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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Postdoc Time-Resolved Serial Synchrotron Crystallography at ESRF ID29

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Description:

Context & Job description

As part of the Extremely Brilliant Source facility upgrade (https://www.esrf.eu/about/upgrade), the ESRF is constructing a new beamline for serial and time-resolved macromolecular crystallography (TR-)SSX experiments at room temperature. The new ID29 beamline will deliver an unprecedented flux density, allowing the recording of diffraction data from micron-sized samples in a few microseconds, and will be equipped with a next generation diffractometer and a Jungfrau detector. Beamline operations will be supported by a dedicated sample preparation laboratory where the most suitable crystal delivery systems such as injectors, fixed targets and microfluidic devices will be prepared and characterised prior to experiments.

The postdoctoral position available will focus on developing novel sample environments, delivery systems and data collection methods for (TR-SSX). These will, initially, be tested and commissioned at other ESRF MX microfocus beamlines. The selected candidate will also take part in the commissioning of the new ID29, performing state-of-the art experiments at the new end-station.

As for all post-doctoral researchers in the Structural Biology Group, the successful candidate will participate in in-house research programmes, will contribute to the operation of the beamline and will provide support to external users as local contact. He/She will also have the opportunity to develop his/her own research programme.

Expected profile

  • PhD in chemistry, physics, biophysics, biology or closely related science obtained less than 3 years ago
  • A strong background in X-ray crystallography and serial crystallography is desirable
  • A strong interest in new method development
  • Ability to interact with multi-disciplinary staff and facility users
  • Proficiency in English (working language at the ESRF)

Working conditions

Contract of 18 months, renewable for a further 6 to 18-month period.

We offer a comprehensive benefits package designed to support your quality of life and your installation in the Grenoble area when relocation is needed.

The annual gross salary may be completed by additional allowances (shift allowance, standby allowance, expatriation allowance, etc.).


[Post Date: April 22, 2021]


Structural Biology and Biophysics Research Scientist

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Description:

Job Description

We are currently seeking a self-motivated scientist with experience in the field of Protein Production, Structural Biology and Biophysics. The successful candidate will be joining a team of biophysicists and structural biologists focused on delivery of transformative medicines for a range of serious genetic diseases and conditions with an unmet medical need. You will be working closely with teams across Vertex in our early stage portfolio.  This position provides the candidate with a world-leading opportunity to learn and develop skills in drug discovery in a patient-focused environment.

The successful candidate will be able to demonstrate relevant academic or industrial experience with challenging targets such as protein complexes and/or membrane proteins. An ability to critically assess the scientific literature, design and run your own experiments is a key feature for this role. An innovative and “can-do” attitude is essential for working in our high throughput and high impact team.

You will have strong hands-on experience in mammalian protein expression in mammalian or Baculovirus expression systems and purification of challenging targets. Practical expertise in solving and interpreting structures of macromolecules using techniques such as cryo-EM and X-ray crystallography with particular application to membrane proteins and/or large protein complexes will be an essential component of this role. Hands-on experience in a broad range of biophysical or biochemical techniques, preferably using high throughput methods, would also be an advantage.   

You will be part of a growing, high impact team exploring and implementing new ideas in protein production, structural biology and biophysics to increase efficiencies and drive innovation. You will be working collaboratively with multiple interdisciplinary teams both on site here in the U.K. and globally, to understand and fulfil the demands of the specific projects by establishing efficient work plans and developing new protocols.

The successful candidate will have an exciting opportunity to contribute to high impact and strategic science across our early research portfolio. As a key player within multi-disciplinary drug discovery teams, you will be exposed to every aspect of drug discovery and development in one of the world's leading biotechnology companies with an uncompromising commitment to patients.

Key responsibilities

  • Maintaining an in depth understanding of the biochemistry, molecular structure and wider role of each target in disease through critical analysis of the literature, working closely with our disease biology teams.
  • Purification of proteins and other macromolecules for structural, biophysics and high throughput assays
  • Determination of structure of macromolecules by X-ray crystallography, cryo-EM and/or cryo-ET.
  • Biophysical and biochemical studies of macromolecules using a range of methods for target engagement and small molecule modulator development.

Key requirements

  • Ph.D. level Biochemist or Biologist with extensive proven laboratory experience from similar roles in the pharmaceutical industry setting and/or in academia.
  • A track record in delivering high impact results in biophysics, structural biology and protein science within academic or pharmaceutical industry settings as demonstrated through a strong publication history, supported by evidence of individual contributions to projects.
  • Practical experience of recombinant protein expression in several mature platforms including mammalian (stable and transients), insect cells and E.coli. Strong practical experience in protein purification including IMAC, IEC, SEC, IEX, HIC, fusion protein cleavage technologies, use of AKTA system-based chromatography.
  • Practical experience in structural biology, using X-ray crystallography and/or electron cryo-microscopy with a focus on membrane proteins and/or protein complexes.
  • Experience in the use of a range of biophysical methods, particularly in the context of assessing small molecule target engagement.
  • Familiarity with high-throughput methods for assessing protein expression and purification yields and quality.
  • Strong understanding of molecular biology, protein engineering, mass spectrometry, assay development, electrophysiology and/or high-throughput screening workflows would be an advantage.
  • Strong interpersonal and troubleshooting skills.
  • Demonstrate excellent record keeping, communication and presentation skills.
  • Demonstrable leadership for promoting innovation in those techniques and demonstrable abilities to troubleshoot problems as they arise.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.


[Post Date: April 22, 2021]


Biochemist/Assay Development Scientist at FoRx Therapeutics

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Description:

FoRx Therapeutics is a privately held drug discovery company based in Basel, Switzerland. The company focuses on drugging key molecular targets involved in DNA Replication Stress, which constitutes an exciting and innovative approach in the development of novel anticancer drugs. FoRx is backed by a syndicate of investors that include the Novartis Venture Fund, Pfizer Ventures, M Ventures, Omega Funds and LSP Venture Capital. 

We are looking for a highly motivated and skilled Biochemist / Assay Development Scientist to join our growing team. This is an exciting opportunity to become an integral part of an innovative and dynamic start-up company. 

Key responsibilities of this role include, but are not limited to:

  • Expression and purification of recombinant proteins
  • Develop and perform a diverse set of biochemical assays, in particular enzymatic (e.g. enzyme activity and kinetics) and substrate binding assays
  • Design biophysics-grade protein constructs and pilot / contribute to the optimization of purification protocols
  • Screen small molecule ligands on purified protein in microplate-based assay formats to drive the understanding of SAR relationships using manual and automated systems
  • Crystallize or work in close collaboration with crystallographers to crystallize protein-ligand complexes in support of structure-aided drug development
  • Organize experimental results to be shared with project teams; maintain clear experimental records using ELN (electronic lab notebook)

Qualifications:

  • Recent PhD degree in Biochemistry or similar (e.g. Structural Biology)
  • 1-2 years of relevant experience in industry would be a strong plus
  • Profound experience and hands-on expertise in biochemical assays, enzyme kinetics and substrate binding assays
  • Experience in recombinant protein production using different expression systems, including construct design and optimization
  • Experience in using biophysical assays (SPR, ITC, DSF, etc.) for probing protein-ligand interactions
  • Expertise in X-ray protein crystallography would be an asset
  • First author publication in a relevant journal is required
  • Flexible, proactive, efficient, and able to work independently with a problem-solving attitude
  • Strong team player, high-energy and positive personality
  • Fluent in written and spoken English

The successful candidate will be an enthusiastic, self-driven individual who is flexible and responsive to the changing needs of a dynamic entrepreneurial organization, has the ability to communicate effectively, is an excellent fit to an agile and growing biotech team, and has the ambition to perform outstandingly.

FoRx Therapeutics encourages and supports a diverse work environment as an Equal Opportunity Employer, offering a stimulating work environment and a competitive compensation package.

Interested candidates should send a cover letter describing research interests and career goals, along with a Curriculum Vita to 

hr@forxtherapeutics.com

We thank all applicants for their interest, however only those candidates selected for interviews will be contacted. 


[Post Date: April 22, 2021]


Scientist I – Structural Biology ( X-ray crystallography)

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Description:

Job ID: req1845
Employee Type: exempt full-time
Facility: ATRF: Other
Location: 8560 Progress Drive, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public’s interest.  

 Position Overview:

PROGRAM DESCRIPTION

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

KEY ROLES/RESPONSIBILITIES

Scientist I – Structural Biology

  • The candidate will join the structural biology group within the RAS initiative and will be responsible for the crystallization and the structure determination of protein-small molecule and protein-protein complexes by X-ray crystallography
  • The work will include construct design, biochemical and biophysical characterization, crystallization, X-ray data collection, structure determination, and analysis
  • The candidate will work closely with protein scientists, biophysicists, and protein NMR scientists as part of an integrated structural biology effort
  • The candidate will be a member of the drug discovery team, working closely with computational and medicinal chemists on structure-based drug design approaches for small molecule agent optimization. The candidate will be expected to be able to participate in experimental design and to conduct experiments in a priority-driven environment independently
  • The candidate will be responsible for completing projects independently and as part of a team and will be responsible for timely updates of the project progress to their supervisor both informally and by formal report writing
  • Work requires the use of personal protective equipment and adherence to strict safety protocols

BASIC QUALIFICATIONS

  • Possession of a PhD degree in structural biology, protein biochemistry/biophysics, crystallography, or in a related discipline from an accredited college or university, according to the Council for Higher Education Accreditation
  • Proven ability in all aspects of protein crystallography from construct design through structure determination and analysis
  • Experience in the crystallization of protein-small molecule and protein-protein complexes
  • Expertise in commonly used structural biology software packages
  • Proficiency in protein biochemical and biophysical assays
  • Excellent communication and witting skills
  • Detail-oriented, highly organized and able to manage multiple tasks and deliver quality data
  • Must be able to obtain and maintain a clearance

PREFERRED QUALIFICATIONS

  • Experience in analyzing protein small-molecule interaction using isothermal titration calorimetry (ITC), differential scanning fluorimetry (DSF), and NMR techniques
  • Knowledge of mechanistic enzymology, and protein chemistry

JOB HAZARDS

  • This position is subject to working with radioactive material and requires to become an approved radiation worker

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)


[Post Date: April 21, 2021]


Team Leader (Structural Chemical Biology, Dundee—Almirall PROTAC collaboration)

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Description:

we are recruiting a Team Leader to lead a new team of five scientists as part of a drug discovery collaboration between my group at the School of Life Sciences at the University of Dundee, and Almirall (a global pharmaceutical company focused on skin diseases with high level of unmet medical need) and its Research Department located in Barcelona, Spain. The successful candidate and the team will be based in the new Dundee Centre for Targeted Protein Degradation.

https://www.dundee.ac.uk/stories/new-protein-degradation-centre-lead-drug-discovery-revolution 

We are looking for candidates with outstanding academic or industrial track record along with demonstrated ability to lead projects and teams. Relevant experience in structural biology and biophysical assays to study protein-ligand and protein-protein interactions.  Experience with PROTAC / targeted protein degradation drug discovery would be an advantage but is not essential. 

The post is available immediately and for a period of 3 years. Salary will depend on experience, but will be up to £49,553. This is a unique opportunity to gain experience in industry-style drug discovery within an academic setting.


[Post Date: April 20, 2021]


Structural Biology Postdoc Ohio State University

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Description:

Applications are invited for a joint postdoctoral position in the laboratories of Dr. Sarah Heissler and Dr. Krishna Chinthalapudi at the Ohio State University. The research project focuses on understanding the role of myosin motors and other cytoskeletal proteins in health and disease. We combine biochemical, biophysical and cell biological methods with high resolution imaging and state-of-the-art structural biology approaches including X-ray crystallography and cryo-EM to investigate how protein structure is related to its function.

Candidates must have a Ph.D. degree and strong practical experience in biochemistry and structural biology. Experiences with cell biology and high-resolution imaging are desirable.

To be considered for this position, please email your curriculum vitae, a short cover letter with research experience and interests and contact information for 3 references to Sarah Heissler (sarah.heissler@osumc.edu) and Krishna Chinthalapudi (krishna.chinthalapudi@osumc.edu).


[Post Date: April 20, 2021]


MX Industrial Service Scientist at Swiss Light Source, PSI

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Description:

We are looking for an Industrial Service Scientist to join the macromolecular crystallography (MX) team at the Swiss Light Source.

Your new role

You share knowledge to help industrial customers make the most of our beamlines and crystallization facilities. You prepare samples for structural analysis, collect X-ray diffraction data, and handle data from processing to interpretation. Collaborating with facility staff, you contribute to ongoing projects, such as Fast Fragment and Compound Screening, and new automated solutions for MX beamlines. At conferences and workshops, you promote our MX industry services.

This job is for you if

  • You are enthusiastic about supporting our Macromolecular Crystallography Group with your PhD knowledge and know-how in X-ray crystallography and structural biology.
  • You have handled X-ray diffraction data collection at a Synchrotron facility in a past role.
  • You love creating and handling service initiatives in an interdisciplinary environment.
  • You feel comfortable presenting, explaining, and discussing MX services in English.

About Us

Join the largest research institute for natural and engineering sciences in Switzerland! At the Paul Scherrer Institute, people come together from across the globe to collaborate on ground-breaking research in different fields. Our mission: to find sustainable solutions to fundamental questions facing society, science, and the economy.

Company culture

People from multicultural backgrounds and as many as 60 nations work together at the PSI, enriching the local culture with a cosmopolitan way of life. One in four of our 2,100 staff are completing their vocational training, post-doctoral, or post-graduate studies. To foster professional and personal growth for all, we have created a diverse research environment that promotes inclusion and equal opportunities at all levels. These values inform our hiring process.

This is a 3-year project position with job sharing possibility. The closing date is 15th May 2021.

For further details, please contact Katherine McAuley (katherine.mcauley@psi.ch) or for more information.


[Post Date: April 19, 2021]


Head of the Biochemistry and Structural Biology Unit of the European Institute of Oncology of Milan, Italy

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Description:

The European Institute of Oncology IEO of Milan (Italy) invites applications for a Head of the Biochemistry and Structural Biology Unit (BSU).
The BSU is located within the Department of Experimental Oncology (https://www.research.ieo.it/research-and-technology/technological-units) where it mainly provides direct support to the IEO researchers in the area of protein production, biophysical characterization, and structure determination. The BSU works mainly in the context of collaborative projects with the IEO research groups.

The Head of the BSU will play an essential role in the design and implementation of protein expressions protocols, purification strategies, biophysical and structural characterization. This will involve the establishment of strategies for optimal protein production and macromolecular complex reconstitution; the maintenance of updated protocols for biophysical characterization and crystallization; the determination of 3D structures by X-ray crystallography; and the development of pipelines for structure determination by cryo-EM single particle analysis.The Head of the BSU will supervise the activities of two senior research assistants and coordinate the interactions with IEO researchers. The Unit is equipped with state-of-the art instruments for sample preparation including incubators for expression in insect and mammalian cells, ÄKTA and Bio-Rad FPLC systems, Static-Light-Scattering, ITC calorimeters, Differential Scanning Fluorimetry system, and for structure determination by X-ray crystallography and cryo-EM (Mosquito crystallization robot, Crystal Imager, Vitrobot). For data collection, IEO has routinely access to synchrotron beamlines (ESRF, SLS and Diamond) via Italian BAGs, and is part of the Italian cryo-EM BAG at ESRF.

Responsibilities and duties

  • Manage daily aspects of the Unit, interactions and collaborations with the IEO researchers to design project specific workflows addressing scientists' needs in collaboration with the Unit Staff
  • Coordinate X-ray and cryo-EM data collection and processing up to 3D reconstructions
  • Train and supervise IEO scientists that need to access the BSU technological infrastructures
  • Actively participate in technological resource planning and maintenance of the Unit’s equipment
  • Interact with the manufacturers and service engineers of various equipment in coordination with the maintenance workshop of the department
  • Actively participate in meetings and conferences to present the data generated by the BSU

Qualifications

  • Degree and Ph.D. in a relevant scientific discipline
  • Strong commitment in fundamental and translational mechanistic research
  • Proven experience in structural biology, with specific expertise in protein production and biochemistry
  • Ability to work independently in an intellectually challenging, rapidly-paced multidisciplinary environment
  • Ability to work and communicate in English

A competitive salary will be offered on the basis of the candidate experience and career stage. The European Institute of Oncology is an equal opportunity employer that celebrates diversity and is committed to creating an inclusive environment for all employees.


[Post Date: April 19, 2021]


Industry position in Leadxpro AG - GPCR X-ray crystallographer

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Description:

Based in Villigen, Switzerland, leadXpro AG is a lead compound discovery company focusing on membrane protein drug targets such as GPCRs, ion-channels and transporters. Based on a unique platform for membrane protein expression, purification and engineering, and with preferred access to synchrotron/free electron laser (SLS/SwissFEL) for X-ray analysis and cryo-EM facilities (Uni Basel), leadXpro is able to characterize the interaction of small molecules and biotherapeutics with drug targets timely to impact the drug discovery of novel therapeutics.

To further expand our team, we are opening a position for a X-ray crystallographer, with a primary focus on GPCR. The successful candidate will be expected to work within a dynamic team that values transparency, integrity, reliability and a passion for science to create benefits for patients.

Key duties include:

  • GPCR construct design to enhance expression, stability and crystallisability
  • Purification of GPCR using standard chromatography methods
  • Constructs screening, monitoring of protein quality and purity using fluorescence-size exclusion chromatography
  • Crystallisation of GPCR in lipidic cubic phase, vapour diffusion or bicelle crystallisation
  • Data collection at synchrotron, data processing and structural refinement of GPCR/ligand complexes
  • Work in collaboration with a multi-discipline team and external collaborators
  • Actively develop the scientific reputation and methodology of GPCR crystallisation of the company

The successful candidate should have

  • A Ph.D. in biochemistry, molecular biology, biotechnology or a related discipline
  • At least 5 years of postdoctoral experience in an academic or industrial setting
  • Demonstrated expertise and success track record in GPCR/membrane protein structural biology
  • Excellent track record of crystallisation and structural solution of GPCR/ligand complexes
  • In-depth knowledge of synchrotron data collection and X-ray crystallography data processing software packages including CCP4, XDS and PHENIX
  • Excellent interpersonal communication skills and fluency in English
  • Proven ability to work in a collaborative environment
  • Experience in an industrial environment will be an advantage

For further detail, please check with our website (www.leadxpro.com) or linkedin (https://www.linkedin.com/company/leadxpro-ag/)

Deadline for application is 15th May.


[Post Date: April 19, 2021]


Postdoc Structural Cell Biology

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Description:

The Hoelz laboratory at the California Institute of Technology seeks to recruit two outstanding postdoctoral scientists in structural cell biology. Our laboratory focuses on the structure-function relationships of the nuclear pore complex and associated nucleocytoplasmic transport machinery.

This position requires a recent Ph.D. degree in biochemistry/biophysics with a strong background in biochemistry, x-ray crystallography, and/or cryo-electron microscopy/tomography. The successful applicant should be a highly motivated individual with good organizational, communication, and interpersonal skills, who is able to carry out a structure determination project from the development of recombinant protein expression systems to structure refinement.

The laboratory is well-funded and equipped with modern biophysical instrumentation. Importantly, Caltech has an exceptional infrastructure for structural biology, including access to a high intensity, completely automated, state-of-the-art crystallography beamline at the Stanford Synchrotron Radiation Lightsource (SSRL), as well as an excellent cryo-electron microscopy facility with access to FEI Arctica and Titan Krios microscopes equipped with Gatan K3 cameras. 

The positions are available immediately and funded for 3+ years. Depending on performance, the position can be extended for additional years.

To apply, please send your CV, a statement of research interests, and the names and contact information of at least two references to André Hoelz (hoelz@caltech.edu).

http://ahweb.caltech.edu/AH_Web/Hoelz_Lab_Home.html


[Post Date: April 19, 2021]


Scientist/Senior Scientist, Structural Biology

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Description:

Location: Cambridge, Massachusetts, United States
Full-time

Constellation’s Drug Discovery team is growing, and we are looking for a crystallographer to contribute to the structural characterization of drug targets. This role will focus on recombinant protein construct design, wet-lab protein crystallization and crystallography, and will also require smooth and collegial management of CRO relationships.

In this role you will: 

  • Collaborate with colleagues in Lead Discovery, Biology, and Chemistry to develop structural biology and protein production strategy.
  • Design recombinant protein expression gene constructs for assays and crystallization; assisting in the optimization of purification protocols.
  • Crystallization, X-ray structure determination, and analysis of important drug targets.
  • Shared administration of Constellation’s in-house structure database
  • Provide regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with medicinal and computational chemists.
  • Participate in the management of collaborations with contract research organizations (CROs)
  • Contribute to target feasibility analyses

We are looking for people who have: 

  • PhD with 0-3 years experience or Master’s degree with 5-10 years experience in Structural Biology, Biophysics, Biochemistry or a closely related field
  • Demonstrated competency in protein construct design for crystallization
  • Demonstrated competency in expression and purification strategies using bacterial, insect, yeast, and/or mammalian hosts.
  • Expertise in protein crystallization and X-ray structure determination of protein-ligand complexes.
  • Knowledge of protein structure and function, with the ability to articulately communicate structural information to a broad scientific audience
  • Excellent time management and communication skills
  • Ability to work in a goal-oriented, team-driven environment, with a collaborative and proactive attitude
  • Experience with other structural techniques (e.g. cryo-electron microscopy, small-angle X-ray scattering) and/or biophysical techniques is strongly preferred.
  • Working knowledge of computational chemistry or computer aided drug design (CADD) is desirable
  • Shell scripting (eg bash, python, awk, etc) experience is desirable


[Post Date: April 16, 2021]


Assistant Staff Scientist

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Description:

Overview

An Assistant Staff Scientist position is available to help build and manage a structural biology laboratory at UAMS and to make it available to the UAMS community. The Winthrop P. Rockefeller Cancer Institute (https://cancer.uams.edu/) has made sizable investments to strengthen structural biology at UAMS and to make it an integral part of its cancer research programs. The successful candidate will train users in the best use of newly purchased equipment, assist as needed in structure determination by X-ray crystallography and cryoEM, and help build, manage, and maintain the structural biology facility. This is an exciting opportunity to impact several diverse research projects in a team-oriented environment.

 

The University of Arkansas for Medical Sciences (UAMS) has a unique combination of education, research, and clinical programs that encourages and supports teamwork and diversity. We champion being a collaborative health care organization, focused on improving the health, health care, and well-being of Arkansans.

UAMS offers amazing benefits and perks:

  • Health: Medical, Dental and Vision plans available for staff and family
  • Holiday, Vacation and Sick Leave
  • Education discount for staff and dependents (undergraduate only)
  • Retirement: Up to 10% matched contribution from UAMS
  • Basic Life Insurance up to $50,000
  • Career Training and Educational Opportunities
  • Merchant Discounts
  • Concierge prescription delivery on the main campus when using UAMS pharmacy

Salary offered commensurate with experience

Responsibilities

  • Assist collaborating users of the facility in successful structure determination by X-ray crystallography or cryoEM.  The extent of assistance will depend on individual user involvement.
  • Provide advice on protein constructs and purification. 
  • Assistance or performance of crystallization screening or crystal optimization, harvesting and freezing crystals for collection of X-ray diffraction data, collection of diffraction data, structure solution, and refinement. 
  • Preparation and freezing of grids, evaluation of samples by negative stain and cryoEM with the TF20 microscope in the Digital Microscopy Core via coordination and scheduling with members of the Digital Microscopy Core, collection of high-resolution cryoEM data at national facilities, particle selection, classification, structure refinement, coordinate structure determination, and coordinate refinement.
  • Train students, postdoctoral fellows, and scientists in basic laboratory techniques.
  • Overseeing staff compliance with the University, State and Federal guidelines for the safe operation of a laboratory.
  • Placing orders (obtaining quotes, filling and submitting ordering forms, tracking order status and receiving orders).
  • Maintaining records of laboratory inventories (supplies).
  • Maintain laboratory equipment (Mosquito crystallization robot, Formulatrix plate hotel, FEI vitrobot, EMS gloqube).
  • Perform other duties as assigned.

Qualifications

Ph.D in Bioscience or related field required. Must have postdoctoral or equivalent experience.

 

Knowledge, Skills & Abilities:

  • 5 years of laboratory experience in X-ray crystallography and/or CryoEM (preferably both).
  • Pragmatic experience in “gene-to-structure” determination by X-ray crystallography and/or cryoEM (preferably both). 
  • Experience in bacterial protein expression and purification.

Preferred Qualifications:

  • Experience in protein expression and purification using other cell hosts (mammalian,
    yeast, insect cell).
  • Experience in assisting and guiding scientists towards structure determination by Xray crystallography and/or cryoEM.


[Post Date: April 15, 2021]


Postdoctoral Research Associate Time-Resolved Synchrotron Crystallography

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Description:

Brookhaven National Laboratory (www.bnl.gov) delivers discovery science and transformative technology to power and secure the nation’s future. Brookhaven Lab is a multidisciplinary laboratory with seven Nobel Prize-winning discoveries, 37 R&D 100 Awards, and more than 70 years of pioneering research. The Lab is primarily supported by the U.S. Department of Energy’s (DOE) Office of Science. Brookhaven Science Associates (BSA) operates and manages the Laboratory for DOE. BSA is a partnership between Battelle and The Research Foundation for the State University of New York on behalf of Stony Brook University.

Organizational Overview

Brookhaven National Laboratory is entering an exciting new chapter with one of the newest and most advanced synchrotron facilities in the world. National Synchrotron Light Source II (NSLS-II) enables the study of material properties and functions with nanoscale resolution and exquisite sensitivity by providing world-leading capabilities for X-ray imaging and high-resolution energy analysis.

This facility is open to users from academia and industry and its operations are at a time when the world enters a new era with a global economy fueled largely by scientific discoveries and technological innovations. NSLS-II provides the research tools needed to foster new discoveries and create breakthroughs in critical areas such as energy security, environment, and human health.

Position Description

The National Synchrotron Light Source-II (NSLS-II) at Brookhaven National Laboratory seeks a postdoctoral research associate to join the Structural Biology program that operates two state-of-the-art macromolecular crystallography (MX) beamlines, one life-sciences scattering beamline, and a cryo-EM facility. The successful researcher who joins our multi-national multi-disciplinary team will make best use of the Frontier Macromolecular Crystallography (FMX) beamline’s unsurpassed brightness and micro-focus beam and expand its scientific capabilities.The project will establish room temperature and time-resolved serial synchrotron crystallography at the FMX beamline, in a close collaboration with our colleagues at the BNL Biology department with the goal to study dynamic processes in proteins such as enzymatic reactions. The position is a two-year term appointment.


Essential Duties and Responsibilities:

  • Study dynamic and time resolved processes in proteins by designing a fixed-target chip-scanning goniometer for the experimental station at FMX,
  • Develop sample handling protocols and a droplet-based reaction trigger mechanism
  • Design the time-resolved serial synchrotron crystallography (SSX) experiment and associated data analysis.
  • Successful structure solutions of reaction intermediates will provide new insights into protein function and establish the method of time resolved serial synchrotron crystallography at the FMX beamline. 

Position Requirements

Required Knowledge, Skills, and Abilities:

  • Ph.D. in physics, biophysics, chemistry, biochemistry, or related field
  • Demonstrated background in Macromolecular Crystallography data acquisition and analysis.
  • Demonstrated publication record in X-ray or neutron-based research
  • Excellent oral and written communication skills and effective interaction in a team environment.

Preferred Knowledge, Skills, and Abilities:

  • Experience in the use of synchrotron beamlines for structural biology
  • Experience in protein purification and sample preparation for structural analysis
  • Interest or skills in instrument development, particularly in liquid handling
  • Experience with programming, including Python.
  • Proficiency in scientific computation and large-scale data processing


BNL policy requires that research associate appointments be made to individuals who have received their doctorate within the past five years .

 At Brookhaven National Laboratory we believe that a comprehensive employee benefits program is an important and meaningful part of the compensation employees receive. Our benefits program includes, but is not limited to:

  • Medical, Dental, and Vision Care Plans
  • Flexible Spending Account
  • Paid Time-off and Leave Programs (vacation, holidays, sick leave, paid parental leave)
  • 401(k) Plan
  • Flexible Work Arrangements
  • Tuition Assistance, Training and Professional Development Programs
  • Employee Fitness/Wellness & Recreation:  Gym/Basketball Courts, Weight Room, Fitness Classes, Indoor Pool, Tennis Courts, Sports Clubs/Activities (Basketball, Ping Pong, Softball, Tennis)

Brookhaven National Laboratory and the Energy and Photon Sciences Directorate are committed to your success. We offer a supportive work environment and the resources necessary for you to succeed.

Brookhaven National Laboratory (BNL) is an equal opportunity employer committed to ensuring that all qualified applicants receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, status as a veteran, disability or any other federal, state or local protected class.

BNL takes affirmative action in support of its policy and to advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

Brookhaven National Laboratory (BNL) is an equal opportunity employer that values inclusion and diversity at our Lab.We are committed to ensuring that all qualified applicants receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, status as a veteran, disability or any other federal, state or local protected class.

BNL takes affirmative action in support of its policy and to advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.We ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.Please contact us to request accommodation.

*VEVRAA Federal Contractor

Brookahven employees are subject to restrictions related to participation in Foreign Government Talent Recruitment Programs, as defined and detailed in United States Department of Energy Order 486.1A. You will be asked to disclose any such participation at the time of hire for review by Brookhaven. The full text of the Order may be found at: https://www.directives.doe.gov/directives-documents/400-series/0486.1-BOrder-a/@@images/file


[Post Date: April 14, 2021]


Post-Doctoral Position in Microfluidics and Macromolecular Crystallography in Grenoble

View the Job Posting Here

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Description:

We are seeking a highly motivated researcher for an 18-month post-doctoral position to develop microfluidic devices for microcrystallisation and serial X-ray crystallography experiments.

The position is part of the MicroCrys project, which will optimise the existing microchip manufacturing process, finalise the chip thermoregulation system and automate the crystallisation process via microdialysis. The post-doctoral student will also validate the equipment on test cases, with the objective to transfer the technology to the market. MicroCrys is funded by Linksium, a Société d'Accélération du Transfert de Technologies (SATT) in Grenoble Alpes which is a major player in the economic development of innovation. The selected candidate will carry out his/her research activity in the team dedicated to the MicroCrys project within the Synchrotron group (https://www.ibs.fr/research/research-groups/synchrotron-group/) at the Institut de la Biologie Structurale in Grenoble, France. The starting date should be before September 2021, preferably in June 2021.


[Post Date: April 8, 2021]


Translational Human Immunology Postdoc

View the Job Posting Here

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Description:

Application Window

Open February 17th, 2021 through Friday, Jun 18, 2021 at 11:59pm (Pacific Time)

Position description

One Postdoctoral Fellow position is immediately available in Dr. Lisa Wagar’s laboratory (wagarlab.webflow.io) in the Department of Physiology and Biophysics (http://physiology.uci.edu/) and the Institute for Immunology (http://www.immunology.uci.edu/), University of California Irvine. The mission of our laboratory is to investigate the human adaptive immune response to infectious diseases and vaccines using immune organoid technologies, with the long-term goal of improving vaccine design and preventing infectious disease. We are currently seeking a Postdoctoral Fellow to lead a study on the immunogenicity of candidate vaccine antigens and investigate what features of human immune responses predict a protective outcome. There will be opportunities to publish research articles and to also contribute to collaborative projects ongoing in the lab.

Successful candidates will have a strong background in one or more of the following research areas: human immunology, organoid technology, and/or infectious diseases and vaccine work. In addition, the candidate should have experience working with primary human samples and be capable of working both independently and in a team environment. Interest in learning about bioengineering or biomaterials, familiarity with flow cytometry, and experience working under BSL2 precautions are a plus.

Inquiries about the position should be directed to Lisa Wagar, PhD: lwagar@uci.edu.

Applicants should complete the application profile and upload the following application materials electronically to be considered for the position: https://recruit.ap.uci.edu/JPF06607

· A statement describing your experience and future research goals
· A brief statement describing your commitment to an inclusive research environment
· Curriculum vitae
· Names and contact information for 3-4 references

Applications will be considered until the position is filled. Positions are dependent on extramural funding. Rank will be determined based on qualifications and experience. Initial appointments are for one year and renewal will be dependent on availability of support. Salary commensurate with qualifications and experience

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy. A recipient of an NSF ADVANCE award for gender equity, UCI is responsive to the needs of dual career couples, supports work-life balance through an array of family-friendly policies, and is dedicated to broadening participation in higher education.

Application Requirements

Document requirements
  • Inclusive Excellence Activities Statement - Statement addressing how past and/or potential contributions to inclusive excellence will advance UCI's Commitment to Inclusive Excellence. See our guidance for writing an inclusive excellence activities statement.

  • Curriculum Vitae - Your most recently updated C.V.

  • Statement of Research - Your statement may include a research plan, brief description, and/or scholarly activities.

  • Cover Letter - Your opportunity to enhance your application packet.

    (Optional)

  • Misc / Additional (Optional)

Reference requirements
  • 3-5 required (contact information only)

Job location

Irvine, CA

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[Post Date: April 2, 2021]


Biophysics and Structural Biology Research Scientist

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Description:

We are seeking research scientists with experience in biophysics, structural biology and protein biochemistry to join our expanding team at Vertex Pharmaceuticals in Oxford.

Experience in working with challenging membrane proteins and protein complexes, using both cryo-EM and crystallography, would be advantageous for these roles.

If you have a passion for tackling difficult targets and being involved in developing therapies for patients with serious genetic diseases, please follow the link above to learn more about these positions.


[Post Date: March 30, 2021]


Laboratory Head in Lead Discovery / Biophysics

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Description:

Nuvisan ICB in Berlin is offering a permanent position as Lab Head in the field of Lead Discovery/Biophysics in Berlin, Germany.

Your main task is the development and application of biophysical assays to study protein small-molecule interactions.  You will work in interdisciplinary teams to advance drug-discovery projects.

Nuvisan INNOVATION CAMPUS BERLIN is a newly founded contract research organization with approximately 400 employees belonging to the Nuvisan group. We offer a dynamic and inspiring working environment in the heart of Berlin. ICB has a long history of experience in pharma research and the combination with Nuvisan as an international service provider for clinical studies, laboratory services and contract manufacturing offers an attractive working environment.


[Post Date: March 30, 2021]


Senior Scientist, Protein Crystallography

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Description:

ROLE SUMMARY

We are seeking a protein crystallization specialist to join the Structural Biology group at Pfizer- Boulder Research and Development Unit. This individual will work closely with our protein crystallographer to express, purify, and crystalize a variety of challenging proteins for use in both structural and mechanistic studies.

ROLE RESPONSIBILITIES

  • Design and conduct protein crystallization trials, crystal optimization, and X-ray data collection.
  • Establish purification protocol and purify recombinant proteins from source cells.
  • Perform E. coli growth and recombinant protein expressions at liter-scale.
  • Document experimental data.
  • Communicate research priority, progress, and results with project teams.
  • Contribute to written and oral presentations related to research findings.
  • Provide technical and scientific guidance to junior research associates within the team.

BASIC QUALIFICATIONS

  • Bachelor of Science degree with 9+ years' or Master of Science degree with 7+ years' experience in protein crystallization and protein purification for crystallization.
  • An expert in protein crystallization resulted in diffracting crystals and high-resolution protein crystal structures.
  • Independent bench-scientist capable of purifying proteins at multi-mg scale; familiar with AKTA purifier system and standard analytical techniques associated with assessing protein purification process.
  • Experience in recombinant protein expressions in E. coli.
  • Strong organizational, problem-solving, and written/oral communication skills.

PREFERRED QUALIFICATIONS

  • Familiar with crystal handling and data collection at synchrotron facilities.
  • Experience with cryo-EM sample preparation protocols including negative staining and sample vitrification.


[Post Date: March 29, 2021]


Postdoc Positions in Structural Immunology

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Description:

The Brian Baker laboratory at the University of Notre Dame is looking for highly motivated postdoctoral fellows to join the structural immunology lab. The lab focuses on the intersection of protein structural biology, molecular biophysics, and molecular recognition and signaling in cellular immunity. Research in the laboratory blends molecular immunology with X-ray crystallography, biochemistry, and biophysics, and computational modeling, design, and simulation.

Big picture questions address fundamental mechanisms of immune recognition as well as cancer immunology and immunotherapy, autoimmunity and transplantation immunology, and T cell-based vaccine design and optimization. The laboratory is highly collaborative, working with experts in immunology and biophysics across the world, offering a tremendous opportunity for cross-disciplinary training.

 

Currently available projects center around:

 

  • Understanding, predicting, and manipulating T cell receptor specificity and cross-reactivity using combined experimental and in silico approaches.

https://pubmed.ncbi.nlm.nih.gov/30224695/ https://pubmed.ncbi.nlm.nih.gov/30617019/

 

  • Understanding the structural and physical rules that distinguish normal from abnormal immune recognition, such as autoimmunity and transplant rejection.

https://pubmed.ncbi.nlm.nih.gov/28572406/

  • Identifying the structural and physical features that promote T cell recognition of cancer neoantigens to improve the design of T cell-based vaccines.

https://pubmed.ncbi.nlm.nih.gov/32807968/

https://pubmed.ncbi.nlm.nih.gov/31555277/

Applicants with strong backgrounds and accomplishments in structural biology, structural modeling, and/or protein biophysics are welcome. Experience in mammalian cell culture is a strong plus. Familiarity with immunology is strongly preferred; in its absence, unbridled enthusiasm for learning how structure and biophysics impact immunology can substitute. Strong applicants with backgrounds in T cell immunology interested in developing as structural biologists are also welcome.

Interested applicants should contact Brian Baker at brian-baker@nd.edu or via Twitter at @ND_BakerLab. Visit the lab website at www.bmblab.org.

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[Post Date: March 25, 2021]


Research Associate III University of Arkansas for Medical Sciences

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Description:

Overview

The Research Associate III position is available to assist in the management of laboratory operations and to conduct scientific research, particularly in the area of our NIH-funded project of DNA replication. Laboratory management will include procuring laboratory supplies, assisting in the diagnosis and troubleshooting of laboratory equipment, reagents, or procedures and generating reagents for the entire research group. The scientific research responsibilities will be based on experience, needs, and interests.  These may include protein purification, molecular biology, biochemical assays, crystallization trials, and/or working towards cryo-EM structure determination with local and national facilities.

 

The University of Arkansas for Medical Sciences (UAMS) has a unique combination of education, research, and clinical programs that encourages and supports teamwork and diversity. We champion being a collaborative health care organization, focused on improving the health, health care, and well-being of Arkansans.

UAMS offers amazing benefits and perks:

  • Health: Medical, Dental and Vision plans available for staff and family
  • Holiday, Vacation and Sick Leave
  • Education discount for staff and dependents (undergraduate only)
  • Retirement: Up to 10% matched contribution from UAMS
  • Basic Life Insurance up to $50,000
  • Career Training and Educational Opportunities
  • Merchant Discounts
  • Concierge prescription delivery on the main campus when using UAMS pharmacy

Salary offered commensurate with experience

Responsibilities

  • Preparation of samples for structural analysis by protein expression and purification.
  • Generation of new protein expression constructs by molecular biology approaches, and screening samples for structural study. 
  • Independent analysis of structure following a period of on-the-job training. 
  • Duties will include biochemical assays such as DNA-unwinding and ATPase assays.
  • Placing orders (obtaining quotes, filling and submitting ordering forms, tracking order status and receiving orders).
  • Maintaining records of laboratory inventories (supplies).
  • Maintenance of laboratory equipment (centrifuges, chromatography equipment)
  • Training of new employees and/or students in basic laboratory techniques.
  • Overseeing staff compliance with the University, State and Federal guidelines for the safe operation of a laboratory.
  • Perform other duties as assigned.

Qualifications

Bachelor's degree in bioscience or related field plus seven (7) years of research experience required.

 

Preferred Qualifications:

Laboratory experience

 

UAMS is an Affirmative Action and Equal Opportunity Employer of individuals with disabilities and protected veterans and is committed to excellence.  If you need a reasonable accommodation for any part of the employment process, please contact us by telephone at (501) 686-6432 and let us know the nature of your request. We will only respond to messages left that involve a request for a reasonable accommodation in the application process. We will accommodate the needs of any qualified candidate who requests a reasonable accommodation under the Americans with Disabilities Act (ADA).


[Post Date: March 24, 2021]


Postdoc University of Arkansas for Medical Sciences

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Description:

Overview

A Post-Doctoral position is available in the Enemark lab for highly motivated applicants to study the structure and function of helicase proteins and their mechanism of action on nucleic acids. The laboratory is located in the Department of Biochemistry and Molecular Biology. The department is highly interactive with extensive expertise and interest in fundamental nucleic acids processes.

The University of Arkansas for Medical Sciences (UAMS) has a unique combination of education, research, and clinical programs that encourages and supports teamwork and diversity. We champion being a collaborative health care organization, focused on improving the health, health care, and well-being of Arkansans.

UAMS offers amazing benefits and perks:

  • Health: Medical, Dental and Vision plans available for staff and family
  • Holiday, Vacation and Sick Leave
  • Education discount for staff and dependents (undergraduate only)
  • Retirement: Up to 10% matched contribution from UAMS
  • Basic Life Insurance up to $50,000
  • Career Training and Educational Opportunities
  • Merchant Discounts
  • Concierge prescription delivery on the main campus when using UAMS pharmacy

Salary offered commensurate with experience

Responsibilities

  • Study the structure and function of helicase proteins and their mechanism of action on nucleic acids. 
  • Under the guidance of the scientific mentor, performs research techniques including but not limited to protein expression and purification, sample optimization, structure determination, and structure analysis. 
  • Attends and presents at national and international meetings and workshops. 
  • With Principal Investigator, may mentor or train graduate students, medical students, or undergraduate students.
  • Perform other duties as assigned.

Qualifications

Ph.D. or M.D. equivalent in a Bioscience or related field.

 

Knowledge,Skills & Abilities

  • Protein purification, cell culture, proteomics, and general laboratory experience.

  • Postdoctoral experience or relevant equivalent experience.

  • Experience protein crystallography and/or cryoEM.

  • Experience in biochemistry and a keen interest in structural biology.

UAMS is an Affirmative Action and Equal Opportunity Employer of individuals with disabilities and protected veterans and is committed to excellence.  If you need a reasonable accommodation for any part of the employment process, please contact us by telephone at (501) 686-6432 and let us know the nature of your request. We will only respond to messages left that involve a request for a reasonable accommodation in the application process. We will accommodate the needs of any qualified candidate who requests a reasonable accommodation under the Americans with Disabilities Act (ADA).


[Post Date: March 24, 2021]


Postdoc Structural Biology ESRF

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Description:

Context & Job description

As part of the Extremely Brilliant Source facility upgrade (https://www.esrf.eu/about/upgrade), the ESRF is constructing a new beamline for serial and time-resolved macromolecular crystallography (TR-)SSX experiments at room temperature. The new ID29 beamline will deliver an unprecedented flux density, allowing the recording of diffraction data from micron-sized samples in a few microseconds, and will be equipped with a next generation diffractometer and a Jungfrau detector. Beamline operations will be supported by a dedicated sample preparation laboratory where the most suitable crystal delivery systems such as injectors, fixed targets and microfluidic devices will be prepared and characterised prior to experiments.

The postdoctoral position available will focus on developing novel sample environments, delivery systems and data collection methods for (TR-SSX). These will, initially, be tested and commissioned at other ESRF MX microfocus beamlines. The selected candidate will also take part in the commissioning of the new ID29, performing state-of-the art experiments at the new end-station.

As for all post-doctoral researchers in the Structural Biology Group, the successful candidate will participate in in-house research programmes, will contribute to the operation of the beamline and will provide support to external users as local contact. He/She will also have the opportunity to develop his/her own research programme.

Further information may be obtained from Daniele de Sanctis (tel.: +33 (0)4 76 88 28 69, email: daniele.de_sanctis@esrf.fr).

Expected profile

  • PhD in chemistry, physics, biophysics, biology or closely related science obtained less than 3 years ago
  • A strong background in X-ray crystallography and serial crystallography is desirable
  • A strong interest in new method development
  • Ability to interact with multi-disciplinary staff and facility users
  • Proficiency in English (working language at the ESRF)

Working conditions

Contract of 18 months, renewable for a further 6 to 18-month period.

We offer a comprehensive benefits package designed to support your quality of life and your installation in the Grenoble area when relocation is needed.

The annual gross salary may be completed by additional allowances (shift allowance, standby allowance, expatriation allowance, etc.).


[Post Date: March 22, 2021]


Postdoctoral position in Structural Biology at the University of Toronto

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Description:

We are seeking an enthusiastic and self-motivated Postdoctoral Fellow to study macromolecular complexes involved in gamete fusion in the Lee Lab at the University of Toronto, Department of Laboratory Medicine and Pathobiology. The Postdoctoral Fellow will lead research efforts to perform structure-function studies of macromolecular complexes involved in the binding and fusion of human sperm and egg. The research will entail protein-protein interaction studies, crystallography and/or cryo-EM.

 

Qualifications:

  • PhD in Biochemistry, Structural Biology, or a related field
  • Experience with cloning, protein expression, and protein purification methods
  • Experience with insect or mammalian cell culture is a benefit
  • Solid practical and theoretical understanding in X-ray crystallography and/or cryo-EM
  • Strong publication record
  • Fluent in English (written and oral)
  • Strong scientific writing skills
  • Excellent problem solving, interpersonal, communication and presentation skills

The position is available immediately. University of Toronto is well equipped with state-of-the-art equipment for molecular biology, protein purification, biophysics and structural biology (crystallography, NMR and cryo-EM). Please visit the Lee Lab website (https://www.leelab-utoronto.com) for more information.

Interested candidates are invited to send your CV, a brief description of research interest and experience, names of three references by email to: Prof. Jeff Lee

jeff.lee@utoronto.ca

 

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[Post Date: March 19, 2021]


Postdoc Hydrogel Microsphere Technologies for Monoclonal Antibody Crystal Formulations

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Description:

Applications are invited for a Postdoctoral Scholar position in the Doyle Lab at MIT. The scholar will lead research efforts on an industrially sponsored project related to developing hydrogel microspheres for monoclonal antibody (mAb) formulations. The overarching goal of this project is to develop hydrogel-based formulations to enhance flow properties of injectable formulations and engineer the controlled release of mAbs[1]. The research will entail micro-and milli-fluidicproduction of microgel particles, rheometry, microscopy, and in vitrorelease studies. The postdoctoral associatewill have frequent interactions with the industrial collaborators.

Candidates should have experience in one or more of the following areas: microfluidic design & fabrication, rheometry, soft materials design & hydrogels, microscopy, protein crystallization, and data processing. Required skills include: strong background in the quantitative sciences or chemical/bio/mechanical engineering, and strong communication skills.

Applicants must have a demonstrated record of impactful scientific contributions and a capacity to communicate effectively with experts from a range of disciplines (including clinicians).Interviews are underway now, with the position to be filled immediately (or by end of June 2021, pending graduation/career plans of successful applicant).

To apply: Please email (i) your cover letter & CV and (ii) the names and contact information for 3 references to Prof. Patrick Doyle (pdoyle@mit.edu)“mAbPostdoc Application” in the subject line. MIT is an equal opportunity employerand we welcome diverse experiences, backgrounds and perspectives.

[1] Schieferstein, Narasimhan,Doyle, Advanced Therapeutics, 2000216, 2021.

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[Post Date: March 16, 2021]


Research Fellow position at A*STAR in Singapore

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Description:

We are seeking an enthusiastic and self-motivated postdoctoral research fellow to work in laboratory of structural  biology for signalling and diseases in Institute of Molecular and Cell Biology, A*STAR, Singapore. We take a combinatorial approach of molecular biology, biochemical and biophysical methods, and structural biology (crystallography and cryo-EM) to study proteins in the Hippo signaling pathway.Singapore is an excellent environment to do research with many research groups close by in Biopolis [https://www.a-star.edu.sg/imcb]. A*STAR offers highly competitive salaries with benefits including housing allowance and 1-3 months performance bonus. 

Requirements:

  • PhD in biochemistry, biophysics, molecular and cell biology or  a related field
  • Experience in Cryo-EM and/or X-ray crystallography or in molecular docking, compound design and molecular dynamics simulation 
  • Practical skills in molecular biology, protein expression (preferably insect and/or mammalian cells)and purification, and various biochemical techniques
  • Good publication record
  • Competent in scientific writing

Interested applicants should send a CV, publication list, a brief description of research interests and experience, and three confidential letters of reference to: Prof. Haiwei Song (Email: haiwei@imcb.a-star.edu.sg), Institute of Molecular and Cell Biology, A*STAR, Singapore. 


[Post Date: March 15, 2021]


Postdoctoral Position at NIH — Structures, Interactions and Mechanisms of Noncoding RNAs and RNPs.

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Description:

A fully funded postdoctoral position (up to 5 years) is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between the accelerated discovery and functional description of the noncoding transcriptome, and the lack of structural and mechanistic understanding of complex noncoding RNAs and RNPs. We seek a new member to join our diverse group to study gene-regulatory riboswitches, highly structured viral RNAs, long noncoding and circular RNAs and their complexes with other RNAs and immune proteins, etc. We develop and apply innovative technologies such as rational RNA design and engineering, RNA crystallography, RNA cryo-EM, XFEL, ultrafast SAXS/WAXS, single-molecule fluorescence, fluorescence lifetime, crosslinking-mass spec., etc. See https://www-mslmb.niddk.nih.gov/zhang/zhanglab.html and recent publications below for details:

Bou-Nader C. et al., & Zhang, J. (2021) Structural basis for host tRNA control of HIV-1 Gag localization., under review.

Suddala K.C & Zhang, J. (2019) High-affinity recognition of specific tRNAs by an mRNA anticodon-binding groove, Nat. Struct. & Mol. Biol., 26, 1114–1122.

Li S. et al., & Zhang, J. (2019) Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions, Nat. Struct. & Mol. Biol., 26, 1094–1105.

Hood, I.V. et al., & Zhang, J. (2019). Crystal structure of an Adenovirus Virus-Associated RNA, Nat. Commun. 10:2871

The well-supported lab has dedicated access to state-of-the-art equipment in structural biology (Mosquito, Dragonfly, Rock Imager, Akta Pures, FSEC, etc.; regular synchrotron access for X-ray crystallography; Titan Krios and Glacios for single-particle Cryo-EM; SAXS, AFM, NMR, etc), biochemistry, biophysics (ITC, DSC, SPR, BLI, AUC, DLS, SEC-MALS, CD, fluorescence, thermophoresis, iSCAMS, etc), fermentation, advanced mass spec, genomics and sequencing, and proteomics core facilities with hands-on training or service by dedicated PhD-level staff scientists.

Incoming fellows are also encouraged to bring your own ideas that you could develop into research programs that you can then take to your independent PI positions. The NIH, NIDDK, and LMB are committed to the continued education and career development of trainees through numerous courses and workshops offered by OITE, FAES, and NIDDK.

Requirements: Interested candidates must have received (or be expecting) a Ph.D. or M.D. within the past five years in molecular biology, structural biology, biochemistry, RNA biology, or a related discipline, have excellent oral and written communication skills, and be strongly self-motivated to design and participate in innovative and rigorous research projects. Prior experiences in structural biology are not required, as training will be provided.

To apply: Please email a cover letter indicating preferred start date, CV, a brief summary of research interests, accomplishments, and career goals, and names and contact information for at least three references to: Dr. Jinwei Zhang, Email: jinwei.zhang@nih.gov. The NIH is dedicated to building a diverse community in its training and employment programs. DHHS/NIH is an Equal Opportunity Employer. 


[Post Date: March 11, 2021]


Postdoctoral Fellow in Structural Biology

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Description:

About this position

The laboratory of structural biology of macromolecular protein-RNA complexes (Dr. Eva Kowalinski) at the EMBL Grenoble is looking for a postdocal fellow. The thriving group uses a multidisciplinary approach to tackle complex biochemical questions by combining state-of-the art cryo-EM, X-ray crystallography and other biochemical, biophysical methods and cell biology. In the group, we believe in growing with our challenges, life long learning and team play.

Your role

We are seeking a highly motivated and ambitious individual to join our investigations into the structure and function of RNA-protein complexes involved in RNA modification and editing. The open project includes the structural elucidation of new RNA modification mechanisms via structural, biochemical and cell biology methods and might move in the direction of early stage drug discovery.

You have

The successful candidate holds a PhD in Molecular Biology or a related field, has published in scientific journals and is willing to apply for prestigious fellowships.

Experience in molecular biology techniques, including cloning, protein expression, purification, biochemistry, cell culture as well as expertise in X-ray crystallography or cryo-EM are expected.

Why join us

Why not! Well, EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises from a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family.

The Kowalinski lab at the EMBL Grenoble has access to world-class infrastructure offered by the inter-institutional Partnership for Structural Biology PSB Grenoble (www.psb-grenoble.fr). Access is granted to in-house bacterial, insect and mammalian cell expression facilities, parasite cell culture, confocal microscopy and the high-throughput crystallization facility and all core facilities at the EMBL headquarters. Electron microscopic infrastructure is available: EMBL Grenoble in-house Tecnai T12 and Glacios (200keV, Falcon3) and regular access to the Electron Microscopy Core Facility (EMCF) at EMBL Heidelberg with various high-end microscopes and the ESRF Titan Krios (K2, phase plate). X-ray infrastructure: regular access to ESRF (on campus) and access to other European synchrotrons (DLS, PETRA, SOLEIL).

What else you need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1600 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.

Please submit your letter of motivation, your CV, and up to two references with the application. The reference letters can as well be submitted directly to kowalinski@embl.fr. Emailing your application is not necessary.

For any additional information please contact Eva Kowalinski directly (kowalinski@embl.fr) or visit our website: https://www.embl.org/groups/kowalinski/


[Post Date: March 11, 2021]


Postdoc in Drug Discovery Vanderbilt University

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Description:

An opening is available in the drug discovery laboratory of Dr. Stephen Fesik for a post-doc in the field of protein x-ray crystallography.  Responsibilities will include protein expression and purification, and all aspects of x-ray crystallography including preparation of protein-inhibitor complexes, crystallization, home/synchrotron data collection, and structure determination. Additional experiences in molecular biology including construct design, cloning, site-directed mutagenesis, and experience with recombinant protein expression in eukaryotic cells are highly preferred.  The ideal candidate should be self-motivated and be able to communicate efficiently in a highly collaborative environment. Please send cv to jason.phan@Vanderbilt.Edu


[Post Date: March 8, 2021]


Senior Scientist in Crystallography

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Description:

WuXi AppTec HitS unit (https://hits.wuxiapptec.com/) provides one-stop Target-to-Hit services to enable companies in pharmaceuticals, biotechnology and academia to pursue their goals in drug discovery. As an innovation-driven and customer-focused unit, WuXi AppTec HitS provides solutions to help partners improve the productivity of hit discovery activities. With industry-leading capabilities such as protein science, biophysics, DNA-encoded library technology, and structure-based drug design, WuXi HitS is committed to drive toward the realization of the vision that every drug can be made and every disease can be treated.

We have various openings from talented Technicians to Senior Scientists to strengthen our protein crystallization team in Suzhou.

We are looking for protein crystallographers to prepare protein samples for crystallization and develop strategies for the optimization of protein crystals that are relevant in drug discovery in the pharmaceutical industry. Qualified candidates will also be involved in computational crystallography and structure determination.

As a successful candidate you have hands-on experience with protein purification and handling and have a good understanding of the requirements for a successful crystallization of proteins and protein complexes. Experience with the crystallization of membrane proteins is a plus.

You are familiar with state-of-the-art liquid handling robotics in protein crystallization as well as mounting of protein crystals and collecting x-ray diffraction data on in house or synchrotron radiation sources.

The successful candidates will work in an international and highly collaborative environment. You will interact closely both with the protein purification groups in Suzhou and Munich/Germany as well as the HitS teams at our Shanghai facilities.

Requirements include, depending on the position you are applying for:

  • PhD in Structural Biology, Biochemistry or Biophysics, with expertise in protein X-ray crystallography, or Master’s degree with extensive Structural Biology experience.
  • Demonstrated track record of achievement through publications and PDB depositions.
  • Hands-on experience and knowledge of state-of-the-art protein crystallography techniques including all aspects of gene-to-structure process.
  • Experience in protein characterization by modern biophysical techniques is a plus.
  • Excellent written and verbal communication skills in both English and Chinese preferred.
  • Ability to multi-task and deliver results in a timely manner are essential.

To apply for this position, please send your CV to liu_yuanshu@wuxiapptec.com with the subject: “Senior Scientist in Crystallography”


[Post Date: March 8, 2021]


Postdoc Position at Fox Chase Cancer Center

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Description:

A postdoctoral fellow position is available at the Molecular Therapeutic Program Fox Chase Cancer Center (Philadelphia, PA) for a highly-motivated individual in the field of structural biology and molecular biology.

The main focus of the lab is to elucidate the molecular mechanisms underlying cell adhesion and migration that are mediated by integrin signaling and/or small GTPase signaling. We employ a combination of techniques including protein crystallography, electron microscopy, binding kinetics analysis, functional assays in mammalian cells, and genetic analysis. Our study will facilitate efforts to discover novel targets for therapeutic intervention of immune system disorders, tumor metastasis, and many other related diseases. More details can be found at https://www.foxchase.org/people/jinhua-wu. The lab is equipped with a Mosquito® crystallization robot, a Rock Imager for automatic crystal imaging, an in-house X-ray diffractometer, three AKTA purification systems, and other general biochemistry equipment.

The candidate should be experienced in protein biochemistry, X-ray crystallography, and molecular biology. Prior experiences in cell signaling and cancer biology are desired but not required. Fox Chase Cancer Center is a long-standing NCI-designated Comprehensive Cancer Center with multidisciplinary research interests from basic biological sciences to drug development and clinical studies. The institute is one of the top-ranked work places for visiting scholars and postdoctoral researchers. Fox Chase strictly follows the NIH guideline for the salary level of all postdoctoral researchers. We also offer an outstanding research environment and strong support for the career development for our scientists.

Please send a cover letter describing previous research experience and current interests, a current CV, and a list of three references to: Jinhua.wu(at)fccc.edu.


[Post Date: March 5, 2021]


Postdoc Case Western Reserve University School of Medicine

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Description:

Postdoctoral positions in membrane protein structural biology are immediately available in the Tajima Lab, in the Department of Physiology and Biophysics at Case Western Reserve University School of Medicine. We seek self-motivated and creative structural biologists. 

 

We focus on 

1. understanding the molecular mechanisms of ion channels that play a pivotal role in synaptic transmission.

2. dissecting the signaling pathways in the CNS in health and disease.

3. structure-based drug discovery.

 

These issues will be addressed using a multidisciplinary approach, including structural biology, patch-clamp electrophysiology, molecular and cellular biology, and biochemistry/biophysics. Case Western Reserve University is equipped with a state-of-art structural biology facility, including FEI Titan Krios (with phase plate, energy filter, and a K3 detector), FEI Tecnai TF20 & T12 screening microscopes, and the high-performance data analysis infrastructure. The department also has core facilities for protein expression/purification, X-ray crystallography, proteomics&mass spectrometry, and electrophysiology. The successful candidates will enjoy a collaborative environment with cutting-edge instruments. 

 

Applicants should hold (or will be shortly awarded) a PhD degree and have experience in molecular biology and protein purification. Experience in single-particle Cryo-EM/X-ray crystallography is probably a better fit for this position. Please send a cover letter describing research interests, a CV, and contact information for 2-3 references to Nami Tajima at nxt193@case.edu.

 

Additional information about the group can be found here:

https://sites.google.com/case.edu/tajimalab/home

https://physiology.case.edu/people/faculty/nami-tajima/


[Post Date: March 4, 2021]


Postdoctoral Positions in Time-resolved Crystallography

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Description:

The Standfuss group at the Paul Scherrer Institute is offering two postdoctoral positions in time-resolved serial crystallography using the Swiss Light Source and the Swiss X-ray Free Electron laser. We are looking for a candidate with computational/crystallography background and one with a focus on membrane protein purification and crystallization techniques. Together with an interdisciplinary team of scientists and in collaboration with our industrial partner leadXpro you will study the dynamics of ligand-protein interactions in G protein-coupled receptors.

Please find more details using the links below:

Inserat 2316-00 Biochemist: 

https://www.psi.ch/en/pa/job-opportunities/44148-postdoctoral-fellow

Inserat 2316-01 Crystallographer:

https://www.psi.ch/en/pa/job-opportunities/44151-postdoctoral-fellow


[Post Date: March 2, 2021]


Postdoc Positions in Structural Analysis of Trypanosome Kinetochores, University of Oxford

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Description:

Two postdoc positions are available in my group at the Department of Biochemistry, University of Oxford.

We are seeking to appoint two outstanding individuals with PhD training in structural biology to reveal the structure and function of unconventional kinetoplastid kinetochore proteins. Although it was widely believed that all eukaryotes would have a conserved set of kinetochore proteins, we identified more than 20 uncharacterized kinetochore proteins (named KKT1–25) in Trypanosoma brucei and discovered that they constitute unconventional kinetochores specific to kinetoplastids, a group of evolutionarily-divergent eukaryotes (Akiyoshi and Gull, Cell 2014, Nerusheva and Akiyoshi Open Biol 2016, Nerusheva et al., Open Biol 2019, Tromer et al., bioRxiv 2021). We are currently characterizing these KKT proteins using various techniques including cell biology, bioinformatics, super-resolution microscopy, biochemistry, biophysics, and structural biology (X-ray crystallography, NMR, electron tomography, and cryoEM/ET).

For more information, please click on the link below:
https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.jobspec?p_id=149534


[Post Date: March 2, 2021]


Postdoctoral Positions to Study Host-pathogen Interactions

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Description:

We are recruiting 2-3 postdoctoral fellows to join the group of Muthiah Kumaraswami in the Department of Pathology and Genomic Medicine. The projects will seek to elucidate the role of quorum sensing pathways in host-pathogen interactions and pathogen commensal interactions. The candidate will employ a multidisciplinary approach to dissect the mechanisms of bacterial signaling pathways and understand the contribution of such signaling pathways to bacterial pathogenesis. The fellow will use a variety of genetic, biochemical, biophysical, structural, and mouse infection methods to identify novel cellular processes involved in bacterial pathogenesis with the long-term goal of targeting these processes for antibiotic development. Some of the key areas we are currently investigating include the bacterial communication pathways, bacterial sensory systems regulating metal acquisition, and vaccine development studies.

Qualifications and Experience
Qualified candidates will have (or be about to obtain) a Ph.D. degree. The candidate is expected to have experience in basic microbiology methods, animal infection studies and preferably knowledge on protein chemistry and structure. The ability to work in a team, and good organizational and communication skills in English are also desired. Applicants should send a CV with a description

Houston Methodist Research Institute (HMRI) is located at the center of Texas Medical Center, the largest medical center in the world. The institution is surrounded by other world-renowned institutions such as Baylor College of Medicine, M.D. Anderson Cancer Center, Rice University,
and University of Texas Health Sciences center.  

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[Post Date: March 2, 2021]


Postdoc in Structural and Chemical Biology

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Description:

A postdoctoral position is available for joining a dedicated team of scientists working at the interface of chemistry and biology to generate new classes of tool compounds and leads for cancer drug discovery. The position is in the Dar laboratory at Mount Sinai in New York City. The lab is located in the Hess Center for Science and Medicine, which provides a rich environment for scientific interactions, collaborations, and state of the art facilities. An extensive program of seminars, symposia and other organized meetings on campus focused on a large array of topics in cancer, chemical biology, cardiovascular research, and neuroscience provides broad exposure to biology and medicine. Mount Sinai benefits for postdocs include housing options within Manhattan. If interested, please respond with your CV, a description of past research experiences, and references to arvin.dar@mssm.edu

For a recent example of work from the lab, please see: https://www.nature.com/articles/s41586-020-2760-4

Additional information on the lab can be found at: http://www.mountsinai.org/profiles/arvin-dar


[Post Date: March 2, 2021]


Postdoc Washington University in St. Louis

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Description:

A postdoc position is immediately available for a highly motivated individual to study the structural mechanisms of integral membrane enzymes, transporters and adhesion molecules that are important therapeutic targets in hematology, immunology, and cardiovascular biology. To support the study, Dr. Weikai Li’s lab at Washington University in St. Louis has developed multidisciplinary approaches that combine novel structural biology and mass spectrometry methods with biochemistry and cell biology. Recent publications of the lab include those in Science, Science Adv., EMBO J and NSMB. The lab is well funded by five grants from NIH and other foundations, which can support the entire duration of postdoctoral study (5 yr) and subsequent promotion. More information of the lab can be found at https://weikailab.wustl.edu.


Requirements and Responsibilities
The postdoc candidate should have strong publication record and background in structural biology and biochemistry. Previous experience with cryo-EM or membrane proteins is favorably considered. The lab culture encourages free exploration, and the fellow is welcome to develop their own research projects and strategies that are of mutual interest. High degrees of motivation and independency are greatly appreciated. On the other hand, the PI is always available to provide advices.


Research Environment: The Washington University Medical School is top ranked in the US. The Li lab is well established and equipped in the structural biology, mass spectrometry, biochemistry, and cell biology studies of membrane proteins, and has developed novel methods for these studies, such as live cell footprinting (NSMB 2007) and fast structure determination (Sci. Adv. 2020). For cryo-EM, the lab gets regular time (about one week in every two months) in using Washington University’s own Titan Krios. Screening and data collection on Glacios 200Kv is readily accessible. Crystallization robots and regular APS time are available for crystallography studies. Close collaboration with Dr. Michael Gross lab affords us extensive access to mass spectrometry analyses.

Please send your CV, the name of three references, and a brief email detailing your research interest to weikai@wustl.edu.

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[Post Date: March 2, 2021]


Postdoctoral Research Associate BioSciences at Rice

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Description:

An NIH-funded postdoctoral position is available in the Shamoo lab (Department of BioSciences at Rice University). Our research is focused on the structural and biochemical basis for antimicrobial drug resistance by multi-drug resistant pathogens. Successful candidates are expected to have experience in protein purification, crystallization and structure determination. The breadth of research in our group is very broad extending from in vitro experimental evolution, genotype to phenotype mapping at the cellular level all the way to macromolecular crystallography so lab members must be able to work well with others from diverse research areas. Applicants must have a Ph.D and experience in a relevant area of structural biology. Ancillary areas of knowledge in biochemistry, cryoEM  and/or membrane protein characterization could also be helpful. 

If you are interested in the lab here is our website: https://shamoolab.rice.edu/

Applicants must apply through the university posting at: https://jobs.rice.edu/postings/25590


[Post Date: February 24, 2021]


Postdoctoral Research Associate Structural Biology

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Description:

The National Synchrotron Light Source II (NSLS-II) has an opening for a post-doc to participate in multi-disciplinary research to help provide a molecular structural view of the mechanisms of nitrogenase-like enzymes. Collaborators at the Ohio State University have identified a previously uncharacterized enzymatic system that uses a nitrogenase-like reductase that is distinct from known nitrogenases and nitrogenase-like reductases. The work is supported by the DNA Synthesis Science program at the DOE Joint Genome Institute. Working in a multi-disciplinary, multi-national, team the candidate will carry out research using a macromolecular crystallography, solution scattering and cryogenic electron microscopy. This work will help establish a broader understanding of the molecular structures involved in electron delivery and catalytic reduction in this enzyme class.

Brookhaven National Laboratory is entering an exciting new chapter with one of the newest and most advanced synchrotron facilities in the world. National Synchrotron Light Source II (NSLS-II) enables the study of material properties and functions with nanoscale resolution and exquisite sensitivity by providing world-leading capabilities for X-ray imaging and high-resolution energy analysis.

This facility is open to users from academia and industry and its operations are at a time when the world enters a new era with a global economy fueled largely by scientific discoveries and technological innovations. NSLS-II provides the research tools needed to foster new discoveries and create breakthroughs in critical areas such as energy security, environment, and human health.


[Post Date: February 24, 2021]


Postdoc Princeton University

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Description:

Postdoc positions are available immediately or when you are ready in the Alexei V. Korennykh Group in the Department of Molecular Biology at Princeton University.

Research topics: antiviral immune system, mammalian stress response, RNA biology, structural biology of emerging mitochondrial pathways.

Methods we use: X-ray crystallography, Cryo-EM, RNA and protein biochemistry, RNA-seq, mammalian cell biology, CRISPRs.

If you have background and interest in one or more of these areas, you are most welcome to send an email directly to Alexei: akorenny@Princeton.EDU

To get familiar with our work please visit https://scholar.princeton.edu/korennykhlab/home and https://pubmed.ncbi.nlm.nih.gov/?term=Korennykh&sort=date.


[Post Date: February 23, 2021]


Postdoctoral Researcher 2021 (Al-Bassam Lab)

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Description:

We are recruiting a talented postdoctoral fellow to join our group at the University of California-Davis to study the structural mechanisms of multi-subunit assemblies that mediate tubulin heterodimer biogenesis and accelerate tubulin polymerization at microtubule ends. Our group also studies the structural mechanisms of mitotic kinesin motor activation.  Our laboratory combines biochemical characterization, single particle cryo-EM and/or X-ray crystallography, as well as single molecule reconstitution assays to generate a mechanistic understanding spanning multiple resolution scales. Our laboratory has well-developed setups for all the above approaches (http://microtubule.mcb.ucdavis.edu).

The UC-Davis BIOEM facility is well-setup for cryo-EM sample preparation, using a Thermofisher Vitrobot and a Leica GP2, and for cryo-EM imaging using an automated Thermofisher 200-KV Glacios microscope equipped with an autoloader and a Gatan K3 direct detector for high throughput data collection (https://bioem.ucdavis.edu/).

The suitable candidate should have a PhD in chemistry, biochemistry or biophysics with training in molecular biology / biochemistry and structure determination expertise either using single particle cryo-EM, and/or X-ray crystallography.

To apply and access full details of the position at https://recruit.ucdavis.edu/JPF04018


[Post Date: February 23, 2021]


Postdoctoral Associate Applications of Pressure to Structural Biology

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Description:

The Macromolecular Diffraction and High Pressure Biology resources at the Cornell High Energy Synchrotron Source (MacCHESS and CHEXS/HP-Bio, respectively) have an opening for a Postdoctoral Associate to develop applications of high pressure to answer biological questions concerning enzyme mechanisms, protein folding, adaptation to extreme environments, and the origin of life. The primary method to be used is pressurization of macromolecular crystals in a diamond anvil cell (HP-MX), but other techniques such as high-pressure small angle X-ray scattering (HP-SAXS) will also be available.

A Ph.D. degree in structural biology, biophysics, or a related field is required. Experience in crystallography is highly desirable, and experience working with samples in "non-standard" environments is a plus. The ability to identify suitable systems for study, through researching previous work and establishing suitable collaborations, is essential. In addition to pursuing his/her own study of pressure effects, the successful candidate will be expected to assist research groups seeking to use high-pressure techniques at CHESS for their work.

Please apply for the position here: https://academicjobsonline.org/ajo/jobs/18189


[Post Date: February 23, 2021]


Postdoc Strucutral Biology Aarhus Universitet

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Description:

3 year postdoc position available in the Andersen Group at Aarhus Universitet (https://mbg.au.dk/en/research/research-areas/plant-molecular-biology/kasper-roejkjaer-andersen/) studying structural and functional aspects of receptors and signalling components important for plant-microbe interactions. We recently obtained structures of a symbiotic receptor (Bozsoki, Science 2020) and a surveillance receptor (Wong, Nature Comm. 2020) and the postdoc project builds on these advances and will use structural biology (cryo-electron microscopy/X-ray crystallography) and biophysical methods to expand our knowledge on how receptors form larger complexes and how pathway components decode this in symbiosis signalling.


[Post Date: February 23, 2021]