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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.


Postdoc Positions Stark Neuroscience Research Institute Indiana University School of Medicine

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Description:

The Hoang Lab at the Stark Neuroscience Research Institute Indiana University School of Medicine has a couple of Postdoc positions available immediately to study the structures and functions of proteins associated with neurodegenerative diseases.  The projects utilize cryo-EM and X-ray crystallography along with a battery of other biophysical and biochemical methods.  As such, they might be good opportunities for crystallographers looking to learn cryo-EM or microscopists wishing to learn X-ray crystallography (however, experiences with these methods are not necessary to apply). These positions are supported by a new 5-year NIH grant.  Please email me directly (qqhoang@iu.edu) if you are interested in learning more about these positions.


[Post Date: August 16, 2022]


Postdoctoral position at the VIB-VUB Center for Structural Biology

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At the VIB-VUB Center for Structural Biology (Vrije Universiteit Brussel / VIB – Brussels - Belgium), we are looking for a highly qualified and motivated postdoctoral researcher with a strong background in Cryo-EM and/or X-ray crystallography, biochemistry and biophysics, and interested in biochemical and structural studies on bacterial persistence pathways.

Project description: Due to the development of resistance to antibiotics, bacterial infections are becoming more life-threatening every year. In addition to resistance, bacterial persistence offers an important means to avoid clearance of infections. Persisters are formed by phenotypic switching to an antibiotic-tolerant state, rendering a small subset of cells within an isogenic population capable of surviving antibiotic treatment. Within this ongoing research project we want to gain more insight into the mechanisms of persistence by unravelling the associated molecular pathways down to atomic resolution (e.g. Verstraeten et al. Mol. Cell 2015; Gkekas et al. J. Biol. Chem. 2017; Verstraeten et al. Mol. Microbiol. 2019). The project is part of an interdisciplinary Excellence of Science program in collaboration with the teams of Jan Michiels, Régis Hallez, Françoise Van Bambeke, Steven Ballet and Jörg Vogel. Within this consortium you will use single particle cryo-EM and X-ray crystallography, in combination with biophysical methods and enzyme kinetics, to gain insight in the role of important persistence proteins and their interactions. This information will subsequently be used to intervene with these proteins and processes to devise new potential therapeutic strategies.

For more information about the Versées lab see https://verseeslab.sites.vib.be/en

Required skills and experience:

  • PhD in Biochemistry, Molecular Biology, Bio-engineering or equivalent
  • Strong background in protein expression, purification and characterization
  • Experience in Cryo-EM and/or X-ray crystallography is mandatory
  • Proficient in written and spoken English
  • Strong organizational and interpersonal skills

Contact: Please send applications (including CV, research experience, and at least two names and contact information for references) to: Wim.Versees@vub.be.

About CSB: The VIB-VUB Center for Structural Biology focusses on the structure and dynamics of macromolecular complexes in health and disease. Our multidisciplinary team of about 100 researchers is housed in new laboratory facilities and combines extensive expertise in structural biology (state of the art in-house cryo-EM, X-ray crystallography, NMR, SAXS, and atomic force microscopy), biophysics, enzymology and molecular biology.


[Post Date: August 7, 2022]


Staff Scientist opening at UT Health San Antonio

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Description:

The University of Texas Health Science Center at San Antonio is seeking a Staff Scientist to support the protein production capabilities of its Structural Biology Core Facilities (SBC). The Protein Production Facility has infrastructure for recombinant protein production in bacterial, insect, and mammalian expression systems and is fully equipped for protein purification and characterization. The Protein Production Facility is closely integrated with the X-ray, NMR, and cryo-EM facilities of the SBC and will provide the successful candidate with opportunities to develop experience and skills in these techniques.

Interested candidates should email a curriculum vitae, a list of three references and a cover letter addressed to Dr. Shaun K. Olsen at olsens@uthscsa.edu. Review of applications will begin immediately upon receipt and will continue until the position is filled.


[Post Date: August 5, 2022]


Job opening at ModeX

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Description:

ModeX Therapeutics is seeking a highly skilled and motivated scientist to support biologics production, characterization, and optimization for developing innovative biotherapeutics. This is an exciting opportunity to be part of a cross-functional team and contribute to the development of next-generation biological therapeutics in a fast-paced, rapidly growing biotech company with a bold vision. 

Company

ModeX Therapeutics, a subsidiary of OPKO Health, is a biotech based in Massachusetts dedicated to the concept of modulating multiple disease targets with innovative multi-targeting strategies. It was founded by Dr. Elias Zerhouni and Dr. Gary J. Nabel in 2020 with a team of scientists with proven track record from early research to clinical development, regulatory approvals, and commercialization. ModeX is pursuing the development of novel immune-oncology therapeutics for cancers and biotherapeutics against infectious disease.

Major responsibilities

  • Interact closely and be part of interdisciplinary biologics research teams to drive the discovery of innovative therapeutic antibodies and the optimization of their biochemical and biophysical properties.
  • Contribute to ModeX’s multi-targeting strategy through structure-based antibody design, production, and characterization platforms.
  • Develop a high-throughput antibody expression and purification platform and lead the effort in producing high-quality multispecific antibodies for developability assessment and PK/PD studies.
  • Perform biochemical and biophysical characterization of diverse biologics molecules, including multi-specifics, fusion proteins, and non-viral particle to support lead candidate selection, focusing on antibody’s biophysical properties including chemical stability, solubility, polyspecificity and polyreactivity.
  • Interpret results and present/communicate with cross-functional colleagues for successful execution and completion of projects.
  • Stay scientifically current and contribute to the implementation of new technology and instrumentation.
  • Ensure effective and timely documentation in electronic laboratory notebooks.

Qualifications

  • PhD or MS in biochemistry, structure biology, biomedical engineering, or other life science disciplines
  • Minimum of 3 years (PhD)/ 6 years (MS) of relevant experiences
  • Knowledge in antibody structure and the development of antibody-based biotherapeutics is preferred.
  • Skilled in protein expression in mammalian cells and protein purification using various chromatography methods and instruments such as AKTA FPLC.
  • Experience with protein analytic techniques such as HPLC/UPLC, cIEF/CE-SDS, SLS/DLS, and BLI/SPR based protein-protein interaction characterization is a plus.
  • Excellent written and oral communication, organization, and data analysis skills.  Outstanding troubleshooting and problem-solving skills.
  • Highly adaptable to a fast-paced work environment and capable to work both independently and collaboratively within project teams.

To apply, please send cover letter and CV to hao.chen@Modextx.com and careers@ModeXTX.com


[Post Date: August 5, 2022]


New Research Opportunities

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Description:

Several research positions are available for joining a dedicated team of scientists working at the interface of chemistry and biology to generate new classes of tool compounds and leads for cancer drug discovery. The positions are in the Dar laboratory at Mount Sinai in New York City. The lab is located in the Hess Center for Science and Medicine, which provides a rich environment for scientific interactions, collaborations, and state of the art facilities. An extensive program of seminars, symposia and other organized meetings on campus focused on a large array of topics in cancer, chemical biology, cardiovascular research, and neuroscience provides broad exposure to biology and medicine. If interested, please respond with your CV, a description of past research experiences, and references to arvin.dar@mssm.edu

For a recent example of work from the lab, please see: https://www.nature.com/articles/s41586-020-2760-4

Additional information on the lab can be found at: http://www.mountsinai.org/profiles/arvin-dar


[Post Date: August 1, 2022]


Postdoctoral Scientist – Protein Biochemistry & Structural Biology - Huber Group

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Description:

Target Discovery Institute, NDM Research Building, Roosevelt Drive, Headington, Oxford, OX3 7FZ

Contact Person : Kaitlin Beazley Vacancy ID : 158581
Contact Phone : 01865 287734 Closing Date & Time : 22-Aug-2022 12:00
Pay Scale : STANDARD GRADE 7 Contact Email : recruitment@ndm.ox.ac.uk
Salary (£) : Grade 7: Salary in range £33,309 - £36,382 per annum


[Post Date: August 1, 2022]


Scientist, X-ray Crystallography - San Diego, CA

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Job Description

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Scientist, X-ray Crystallography, located in La Jolla, CA!

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The Discovery Technologies and Molecular Pharmacology group is a dynamic, diverse and critical part of the Discovery Sciences organization in Janssen R&D. We are committed to the discovery and characterization of high-quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Areas. This mission requires deep scientific expertise across broad subject areas including chemistry, cellular and molecular pharmacology, enzymology, screening, protein science, and structural biology coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding and motivated individual to join our team as Scientist, X-ray Crystallography.

As the Scientist you will:

  • Be an active member of drug discovery teams, working closely with computational and medicinal chemists on structure-based drug design approaches for small molecule agent optimization.
  • Be responsible for crystallization of protein-small molecule complexes, determination of high-resolution structures by X-ray crystallography and communicating these results to the project team.
  • Work closely with protein scientists, biophysicists, protein NMR and cryo-EM scientists as part of an integrated structural biology effort.
  • Contribute to multidisciplinary Fragment-Based Lead Discovery (FBLD) efforts.
  • Contribute to enhance the structural biology scientific expertise of the group by publishing high-impact research papers, and presenting at scientific conferences, internalizing impactful technologies and platforms, and establishing academic collaborations.
  • Mentor lab scientists and contribute to the strategic planning of the Structural Biology group.

Qualifications

  • BS degree with at least 12 years of experience, OR MS degree with at least 9 years of experience, OR a Ph.D. or equivalent and postdoctoral experience in structural biology (X-ray crystallography, biophysics, protein engineering) or related field is required
  • Expertise with crystallography software packages (Phenix/CCP4/PyMol/Moe) in a mixed Linux/Windows computational environment is required
  • Scientific expertise in structural biology, with strong experience in both protein crystallization and structure determination is required
  • Strong record of external publications and presentations is required
  • Outstanding written and oral communication skills are required
  • Experience in Structure-Guided Drug Design utilizing X-ray crystallography is preferred
  • Research experience in cryo-electron microscopy (Cryo-EM), Micro-electron diffraction (Micro-ED), protein NMR or orthogonal structural biology technologies is preferred
  • Research experience with other biophysical techniques such as MST, ITC, NMR, DSF, SPR is preferred
  • Broad knowledge of biophysics, biochemistry, molecular pharmacology, and protein sciences is preferred.
  • Experience in scientific programming (Unix shells, Python) is preferred
  • Expertise in one or more of the following therapeutic areas: Oncology, Inflammation, Neuroscience, Cardiovascular, and Infectious Diseases is preferred

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Primary Location
United States-California-San Diego-
Organization
Janssen Research & Development, LLC (6084)
Job Function
R&D
Requisition ID
2005866689W


[Post Date: July 28, 2022]


Postdoctoral Fellow at University of Texas Health Science Center San Antonio

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Description:

My research group at UT Health San Antonio is looking for a creative and self-motivated Postdoctoral Fellow to study the structures and mechanisms of nucleic acid enzymes. We will use X-ray crystallography, cryoEM, and enzyme biochemistry to address basic mechanistic questions and develop drug candidates.

Below are some of our recent publications:

eLife. 2022 Jan 21;11. PMID: 35060905. doi.org/10.7554/eLife.67150

Nature Communications. 2021 Jun 2; 12: 3287. PMID: 34078893. doi: 10.1038/s41467-021-23594-y

Nature Communications. 2020 Jul 24;11(1):3718. PMID: 32709886. doi: 10.1038/s41467-020-17496-8

Applicants with prior experience in macromolecular crystallography and a strong interest in cryoEM studies and drug discovery are encouraged to apply. We already have crystals and cryoEM datasets available for an immediate start.

The Greehey Children’s Cancer Research Institute (GCCRI) is a unique, specialized cancer research center focusing on basic and translational research in childhood cancer and occupies a state-of-the-art 100,000 sq. foot research facility on the university’s Greehey Academic and Research Campus. The GCCRI has significant external funding, a large endowment from the state, and links to philanthropic entities. San Antonio is the nation’s seventh-largest city and is located at the edge of the beautiful Texas Hill County. San Antonio offers a rich, multi-cultural community, affordable cost of living, excellent weather, and a thriving biomedical industry.

Interested candidates can submit their application (CV, a brief description of their accomplishments, and contacts of 3 references) directly by email to me (Email: guptay@uthscsa.edu)


[Post Date: July 28, 2022]


Postdoctoral Positions in Viral RNA Structure & Function at Indiana University

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The Choi laboratory is moving to Indiana University, Bloomington, IN, and multiple post-doctoral positions are available.  We study the structure and mechanism of viral replication and infection machinery focusing on RNA viruses.  In particular, we are interested in RNA-protein interactions essential for viral RNA genome replication.  We use multiple approaches combining X-ray crystallography, cryo-electron microscopy (cryo-EM), biochemistry and biophysics.  For more information about our current research group, visit our website: https://www.utmb.edu/scsb/labgroups/choi/choi-research-lab.

Applicants should have a Ph.D. and experience in either biochemistry, X-ray crystallography or cryo-EM is required.  Interested parties should send a cover letter, CV, and a list of 2-3 references to Dr. Kay Choi via e-mail at kychoi@utmb.edu.

 


[Post Date: July 22, 2022]


Postdoctoral Associate – Wilson Lab – Structural Biology

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POSITION SUMMARY:
Fully-funded postdoctoral positions are available in the laboratory of Prof. Ian Wilson at Scripps Research (http://wilson.scripps.edu) for highly motivated candidates who are interested in immune recognition and inhibition of microbial pathogens. Specifically, we are looking for candidates interested in working on projects focused on structure-based design of vaccine candidates, as well as antibody and small molecule therapeutics against microbial pathogens. Candidates with prior experience in structural biology with interests in virology, immunology, infectious disease, antibody and antigen characterization, and design/development of vaccines and therapeutics, are encouraged to apply.
 
The Wilson laboratory research focuses on crystallographic studies of microbial pathogens, such as influenza virus, HIV-1, HCV, SARS-CoV-2 and P. falciparum malaria parasite. The major goals are to understand how the immune system combats viruses and other microbial pathogens through structural studies using high-resolution X-ray crystallography in concert with other biophysical and chemical biology approaches. We mainly focus on the analysis of antibody responses, definition of neutralizing epitopes, and use of that information to guide design of immunogens as potential vaccines as well as antibodies and small molecules as therapeutics. We also have interest in design of assays to aid in small molecule development against viruses, including influenza virus, in collaboration with chemical biologists and chemists. These projects involve working within multi-disciplinary groups of collaborators at Scripps Research and across the nation to tackle current and emerging global health threats. 
 
Make Scripps Research your next step to advance your research training. Click here to learn more about our Postdoctoral Program and Services:  https://education.scripps.edu/postdoctoral/
 
Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Faculty member. These appointments are normally not renewed beyond a total of five years.

REQUIREMENTS:
Must possess a doctoral degree.  A pending doctoral degree may be considered with approval of the Principal Investigator.
 
PREFFERED:
Ph.D. in structural biology or chemical biology, as well as a good foundation in biochemistry, immunology, and/or vaccinology. Prior experience in protein production and biophysical characterization is a plus. Candidates at both junior and senior levels are welcome to apply. Candidates should be fluent in English.
 
Compensation:
Commensurate with experience


[Post Date: July 22, 2022]


Postdoctoral Associate – Wilson Lab – Chemical Biology

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POSITION SUMMARY:
               
Fully-funded postdoctoral in chemical biology position is available in the laboratory of Prof. Ian Wilson at Scripps Research (http://wilson.scripps.edu) for highly motivated and skilled chemical biologist. Specifically, we are looking for candidates interested in working on projects focused on developing, synthesizing, and screening biological probes and therapeutics against microbial pathogens. Candidates with prior experience in organic chemistry, chemical biology including peptide and small molecule synthesis, drug development and HT screening and protein production are encouraged to apply. The candidate will be part of a multidisciplinary team of investigators with expertise in structural biology, biochemistry, chemistry, virology and immunology.
 
The Wilson laboratory research focuses on crystallographic studies of microbial pathogens, such as influenza virus, HIV-1, HCV, SARS-CoV-2 and P. falciparum malaria parasite. The major goals are to understand how the immune system combats viruses and other microbial pathogens through structural studies using high-resolution X-ray crystallography in concert with other biophysical and chemical biology approaches. We mainly focus on the analysis of antibody responses, definition of neutralizing epitopes, and use of that information to guide design of immunogens as potential vaccines as well as antibodies and small molecules as therapeutics. We also have interest in design of assays to aid in small molecule development against viruses, including influenza virus. These projects involve working within multi-disciplinary groups of collaborators at Scripps Research and across the nation to tackle current and emerging global health threats.
 
Make Scripps Research your next step to advance your research training. Click here to learn more about our Postdoctoral Program and Services:  https://education.scripps.edu/postdoctoral/
 
Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Faculty member. These appointments are normally not renewed beyond a total of five years.

REQUIREMENTS:
Must possess a doctoral degree.  A pending doctoral degree may be considered with approval of the Principal Investigator.
 
PREFFERED:
Ph.D. in biochemistry, chemistry or chemical biology. Prior experience in protein production and biophysical characterization is a plus. Candidates at both junior and senior levels are welcome to apply. Candidates should be fluent in English.
 
Compensation:
Commensurate with experience


[Post Date: July 22, 2022]


Postdoctoral Scientist - PNAC - Dr Roger Williams - LMB 1898

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Postdoctoral Scientist
Salary Range £32,302 to £35,143 per annum
Fixed term, 3 years
MRC Laboratory of Molecular Biology, Cambridge, UK

The MRC Laboratory of Molecular Biology is a research institute within UK Research and Innovation (UKRI).  UKRI is an entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org.

There is a post available to work within the group of Roger Williams at the MRC Laboratory of Molecular Biology (LMB), on a Cancer Research UK-funded programme aimed at understanding lysosomal control of cell proliferation and stress responses in cancer cells. This programme concerns regulation of VPS34, mTOR and ATM-containing kinase complexes. The work involves cryo-electron microscopy, X-ray crystallography, H/D exchange mass spectrometry and single-molecule kinetics as well as other biophysical and biochemical approaches. The candidate will join a team of researchers investigating phosphoinositide 3-kinase family members in large, reconstituted signalling assemblies that detect nutritional and stress signals.

This is a unique opportunity to play a major role in exciting programme, introduce new ideas, and disseminate research results, while working in a collaborative and supportive environment.

Candidates must have a Ph.D. degree (or be due to complete a Ph.D. within 6 months of applying) and should have a strong interest in structural biology. Ideally, the candidate would have some practical experience in single-molecule spectroscopy, computational molecular dynamics, single-particle cryo-EM, electron cryo-tomography, structural mass spectrometry or X-ray crystallography and experience with high-resolution cell imaging is also desirable. The ability to help foster collaborative spirit within the group and LMB is essential.

The successful applicant will be awarded a 3-year Career Development Fellowship/ Postdoctoral Training Scheme position.  This is a training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. The MRC LMB has excellent scientific core facilities and training opportunities.

This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply).

Working for UKRI MRC provides a whole host of benefits including a defined benefit pension scheme, excellent holiday entitlement (40 ½ days including bank holidays and privilege days) and Benenden Healthcare membership.  You will also have access to employee shopping/ travel discounts, on site sport and social facilities, as well as a salary sacrifice scheme for cycle to work.

It is anticipated that interviews will take place on 25th August 2022.

Closing date: Sunday 21st August 2022

Final appointments will be subject to a pre-employment screening.
The Medical Research Council is an Equal Opportunities Employer who participates in the Disability Confident scheme.


[Post Date: July 22, 2022]


Drug Discovery Scientist

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Description:

An opening is available in the drug discovery laboratory of Dr. Stephen Fesik for a candidate with experience in the field of protein x-ray crystallography or NMR.  Responsibilities will include protein production, fragment screening by NMR, and all aspects of x-ray crystallography including preparation of protein-ligand complexes, crystallization, home/synchrotron data collection, and structure determination. Additional experience in molecular biology including construct design, cloning, site-directed mutagenesis and modeling is a plus but not required.  The ideal candidate should be self-motivated and be able to communicate efficiently in a highly collaborative environment. Please send cv to jason.phan@Vanderbilt.Edu


[Post Date: July 13, 2022]


Post Doc - Structural Biology

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Our Company

At Boehringer Ingelheim we develop breakthrough therapies and innovative healthcare solutions in areas of unmet medical need for both humans and animals. As a family owned company, we focus on long-term performance. We believe that, if we have talented and ambitious people who are passionate about innovation, there is no limit to what we can achieve; after all, we started with just 28 people. Now, we are powered by 50,000 employees globally who nurture a diverse, collaborative and inclusive culture.

The Position

Take your chance to work with a state-of-the-art-structural biology group with dedicated protein biochemistry, biophysics, NMR, protein crystallography and cryo-EM capabilities.

You are a Structural Biologist with in-depth knowledge of molecular biology, protein biochemistry and biophysics as well as a strong interest to work in drug discovery?

If you want to work for a company that changes lives for the better, join our team within our Medicinal Chemistry department at our biggest research site!

Discover our Biberach site: xplorebiberach.com

This position is limited for two years.

Tasks & responsibilities

In your new role you will develop and evaluate approaches for the structure determination of medically highly relevant human membrane proteins, including G-protein coupled receptors (GPCRs).

The designing of expression constructs, screening expression and purification conditions is also part of your profile.

You will use biophysical methods for membrane protein characterization, including small-molecule binding.

Furthermore, you will determine 3D structures using state-of-the-art techniques (e.g., X-ray or cryo-EM).

Take the opportunity to collaborate with experts in the internal and external field to present your results and publish in peer-reviewed journals.

Requirements

  • PhD in Structural Biology, Biochemistry or a related field
  • Expert knowledge in Structural Biology, cryo-EM expertise is a plus
  • Expertise in molecular biology as well as in working with membrane protein expression in insect- or mammalian cell systems
  • Skills in the purification and characterization of integral membrane proteins,
  • Experience in working with GPRCs is an advantage
  • Excellent interpersonal skills paired with the ability to effectively interact with stakeholders both internally and externally
  • Fluency in English written and spoken


[Post Date: July 13, 2022]


Postdoctoral Associate

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A Postdoctoral Associate position is immediately available in the lab of Dr. Eddy Arnold. The Postdoctoral Associate will conduct research studying the structure and function of human viral proteins and polyproteins, including from SARS CoV-2, HIV-1, and an array of viruses that are significant pandemic threats. Determination of the structures of essential viral proteins including polymerases by cryo-electron microscopy and crystallography will contribute to structure-guided drug design. These studies will also lead to insights into fundamental mechanisms of polymerization, inhibition, and resistance. This is a grant-funded appointment contingent upon the continued availability of funds to support it.


[Post Date: July 13, 2022]


Senior Scientist, Structural Biology

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he department of Structural Biology at Genentech has an exciting opportunity for a Senior Scientist with a strong background in membrane protein biochemistry and structural biology to join our Membrane Protein group. This scientist will be responsible for the production of high-quality protein reagents to support small molecule drug discovery, antibody discovery, and lead finding efforts such as high-throughput screening, DNA-encoded library technologies and display-based selections. The scientist will also be expected to develop methods to improve the tractability of membrane proteins and facilitate drug discovery on this target class. A proven track record in optimizing the expression and purification of challenging proteins, in particular membrane proteins, for functional and structural studies is essential. Hands-on experience using different purification and reconstitution approaches and biochemical / structural characterization of membrane and membrane-associated protein complexes from recombinant or endogenous sources, is highly desirable.

In addition to expertise in protein biochemistry, this scientist will employ biochemical, biophysical, and computational methods to support structure-based drug design, antibody discovery, protein engineering approaches and elucidating function and mechanism of action through high-resolution structural analyses. Accordingly, proficiency in X-ray crystallography and/or cryo-EM methods and a passion to explore the structural basis of protein-protein and protein-ligand interactions is essential.

The successful candidate will be a technical expert who can lead from the bench as well as through collaboration with colleagues on multiple projects, in parallel.  Overall, you will be an outstanding structural biologist and collaborator who will have a significant impact on our portfolio, with the unique opportunity to help drive discovery projects from inception to early development.

Who You Are:

Required qualifications:

  • Ph.D. in biochemistry, biophysics, protein engineering, and/or structural biology with experience on multiple membrane protein targets. 

  • Productive postdoctoral training and/or industry experience is expected and should be reflected in an established track-record of high impact publications, patents or pipeline project transitions.

  • Experience level: 3-7 years post Ph.D.

Additional qualifications:

  • Hands-on experience engineering and optimizing the production of challenging membrane protein targets for structural and functional studies

  • Ability to generate and characterize milligram quantities of high-quality protein reagents

  • Experience with protein engineering and/or design approaches

  • Analysis, design, and/or computational approaches to investigate ligand-protein complexes

  • Experience with biophysical/biochemical assays to characterize protein conformation is a plus

  • Excellent communication, interpersonal and organizational skills

  • Fearless attitude to tackle longstanding difficult problems


[Post Date: July 13, 2022]


Post-doctoral positions for the study of signaling complexes using X-ray crystallography, Cryo-EM and NMR

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Description:

The Page Laboratory at the University of Connecticut Health Center has an immediate opening for up to two post-doctoral candidates to study eukaryotic signaling enzymes, with a focus on the function of phosphatases that form large signaling complexes and PPP drug/inhibitor development (SHP2, PPPs, PhosTacs). All studies combine X-ray crystallography and/or cryo-EM/NMR with biochemical and in situ experiments, allowing post-docs to augment their training in those techniques that are new. Applicants with a strong backgrounds in biochemical techniques, and especially eukaryotic protein expression and protein crystallization, are encouraged to apply.

The Page laboratory is housed in a newly renovated ~250,000 sq. ft. research laboratory in Farmington, CT. The laboratories are open-lab-space facilities and allow close interaction with the adjunct structural biology and molecular/cell biology groups at UConn Health. The Page laboratory is equipped with all necessary infrastructure to produce (E. coli, Sf9, mammalian), purify and analyze protein and protein complexes (ITC, SPR etc.) and crystallization robotics for crystal production (Art Robbins Gryphon LCP nano-liter crystallization robot; Art Robbins CrysCam).

Outstanding UCHC facilities include a Bruker Venture D8 system (IμS Diamond source) with a Photon III M14 detector and cold stream is available for crystal screening and data collection for in-house data collection, synchrotron access at NSLS-II, SSRL, Diamond and high-field NMRs (Bruker Avance Neo 600 MHz and 800 MHz NMR spectrometers (installed in 2021). Both spectrometers are equipped with four independent channels for 1H, 13C, 15N and 2H observation and decoupling and TCI-HCN cryo-probes (1H, 13C, 15N cooled).

UCHC has a welcoming, collaborative and vibrant environment for structural, biochemical and translational research. Farmington, CT, is located in New England between Boston (90 min.) and New York City (90 min). Starting date, salary and project details are negotiable.

Please e-mail a Cover Letter and CV to Rebecca Page (rpage@uchc.edu).


[Post Date: July 13, 2022]


Postdoctoral position on function and regulation of macromolecular assemblies - Dept of Structural Biology, Genentech

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Description:

We're looking for a talented and highly motivated postdoctoral fellow to join my group in the Department of Structural Biology at Genentech to study the function and regulation of macromolecular assemblies important in fundamental cellular processes and human disease.

The position is available immediately and fully funded for up to four years. The postdoc will have the unique opportunity to work in a highly collaborative research environment on diverse projects such as investigating T cell receptor signaling and the regulation of kinetochore assembly and function. The postdoc will be able to independently pursue projects and grow their expertise in X-ray crystallography and cryo-EM, with access to state-of-the-art lab equipment, high resolution cryo-EM technology and a virtually unlimited computer cluster for data processing.

The Department of Structural Biology at Genentech is a scientifically rich and highly stimulating research environment that has a strong track record in mentoring postdocs and collaborating with other research groups at Genentech and in the academic community.

Who you are:

  • Completed or in the last year of a Ph.D. in structural biology, biochemistry or a related field of research.
  •  Demonstrated expertise in protein purification, biophysical characterization and structure determination by X-ray crystallography and/or single-particle cryoEM of multi-protein complexes as shown by a strong record of first-author publications in high quality journals.
  • Experience in protein engineering, biophysical characterization methods for protein-protein and protein-nucleic acid interactions, such as surface-plasmon resonance (SPR), Isothermal Titration Calorimetry (ITC), or bio-layer interferometry (BLI) and in vitro assay development will be beneficial.
  • Self-motivated and detail-oriented, driven to solve complex scientific problems independently and in a collaborative environment.
  •  Strong oral and written communication skills are required.

If interested, please contact me directly (dimitrova.yoana at gene.com) and include a copy of your CV.

The Genentech Postdoctoral Program is unique in the pharmaceutical industry with a vibrant community of mentors and fellows. More Information about the Genentech Postdoctoral Program:
http://www.gene.com/careers/academic-programs/postdocs


[Post Date: July 8, 2022]


Postdoctoral Position in Biochemistry of Cyanobacterial CO2 Fixation

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Description:

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has over 54,000 students, more than 7,500 employees and a turnover of around SEK 8 billion.

The Department of Chemistry - Ångström conducts research and education in the chemistry field. The department has more than 250 employees and has a turnover of 250 million SEK. At the department's six programs, we conduct very successful research of a high international standard. We have a large number of externally funded research projects, often with international cooperation and we see continued good growth in our subject area. The department has education assignments in engineering programs and master's programs. More information is available on our website.

We are searching for a biochemist, structural biologist, biophysicist or similar for a 2 year postdoc position within Cecilia Blikstad’s group. Research within the group focus on biochemical investigations of CO2 fixation in cyanobacteria. 

Rubisco is responsible for the majority of CO2 fixation on Earth. Despite this centrality, it is a relatively slow and promiscuous enzyme. To overcome this, cyanobacteria have evolved a CO2 concentration mechanism (CCM) which produces a high CO2 concentration near Rubisco and ensure efficient carboxylation. The CCM consist of inorganic carbon transporters that actively accumulate bicarbonate in the cytosol and a protein based bacterial organelle called the carboxysome. 

The carboxysome encapsulate Rubisco and carbonic anhydrase within a protein shell. It remains unknown exactly how this 250+ megadalton protein complex self-assembles and regulates with high fidelity inside cells. We use a combination of biochemistry, enzymology, structural biology, synthetic biology and bioinformatics to study various aspects (function, structure, assembly, regulation etc.) of the cyanobacterial CO2 concentrating mechanism. You will work in a project focusing on protein interactions, regulation, and activity of the carboxysome and its encapsulated enzymes. The acquired knowledge will lead the way for downstream applications aiming at enhancing photosynthetic efficiencies in future microorganisms and crops. For more information visit the lab website .  

At the department we have a close collaboration with experts in cyanobacterial synthetic biology and our combined greater goal is to address global warming and food shortage by converting atmospheric CO2 into valuable products such as biofuel, specialized chemicals and food. We have a highly creative research environment, and our projects provide many opportunities for interaction and collaboration within the department as well as with outside collaborators. 

Read more about our benefits and what it is like to work at Uppsala University

Duties
The main duties involved in this postdoctoral posistion is to conduct research within the subject area mentioned above. Supervision of degree projects and doctoral students. Teaching may also be included, but up to no more than 20% of working hours. 

Requirements
For employment as postdoc, the applicant should have a PhD exam or an international equivalent within the field of biochemistry, structural biology, biophysics, biotechnology or other for the position relevant fields. The degree needs to be obtained by the time of the decision of employment. Those who have obtained a PhD degree three years prior to the application deadline are primarily considered for the employment. The starting point of the three-year frame period is the application deadline. Due to special circumstances, the degree may have been obtained earlier. The three-year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc.

Very good oral and written proficiency in English.

The assessment of applications is based primarily on the applicant's ability to conduct independent research based on scientific skill. Greater importance is attached to the quality of individual scientific work, than to the amount of publications. 

Large enphasis will be put on personal qualities. Consideration will be given to good collaborative skills, good analytical skills, drive and independence, and interest in the subject area. 

Additional qualifications
Advanced knowledge and/or practical experience in the following will be beneficial.

  • Practical and theoretical skills in biochemistry and/or structural biology or similar.
  • Cunducting, interpretating and publishing biochemical studies.
  • Experience in protein biochemistry including but not limited to protein purification, protein-protein interactions, enzymology or structural biology.
  • Experience in molecular biology including but not limited to molecular cloning.
  • Experience in photosynthetic microorganisms will be considers benificial but not required.  

About the employment
The employment is a temporary position of two years according to central collective agreement. Scope of employment 100%. Starting date 2022-10-01 or as agreed. Placement: Uppsala, Sweden

For further information about the position, please contact: Cecilia Blikstad, cecilia.blikstad@kemi.uu.se.

Please submit your application by 23rd August 2022, UFV-PA 2022/2730

Are you considering moving to Sweden to work at Uppsala University? Find out more about what it´s like to work and live in Sweden.  

Please do not send offers of recruitment or advertising services.

Submit your application through Uppsala University's recruitment system.

Placement: Department of Chemistry - Ångström Laboratory

Type of employment: Full time , Temporary position longer than 6 months

Pay: Fixed salary

Number of positions: 1

Working hours: 100%

Town: Uppsala

County: Uppsala län

Country: Sweden

Union representative: Seko Universitetsklubben seko@uadm.uu.se
ST/TCO tco@fackorg.uu.se
Saco-rådet saco@uadm.uu.se

Number of reference: UFV-PA 2022/2730

Last application date: 2022-08-23


[Post Date: July 5, 2022]


PhD student or Postdoc Max Planck Institute for Multidisciplinary Sciences

View the Job Posting Here

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Description:

The Max Planck Institute for Multidisciplinary Sciences is a leading international research institute of exceptional scientific breadth. With more than 40 research groups and some 1,000 employees from over 50 nations, it is the largest institute of the Max Planck Society.

The research group Ubiquitin Signaling Specificity (Dr. Sonja Lorenz) invites applications for a position as

PhD student or Postdoc (f/m/d)
Specificity mechanisms in the ubiquitin system

Our lab aims to understand how the protein modifier ubiquitin achieves specificity in regulating virtually all aspects of eukaryotic homeostasis. A major key lies in the action of ubiquitin ligases, the most diversified class of enzymes in the ubiquitin system with powerful therapeutic potential. However, progress towards rationally manipulating these enzymes has been impeded largely by our insufficient understanding of their conformational dynamics, macromolecular interactions, and functional integration into cellular pathways. We offer fully-funded PhD student or postdoc positions to explore different aspects of specificity in ubiquitination: (i) the macromolecular network of ubiquitin ligases in the cell and associated functions; (ii) the cross-talk of ubiquitination with other posttranslational modifications, such as phosphorylation and redox-dependent modifications; (iii) the structural mechanisms of ligases at the ribosome. Exciting projects with either structural or biochemical or cell biological focus are available and will be tailored to the interests and expertise of the successful candidates.

PhD candidates should hold/soon expect a MSc or equivalent degree in a relevant area of the life sciences and have initial experience in one or more of the following techniques: protein biochemistry, cell biology, chemical biology, or any aspect of structural biology.

Postdoctoral candidates should hold/soon expect a PhD or equivalent degree in a relevant area of the life sciences and have a proven track record in one or more of the following techniques: cryo-EM, X-ray crystallography, isolation/reconstitution of protein complexes, or cell biology (e.g., Crispr/Cas9-mediated gene editing, RNA interference, co-IP or IF). Additional experience or interest in mass spectrometry/proteomics will be beneficial.

Candidates for either position should be curiosity-driven, self-motivated, passionate about science, and eager to work in an international, multi-disciplinary team.

We offer

  • competitive research in an inspiring, world-class environment
  • professional training, networking and career-development opportunities; free language courses
  • on-site health management: free fitness and yoga room, sports groups, beach volleyball league, and courses for a "moving lunch break”
  • a wide range of opportunities to balance work and family life, including an on-campus kindergarten and vacation care
  • spacious on-site cafeteria with diverse meals; espresso bar
  • initiatives for sustainability and a green environment with an on-site biotope

About us

Based at one of Germany’s premier research campuses, our research group has access to leading-edge infrastructure in all areas of cell and structural biology, including cryo-EM. We are an international team, supported by the Max Planck Society, the German Research Foundation, and the EMBO Young Investigator Program. Our working language is English; knowledge of German is not required. The historic city of Göttingen, located in the center of Germany, offers great outdoor and cultural opportunities, a vibrant student scene, and an impressive scientific heritage.

Position details

The positions should be filled as soon as possible; the exact start date is flexible. PhD students will be funded for three years (with a possibility of extension) and have the opportunity to enroll in one of several PhD programs in collaboration with the University of Göttingen. Postdoc positions are initially funded for two years with a possibility of extension. Payment and benefits are based on the TVöD (wage agreement for public service personal) guidelines.

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and encourages applications from such qualified individuals. The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds.

Application

Please submit your application including a cover letter (explaining background and motivation), CV, academic transcripts, publication list, and the contact addresses of 2 references as a single PDF file to the email address below. Review of applications will begin immediately.

ausschreibung34-22@mpinat.mpg.de

Max Planck Institute for Multidisciplinary Sciences
Research Group „Ubiquitin Signaling Specificity
Dr. Sonja Lorenz
Am Faßberg 11
37077 Göttingen
Germany

Twitter: SLorenzLab


[Post Date: July 5, 2022]


Protein Crystallographer

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Description:

Company Description

Sosei Heptares is an international biopharmaceutical company with a mission to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design, and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected technology and platform.

Our core focus is on the discovery and early development of new medicines originating from our proprietary G Protein-Coupled Receptor (GPCR) targeted StaR® technology and Structure Based Drug Design (SBDD) platform capabilities. Today, we are advancing a broad and deep pipeline of novel medicines across multiple therapeutic areas, including neurology, immunology, gastroenterology, and inflammation diseases.

We have established partnerships with some of the world’s leading pharmaceutical companies and multiple emerging technology companies, including AbbVie, AstraZeneca, Biohaven, Genentech (Roche), GSK, Neurocrine Biosciences, Novartis, Pfizer, Takeda and Verily.

Sosei Heptares is headquartered in Tokyo, Japan with corporate and R&D facilities in London and Cambridge, UK. We have approximately 170 employees based at our state-of-the-art R&D research centre at Granta Park, Cambridge. The size of our company ensures optimum agility and transparent linkage between all activities from early discovery through to clinical development.

For more information, please visit https://soseiheptares.com/. LinkedIn: @soseiheptaresco | Twitter: @soseiheptaresco | YouTube: @soseiheptaresco

Position

We are currently seeking an experienced protein crystallographer to join the crystallography team within the Biomolecular Structure department responsible for the structure determination of membrane proteins to support Sosei Heptares’ drug discovery efforts.

This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company.

The successful candidate is expected to:

  • Express and purify soluble and integral membrane proteins for biophysical and structural characterisation
  • Set up and optimise crystallisation experiments
  • Screen crystals and collect diffraction data remotely at synchrotron sources
  • Determine, build, refine and validate crystal structures
  • Maintain and update crystallographic software and pipelines within a Linux environment
  • Propose, develop, implement, optimise, and maintain workflows and pipelines to accelerate structure determination using X-ray crystallography
  • Prepare and effectively present results (written and oral) to project teams (internal and external)
  • Have strong interpersonal skills and interact effectively with collaborators (internal and external) across a wide range of disciplines including Pharmacology, Medicinal Chemistry, and Computational Chemistry

Requirements

Our preferred candidate will have the following:

  • PhD in protein crystallography or a related discipline
  • Experience in protein purification from recombinant expression systems (bacterial, eukaryotic)
  • Experience in soluble and/or membrane protein biochemistry and structural biology
  • Extensive experience in setting up and optimising crystallisation experiments
  • Proficiency in crystal screening, data collection and processing, structure determination, building and refinement
  • Significant experience in a variety of data integration and processing software packages
  • Demonstrated experience in shell and python scripting
  • Experience in high-throughput crystallography
  • Understanding of GPCR and other integral membrane proteins (transporters, ion channels) structures and mechanisms
  • Experience working in a drug discovery environment where X-ray diffraction structural studies are used to inform ligand design
  • Excellent organisational skills

What’s in it for you?

  • State-of-the-art R&D centre located in the heart of the Cambridge science cluster
  • Competitive compensation package including discretionary cash bonuses
  • Eligible for grants of Restricted Stock Units in Sosei Group Corporation
  • 25 days annual leave in addition to public holidays
  • Employer contribution to pension
  • Private Medical Insurance and a cash plan for dental and optical reimbursement
  • Health and wellbeing benefits including a subsidised individual gym membership
  • Income protection to cover long term absences due to ill health
  • Group Death in Service equal to 4x basic annual salary

Why Sosei Heptares?

At Sosei Heptares, we are dedicated to the pursuit of scientific innovation. Our mission is to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design, and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected technology and platform

Working at Sosei Heptares

The Sosei Heptares R&D centre is a modern, state-of-the-art centre located within easy shuttle reach of Cambridge and Whittlesford Parkway train stations. We offer a collaborative, diverse and inclusive working environment that considers your individual needs and believes in maintaining a sustainable work-life balance. You will be welcomed by a team of colleagues with decades of accumulated experience in their areas of expertise, happy to help you develop your own skills in a highly collaborative environment and who are keen to provide guidance and support in your personal and career development plans.

Our Vision and Values

To become one of Japan’s science and technology-led biopharmaceutical drug discovery champions. To achieve this, we will leverage our global know-how and operating agility to deliver a sustainable pipeline of first or best-in-class therapeutics, ensuring our place amongst the next generation of leading innovators.

We are guided by three fundamental values.

  • Limitless Compassion
  • Unswerving passion
  • Continuous self-innovation

These unchanging set of core values that serves as a guide across all our activities

Join Us!

Other information

The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation.

Sosei Heptares is committed to building a diverse and ambitious workforce, and to promoting equal opportunities in employment. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment: we do not discriminate based on age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, or any other classification prescribed by law.

Applications should include a CV and covering letter, providing a short description of your background and interest in the role. Please apply through our on-line job’s portal with your application in pdf format, quoting reference number 2022-Crystallography-BMS. The closing date for applications is 30TH Sept 2022.

For more information about Sosei Heptares and how we use your data please go to: https://soseiheptares.com/privacy-notice


[Post Date: June 28, 2022]


Senior Scientist in Antibody Engineering

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Description:

Job Summary

ModeX Therapeutics is seeking a highly talented and motivated research scientist with expertise in the field of antibody engineering to join our team.  The candidate will be part of an established multidisciplinary team advancing discovery efforts on our earlier-stage programs as well as moving novel therapeutic antibodies into clinic.  The individual will work in the state-of-the-art laboratory and is responsible for experimental design, execution, data analysis, and record keeping and presentation.  This is an exciting opportunity to be part of a cross-functional team and contribute to the development of cutting-edge biotherapeutics in a fast-paced, rapidly growing biotech company with a bold vision. 

Company

ModeX Therapeutics, a subsidiary of OPKO Health, is a biotech startup based in Massachusetts dedicated to the concept of modulating multiple disease targets with innovative multi-targeting strategies. It was founded by Dr. Elias Zerhouni and Dr. Gary J. Nabel in 2020 with a team of scientists with proven track record from early research to clinical development, regulatory approvals, and commercialization. ModeX is pursuing the development of novel immune-oncology therapeutics for cancers and biotherapeutics against infectious disease.

Major responsibilities

  • Interact closely and be part of interdisciplinary biologics research teams to drive the discovery of innovative therapeutic antibodies and the optimization of their biological and biophysical properties.
  • Contribute to ModeX’s multi-targeting strategy through antibody discovery campaigns and structure-based antibody design.
  • Develop and implement high-throughput antibody expression and purification platforms. Enhance optimization of workflows
  • Immunogen immunization strategy design. Single B cell sorting and/or screening technologies.
  • Interpret results and present/communicate with cross-functional colleagues for successful execution and completion of projects.
  • Stay scientifically current and contribute to the implementation of new technology and instrumentation.
  • Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks.

Qualifications

  • PhD in biochemistry, structure biology or other life science disciplines with 3+ years of relevant experience antibody engineering.
  • Hands-on experience in antibody generation and optimization (affinity modulation, humanization, PTM mitigation, etc.) in an industrial setting with strong track record of delivery of high quality antibodies.
  • Expertise in immunology, B cell biology, cloning, next gen. sequencing and data analysis. Hands on experience in hybridoma/B cell cloning, automation, Elisa, BLI/SPR, and FACS.
  • Knowledge in protein engineering using direct evolution methods such as yeast surface and mammalian display.
  • Knowledge in antibody structure and experience in structure-based protein engineering is preferred.
  • Computer skills, including large dataset analysis and basic scripting
  • Excellent written and oral communication, organization, and data analysis skills.  Outstanding troubleshooting and problem-solving skills.
  • Highly adaptable to a fast-paced work environment and capable to work both independently and collaboratively within project teams.

To apply, please send cover letter and CV to Ronnie.Wei@ModeXTX.com and careers@ModeXTX.com


[Post Date: June 23, 2022]


Postdoc Curie Institute

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Description:

The Structural Motility team is searching for a post-doctoral fellow to join a dynamic laboratory directed by Anne Houdusse at the Curie Institute (Paris Center).

We are looking for an expert in biophysics/biochemistry and structural determination to gain insights on how drugs in phase 3 clinical trials operate for novel therapies against cardiac diseases.  The position will also lead to the development of chemical biology tools. Our team indeed innovate to investigate and understand molecular mechanisms in cells. By joining our team, the post-doctoral fellow will also join efforts on determination of structures by cryoEM and will increase his/her knowledge on the cytoskeletal by functional and cellular studies. 

Our team studies the mechanism and function of force production by molecular motors and has made important discoveries on how force generation can power cellular processes in human health and how mutations in their function lead to disease.  A multi-disciplinary approach that combines structural biology (x-ray and cryoEM), chemical biology and cell biology is being used in our studies.  With such an approach, we decipher how molecular motors produce force by visualizing yet unknown structures, or by understanding how their activity is regulated. We use chemical biology and cell biology approaches to test insights from structures.  We also investigate and develop specific modulators of the force generated by these motors (including compounds in phase 3 clinical trials) to investigate how force modulation can lead to new therapies. 

We are looking to recruit and train a dynamic and motivated candidate who can quickly gain independence and take the lead on one of our exciting scientific projects.  Experience in cryo-electron microscopy or cell biology is a plus.

If you are interested, please send a CV and a statement of research interests and goals as well as three letters of recommendation from your previous employers.

Contact : Anne Houdusse (anne.houdusse@curie.fr)

Website : Structural Motility Team https://institut-curie.org/team/houdusse


[Post Date: June 21, 2022]