dynamic virtual nozzles (GDVNs) is an advantage.
- Documented experience with X-ray experiments, specially at XFELs, is an advantage.


[Post Date: October 13, 2020]


Postdoc University of Texas Health Science Center at San Antonio

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Description:

A postdoctoral position is immediately available for a highly motivated individual interested in understanding the structural mechanisms of ubiquitin signaling. Research is focused on understanding basic molecular mechanisms of the enzymatic machinery responsible for protein ubiquitination, structural characterization of PROTAC complexes with potential therapeutic value, and structure determination of large protein complexes regulated by ubiquitin signaling, particularly those involved in DNA repair. These issues will be addressed using a multidisciplinary approach that includes X-ray crystallography and cryoEM complemented with biochemical/biophysical techniques and cell based assays.

Candidates should hold a recently obtained PhD in biochemistry, chemistry, or related subject, with demonstrated expertise in X-ray crystallography, cryoEM, and/or the biochemical analysis of protein ubiquitination. Experience with protein expression in insect and mammalian cells is a plus.

Interested candidates should e-mail a cover letter, CV, and the names of three references to: olsens@uthscsa.edu.


[Post Date: October 12, 2020]


Senior Crystallography Scientist

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Description:

Evotec is a global, publicly listed biotechnology company with more than 3,000 employees at 13 sites, our headquarters are located in Hamburg. We do research on innovative approaches to drug discovery and development for and with leading pharmaceutical and biotechnology companies and academic institutions. By assembling top-class scientists, state-of-the-art technologies as well as substantial experience and expertise in key therapeutic areas including neuroscience, diabetes and complications of diabetes, pain and inflammation, oncology and infectious diseases, Evotec has established a unique leading position.

Required knowledge, skills and abilities:

  • Extensive knowledge in protein biochemistry and macromolecular crystallography
  • Experience with protein purification
  • Protein engineering, bioinformatics and molecular biology (Construct design and cloning strategy)
  • Familiar with Biophysic techniques (DSF, ITC…)
  • A working knowledge and practical experience with either E. coli, insect or mammalian expression systems
  • The successful candidate will have experience working in multi-disciplinary teams
  • Experience collaborating with scientists in external organisations

Responsibilities includes:

  • Reading scientific literature relevant to the project
  • Supporting a project team by designing and ordering constructs to initiate the project
  • Adapting scientific knowledge to resolve problems encountered in achieving defined goals with assistance from line manager or other team members to meet internal and project deadlines
  • Preparing reports, presenting data, and collaborating with other scientists at Evotec
  • Presenting own work at project technical meetings, and department technical meetings when required
  • Demonstrating full command of all techniques and tools required for assigned responsibilities within the given project
  • Ensuring safe working practices of themselves and any direct reports
  • Complying fully with the company safety policy (including COPs and SOPs) when performing experiments
  • Adhering to Lab Notebook guidelines regarding accurate documentation of lab experiments

Desirable Knowledge, Skills and Abilities:

  • Experience in Cryo-EM
  • Self-motivated, enthusiastic, cooperative and reliable
  • Knowledge of basic laboratory techniques, and understanding of the science underlying the techniques and experiments
  • Experience of working in a lab environment
  • The ability to adapt to changing demands whilst operating under pressure to deadlines
  • The ability to work accurately and with attention to detail
  • Good interpersonal skills and the ability to work well with other scientific staff
  • The ability to work well independently, and as part of a team
  • Good organisational and time management skills
  • Good verbal communication skills
  • Ability to maintain excellent laboratory records
  • Computer proficiency

Education & Experience:

PhD degree in Structural Biology, Biochemistry or related area


[Post Date: October 12, 2020]


Scientist X-ray Crystallography at ZoBio in Leiden (NL)

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Description:

Scientist X-ray Crystallography at ZoBio in Leiden (NL)

ZoBio (www.zobio.com) was founded in 2004 and is located in Leiden, Netherlands. We offer innovative research services in the field of small-molecule drug discovery to the pharmaceutical and biotech industries. Our international team of 27 people covers four fields of expertise: Protein Engineering and Production, Assay Development and Screening, Structural Biology and Medicinal Chemistry.

We are currently looking to strengthen our team with an X-ray crystallographer with a track record in protein crystallography and a strong background in the X-ray crystallographic data analysis. In particular, experience in building and refinement of protein – small-molecule complexes would be extremely helpful.

The successful applicant will support our clients’ drug discovery programs by solving ligand-protein structures. You will work with minimal supervision but in a highly collaborative environment within the Structural Biology team and will effectively cooperate on a per-project basis with other research groups at ZoBio. This role requires working on multiple projects simultaneously and in a rapidly evolving environment. Team spirit and excellent organization and communication skills are essential.

RESPONSIBILITIES

High-throughput crystallographic screening utilizing automation and robotics.

High-throughput and -quality structure elucidation and interpretation of biological macromolecules in complexes with small molecules of interest.

Utilization of X-ray crystallography pipelines with the aid of computational structural biology tools to aid the efficient structure elucidation of protein-ligand complexes.

Report results to the Head of Crystallography and prepare presentations on the structural data for the project teams and clients.

Maintain up-to-date understanding of the state-of-the-field in X-ray crystallography in relation to modern drug discovery challenges.

REQUIREMENTS

  • PhD in relevant field with experience in an industrial or collaborative setting.
  • Hands-on experience with ligand modelling into electron density maps and macromolecular model building and refinement in the context of Structure-Based Drug Discovery campaigns.
  • Hands-on experience in solving challenging X-ray crystallography cases (e.g. ab initio structure solution).
  • Experience with computational structural biology tools like ligand docking, virtual screening, molecular dynamics simulation would be considered as an advantage. 
  • Experience in scripting and programming would be considered as an advantage.
  • Able to work in a team in a result-driven, goal-oriented environment.

It is fully expected that you will become a permanent and integral member of the ZoBio team, after an initial period of 12 months. Applicants at either the Senior Scientist or Scientist level will be considered. 

A tailored remuneration package will be proposed in line with individual qualifications and experience. The position is immediately available; the evaluation and assessment of candidates will run until the position is filled but not later than November 1st 2020. 

Please send your CV, motivation letter and names of potential referees at info@zobio.com with the subject: “Scientist position in X-ray Crystallography”.


[Post Date: October 12, 2020]


Tenure Track Faculty Position in Biochemistry, Samford University

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The Chemistry and Biochemistry Department at Samford University (Birmingham, AL) is seeking an Assistant Professor on a 9 month tenure track appointment to teach courses that include and lead an undergraduate research program in biochemistry.

Details of the position and the materials required in the application package can be found at: https://www.samford.edu/employee/faculty-employment-opportunities/Assistant-Professor-Department-of-Chemistry-and-Biochemistry-9-Mo-TT-Appointment.pdf

Review of applications has begun and will continue until October 30. Please direct all inquiries to Dr. Chris Pursell, chair of the search committee and the department, at chris.pursell@samford.edu.


[Post Date: October 8, 2020]


Postdoc Structural Biology Crystallography and Protein Engineering Unit at the Spanish National Cancer Research Centre (CNIO)

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Description:

We are looking for a highly motivated structural biologist to join the Crystallography and Protein Engineering Unit at the Spanish National Cancer Research Centre (CNIO), as a postdoctoral fellow, with a 2 years’ contract BBVA-funded project.

The work will be focused on developing a therapeutic antibody against SARS-CoV-2. The successful applicant will use interdisciplinary approaches including structural biology techniques (X-ray crystallography and cryoEM), molecular biology and biochemistry. Also, the candidate must have experience in both insect and mammalian cells protein production.

Feel free to contact me for informal inquiries before 30 October. Inés G. Muñoz, Head of Crystallography & Protein Engineering Unit, Structural Biology Programme imunoz@cnio.es

https://www.cnio.es/en/research-innovation/scientific-programmes/structural-biology-programme/crystallography-and-protein-engineering-unit/


[Post Date: October 8, 2020]


Tenure-track Faculty Position

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Description

The University of Missouri (MU) invites applications for a tenure-track faculty position in the School of Medicine (SOM) and Department of Biochemistry, which is jointly affiliated with the College of Agriculture, Food and Natural Resources (CAFNR) and SOM. Responsibilities will include contributions to medical, graduate and undergraduate education. This is one in a series of recruitments. We seek applications in areas of including gene/genome regulation, gene delivery and transgenic technology, synthetic biology, medicinal biochemistry, structural biology and imaging, including development of new molecular markers and reporters. Of particular interest are areas of fundamental science that might relate to emerging strengths in biomedical translation, precision health and/or electron microscopy (see below).

Responsibilities: We seek dynamic individuals who will lead federally-funded research programs, contribute to medical, graduate and/or undergraduate education programs through instruction and research mentorship, and contribute to academic service on the campus and/or professionally.

Required Qualifications: An earned doctorate.

Preferred Qualifications: A record of research in an area of biomedically-relevant biochemistry that complements departmental strengths.  Applications for this position at the Assistant Professor level are encouraged, but candidates at a higher level will be considered if there is evidence of continuous extramural research funding, high impact publications and excellence in teaching and service expected of tenured faculty at a research-intensive university. A record of successful post-doctoral research; ability to communicate effectively in a research and educational setting; and evidence of past research collaborations or a willingness to work in related research areas.

About MU and Biochemistry: MU is the flagship campus of the University of Missouri System. The University is located midway between St. Louis and Kansas City in Columbia, a vibrant community consistently ranked among the top small cities to live in the nation. MU Biochemistry has a reputation for excellence in interdisciplinary research and effective instruction. Current strengths include medical biochemistry, plant biochemistry and biophysical, structural and mechanistic biochemistry. The department forms a bridge between fundamental molecular science and translation into biomedical and agricultural applications. Biomedical advances will be anchored by the $225M NextGen Precision Health Institute, opening Fall 2021, that will house an Electron Microscopy center with multiple state-of-art instruments. For additional information, visit biochem.missouri.edu.

Application: Apply online using Job ID 34530 and submit: (1) a cover letter; (2) a curriculum vitae; (3) a one-page summary of research accomplishments with two pages of future plans; (4) a narrative of teaching philosophy and diversity inclusion; and (5) names and contact information of four references. Review of applications will begin on November 16, 2020 and will continue until the position is filled. For information, contact Dr. Jack Tanner, Chair of the Search Committee (tannerjj@missouri.edu).

Benefit Eligibility: This position is eligible for a comprehensive University benefits package, including medical, dental and vision plans, retirement, and educational fee discounts. (umsystem.edu/totalrewards/benefits)

The University of Missouri is an Equal Access, Equal Opportunity, and Affirmative Action Employer. We are fully committed to achieving the goal of a diverse and inclusive academic community of faculty, staff and students. We seek individuals who are committed to this goal and our core campus values of respect, responsibility, discovery and excellence.


[Post Date: October 8, 2020]


Senior Investigator/Principal Investigator, Biochemistry

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Description:

Company

Silicon Therapeutics (“SITX”) is a privately-held, physics-driven integrated drug discovery company in the preclinical IND stage targeting innate immunity to start, but with the capability to move into many other franchise opportunities. The Company’s initial pipeline is focused on modulation of the innate immune system to “light the spark” within immunologically cold tumors by using its physics-enabled drug discovery engine for the design of small molecule therapeutics and the lead program is in late stage preclinical studies. SITX’s discovery efforts as well as physics-based platform are all completely in-house, with a full wet lab as well as a team of over 25 experienced R&D professionals spanning biology, biochemistry, chemistry, biophysics (NMR + X-ray) & preclinical sciences. SITX’s engine leverages quantum mechanics and molecular dynamics, which are deployed on its own internal super computer composed of over 400 GPU’s and FPGA’s and allows SITX to accurately simulate the physical motion and properties of biological targets at an atomistic level resolution. The platform is completely proprietary to SITX and was built from the ground up with the purpose of addressing difficult targets and using simulations to break through bottlenecks that has plagued traditional drug discovery approaches on such targets. It is currently the ONLY company which owns the entire spectrum of physics-driven drug discovery from chip-to-clinic with a team of over 60  individuals in Boston.

The Company’s initial focus in on innate immunity and its pipeline is currently composed of one project entering into IND-enabling studies, another one entering hit-to-lead and two more ramping up. It’s unique advantage in designing small molecules using all atom simulations has allowed it to advance a systemically available small molecule STING agonist into a preclinical development. The program is ramping up for IND enabling studies entry to the clinic in 2020. This differentiated product can be administered systemically via an IV dose and has single agent effects in early mouse efficacy studies using PD1 resistant tumor models and is a “rule-of-5” compliant small molecule. Beyond this one program, the Company is also advancing an ADAR inhibitor which can be considered an innate immune check-point as well as a multitude of targets that explore Innate Immunity’s role in cancer biology

Job Summary

Silicon Therapeutics is seeking experienced, lab-savvy research professional with deep expertise in enzymology, biochemistry, assay development and compound screening.  Core responsibilities include biochemical assay development, small molecule hit-ID screening and routine testing of compounds in a variety of assays. This is an exciting role for a scientist who is looking to contribute to the discovery and development of cancer therapies. The successful candidate will work as part of a collaborative team of scientists with expertise in protein production and biophysics supporting hit-ID, hit-to-lead, and lead-ID phases of our innate immuno-oncology drug discovery programs and will have the opportunity to mentor and lead junior colleagues.

Job Responsibilities

  • Design, implement, and troubleshoot in vitro biochemical assays for compound library screening and routine small molecule testing.
  • Together with senior colleagues propose and implement enhancements to the biochemical screening pipeline.
  • In collaboration with group members, design protein constructs for use in biochemical assays.
  • Work as part of a cross-functional project team(s) to provide timely, robust, high-impact results.
  • Carefully document research workflows, data and protocols using an electronic laboratory notebook.
  • Capture experimental results in database.
  • Organize and present data to group members and project team members.
  • Mentor and lead junior colleagues.
  • Other duties as assigned


[Post Date: October 7, 2020]


Investigator/Senior Investigator/Principal Investigator, Biophysics/Structural Biology

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Description:

Company

Silicon Therapeutics (“SITX”) is a privately-held, physics-driven integrated drug discovery company in the preclinical IND stage targeting innate immunity to start, but with the capability to move into many other franchise opportunities. The Company’s initial pipeline is focused on modulation of the innate immune system to “light the spark” within immunologically cold tumors by using its physics-enabled drug discovery engine for the design of small molecule therapeutics and the lead program is in late stage preclinical studies. SITX’s discovery efforts as well as physics-based platform are all completely in-house, with a full wet lab as well as a team of over 25 experienced R&D professionals spanning biology, biochemistry, chemistry, biophysics (NMR + X-ray) & preclinical sciences. SITX’s engine leverages quantum mechanics and molecular dynamics, which are deployed on its own internal super computer composed of over 400 GPU’s and FPGA’s and allows SITX to accurately simulate the physical motion and properties of biological targets at an atomistic level resolution. The platform is completely proprietary to SITX and was built from the ground up with the purpose of addressing difficult targets and using simulations to break through bottlenecks that has plagued traditional drug discovery approaches on such targets. It is currently the ONLY company which owns the entire spectrum of physics-driven drug discovery from chip-to-clinic with a team of over 60  individuals in Boston.

The Company’s initial focus in on innate immunity and its pipeline is currently composed of one project entering into IND-enabling studies, another one entering hit-to-lead and two more ramping up. It’s unique advantage in designing small molecules using all atom simulations has allowed it to advance a systemically available small molecule STING agonist into a preclinical development. The program is ramping up for IND enabling studies entry to the clinic in 2020. This differentiated product can be administered systemically via an IV dose and has single agent effects in early mouse efficacy studies using PD1 resistant tumor models and is a “rule-of-5” compliant small molecule. Beyond this one program, the Company is also advancing an ADAR inhibitor which can be considered an innate immune check-point as well as a multitude of targets that explore Innate Immunity’s role in cancer biology.

Job Summary

Silicon Therapeutics is seeking a highly motivated and thoroughly experienced scientist with expertise that bridges biophysics and structural biology.  Core responsibilities include design and execution of complex experiments bridging and blending multiple disciplines (biochemistry, biophysics, structure) with the goal of developing deep practical understanding of biological processes and applying the learnings to protein-ligand interaction studies in pharmaceutical Discovery context. This is a challenging and exciting position for someone who is passionate to make a difference in patients’ lives through the discovery and development of innovative cancer therapies. The successful candidate will work as part of a collaborative team of scientists with expertise in protein production and biophysics supporting hit-ID, hit-to-lead, and lead-ID phases of our innate immuno-oncology drug discovery programs and will have the opportunity to mentor and lead junior colleagues.

Job Responsibilities

  • Adapt the latest biophysics and structural biology techniques to the study of protein-ligand interaction.
  • Lead from the bench by filling gaps in understanding of fundamental processes from biophysical and structural perspective; then applying the learnings towards rapid discovery and evaluation of new chemical matter.
  • In collaboration with group members, design protein constructs and help purifying and analyzing them.
  • Work as part of a cross-functional project team(s) to provide timely, robust, high-impact results.
  • Carefully document research workflows, data and protocols using an electronic laboratory notebook.
  • Capture experimental results in database.
  • Organize and present data to group members and project team members.
  • Mentor and lead junior colleagues.
  • Other duties as assigned


[Post Date: October 7, 2020]


Research Associate, Biochemistry/Biophysics/Structural Biology

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Description:

Company

Silicon Therapeutics (“SITX”) is a privately-held, physics-driven integrated drug discovery company in the preclinical IND stage targeting innate immunity to start, but with the capability to move into many other franchise opportunities. The Company’s initial pipeline is focused on modulation of the innate immune system to “light the spark” within immunologically cold tumors by using its physics-enabled drug discovery engine for the design of small molecule therapeutics and the lead program is in late stage preclinical studies. SITX’s discovery efforts as well as physics-based platform are all completely in-house, with a full wet lab as well as a team of over 25 experienced R&D professionals spanning biology, biochemistry, chemistry, biophysics (NMR + X-ray) & preclinical sciences. SITX’s engine leverages quantum mechanics and molecular dynamics, which are deployed on its own internal super computer composed of over 400 GPU’s and FPGA’s and allows SITX to accurately simulate the physical motion and properties of biological targets at an atomistic level resolution. The platform is completely proprietary to SITX and was built from the ground up with the purpose of addressing difficult targets and using simulations to break through bottlenecks that has plagued traditional drug discovery approaches on such targets. It is currently the ONLY company which owns the entire spectrum of physics-driven drug discovery from chip-to-clinic with a team of over 60  individuals in Boston.

The Company’s initial focus in on innate immunity and its pipeline is currently composed of one project entering into IND-enabling studies, another one entering hit-to-lead and two more ramping up. It’s unique advantage in designing small molecules using all atom simulations has allowed it to advance a systemically available small molecule STING agonist into a preclinical development. The program is ramping up for IND enabling studies entry to the clinic in 2020. This differentiated product can be administered systemically via an IV dose and has single agent effects in early mouse efficacy studies using PD1 resistant tumor models and is a “rule-of-5” compliant small molecule. Beyond this one program, the Company is also advancing an ADAR inhibitor which can be considered an innate immune check-point as well as a multitude of targets that explore Innate Immunity’s role in cancer biology

Job Summary

Silicon Therapeutics is seeking an energetic, passionate practitioner of the laboratory arts to join the Biochemistry/Biophysics/Structural Biology platform as a Research Associate . This is a foundational support role for someone who enjoys technical challenges and is not afraid to get their hands dirty by helping with core lab functions from cell culture, protein purification, or biochemical experiments all the way to laboratory automation, instrument maintenance, etc. The qualified candidate will have basic laboratory practices under their belt and would be passionate to learn additional techniques while supporting a  growing group dedicated to Discovery research. The successful candidate will work as part of a collaborative team of scientists with expertise in protein production, biochemistry, structure, and biophysics supporting hit-ID, hit-to-lead, and lead-ID phases of our innate immuno-oncology drug discovery programs and will have opportunities to learn cutting edge techniques.

Job Responsibilities

  • Responsible for bacterial and eukaryotic cell culture for the purpose of recombinant protein expression.
  • Basic protein purification under supervision of expert practitioners.
  • Preparation of common biochemical reagents, maintenance of lab readiness.
  • Biochemical/biophysical characterization of recombinant proteins
  • Work as part of a cross-functional project team(s) to provide timely, robust, high-impact results.
  • Carefully document research workflows, data and protocols using an electronic laboratory notebook.
  • Capture experimental results in database.
  • Organize and present data as needed
  • Other duties as assigned


[Post Date: October 7, 2020]


Postdoctoral Fellow position at Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA

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Description:

A postdoctoral fellow position is currently available at Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA

The collaborative Prof. Jia-huai Wang and Prof. Ellis Reinherz labs at Dana-Farber Cancer Institute and Harvard Medical School are recruiting a postdoctoral fellow to study structural immunology. We use interdisciplinary approaches at the interface of structural, molecular mechanism of cellular immunity with the aim of translating these insights into immunotherapy. Specific research directions include structural and molecular studies of T cell development. The laboratory provides a full access to cutting-edge techniques in molecular biology, protein chemistry, NMR and protein crystallography.

Highly-motivated candidates with a recent PhD or MD/PhD in structural biology and significant experience in molecular biology, biochemistry and immunology are encouraged to apply. Skills in molecular cloning, protein chemistry and crystallography are essential. Candidates should have a publication record in peer-reviewed journals. We are seeking a candidate with excellent writing and communication skills, able to work independently but also effectively with other lab members. Applicants should include a short statement of research goals, CV and three references with their application.

Please contact Prof. Jia-huai Wang at jwang@crystal.harvard.edu.


[Post Date: October 5, 2020]


Assistant or Associate Professor

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Description:

Case Western Reserve University, Department of Biochemistry invites applications for tenure-track faculty or tenured faculty positions. While applications from individuals with interests in any area of biochemistry are requested, areas of specific interest include metabolism/metabolomics, RNA biology, stress response signaling, and chromatin biology as they pertain to fundamental aspects of human diseases such as cancer biology.

More details are here in the ad posted on the ASBMB website:

https://careers.asbmb.org/job/assistant-or-associate-professor/54848389/ 


[Post Date: October 5, 2020]


Professor/Reader/Senior Lecturer of Structural Biology

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Description:

Newcastle University is delighted to be recruiting for a Professor / Reader / Senior Lecturer of Structural Biology to work within the Biosciences Institute in the Faculty of Medical Sciences.

https://jobs.ncl.ac.uk/job/Newcastle-ProfessorReaderSenior-Lecturer-of-Structural-Biology/623899301/


[Post Date: October 5, 2020]


Postdoctoral position in the Houry lab at the University of Toronto

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Description:

A postdoctoral position is available immediately in the Dr. Walid A. Houry’s group for an excellent trainee to study the structure and function of molecular chaperones and ATP-dependent proteases. The successful candidate will have a PhD in Chemistry, Biochemistry, Molecular Biology or a related field. Strong knowledge of X-ray crystallography and cryoEM is required for this position. For more information about the projects, refer to the lab website: http://lab.walidhoury.com/

Please forward a cover letter and CV to walid.houry@utoronto.ca

 


[Post Date: October 5, 2020]


Scientist-I (Structural Biology) position at Frederick National Laboratory for Cancer Research

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Description:

The Frederick National Laboratory for Cancer Research is looking for a Scientist-I with experience in protein chemistry and structural biology. The candidate will join the structural biology group within the NCI RAS Initiative program and work on the protein-small molecule complexes.

For detailed information and to apply for this position, please use this link:
https://leidosbiomed.csod.com/ats/careersite/jobdetails.aspx?site=4&c=leidosbiomed&id=1404

 


[Post Date: October 5, 2020]


Post-Doctoral Position in Biochemistry and Structural Biology

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Description:

The Neutron Scattering Division invites applications for a post-doctoral biochemist or structural biologist to join its Large Scale Structures (LSS) group. Within the LSS group, the Biology Laboratory team focuses on capability development for neutron scattering studies of biological systems across the suite of instruments at the Spallation Neutron Source and High Flux Isotope Reactor. In this position, you will develop bio-deuteration and protein expression approaches, with a particular focus on dynamic protein assemblies, including intrinsically disordered proteins and membrane associated proteins. Areas of emphasis will be investigating low complexity protein domains relevant to Chlamydomonas metabolic pathways as well as the multi-domain proteins involved in plant cell wall synthesis. As an ORNL postdoctoral fellow, you will work with an interdisciplinary team and have access to a tool suite that includes leading small angle scattering and neutron diffraction facilities, bio-fermentation laboratories, and biophysical characterization laboratories, in addition to in-house small angle X-ray scattering and X-ray diffraction instrumentation. The position represents an excellent opportunity for you to develop your career and interact with leading scientists from around the world. You can find additional details about how to apply to the position here: https://career4.successfactors.com/sfcareer/jobreqcareer?jobId=4087&company=utbattelleP


[Post Date: October 5, 2020]


Postdoc Shifman Lab Hebrew University of Jerusalem

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Description:

Shifman lab in the Hebrew University of Jerusalem is looking for a postdoctoral scholar to study evolution of protein-protein interactions. Our lab has pioneered computational and experimental methodology for mapping changes in binding affinity due to thousands of mutations in protein complexes. The goal of the project is to apply the new methodology to various protein-protein interactions. We are looking for a highly motivated person with a background in Biophysics/Biochemistry/Structural Biology to take over this exciting project. The candidate should have experience with molecular biology and protein expression/purification. Experience in yeast surface display is a plus.  Contact Julia Shifman: jshifman@mail.huji.ac.il  https://openscholar.huji.ac.il/shifmanlab/about


[Post Date: September 30, 2020]


Two Postdoctoral/Research Associate positions in the Chazin laboratory at Vanderbilt University

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Description:

Two Postdoctoral/Research Associate positions in the Chazin laboratory at Vanderbilt University are available for highly motivated biologists, biochemists, or structural biologists.  These positions involve state of the art integrative structural biology (NMR, crystallography, SAXS, cryo EM, and modeling) in two key areas of biomedical research.  Opportunities are also available to pursue fragment-based discovery of small molecule inhibitors of critical protein-protein interactions.

One program focuses on multi-domain proteins and multi-protein complexes involved in DNA replication, damage response, and repair.  Projects include discerning the structural mechanisms of multi-protein machinery, the mechanistic basis for DNA priming, and the role of 4Fe-4S clusters and DNA charge transport in priming [e.g. O’Brien et al., Science 355, 813 & eaag1789, 2017].  The second Program is directed to infectious disease and the innate response.  These studies focus on the roles of calprotectin (CP) in nutritional immunity and in inflammation signaling via the receptor for advanced glycation end products (RAGE).  The candidate will join a team carrying out highly inter-disciplinary research in collaboration with microbiologist Eric P. Skaar and many other laboratories at Vanderbilt and around the world.  Studies include engineering the metal binding properties of CP, determining the structural mechanisms of CP activation of RAGE, and fragment-based discovery of small molecule inhibitors CP-RAGE interactions.

These positions provide an excellent opportunity to become experienced in the integrated applications of advanced structural/dynamics and chemical biology methods at the cutting edge of genome maintenance or infectious disease medicine and biology.  Applicants will work in multi-disciplinary teams with an extensive network of collaborators focused on fundamental biology and clinical applications, and will be encouraged to develop their leadership potential.  The Chazin laboratory is diverse and inclusive, and excels at fostering the achievement of the full potential of each group member and attaining career objectives.  To apply, send a CV and the names of at least two references to walter.chazin@vanderbilt.edu.


[Post Date: September 28, 2020]


Postdoctoral Fellow Position at Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA

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Description:

A postdoctoral fellow position is currently available at Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA

The collaborative Jia-huai Wang and Ellis Reinherz labs at Dana-Farber Cancer Institute and Harvard Medical School are recruiting a postdoctoral fellow to study structural immunology. We use interdisciplinary approaches at the interface of structural, molecular mechanism of cellular immunity with the aim of translating these insights into immunotherapy. Specific research directions include structural and molecular studies of T cell development. The laboratory provides a full access to cutting-edge techniques in molecular biology, protein chemistry, NMR and protein crystallography.

Highly-motivated candidates with a recent PhD or MD/PhD in structural biology and significant experience in molecular biology, biochemistry and immunology are encouraged to apply. Skills in molecular cloning, protein chemistry and crystallography are essential. Candidates should have a publication record in peer-reviewed journals. We are seeking a candidate with excellent writing and communication skills, able to work independently but also effectively with other lab members. Applicants should include a short statement of research goals, CV and three references with their application.

Please contact Dr. Jia-huai Wang at jwang@crystal.harvard.edu.


[Post Date: September 23, 2020]


Scientist - Further Understanding of Structure and Dynamics of SARS-CoV-2 proteins

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Description:

DESY

DESY, with its 2700 employees at its two locations in Hamburg and Zeuthen, is one of the world's leading research centres. Its research focuses on decoding the structure and function of matter, from the smallest particles of the universe to the building blocks of life. In this way, DESY contributes to solving the major questions and urgent challenges facing science, society and industry. With its ultramodern research infrastructure, its interdisciplinary research platforms and its international networks, DESY offers a highly attractive working environment in the fields of science, technology and administration as well as for the education of highly qualified young scientists.

The Center for Free-Electron Laser Science (CFEL) is designed to significantly advance science with next generation light sources and to join forces to explore structural changes of atoms, molecules, condensed, biological, or warm dense matter on femtosecond scales.

Within the project "Multidimensional serial crystallography of SARS-CoV-2 proteins to unravel structure and dynamics of function and inhibition" (MUXCOSDYN) the CFEL Coherent lmaging Division is seeking expertise in developing methods in serial crystallography and structure determination to explore and understand structure and dynamics of SARS-CoV-2 proteins.

The position

  • Developing, adapting and validating a set-up for for temperature- and pH-controlled automated high-throughput serial crystallography within the project "Multidimensional serial crystallography of SARS-CoV-2 proteins to unravel structure and dynamics of function and inhibition (MUXCOSDYN)"
  • Production, purification and crystallization of proteins from SARS-CoV-2
  • Supporting related experiments at both PETRAIII and the European XFEL
  • Using serial crystallography and complementary methods (e.g. spectroscopy, LC-MS, SAXS, binding studies) to determine structure and dynamics of proteins from SARS-CoV-2

Requirements

  • PhD in Biology, Chemistry or related sciences
  • Good knowledge in X-Ray Crystallography experiments, ideally experience with Serial Crystallography
  • Good knowledge and work experience regarding structure determination of biological macromolecules
  • Strong experience in Molecular Biology techniques and Protein Biochemistry
  • Good team player and very good English language skills

For further information please contact Dominik Oberthür +49-40-8998-6394 (dominik.oberthuer@desy.de).

The position is limited to 2 years.

Salary and benefits are commensurate with those of public service organisations in Germany. Classification is based upon qualifications and assigned duties. Handicapped persons will be given preference to other equally qualified applicants. DESY operates flexible work schemes. DESY is an equal opportunity, affirmative action employer and encourages applications from women. Vacant positions at DESY are in general open to part-time work. During each application procedure DESY will assess whether the post can be filled with part-time employees.


[Post Date: September 23, 2020]


Lab Product Manager (Protein Crystallization)

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Description:

Formulatrix, Inc. is looking to fill the role  of product manager for protein crystallization. You will be responsible for shaping the future of the protein crystallization business unit within Formulatrix, as well as aligning current and future technologies and software to the needs of our customers.

Product management requires a customer focused, hands-on, organized, and detail-oriented person able to work in a fast-paced environment. The ideal candidate will have a strong user-centered software design philosophy, excellent communication, cross-group collaboration and planning skills. Candidates must work well independently, with a global team and with customers.

Formulatrix requires hard work and dedication from its employees, and is committed to hiring only the best of the best. All support and management employees work 45 hour work weeks.

In return, Formulatrix offers a rewarding compensation package including base salary, bonuses, profit sharing, health and dental benefits, AFLAC supplemental insurance, a 401K retirement plan, a business casual work environment including Friday cookouts in the summer, and excellent growth opportunities.

Key Responsibilities

  • Take a leadership role in shaping the functionality and user experience of our protein crystallization software applications.
  • Prioritize and define features by working with customers, support and sales team.
  • Provide a vision for user experience and work with UX designers to detail the new features.
  • Oversee and support our development team in the implementation of new functionalities.
  • Support customers with protein crystallization product questions and requests.
  • Some domestic and international travel may be required.

Required Qualifications

  • Passion for customer satisfaction and great, high quality products.
  • BS + 5 years experience or MS + 3 years experience or PhD in a scientific field.
  • At least 3 years of experience in a laboratory setting (a graduate experience will be considered)
  • Strong leadership and verbal/written communication skills.
  • Excellent prioritization, organizational and planning skills.
  • Ability to learn and quickly adapt to a constantly changing environment.
  • Ability to work with an offshore team.

Preferred Qualifications

  • Experience with protein crystallography.
  • Experience with mammalian cell cultures.
  • Experience with commercially available laboratory automation.
  • Experience with graphical user interface design.
  • Experience with the entire software development lifecycle.

How to Apply

** RESUMES SUBMITTED WITHOUT THE INFORMATION REQUESTED BELOW WILL NOT BE CONSIDERED **

To be considered for this position, please email jobs@formulatrix.com with the words "Product Manager - Protein Crystallography" in the subject line. You must include a copy of your resume, (Word, PDF, plain text or RTF only) and answer the following five questions in the body of your email:

  • What attracts you to this job and how do you feel your skill sets will complement the position?
  • What are your salary expectations?
  • When can you start?
  • Are you authorized to work in the United States?
  • Will you now or in the future require sponsorship for employment visa status (e.g., H-1B visa status)?

** NO RECRUITERS OR AGENCIES **


[Post Date: September 21, 2020]


Postdoctoral Position at the NIH on Structural Biology of Noncoding RNAs and RNPs

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Description:

Position Description: A postdoctoral position is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between the accelerated discovery and functional description of the noncoding transcriptome, and the lack of structural and mechanistic understanding of complex noncoding RNAs and RNPs. We seek a new member to join our diverse group to study gene-regulatory riboswitches, highly structured viral RNAs, long noncoding and circular RNAs and their RNP complexes. See https://www-mslmb.niddk.nih.gov/zhang/zhanglab.html for details.

The lab is part of the Earl Stadtman Investigator program for high-risk, high-impact research at the NIH intramural program consisting of 1100 labs. The lab has dedicated access to complete suites of state-of-the-art equipment in structural biology (Mosquito, Dragonfly, Rock Imager, Akta Pures, FSEC, etc., and regular synchrotron access for X-ray crystallography; Titan Krios and Glacios for single-particle Cryo-EM; SAXS, AFM, NMR, etc), cutting-edge biochemistry, biophysics (ITC, DSC, SPR, BLI, AUC, DLS, SEC-MALS, CD, fluorescence, thermophoresis, iSCAMS, etc), fermentation, advanced mass spec, genomics and sequencing, and proteomics core facilities with hands-on training or service by PhD-level staff scientists.

We apply innovative technologies to study RNA and RNP structure, dynamics, and interactions, such as rational RNA design and engineering, RNA cryo-EM, XFEL, ultrafast SAXS/WAXS, single-molecule fluorescence, crosslinking-mass spec., etc. Ongoing projects include structural and mechanistic elucidations of the T-box riboswitches in bacteria and Gcn2 kinase in eukaryotes in cellular stress responses. A second area addresses how numerous viral and host structured noncoding RNAs differentially manipulate immune protein activities such as PKR. For details refer to recent publications:

Suddala K.C & Zhang, J. (2019) High-affinity recognition of specific tRNAs by an mRNA anticodon-binding groove, Nat. Struct. & Mol. Biol., 26, 1114–1122.

Li S. et al., & Zhang, J. (2019) Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions, Nat. Struct. & Mol. Biol., 26, 1094–1105.

Hood, I.V. et al., & Zhang, J. (2019). Crystal structure of an Adenovirus Virus-Associated RNA, Nat. Commun. 10:2871

Incoming fellows are also encouraged to bring your own ideas that you could develop into research programs that you can then take to your independent PI positions. The NIH, NIDDK, and LMB are committed to the continued education and career development of trainees through numerous courses and workshops offered by OITE, FAES, and NIDDK.

Requirements: Interested candidates must have received (or be expecting) a Ph.D. or M.D. within the past five years in molecular biology, structural biology, biochemistry, cell biology, or a related discipline, have excellent oral and written communication skills, and be strongly self-motivated to participate in and design innovative and rigorous research projects. Prior experiences in structural biology are not required.

To apply: Please email a cover letter indicating preferred start date, CV, a brief summary of research interests, accomplishments, and career goals, and names and contact information for at least three references to: Dr. Jinwei Zhang, Email: jinwei.zhang@nih.gov. The NIH is dedicated to building a diverse community in its training and employment programs. DHHS/NIH is an Equal Opportunity Employer.


[Post Date: September 18, 2020]


Position Available - Protein Sciences Specialist

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Description:

The Harvard Medical School Therapeutics Translation is seeking an individual to join its scientific team, in support of our drug discovery effort against emerging pathogens.  The candidate would work collaboratively with several labs at HMS and the affiliated hospitals as a key contributor for ongoing structural biology efforts assisting corona virus related drug discovery programs. This will include solving novel structures of both viral and host proteins and routine co-structures of small and large molecules with their target proteins.  The successful candidate will engage in all aspects of structural biology including protein production, crystallization and structure determination.  The position will be part of an interdisciplinary team, working with design chemists, biochemists, virologists and pharmacologists across several ongoing projects. These team interactions will be both in person, and within the virtual environment.

For more information on the position as well as how to apply, please visit https://bcmp.hms.harvard.edu/news/position-available-protein-sciences-specialist


[Post Date: September 18, 2020]


Job Vacancy: Postdoctoral research fellow position available in Therapeutics Discovery Division at MD Anderson Cancer Center

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Description:

A postdoctoral position is currently available in the Structural Chemistry group, part of the Institute for Applied Cancer Science (IACS) within the Therapeutics Discovery Division of MD Anderson Cancer Center. Our mission is to integrate novel biological insights with drug discovery expertise to accelerate the development of innovative, targeted, small-molecule therapeutics for unmet medical needs. Our work is conducted in a team science environment that brings together excellence in both academic and pharmaceutical discovery, as evidenced by recent publications.

We are seeking a highly motivated individual with a strong background in structural biology, including protein expression and purification, protein crystallization, and X-ray crystallography structure determination. Experience with cryo-EM structure determination and/or structure determination of membrane proteins is not required, but would be advantageous. We are seeking only the most dedicated individuals who will join us in our quest to discover, develop and deliver more effective treatments to our patients. This is a unique opportunity to participate in project-driven drug discovery research within a highly respected academic and clinical setting.

Interested individuals should apply via the Postdoc Jobs website. 

https://www.postdocjobs.com/posting/7069370


[Post Date: September 15, 2020]


Postdoc position in membrane protein strucrual biology at Case Western Reserve University

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Description:

The laboratory of Nami Tajima at Case Western Reserve University School of Medicine is seeking a highly motivated and creative individual with expertise in structural biology and molecular neuroscience/electrophysiology to elucidate the molecular mechanism of ligand-gated ion channel signaling complexes. Our research interests are focused on (i) understanding the regulatory mechanisms of ion channels involved in basic brain functions and neurological diseases, (ii) dissecting the signaling networks/ protein-protein interactions in the context of synaptic signaling, and (iii) structure-based drug discovery. We take an interdisciplinary approach and combined methods from Cryo-EM, X-ray crystallography, electrophysiology, molecular and cellular biology, and biochemistry/biophysics. Case Western Reserve University is equipped with state-of-art structural biology facility including screening microscopes, and a Titan Krios with a K3 camera.

The successful candidate for the postdoctoral researcher must have a recent Ph.D. obtained within three years (or being in the process of completing one) in a relevant field with a demonstrated track record of productive research. Expertise in one or more of the following areas; biochemistry, biophysics, protein expression and purification, cryo-EM, X-ray crystallography, electrophysiology, neuroscience, cell biology, mass spectrometry, and invitro and in vivo fluorescence imaging. Interested applicants should submit (1) a cover letter describing research interests and career goals; (2) a CV; and (3) contact information for 2-3 references by email to Nami Tajima at nxt193@case.edu.

https://physiology.case.edu/people/faculty/nami-tajima/


[Post Date: September 15, 2020]


Postdoc Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA

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Description:

The collaborative Jia-huai Wang and Ellis Reinherz labs at Dana-Farber Cancer Institute and Harvard Medical School are recruiting a postdoctoral fellow to study structural immunology. We use interdisciplinary approaches at the interface of structural, molecular mechanism of cellular immunity with the aim of translating these insights into immunotherapy. Specific research directions include structural and molecular studies of T cell development. The laboratory provides a full access to cutting-edge techniques in molecular biology, protein chemistry, NMR and protein crystallography.

Highly-motivated candidates with a recent PhD or MD/PhD in structural biology and significant experience in molecular biology, biochemistry and immunology are encouraged to apply. Skills in molecular cloning, protein chemistry and crystallography are essential. Candidates should have a publication record in peer-reviewed journals. We are seeking a candidate with excellent writing and communication skills, able to work independently but also effectively with other lab members. Applicants should include a short statement of research goals, CV and three references with their application.

Please contact Dr. Jia-huai Wang at jwang@crystal.harvard.edu.

 


[Post Date: September 10, 2020]


Postdoctoral researcher in Structural bioinformatics, Manstein lab, Dept. Structural Biochemistry, Hannover Medical School (MHH), Germany

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Description:

The project focuses on molecular machines and their role in disease processes. We are looking for a postdoctoral researcher who will support us primarily with molecular dynamics simulations of ligand-induced changes in the conformational dynamics of molecular machines and their complexes. Knowledge in 3D structure determination of protein-protein and protein-ligand complexes is desired.

Our laboratory has state-of-the-art facilities for protein purification, crystallization, imaging and in situ X-ray diffraction of crystals, and dedicated computational resources for structural biology and bioinformatics.

Applicants are expected to have: (1) PhD degree, (2) demonstrated competency in structural bioinformatics, (3) expertise in protein crystallization, X-ray structure determination and structural analysis, (4) willingness to work as part of a collaborative, multidisciplinary team.

Starting date: 1st November 2020 onwards. Please indicate your availability.

Review of applications will begin immediately and continue until the position is filled.

Application: The application should include (compiled in one .pdf file):
(1) a Letter of motivation describing your key expertise and research interests, and
(2) CV with list of publications and contact information for 1-2 referees (or letter of recommendation).

Applications and informal inquiries should be e-mailed to Schille.Joanna@mh-hannover.de with the subject “PDP- Structural bioinformatics”.


[Post Date: September 10, 2020]


Post-doctoral researcher in Structural biology, Salminen lab, Structural Bioinformatics Laboratory, Abo Akademi University, Turku, Finland

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Description:

The project focuses on two medically relevant cell-surface receptors and their multifaceted interactions in inflammation and cancer. The group seeks for a post-doctoral researcher for 3D structure determination of protein-protein and protein-ligand complexes enabling rational development of anti-inflammatory and anti-cancer agents as well as improved tools for imaging inflammation.

Our laboratory has state-of-the-art facilities for protein purification, crystallization, imaging and in situ X-ray diffraction of crystals, and computational resources for structural biology and bioinformatics (https://www.abo.fi/en/structural-bioinformatics-laboratory/).

Applicants are expected to have: (1) PhD degree, (2) demonstrated competency in protein expression and purification strategies using bacterial, insect, and mammalian hosts, (3) expertise in protein crystallization, X-ray structure determination and structural analysis, (4) experience in biophysical methods for analysis of protein interactions, and (5) willingness to work as part of a collaborative, multidisciplinary team.

Starting date: As soon as possible. Please indicate approximate starting date.

Review of applications will begin immediately and continue until the position is filled.

Application: The application should include (compiled in one .pdf file):
(1) a Letter of motivation describing your key expertise and research interests, and
(2) CV with list of publications and contact information for 1-2 referees (or letter of recommendation).
Applications and informal inquiries should be e-mailed to tiina.naumi(at)gmail.com with a subject “Postdoctoral position”.


[Post Date: September 9, 2020]


Postdoc Membrane Structural and Functional Biology – Caffrey Lab Trinity College Dublin, Ireland

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Description:

Post Summary  The Membrane Structural and Functional Biology group seeks to solve the structure of medically important membrane proteins for use in structure/function studies and for structure-based therapeutics development. Target proteins are involved in communicable and non-communicable diseases.

An exciting postdoctoral research position is available in the Group. We are looking for a highly motivated, creative and hardworking individual with experience in biochemistry and molecular biology to join our multidisciplinary team at Trinity in a lab that offers superb facilities. Individuals interested in moving into the membrane protein field are encouraged to apply.

Person Specification  The candidate must have a Ph.D. in biochemistry, biophysics, molecular biology or a related field. Demonstrated success in all aspects of molecular biology, recombinant protein production, purification, and functional characterization is required. Experience with membrane protein over-expression, crystallization, and structure-function studies is desirable. The candidate should be a highly motivated and creative individual who enjoys working as part of a collaborative, multidisciplinary team. Strong leadership, communication and teaching skills are decided assets. A willingness and freedom to travel worldwide on short-term projects is expected.

Salary  €38,631 - €45,942 per annum depending on experience

Closing Date  Until the position is filled

Principal Investigator Prof. Martin Caffrey 

https://www.tcd.ie/Biochemistry/research/caffrey/  

Application Procedure  Candidates are asked to submit a letter detailing education, training and laboratory experience. In the letter, the candidate should outline why they feel they are suitable for the position in an interdisciplinary group that will involve extensive interaction with collaborators and data collection at facilities around the globe. The letter of application must be accompanied by a comprehensive CV to include the names and contact details of two referees (email addresses and phone numbers to be provided). At least one referee should be an individual the candidate has worked with and who has agreed to provide a letter of reference on the candidate’s behalf. 

Applications should be emailed to: msfb789@gmail.com  


[Post Date: September 9, 2020]


Postdoctoral Fellowship in Structural Biology at Uppsala University

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Description:

Opening for a postdoctoral fellow in the Department of Cell and Molecular Biology, Uppsala University.

The project aims to study the structure and function of metal-responsive transcription factors. The successful candidate should have an excellent track record and experience in X-ray crystallography as well as protein expression and purification. Experience of complementary techniques in biochemistry and biophysics would be a benefit.

For more information about the position and how to apply please see the job post on ResearchGate at the link.


[Post Date: September 8, 2020]


Principal/Sr. Scientist, Structural Biology

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Description:

FogPharma is looking for a Principal/Senior Scientist to contribute to the development of helical peptides. We are seeking a highly motivated X-ray crystallographer who will play an integral part of our structure-based drug design effort on multiple programs.  Please apply through the link.


[Post Date: September 8, 2020]


Postdoctoral Position (DNA Repair) – University of Florida, Department of Biochemistry and Molecular Biology

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Description:


The Caglayan lab in the Department of Biochemistry and Molecular Biology, University of Florida seek an outstanding individual with Ph.D. training in biochemistry and/or structural biology to study the DNA repair. The NIH-funded research project will focus on studyinggenome stability, DNA repair, and DNA damage processing (Caglayan M. 2020, Nuc. Acids, Res.; Caglayan M. 2020, DNA Repair; Caglayan M. 2019, J. Mol. Biol., Caglayan M. et al., 2018 Nat. Comm., Caglayan M. et al., 2017 Nat. Comm., Caglayan M. et al., 2014 Nat. Struc. Mol. Biol.) The Caglayan group is in both the Department of Biochemistry and Molecular Biology, and UF Health Cancer Center with investigators renowned for their contributions to the area of biochemistry and cancer biology. The lab utilizes a multi-disciplinary approach to investigate complex biological questions using X-ray structure (structure-function studies), biochemistry, enzymology, and molecular biology.

Minimum Requirements
PhD in a related discipline


Preferred Qualifications
• Experience in purifying recombinant proteins by affinity chromatography methods
(IEX, HIC, SEC) is required.
• Experience in protein-protein and protein-DNA interaction assays (ITC, SPR with Octet
and/or Biacore systems) is essential.
• Experience working with purified proteins and biochemical assays
• Prior experience in enzymology is an advantage (for biochemists).
• Experience in designing constructs for recombinant protein production of
crystallographic studies (X-ray crystallography and/or Cryo-EM).
• Previous working experience with evidence of experimental skills and publication
record with DNA repair is not required, but preferred.


Advertised Salary
The salary for this position is commensurate with experience as determined by NIH guidelines.


How to apply?
To apply, please send Curriculum Vitae, a cover letter, and contact information for three (3)
letters of recommendations to Dr. Melike Caglayan (caglayanm@ufl.edu).

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[Post Date: September 2, 2020]


Description:

A postdoctoral fellowship position is available in the Tsai laboratory at Baylor College of Medicine to investigate the 3D structure, mechanism, and function of ATP-dependent protein quality control machines and related stress-response proteins (Proc. Natl. Acad. Sci. USA 2016; Cell Rep. 2019; J. Mol. Biol. 2019; eLife 2020). Applicants with a Ph.D. in molecular biology, biochemistry or enzymology are encouraged to apply. Demonstrated experience with methods used to express and purify proteins is essential; experience with PCR cloning and site-directed mutagenesis is desired. Prior experience in enzymology or working with a model organism (e.g. bacteria, yeast, worms) is an advantage. The successful applicant will be highly motivated and possess excellent communication skills. S/he will join a multi-disciplinary team that uses systems biology methods to address questions of high biomedical importance. Salary is pegged to the current NIH scale and is in addition to a generous fringe benefit package. To apply, please send a cover letter with research interests and experiences, your current CV, and contact information for three referees to Dr. Francis Tsai (ftsai@bcm.edu).

  • Experience with common statistical methods for data analysis is essential. 
  • Experience with PCR cloning and IEX, HIC, SEC chromatography is required. 
  • Prior experience in enzymology is an advantage (for biochemists). 
  • Prior experience with model organisms is an advantage (for molecular biologists). 
  • Applicants must be able to work independently and as a member of a team.

Applicants with a recent Ph.D. in biological sciences, pharmacology, chemistry, microbiology, or biophysics will be considered if they meet the required criteria. Essential experience is fulfilled by having one first (or co-first) author publication in a reputable peer-reviewed journal. 


[Post Date: September 1, 2020]


Postdoctoral Position

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Description:

Understanding enzyme catalysis by filming enzymes at atomic/fs resolution

Postdoctoral Position

Enzymes are the best performing catalysts on Earth, yet the details of their function — for example what role dynamics play or not in chemical rearrangements — remain a source of debate. New x-ray free electron laser (XFEL) technology allows us to directly image proteins at the time and length-scales (atoms/fs) on which chemistry occurs, making it possible to directly study enzyme catalyzed reactions via imaging. The photobiology group led by TJ Lane at CFEL seeks a postdoctoral candidate conduct this work on naturally occurring and man-made photoenzyme systems.

As the ideal candidate, you will have the following key attributes:

  • A doctoral degree in physics, chemistry, biochemistry, or a related field
  • Excellent wet-lab skills, with knowledge of how to produce, purify, and crystallize proteins
  • A basic familiarity with serial femtosecond crystallography and XFELs
  • Basic computational skills including unix-style environments, python/matlab/similar
  • The ability to drive your work independently and show initiative

And you will be excited to take on the following responsibilities:

  • Design of experiments, including new hardware and software when necessary
  • Organizing and leading teams of 2-20 people to conduct XFEL experiments
  • Preparation of protein crystal samples and wet lab bio/chemistry
  • Interpretation and analysis of experimental results
  • Helping to foster an environment conducive to collaboration, learning, growth, and fun

The position offers a chance to work in a world-leading center in the midst of some of the pioneers of the x-ray laser field. CFEL, DESY, and the broader Science City Bahrenfeld offer an interdisciplinary, collaborative, welcoming, and energizing environment backed by excellently equipped labs, computational and engineering support, and a mindset that no problem is too big to tackle. You will bring your initiative and energy to use these resources and this environment to do great science.

Available immediately is a two year contract with the possibility to extend to three years, with a competitive salary and the opportunity to work and live in the beautiful and vibrant city of Hamburg, Germany.

For more details or to apply, write directly to TJ Lane and provide a CV and short introduction or cover letter.

Understanding and controlling enzyme catalysis through design of photoactive compounds

Postdoctoral Position

Enzymes are the best known catalysts on Earth. The photobiology group led by TJ Lane at CFEL seeks a postdoctoral candidate to develop new chemical technology that will turn regular enzymes into photoenzymes, where the reaction requires light. This enables spatio-temporal control of enzyme chemistry in the biological context, as we can use a laser to initiate the reaction — opening opportunities for learning about how enzymes do their magic both in vitro and in vivo.

As the ideal candidate, you will have the following key attributes:

  • A doctoral degree in chemistry, biochemistry, or a related field
  • Experience working with proteins and biochemical assays
  • Chemical intuition and basic knowledge of organic chemistry and synthesis
  • An undergraduate-level or higher understanding of quantum mechanical principles and how they relate to photochemical behavior
  • The ability to drive your work independently and show initiative

And you will be excited to take on the following responsibilities:

  • Identifying the most important scientific questions in the field of enzyme catalysis
  • Design of experiments, including new hardware and software when necessary
  • Develop new biochemical assays
  • Develop high-throughput screens for new photo-active chemical matter
  • Collaborate with computational chemists to develop new compound designs
  • Helping to foster an environment conducive to collaboration, learning, growth, and fun

The position offers a chance to work in a world-leading center in the midst of some of the pioneers of the x-ray laser field. CFEL, DESY, and the broader Science City Bahrenfeld offer an interdisciplinary, collaborative, welcoming, and energizing environment backed by excellently equipped labs, computational and engineering support, and a mindset that no problem is too big to tackle. You will bring your initiative and energy to use these resources and this environment to do great science.

Available immediately is a two year contract with the possibility to extend to three years, with a competitive salary and the opportunity to work and live in the beautiful and vibrant city of Hamburg, Germany.

For more details or to apply, write directly to TJ Lane thomas.lane@desy.ed and provide a CV and short introduction or cover letter.


[Post Date: August 31, 2020]


Postdoctoral Position

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Description:

Understanding how proteins move by through multi-crystal analysis

Postdoctoral Position

We know proteins make use of long-range motions to perform the essential functions of life: transmit signals, conduct chemistry, and mechanically alter the environment, but how proteins accomplish these amazing tasks remains unexplained at the atomic level. Experimentally measuring these long-range motions at atomic detail has been a challenge. Recently, our group had success in doing this for the main protease (Mpro) from SARS-COV-2, the virus behind the COVID pandemic. Many datasets on COVID and non-COVID proteins have been collected, but new methods are necessary to investigate and extract information about protein motions in these data — we seek a computational scientist to drive this work.

As the ideal candidate, you will have the following key attributes:

  • A doctoral degree in physics, biophysics, computer science, or a related field
  • Excellent computational skills, including python and modern data science methods
  • Capabilities in computational crystallography (serial crystallography a bonus but not required)
  • Knowledge of the principles of protein structure and function
  • The ability to drive your work independently and show initiative

And you will be excited to take on the following responsibilities:

  • Writing software and scripting to perform data analysis on a daily basis
  • Working with large, rich crystallographic datasets from synchrotrons and XFELs
  • Analysis/interpretation of experimental data and results
  • Helping to foster an environment conducive to collaboration, learning, growth, and fun

The position offers a chance to work in a world-leading center in the midst of some of the pioneers of the x-ray laser field. CFEL, DESY, and the broader Science City Bahrenfeld offer an interdisciplinary, collaborative, welcoming, and energizing environment backed by excellently equipped labs, computational and engineering support, and a mindset that no problem is too big to tackle. You will bring your initiative and energy to use these resources and this environment to do great science.

Available immediately is a two year contract with the possibility to extend to three years, with a competitive salary and the opportunity to work and live in the beautiful and vibrant city of Hamburg, Germany.

For more details or to apply, write directly to TJ Lane thomas.lane@desy.de and provide a CV and short introduction or cover letter.


[Post Date: August 31, 2020]


Scientist, Structural Biology

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Description:

TITLE:                  Scientist, Structural Biology

REPORTS TO:     Principal Scientist, Head of Structural Biology

LOCATION:        Cambridge, MA

About Foghorn

Through its Gene Traffic Control™ Product Platform, Foghorn® Therapeutics is discovering and developing an unprecedented class of medicines targeting diseases with genetically determined dependencies in the chromatin regulatory system. The Company, currently pre-clinical stage, is rapidly advancing over 10 programs across a wide range of cancers and is beginning to explore other diseases.

The chromatin regulatory system orchestrates the movement of molecules that turn genes on and off. Disease dependencies associated with chromatin dysregulation are estimated to impact approximately 2.5 million cancer patients in G7 countries and chromatin dysregulation is further implicated in neurological, autoimmune, and other serious diseases. Foghorn’s proprietary Gene Traffic Control Product Platform is based on the Company’s unique insights into the chromatin regulatory system and enables highly scalable drug discovery and development efforts.

Foghorn, a Flagship Pioneering® company, was founded in 2016 by Cigall Kadoch, Ph.D., Gerald Crabtree, M.D., and Doug Cole, M.D., of Flagship Pioneering. Learn more about Foghorn at www.foghorntx.com.

POSITION DESCRIPTION

We are seeking a highly skilled and motivated structural biologist to become an integral member of the Foghorn team. This person will contribute to our goal of developing transformative therapeutics by planning and carrying out structural characterization of crucial drug targets. The main focus of this role will be protein crystallography but will require a willingness to find new ways to think about scientific challenges. We need someone who is passionate, driven, and ambitious to help us achieve our goal of improving patients’ lives.

 

Responsibilities include:

  • Collaborating with colleagues in biochemistry, biology, and chemistry to develop structural biology strategy.
  • Designing biophysics-grade protein constructs and assisting in the optimization of purification protocols.
  • Crystallization, X-ray structure determination, and analysis of important drug targets.
  • Providing regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with medicinal and computational chemists.
  • Participating in the management of collaborations with contract research organizations (CROs) and academic partners.

 

QUALIFICATIONS

  • PhD in Structural Biology, Biophysics, Biochemistry or a closely related field, with a background in chemistry.
  • Demonstrated competency in protein construct design and expression and purification strategies using bacterial, insect, and mammalian hosts. Experience with multi-protein complexes is a plus.
  • Deep expertise in protein crystallization and X-ray structure determination of protein-ligand complexes.
  • Extensive knowledge of protein structure and function, with the ability to articulately communicate structural information to a broad audience.
  • Experience with other structural techniques (e.g. electron microscopy, small-angle X-ray scattering) is strongly preferred.
  • Excellent time management and communication skills.
  • Ability to work in a fast-paced, team-driven environment, with a collaborative and proactive attitude.


[Post Date: August 31, 2020]


Protein Scientist Crystallographer

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Description:

Exscientia is at the forefront of Artificial Intelligence (AI) driven drug discovery and the only company to have designed drug molecules by AI that are in clinical studies. Our mission is to revolutionise the pharmaceutical industry so that patients get faster access to life-saving drugs. Exscientia’s world-class leadership in AI-driven drug discovery has been recognised by partnerships with major pharmaceutical companies, joint ventures with biotech and technology companies and multiple investment rounds by top-tier investors. Exscientia is collectively working to build a cutting-edge future and we’re looking for like-minded individuals to join our journey.
 
Following multiple high-profile partnerships and our most recent Series C fundraise we are now adding a Protein Scientist/Crystallographer to our team.   The Protein Sciences team is part of Discovery Biology at Exscientia and is responsible for enabling small-molecule therapeutic projects by providing GPCR biology, protein production, biophysical and crystallographic capabilities. The team works on diverse target classes to support the transformative efficiency improvements in clinical candidate discovery demonstrated with our systems.  This position is for an experienced scientist specialising in X-ray crystallography, protein expression and purification to join the team and support the discovery of new therapeutic molecules. 
 
We are looking for an excellent Protein Scientist/Crystallographer to add value by being responsible for the crystallization and the structure determination of protein-small molecule complexes by x-ray crystallography. The work will include protein production for structural purposes, crystallization, X-ray data collection, structure determination, and analysis.

What will you be doing in this role?

    • Performing high throughput crystallization experiments on multiple protein targets with and without ligands.
    • Optimizing the initial crystallisation hits to obtain stable reproducible crystal systems.
    • Implementing established techniques of crystal manipulation including ligand soaking, crystal cryo-protection and harvesting.
    • Regular use of synchrotron facilities to execute standard x-ray data collection.
    • X-ray fragment screening experiments within the Diamond XChem pipeline.
    • Expression of proteins in heterologous systems such as E. coli, insect and mammalian cellsas required.
    • Purifying recombinant proteins by affinity chromatography methods.
    • Analysing recombinant proteins.
    • Bringing attention to detail including good record keeping
    • You will author high quality reports and data summaries.
    • Communicate updates to projects.
    • Representing Discovery Biology at scientific meetings.
    • Working to the highest scientific standards under the direction of the Head of Crystallography.

What will you bring to the role?

      • Experience with high throughput crystallisation methods for screening using robotics.
      • Know-how of strategy design for crystal conditions optimization.
      • Skill in crystal manipulation, including soaking, cryoprotection, crystal harvesting.
      • Experience in synchrotron source X-ray diffraction experiments, data collection optimization and beamtime preparation.
      • Proficiency with X-ray data processing, structure solution and refinement.
      • Knowledge of ligand chemical restraints definition and ligand structure refinement.
      • Experience in protein purification and analysis including affinity, ion exchange and size exclusion chromatography, SDS-PAGE and Western blotting and the use of FPLC systems
      • Excellent interpersonal intelligence
      • A demonstrable analytical approach to problem solving
      • The ability to work as part of a team
      • The successful candidate will possess a minimum of a strong honours degree plus either a postgraduate qualification up to a PhD degree or proven industry laboratory experience in the life sciences.

Desirable Experience

    • Understanding of all crystallographic methods (e.g. microbatch)
    • Comprehension of others structural biology techniques (e.g. SAXS and Electron Microscopy).
    • Experience in cell culturing techniques, ideally in both mammalian and insect cell lines.
    • Experience in designing constructs for recombinant protein production of crystallographic targets.
    • Previous work experience in an industrial environment. 

What will you get from us?

    • Making a positive contribution to patients by revolutionising the pharmaceutical industry through AI driven discovery
    • Joining a scaling AI organisation with world class technical and scientific leaders
    • An opportunity to grow your career with us as we grow our organisation
    • We offer a highly competitive compensation to support our employees as we continue to grow and thrive
    • The opportunity to join an inclusive, collaborative and intellectually stimulating culture
    • Working in brand new, state of the art laboratories
    • Modern offices with fantastic free food on offer


[Post Date: August 25, 2020]


Postdoctoral Fellowship - High-resolution structure and function of the multi-layered kidney slit diaphragm

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Description:

About this position

The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organisations in the world. The Headquarters Laboratory is located in Heidelberg (Germany), with additional sites in Grenoble (France), Hamburg (Germany), Hinxton (UK) and Monterotondo (Italy).

The research group of Matthias Wilmanns has a long-standing record in structural biology on research themes that are of medical relevance. Most of our projects require the combined use of different structural biology methods including X-ray crystallography and cryo-electron microscopy, generally followed by functional experiments.

Your role

Project Outline: Ultrafiltration is a key function to maintain body homeostasis, and a major target of hereditary kidney diseases. The slit diaphragm presents the most outer kidney filtration barrier and is of paramount interest to understand the mechanism of kidney filtration both in the healthy human body as well as in patients suffering from its deregulation. We aim to determine the molecular architecture of the underlying protein components and their interactions at high resolution. In this project we will closely interact with an international leading team in the field of kidney research the from University Medical Center Hamburg-Eppendorf (Tobias B. Huber) aiming to directly translate the structural biology work to a better understanding of kidney filtration and kidney disease.

You have

   A PhD in a relevant field

   Proven record of scientific accomplishments

   Previously demonstrated expertise in high-resolution structural biology and biophysical approaches including sample preparation (molecular biology, protein purification)

   Scientific ambition

   International experience

   Openness and interest for interdisciplinary work in collaboration with medical researchers

   Excellent communication skills

You might also have

Additional expertise in biochemistry (in vitro and cell-based assays) and cell biology (including imaging) would be advantageous.

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises from a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family and the availability of an excellent child care facility on campus. EMBL has a large thriving community of bioinformaticians, working in close collaboration with experimental scientists and with strong links to other local scientists and institutions.

What else you need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1600 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.

Informal inquiries should be sent to: matthias.wilmanns@embl.org.

Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.

Please apply online through: www.embl.org/jobs


[Post Date: August 25, 2020]