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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Postdoc


Postdoctoral position – Towards deciphering mechanisms of transcriptional and post-transcriptional gene regulation in eukaryotic cells

We are looking for highly motivated postdoctoral scientist with an interest in gene regulation. The proposed projects will utilize state-of-the-art biochemistry and structural approaches combined with the functional genome-wide analysis to understand how transcription factors and chromatin modifiers regulate transcription of protein-coding and non-coding genes in yeast and mammalian cells. The structural study will be done as a part of existing productive collaboration with Jonathan Grimes laboratory at STRUBi (Oxford) (Wittmann et al., 2017 Nature Communication, in press). Candidates trained in protein purification, RNA analysis, and mammalian cell culture are encouraged to apply. Basic knowledge of bioinformatics is beneficial. Applicants should have or will shortly obtain a PhD and are expected to be highly motivated, have at least one first authorship publication, show excellent critical thinking and good communication skills and have the ability to work as part of a team.

Interested applicant should contact Dr Lidia Vasiljeva directly:

Dr. Lidia Vasiljeva: lidia.vasilieva@bioch.ox.ac.uk
Lab web site: http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=675

[Post Date: March 23, 2017]

Title: Postdoc

A three-year postdoctoral position for a biochemist/structural biologist is available in the Department of Biochemistry, University of Cambridge, England. The Department has state-of-the-art equipment and facilities, including crystallization robots, NMR, cryo-EM, biophysics, metabolomics, and easy access to synchrotron beamlines and confocal microscopy. The postdoctoral position is available immediately with Dr Monique Gangloff following a New Investigator Research Grant award to study mosquito vector innate immunity.

We are looking for a highly motivated postdoctoral Fellow with a strong interest in Structural Biology, Signalling and Vector Biology. The project investigates the structure and function of mosquito immune receptors that have diverged and undergone gene duplication under the influence of selective pressure by pathogenic parasites and viruses, potentially acquiring new functions relating to host-pathogen homeostasis.

You will gain in-depth experience in Structural Biology by determining receptor-ligand complex structures using either X-ray crystallography or complementary techniques such as Small Angle X-ray Scattering (SAXS) and high-resolution cryo-EM. You will establish cell-based assays to verify predicted structure-function relationships. It is expected that you present your results at scientific conferences and write/publish scientific papers in high-quality, peer-reviewed journals.

Essential requirements:
• PhD in biochemistry, molecular and cellular biology, or related disciplines
• Strong background in construct design, molecular biology and protein purification
• Significant experience with biophysical and structural techniques
• Strong organizational and interpersonal skills
• A proven record of work published in reputable scientific journals.
Desirable requirements:
• Experience of protein expression methods using prokaryotic and eukaryotic in particular insect cell expression systems
• Proficiency in cell-based signaling assays to establish novel luciferase reporter assays in mosquito cell lines
• Knowledge in ligand fishing experiments using Mass Spectrometry
• Experience of working with Protein Crystallization, X-ray crystallography, SAXS, cryo-EM, Isothermal Titration Calorimetry and Surface Plasmon Resonance.

To apply online for this vacancy, please visit http://www.jobs.cam.ac.uk/job/13256/ then click on the 'Apply' button. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

The application should include a cover letter describing the candidate's research interests and motivation to apply, the CV and list of publications, and contact details of three referees.

Any enquires regarding the application process can be directed to Adriana Dote (personnel@bioc.cam.ac.uk).

Informal enquiries are welcome and can be made to Dr. Monique Gangloff (mg308@cam.ac.uk).

Please quote reference PH11763 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

[Post Date: March 23, 2017]

Title: Associate Research Scientist
Website: http://tinyurl.com/lslvlh4

Associate Research Scientist (Job Number: 1701159)

Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. And driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

As a key member of the Molecular Structure & Design group, the successful candidate will be responsible for crystallization, purification and biophysical characterization of recombinant proteins using knowledge of conventional and affinity chromatography methods, gel electrophoresis, crystallization, and general laboratory procedures. As a member of a team involved in the early stages of discovery, the position requires close collaboration with molecular biologists, protein scientists and structural biologists as well as scientists working in the various disease biology and translational areas within preclinical research. The candidate must be self-motivated, possess excellent communication skills, and work both independently as well as in teams. Personal attributes of integrity and scientific creativity are required.


- BS/MS in Biochemistry, Structural Biology or related field required
- 2-5 years experience required
- Carry out protein crystallization experiments, crystallization optimization, crystal harvesting for proteins, protein-ligand complexes, and protein-protein complexes and X-ray data collection.
- Use crystallization automation equipment (liquid handlers, drop setters, imagers, etc.)
- Carry out protein purification / biophysical characterization as well as thoroughly understands protein chromatography principles.
- Capable of independently designing experiments, generating data and interpreting results; demonstrated ability to work in a team environment.
- Possesses strong communication skills – be a good listener, have strong, concise, and consistent written and oral communication skills.

Bristol-Myers Squibb is an equal opportunity employer - Vet/Disability.

Apply here:

[Post Date: March 22, 2017]

Title: Research Fellow

We are seeking an enthusiastic and self-motivated postdoctoral research fellow to work on structural and functional analysis of proteins involved in RNA metabolism and the Hippo signalling pathway. The applicants should have a background in structural biology, biophysics, biochemistry or a related field with a strong publication record. Candidates with experiences in structure determination by cryo-electron microscopy or in protein expression using insect/mammalian cells are preferred. Please send CV, including the names and addresses of three references to:

Prof. Haiwei Song
Institute of Molecular and Cell Biology
61 Biopolis Drive
Singapore 138673

[Post Date: March 21, 2017]

Title: Research Assistant

A research assistant position is available immediately at the BioMedX Innovation Center in Heidelberg, Germany. The ideal candidate ought to have a background in protein biochemistry or microbiology, although other biological fields are not deal breakers. Local candidates will be given preference. Please send applications to avvaru@bio.mx More information on the position is available at http://apply.bio.mx/job/2017-J08

[Post Date: March 17, 2017]

Title: Postdoc

Applications are invited for postdoctoral positions in my lab at Cold Spring Harbor Laboratory to work on the structure and mechanism of gene silencing pathways or DNA replication.

Please see our web page for more details (http://joshua-torlab.labsites.cshl.edu/).

Positions are available for highly motivated, outstanding applicants with a recent PhD and experience in electron microscopy, protein crystallography, or a related field, or applicants with experience in biochemistry and molecular biology with a keen interest in structural biology.

We are about to take delivery of a Titan Krios cryo electron microscope. Combined with the nearby NSLS-II coming on line, these are exciting times with exciting capabilities.

Cold Spring Harbor Laboratory (CSHL) provides a unique, stimulating and very collaborative environment for scientific interactions. Located on the North Shore of Long Island, CSHL is in a beautiful setting and is a wonderful place to expand one’s knowledge of biology in many different areas, particularly via CSHL’s internationally acclaimed Meetings and Conferences, which our postdocs can freely attend. For details about CSHL please see our web site at: http://www.cshl.edu/

Please send CV, list of publications, a summary of research experience and interests, and contact information of three references.

[Post Date: March 17, 2017]

Title: Postdoc

A 2-years fellowship founded by Fondazione Cariplo is available for a postdoc position at the Biochemistry and Structural Biology Unit of the Department of Pharmaceutical Sciences (DSF) of University of Piemonte Orientale in Novara, Italy (http://www.dsf.uniupo.it).

The Department of Pharmaceutical Sciences research activities focus on the discovery and development of new bioactive compounds and the improvement of their formulation and delivery. The Department comprises a wide range of expertise and resources including pharmacology, chemistry, bioinformatics and drug delivery technologies in a highly motivating interdisciplinary environment.

We are seeking a strongly motivated candidate with skills in biochemistry/enzymology and structural biology to carry out a research program aimed at understanding the molecular aspects of Mycobacterium tuberculosis DNA repair to disclose its role in the pathogenesis of tuberculosis in humans. In particular, the postdoc will work on the structural and biochemical characterization of recombinant proteins that are key players in M. tuberculosis DNA repair machineries.
For the recruitment process, we require highly motivated candidates to send a curriculum vitae and the name of one-two Referents within April 15th 2017 to:

Prof. Menico Rizzi (Head of DSF Biochemistry/Structural Biology Unit)
Ph: +39 0321 375712
email: menico.rizzi@uniupo.it


Dr. Riccardo Miggiano (Referent of the scientific program)
Ph: +39 0321 375715
email: riccardo.miggiano@uniupo.it

[Post Date: March 16, 2017]

Title: Postdoc

Postdoctoral Research Opportunities in Infection Biology and Molecular Infection Medicine at Umeå University, Sweden (two projects in structural biology).

UCMR- Umeå Centre for Microbial Research, Sweden has six post-doc positions available.

For more details, see:



Note: The recruitment is a two-step process: First, the candidates must provide all relevant documents as described in the advertisement. Secondly, selected applicants will be asked to provide a two-page research plan linked to a research group.
The two proposed research projects in structural biology are: “Deciphering the assembly mechanisms of bacterial fimbriae: structure, assembly and function” (http://www.chemistry.umu.se/forskning/group-leaders/karina-persson) and “Crystallographic Studies of RNA-thermosensors in bacterial pathogens” (http://www.chemistry.umu.se/forskning/group-leaders/elisabeth-sauer-eriksson).

Interested qualified candidates are encouraged to contact one of the corresponding group leaders as soon as possible.

Contact for the bacterial fimbriae project: Karina Persson (karina.persson@umu.se)

Contact for the RNA-thermosensor project: Elisabeth Sauer-Eriksson (elisabeth.sauer-eriksson@umu.se)

[Post Date: March 16, 2017]

Title: Structural Biologist

We are recruiting a structural biologist at senior/postdoctoral level, to join the metabolic research team at the SGC University of Oxford, led by Assoc Prof Wyatt Yue.

You will be part of a dynamic and focused team, elucidating the molecular mechanism and small molecule therapy for the causative gene products of common (e.g. diabetes, obesity, endocrinology) and rare (e.g. inborn errors of metabolism) disorders.

• You have a PhD in structural biology/biochemistry
• You have experience in structure-based drug discovery
• You have interest in the field of metabolic diseases
• You are a self-starter, team player and completer/finisher who enjoys a challenge

Interested applicants please refer to job description and apply online via the page (Vacancy ID: 127848):

Closing date: 12.00 midday (UK) on Thursday 13 April 2017

[Post Date: March 15, 2017]

Title: Postdoc

Details below for a postdoctoral position now open with the SIBYLS group at the Advanced Light Source as part of a collaborative project between Lawrence Berkeley National Laboratory (LBNL) and the National Cancer Institute (NCI).
Please Email Jane Tanamachi (jtanamachi@lbl.gov) for more information or questions.

Are you looking to apply your skills in Integrative Structural Biology to the development of new approaches to explore organization of functional bacterial chromosome? The SIBYLS Group at Lawrence Berkeley National Laboratory is seeking a Postdoctoral Fellow in the field of Integrative Structural Biology. The SIBYLS group utilizes a multidisciplinary approach to study the structures and functional mechanisms of large macromolecular assemblies in promoting chromatin reorganization and transcriptional regulation. Our long-term goal is to modulate the functions of important DNA control elements and regulatory proteins or RNA’s for the prevention and treatment of various microbial infections or cancers. SIBYLS is also a world class synchrotron resource for structural biologists located at the Advanced Light Source, Lawrence Berkeley National Lab. SIBYLS scientists maintain productive research programs in chromatin remodeling, DNA damage responses, and genome stability. In addition, SIBYLS staff has excellent access and exposure to unique facilities, including the National Center for X-ray Tomography, the Joint Genome Institute sequencing facility, and the Molecular Foundry nanoscience facility. The SIBYLS group also has strong interactions with its neighbor, the University of California Berkeley, providing an unmatched research environment that combines a world-class academic research environment with unique national user facilities.

Essential:Under the general supervision of Dr. Michal Hammel (LBNL) perform research including molecular and biophysical analyses of nucleoprotein assemblies in vitro and cellular imaging at the mesoscale. Approaches to be used include: (1) Soft X-ray tomography at the cell level (2) Static and time-resolved studies by small angle X-ray scattering (SAXS) at the nanoscale level (3) Crystallographic studies at the atomic scale (4) Integration of crystallographic structures, solution data and cell imaging to obtain biologically relevant structures (5) Biochemical and biophysical assays of complexes to define conditions that affect their assembly and activities. (6) In the collaboration with Dr. Sankar Adhya (NCI) integrate results from specialized cellular biology techniques.

Candidates for postdoctoral positions should:
• Hold or will have a Ph.D. degree in biophysics, bioinformatics, biochemistry or cell biology
• Passionate about using structural data to influence key scientific decisions
• Strong hands-on skills in molecular biology and protein biochemistry
• Proven ability to write own scripts in Linux environment and to utilize cheminformatics tools
• Broad knowledge in protein characterization, biophysics and bioinformatics with experience in homology modeling and simulation will be helpful to drive projects forward
• Outstanding candidates with different skill sets will be taken into consideration, spanning from structural biologists with experience in structural biology to cell biologists.
• Experiences in SAXS, SXT or Cryo-EM preferred but not mandatory

Period: one year position with possibility of renewal


[Post Date: March 14, 2017]

Title: Postdoc University of Liverpool



£32,958 - £34,956 pa

An exciting opportunity has emerged in the Molecular Biophysics group to work on a BBSRC-supported project on structure-function-mechanism studies of Cu-nitrite reductase and membrane bound nitric oxide (NO) reductase and the role of metabolon complex formation in controlling levels of cytotoxic NO. The project will link crystallographic studies with techniques to probe factors that control delivery of electrons and protons to the active site of these enzymes. You will be responsible for using established molecular biology procedures underpinning the overexpression and purification of a number of enzymes and their mutants including membrane proteins and undertake crystallographic, spectroscopic and mechanistic aspects of the programme. You will have the opportunity to spend up to 4 weeks in the RIKEN laboratories in Japan as part of a collaborative programme alongside two PhD students working on membrane-bound nitric oxide reductases. You should have a PhD in the area of physics, chemistry, biological sciences or biophysics, with experience in protein crystallography and practical knowledge of molecular biology preferably with experience in membrane proteins. Excellent verbal and written communication skills are essential. The post is available for 2 years and the ability to commence immediately would be advantageous.

Job Ref: 006744 Closing Date: 11 April 2017

For full details and to apply online, please visit: https://recruit.liverpool.ac.uk

[Post Date: March 10, 2017]

Title: Postdoc

A NIH funded postdoctoral fellow position for CryoEM and/or protein crystallography is available immediately in Dr. Xu’s laboratory at the Department of Molecular and Structural Biochemistry at North Carolina State University. Research in Xu lab focuses on structural elucidation of protein kinase activation in cellular signal transduction. This is a high risk, high impact research project encompassing an interdisciplinary approach to tackle the underlying questions that includes CryoEM, X-ray crystallography, biochemistry, biophysics, cell biology and in vivo analyses.

Candidates should be motivated to work independently and should demonstrate healthy team work ethic. The selected postdoc will have the opportunity to conduct research in a truly interdisciplinary setting with close interactions with Biochemistry, Molecular biology and Structural biology groups.

Candidates with expertise in at least the following areas are invited to apply:

- Experience in working with CryoEM or X-ray crystallography is required.
- Extensive experience in molecular cloning and protein purification is preferred.

In addition, candidate is required to demonstrate excellent written and verbal communication skills.

Interested candidates should email their full CV and a list of three references.

NC State University (NCSU) is one of the prestigious public universities in US. It is located at the center of North Carolina’s Research Triangle Area, which has multiple research, medicinal, healthcare institutes and biomedical industries. There are ample career opportunities in Biotechnology and medicine. In addition, research triangle area is one of the best places in US for living. Raleigh-Durham area has a lower living cost compared to other big cities. However, quality of living, education, healthcare is among one of the best in the nation.

Contact information:

Guozhou Xu, PhD
Assistant professor of Biochemistry
Department of Molecular and Structural Biochemistry North Carolina State University Raleigh, NC 27695-7622

E-mail: gxu3@ncsu.edu

[Post Date: March 08, 2017]

Title: Postdoc Research Associate

Imperial College London
Department of Life Sciences
South Kensington Campus

Postdoctoral Research Associate in ultrafast X-ray crystallography using X-ray Free Electron Lasers

Salary scale: £36,070 – £43,350 per annum
(Maximum starting salary £36,070 per annum)

Applications are invited for a Research Associate position available in the group of Dr Jasper van Thor at Imperial College London. The successful candidate will join a multidisciplinary research group working on femtosecond structural dynamics of proteins using XFEL crystallography as well as ultrafast spectroscopy using a state-of-the-art ultrafast spectroscopy laboratory at the South Kensington Campus.

The research involves executing femtosecond time resolved pump-probe X-ray protein crystallography studies at X-ray Free Electron Lasers (XFELs). The main duties include time resolved protein crystallography with an emphasis on data processing and analysis using the technique of Serial Femtosecond Crystallography (SFX). You will also supervise Research Technicians in their duties to create and prepare micro-crystals of light sensitive proteins suitable for Serial Femtosecond Crystallography. Advanced skills and experience with scientific computing, preferably python, matlab, labview, C++ are expected. Previous experience using X-ray Free Electron Lasers and associated data processing tools (Cheetah, CrystFEL) would be an advantage. The post holder will also be required to travel to USA, Germany, Switzerland, Korea and Japan for XFEL experiments
This is a full time position available for up to 48 months.

Our preferred method of application is online via our website www.imperial.ac.uk/employment (please select “Job Search” then enter the job title or vacancy reference NS 2017 023 LP number including spaces – into “Keywords”). Please complete and upload an application form as directed.

For informal enquiries please contact Dr Jasper van Thor j.vanthor@imperial.ac.uk. Should you have any queries about the application process please contact by email at dols.recruitment@imperial.ac.uk and refer the job reference number.

Closing Date: 1 May 2017 (Midnight GMT)

[Post Date: March 08, 2017]

Title: Part Time Research Technician

Imperial College London
Department of Life Sciences
South Kensington Campus

Part-time Research Technician Biochemistry/Crystallography

Salary scale: £30,160 – £34,270 p.a. (pro rata)
Maximum starting salary £30,160 p.a.) (pro rata)

A Research Technician position is available in the group of Dr Jasper van Thor at Imperial College London’s South Kensington Campus. Working as part of the group, you will provide support primarily in recombinant protein production and crystallization. As a Key member of the group you will work closely with laboratory members in the area of femtosecond laser spectroscopy and ultrafast time resolved protein X-ray crystallography.

The main duties of the post are to maintain and develop the biochemistry procedures needed for protein production and crystallization. The post holder will provide sample preparation support to members of the laboratory. You will also carry out recombinant protein production and purification, protein crystallisation, and molecular biology procedures including mutagenesis. The post holder will also be required to travel to USA, Germany, Switzerland, Korea and Japan to provide support during XFEL trips

You must have or a BSc (or equivalent) in Biochemistry, Biology, Chemistry plus work experience or HNC/HND level qualification plus substantial work experience in a relevant Technical or scientific role. Experience in laboratory-based and laboratory biochemical procedures are essential. Knowledge of molecular biology and recombinant protein purification techniques are essential.
The position is part time of 17.5 hours per week and it is available for up to 37 months, with a possibility of extension subject to funding.

For informal enquiries please contact Dr Jasper van Thor – j.vanthor@imperial.ac.uk

Our preferred method of application is online via our website www.imperial.ac.uk/job-applicants/ (please select “Job Search” then enter the job title or vacancy reference NS 2017 025 LP number including spaces – into “Keywords”). Please complete and upload an application form as directed.

Should you have any queries about the application process please contact by email at dols.recruitment@imperial.ac.uk and refer the job reference number.

Closing Date: 1 April 2017 (Midnight GMT)

[Post Date: March 08, 2017]

Title: Postdoc AstraZeneca
Website: https://tinyurl.com/hae2cxo

At AstraZeneca, we believe in the potential of people who share our passion for science. By thinking boldly and working collaboratively to pursue discoveries beyond imagination, you’ll develop further and faster than you thought possible. We’ll complement your drive and determination to meet unmet patient needs around the world with the inspiration and opportunities to enhance your niche expertise and build your skills. So if you’re curious about what science can do, come and make a difference.

Our Discovery Sciences team operates from truly state-of-the-art centres spanning the UK, US and Sweden. You’ll work with some of the most knowledgeable technology experts in the industry, all collaborating on high-profile drug discovery projects. With a wide range of responsibilities, from sample management and screening to bio-reagent supply, the opportunities to develop your expertise here are limitless.

Main duties and responsibilities

PostDoc long title: Functional, biophysical and structural characterisation of a multicomponent transcription factor complex.

Nuclear hormone receptors are ligand activated transcription factors that are critical for both development and a broad range of physiological processes. We’re looking for a talented postdoctoral scientist to join our Post Doc Programme to study the structure and function of a highly important full-length receptor in complex, state-of the art ligands and link this information to broader mode of action studies for active clinical projects. In addition, you’ll take part in a comprehensive training programme with a focus on drug discovery and development.

You’ll gain in-depth receptor experience from extensive discovery projects and technical expertise from both AstraZeneca and the academic collaboration laboratory at CBI.

Specifically, you’ll design, express and purify a broad range of receptor constructs across several expression systems, as well as characterising ligands with different pharmacological profiles using biophysical techniques and functional assays. You’ll also determine complex structures with either X-ray crystallography or other complementary techniques such as SAXS and high-resolution cryo-EM, and explore the allosteric pathways in between the ligand binding function and different DNA response elements and co-regulator proteins. Presenting your results at scientific conferences and writing/publishing scientific papers in high-quality, peer-reviewed journals is expected.

Essential requirements

PhD and/or MD in biochemistry, biophysics or structural biology
Significant experience of protein expression methods using mammalian and insect cells
Strong background in construct design, molecular biology and protein purification
Familiarity with biophysical and structural techniques
Genuine understanding and experience of different assay technologies
Strong organisational and interpersonal skills
A proven record of work published in reputable scientific journals.

Desirable requirements

Experience of working with the following technologies: Protein Crystallization, X-ray crystallography, Small Angle X-ray Scattering, Electron Microscopy, Isothermal Titration Calorimetry and Surface Plasmon Resonance
Experience of expressing and purifying challenging protein complexes
Experience of working with DNA binding proteins.

To apply for this position, please click the apply link below

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

This is a 2-year, fixed-term contract based in Gothenburg, Sweden with a competitive salary on offer.

Closing date: 18th April 2017


[Post Date: March 07, 2017]

Title: Postdoc

A fully funded postdoctoral position (up to 5 years) is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between the accelerated discovery and functional description of the noncoding transcriptome, and a paucity of 3D structures and mechanistic understanding of complex noncoding RNAs. We seek a new member to join our diverse group to deepen current work on gene-regulatory riboswitches, highly structured viral RNAs, circular and other structured long noncoding RNAs. https://www-mslmb.niddk.nih.gov/zhang/zhanglab.html

Current manuscripts and recent publications:
1. Li et al., & Zhang (2017) Structural basis of amino acid sensing on the tRNA by a T-box riboswitch. In preparation.

2. Bahmanjah et al., & Zhang (2017) Structural basis of functional repurposing of an aminoacyl-tRNA synthetase in stress response. In preparation.

3. Hood et al., & Zhang (2017) Structural mimicry of codon-anticodon interactions by a viral noncoding RNA. In preparation.

4. Zhang & Ferré-D'Amaré (2014) Dramatic improvement of crystals of large RNA by cation replacement and dehydration. Structure 22, 1363-1371.

5. Zhang & Ferré-D'Amaré (2014) Direct evaluation of tRNA aminoacylation status by the T-box riboswitch using tRNA-mRNA stacking and steric readout. Molecular Cell 55, 148-155.

6. Zhang & Ferré-D'Amaré (2013) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA. Nature 500, 363-7.

The lab is part of the Earl Stadtman Investigator program for high-risk, high-impact research at the NIH intramural program consisting of 1100 labs. The well-supported lab has dedicated access to state-of-the-art equipment in structural biology (Mosquito, Dragonfly, Rock Imager, Akta Pures, FSEC, for X-ray crystallography; new Titan Krios for single-particle Cryo-EM; SAXS, AFM, etc), efficient biochemistry, biophysics (ITC, DSC, SPR, BLI, AUC, DLS, SEC-MALS, CD, fluorescence, thermophoresis, etc), fermentation, genomics, and proteomics core facilities with hands-on training or service by PhD-level staff scientists. The NIH, NIDDK, and LMB are committed to the continued education and career development of trainees through numerous courses and workshops offered by NIH OITE and FAES.

Requirements: Interested candidates must have received (or be expecting) a Ph.D. or M.D. within the past five years in molecular or structural biology, biochemistry, or biophysics, and be strongly self-motivated to lead innovative and rigorous research projects. Strong background in protein expression and purification, enzyme kinetics, and structural biology is desirable.

To apply: Please email a preferred start date, CV, a brief summary of research interests, accomplishments, and career goals, and names and contact information for at least three references to: Dr. Jinwei Zhang, Email: jinwei.zhang@nih.gov. The NIH is dedicated to building a diverse community and DHHS/NIH is an Equal Opportunity Employer.

[Post Date: March 07, 2017]

Title: Research Scientist Crystallographer

The Structural Research Group at our Oncology Site Vienna is seeking an experienced Protein Crystallographer in the field of pharmaceutical research and drug design. We are looking for a candidate with outstanding professional and personal competencies, highly motivated and with the ability to act agile, as an individual contributor as well as a team player.

Duties & Responsibilities

• Determine the atomic structures of new proteins of interest and of protein-ligand complexes using protein crystallographic methods in high throughput modes
• Expert analysis of relevant data and related literature to extract important structural insights and drive drug discovery efforts with timely communication to project teams
• Utilize fragment-based screening methods to guide successful hit finding activities
• Provide guidance to crystallization and protein construct design efforts
• Analyze literature for novel drug targets and prepare new project proposals in close collaboration with biologists and medicinal chemists
• Maintain accurate and timely records of experimental results
• Possibility to publish in peer-reviewed journals and present at external scientific meetings


• Doctoral degree or equivalent in Biochemistry, Biophysics, Chemistry or related field
• Postdoctoral training in protein crystallography with ca. 2-5 years of industrial or related academic experience in modern Crystallography techniques
•Passionate about using structural data to influence key scientific decisions
• Strong hands on skills in molecular biology and protein biochemistry
• Proven ability to write own scripts in Linux environment and to utilize cheminformatics tools
• Broad knowledge in protein characterization, biophysics, computational chemistry and medicinal chemistry will be helpful to drive projects forward
• Experiences in CryoEM preferred but not mandatory

Please only apply via BI web interface!



[Post Date: March 04, 2017]

Title: Research Fellow
Website: http://jobs.leeds.ac.uk/FBSAS1006

Research Fellow in Structural Molecular Biology

Are you looking to apply your skills in Structural Biology to the development of new approaches for discovery of protein-protein interaction inhibitors?

Protein-protein interactions (PPIs) control all cellular processes relevant to health and disease. Selective inhibition of individual PPIs would thus facilitate both a greater understanding of biological mechanisms and provide new opportunities for therapeutic intervention. Presently, PPI inhibitors represent a minute fraction of current small molecule drugs, this is largely because of specific challenges associated with development of inhibitors for these targets.

The Perturbation of Protein-Protein Interactions (PoPPI) project is a major £3.4 million five-year collaborative research programme led by Professor Andy Wilson, funded by the Engineering and Physical Sciences Research Council (EPSRC), and bringing together the University of Leeds, the University of Bristol, the Northern Institute of Cancer Research (Newcastle University) and drug discovery organisations, AstraZeneca and Domainex. This large and diverse programme focuses on developing, validating and exploiting new tools to discover inhibitors of PPI’s. This position will use structural biology and biophysics to assess the application of our methods for preparing inhibitors of multiple PPIs. The position will provide multiple opportunities for personal development, as well as the possibility of research secondments at Bristol and our drug discovery partners.

You should have, or be about to obtain, a PhD in Biochemistry or related biological science with expertise in Structural Chemistry. You will work closely, interactively and collaboratively with project team in an interdisciplinary setting, so you will need excellent communication skills, the ability to work under pressure and to meet deadlines.

To view the advert with details of how to apply use the link below:


Closing Date: Thursday 30 March 2017

[Post Date: March 03, 2017]

Title: Postdoc Shanghai Tech University

Several postdoc positions are immediately available in Prof. Ian A. Wilson’s Lab of Antibody Structure at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University (http://siais.shanghaitech.edu.cn/eng/research7.asp), China. SIAIS is an innovative research institute dedicated to the fundamental problems in life science, particularly in the field of immunology.

The Lab of Antibody Structure utilize a multidisciplinary approach to study the structures and functional mechanisms of key molecules/complexes in innate and adaptive immunity, with a long-term goal of understanding and modulating the functions of important immune receptors and effectors for the prevention and treatment of various immune disorders, microbial infections or cancers.

We are now seeking self-motivated talents to join us. Candidates for postdoctoral positions should:
--- hold or will have a Ph.D. degree in biophysics, bioinformatics, biochemistry or cell biology
--- have a strong academic research background
--- have a publication record commensurate with experience
--- manifest good problem solving, interpersonal and communication skills
— Outstanding candidates with different skill sets will be taken into consideration, spanning from structural biologists with experience in crystallography and cryo-EM, to cell biologists with experience in cellular trafficking, to bioinformatics with experience in homology modeling and simulation.

If interested, please send a cover letter, a curriculum vitae with publication list and three references to siais@shanghaitech.edu.cn (cc: yangbei@shanghaitech.edu.cn). Salary will be commensurate with experience. The positions remain open until filled.

[Post Date: March 02, 2017]

Title: Postdoc & Research Tech

Postdoc – http://www.fredhutch.org/job/9073

Research Tech – http://www.fredhutch.org/job/9072

The Stamatatos lab, within the Vaccine and Infectious Disease Division, works towards the development of a safe and effective vaccine against HIV-1. Our major emphasis is the design of protein immunogens and understanding the immune response following vaccination or natural infection. The subgroup led by Dr. Pancera focuses on structural characterization of these immunogens and their immune responses. The laboratory utilizes a wide range of in vitro and in vivo systems and cutting-edge technologies and techniques. Experimental approaches include high-throughput crystallography, specialized immunological methodologies and assays, molecular and cellular biology techniques, bioinformatics, and computational approaches.

Our lab is seeking an outstanding Postdoctoral Fellow to work on a project involving the characterization of the humoral immune response to HIV-1 infection and HIV-1 vaccines using X-ray crystallography.

1. Responsible for crystallization of the proteins/antibodies complexes and for solving and refining their structures
2. Conduct protein expression and purification experiments, including affinity purification, Ion exchange and FPLC, related to the production of antibodies against viral glycoproteins for structural biology
3. May involve use of Electron Microscopy, molecular modelling or structure-based mutagenesis and design
4. May involve use of Bio Layer interferometry, SPR and ELISA
5. Initiate and carry out scientific projects, under the supervision of Dr. Pancera
6. Develop and demonstrate a thorough understanding of the scientific literature relating to the research topics.
7. Conduct and publish research in HIV structural biology.

PhD in Structural Biology, Protein Chemistry, Biochemistry or a related field is required with significant expertise in X-ray protein crystallography. Candidates with backgrounds in areas such as virology, protein biochemistry, and vaccine development are strongly encouraged to apply. On-hands experience with diverse aspects of Molecular Biology is required. Experience in X-ray crystallography including up-to-date knowledge of relevant programs including CCP4, and Phenix packages, protein purification, protein characterization, and a strong publication history are strongly desired. Knowledge of Cryo-EM is not required but desirable. Additional expertise with tissue culture and immunological assays is a plus.

[Post Date: March 01, 2017]
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