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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Postdoc Umeå University
Website: https://barandunlab.org/

Description:
Postdoctoral position in structural biology to study infection related processes

Research group

Our research group is located at the University of Umeå and affiliated with the Molecular Infection Medicine Institute Sweden (MIMS) and Science for Life Laboratory (SciLifeLab). We are using a combination of in vivo assays, biochemistry and cryo-electron microscopy to study macromolecular complexes of specialized pathogenic organisms (prokaryotes and eukaryotes). We aim to provide a molecular basis of key mechanisms in the infection process and uncover unique structural determinants that could serve as novel targets for antibiotics.

Requirements

We are seeking an independent researcher with experience in genome manipulation using CRISPR/Cas9 who would like to apply state-of-the-art techniques in cryo-electron microscopy to study infection related processes in a pathogenic organism. The project involves establishing genomic manipulation tools, reconstitution of a unique infection mechanism in heterologous expression systems and structural studies using cryo-electron tomography and single particle analysis.

Highly motivated candidates who would like to work in a young and dynamic team are encouraged to apply. A background in molecular biology, genome manipulation (CRISPR/Cas9) and biochemistry is required and experience with C. elegans and structural biology a plus. Please contact me with a CV, short letter of motivation and contact information for at least 2 reference persons.

Contact information

Jonas Barandun
jonas.barandun@umu.se


[Post Date: January 15, 2019]

Title: Postdoc Francis Crick Institute
Website: https://www.crick.ac.uk/research/labs/katrin-rittinger/vacancies

Description:
We are looking for a highly motivated structural biologist to join the group of Katrin Rittinger at the Francis Crick Institute as a postdoctoral fellow. Work in the group is focused on defining the regulatory mechanisms that underlie protein ubiquitination.
The successful applicant will use a wide range of approaches including structural biology techniques (X-ray crystallography and cryoEM), biochemistry, structural mass spectrometry (XL-MS, HDX and native MS) and cell biology to study the structure and function of TRIM family E3 ubiquitin ligases.


[Post Date: January 15, 2019]

Title: Postdoc University of Wisconsin-Madison
Website: https://biochem.wisc.edu/faculty/butcher

Description:
A postdoctoral position is immediately available in the laboratory of Professor Samuel Butcher at the University of Wisconsin-Madison.

The Butcher laboratory is funded by the NIH to investigate the structure and function of RNA-protein complexes that regulate gene expression. Additionally, the lab is currently determining structure activity relationships for small molecules that regulate non-coding RNAs that play roles in neurodegenerative diseases.

The Butcher laboratory is part of a vibrant research community at UW-Madison with state-of-the-art resources, such as the National Magnetic Resonance Facility at Madison (NMRFAM) and a newly established cryo-EM facility that will soon house a Titan Krios, Talos Arctica and Aquilos FIB/SEM electron microscope.

The Butcher laboratory has established expertise in NMR, X-ray crystallography, SAXS, and myriad biophysical techniques. Additionally, we collaborate with local experts in cryo-electron microscopy. Thus, postdoctoral trainees in the Butcher lab are in a position to learn any aspect of contemporary structural biology.

Recent publications:
www.ncbi.nlm.nih.gov/pubmed/30215753
www.ncbi.nlm.nih.gov/pubmed/29717126
www.ncbi.nlm.nih.gov/pubmed/28887445
www.ncbi.nlm.nih.gov/pubmed/27194769
www.ncbi.nlm.nih.gov/pubmed/26655855
www.ncbi.nlm.nih.gov/pubmed/24837192

Requirements are a PhD in biochemistry or related scientific field. If interested, please send CV by email to: sebutcher@wisc.edu


[Post Date: January 14, 2019]

Title: Postdoc University of Western Australia
Website: https://goo.gl/vHgno1

Description:
Post-doctoral Research Associate - Protein Biochemistry

Job no: 502578
Work type: full-time, 3 years
Location: Crawley, Perth, WA
Salary: Level A Step 8 $92,497 p.a. plus 17% superannuation

Exceptional opportunity for an innovative and motivated post-doc to work with a multi-disciplinary team of researcher on a 3 year full time appointment.

Faculty of Science, School of Molecular Sciences, The University of Western Australia

Working within the Plant Biological Chemistry laboratory within the School of Molecular Sciences, you will be reporting to Associate Professor Joshua MyIne. The laboratory is comprised of a mix of protein biochemists, geneticists and bioinformaticians, forming a multi-disciplinary team environment undertaking a diverse range of plant biochemistry, protein evolution and chemistry research projects.

In this position, you will be responsible to undertake innovative laboratory-based research to identify and study novel herbicide targets. You will use biochemical (e.g. recombinant proteins, protein crystallography, enzyme assays) approaches to further our understanding. The successful appointee will be encouraged to develop their own research ideas along the lines of the research interests of the group, and to work collaboratively within the multidisciplinary environment of the Plant Biological Chemistry Laboratory, the School of Molecular Sciences and the ARC Centre of Excellence in Plant Energy Biology.

To be considered for this role, you will demonstrate:

- PhD in Biochemistry, Molecular Biology or related discipline
- Experience in recombinant protein production
- Experience in protein biochemistry, enzymology, structural enzymology, protein crystallography, chemical biology, structural biology (preferred)
- Good interpersonal skills and the ability to work well independently and within a team
- Good computing and data management skills
- Experience preparing manuscripts for publication in international journals and supervising students

For more information regarding the position or a confidential discussion, please contact: Associate Professor Joshua Mylne, School of Molecular Sciences, email: joshua.mylne@uwa.edu.au

Full details of UWA job #502578 are at https://goo.gl/vHgno1

Applications close 15 February 2019.


[Post Date: January 14, 2019]

Title: Research Associate/Assistant Professor

Description:
Research Associate/Assistant Professor positions
Research Associate/Assistant Professor positions are immediately available in the Laboratory of Antibody Structure (PI: Prof. Ian Wilson) at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University (http://siais.shanghaitech.edu.cn/eng/research7.asp). SIAIS is an innovative research institute dedicated to the fundamental problems in life science, particularly in the fields of immunochemistry, structural biology, immunology and virology, computational biology, cell and molecular biology.

The Lab of Antibody Structure utilizes a multidisciplinary approach, which embraces x-ray crystallography, cryo-EM, bio-mass spectrometry, and other biophysical methods, to study the host entry of various pathogens and their interaction with host cells and immune system, with a long-term goal of understanding and modulating the functions of important host receptors and immune effectors for the prevention and treatment of microbial infections, immune disorders, or cancers.

We are now seeking self-motivated and creative researchers to join our team. Candidates for Research Associate/Assistant Professor positions should:

--- hold a Ph.D. degree in fields relevant to the Lab interests, including structural biology, bioinformatics, immunology and biochemistry)
--- have a strong research background in related fields
--- have a publication record commensurate with experience
--- manifest good problem solving, interpersonal and communication skills
Some particular areas of interest for new appointments are:
--- experience in membrane protein expression/purification and membrane protein crystallography or cryo-EM
--- experience in electron tomography of viruses
--- experience in integrative modeling
--- experience in small angle x-ray scattering (SAXS) and familiarity with ITC/Biacore/DSC instruments.

Besides taking responsibilities for his/her own and collaborative projects, the candidates are also expected to help train and supervise graduate students, postdoctoral fellows, and technicians. The candidates will benefit from the world-class academic environment as well as easy access to SSRF beamlines for macromolecular crystallography and SAXS, and state-of-the-art cryo-EM instruments (two Titan Krios/K2, Talos Artica, and other microscopes) installed close to our lab at ShanghaiTech University.

If interested, please send a cover letter, a curriculum vitae with publication list and list of three referees to hr_siais @shanghaitech.edu.cn (cc: wilson@scripps.edu and yangbei@shanghaitech.edu.cn). Title and salary will be commensurate with experience. The positions will remain open until filled.


[Post Date: January 11, 2019]

Title: Structural Biology Platform Manager
Website: https://www.icr.ac.uk/

Description:
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally. The ICR is committed to attracting, developing and retaining the best minds in th
e world to join us in our mission – to make the discoveries that defeat cancer.
Research in the Division of Structural Biology is aimed at understanding the structural basis for the function and regulation of proteins and protein complexes implicated in cancer. Our research programmes are complemented by close collaborations with other groups elsewhere in the Institute, including groups from the Divisions of Cancer Biology and Cancer Therapeutics, and provide the mechanistic and structural framework for developing new therapeutics targeting cancer. The Division of Structural Biology is well equipped with state of the art in-house X-ray equipment and robotics, computational infrastructure, an in-house electron microscopy facility (including a high-end 200keV microscope equipped with a direct electron camera and Volta phase plate to be installed in 2019) and has direct access to a 300 keV Krios microiscope, as part of the LonCEM consortium.

A position to manage the Structural Biology Platform is available in the Division of Structural Biology (ref 620). The Structural Biology Platform manager will be directly responsible for the smooth operation of the Division’s crystallisation infrastructure, including in-house X-ray crystallography equipment and will also be involved in the development and maintenance of the EM facility together with other existing staff members. The post holder will coordinate the EM, crystallographic and SAXS data collection experiments at synchrotron radiation sources and Block Allocation Group (BAG) beam time applications, and the training of new staff and PhD-students. In addition, the post holder will be responsible for the maintenance and running of the biophysical equipment of the Division.

Applicants must have a PhD in a biological or physical science, and experience in macromolecular crystallography (to include, protein crystallisation, & protein crystallography) and have considerable postdoctoral experience. Experience in molecular biology, biophysics, an/or electron microscopy will be an advantage.
The starting salary for the position will be in the range £42,792 to £50,943 p.a. inclusive (based on previous experience) and the post is non time limited.

Please apply via the e-recruitment system on our website www.icr.ac.uk. Closing date: 10th February 2019


[Post Date: January 11, 2019]

Title: Open positions at MFPL Vienna
Website: https://www.falklaboratory.org

Description:
Open positions at MFPL Vienna

Currently recruiting a technician, a PhD student (via the MFPL PhD Program) and a summer student (via the Vienna BioCenter summer school).

For more information about the group:
https://www.falklaboratory.org

Please follow the links below for the indiviual positions:

Technician:
http://bit.ly/2H5L2Yd

PhD position (Deadline of MFPL Spring Selection: March 3rd, 2019):
http://www.mfpl.ac.at/de/training/phd-opportunities/how-to-apply.html

Summer school (Deadline January 31st, 2019):
https://www.training.vbc.ac.at/summer-school/

Our group is interested in unraveling the molecular mechanisms that allow the establishment of a robust RNA interference (RNAi) response in which small RNAs are used to silence the expression of genes. We are particularly interested in understanding how the nuclear RNAi pathway leads to heterochromatin formation. We will address these questions by reconstituting and characterizing the protein complexes involved in these pathways both biochemically and structurally. For the structural characterization, we employ an integrative approach by combining X-ray crystallography and single-particle electron microscopy. This will be complemented by biochemical approaches (enzyme activity assays) and biophysical assays (isothermal titration calorimetry, analytical ultracentrifugation, and spectroscopic methods).


[Post Date: January 11, 2019]

Title: Group Leader in Structural Biology

Description:
Viva Biotech, located in Shanghai, China, is specialized in structure-based drug discovery providing preclinical drug discovery research services to global pharmaceutical and biotech companies. We have opening for group leaders in structural biology and biochemistry. Anyone who is interested in the position, please send CV to hr@vivabiotech.com

Job title: Group Leader in Structural Biology or Biochemistry

Job description

We are seeking highly motivated individuals with experience in protein biochemistry and structural biology. Candidates will lead the structural biology team to carry out the biochemistry studies and/or gene-to-structure studies which elucidate the interactions between small molecules/peptides and their targets. Experiences with protein expression and purification, excellent interpersonal and managerial skills, team player with excellent written and verbal communication skills and proficiency in structure biology related software. Excellent communication skill in English; 3-5 years working experiences with in US or Europe.

Qualifications

1) Ph.D. in crystallography or protein biochemistry training with minimal 3-5 years’ working experience

2) Hands-on experience in protein crystallization, and protein expression and purification is optional.

3) Proficient in structure biology related software is plus.

4) Demonstrated managerial skill to guide groups through corporate change and growth.

5) Excellent verbal and writing skills in both English and Chinese are mandatory.

6) Strong communication skills and client interaction are required.


[Post Date: January 10, 2019]

Title: PhD Position St Jude
Website: https://www.stjude.org/fischer

Description:
The Fischer lab at St. Jude Children’s Research Hospital is recruiting a graduate student for a project that exploits protein dynamics for ligand discovery against pediatric cancer targets.

You will be part of a young interdisciplinary team that uses structural biology (crystallography, NMR), protein biochemistry, and single-molecule methods (smFRET, HDX-MS) to characterize dynamic, disease-relevant protein states. By finding ligands against those flexible protein states, and revealing allosteric networks we can explore new ways to modulate protein malfunction in disease.

The project will be housed in the Department of Chemical Biology and Therapeutics (https://www.stjude.org/research/departments-divisions/chemical-biology-therapeutics.html), and Structural Biology (https://www.stjude.org/research/departments-divisions/structural-biology.html) at St. Jude Children’s Research Hospital. With ongoing investments into exceptional structural biology, chemical biology and computational facilities, this is an exciting time to join the lab.
Accompanying courses will be taken in conjunction with the Department of Pharmaceutical Sciences at the University of Tennessee Health Science Center.

This work will provide a solid introduction to current opportunities in structure-based ligand discovery with relevance for both academia and industry. With its excellent core facilities, highly interactive and supportive environment St. Jude Children’s Research Hospital is a great place to do research and build a career whilst living in an affordable city.

Admission requirements:
- a BS or MS degree in pharmacy, chemistry, biology, mathematics, engineering, or other appropriate disciplines.
- a minimum Grade Point Average of 3.0
- a combined Graduate Record Examination score (verbal and quantitative) of at least 300
- proof of proficiency in English (e.g. TOEFL)

Please direct your questions and application package including a cover letter, current CV, and 3 letters of reference to: Dr. Marcus Fischer (marcus.fischer@stjude.org) before the end of February 2019.

Online application deadline is March 15thfor admission to the Fall Semester starting in August 2019.


Relevant papers include:
• Fischer et al. (2014). Incorporation of protein flexibility & conformational energy penalties in docking screens to improve ligand discovery. Nature Chemistry6, 575-83. PMID 24950326
• Balius et al. (2017). Testing inhomogeneous solvation theory in structure-based ligand discovery. PNASE6839-46. PMID 28760952
• Fischer et al. (2015). One crystal, two temperatures: cryocooling penalties alter ligand binding to transient protein sites. Chembiochem1560-64. PMID 26032594

More info at: https://www.stjude.org/fischer


[Post Date: January 10, 2019]

Title: Postdoc University of Delaware
Website: http://xtalsmgddp.wixsite.com/parasharlaboratory

Description:
Parashar laboratory at University of Delaware College of Health Sciences, is currently seeking a Postdoctoral Fellow to perform structure-function studies of proteins regulating bacterial signaling.

Qualifications:
• Ph.D. in Biochemistry, Molecular Biology, Structural Biology, or a related field
• Experience with cloning, protein expression, and protein purification methods
• A sound understanding of methods and approaches relating to macromolecular crystallography preferred
• Ability to plan and carry out research projects independently
• Ability to work on own initiative and take personal responsibility for delivery of work
• Excellent problem solving, interpersonal, communication and presentation skills
• A working knowledge of bacterial genetics and computational modeling of protein-ligand interactions preferred

Responsibilities include:
• Performing experiments for cloning, protein expression, and purification of proteins for biochemical and structural studies; robotic screens for crystallization; optimizing crystallization conditions; and collecting and analyzing diffraction data.
• Performing model building and structure refinement.
• Maintaining laboratory equipment to meet unique needs of the research activity
• Assisting with preparation of grant proposals, presentations and publications
• Actively seeking new collaborative projects within the department and externally

University of Delaware is well equipped with state-of-the-art equipment for molecular biology, protein purification, and crystallography, including crystallization robot, crystal imaging system, and X-ray generator. Please visit Parashar Laboratory website for more information. For consideration, please send your CV, list of three references and other relevant information to parashar@udel.edu with subject line "postdoctoral application"


[Post Date: January 09, 2019]

Title: Postdoc Case Western Reserve University
Website: https://case.edu/med/biochemistry/faculty/vandenakker.html

Description:
A postdoc position is immediately available at Case Western Reserve University in the structural biology lab of Dr. Focco van den Akker. The successful candidate will use structural biology and other approaches to uncover new therapeutic opportunities for developing antibiotics targeting the bacterial cell wall machinery. Bacterial proteins of interest are beta-lactamases, penicillin binding proteins, lytic transglycosylases, and others. For additional information, please see recent publications (Papp-Wallace et al. J. Med. Chem. 2018 10, 61, 4067-; Vijayaraghavan et al. PLoS One. 2018, 13, e0197136; van den Akker & Bonomo, 2018 Front. Microbiol., 9, 622) or the group website (https://case.edu/med/biochemistry/faculty/vandenakker.html).

This position is funded by NIH and other sources. This project is highly collaborative involving academic collaborators, several pharmaceutical companies, and clinician-researchers. In addition to protein crystallography, the project involves enzymatic structure-function studies, biophysical characterization for compound screening/testing, and drug design efforts.

Applications are solicited from highly motivated and creative individuals who can drive this multifaceted project. The applicant should have a Ph.D. and experience in either molecular biology or protein biochemistry (experience in protein crystallography and/or medicinal chemistry is not required but is desirable).

The position is open immediately and salary will be commensurate with qualifications and experience. Please send cover letter, CV, and contact information for three references to: focco.vandenakker@case.edu


[Post Date: January 07, 2019]

Title: Research Fellow IMCB Singapore

Description:
We are seeking an enthusiastic and self-motivated postdoctoral research fellow to study proteins involved in maintaining genome stability and the Hippo signaling pathway. We take a combinatorial approach of molecular biology, biochemical and biophysical methods, and structural biology (crystallography and cryo-EM). Significant aspects of our projects have translational potential. Candidates with an interest in the development of small molecules/peptides for cancer therapeutics are also welcome.

Singapore is an excellent environment to do research with many research groups close by in Biopolis [https://www.a-star.edu.sg/imcb]

Requirements:

· PhD in biochemistry, biophysics, molecular and cell biology or a related field

· Solid practical experience in Cryo-EM and/or X-ray crystallography

· Practical skills in molecular biology, protein expression (prefererally insect and/or mammalian cells) and purification, and various biochemical techniques

· Good publication record

· Competent in scientific writing

Interested applicants should send a CV, publication list, a brief description of research interests and experience, and three confidential letters of reference to: Prof. Haiwei Song, Email: haiwei@imcb.a-star.edu.sg


[Post Date: January 07, 2019]

Title: Postdoc University of Chicago
Website: www.thorntonlab.org

Description:
Postdoc position in evolutionary biochemistry, Thornton Lab, University of Chicago

We have an opening for a postdoc in protein evolution and functional molecular evolution. The lab’s goal is to characterize the evolutionary, genetic and biochemical mechanisms by which biological molecules acquired their present-day functions, structures, and biochemical properties. Most projects have combined computational approaches to reconstruct the historical trajectory of molecular evolution – particularly phylogenetics and ancestral sequence reconstruction – with detailed bench experiments to test hypotheses concerning the causes and consequences of those events. We also use high-throughput library-based methods and experimental evolution to characterize large ensembles of “might-have-been” histories from ancestral starting-points to better understand why evolution followed the path it took.

A variety of projects are available, depending on the candidate’s interests, and we encourage creativity in developing new projects. We have studied the evolution of transcription factors, enzymes, ligand-binding and scaffolding proteins, and molecular machines. We have been particularly interested in the evolution of molecular specificity, complexity, catalysis, multimerization, and allostery, and in the causes and consequences of epistasis and the distribution of effect-sizes in shaping proteins’ evolutionary processes.

We are a highly collegial group that draws scientists and students from a variety of disciplines – evolution, biochemistry, molecular biology, computational biology, genetics, biophysics, and more. The University of Chicago is a fantastic place to do science, especially at the interface of evolution and the molecular biosciences. Chicago is a great city rich in high and low culture; it is a hipster heaven and, in the summer, a fun beach town. People in the lab are fun, funny, interesting, mutually supportive, and humane.

More information about the lab is at http://www.thorntonlab.org. We strongly encourage applications from scientists who are women and members of groups underrepresented in science.

To apply, please email a single PDF containing a CV and brief research statement, including why you are interested in our lab, to me at joet1@uchicago.edu. The start date is flexible.


[Post Date: January 04, 2019]

Title: Postdoc Structural Biology Fred Hutch
Website: https://careers-fhcrc.icims.com/jobs/12660/

Description:
Post-Doctoral Research Fellow, Structural Biology

Job ID 12660
Type Regular Full-Time
Company Fred Hutchinson Cancer Research Center
Location US-WA-Seattle
Category Laboratory Research Sciences

Overview
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Stamatatos/Pancera lab, within the Vaccine and Infectious Disease Division, works towards the development of safe and effective vaccines against HIV-1 and malaria. Our major emphasis is the design of protein immunogens and understanding the immune response following vaccination or natural infection. The subgroup led by Dr. Pancera focuses on structural characterization of these immunogens and their immune responses. The laboratory utilizes a wide range of in vitro and in vivo systems and cutting-edge technologies and techniques. Experimental approaches include high-throughput crystallography, specialized immunological methodologies and assays, molecular and cellular biology techniques, bioinformatics, and computational approaches.

Our lab is seeking an outstanding Postdoctoral Fellow to work on a project involving the characterization of the humoral immune response following vaccination against HIV, malaria or other pathogens using X-ray crystallography and cryoEM and designs of novel immunogens.
Responsibilities

Perform recombinant protein expression (coli, insect cells, mammalian cells) and purification including affinity purification, ion exchange and FPL
Determine X-ray crystal structures of the proteins/antibodies complexes
Use Electron Microscopy for screening purposes (negative stain) and single particle cryoEM to determine the molecular structures of antigen-antibody complexes
Use of biophysical methods such as ITC and Bio Layer interferometry/SPR or ELISA
Initiate and carry out scientific projects under the supervision of Dr. Pancera
Develop and demonstrate a thorough understanding of the scientific literature relating to the research topics.
Conduct and publish research in HIV structural biology

Qualifications

PhD in Structural Biology, Protein Chemistry, Biochemistry or a related field is required with significant expertise in X-ray protein crystallography. Candidates with backgrounds in areas such as protein biochemistry, and vaccine development are strongly encouraged to apply. On-hands experience with diverse aspects of Molecular Biology is required. Experience in X-ray crystallography including up-to-date knowledge of relevant programs including CCP4, and Phenix packages, protein purification, protein characterization, and a strong publication history are strongly desired. Knowledge of cryoEM is not required but desirable. Additional expertise with tissue culture and immunological assays is a plus.


The candidate must be a ‘risk taker’, show initiative, willingness to take up new skills and responsibilities, and be a team player. Excellent attention to details and the ability to work independently are essential to success in this position, as are good communication and organizational skills. The candidate must be self-motivated, able to multitask and to work within a very collaborative environment. Salary will be commensurate with (appropriate) experience.
Our Commitment to Diversity
We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.


[Post Date: January 04, 2019]

Title: Director of Biological Discovery IPI
Website: https://proteininnovation.org/

Description:
Institute for Protein Innovation (IPI) Director of Biological Discovery

Employer: Institute for Protein Innovation
Location: Boston, Massachusetts (US)
Salary: Salary will be competitive.
Discipline: Life Sciences, Biochemistry, Biophysics, Immunology, Structural Biology
Position Type: Full Time
Organization Type: Non-Profit
Job Type: Faculty, Group Leader/Principal Investigator

The Institute for Protein Innovation (IPI) seeks a Director of Biological Discovery to lead our target selection and biological validation programs. The IPI, a 501(c)(3) nonprofit organization embedded within the Harvard Medical School Longwood Area, has established itself as a premier center for protein science and has implemented state-of-the-art automation for high-throughput antibody discovery.

The longterm mission of the IPI is the discovery of antibodies targeting all secreted and cell surface proteins from human and mouse to serve as both tool compounds and leads for potential new therapeutics. To maximize biological and therapeutic impact, the IPI has adopted a strategy that includes the targeting of functionally related groups of protein families, such as those that participate in stem cell signaling, specifying neuronal synapses, or regulating immune responses.

The Director of Biological Discovery will take a lead role in target selection, including identifying areas of biological importance, as well as detailed antigen design to maximize production of antibodies that modulate biological processes. Exceptional communication and organizational skills are critical, as the Director will be responsible for the organization and oversight of community-based workshops in which IPI-generated antibodies are distributed to community members for expert validation, evaluation in cell-based and animal-based models, and dissemination in publications.

This position offers a unique opportunity to straddle academics and therapeutics, with enormous prospects for discovery and intellectual property generation. Candidates should hold a PhD (or equivalent degree) and have at least three years of postdoctoral experience, with demonstrated expertise in structural immunology, structural neurobiology, sequence-based assessment of biological function, or a related field.

The Director of Biological Discovery has the opportunity to receive a part-time academic appointment as Assistant Professor at Boston Children’s Hospital and Harvard Medical School. This joint appointment affords the opportunity to participate in teaching activities, with enhanced opportunities for intimate collaborations with the exceptional scientific community within and surrounding Harvard Medical School.

Interested candidates should send a CV and a brief statement of future research interests as a single PDF to careers@proteininnovation.org, and arrange for three letters of reference be sent to the same address. Please include “CCP420181227” in the subject line.

IPI offers competitive compensation and benefits, including health and dental insurance, generous vacation and holiday time off, and retirement saving plans. IPI is an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability.


About the Institute
IPI is a nonprofit research organization whose mission is to foster innovation in protein research, train the next generation of innovators and entrepreneurs in protein science, forge new ties between academic and industry investigators, and bridge the missing link between genomics and therapeutics. IPI has built a high-throughput antibody discovery platform for developing opensource antibodies targeting the entire human extracellular proteome. This resource will produce critical tools, lead therapeutics, and technologies that empower academic and industry scientists, catalyze entrepreneurship, and accelerate drug discovery.


[Post Date: December 29, 2018]

Title: Postdoc Michigan State University
Website: http://careers.msu.edu/cw/en-us/job/500578/research-associatefixed-term

Description:
One NIH funded Research Associate (postdoctoral) position is available immediately in the laboratory of Prof. Erik Martinez-Hackert at Michigan State University in East Lansing, Michigan.

We seek a highly motivated individual with a strong interest in integrated approaches to investigate mammalian cell-signaling problems. Specifically, the hire will study the molecular and biological functions of TGF-beta family growth factors, their receptors and co-receptors, focusing on a structure-function understanding of extracellular protein-protein interactions. The lab combines X-ray crystallography, SPR and other biophysical techniques with functional in vitro and in vivo readouts. Significant aspects of our projects have translational potential. The lab is to also planning to take projects into CryoEM in the near future.

The hire should have a PhD and at least 1 first author publication from his/her doctoral work. In addition, the hire should have significant experience in three of the four following disciplines: molecular biology, protein expression and protein purification, X-ray crystallography/structural biology and/or tissue culture. The hired individual will be exposed to approaches and ideas that will prepare him/her well for either academic or industry careers. Our projects are well developed and feasible.

For questions, please contact me at emh@msu.edu.

To apply, please follow the link above.


[Post Date: December 29, 2018]

Title: Postdoc University of Illinois at Chicago

Description:
We have an immediate opening for a talented, highly motivated postdoctoral scholar in my laboratory at the University of Illinois located in downtown Chicago, IL (USA) to study the structure and function of the ribosome (https://bios.uic.edu/bios/people/faculty/yury-polikanov).

The research in our laboratory is focused on understanding basic principles of protein synthesis in bacteria, the modes of action of ribosome-targeting antibiotics, and mechanisms of drug resistance at a structural level. The successful candidate will be specifically involved in determination of high-resolution structures of ribosome functional complexes using macromolecular X-ray crystallography techniques.

Basic qualifications:
• PhD in chemistry, biochemistry, biophysics, or a related field;
• Practical skills in molecular biology, protein expression, purification, and various biochemical techniques;
• Experience in structural biology (cryo-EM or X-ray crystallography);
The successful candidate is also expected to:
• Drive forward the projects;
• Act independently or semi-independently in terms of planning and executing the experiments;
• Compile, analyze, and prepare data for publications;
• Assist with training of graduate and undergraduate students.
Review of applications will begin immediately and will continue until the position is filled. Interested applicants should send their CV along with a cover letter briefly describing their research accomplishments, current research interests and contact information for three references directly to Dr. Yury Polikanov, yuryp@uic.edu.


[Post Date: December 21, 2018]

Title: Postdoc University of Birmingham
Website: https://bit.ly/2EET1ta

Description:
A Wellcome-Trust postdoctoral position (for 2 years, possibly extendible to 4) is open in the Lovering laboratory, using x-ray crystallography to study the means by which predatory bacteria can form a pore in the prey outer membrane.

More information on the lab can be found here: https://www.birmingham.ac.uk/staff/profiles/biosciences/lovering-andrew.aspx


[Post Date: December 20, 2018]

Title: Postdoc Fellows Institute for Protein Innovation

Description:
Postdoctoral Fellows (Innovation, Discovery, & Entrepreneurial)

Employer: Institute for Protein Innovation
Location: Boston, Massachusetts (US)
Salary: $50,000-$70,000
Discipline: Life Sciences, Biochemistry, Bioengineering, Biomedical Engineering, Biophysics, Biotechnology, Computational Biology, Immunology, Proteomics, Structural Biology, Health Sciences, Drug Discovery
Position Type: Full Time
Organization Type: NonProfit
Job Type: Postdoc, Postdoc Fellowship

Institute for Protein Innovation (IPI) aims to equip the next generation of scientist-entrepreneurs with the skills and knowledge to ensure successful careers as academics, industrial scientists, and entrepreneurs. We are looking for highly motivated, scientifically curious, and intellectually creative candidates to train as Innovation Postdoctoral Fellows, Discovery Postdoctoral Fellows, and Entrepreneurial Fellows.

Innovation Postdoctoral Fellows.
Innovation Fellows will work with Platform leaders and affiliated IPI faculty to develop novel technologies, platforms, and approaches in protein science. Examples include improving antibody discovery platforms, engineering novel properties into proteins, developing new methods for identifying receptor-ligand pairs, and creating novel platforms for protein expression or drug discovery. Research must be fully publishable.

Discovery Postdoctoral Fellows. Discovery Fellows will work with Platform leaders and affiliated IPI faculty to use IPI platforms for discovery of new biological principles. Examples include discovery of new biological pathways or interactions, antibodies to target proteins for which good reagents are not currently available that enable discovering novel functional properties, partners of target proteins, and potential lead therapeutics. Research must be fully publishable.

Entrepreneurial Fellows. Successful Innovation or Discovery Postdoctoral Fellows can transition to Entrepreneurial Fellows. The purpose of these fellowships is to allow technical innovations or discoveries to be developed sufficiently to enable a career in Academia, patents, or company formation.

Qualifications:
• Ph.D. in Biochemistry, Biophysics, Engineering or related field
• Demonstrated track record of publications and productivity
Please send applications to careers[@]proteininnovation.org. Applications should include: a cover letter, CV/resume, list of three references, and “CCP420181219” in the subject line.

IPI offers competitive compensation and benefits, including health and dental insurance, generous vacation and holiday time off, and retirement saving plans. IPI is an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability.


About the Institute
IPI is a nonprofit research organization whose mission is to foster innovation in protein research, train the next generation of innovators and entrepreneurs in protein science, forge new ties between academic and industry investigators, and bridge the missing link between genomics and therapeutics. IPI has built a high-throughput antibody discovery platform for developing open-source antibodies targeting the entire human extracellular proteome. This resource will produce critical tools, lead therapeutics, and technologies that empower academic and industry scientists, catalyze entrepreneurship, and accelerate drug discovery.

For more information about IPI: proteininnovation.org.


[Post Date: December 19, 2018]

Title: Postdoc Ohio State University

Description:
The Nakanishi lab is looking for a self-motivated structural biologist interested in elucidating the molecular mechanisms of diversified RNA silencing by human Argonaute proteins and their binding partners. The position is available immediately and will remain open until filled.

MicroRNAs and other small RNAs are loaded into different Argonaute proteins to form unique effector complexes, regulating many biological processes. Humans have four Argonaute paralogs, each of which is responsible for specialized roles. Our focus is to understand the molecular bases for their unique RNA silencing. To this end, we take a combinatorial approach of molecular biology, biochemical and biophysical methods, and structural biology (crystallography and cryo-EM). Candidates should have a strong background and expertise in X-ray crystallography or single-particle electron microscopy and the biochemical experiments. Applicants with experience in RNA biology will be stronger candidates. New Ph.D. graduates are encouraged to apply.

My group has a great environment to pursue goals. We own multiple AKTA FPLC systems and an automatic crystal plate imaging system. We have access to OSU Campus Chemical Instrument Center in the same building that has a crystallization robot (Mosquito) and a laboratory-scale X-ray diffractometer (Rigaku MicroMax-003 with a Pilatus 200K detector). We remotely carry out our crystallographic experiments at The Advanced Photon Source. The Ohio State University has a state-of-the-art cryo-EM facility, CEMAS (URL: https://cemas.osu.edu), that is located within a 5 min driving distance from my lab. There is a Titan Krios with a K3 Bioquantum direct electron detector, imaging phase plates, STEM/TEM tomography, and an image spherical aberration corrector.

Interested candidates should email a cover letter describing their research experience, a curriculum vitae, and the names of three references (one should be the current supervisor) to nakanishi.9@osu.edu.


[Post Date: December 19, 2018]

Title: Senior Research Fellowship
Website: https://www.nature.com/naturecareers/job?id=669251

Description:
We have a 4-year Senior Research Fellowship open within our newly developing Centre of Enzyme Innovation (CEI) at the University of Portsmouth, UK. We are looking for a talented structural biologist with an interest in the characterisation of enzymes and their modification for improved function through protein engineering. We are focused on biological catalysts for the depolymerisation of polymers from natural (eg. lignocellulose) and synthetic (plastics such as PET) sources.

Publications from our group this year include our work on PETase (https://www.pnas.org/content/115/19/E4350) and a new class of cytochrome P450 for the bioconvertion of lignin (https://www.nature.com/articles/s41467-018-04878-2).

The salary range is £39-48k (up to $60k USD) and the closing date for applications is at the end of January.


[Post Date: December 19, 2018]

Title: Postdoc UCLA

Description:
A NIH-funded post-doctoral position is available in my group at UCLA to study the structure, mechanisms, and functions of membrane protein complexes involved in protein or phospholipid trafficking in eukaryotic pathogens (such as fungi and parasitic protozoa) as described in AhYoung, Jiang et al. in PNAS 2015 (doi: 10.1073/pnas.1422363112) and Ho, Beck et al. in Nature 2018 (doi: 10.1038/s41586-018-0469-4).

Motivated and qualified candidates should hold a PhD in the field of structural biology and be proficient in cloning, protein purification, and structure solving by either crystallography or cryo-electron microscopy. Experience with expression in insect cells and/or HEK293 cells is strongly preferred.

Applicants should address their CV, a cover letter stating their accomplishments, interests, and career plans together with the addresses of three potential references to pegea@mednet.ucla.edu.


[Post Date: December 18, 2018]

Title: Postdoc JGU/IMB Mainz, Germany

Description:
Postdoc position in Structural Biology at JGU/IMB Mainz, Germany
A postdoc position is available in the group of Eva Wolf at the Johannes Gutenberg University (JGU)
and the Institute of Molecular Biology (IMB) in Mainz, Germany. The position is available for a period
of 4 years. Salary will be according to German public service payment agreement (TV-L 13; 100%).
Research in the Wolf group is focused on the structural, biochemical and biophysical analysis of
protein complexes involved in circadian clocks (e.g. Czarna et al, Cell 2013; Schmalen et al, Cell
2014) and in their interconnection to genome maintenance, specifically via the protein Timeless.
Following up on our Cryo-EM structure of a mammalian Timeless–Tipin-RPA complex (Witosch et al,
NAR 2014), this project aims at 3D-structures of Timeless complexes with replication fork associated
proteins and their subsequent biological validation, e.g. in mutational studies. It will involve a wide
range of techniques including recombinant protein expression (E.coli, insect cells), protein purification,
Cryo-EM, X-ray crystallography as well as complementary biochemical, biophysical and cell-based
methods to study protein interactions and activities.
The successful postdoc candidate will have solid practical experience in Cryo-EM and/or X-ray
crystallography, in recombinant protein expression (preferentially insect cells and E.coli) and in protein
purification (preferentially purification of protein complexes). Additional practical experience with
biochemical and quantitative biophysical analyses of protein interactions is an advantage. She/he will
hold a PhD in a relevant discipline and be fluent in English (written and spoken).
The Wolf group is currently located at the Institute of Molecular Biology (IMB, www.imb.de).
IMB is a center for basic research, which is generously funded by the Boehringer Ingelheim Foundation
and the state of Rhineland-Palatinate and is located on the campus of Mainz University, Germany.
To apply, please send a single PDF file containing your cover letter stating research interests and
expertise, a CV, scanned certificates and contact details of at least two references to
sek-ew@uni-mainz.de before January 29th 2019. Informal enquires should be addressed to
Eva Wolf (evawolf1@uni-mainz.de). The additional application to the IMB Postdoc Programme
(IPPro, postdoc@imb.de, www.imb.de/postdocs) is encouraged.


[Post Date: December 18, 2018]

Title: Postdoc Purdue University

Description:
A position is available for a highly qualified and motivated postdoc with a strong background in Molecular/Cell Biology or Immunology. The successful applicant will be responsible for conducting research aimed at identifying and characterizing new drug targets for treatment of important human diseases. Activities may involve i) expressing and characterizing proteins that are upregulated in various disease states, ii) cloning, mutating, expressing and developing assays for studying functional aspects of the target proteins, iii) immunofluorescent staining of tissue sections from diseased tissues, iv) shRNA knockdown of desired proteins in cultured cells, and v) immunoblotting and other common biochemical assays. Management of day-to-day research goals and priorities, supervision of graduate students assigned to the same project, and mentoring of other research personnel regarding the design and execution of specific research methods/approaches may also be required.

The lab is directed by Professor Philip S. Low in the new Drug Discovery Institute on the West Lafayette Campus of Purdue University. Other members of the lab are involved in designing new therapies for cancer, fibrotic diseases, infectious diseases, sickle cell disease, bone fractures and related pathologies, and autoimmune diseases, etc. Participation in some of these existing projects may also be required.

Please send CV and list of three names of potential referees to:

Philip S. Low
Presidential Scholar for Drug Discovery
Ralph C. Corley Distinguished Professor
Department of Chemistry
Purdue University
720 Clinic Dr.
West Lafayette, IN 47907
Email: plow@purdue.edu


[Post Date: December 17, 2018]

Title: Senior Scientist Evotec USA
Website: https://www.ziprecruiter.com/jobs/evotec-473c889a/senior-scientist-protein-purification-structural-biology-f3e5dcbf

Description:
Due to continued expansion, there is an opportunity to join the Structural Biology team at Evotec (US) based at Princeton, New Jersey, as a Senior Scientist (Structural Biology).

Please see the advert in the link. Interested candidates should apply directly through Zip Recruiter.



[Post Date: December 17, 2018]

Title: La Technician NIH

Description:
The Roll-Mecak lab at the National Institutes of Health has an opening for a lab technician to work on protein expression in human and SF9 cells as well as work under the mentorship of a postdoc on projects related to structural biology of microtubule regulators. Basic skills in molecular biology are required. Experience with tissue culture is preferred but not required.

Our lab is a dynamic and very friendly group. The position is perfect for someone that has an enthusiasm to learn and loves scientific research. You will also benefit from the vibrant academic environment and terrific research resources that NIH offers.

The job is full-time and located at the NIH Bethesda main campus, Maryland, which is only 20 min to the DC downtown area by metro. Please visit our lab website for more information. ( https://neuroscience.nih.gov/ninds/rm_lab/)

Requirements for the position,
1. The candidate should have a B.S. degree in Biology, Biochemistry or other related areas.
2. At least 1 year of lab experience in one of these areas: molecular biology, tissue culture or biochemistry.

Please contact Jiayi Chen (jiayi.chen@nih.gov) with your CV and names of three referees if you are interested in the position.


[Post Date: December 17, 2018]

Title: Positions at Astex, Cambridge, United Kingdom
Website: http://astx.com/our-people-and-culture/current-uk-openings/

Description:
We have a number of positions available in our Molecular Sciences group at Astex Pharmaceuticals, Cambridge UK to help us continue to develop and expand our structural biology and cryo-EM efforts

Further details of these and other roles can be found at the web site link.

Informal inquiries are welcome (pamela.williams@astx.com)

The deadline for applications is 31st January, 2019


[Post Date: December 17, 2018]

Title: Postdoc Umeå University, Sweden
Website: https://www.biostruct.umu.se/principal-investigators/ronnie-berntsson/

Description:
Postdoctoral fellowships to study Type 4 Secretion System

The Berntsson lab at the department of Medical Biochemistry and Biophysics at Umeå University, Sweden, is looking to recruit up to two postdoctoral fellows (2-year projects) to study the structural and functional aspects of Type 4 Secretion Systems. These large protein complexes are responsible for horizontal gene transfer between bacteria. As such, they facilitate the spread of, among other genes, antibiotic resistance between bacteria, both intra- and interspecies.
The overall goals of these particular projects are to continue the structural and functional characterisation, already begun in the lab, of the i) the adhesion proteins and ii) the DNA processing proteins of G+ Type 4 Secretion Systems. The projects will involve molecular biology, biochemistry and structural biology techniques, with an early emphasis on the functional characterization of these proteins and their complexes.

Qualifications
The applicants must possess a PhD, or another diploma deemed equivalent to a PhD, within molecular biology, biochemistry, structural biology or a related field. Furthermore, the applicant shall have practical experience and expertise of cloning and protein production and purification in bacteria. The applicant should preferably be experienced with functional studies of (membrane) proteins using various molecular biology and biochemical methods, such as ITC, SPR, fluorescence spectroscopy and microscopy, as well as having experience with protein crystallography. Previous experience of working with membrane proteins is an advantage, as is previous experience of fluorescence microscopy and electron microscopy. The applicants must have a very good level of English, both written and spoken. The applicants are also expected to be good team players, but should also be able to work independently.

Application
The application should consist of the following:
1. A short (maximum 1 A4 page) cover letter, explaining the motivation to apply for the position.
2. The Curriculum Vitae of the applicant, including a list of published peer-reviewed articles.
3. Copies of the PhD diploma (or equivalent).

4. Contact details for three references, of which one should be your PhD supervisor.

The duration of the fellowship is 2 years. Your application should be written in English and prepared as a package in PDF format, to be submitted to ronnie.berntsson@umu.se. Make sure to use the subject line: “postdoc application T4SS” in the application email. Submit the application on January 15, 2019 at the latest. The top ranked candidates will be contacted within three weeks from the closing date for an interview. Starting date according to agreement. For more information, contact Dr. Ronnie Berntsson.



[Post Date: December 17, 2018]

Title: 2 Postdoc Positions
Website: http://careers.pageuppeople.com/756/cw/en-us/job/510945/univ-postdoctoral-scholar-biochemistry-molecular-biology

Description:
My laboratory is seeking to fill two postdoctoral positions that are immediately available for highly motivated biochemists/structural biologists interested in studying molecular mechanisms of signaling by ubiquitin and ubiquitin-like proteins.

Posttranslational modification of proteins by ubiquitin and ubiquitin-like modifiers occurs through the sequential activities of a cascade of enzymes and a major focus of the laboratory is to understand the structural basis by which this enzymatic machinery functions. We address these issues using a multidisciplinary approach that combines X-ray crystallography, biochemical/biophysical techniques, and cell-based studies. Candidates should hold a PhD in a relevant field with demonstrated expertise in X-ray crystallography and/or the biochemical analysis of protein ubiquitination.

MUSC is well-equipped for all aspects of X-ray crystallography, including institutional membership of the SER-CAT facility at the Advanced Photon Source. We have a vibrant and growing program in structural biology and work in a highly collaborative environment. The University is located in historic Charleston, SC where the weather is beautiful year-round. There are several beaches within minutes of the city and the mountains are only three hours away. In addition to these amenities, the art, history, food, and festivals make Charleston a fantastic place to work and live.

Interested candidates should e-mail a cover letter, CV, and the names of three references to olsensk@musc.edu and apply online at http://careers.pageuppeople.com/756/cw/en-us/job/510945/univ-postdoctoral-scholar-biochemistry-molecular-biology.

The positions will remain open until filled.


[Post Date: December 12, 2018]
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