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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Two Postdoc Positions Newcastle University

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Description:

The Yue lab has recently moved to the Newcastle University Biosciences Institute, and is now up and running! www.staff.ncl.ac.uk/yuelab/

We are currently recruiting two postdoc positions in structure-guided drug discovery.

  1. Want to work on a hit-to-lead translational project in rare metabolic disease, funded by LifeArc & Action Medical Research? Research Associate - Rare Disease Drug Discovery (ncl.ac.uk)
  2. Want to work at the academia-pharma interface, in collaboration with Bicycle Therapeutics, towards rational design of bicyclic peptides? Research Associate in Structure Based Drug Design (ncl.ac.uk)

Both positions (of two years initially) are ideally suited to early/mid-stage structural biologists who are excited by a career in drug discovery (with opportunities to write papers, apply for grants, and disseminate data), and are driven to work in a team and collaborative environment.

Closing date: 8th October 2021

Informal enquiries to wyatt.yue@newcastle.ac.uk


[Post Date: September 16, 2021]


Research Scientist & Postdoctoral Fellow University of Texas Health Science Center San Antonio

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Description:

The Yogesh Gupta research group at the University of Texas Health Science Center, San Antonio, is seeking to hire a Research Scientist and a Postdoctoral Fellow to study the structures and function of RNA modification and chromatin remodeling enzymes. We will use X-ray crystallography, cryo-EM, and enzyme biochemistry to address basic mechanistic questions and develop small-molecule antagonists.

Candidates applying for the Research Scientist position must submit their application using the university's job portal:

https://uthscsa.referrals.selectminds.com/jobs/research-scientist-5175

Candidates applying for the Postdoctoral position can submit their application (CV and brief description of their accomplishments) directly by email: guptay@uthscsa.edu

For detailed information about this position, please use this link: https://gccri.uthscsa.edu/job/postdoctoral-fellow-gupta-lab/


[Post Date: September 16, 2021]


Senior Structural Biologist, X-ray Data Collection - Crystallography

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Description:

Helix BioStructures, LLC (HBS) is a contract research organization based in Indianapolis, Indiana, providing early drug discovery services to the biopharmaceutical industry. HBS maintains a full suite of services that encompass drug design & development, chemical & structural analysis, protein production & purification, and computational modeling & design. HBS’s core and most popular services are structural biology imaging techniques, X-ray Crystallography and Cryo-EM. Founded in 2018 HBS has grown considerably and is currently looking to expand with the aid of an experienced X-ray Crystallographer. This position will be entail working remotely >90% of the time, for the purposes of collecting X-ray data from various Synchrotron beamlines both domestic and international.

Helix’s intent is to fill this position in the next 45 – 60 days if possible, with the likelihood of an initial trial period through contract work (1099-Misc) converting to a full-time position with a benefits package. However, the position could remain flexible provide the right applicant, in this regard. The ideal candidate would have a significant background in X-ray data collection or a general understanding of the X-ray data collection process coupled with substantial related analytical software experience. Presently, Helix is developing in-house crystallographic processing software and the proposed hire will be an integral part of this ongoing effort.

ROLE RESPONSIBILITIES

- Manage X-ray data collection schedule & client bookings.

- Conduct weekly remote X-ray data collection using premier synchrotrons in the US & worldwide.

- Use in-house automated software to reduce raw X-ray data.

- Solve & refine structures either by Molecular Replacement or de-novo

- Document experimental data & communicate research priority, progress, & results with clients & project teams

- Provide technical & scientific guidance to other members within the Structural Biology group

- The candidate will be responsible for completing projects independently and as part of a team and will be responsible for timely updates of the project progress to their supervisor both informally and by formal report writing

-

BASIC QUALIFICATIONS

- Ph.D. in structural biology or related field having 2+ years' postdoctoral experience with crystallography or crystallographic X-Ray data collection in an industrial, academic, or government setting OR

- MS in structural biology or related field having 5+ years’ experience with crystallography or crystallographic X-Ray data collection in an industrial, academic, or government setting.

- BS in structural biology or related field having 7+ years experience with crystallography or crystallographic X-Ray data collection in an industrial, academic, or government setting.

- Experience & proven ability in protein X-ray crystallography from X-Ray data collection to structure solution

- Experience with software for model building & refinement such as Phenix, XDS, CCP4, Chimera, Rosetta, Coot & other commonly used structural biology software packages

- Excellent communication & writing skills, detail-oriented, highly organized, & able to manage multiple tasks & deliver quality data

- Able to work extended shifts (16+ hours) & odd hours (overnight).

PREFERRED QUALIFICATIONS

- Experience with Shelx software package and/or crystallographic software development (AWS, Java, UI)

- Experience with small-molecule X-Ray data collection and/or Small Angle X-Ray Scattering collection / processing

- Experience with Experience with CryoEM grid screening and/or CryoEM data processing and/or structure building/refinement

Job Types: Full-time, Part-time, Contract

Pay: $60,000.00 - $105,000.00 per year

Benefits:

  • 401(k)
  • 401(k) matching
  • Flexible schedule
  • Health insurance
  • Paid time off
  • Retirement plan

Schedule:

  • 12 hour shift
  • Monday to Friday
  • Night shift
  • On call
  • Weekend availability

Supplemental Pay:

  • Bonus pay

Education:

  • Master's (Preferred)

Experience:

  • Python: 1 year (Preferred)
  • SQL: 1 year (Preferred)

Shift availability:

  • Overnight Shift (Preferred)
  • Night Shift (Preferred)
  • Day Shift (Preferred)

Work Location:

  • Fully Remote

Work Location: Remote

Apply at the link, alternatively, please send CV's, references, etc to info@helixbiostructures.com.


[Post Date: September 16, 2021]


Assistant Researcher Senior

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Description:

Position Overview

The Protein Structure and X-ray Crystallography Laboratory (PSXL) is a core laboratory that focuses on the 3-dimensional structure determination of proteins, using X-ray crystallography, for collaborators and manages the structural biology tasks for grant projects. As such, the PSL performs all tasks in the structure determination process including initial construct design, assistance with protein purification, crystallization, X-ray diffraction data collection, structure solution/refinement and structure analysis. The PSL Assistant Researcher Senior will be responsible for assisting with sample purification, setup and monitoring of all crystallization experiments, refinement of crystallization conditions, sample preparation for X-ray diffraction tests, documentation of experimental tasks and preparation of project reports. For further information please see http://psf.cobre.ku.edu/cores/psl/about.
 

Job Description

85% - Conduct research
The PSL Assistant Researcher Senior will carry out and manage crystallization experiments and assist with sample preparation and analysis using X-ray diffraction methods for investigator’s research projects. This includes the monitoring and tracking of all crystallization screening experiments and devising experimental plans for crystal optimization. Additional responsibilities include assisting with protein purification, preparation of protein samples for crystallization experiments and analysis of protein sample quality.

10% - Laboratory supervising
Oversee the daily operations of the PSL crystallization laboratory. This includes maintaining the inventory of consumable supplies, preparing stock solutions for crystallization, general laboratory cleanliness, introducing users to the laboratory guidelines and providing training to users in the area of protein crystallization.

5% - Documentation/Analysis
Responsibilities include: 1) Preparation and analysis of scientific research materials for experiments performed in the PSL, 2) Devising research methods and plans for carrying out purification and crystallization experiments, 3) Maintaining detailed notes and records pertaining to all research work,  4) Writing detailed final reports for investigator’s projects and 5) In some cases co-author publications of research results.

Required Qualifications

1.  Bachelor's degree in a related field and 3 years of related experience OR a Master's degree in the area of relevant field/area of research.

Preferred Qualifications

1.  Experience in any or all of the following:  protein crystallization, protein expression/purification methods, X-ray diffraction methods for single crystals and computational crystallography.

Contact Information to Applicants

Scott Lovell
swlovell@ku.edu

Additional Candidate Instruction

A complete application includes an online application, cover letter, resume highlighting pertinent experience relative to the required and preferred qualifications and contact information for three professional references. Only complete applications will be considered.

Review of applications begins on September 20, 2021.  To ensure first consideration, please apply by September 19, 2021.


[Post Date: September 14, 2021]


Postdoc, Membrane Protein Structural Biology

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Description:

The Position
A Postdoctoral position is available in the Vecchio Lab at the University of Nebraska—Lincoln (UNL) for an NIH-funded project that extends to 2025. The project aims to clarify the structural biology of human membrane proteins and membrane protein complexes involved in epithelial cell/cell adhesion and intercellular transport using X-ray crystallography, cryo-electron microscopy (cryo-EM), microcrystal electron diffraction (microED), and small-angle X-ray scattering (SAXS). The Fellow will be responsible for the expression, purification, and structure determination of these membrane proteins and complexes, which are <100kD. Other activities of the position include assisting with lab organization and operation, student and other personnel training, and grant proposal development and writing, including post-doc fellowships.

The Candidate
Will have a Ph.D. in structural biology, molecular biology, biochemistry, biophysics, or a related discipline. The ideal candidate will have prior experience in membrane protein preparation and handling and one structural biology technique. Such a candidate will be enabled to make immediate and impactful contributions to the lab and field, as we have an established and well-characterized system up and running. The candidate should also possess effective written, verbal, and listening skills.
 
The Lab
The Vecchio Lab is housed in the Department of Biochemistry on the UNL City Campus. We are a 5-member multidisciplinary group with expertise in X-ray crystallography, membrane protein biochemistry and biophysics, and have established collaborators with expertise in cryo-EM, microED, and SAXS. Our technologies include: FSEC, CD, DSC, ITC, MST, BLI, and we have capabilities in detergents, nanodiscs, saposin, amphipols, and SMALPs. The neighboring Structure Core houses an Art Robbins Gryphon robot for VD and LCP crystallization, a CrysCam UV imager with Cy3 filter, 4 incubators ranging from 4-20°C, and an in-house Rigaku X-ray source and detector. We have regular beam time access to the BioCAT SAXS beamline at APS, and SSRL and APS for X-ray diffraction experiments. We also have access to cryo-EM facilities, including the Pacific Northwest Center for Cryo-EM, which possesses 200 and 300 keV microscopes.

About UNL, Lincoln, and Nebraska
UNL is a Carnegie designated R1 Research University (very high), the flagship of the NU system with 26,000+ students, and a member of the Big10 Academic Alliance. Nebraska ranks #9 in The Best States Ranking (US News and World Report) and #17 in America’s Best States to Live In (MSN). Lincoln is Nebraska’s capital, the 2nd most populated NE city and the 70th most populated in the US (320,000 people). Lincoln offers a low cost of living; low unemployment, crime, and poverty rates; great public schools, housing affordability, and bike infrastructure; high quality of life; and wide-open spaces. It’s a fantastic place to raise a family, own a home, go for a bike ride, and maintain a work-life balance. And oh, the sunsets!
 
To Apply
Interested applicants can apply by emailing Dr. Vecchio using “Postdoc: Vecchio Lab” in the Subject. Please send a CV containing contact info for 3 references and a cover letter addressing: 1) reason for applying, 2) past and current research experience, 3) future research/science/career ambitions (non-academic welcome), and 4) training and mentoring expectations. Applications will be reviewed as received until the position is filled.  Deadline November 1, 2021.
 
As an EO/AA employer, qualified applicants are considered for employment without regard to race, color, ethnicity, national origin, sex, pregnancy, sexual orientation, gender identity, religion, disability, age, genetic information, veteran status, marital status, and/or political affiliation. See https://www.unl.edu/equity/notice-nondiscrimination.


[Post Date: September 14, 2021]


Postdoc Albert Einstein College of Medicine

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Description:

Glycans/sugars are the third, and possibly the structurally most diverse, class of biopolymers (next to nucleic acids and proteins). All metazoan cells carry complex glycans on their cell surfaces that are essential for life. We are using the binding patterns of specific immunoreagents (single chain variable fragment antibodies, or scFvs, and nanobodies) against a class of structurally highly diverse glycans called heparan sulfates as a way to characterize (‘glycotype’) mammalian cell types. Preliminary data suggests that this approach allows classification and identification of new cell types as well as differentiation between healthy and diseased cells. For this multidisciplinary, collaborative project between the labs of Drs. Steven Almo, Hannes Bülow, Ulrich Steidl & Deyou Zheng at the Albert Einstein College of Medicine, we are seeking a highly motivated postdoc who is interested in working at the interface of protein engineering, structural biophysics and glycan biology to study the logic of protein-sugar interactions of the heparan sulfate-specific scFvs with their sugar binding partners. Prior experience in protein structural biology is a plus but not required; interest in sugars and proteins is a must! Candidates should send their research statement, CV, and the names and contact information for three references to steve.almo<AT>einsteinmed.org


[Post Date: September 14, 2021]


Scientist I – Structural Biology ( X-ray crystallography)

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Description:

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public’s interest.  

 Position Overview:

PROGRAM DESCRIPTION

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

KEY ROLES/RESPONSIBILITIES

Scientist I – Structural Biology

  • The candidate will join the structural biology group within the RAS initiative and will be responsible for the crystallization and the structure determination of protein-small molecule and protein-protein complexes by X-ray crystallography
  • The work will include construct design, biochemical and biophysical characterization, crystallization, X-ray data collection, structure determination, and analysis
  • The candidate will work closely with protein scientists, biophysicists, and protein NMR scientists as part of an integrated structural biology effort
  • The candidate will be a member of the drug discovery team, working closely with computational and medicinal chemists on structure-based drug design approaches for small molecule agent optimization. The candidate will be expected to be able to participate in experimental design and to conduct experiments in a priority-driven environment independently
  • The candidate will be responsible for completing projects independently and as part of a team and will be responsible for timely updates of the project progress to their supervisor both informally and by formal report writing
  • Work requires the use of personal protective equipment and adherence to strict safety protocols

BASIC QUALIFICATIONS

  • Possession of a PhD degree in structural biology, protein biochemistry/biophysics, crystallography, or in a related discipline from an accredited college or university, according to the Council for Higher Education Accreditation
  • Proven ability in all aspects of protein crystallography from construct design through structure determination and analysis
  • Experience in the crystallization of protein-small molecule and protein-protein complexes
  • Expertise in commonly used structural biology software packages
  • Proficiency in protein biochemical and biophysical assays
  • Excellent communication and witting skills
  • Detail-oriented, highly organized and able to manage multiple tasks and deliver quality data
  • Must be able to obtain and maintain a clearance

PREFERRED QUALIFICATIONS

  • Experience in analyzing protein small-molecule interaction using isothermal titration calorimetry (ITC), differential scanning fluorimetry (DSF), and NMR techniques
  • Knowledge of mechanistic enzymology, and protein chemistry

JOB HAZARDS

  • This position is subject to working with radioactive material and requires to become an approved radiation worker

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)


[Post Date: September 8, 2021]


Biochemistry Assistant Professor Department of Chemistry and Biochemistry at The Ohio State University

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Description:

Department: Chemistry and Biochemistry 

Positions: Biochemistry

Rank: Assistant Professor

Description: The Department of Chemistry & Biochemistry in the College of Arts and Sciences at The Ohio State University seeks to fill two tenure-track faculty positions at the Assistant Professor level in the general area of biochemistry. This search is open to candidates with expertise in all areas of biochemistry, including structural, chemical and molecular biology. The new faculty members will join an interdisciplinary community on the main campus in Columbus, Ohio. Our partners - Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Nationwide Children’s Hospital, Center for Electron Microscopy and Analysis (CEMAS), and the Ohio Supercomputer Center - offer limitless opportunities for collaboration and advancement of research programs. In particular, CEMAS houses a F20, 200 keV Glacios microscope with falcon detector and autoloader and a 300 keV Titan Krios with K3 detector and energy filter. Departmental faculty also have access to state-of-the-art on-campus facilities for genomics, mass spectrometry, NMR spectroscopy and X-ray diffraction.

Qualifications: A Ph.D. in Chemistry, Biochemistry or a related field is required. The position will begin Autumn 2022. Demonstrated excellence in innovative research and a strong commitment to teaching are essential. Outstanding applicants in all areas of biochemistry will be considered but priority will be given to those candidates whose research interests complement those of existing faculty. As a campus with a diverse student body, we encourage applications from women and other underrepresented minority groups. Appointment is contingent on the university’s verification of credentials and other information required by law and/or university policies, including but not limited to a criminal background check.

About Columbus: The Ohio State University campus is located in Columbus, the capital city of Ohio. Columbus is the Midwest’s fastest growing city and the nation’s 14th largest city. Columbus offers a diverse array of welcoming neighborhoods and a vibrant arts and culture scene. Additional information about all that the Columbus area has to offer is available at https://visit.osu.edu/experience.

Application Instructions: Apply to Academic Jobs Online at: https://academicjobsonline.org/ajo/jobs/19039. A complete application consists of a cover letter, curriculum vitae, research, teaching, diversity statement, and three letters of reference. The diversity statement should articulate your demonstrated commitments and capacities to contribute to diversity, equity, and inclusion through research, teaching, mentoring, and/or outreach and engagement. Review of applications will begin on September 15, 2021 and will continue until the position is filled. Inquiries may be directed to Prof. Karin Musier-Forsyth, Search Committee Chair at musier-forsyth.1@osu.edu.

The Ohio State University is committed to establishing a culturally and intellectually diverse environment, encouraging all members of our learning community to reach their full potential. Over the next few years, The Ohio State University is committed to welcoming 350 new faculty hires, many of which will contribute to growing our role as a premier research university equipped to answer and interrogate the critical domestic and global societal challenges that deter equality and inclusion. We are responsive to dual-career families and strongly promote work-life balance to support our community members through a suite of institutionalized policies. The university is a member of the Ohio/Western Pennsylvania/West Virginia Higher Education Recruitment Consortium (HERC).

The Ohio State University is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation or identity, national origin, disability status, or protected veteran status.


[Post Date: September 3, 2021]


Postdoc University of California San Francisco

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Description:

A post-doctoral position is available in the laboratory of Dr Robert Stroud at the Mission bay campus of the University of California San Francisco (UCSF). (https://msg.ucsf.edu/people/robert-stroud-ma-phd). Research in the group is focused on the structure and mechanisms of transmembrane processes, and particularly in this position on the mechanisms of neurotransmitter packaging into synaptic vesicles in the brain. These provide for the ‘quantal release’ in neuronal signaling. Structures are determined by Cryo-electron microscopy, Cryo-electron tomography, X-ray diffraction as inroads to defining the structural basis of function. Example see (https://www.ncbi.nlm.nih.gov/pubmed/32439795). Experience in cryo-EM and any of these areas is an advantage. First rate facilities are available in a highly cooperative environment. NRSA postdoctoral stipend levels+benefits. If interested please send a brief cover letter, CV and contact information for three persons who might provide references to stroud@msg.ucsf.edu   Application open until October 15 2021.


[Post Date: September 3, 2021]


Beamline Scientist - XFEL Hub

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Description:

About Us

Diamond Light Source is the UK’s national synchrotron science facility. By accelerating electrons to near light-speed, Diamond generates brilliant beams of light from infra-red to X-rays which are used for academic and industry research and development across a range of scientific disciplines including structural biology, physics, chemistry, materials science, engineering, earth and environmental sciences.

About the Role

The XFEL Hub at Diamond Light Source is seeking a Beamline Scientist for a full time, permanent position. This person will help with the activities of the Hub and its mission to enable and promote dynamic structural biology at Diamond and at X-ray Free Electron Lasers (XFELs). To this end, the Hub is developing tools and methods to enable time-resolved serial crystallography experiments conducted at near-physiological temperatures, especially at XFELs but also at Diamond MX beamlines. We are also working to develop freeze-quench strategies to trap reaction intermediates for analysis by complementary approaches including structural and spectroscopic methods. The scientist will help the XFEL Hub execute a variety of R&D plans, which when successful, will yield robust and routine time-resolved serial crystallography strategies/results at Diamond, Diamond II, and at XFEL facilities. The candidate will also peruse R&D projects that are complementary to the mission of the Hub.

The position will very likely include international travel to XFEL facilities in the USA (LCLS), Japan (SACLA), South Korea (PAL-XFEL), Switzerland (SwissFEL) and Germany (European XFEL) for data collection along with members of the Hub and the international research community.

About You

Excellent interpersonal communication skills, an ability to collaborate in large and complex groups, as well as adherence to best scientific practices are all vital to the position.

Prior hands-on experience with macromolecular crystallography at a synchrotron is required. Serial synchrotron crystallography experience is highly desirable.

Serial femtosecond crystallography (SFX) experience at an XFEL facility is not strictly required but is highly desirable. Moreover, the direct hands-on XFEL experience with time resolved SFX methods at one or more XFEL facilities is ideal.

Benefits

Diamond offers an exceptional benefits package to support staff in achieving a positive work/life balance. This includes 25 days annual leave plus 13 days of statutory and company holidays, along with flexible working hours and an excellent pension scheme. Staff also have access to a range of amenities on site including a nursery, cafes, a restaurant and sports and leisure facilities. A relocation allowance may also be available where applicable.


[Post Date: September 3, 2021]


Post Doctoral Fellow - Biochemistry

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Description:

Discover Your Career at Emory University

Emory University is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the future. We welcome candidates who can contribute to the diversity and excellence of our academic community.

Description

The Post Doctoral Fellow helps design and conduct research within a specified field while receiving advanced training from a designated Principal Investigator to enhance professional skills and research independence needed for pursuit of a career.

 

JOB DESCRIPTION:

  • The specific area of research in which the trainee is mentored is determined by the department and laboratory of the Postdoc.
  • Designs and evaluates experiments.
  • Develops new ideas that promote current research.
  • Prepares and publishes scientific manuscripts under the direction of the Principal Investigator.
  • May be responsible for operation of specific equipment.
  • May teach techniques to others, train, and supervise research staff.

ADDITIONAL JOB DETAILS:

  • Positions are temporary appointments as a research trainee.
  • The initial appointment is for one year, renewal expected if progress is satisfactory and funds are available.
  • Appointments cannot exceed five years.

A qualified applicant should hold a Ph.D. or expect to hold a Ph.D. within or around one year in the area of biochemistry, structural biology, biophysics.

 

MINIMUM QUALIFICATIONS:

  • A doctoral degree or equivalent (Ph.D., M.D., ScD., D.V.M., DDS etc) in an appropriate field.
  • Excellent scientific writing ability and strong oral communication skills.
  • The ability to work effectively and collegially with colleagues.
  • Additional qualifications as specified by the Principal Investigator.
  • The applicant should have experiences in molecular biology, cell culture, protein expression & purification, and biochemistry.

NOTE: Position tasks are generally required to be performed in-person at an Emory University location.  Remote work from home day options may be granted at department discretion. Emory reserves the right to change remote work status with notice to employee.


[Post Date: September 3, 2021]


Postdoctoral Position in Structural Biology

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Description:

Postdoctoral Position in Structural Biology

Dr. Jakub Gruszczyk team is looking for a talented Postdoctoral Fellow with an experience in protein crystallography and/or single particle cryo-electron microscopy. The researcher will contribute their expertise to support ongoing collaborative projects aiming at structural and biochemical characterisation of the aryl hydrocarbon receptor-dependent signalling pathway. The Postdoctoral Fellow will be involved in managing their own independent research project within the main research focus areas of the host team.

Your responsibilities

  • Preparation of DNA constructs for protein production in different expression systems
  • Heterologous protein expression using bacterial, insect and mammalian cells
  • Protein purification using Akta chromatography system
  • Protein crystallisation, diffraction data collection and structure solution
  • Cryo-EM sample preparation, single particle cryo-EM data collection, 3D reconstruction, map refinement and model building
  • Development of biochemical and biophysical assays to validate structural data
  • Preparation of manuscripts for publication
  • Participation in training interns and students

Your profile

Excellent theoretical knowledge and practical skills in either X-ray crystallography or cryo-EM are required. The ideal candidate will have a strong background in protein crystallography, cryo-EM, biochemistry, protein purification and molecular biology. Proficiency in using different chromatographic techniques is compulsory. Previous experience with large size multi-protein complexes is highly desired. Knowledge of cell culture is a plus. The successful applicant must have a PhD in structural biology and at least two years of Postdoctoral experience in similar position. A proven track record of publications in high quality journals is mandatory. Excellent oral and written English as well as the ability to communicate ideas and work collaboratively as a member of a highly motivated team are essential.

What we offer

Two-year contract and salary commensurate with previous research experience.

The Postdoctoral Fellow will have access to the synchrotron facilities at ESRF and Soleil as well as to Titan Krios microscope through collaboration with University of Leicester, UK.

Place of work

Centre for Structural Biology (CBS) in Montpellier specialises in many different techniques including nuclear magnetic resonance, X-ray crystallography, electron microscopy, advanced fluorescence microscopies and single molecule manipulation. The diversity of the expertise present on the same site, together with the strong network of local, national and international collaborations, allow us to tackle even the most ambitious scientific projects.

Montpellier is situated in the southern France. The city enjoys a typical Mediterranean climate with hot and sunny summers and relatively mild winters. The location, including proximity of large cities like Marseille and Barcelona, makes Montpellier an exciting place to live and work.

Beginning of employment

Preferably before 1st of January 2022.

Application

The application, including CV, cover letter and the names of 2-3 references, should be sent to Jakub Gruszczyk (jakub.gruszczyk@cbs.cnrs.fr).  Application deadline Setepmber 24, 2021.


[Post Date: September 1, 2021]


Postdoc Protein Interaction Engineering, Birkbeck College, London UK

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Description:

Postdoctoral position in Protein Interaction Engineering to join the EU MOSBRI project mosbri.eu based at Birkbeck, University of London

To carry out research in the field of the molecular biophysics of protein-protein interactions in order to create new reference standards for biophysical measurements. This research is a key aim of the new European Molecular-Scale Biophysics Research Infrastructure (MOSBRI – https://www.mosbri.eu/).

The post-holder will design, make and evaluate a variety of single and multi-domain proteins; characterizing their interactions using a wide-range of biophysical methods (including spectroscopy, calorimetry and light scattering). A number of systems will be studied, but the focus will be on engineering the protein-protein interactions of TPR (tetratricopeptide repeat) domains. The primary aim is to use a repeated design-build-test strategy to engineer interacting partner proteins that have close to ideal behaviour in terms their affinity, solubility, stability and suitability for study by multiple biophysical methods. The secondary aim is to create well-behaved experimental model systems to assist the development of new methods of analysis of complex equilibria, such as occur in coupled folding-binding reactions and in systems with multiple binding sites.

It is anticipated that the successful applicant will have substantial experience in recombinant protein expression and purification and knowledge of protein structure and protein interaction measurement. While a strong biophysics background would be an advantage, it is not essential, and post offers the possibility to train in multiple biophysical techniques in the context of a supportive network of experts across the 15 MOSBRI partner institutes.

The post is based in the ISMB Protein Crystallography and Biophysics Centre at Birkbeck (BiophysX - https://biophysics.ismb.lon.ac.uk/ ). The work is funded by the EU Horizon 2020 program and will contribute to MOSBRI’s goals of developing international standards for biophysical experiments, data analysis and sharing. The post-holder will work with colleagues at other MOSBRI partners, particularly those at the Institute Pasteur (Paris) and the scientific data analysis company Affinimeter (Santiago de Compostela) https://www.affinimeter.com, and with collaborators at the University of Manchester in order to achieve these goals.

Remuneration:

Grade 7 of the College's London Pay Scale which is £39,173 rising to £44,775 per annum.

The salary quoted is on the College's London Pay Scale which includes a consolidated Weighting/Allowance which applies only to staff whose normal contractual place of work is in the Greater London area.

Enquiries:

If you would like to know more about the role, please click on apply below or contact the ISMB BiophysX Centre Director - Dr Mark A. Williams  ma.williams@bbk.ac.uk

If you have technical issues or difficulties using the recruitment portal please contact jobs@bbk.ac.uk, providing your name and the job reference number of the position.

While we are happy to respond to all informal enquiries, only formal applications through the online system will be considered.

 
Closing date for applicants 03-Oct-2021.

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[Post Date: September 1, 2021]


Tenure-Track Faculty Position Vanderbilt University

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Description:

Vanderbilt University invites applications for a tenure-track, faculty position in evolutionary biochemistry at the Assistant Professor rank. Investigators that apply experimental, engineering, and/or computational approaches to understand a) how proteins or other structural and catalytic features of cells evolve or b) how metabolic pathways evolve are particularly encouraged to apply. The selected candidate will join the Department of Biological Sciences (https://as.vanderbilt.edu/biosci/) and the Vanderbilt Evolutionary Studies Initiative (https://www.vanderbilt.edu/evolution/), with opportunities for a dual appointment in the Department of Chemistry (https://www.vanderbilt.edu/chemistry/) and affiliation with the Department of Biochemistry (https://medschool.vanderbilt.edu/biochemistry/) and the Center for Structural Biology (https://www.vanderbilt.edu/csb/).

The candidate will be expected to develop an independent laboratory research program that complements current departmental and institutional strengths in evolution, biochemistry, genome science, biophysics, cell and molecular biology, chemical biology, synthetic chemistry, drug discovery, computational biology, host-microbe interactions, and neurobiology. As a new faculty member, the candidate will play an integral role within the trans-institutional Vanderbilt Evolutionary Studies Initiative and will benefit from collaborations with diverse internationally recognized programs, centers, and institutes. Top candidates will demonstrate excellence in research, highly effective teaching and mentoring to undergraduate and graduate students, and a desire to contribute to a collaborative academic community. Applicants must have earned a Ph.D. no later than August 16, 2022, and preferably one or more years of postdoctoral research experience. Applicants should submit: (a) a letter of interest, (b) full curriculum vitae, (c) a statement of research interests, (d) a statement of teaching philosophy, and (e) a statement of equity, diversity, and inclusion directly to http://apply.interfolio.com/93130. Applicants should arrange for at least three letters of recommendation to be sent to the same link. Completed applications must be received no later than October 15, 2021.

Vanderbilt University is an Equal Opportunity/ Affirmative Action employer, embraces diversity and inclusion, and has a strong institutional commitment to recruiting and retaining an academically and culturally diverse community of faculty and to teaching students who are diversified by gender, race/ethnicity, and other social locations. Minorities, women, individuals with disabilities, and members of other underrepresented groups are strongly encouraged to apply. Vanderbilt University ranks in the top 15 National Universities and is located in the heart of Music City, Nashville, TN. Nashville is consistently rated as a great place to live (https://www.vanderbilt.edu/nashville/).


[Post Date: September 1, 2021]


Postdoc University of Liverpool Cardiovascular & Metabolic Medicine

View the Job Posting Here

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Description:

University of Liverpool - Department of Cardiovascular and Metabolic Medicine

Location:

Liverpool

Salary:

£34,810 to £40,322 p.a.

Hours:

Full Time

Contract Type:

Fixed-Term/Contract

Placed On:

25th August 2021

Closes:

21st September 2021

Job Ref:

033448

We are looking for an enthusiastic Post-doctoral Research Associate to join the team of Dr Nordine Helassa on a 3-year British Heart Foundation funded project. Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease that can cause life-threatening cardiac arrythmias. It is the most common cause of sudden death in the young and is characterised by ventricular hypertrophy and contractile dysfunction. HCM has been associated with mutations in genes mostly encoding sarcomeric proteins such as myosin, tropomyosin and troponins. However, the detailed molecular mechanism leading to the clinical phenotype remains unclear. The project aims to determine the role of disease-associated troponin I mutations in cardiac dysfunction using a multidisciplinary approach combining protein biophysics, structural biology and muscle physiology.

You will have (or have already submitted) a PhD in structural biology, biochemistry, biophysics, biological sciences or a closely allied discipline. Laboratory experience with recombinant protein expression/purification techniques and structural biology (X-ray and/or NMR) would be advantageous. The post is available until 30 November 2024.

For full details and to apply online, please visit: https://recruit.liverpool.ac.uk


[Post Date: August 30, 2021]


Postdoctoral Fellow Position for Structural Neuropharmacology at CSHL

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Description:

The Furukawa lab at Cold Spring Harbor Laboratory (CSHL) has a postdoctoral fellow position opening for a scientist with a strong background in structural biology and biochemistry. We work on ion channels and membrane protein complexes involved in the neurobiology of learning/memory, neurological disease/disorder, and neuron-cancer interfaces. We implement cryo-EM, x-ray crystallography, electrophysiology, protein engineering, and cellular imaging to address the above questions.

CSHL is equipped with a Titan-KRIOS electron microscope/K3 direct electron detector and has convenient access to the NSLS-II synchrotron beamlines (AMX and FMX). CSHL has solid core facilities including antibody production, neuro/cancer imaging, CRISPR/RNAi, animal, etc. We offer a unique training environment for research and career development. In addition, the CSHL Meetings and Courses program provides an opportunity for interacting with a broad range of researchers. Please visit http://furukawalab.labsites.cshl.edu/ for more details on research, publication, mentoring/lab culture, and training track record before you apply.

For this search, we prioritize scientists with strong backgrounds in cryo-EM, x-ray crystallography, and/or biochemistry. Experience in structural analysis is desired but not required. A qualified applicant should hold a Ph.D. or expect to hold a Ph.D. within or around 1 yr in the area of biochemistry, structural biology, biophysics, etc.

Please send a CV and a cover letter briefly describing current research and future research interests in our lab directly to Hiro Furukawa at furukawa@cshl.edu.


[Post Date: August 30, 2021]


Principal Research Scientist-Structural Biology

View the Job Posting Here

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Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

The Discovery Chemistry & Technologies organization within Lilly Research Laboratories is a diverse and dynamic group seeking a highly skilled scientist to join the structural biology team. We support drug discovery for numerous innovative projects and are looking for someone to inspire change in the drug hunting process. The primary focus will be to lead in the development and deployment of methodologies to accelerate structure based drug design. Broad experience with proteins, along with a proven track record of structural determination is required. We are a diverse team of scientists and strive for excellence and innovative solutions to find therapies for our patients. Join our team today and make an impact!

Do you have experience leading and collaborating in a team environment? Consider joining Lilly today help to make a difference in our purpose and communities we serve!

Responsibilities for the position

  • Provide structure-based drug design leadership and support by multiple methods for a broad range of targets across different therapeutic areas
  • Determine structures and co-structures of novel protein targets and analyze pertinent data for the rational design of both small-molecule and antibody therapeutics
  • Partner closely with other structural biologists, biophysicists, protein biochemists and medicinal chemists to develop integrative approaches and address specific project needs and challenges
  • Collaborate on multidisciplinary teams designing novel therapeutics, presenting scientific data in support of drug discovery projects

Basic Qualifications

Ph.D. in Structural Biology, Biophysics, Biochemistry, Chemistry or other relevant field with 5+ years of experience in the field of structural biology and structure-based drug design is required

Additional Skills/Preferences

  • Experience in both X-ray crystallography and cryo-EM is advantageous
  • Prior industry experience and a strong publication record is highly preferred
  • Flexibility to work in an environment with constantly evolving priorities and completion timelines, with strong interpersonal, written & verbal communication, and problem-solving skills
  • Strong capability to collaborate with scientists in multiple fields and to mentor staff scientists in drug discovery; experience leading teams focusing on structural biology efforts
  • Familiarity with other biophysical methods (E.g., MS, bioNMR, SPR, BLI, etc.) would be helpful
  • Experience in scientific programming (Python, C, C++) and an interest in protein dynamics is a plus
  • This position can be located in Indianapolis, IN or San Diego, CA

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

To submit resume, visit https://www.lilly.com/careers and apply to Req ID R-16332.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


[Post Date: August 25, 2021]


Postdoc University of Southern California (USC) School of Pharmacy

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Description:

The University of Southern California (USC) School of Pharmacy seeks a Postdoctoral Researcher to join the laboratory of Dr. Paul Seidler in the Department of Pharmacology & Pharmaceutical Sciences.  The focus of this budding laboratory is on Alzheimer’s Disease drug development.  The successful candidate will have the opportunity to shape the laboratory alongside the PI.  The primary roles of the Postdoctoral Researcher will be focusing on the CryoEM structure determination of small molecule inhibitors in complex with brain-derived fibrils of the protein tau. Additional focus will be on the conjugation and analysis of activity and specificity of nanoparticle complexes with drug-like molecules, and the physical effects these nanoparticles have on protein aggregation and the blood-brain-barrier.  Assays include a battery of in vitro and cell-based screens and the development of mass spectrometry approaches to assess small molecule binding sites on amyloid-like protein fibrils.    

As part of their training and research, the candidate can expect regular interactions with the PI, members of the USC Centers for NanoImaging (CNI), Advanced Research Computing (CARC), and Mass Spectrometry, which is housed at the USC School of Pharmacy.  Additional interactions are expected with local collaborators at the University of California Los Angeles (UCLA) Departments of Pathology and Chemistry.    

Desired scientific qualifications include a Ph.D. in Biochemistry, Biophysical or Structural Biology, Chemistry, Materials Sciences, Bioengineering, or related fields of study.  Experience with negative-stain and cryo-electron microscopy is highly desired, as is experience with protein purification, nanoparticle chemistry, and biochemical and cell-based assay development.  The candidate should exhibit excellent communication and documentation skills in order to advance projects in cooperation with other lab members and collaborating labs.    

Interested applicants may submit the following directly to Dr. Seidler at pseidler@usc.edu 

  1. Curriculum Vitae
  2. Statement of research experience and interests
  3. Names and contact information for three references

The USC School of Pharmacy is located downtown L.A. and is the largest private employer in the City of Los Angeles. As an employee of USC, you will be a part of a world-class research university and a member of the "Trojan Family," which is comprised of the faculty, students and staff that make the university what it is. 

USC is an equal opportunity, affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other characteristic protected by law or USC policy. 


[Post Date: August 24, 2021]


Postdoc The University of British Columbia in Vancouver, Canada

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Description:

 A postdoctoral position is available immediately to work on ion channel structural biology in the lab of Filip Van Petegem, Department of Biochemistry and Molecular Biology.

The project combines X-ray crystallography, cryo-EM, and electrophysiology. Our lab has steady access to the in-house X-ray and cryo-EM facilities: 

- Microscopes: 300kV Titan Krios with Falcon IV detector and Selectris Energy filter.   A 200kV Glacios (Falcon III detector) is available for prescreening grids.

- X-ray equipment in the lab includes Mosquito and Dragonfly robotics, and we have regular access to an in-house X-ray diffractor (Rigaku Micromax-007 HF with Saturn 744+ CCD detector) and various synchrotron beamlines

Minimum requirement for applicants include a PhD in Biochemistry or a related discipline with extensive experience in either X-ray crystallography or cryo-EM, as well as protein expression and purification.  Direct experience with membrane proteins is an additional plus.

The lab values diversity and inclusivity, and applicants from all backgrounds are encouraged to apply. This is an opportunity for people with structural biology expertise to learn electrophysiological methods.

Recent work from the lab includes an investigation of how Ryanodine Receptors are modulated by small molecules, disease mutations, and post-translational modification, using cryo-EM, X-ray crystallography, planar lipid bilayer electrophysiology, and enzyme kinetics.

Woll et al (2021) Nature Comm. 12:807

Ma et al (2020) Nat Chem Biol. 16,1246-1254

Haji-Ghassemi et al (2019) Molecular Cell 75,1-14

For more information on recent work, see http://crg.ubc.ca/VanPetegem/

The lab is housed within the Life Sciences Centre at UBC (lsi.ubc.ca), located on the Point Grey campus in Vancouver.

Interested candidates should send a CV, along with names and contact details for 3 references to filip.vanpetegem@gmail.com.


[Post Date: August 23, 2021]


Postdoc University of Manitoba

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Description:

A postdoc position is available in my lab to study the structural biology of infectious and genetic diseases.  Projects with crystals in-hand are available in two areas:  1) Inhibitor design projects targeting coronavirus proteases and proteases of related viruses, 2) Structure/function studies of lysosomal enzymes involved in genetic disease and the development of pharmacological chaperones to rescue their function.  For those with Cryo-EM experience, an additional project focused on understanding the structural biology of large viral polymerases is also available. Our lab has access to in-house X-ray diffraction instrumentation (Rigaku), on-going access to synchrotron sources including the Canadian Light Source, and a new in-house Talos F200C Cryo-EM outfitted with a Falcon 4 direct electron detector.  Additional information about our research and recent publications can be found at: http://home.cc.umanitoba.ca/~bmark/Welcome.html
 
Enthusiastic individuals who hold a PhD in biochemistry or related field are encouraged to apply. Candidates should have a strong background in molecular biology and protein X-ray crystallography. Experience in Cryo-EM would be an asset given projects available.
 
We are in the Department of Microbiology, University of Manitoba, Winnipeg, Canada. The University of Manitoba (http://umanitoba.ca/) hosts over 30,000 students, faculty, and staff and has a dynamic biomedical research community.  Winnipeg is a vibrant, multicultural city with numerous cultural events and festivals (https://www.tourismwinnipeg.com).
 
Salary will be in accordance with Canadian Institutes of Health Research (CIHR) (http://www.cihr.ca/ ) standards and includes a university staff benefits package.
 
All qualified candidates are encouraged to apply.
 
Please email inquiries and CV's (including names of three referees) to Brian Mark (brian.mark@umanitoba.ca).


[Post Date: August 18, 2021]


Postdoc University of Texas Health Science Center at San Antonio

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Description:

The lab of Dr. Yogesh Gupta at the University of Texas Health Science Center at San Antonio http://ccri.uthscsa.edu/YGupta.html is seeking an enthusiastic Postdoctoral Fellow to work on an NIH-funded project on SARS-CoV-2 and RNA modification. We will use X-ray crystallography, cryo-EM, and cell-based methods to address basic mechanistic questions and develop novel antivirals.

These two papers describe our most recent work on SARS-CoV-2.

Nature Communications. 2021 Jun 2; 12: 3287. PMID: 34078893. DOI: 10.1038/s41467-021-23594-y

Nature Communications. 2020 Jul 24;11(1):3718. PMID: 32709886. DOI: 10.1038/s41467-020-17496-8

Preference will be given to applicants with demonstrated experience in purification and structural characterization of protein-nucleic acid complexes by X-ray crystallography with a strong interest in learning cryo-EM. An ideal candidate should hold (or soon expect to hold) a Ph.D. or equivalent degree in biochemistry/biophysics/structural biology and have no more than 3 years of postdoc experience. Salary is competitive and commensurate with experience.

San Antonio is the nation’s seventh-largest city and is located at the edge of the beautiful Texas Hill County. San Antonio offers a rich, multi-cultural community, affordable cost of living, excellent weather, and a thriving biomedical industry. There is no state income tax in Texas. All Postdoctoral appointments are designated as security-sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Opportunity/Affirmative Action Employer, including protected veterans and persons with disabilities.

If interested in applying, please send a short description of your research accomplishments and a CV with contact information of 3 references to Dr. Yogesh Gupta (email: guptay@uthscsa.edu).

 


[Post Date: August 17, 2021]


Postdoctoral Associate Stony Brook University

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Description:

​Required Qualifications  (As evidenced by attached resume):

Doctoral Degree  (foreign equivalent or higher degree) in biochemistry, biophysics, molecular biology, plant biology or closely related field in hand by October 2021.

Preferred Qualifications:   
Experience in protein expression using bacterial, yeast, insect, or mammalian cells. Experience in transient gene expression in Nicotiana benthamiana leaves. Experience in purification of proteins and their complexes. Experience in enzyme activity assays. Experience in biological crystallography and diffraction data analysis. Experience in cryo-EM sample preparation, data collection and analysis. Experience in antibody development using phage or ribosome display.

Brief Description of Duties:  The Postdoctoral Associate will assist  Dr. Liu  in the Department of Biochemistry and Cell Biology at Brookhaven National Laboratory.  The incumbent will conduct research and ensure that all experiments are appropriately conducted following the policies and procedures of Brookhaven National Laboratory, Upton New York. the incumbent should have the ability to communicate effectively.

  • Within the predetermined research scope and methodology, conduct research experiments in the field of structural biology.
  • Collect and analyze data, including periodical/literature search and utilizing specialized skills in related fields to analyze the collected data.
  • Participate/assist in manuscript writing for publication in scientific journals and/or presentations.  May also assist in grant writing.
  • Lab maintenance, including equipment maintenance and ordering of supplies as needed.
  • Other duties as assigned, which may include attending Scientific Conferences and Meetings.


[Post Date: August 17, 2021]


Postdoctoral Associate - Kuriyan Lab

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Description:

We are currently looking for a creative, motivated, and highly skilled Postdoctoral Associate to work in the laboratory of Dr. John Kuriyan at the University of California, Berkeley. The Kuriyan lab studies the mechanisms, evolution, and structures of the molecular switches that carry out cellular signal transduction. They use biochemical, biophysical, structural and cell biological analyses to elucidate mechanisms, and also study how these mechanisms change with evolution. A major focus of the lab is to understand the allosteric communication that enables proteins to be exquisitely responsive to input signals. They use high-throughput mutational analysis to determine the sensitivity of these mechanisms to perturbations, in order to determine the molecular principles governing regulation and specificity. For more information about Dr. Kuriyan and the lab’s research, please visit https://jkweb.berkeley.edu/

The chosen candidate will join a project aimed at understanding allosteric mechanisms, using deep-mutagenesis methods to study structure-function relationships in DNA replication proteins. The mutagenesis experiments will be augmented by biochemical and biophysical characterization of the properties of variant replication proteins. For more information about the project, see Subramanian et al., 2021 eLife (https://elifesciences.org/articles/66181).

Qualifications

Education
A Ph.D. in biochemistry, biophysics, structural biology, cell biology, or a closely related field is required.

Experience
Experience in using DNA sequencing-based high-throughput assays is required.
Experience in analyzing datasets is required.
Experience in analytical biochemistry is preferred.
Experience with protein structure and the dissection of structural mechanisms would be a plus.


[Post Date: August 17, 2021]


Postdoctoral Scholar Positions for Infectious Disease Research

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Description:

Postdoctoral scholar with competitive salaries and benefits are available immediately in the Prof. Pegan Lab at the University of California, Riverside. The individual filling this new position will assist in my federally funded related projects that seek to develop new vaccines and therapeutics for viruses that cause Crimean Congo Hemorrhagic Fever, COVID19, and others. Our primary focus is to understand the molecular mechanisms these viruses utilize to circumvent host immunity and translate that knowledge for therapeutic benefit. For additional information about our research and recent publications, please visit our website: https://profiles.ucr.edu/app/home/profile/scottp 


Molecular biology, mammalian protein expression, protein purification, structural biology (X-ray), biochemical characterizations as well as other drug discovery and biophysical techniques are the main research approaches for these studies. For postdoctoral positions, candidates should have a doctoral degree in molecular biology, biochemistry or related field, and strong background in cell culture, biochemical and molecular biology techniques.  We welcome and strongly support scientists with diverse backgrounds who are energetic and highly motivated for career advancement. Postdoctoral salary meets or exceeds NIH NRSA standards and is commensurate upon qualifications and experience 
(https://graduate.ucr.edu/postdoctoral-studies).   


A member of the world’s most prestigious public university system, UC Riverside is an institution powered by an entrepreneurial spirit, a record of innovation and results, and a commitment to excellence and collaboration across disciplines.  UC Riverside has a vibrant research environment (including 2 Nobel Laureates and more than a dozen of National Academies members).  Our lab is housed in the state-of-the-art School of Medicine Research Building, one of UC Riverside’s new modern research building.  The campus is also located in a prime position close to other universities, research institutes, and biotech industries present in Southern California. 


Riverside is a wonderful place to live, providing ample cultural and entertainment opportunities in a safe and comfortable community with affordable housing and living expenses.  Riverside is about an hour away from beautiful beaches and ski slopes. The city offers all the cultural advantages of any U.S. city, together with the amazing all-year-round weather of sunny Southern California.  
Preference will be given to candidates with research experience in utilizing the above described research techniques as well as having at least one first author publication. Preference is also given to those with one or more 1st author publication and a strong desire to perform infectious disease research. Ability to work both independently and cooperatively within a team is essential.  Applicants should send a CV, a brief research statement, and the names/contact information of three references to Prof. Scott Pegan via email: scottp@medsch.ucr.edu 

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[Post Date: August 17, 2021]


Postdoc Michigan State University

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Description:

Position Summary 

The Department of Microbiology and Molecular Genetics is seeking a post-doctoral Research Associate. The position involves enzyme biochemical characterizations and structure analyses in the laboratory of Dr. Robert Hausinger working in collaboration with Dr. Jian Hu. 

This position is available immediately for a highly self-motivated Research Associate with experience in molecular biology, protein biochemistry, and structure biology.  The position is associated with an NIH-funded project to characterize enzymes that synthesize and use the recently discovered nickel-pincer nucleotide cofactor. 

We seek an excellent scientist with hands-on training in molecular biology, protein expression/purification, and, ideally, structure determination by x-ray crystallography. 

This is a full-time, 12-month fixed-term position with reappointment contingent on satisfactory performance and available funding. 

Equal Employment Opportunity Statement 

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, disability or protected veteran status. 

Minimum Requirements 

Applicants should have a Ph.D. in biochemistry, biophysics, molecular biology or other field closely related to protein structure and enzyme characterization. 

Desired Qualifications 

The successful applicant will have demonstrated skills in molecular biology and protein purification. Experience in structure characterization is highly preferred. 

Required Application Materials 

Interested applicants should search for posting #722092 at careers.msu.edu to submit a statement describing relevant skills, research accomplishments, research interests, a current CV, and contact information for three references. 

Review of Applications Begins On 

08/25/2021 

MSU Statement 

Michigan State University has been advancing the common good with uncommon will for more than 160 years. One of the top research universities in the world, MSU pushes the boundaries of discovery and forges enduring partnerships to solve the most pressing global challenges while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges. 


[Post Date: August 12, 2021]


Associate Director of the Laboratory of Biomolecular Structure and Function

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Description:

The Laboratory of Biomolecular Structure and Function (LBSF) at the University of Oklahoma Health Sciences Center (OUHSC) seeks an experienced crystallographer to run the daily operations of the LBSF. The position is at the Assistant Professor of Research level. The candidate will be responsible for working with PIs to advance their structural biology projects. These efforts will include routine technical operations, developing new protocols to overcome challenging problems, and training the staff of user labs in protein purification, crystallization, data collection, and structure determination. The ideal candidate for this position will have a PhD and ten years of experience in macromolecular crystallography. The candidate will not be expected to write grant applications. Pluses in a candidate's background include experience with membrane protein purification and LCP crystallization,  experience with Cyro-EM, or experience with other structural biology methods.

The LBSF is part of a suite of core labs supported in part by the OUHSC Vice President of Research. The LBSF is also part of the Biomolecular Structure Core (BSC) for the Oklahoma Center of Biomedical Research Excellence in Structural Biology (OCSB), which is based on the main campus in Norman.  The BSC has contributed to the awarding of 23 million dollars in grant funding and 33 publications in the past nine years. The OCSB has been the focal point of Oklahoma's structural biology community for nine years. The community includes 50 labs at three major research institutions.

The BSC will be a vital part of a new Center for Therapeutic Science. The center will coordinate and foster the drug development pipeline with the BSC playing a central role in structure-based drug design. Most of the 12 major users of the LBSF have cancer-related projects. One project led to the 2021 publication of crystal structures of RET Kinase bound to two drug molecules recently approved by the FDA for the treatment of non-small cell lung cancer. Most of the major users are members of the Stephenson Cancer Center, a National Cancer Institute-designated cancer center.

The compensation level for this full-time position includes a generous benefits package. The position is based in Oklahoma City -- an affordable place to raise a family. To apply, please submit a cover letter, CV and contact information (name and email) for three references to Blaine Mooers, Director of the Laboratory of Biomolecular Structure and Function at OUHSC, at blaine-mooers at ouhsc.edu. The position will remain open until filled. Application review will begin immediately.

OUHSC is an equal opportunity employer and is committed to creating a diverse and inclusive environment for all employees.


[Post Date: August 11, 2021]


Postdoctoral Position in Structural Biology

View the Job Posting Here

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Description:

Cambridge, MA-based H3 Biomedicine (H3B) is a leading company in cancer genomics driven drug discovery, delivering on the promise of precision medicine. The company was launched in 2011 with an unprecedented $200 million in initial funding from Eisai, plus a continued ongoing commitment to fund H3B’s robust discovery pipeline and clinical programs. Now with three clinical stage anti-cancer molecules in active development, H3B is able to uniquely leverage distinct insights from cancer genomics and real-life patient data to advance its projects to clinical proof of concept and beyond. H3B embraces a novel business model in which it collaborates with Eisai, a leading global pharmaceutical company, to create a prolific drug discovery engine and partnership platform.

We have an exciting opportunity to join a fantastic team of scientists as a postdoc in structural biology.  H3 Biomedicine is at the forefront of cancer genomics and drug discovery.  Structural biology plays a prominent role in underpinning our mechanistic understanding of disease biology and empowering our drug design.

Principal Duties and Responsibilities

  • Function as an outstanding protein chemist with a PhD in structural biology with an emphasis in cryo-EM or x-ray crystallography.
  • Assist with a range of projects in our oncology portfolio from early to late stage with numerous opportunities for publication.
    • These projects include elucidating the structures of large proteins (>150 KD) and protein complexes that will provide new insights into cancer biology.
    • To enable these projects, H3 has invested in a GPU workstation for in house data processing / reconstruction and has entered into relationships with both U Mass and Nanoimaging for data collection.
  • The successful candidate will also be encouraged to collaborate and consult with academic advisors as needed.
  • We desire an individual with attention to detail, motivation, independence, and ambition to further our mission to improve patient lives.

Qualifications

  • Construct design
  • Expression systems (E coli, insect cells, and mammalian)
  • Experienced AKTA user
  • Western Blots
  • Cross-linking techniques
  • Sample prep for Negative stain and Cryo-EM techniques
  • Data processing (particle picking, 2-D classification, 3-D reconstruction, Model Building, Refinement)
  • Software CCP4, CCP-EM, RELION, cisTEM, Coot, Pymol
  • Excellent written and verbal communication
  • Nice to have: crystallization techniques (basics screening, optimization, seeding, soaking, harvesting, freezing)


[Post Date: August 9, 2021]


Postdoctoral Fellow, Structural Biology and Biophysics

View the Job Posting Here

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Description:

We are seeking an enthusiastic and driven postdoctoral fellow to join the Structural and Molecular Sciences (SMS) Department at the Pfizer campus in Groton, Connecticut. This fellowship offers the unique opportunity to learn about the drug and vaccine development process in the laboratories of an innovative industry leader. The successful candidate will receive state-of-the-art training in protein structural biology and biochemistry with access to unparalleled resources supporting prokaryotic and eukaryotic protein expression, purification, and structure determination by both X-ray crystallography and cryo-EM. At SMS, we have regular access to all the major synchrotron beam lines in the world and dedicated in-house cryo-EM facilities. Ideal candidates will have extensive experience in molecular biology, protein expression, protein purification, and structure determination.


[Post Date: August 3, 2021]


Scientist in Protein Crystallography at ZoBio in Leiden (NL)

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Description:

ZoBio (www.zobio.com) was founded in 2004 and is located in Leiden, Netherlands. We offer innovative research services in the field of small-molecule drug discovery to the pharmaceutical and biotech industries. Our international team of 33 people covers four fields of expertise: Protein Engineering and Production, Assay Development and Screening, Structural Biology and Medicinal Chemistry.

We are currently looking to strengthen our team with an X-ray crystallographer with a track record in protein crystallography and a strong background in X-ray crystallographic data analysis. Experience in building and refinement of protein-small-molecule complexes would be extremely helpful.

You will support our clients’ drug discovery programs by solving ligand-protein structures. You will work with minimal supervision but in a highly collaborative environment within the Structural Biology team and will effectively cooperate on a per-project basis with other research groups at ZoBio. Your role will require working simultaneously on multiple projects in a rapidly evolving environment. Team spirit and excellent organization and communication skills are essential.

TASKS & RESPONSIBILITIES

  • High-throughput crystallographic screening utilizing automation and robotics
  • High-throughput and -quality structure elucidation and interpretation of biological macromolecules in complexes with small molecules of interest
  • Utilization of X-ray crystallography pipelines with the aid of computational structural biology tools to aid the efficient structure elucidation of protein-ligand complexes
  • Prepare presentations on the structural data for project teams and clients
  • Maintain up-to-date understanding of the current state of the field in X-ray crystallography in relation to modern drug discovery challenges

REQUIREMENTS

  • PhD in relevant field with experience in an industrial or collaborative setting
  • Hands-on experience with ligand modelling into electron density maps and macromolecular model building and refinement in the context of Structure-Based Drug Discovery campaigns
  • Hands-on experience in solving challenging X-ray crystallography cases (e.g.ab initio structure solution)
  • Experience with computational structural biology tools such as ligand docking, virtual screening, and molecular dynamics simulation would be considered an advantage
  • Experience in scripting and programming would be considered an advantage
  • Ability to work in a team in a result-driven, goal-oriented environment

It is fully expected that you will become a permanent and integral member of the ZoBio team after an initial period of 12 months. Applicants at either the Senior Scientist or Scientist level will be considered.

A tailored remuneration package will be proposed in line with individual qualifications and experience. The position is immediately available; the evaluation and assessment of candidates will run until the position is filled.

Please send your CV, motivation letter and names of potential referees at <hrm@zobio.com> with the subject: “Scientist in Protein Crystallography”.


[Post Date: August 3, 2021]


Postdoc Biosynthesis, Secretion, & Function of Extracellular Polysaccharide

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Description:

Several postdoctoral positions are available immediately for highly motivated individuals with a strong interest in structural and functional analyses of polysaccharide secretion systems. 

The Zimmer lab integrates structural biology with glycobiology and biophysics to delineate how cell surface polysaccharides are synthesized, transported to the cell surface, and assembled to perform diverse biological functions. Postdoctoral positions are available to study the biosynthesis of biofilm polysaccharides, ABC transporter-mediated complex carbohydrate secretion, as well as plant cell wall assembly. The projects combine structural biology and biochemistry with polymer physics to correlate how enzymatic functions influence material properties.   

The incumbents will benefit from a diverse and highly collaborative research environment at the University of Virginia School of Medicine, state of the art cryo electron microscopy and macromolecular crystallography facilities, as well as an outstanding infrastructure for biophysical characterizations of membrane transport processes. Excellent molecular biology skills are essential and experience in structural biology techniques is advantageous. Interested individuals should send a brief cover letter, a curriculum vitae, and contact information for three references to Jochen Zimmer (jz3x@virginia.edu). 

The University of Virginia is located in Charlottesville, just 2 hours from Washington DC and 90 min from Richmond. Charlottesville is a vibrant and international town that offers an exceptional quality of life with ample outdoor activities within the city and nearby Shenandoah National Park. 


[Post Date: August 3, 2021]


Postdoc University of Texas McGovern Medical School

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Description:

A NIH-funded postdoctoral position is available immediately in the Department of Biochemistry and Molecular Biology at University of Texas McGovern Medical School in the laboratory of Dr. Lei Zheng to study the structure of a membrane phosphatase protein and its novel regulatory mechanism. The project involves X-ray crystallography, single-particle cryo-electron microscopy, and fluorescence spectroscopy. 

The ideal candidate should have a recent Ph.D. in Structural Biology, Biochemistry or Microbiology with demonstrated experience in protein expression, purification and characterization. Experience with membrane protein will be a great asset. 

The laboratory is located in Texas Medical Center, the largest campus for medical research in the world, which provides outstanding environments and opportunities for academic development.  Houston is a highly culture-diversified city with affordable living costs. Salary will be based on NIH standard and individual experience.

Interested applicants should send their CV and the names of three references to Dr. Lei Zheng (lei.zheng@uth.tmc,edu).


[Post Date: July 28, 2021]


Postdoctoral Position in Structural Biology and Epigenetics at UC Riverside

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Description:

Position Description: A post-doctoral position is immediately available for highly motivated, hard-working candidates to join Dr. Jikui Song’s group in the Department of Biochemistry at University of California, Riverside. Dr. Song’s research group employs collaborative and multidisciplinary approaches to investigate mechanistic basis of cancer epigenetics, in particular chromatin modifications that are essential for gene regulation and cell development. We are also exploring the mechanistic basis and regulatory mechanisms of viral replication, toward identification of effective therapeutical strategies against viral infection. The project will involve structural and dynamic characterization of macromolecular complexes using cryo-EM, X-ray crystallography, single-molecule FRET and other biochemical/biophysical approaches. Examples for recent publications include Zhang et al. Nature (2018) 554:387-391, Wang et al. Nat. Struct. Mol. Biol. (2020) 27: 875-885, Gao et al. Nat. Commun. (2020) 11:3355, and Ren et al. Nat. Commun. (2021) 12:2490.

Research Environment: The NIH-funded research in the Song lab aims to uncover the fundamental principles underlying epigenetic regulation and pathogen-host interaction. The successful candidates will have extensive opportunities for multiple collaborations with scientists at UC Riverside and worldwide. UC Riverside is located at the metropolitan area of Los Angeles. Such an environment allows one to have a good balance of life and science.

Qualification and Experience: Successful candidates will have a recent PhD in structural biology, biophysics or other related fields, with extensive experience in protein production, biochemical characterization and structural analysis. Additional background in cryo-EM and/or enzymatic assay is considered a plus but not essential. Applications will be reviewed as they are received. The position will remain open until filled. Postdoctoral salary will be commensurate with prior research experience and qualifications.

Application: Interested applicants should send curriculum vitae, expected starting date, brief summary of previous research experience, and contact information of 2-3 references as one single PDF file to Jikui Song, Ph.D. Department of Biochemistry, University of California, Riverside, CA 92521 (Email: jikui.song@ucr.edu).

More information can be found in https://songlab.ucr.edu.


[Post Date: July 19, 2021]


Postdoc Structural and Functional Characterization of Macromolecular Complexes in Transcription and Repair

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Description:

A postdoc position, supported by NIH funding, is available in the Dong Wang Lab at University of California, San Diego.

Our research focuses on the interplay between two fundamental processes: transcription and DNA repair. Current research projects focus on the X-ray and CryoEM structural elucidation and functional/biochemical study of macromolecular protein-nucleic acid complexes involved in transcription, chromatin remodeling, and DNA repair. Please visit https://dongwang.ucsd.edu for details of our recent research and publications.

We are looking for a highly motivated individual with experiences in biochemistry, and molecular biology, X-ray crystallography, or CryoEM. We sincerely invite you join our small, but vibrant and highly productive team. Candidates must have at least one original first author publication in the related field in an internationally recognized journal. Please send your CV, list of publications, and the names and Email addresses of 2-3 references to dongwang@ucsd.edu before Oct 15, 2021.


[Post Date: May 13, 2021]