Banner Image

Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Protein Crystallographer Syngenta

View the Job Posting Here

job posting image

Description:

We are looking for a motivated and independent protein crystallographer with Masters or PhD level qualifications ideally having worked with different crystallization systems. Based in Jealotts Hill, Berkshire, this position is an ideal opportunity for scientists interested in a career in industry to gain practical industry experience, working on crystallography platform activities and research projects. Prior experience of protein crystallization and optimization is essential, whilst data collection using both in-house and synchrotron sources as well as refining protein:ligand complexes would be preferred.

The successful candidate will work as part of a team providing crystallization outputs to support chemistry design throughout R&D. Excellent oral and written communication skills and the ability to work in multidisciplinary project teams are highly desirable qualities for this position.

Responsibilities

  • Carry out crystallization trials, crystal optimization and initial characterization by X-ray diffraction for proteins and protein-ligand complexes 
  • Effectively communicate results through presentations, e-mails and reports
  • Share learnings and insights with the team in a timely manner
  • Organisational duties around lab hardware and consumables

Experience required

  • PhD or MSc degree in structural biology or a related field
  • 1-3 years experience in practical macromolecular crystallography, ideally across a wide range of protein families
  • Knowledge of protein crystallization and optimization techniques

About Syngenta

Syngenta is one of the world’s leading companies with more than 27.000 employees in over 90 countries dedicated to our purpose: Bringing plant potential to life. Through world-class science, global reach and commitment to our customers we help to increase crop productivity, protect the environment and improve health and quality of life. For more information about us please go to http://www.syngenta.com/.

For any informal enquiries, please don't hesitate to get in touch at jenny.moore@syngenta.com, otherwise I look forward to receiving your application through the following link: https://www.srg.co.uk/jobs/j32696-protein-crystallographer


[Post Date: July 19, 2019]


Postdoc Rice University Houston

View the Job Posting Here

job posting image

Description:

A postdoctoral position is immediately available in Dr. Yang Gao’s lab at Rice University, Houston. The Gao lab utilizes structural biology techniques to investigate the molecular mechanisms of DNA replication, repair and recombination. We employ cryo-electron microscopy, x-ray crystallography, and various biochemical and biophysical approaches to characterize how enzymes and motors work together to accomplish these elaborate processes (see Gao’s recent publications https://science.sciencemag.org/content/352/6291/1334.short, https://science.sciencemag.org/content/363/6429/eaav7003.abstract and https://scholar.google.com/citations?user=y296jScAAAAJ&hl=en). The postdoctoral fellow will be involved in investigating the structural basis of Mitochondria DNA replication, with cryo-electron microscopy as the major technique. He/She will carry out in vitro reconstitution and biochemical and structural characterizations of the Mitochondria DNA replication system.

Applicants should have a Ph. D. degree in biochemistry, structural biology or related field. Experience in cryo-electron microscopy is a plus but not required. To apply, please email Dr. Yang Gao at yg60@rice.edu or apply through http://jobs.rice.edu/postings/20510.


[Post Date: July 19, 2019]


Postdoc University of Oklahoma-Norman

View the Job Posting Here

job posting image

Description:

Biochemist or Structural Biologist: Seeking a highly motivated postdoc with experience in one or more biochemical techniques involving cloning, protein expression, purification, biochemical assays, X-ray crystallography, structure calculations, and functional characterization of enzymes. The ideal applicant should have a Ph.D. in Biochemistry or related area. The candidate should have expertise in determining X-ray structures of enzymes, functional characterization, and engineering studies for their potential as biocatalysts for drug development. The focus of the position is to contribute to our ongoing interrogation of substrate specificity and synthetic utilities of prenyltransferases.  If you are interested in applying, please email your CV to shanteri.singh@ou.edu

Research Overview in Singh Group

Research in the Singh laboratory lies at the interface of chemistry and biochemistry. We use tools and methods from biochemistry and structural biology to characterize new enzymes from natural product biosynthetic pathways; molecular biology techniques to engineer enzymes to generate better biocatalysts; and synthetic chemistry methods for the generation of precursors necessary for natural product diversification. The fundamental goal of research in Singh laboratory is to understand and exploit natural product enzymes for developing biologically active molecules against cancer and infectious diseases. Our lab is especially interested in exploiting the ability of late stage enzymes from natural product biosynthetic pathways for the structural diversification of complex natural products. Despite the fact that structural diversification of biologically active molecules by attaching different chemical moieties has great potential to generate new drug leads, chemical methods often suffer from selectivity and tedious purification steps. Our goal is to exploit the potential of natural product enzymes and generate chemoenzymatic-tools for facile attachment of chemical moieties in a stereo- and regio- selective fashion to complex molecules towards the generation of biologically active compounds. 


[Post Date: July 18, 2019]


Senior Scientist EVOTEC

View the Job Posting Here

job posting image

Description:

Evotec is a global, publicly listed biotechnology company with more than 2,700 employees at 13 sites, our headquarters are located in Hamburg. We do research on innovative approaches to drug discovery and development for and with leading pharmaceutical and biotechnology companies and academic institutions. By assembling top-class scientists, state-of-the-art technologies as well as substantial experience and expertise in key therapeutic areas including neuroscience, diabetes and complications of diabetes, pain and inflammation, oncology and infectious diseases, Evotec has established a unique leading position.

  • Required knowledge, skills and abilities:
  • Extensive knowledge in protein biochemistry and macromolecular crystallography
  • Experience with protein purification
  • Protein engineering, bioinformatics and molecular biology (Construct design and cloning strategy)
  • Familiar with Biophysic techniques (DSF, ITC…)
  • A working knowledge and practical experience with either E. coli, insect or mammalian expression systems
  • The successful candidate will have experience working in multi-disciplinary teams
  • Experience collaborating with scientists in external organisations

Responsibilities includes:

  • Reading scientific literature relevant to the project
  • Supporting a project team by designing and ordering constructs to initiate the project
  • Adapting scientific knowledge to resolve problems encountered in achieving defined goals with assistance from line manager or other team members to meet internal and project deadlines
  • Preparing reports, presenting data, and collaborating with other scientists at Evotec
  • Presenting own work at project technical meetings, and department technical meetings when required
  • Demonstrating full command of all techniques and tools required for assigned responsibilities within the given project
  • Ensuring safe working practices of themselves and any direct reports
  • Complying fully with the company safety policy (including COPs and SOPs) when performing experiments
  • Adhering to Lab Notebook guidelines regarding accurate documentation of lab experiments

Desirable Knowledge, Skills and Abilities:

  • Experience in Cryo-EM
  • Self-motivated, enthusiastic, cooperative and reliable
  • Knowledge of basic laboratory techniques, and understanding of the science underlying the techniques and experiments
  • Experience of working in a lab environment
  • The ability to adapt to changing demands whilst operating under pressure to deadlines
  • The ability to work accurately and with attention to detail
  • Good interpersonal skills and the ability to work well with other scientific staff
  • The ability to work well independently, and as part of a team
  • Good organisational and time management skills
  • Good verbal communication skills
  • Ability to maintain excellent laboratory records
  • Computer proficiency

Education & Experience:

  • PhD degree in Structural Biology, Biochemistry or related area


[Post Date: July 18, 2019]


Postdoc at CSHL - Furukawa Lab

View the Job Posting Here

job posting image

Description:

The laboratory of Hiro Furukawa at Cold Spring Harbor Laboratory (CSHL) is seeking a postdoctoral fellow with dynamic interests in solving questions in molecular neuroscience and neurological diseases using multidisciplinary approaches. Our group currently conducts structural biology (cryo-EM/crystallography) on cell surface receptors and ion channels to gain mechanistic insights and develops reagents against those membrane proteins (e.g. small compounds and antibodies) to regulate neuronal functions for research and therapy. We use diverse techniques to analyze functions including patch-clamp/bilayer electrophysiology, fluorescence imaging, calorimetry, and phage/yeast display. We have an access to the state-of-the-art equipment including Titan-KRIOS 300 Kev electron microscope/K2-GIF detector (soon to be upgraded to K3-GIF) at CSHL, crystallography tools such as Mosquito LCP and Dragon fly, frequent access to synchrotron light sources including NSLS-II and excellent facility for phage/yeast display, proteomics, and light microscopy. CSHL offers a unique scientific environment to interact with scientists within the institute as well as from outside at the prestigious CSHL courses and meetings (including courses on the X-ray Methods in Structural Biology, Cryo-EM, and Ion channels). The Furukawa lab has a good recent track-record for educating/promoting postdocs to assistant professors in academia and equivalent positions in industry. A qualified candidate should hold or soon expect to hold (within ~1 yr) Ph.D. in the area of structural biology, biochemistry, molecular biology, computational biology, molecular neuroscience/electrophysiology (patch-clamp, imaging, etc), or related fields. Please visit our website (https://www.cshl.edu/research/faculty-staff/hiro-furukawa/) to read and learn about the lab. Please send a CV with a brief research statement as well as 2-3 contacts for references to Hiro Furukawa at furukawa@cshl.edu.


[Post Date: July 17, 2019]


Postdoctoral Researcher, University of Lethbridge, Canada

View the Job Posting Here

job posting image

Description:

A postdoctoral researcher position is available at the Medicinal Biophysics Laboratory, led by Dr. Trushar Patel, to study the RNA-protein and protein-protein interactions that play crucial roles in viral replication and cell signaling. The candidate will perform cell biology, biophysical and mass spectrometry assays.

Motivated researchers with a recent Ph.D. in biochemistry, biophysics, and/or cellular biology are encouraged to apply. It is expected that the candidate will have proven their research accomplishments by peer-reviewed publications. Mass Spectrometry experience is an asset. Interested candidates should send a CV including the names of at least three referees, a motivation letter and links to publications by email to trushar.patel@uleth.ca.

Our laboratory is based at the state-of-the-art Science and Academic Building (http://www.destinationproject.ca) at the University of Lethbridge. Lethbridge is located in Southern Alberta, not far from the Rocky Mountains, the city of Lethbridge enjoys a sunny, dry climate that is surprisingly mild, has excellent cultural and recreational amenities, and offers attractive economic conditions. The University is situated on the west side of Lethbridge and stretches across the coulees, with a great view of the Oldman River valley.


[Post Date: July 17, 2019]


Postdoc at IGS Aix-Marseille University

View the Job Posting Here

job posting image

Description:

The IGS laboratory (http://www.igs.cnrs-mrs.fr) is offering 2 Post-doc positions for 1 year, renewable up to 3 years, in the context of the ERC project “VIREVOL - Cells and giant viruses: a win-win co-evolution”.

The project aims at elucidating how the Mimiviridae genome is packed inside the virus capsid and which is the role of the packaging ATPase in the compaction of DNA into a rod-shape helicoidal structure.

Requirements:

PhD in physics, biophysics, biological sciences, biochemistry Proven track records in membrane protein structural and functional analysis Prior experience in cryoEM and/or macromolecular crystallography is a plus

The positions will start by the end of October 2019 or January 2020, at the latest.

To apply, please send your CV with a complete list of publications, one motivation letter and 1-2 reference letters to Dr Chantal Abergel (chantal.abergel@univ-amu.fr).


[Post Date: July 16, 2019]


Research Technician Gonen Lab UCLA

View the Job Posting Here

Description:

There is an exciting opportunity for a research technician to join the Gonen lab at UCLA, supporting ongoing projects in membrane biophysics and biochemistry. This role will perform research using biochemical and molecular biology techniques.

The Gonen Lab at the University of California works toward understanding how membrane proteins help cells maintain homeostasis. To that end we study channels, transporters, and receptors structurally and functionally.


[Post Date: July 15, 2019]


Two postdoctoral positions at the Walter and Eliza Hall Institute, Melbourne

job posting image

Description:

We are seeking two talented and enthusiastic postdocs to join teams within the Inflammation Division of the Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia: one focused on structural biology+cell biology; and another postdoc to study protein-protein interactions.

1. A postdoc or senior postdoc to study the structural and cell biology of pseudokinases, with a focus on the necroptosis effector MLKL

https://www.wehi.edu.au/research-officer-senior-research-officer-postdoctoral-scientist

Enquiries to jamesm@wehi.edu.au

2. A postdoc to study the interactions of signaling proteins using biophysics and proteomics.

https://www.wehi.edu.au/research-officer-postdoctoral-scientist

Enquiries to snicholson@wehi.edu.au


[Post Date: July 10, 2019]


PostDoc Position at the Wohl Institute of King’s College London

Description:

We are looking for a young and dynamic person post-PhD willing to carry out an interesting and challenging project of Structural Biology at the Wohl Institute of King’s College London. The Wohl is an institute opened in 2015 and devoted to the study of Neuroscience from a multidisciplinary point of view. Our group works within the tradition of Structural Biology established at King’s College London which sees among its alumni Rosalind Franklin, Maurice Wilkins, Alex Stokes, Herbert Wilson and John Randall. We aim to solve the structure of ARPP21, a protein involved in neuronal development and, when mutated, in amyotrophic latheral schlerosis, and determine its properties in aggregation. ARPP21 is a mixed folded protein which contains potentially structured domains and intrinsically unfolded regions. The successful candidate will have access to all the superb facilities of the Wohl, Randal and Crick Institutes. These include several NMR spectrometers ranging from 600 to 950 MHz, advanced optical spectroscopies, crystallization robots and many other tools in support of structural and integrated biology.

Enquiries to Annalisa.pastore@crick.ac.uk


[Post Date: July 10, 2019]


Research Fellow Position in Singapore

View the Job Posting Here

job posting image

Description:

We are seeking an enthusiastic and self-motivated postdoctoral research fellow to study proteins involved in maintaining genome stability and the Hippo signaling pathway. We take a combinatorial approach of molecular biology, biochemical and biophysical methods, and structural biology (crystallography and cryo-EM). ¬Significant aspects of our projects have translational potential. Candidates with an interest in the development of small molecules/peptides for cancer therapeutics are also welcome.

Singapore is an excellent environment to do research with many research groups close by in Biopolis [https://www.a-star.edu.sg/imcb]. A*STAR offers highly competitive salaries with benefits including housing allowance and 1-3 months performance bonus.

Requirements:

•       PhD in biochemistry, biophysics, molecular and cell biology or a related field

• Solid practical experience in Cryo-EM and/or X-ray crystallography

• Practical skills in molecular biology, protein expression (preferably insect and/or mammalian cells) and purification, and various biochemical techniques

•       Good publication record

•       Competent in scientific writing

Interested applicants should send a CV, publication list, a brief description of research interests and experience, and three confidential letters of reference to: Prof. Haiwei Song (Email: haiwei@imcb.a-star.edu.sg), Institute of Molecular and Cell Biology, A*STAR, Singapore.


[Post Date: July 10, 2019]


Research Associate Opening at NE-CAT, at the APS

View the Job Posting Here

Description:

The Northeastern Collaborative Access Team (NE-CAT), located at the Advanced Photon Source at the Argonne National Laboratory in suburban Chicago, is seeking applicants for a beamline scientist position. The primary responsibilities of the staff scientist will be to provide user training and support using NE-CAT’s X-ray beamlines; assist in setting up experiments; provide crystallographic expertise to ensure the highest quality data and structures; and contribute to the continued development of software tools.

Duties and Responsibilities:

•       Provide user training and support; both onsite and via remote conferencing. This involves work nights and weekends, approximately nine months of the year, when the APS has run cycles and is open for data acquisition. During these months, the staff scientist will rotate assignments with other staff members to provide support 24 hours a day, seven days a week.

•       Test, modify or develop crystallographic software.

•       Test and debug new beamline software and hardware. Evaluate beamline performance to produce optimum data. Contribute to the development of beamline troubleshooting procedures.

•       Use knowledge of synchrotron beamline optics and experiment-specific topics to develop data collection and structure determination procedures.

•       Take part in development of real time data analysis software for the beamline data acquisition software RAPD.

•       Collect data on macromolecular crystals for phase determination, model building and refinement.

•      Participate in cooperative research in which the staff scientist's expertise is combined with that of members of the NE-CAT consortium institutions or general users to improve the processes of protein purification, crystallization, and determination of macromolecular structures.

•       Publish results and help prepare presentations and documentation to disseminate information about advances to the macromolecular crystallography community.

Related Duties:

•       Provide support of sample automounter development.

•       Provide advice and consultation to users and technical support staff.

•       Assist in preparation of research grant proposals and annual reports.

•       Attend and participate in seminars and scientific meetings.

•       Recommend equipment and supplies necessary to further research associated with the mission of the facility.

•       Help supervise technicians who will develop user safety procedures, calibration procedures, data collection procedures, and both on-line and standard documentation.

•       Any other beamline/facility related duties assigned by the supervisors.

Qualifications:

•       Doctorate in Chemistry, Biochemistry, Physics, Biophysics, or a related field.

•       At least three years doctoral or post-doctoral experience involving macromolecular crystallography.

•       An extensive record of publications of research in the scientific literature.

•       Experience with synchrotron X-ray data collection and experience with operating synchrotron beamlines is a plus.

For more information about NE-CAT, please see our website: https://necat.chem.cornell.edu

This is a 12-month benefits eligible full-time (100%FTE) appointment term which is renewable depending on funding and performance.

Salary: commensurate with experience

Start: August 1,2019

Interested candidates should submit a cover letter, curriculum vitae, copies of relevant publications, and contact information for three references electronically to Academic Jobs Online at https://academicjobsonline.org/ajo/jobs/14009. Applications will be reviewed as they are received and will be accepted until the position is filled. Please direct questions to Frank Murphy, NE-CAT Associate Director (fmurphy@anl.gov).

Cornell is an equal opportunity, affirmative action educator and employer.


[Post Date: July 9, 2019]


Associate Scientist/Scientist Position in Antibody Engineering

View the Job Posting Here

job posting image

Description:

We are seeking a fresh PhD graduate or postdoc with a structural or biophysics background to join our group. This is an excellent opportunity for anyone looking to break into the extremely desirable field of antibody engineering for immuno-oncology.

The position entails the design, cloning, purification and in vitro testing of multispecific antibody type molecules. The training involves in silico design (including MD analysis) molecular biology, HEK and CHO expression, Antibody purification and biophysical analysis including SEC, MALS, DLS, RP, Mass Spec, Kinetic analysis (Octet) Binning, Humanization, and in vitro validation including FACs analysis, immune cell activation and cancer cell line killing assays.

Although experience is not necessary, we expect interview candidates to have researched the above topics thoroughly and to express and explicit interest in the field of protein engineering for immuno-oncology.


[Post Date: July 8, 2019]


Postdoctoral position on structure of amyloid fibrils (cryo-EM/X-ray)

View the Job Posting Here

job posting image

Description:

Postdoctoral Position at the Institute of Protein Biochemistry, Ulm University (Germany), Group Prof. Dr. M. Fändrich

The Institute of Protein Biochemistry (https://www.uni-ulm.de/nawi/nawi-pbc.html) investigates the molecular basis of amyloid diseases, such as Alzheimer's disease and systemic amyloidosis. We use a broad range of techniques from protein biochemistry, structural biology (in particular cryo-EM) to cell biology. Our strong ties to several medical institutions enable us to uniquely link structural biology with patient and animal samples. We seek for new postdoctoral co-workers with a strong background in cryo-EM or X-ray crystallography to strengthen our cryo-EM projects on amyloid fibril structures. Projects may involve protein purification and sample preparation, cryo-EM imaging, single particle reconstruction, structural modelling and the combination of structural and biological/medical data.

Recent references:

Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids.

Liberta F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC, Grigorieff N, Fändrich M, Schmidt M.

Nature Comm. 10, 1104 (2019)

Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis.

Radamaker, L, Lin Y-H, Annamalai K, Huhn S, Hegenbart U, Schönland SO, Fritz G, Schmidt M, Fändrich M.

Nature Comm. 10, 1103 (2019)

If you are interested, please contact us under bewerbung-pbc(at)uni-ulm.de. Incoming mails will be viewed till August 2nd 2019. Position will be filled as soon as possible.


[Post Date: July 4, 2019]


Postdoctoral position in structural biology, Ghent University and VIB, Belgium

View the Job Posting Here

job posting image

Description:

A funded postdoctoral position in structural biology (up to 3 years) is available in the Unit for Structural Biology at the VIB-UGent Center for Inflammation Research (IRC) in Ghent, Belgium. Our group employs an integrative structural biology approach in conjunction with molecular interaction studies and cellular interrogation of the systems under study to elucidate the structural and mechanistic principles underlying the assembly, activation and pathophysiology of macromolecular complexes pivotal to inflammation, immunity, and cancer.

Recent work by our group includes:

https://doi.org/10.1038/s41586-019-1095-5 (Nature, 2019)

https://doi.org/10.1126/science.aaw4295 (Science, 2019)

https://doi.org/10.1016/j.immuni.2017.12.008 (Immunity, 2018)

https://doi.org/10.1038/ncomms14937 (Nature Communications, 2017)

Candidate profile

  • Doctoral degree in the field of Biochemistry, Biotechnology, Biophysics
  • Keen interest in structural biology
  • Broad practical experience in molecular biology, protein biochemistry, and production and purification of recombinant proteins and complexes thereof towards structural and biophysical studies
  • Research experience in one or several of the following methodological approaches in structural biology is an asset:

o             Single-particle Electron Microscopy

o             Macromolecular X-ray Crystallography

o             Small-angle X-ray Scattering

  • Experience in biophysical methods for the study of protein-protein and protein-ligand interactions (e.g. Isothermal Titration Calorimetry, Surface Plasmon Resonance, Biolayer Interferometry, Multi-Angle Laser Light Scattering)
  • Publication record in international journals subjected to peer-review
  • Collaborative spirit
  • Interest in translational aspects of fundamental research

Our research department (https://www.irc.ugent.be), the VIB (www.vib.be), and Ghent University (https://www.ugent.be/en) are all internationally recognized centers for research and scholarship. The VIB Center for Inflammation Research offers a very stimulating environment to conduct high-level basic and translational biomedical research supported by an international research community.

This position is available immediately. Candidates are asked to apply online via https://jobso.id/bys2

Please include a detailed CV with list of publications, a letter of motivation, and the names of two references.

The deadline for application is August, 1st.

Informal inquiries to kenneth.verstraete@irc.vib-ugent.be are welcome.


[Post Date: July 3, 2019]


Staff Scientist EMBL Hamburg

View the Job Posting Here

job posting image

Description:

EMBL Hamburg is currently advertising for a Staff Scientist position in the research group of Matthias Wilmanns.

Deadline for application is 8th August 20

For informal enquiries, please contact Matthias Wilmanns directly at : matthias.wilmanns@embl-hamburg.de

Further information regarding the position and how to apply can be found at the link above.


[Post Date: July 3, 2019]


Postdoctoral positions available on protein misfolding in Atlanta, GA

View the Job Posting Here

job posting image

Description:

The Lieberman lab in the School of Chemistry & Biochemistry at Georgia Institute of Technology in Atlanta, GA invites applications for Postdoctoral Fellows.

Our research projects focus on molecular aspects of protein misfolding in one of two systems related to human disease. Our interdisciplinary lab combines biochemical, biophysical, and cell biology methods with structural biology approaches (X-ray crystallography, small angle X-ray or neutron scattering, NMR, cryoEM). We seek to better understand what differentiates diseased proteins from their wild-type counterparts, and use this information to develop new diagnostics and therapies. More information is available on our website http://ww2.chemistry.gatech.edu/lieberman/.

Candidates must have a Ph.D. degree in life sciences, chemistry, biological physics, and related fields. Hands-on expertise and publication record in any (but not all!) of the following areas is also required: protein biochemistry (e.g. enzyme, binding assays, membrane proteins), biophysics (e.g. spectroscopy, kinetics of aggregation, AFM imaging), cell biology (e.g. mammalian cell culture, Western blotting), or structural biology (e.g. crystallography, SAXS, SEC-MALS, NMR). Experience with molecular biology, protein expression and purification are also desirable.

To be considered for a position, please send an email to Raquel Lieberman, Raquel.lieberman@chemistry.gatech.edu. Include your curriculum vitae as well as a short cover letter describing research experience, and why you think you would be a good fit for our research team.

Georgia Institute of Technology is a top public university in the USA located in the urban heart of Atlanta, GA. Georgia Tech is committed to recruiting, developing, retaining, and engaging a diverse cadre of students, faculty, and staff with a wide variety of backgrounds, perspectives, interests, and talents.


[Post Date: July 2, 2019]


Postdoctoral fellowship available for studies of adhesion in bacterial conjugation

View the Job Posting Here

job posting image

Description:

A postdoctoral fellowship is available in the Ronnie Berntsson group at Umeå University, Sweden (https://www.biostruct.umu.se/principal-investigators/ronnie-berntsson/).

Our lab studies bacterial conjugation via Type 4 Secretion Systems, with a special focus on gram-positive bacteria. The open position revolves around understanding the structure and function of the adhesion proteins that facilitate the cellular mating pair formation.

Our lab is part of the Integrated Structural Biology at Umeå University and is fully equipped for biochemistry and structural biology, with on site access to local facilities in x-ray crystallography (mosquito, RockImager, formulator etc), electron microscopy (Titan Krios, Talos 120 kV, Scios Dual beam for FIB-Milling).

We would like to recruit a postdoc with prior experience in protein expression/purification, biochemistry and structure determination.

For full detail regarding the position and how to apply, please see the link above.


[Post Date: July 2, 2019]


Postdoc Position Structural Biology of Ion Channels

View the Job Posting Here

job posting image

Description:

A post-doctoral position is available at the Laboratory of Structural Neurobiology, KU Leuven Belgium (http://www.xtal.be). The research in our laboratory is aimed at understanding the molecular mechanism of ligand-gated ion channels. Our method relies on X-ray crystallography and cryo-EM in combination with electrophysiological recordings and fluorescence spectroscopy. Our laboratory hosts an integrated macromolecular crystallization facility with a Mosquito crystallization robot and two RockImagers. Current structural targets include the family of pentameric ligand-gated ion channels (Cys-loop receptors), TRP channels and CNG channels.

We would like to recruit a post-doc with prior experience in expression, purification and crystallization of membrane proteins. Prior experience with X-ray crystallography or cryo-EM is considered a major advantage.

The successful candidate:

- easily communicates in an open verbal manner and has a team player spirit

- has an ambitious work ethic

- critically contributes to writing of manuscripts and grant proposals

- makes efforts to obtain independent funding

- meets intermediate deadlines and brings projects to a successful end

- fuels internal discussions of recent publications in the field

- sets an example to younger PhD students in the lab

- identifies directions for future scientific research

The position is open immediately and applications will be accepted until the position is filled. Applicants are requested to submit a CV with publication list and two references. E-mail to chris.ulens@kuleuven.be

Selected lab publications:

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor. Spurny R, Debaveye S, Farinha A, Veys K, Vos AM, Gossas T, Atack J, Bertrand S, Bertrand D, Danielson UH, Tresadern G, Ulens C.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2543-52.

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, Ulens C. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3028-34.

A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors. Brams M, Pandya A, Kuzmin D, van Elk R, Krijnen L, Yakel JL, Tsetlin V, Smit AB, Ulens C.

PLoS Biol. 2011 Mar;9(3):e1001034.


[Post Date: July 1, 2019]


Structural Biologist/biochemist position at Broad institute of MIT and Harvard

View the Job Posting Here

job posting image

Description:

The Zhang Lab (zhanglab.bio) focuses on discovering and harnessing novel biological systems for development as molecular tools. In addition to our work with CRISPR-Cas systems, we have recently identified a number of additional exciting biological systems and we are working to understand their function and mechanisms. We are looking to recruit a sharp, experienced, creative Structural Biologist to lead projects aimed at mechanistically characterizing these novel systems and rationally engineering them for use as biotechnologies.

The candidate will pursue his/her own structural biology projects within the group, collaborating with existing lab members or new hires as needed to advance the projects. Candidate must have strong background in biochemistry and structural biology research with successful demonstration of the ability to solve protein structures, and of particular interest, protein assemblies including RNA and DNA molecules. The ideal candidate will also possess superior experimental planning and execution skills, an open mind, curiosity about molecular mechanisms, and a strong desire to tinker.

The Zhang lab is a member of the Broad Institute of MIT and Harvard and McGovern Institute at MIT, and a part of the greater Boston life-science community including MIT and Harvard with ready access to structural biology resources, beamlines and Krios Cryo-TEM. Our lab is a fun, vibrant, fast-paced, result-driven, and collaborative environment with state-of-the-art research facilities and support from NIH, HHMI, and various foundations and philanthropies. We are a unique multidisciplinary lab working to bridge fundamental biology and development of biotechnology.

The Broad Institute of MIT and Harvard offers an outstanding place to work. The workplace culture is diverse, dynamic, progressive, and supports a healthy work-life balance. To support this mission, we strive for a workplace culture that supports diversity, intellectual curiosity, flexibility, and integrity. Broad employees receive a generous benefits package (including a highly competitive salary, dental, vision and health insurance, retirement plan, and additional benefits) and a range of possibilities for career advancement. Details on our benefits package can be found here - https://www.broadinstitute.org/benefits/benefits-working-broad

PRINCIPAL DUTIES AND RESPONSIBILITIES:

·       Develop, lead, and execute research projects

·       Stay current on the field and think deeply about creative new ways to have an impact

·       Contribute to the lab through teamwork and discussion

·       Help to train, supervise, and mentor junior staff as needed

MINIMUM QUALIFICATIONS:

·       PhD in relevant field (structural biology, biochemistry, biophysics, molecular biology)

·       Extensive experience with biochemical, structural, and/or biophysical experimental techniques

·       Demonstrated scientific contributions to the field

·       Proven ability to efficiently and effectively solve problems

Contact: zhangoffice@broadinstitute.org


[Post Date: July 1, 2019]


Synchrotron Macromolecular Crystallographer

View the Job Posting Here

Description:

LOCATION: IMCA-CAT at the Advanced Photon Source (near Chicago, IL)

The Industrial Macromolecular Crystallography Association - Collaborative Access Team (IMCA-CAT) and the Hauptman-Woodward Medical Research Institute (HWI) seek an inventive macromolecular crystallographer to join the IMCA-CAT team in accelerating pharmaceutical drug discovery through synchrotron-based structural biology research. As an employee of HWI, you will be based at the center of the team’s operations at the Advanced Photon Source (APS), Argonne National Laboratory, near Chicago, IL. This is an ideal position for a motivated scientist who is passionate about delivering strategic value, developing new technologies, and working in a high- powered, collaborative environment.

DESCRIPTION:

This is an exciting time to join IMCA-CAT. Underway this summer is the first of a two-phase upgrade that will significantly increase throughput and establish a strong foundation upon which to build capacity. The second phase upgrade, currently in design, will profoundly increase capacity and dramatically expand capability for challenging research projects.

The successful candidate will be an integral part of these upgrade activities while maintaining flow of diffraction data for pharmaceutical research projects. The candidate will work closely with IMCA-CAT colleagues in an inclusive and respectful environment, and is expected to take initiative and contribute to the team effort.

On any given day, you will do one or all of these things:

               • Contribute to drug discovery research efforts using a growing portfolio of synchrotron sources.

               • Enhance the structural biology programs for pharmaceutical structure-based drug design.

               • Provide experiment support for scientists from the structural biology community who conduct research using the IMCA-CAT synchrotron beamlines.

               • Ensure beamline instrumentation is operational and produces data of the highest quality.

               • Expand the experiment envelope of the beamline.

               • Establish efficient protocols for accelerating data acquisition while enhancing data security.

               • Develop automated methods for acquiring quality data from challenging samples.

               • Participate in highly collaborative working groups.

               • Engage in the technical development of new strategies for ultra-high throughput.

               • Collaborate with staff on strategically-aligned research and development projects.

               • Communicate with researchers and present at meetings.

               • Conduct independent and/or collaborative research.

DESIRED SKILLS and EXPERIENCE:

               • PhD in a relevant field.

               • Expertise in macromolecular crystallography.

               • Outstanding experimental skills.

               • Considerable mechanical skills.

               • Highly collaborative and team-oriented approach to conducting work and solving problems.

               • Excellent written and oral communication skills.

               • Deeply proactive approach to meeting and exceeding goals.

               • Ability to meet requirements for site access to Argonne National Laboratory.

TO APPLY:

Send an introductory email, cv, and contact information for three references to Lisa Keefe, IMCA-CAT Director and HWI Vice President of Advancing Therapeutics, at keefe@imca-cat.org

HWI is an equal opportunity employer.


[Post Date: July 1, 2019]


Postdoc Structural Bbiology/Drug Discovery/Design

View the Job Posting Here

job posting image

Description:

We wish to appoint a talented and ambitious Research Associate to develop novel approaches to targeting malaria and tuberculosis. Drug resistance is becoming increasingly problematic in malaria and TB, two of the most-deadly diseases in human history. The WHO estimates that there were over half a million cases of drug-resistant TB in 2017. This exciting pilot project is funded by the Bill&Melinda Gates Foundation for 13 months to investigate the feasibility of developing inhibitors of DNA replication in these globally important pathogens.

You will have a Ph.D. (or be close to completion) in a relevant life-sciences subject and experience in X-ray crystallography, structure refinement, protein purification and executing crystallization trials. The successful applicant will conduct world-class research in structure-based drug design to develop inhibitors of microbial flap endonucleases (FENs). FEN enzymes are involved in cellular DNA synthesis and genome damage repair. We have shown that a member of this important class of enzymes contains a novel DNA-binding motif, the helical arch (Al Malki et al, Direct observation of DNA threading in flap endonuclease complexes. 2016, Nature Structural and Molecular Biology, 23, 640-646).

You will facilitate production, crystallization and X-ray crystal structure determination of FEN enzymes and their complexes with inhibitors. You will work closely with a second postdoctoral Research Associate carrying out enzyme production and inhibitor assays as well as with chemo- informatics experts. We welcome highly dedicated and enthusiastic candidates with the ability to develop their scientific skills in the direction of rational drug design.

You will join a multi-disciplinary team spanning two research groups: The Sayers lab is based within the Dept. of Infection, Immunity and Cardiovascular Disease; and the Baker group is housed within the Dept. of Molecular Biology and Biotechnology. This vibrant team works on FEN mechanism and applications in biotechnology as well as inhibitor discovery in other target organisms. We use site- directed mutagenesis, crystallography and kinetic approaches to determine how these complicated enzymes function in order to design inhibitors in conjunction with virtual and physical screening. The groups are housed within well-equipped laboratories with access to excellent core facilities with state-of-the-art equipment for e.g. biological mass spectrometry, nucleic acid sequencing, X-ray crystallography, liquid handling for high throughput screening, crystallization robotics, plus a range of microscopy facilities, etc. The Sayers group hosts a Marie Curie Individual Fellow and PhD students working on homologous FENs derived from bacteria and viruses.

 


[Post Date: June 27, 2019]


Research Associate position in Structure-based Antibody Engineering Group

View the Job Posting Here

job posting image

Description:

We have an opportunity for a highly motivated Research Associate/Senior Research Associate to join Ohana Biosciences.

At Ohana Biosciences, we are pioneering a new frontier in reproductive medicine. The successful candidate will be responsible for expression, purification, characterization, and crystallization of antibody:antigen complexes for structure determination. In addition, the candidate will be responsible for the biophysical characterization of antibody targets using techniques such as SPR/BLI, DLS, and DSF. The candidate will evaluate cutting-edge new platform technology and be on the forefront of antibody discovery and engineering. The candidate will be expected to work on a variety of protein engineering projects to optimize and generate antibody leads for Ohana’s therapeutic and fertility programs.

Qualifications:

  • Minimum Bachelor’s degree in a relevant scientific discipline (biochemistry, biophysics, molecular and cell biology, or similar field)
  • Experience with bacteria and/or mammalian culture
  • Previous use of manual and automated purification instrumentation
  • Proficiency in biochemical techniques such as SDS-PAGE, Western blot, and ELISA
  • Experience with binding techniques (SPR, Octet etc.), protein stability assays, display technologies, or crystallography Eagerness to learn new techniques, and comfort asking questions and seeking clarity
  • Collaborative attitude with a strong work ethic and self-motivation


[Post Date: June 25, 2019]


Postdoc Rice Lab University of Chicago

View the Job Posting Here

job posting image

Description:

A post-doctoral position is open in the Rice lab at the University of Chicago (https://voices.uchicago.edu/phoebericelab/).  The primary project is to figure out, through biochemistry and structural biology, the mechanisms of self-loading helicases encoded by medically nasty staphylococcal mobile genetic elements.  The lab employs a variety of approaches from cryo-EM and crystallography through biochemistry and microbiology, all aimed at understanding mobile DNA elements at the molecular level.  A variety of additional project opportunities are also available. 

The Advanced Electron Microscopy Facility at the University of Chicago currently houses a 200 KV Talos F200C microscope with side-entry holders and a Vitrobot plunge freezer for cryo screening, a 120 KV Spirit microscope for negative-staining, and a 300 KV Tecnai F30 for plastic tomography.

The University has made > 10M dollars in investments to upgrade the facility with a state-of-the-art 300 KV Titan Krios microscope equipped with a K3 direct detection camera and Volta phase plate, which will be fully installed by the end of 2019. Additional upgrades include a Aquilos cryo FIB-SEM Leica, Apreo volume scope and Leica EM GP2 cryo-plunge.

The Advanced Photon Source’s fantastic x-ray beamlines are also a short drive away.

Top candidates will have a PhD (or be about to receive one) and experience in cryo-EM and biochemistry.  To apply, please send your CV, with names and contact information for 3 references, to me by e-mail: PRice@uchicago.edu

Be the one who turns this science fiction figure into reality!

The University of Chicago is an Affirmative Action/Equal Opportunity/Disabled/Veterans Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national or ethnic origin, age, status as an individual with a disability, protected veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination at http://www.uchicago.edu/about/non_discrimination_statement/. Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-0287 or email ACOppAdministrator@uchicago.edu with their request.  


[Post Date: June 24, 2019]


Structural biologist to join the Structural Motility team at the Curie Institute Paris, France

View the Job Posting Here

job posting image

Description:

Job opening for a structural biologist to join the Structural Motility team at the Curie Institute Paris, France.

We are looking for a post-doctoral fellow to join the team Structural Motility at the Curie Institute (Paris Center) directed by Anne Houdusse.

The Structural Motility team at the Institut Curie has gathered important structural insights on how force generated by molecular motors can power cellular processes in human health and disease. We combine chemical biology and optogenetics approaches to test these insights and understand how molecular motors produce force, how their activity is regulated and how they are recruited to their cellular targets. Many of these motors are also involved in human pathologies and they are thus good targets for new therapies which we are helping to develop.

The post-doctoral fellow we will hire will coordinate these approaches and perform research to gain more structural insights concerning a molecular motor that is a target against cancer. We are looking for an expert in biochemical, crystallogenesis and structural determination studies. The post-doctoral fellow will also gain expertise in functional and cellular studies.

A solid experience in crystallization and X-ray structural determination is required. Experience in the production and purification of recombinant proteins is a plus but we are ready to train a dynamic and motivated candidate.

If you are interested, please send a CV and a letter of motivation as well as letters of recommendation of your previous employers.

Contact : Anne Houdusse (anne.houdusse@curie.fr)


[Post Date: June 24, 2019]


Post-doctoral Position at IGBMC, Strasbourg, France

View the Job Posting Here

job posting image

Description:

A post-doctoral position is available to study the mechanistic role of transcription factors in hematopoiesis and leukemogenesis at the structural level in the laboratory of Susan Chan and Philippe Kastner, at the Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg, France in collaboration with the Department of Integrated Structural Biology.

The IGBMC is a component institute of the CERBM (European Centre for Research in Biology and Medicine) and one of the leading centres in biomedical research in France and Europe. It is well equipped for molecular, cellular and structural biology, as well as genetic and animal experimentation. The department of Integrated Structural Biology is located in the new Centre for Integrative Biology (CBI), which is part of the European distributed Structural Biology Infrastructure (Instruct) and is well equipped for structural investigations using state-of-the-art X-ray diffraction equipment and cryo electron microscopes (Titan Krios and Polara microscopes).

The project will aim at unveiling the architecture of transcriptional complexes with a multipronged structural and functional approach. This project will require the production, characterization and structural investigation of transcription factor-associated complexes. To achieve this goal, a range of techniques encompassing molecular biology, biochemistry and biophysical characterization, will be employed. The Postdoctoral Research fellow will benefit from access to the Structural Biology and Genomics platform at IGBMC (cloning, purification, crystallization).

Candidates must have a Ph.D. degree, a keen interest in structural biology, and should enjoy working as part of an interdisciplinary team. They should have a background in at least one of the following areas: molecular biology; biochemistry, in particular protein expression and purification; biophysics; X-ray crystallography; cryo electron microscopy. We welcome highly qualified and motivated individuals, with a recently obtained PhD in structural biology and first author publications in peer-reviewed international journals, who can work easily in a multi-lab consortium. This position is available immediately and is funded for two years.

Please send a detailed CV with list of publications, a letter of motivation, and the names of three references to Susan Chan and Philippe Kastner scpk@igbmc.fr.


[Post Date: June 20, 2019]


Project Manager in Crystallography

View the Job Posting Here

job posting image

Description:

NovAliX is a company specialized in external research (medicinal chemistry, protein crystallography, process R&D). NovAliX offers a complete range of services in the field of research and development of small molecules. The company has a team of 100 scientists.

The position is permanent and based in Saclay, Essonne (South of Paris-France).

You will join our 7-membered structural biology insourced team located on the Synchrotron SOLEIL to manage projects for our client in the field of structural biology. Your work will consist in:

-     Conducting crystallographic projects from bibliographic work to structure determination, as well as project follow-up, clients reporting, drafting procedures and/or reports.

-     Managing and supervising a team of research associates.

You will be in charge of protein production and purification from different expression systems, X-ray diffraction data collection & processing, structure determination of proteins of interest and of protein-ligand complexes.

You should have a PhD in crystallography with ca. 4-6 years of experience in modern Crystallography techniques (preferentially experienced in the life science industry) during which you have deepened and widened your practical and theoretical knowledge in the field of construct design, protein biochemistry and crystallography. A good knowledge of software packages employed in protein crystallography is a must. Additional experience in molecular biology and/or insect cells culture, membrane proteins and/or characterization of protein/ligand complexes would be an asset.

We are seeking a person who speaks fluently English and French, who is passionate about structural biology and who has a keen sense of responsibility as well as being a committed team player. The candidate will have a rigorous and organized attitude to work with excellent supervisory and reporting skills.

Please send your questions/application (CV, research statement and references) by email to:

career@novalix.com


[Post Date: June 20, 2019]


Postdoctoral Structural Biologist Position at Vanderbilt University Medical Center, Department of Biochemistry

View the Job Posting Here

job posting image

Description:

A postdoc position is available in the laboratory of Dr. Stephen Fesik (https://lab.vanderbilt.edu/fesik-lab/) for a structural biologist with experience in protein NMR or X-ray crystallography.  Responsibilities will include protein expression/purification, conducting fragment screens using NMR, and all aspects of x-ray crystallography, including preparation of protein-inhibitor complexes, crystallization, home/synchrotron data collection, and structure determination. Experience in cloning, site-directed mutagenesis, and the use of robots are highly preferred.  The ideal candidate should be self-motivated and be able to communicate effectively in a highly collaborative environment.  


[Post Date: June 19, 2019]


Biochemical Information & Annotation Specialist

View the Job Posting Here

job posting image

Description:

Curate, validate, and standardize macromolecular structures from the PDB community. Participate in exciting projects with significant impact on the scientific community.

Data archives are critical to research and education. They provide safe and secure storage of valuable scientific data, and ensure that information is freely available to the world. Data curation is critical for these resources. In the case of PDB, data are carefully reviewed and annotated by wwPDB curators before public release. Expert curation of data coming into PDB is critical for ensuring findability, accessibility, interoperability, and reusability (FAIR). Biocurators communicate daily with members of the deposition community, and annotate, publicly release, and update entries in the PDB archive.

The RCSB PDB at Rutgers University in Piscataway, NJ has two openings for a Biochemical Information & Annotation Specialist (Biocurator) to curate, validate, and standardize macromolecular structures for distribution in the PDB Core Archive.


This position offers the opportunity to participate in exciting projects with significant impact on the scientific community. The position is an academic position with state benefit. The salary is compatible with faculty level.

Knowledge and Skills:

  • PhD in Biological chemistry or chemistry is required
  • Background in 3DEM or crystallography has strong advantage
  • Experience with small molecules such as organometallic complexes is preferred
  • Knowledge of Linux computer systems and biological databases is preferred

The successful candidate should be self-motivated, pay close attention to detail, possess strong interpersonal, communication, and writing skills, with the ability to handle multiple projects, shifting priorities, while meeting deadlines. This academic position has state benefits and a faculty-level salary.


[Post Date: June 19, 2019]


Scientist, X-Ray Crystallography - La Jolla, California

View the Job Posting Here

job posting image

Description:

We have exciting opportunities for talented structural biologists to join our team in La Jolla, CA at Janssen Research and Development. Please follow the link for application information.


[Post Date: June 13, 2019]