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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Professor in Molecular Biology

Description:
Professor in Molecular Biochemistry

Field and Location: The Faculty of Biochemistry and Molecular Medicine of the University of Oulu (http://www.oulu.fi/fbmm/) announces opening of a Professorship in Molecular Biochemistry. The position is located at the Faculty of Biochemistry and Molecular Medicine, whose mission is to perform internationally significant research and to deliver high-level undergraduate and post-graduate education in the fields of biochemistry and molecular medicine. The research carried out at the Faculty focuses currently on cell-extracellular matrix, protein science and cellular regulatory and metabolic networks and related diseases. The research is carried out in 14 research groups. The Faculty has about 200 employees and about half of them are from abroad. It is considered as an advantage if the applicant’s research is related to the above focus areas the Faculty.

Together with Biocenter Oulu (http://www.oulu.fi/biocenter/), the Faculty has put a great effort towards building a cutting-edge research infrastructure that includes state-of-the-art instrumentation for imaging, gene modified mice, X-ray crystallography and quantitative biochemistry. The Faculty has extensive collaborative national and international networks including Biocenter Finland and the ESFRI projects Instruct, EuroBioimaging and Infrafrontier. We also partner in EU-Biostruct-X, Marie Curie Renaltract ITN and organize EMBO workshops and other international symposia. The Faculty has a joint PhD degree program and a double MSc degree program with University of Ulm.

Required qualifications: A person appointed to the position of a professor must have a doctoral degree, high level scientific competence, and experience in leading scientific research ability to provide high-level research-based teaching and theses supervision. It is also expected that the person to be recruited has a good record in obtaining external funding and is able to participate in international co-operation projects in his/her field of expertise.

When evaluating the competency of an applicant the tenure track guidelines according to the University of Oulu are followed. The qualifications to considered are scientific publications and other research results with scientific value, patents, teaching experience and pedagogic training, ability to produce teaching material, other merits as a teacher, teaching demonstrations and supervised doctoral theses. Other factors to be taken into consideration are the activeness of the applicant in the international scientific community, academic work abroad and other international positions. The teaching languages at the Faculty are Finnish and English.

Salary: The basic salary is based on the demand level chart 8-10 (4656.16-5934.94 €/month) for the teaching and research staff of Finnish Universities. In addition to the basic salary, supplementary salary will be given for personal achievement and performance, the sum rising to a maximum of 46.3 % of the basic salary level for the post (total maximum 8682.82 €/month).

Applications: Applications, together with all relevant enclosures, should be submitted electronically by 4.3.2017.

The application should be written in English and the following information needs to be included:

1) an application letter with contact information

2) a curriculum vitae following the guidelines of the Finnish Advisory Board on Research Integrity (tutkimuseettinen neuvottelukunta). The guidelines are available at http://www.tenk.fi/en/templateresearchers-curriculum-vitaeand a template at http://www.tenk.fi/sites/tenk.fi/files/CV_english_270613.pdf.

3) list of publications, ten most important ones marked

4) a brief account of research merits (max 1 page)

5) a brief account of teaching merits or a teaching portfolio and teaching plans (max 2 pages)

6) acquisition of research funds and international collaborator networks

7) a brief research and action plan (max 3 pages)

Evaluation: The selection procedure will be carried out by an Recruitment Committee according to the University of Oulu guidelines.

Contact details: In order to receive the information and announcements concerning the official selection procedures to be followed in order to fill this post, applicants must inform the Faculty of their contact details for the whole duration of the selection process: they must specifically provide both their home and work telephone numbers, e-mail addresses, fax numbers and postal addresses.

For further information and enquiries about this post, and about the application and selection procedures, please contact:

Prof. Thomas Kietzmann, Head of Recruitment Committee
Faculty of Biochemistry and Molecular Medicine,
University of Oulu,
P.O. Box 5400, FI-90014 University of Oulu, Finland,

Prof. Peppi Karppinen, the Dean of the Faculty
Faculty of Biochemistry and Molecular Medicine, University of Oulu
P.O. Box 5400, FI-90014 University of Oulu, Finland,

Tiina Hurskainen, Chief Administrator
Faculty of Biochemistry and Molecular Medicine,
University of Oulu,
P.O. Box 5400, FI-90014 University of Oulu, Finland

email: firstname.lastname(at)oulu.fi

web: http://www.oulu.fi/fbmm/


[Post Date: January 20, 2017]

Title: Postdoc

Description:
The Grishin (http://prodata.swmed.edu/) and Chook (http://www4.utsouthwestern.edu/chooklab/) Labs at UT Southwestern seek a recent PhD graduate for a postdoctoral fellow position to study structural determinants of nuclear export signals and predict them in protein sequences. The project will involve both experimental and computational approaches. The experimental aspect requires experience in protein crystallography, biochemical and biophysical techniques. The computational aspect will involve sequence bioinformatics and structure modeling techniques. Synergy between computation and experiment is key to this project.

Applicants should hold a recent PhD degree and have strong laboratory skills in all aspects of protein crystallography. Computational biology experience is helpful. Good communication and organizational skills are critical.

Please email application to YuhMin.Chook@utsouthwestern.edu

Application should include curriculum vitae, a summary of current and future research interests, a description of past research experience and accomplishments, expected availability date and three references.


[Post Date: January 19, 2017]

Title: Postdoc
Website: https://euraxess.ec.europa.eu/jobs/163137

Description:
Postdoctoral fellowship opportunity in structural chemistry at the UiT The Arctic University of Norway in Tromsø. The project area is "Crystallography, biophysical and cheminformatics studies for next-generation kinase inhibitor design".

The program is described in more detail here:

https://euraxess.ec.europa.eu/jobs/163137

The deadline for a preliminary application (2 pages and a CV) is soon, February 3.

Promising candidates will then be invited to prepare a more detailed application for submission in autumn. If the application is successful, the position will be funded starting in 2018.

Besides hosting the Norwegian Center for Structural Biology, Tromsø is a fascinating location, with its 2-month long "Polar Night", illuminated by some midday twilight and Northern Lights, and its compensating 2-month long Midnight Sun period. (We don't lack total sunshine hours, but have only about 245 sunrises and sunsets per year, depending on the view of the horizon from where you live.) As the link above describes it, Tromsø is "uniquely located at the top of the world surrounded by some of Europe’s last pristine wild nature."


[Post Date: January 19, 2017]

Title: Positions Available Institute of Cancer Research

Description:
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment. Under the leadership of our Chief Executive, Professor Paul Workman FMedSci, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The Cancer Research UK Cancer Therapeutics Unit, within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The Cancer Therapeutics Unit’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the scientific disciplines are in place to make this possible, including medicinal chemistry, biology, drug metabolism and clinical specialists who focus on new molecular targets emerging from human genome and ground breaking cell biology research.

In addition to the recently advertised postdoctoral protein crystallography position available in Dr Rob van Montfort’s Hit Discovery and Structural Design Team within the CTU (Ref. 1624336, closing date January 27th 2017) a second postdoctoral protein crystallography position is now available in Dr van Montfort’s team (Ref. 1627317). The successful candidate will establish the successful expression, purification and characterisation of one of our early stage targets, using contemporary expression systems and purification methods available within the Team. The Post-doc will establish the in-house crystallisation and structure determination for this exciting early stage target in CTU’s drug discovery portfolio and subsequently carry out the structural determination of protein-ligand complexes. In addition, the post-holder is expected to initiate the development of biochemical and biophysical assays development to monitor protein function. The successful candidate will be an integral member of a multidisciplinary project team and will interact closely with the biologists, computational chemists, medicinal chemists and structural biologists and will therefore be expected to work across the two sites in Chelsea, London and Sutton, Surrey. Applicants must have a PhD in a biological or physical science, and experience in macromolecular crystallography (to include protein biochemistry, protein crystallisation, & protein crystallography). Expertise in assay development and biophysical techniques would be advantageous. The starting salary for this position will be up to £35,538p.a. inclusive (based on previous experience). Appointment will be on a fixed-term contract for 1 year and benefits from a contributory defined benefit pension scheme and generous leave entitlement.

We are also seeking two highly motivated Higher Scientific Officers with experience in protein expression and purification to join Dr van Montfort’s team (Ref. 1627310). The postholders will be involved in establishing and carrying out the protein expression, purification, and characterisation of cancer targets to enable biochemical screening, high-throughput protein crystallography and Structure-Based Drug Design projects at the Unit. Applicants must be educated to degree level in a biological science and will ideally have an MSc or PhD in a relevant subject. Experience and demonstrable skills in molecular biology, protein expression in E.coli and protein purification are essential. Experience in protein expression in insect and/or mammalian cells and or biophysical techniques such as SPR, DSF and ITC is highly desirable.The starting salary for the two positions will be in the range Point 1 £32,145 - Point 4 £36,080 p.a. according to experience and the posts are offered initially on a fixed term contract 2 year contract.

Closing date for the three positions (Ref. 1627317 and Ref. 1627310) is February 17th 2017. Informal enquiries to rob.vanmontfort@icr.ac.uk - but applications must be submitted on-line (www.icr.ac.uk).


[Post Date: January 18, 2017]

Title: Postdoc

Description:
Two postdoctoral research associate positions are immediately available for highly motivated, well-organized scientists in Prof. Limei Zhang’s group at the Dept. of Biochemistry and the Redox Biology Center, University of Nebraska-Lincoln, USA (http://biochem.unl.edu). The research in the Zhang Laboratory focuses on the structure-mechanism relationships of metalloproteins in the stress response and pathogenesis of Mycobacteria using non-pathogenic bacteria as models. Multi-disciplinary approaches are used in the studies, including synchrotron radiation-based X-ray diffraction and spectroscopy, molecular biology and computational modeling. Applicants must have a recent PhD degree (or expected soon) and proven skills and experience in either molecular biology or protein crystallography. Candidates with excellent communication and collaborative skills are desirable. The position offers competitive salary and benefits package.

The University of Nebraska-Lincoln is located in a vibrant and safe city offering outstanding and affordable quality of life, and numerous multi-cultural and entertainment benefits. The Redox Biology Center is organized as a broad-based interdisciplinary and multi-institutional entity involving researchers from the University of Nebraska-Lincoln and the University of Nebraska Medical Center in Omaha, and offers supportive and collaborative international environment as well as access to cutting edge proteomics, metabolomics, crystallography, and NMR facilities.

To apply for the position, please submit your curriculum vitae, the names and contacts of three references to limei.zhang@unl.edu.


[Post Date: January 15, 2017]

Title: Postdoc

Description:
Two Postdoctoral Positions are available in the Genome Stability Unit @ St Vincent’s Institute in Melbourne, Australia.

The Genome Stability Unit studies familial cancer syndromes that cause predisposition to breast/ovarian cancer, leukaemias and other solid tumours. These families inherit a defect in the ability to maintain genome stability and accumulate mutations at a faster rate, thus cancer occurs earlier in life with a higher probability. This mechanism of genome stability is intricate and involves a number of signalling and DNA repair pathways. We reconstitute these pathways biochemically using recombinant proteins and synthetic DNA molecules. Together with local and international partners, we aim to understand DNA repair function and suitability for drug targeting. We are looking for full-time postdoctoral leaders of two fully-funded projects:

Project 1: Functional analysis of new breast cancer predisposition genes.

Offers the challenge of developing a new biochemical functional test for several breast cancer predisposition genes linked to defects in DNA repair. This project is funded by the National Breast Cancer Foundation, and the postdoc would participate in a large Australia-wide consortium into familial breast cancer predisposition. Experimental approaches include working with patient samples, producing recombinant proteins, assaying DNA repair activity in vivo and in vitro, and integrating findings with data collected from over 11,000 individuals from predisposed families. Structural biology components to the project are available to those with experience/interest, and the Institute is close to the Australian Synchrotron beam line.

Project 2: Development of new chemotherapy sensitisers.

Offers the challenge of identifying new drugs for the treatment of cancer, and cancer predisposition disorders. In this project the postdoc would undertake preclinical analysis of drug hits identified as inhibitors or activators of DNA repair signalling. There would be a particular focus on the Fanconi Anaemia DNA repair pathway, for which the lab has international expertise. Elements of the project include biochemical reconstitution of DNA repair processes, and assaying and improvement of drugs identified in lab-based screens.

Coming from a strong scientific background, you will be expected to have:

creativity and scientific curiosity

independence and ability to collaborate

a PhD in biology, medicine or chemistry discipline (or completing in early 2017)

a track record of producing quality results in a laboratory setting

at least one first author paper in a strong, peer-reviewed publication

Nice-to-have (but we can teach you if you don’t):

knowledge of DNA repair pathways and processes

expertise in protein chemistry, cell biology, genetics or oncology (project 1)

expertise in protein chemistry, drug screening, preclinical development (project 2)

Australian postdoc salaries are considerably higher than in the US or Europe $74,689-$93,888 (dependent upon experience).
+9.5% superannuation
+generous $15,900 tax-exempt salary packaging
Melbourne is considered one of the world’s most liveable cities, and is one of the top six biotech hubs:
Research themes and publications http://genomestability.weebly.com
Applications (or enquiries) should be addressed to Dr Andrew Deans adeans@svi.edu.au (for project 1) or Dr Wayne Crismani wcrismani@svi.edu.au (for project 2). Applications should include a cover letter addressing suitability and ambition for the position, 2-3 page CV and academic referee contact information. Please apply by January 31, 2017.



[Post Date: January 11, 2017]

Title: Postdoc

Description:
Post-doctoral position in cryo-EM/structural biology of multiprotein kinase signalling complexes

Project: Structural and functional analysis of a multiprotein kinase signalling complex involved in mediating immune responses in eukaryotes.

Methods: Hybrid approaches in structural biology: cryo-EM, X-ray crystallography, SAXS, NMR, computational methods, bioinformatics, biophysics and biochemistry. Functional characterization on a cellular and organismal level is carried out in close collaboration with the group of Dr. Heribert Hirt (KAUST).

Required skills: Experience in protein expression, purification and characterization; Expertise in structural methods, in particular cryo-EM and X-ray crystallography. A high level of motivation and the ability to work as part of a team are essential.

Location: Group of Stefan Arold at the King Abdullah University of Science and Technology (KAUST). KAUST, founded in 2009, is located at the shores of the Red Sea in Saudi Arabia. KAUST currently ranks nr. 1 worldwide in citations per faculty (QS World University Rankings 2015/2016) and provides outstanding research facilities (incl. a Titan KRIOS with direct detector, NMR spectrometers up to 950 MHz & in-house X-ray source). KAUST has a community with more than 100 nationalities, pristine coral reefs and about two hours of rain per year.

Remuneration: highly competitive salary, commensurate with experience, and various benefits.

Starting Date: available from April 2017, but later starting dates can be accomodated

Contact: Please send a CV, a statement of research experience and contact information for at least two referees to stefan.arold@kaust.edu.sa.


[Post Date: January 10, 2017]

Title: Scientist
Website: http://abbvie.taleo.net/careersection/jobdetail.ftl?job=1608252&lang=en

Description:
Senior Scientist II, Structural Biology-1608252

AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. AbbVie employs approximately 28,000 people worldwide and markets medicines in more than 170 countries.

Description
The Protein Crystallography Group at AbbVie Headquarters in Lake County, Illinois is seeking a highly motivated scientist to join our Structure-Based Drug Discovery team. The ideal candidate should have extensive hands-on experience in modern X-ray Crystallography techniques and computational methods of molecular structure analysis. As part of multidisciplinary teams, the Senior Scientist will utilize fragment-based strategies to identify ligands and provide insight to advance drug discovery targets through structure-based design. The successful candidate will contribute to drug discovery projects across the portfolio of AbbVie interests that also include therapeutic antibodies and novel biologics.


[Post Date: January 09, 2017]

Title: Postdoc Molecular Therapeutics Program

Description:
Postdoctoral positions are available immediately in the Molecular Therapeutic Program at Fox Chase Cancer Center (Philadelphia, PA) for highly motivated individuals in the field of structural biology of cell signaling.

The main focus of the lab is to understand the molecular basis for the cell signaling events that contribute to tumor metastasis by affecting cell adhesion. More details can be found at https://www.foxchase.org/people/jinhua-wu.

Candidates with experiences in protein crystallography, molecular biology, mammalian cell culture, and protein biochemistry are preferred. Prior experiences in flow cytometry, receptor biochemistry, cancer biology, and electron microscopy are desired but not required. The candidate should hold a Ph.D degree in a related field with 5-8 years of work experience. Fox Chase Cancer Center is a long-standing NCI-designated Comprehensive Cancer Center with multidisciplinary research interests from basic biological sciences to drug development and clinical studies. The institute is one of the top-ranked work places for postdoctoral researchers. It offers an outstanding research environment and strong support for postdoctoral career development.

Please send a cover letter describing previous research experiences, an updated CV, and a list of three references to: Jinhua.wu(a)(a)fccc.edu.


[Post Date: January 06, 2017]

Title: Research Fellow

Description:
Job description
Dr. Julien’s laboratory at The Hospital for Sick Children Research Institute is looking for a Research/Post-Doctoral Fellow to join our Structural Biology team. The successful candidate will participate in the characterization of a malaria antigen and antibodies against it by using a combination of biochemical, biophysical, immunological and structural techniques. We are looking for a driven and enthusiastic scientist who demonstrates passion and creativity towards the structure/function study of important pathogenic targets and who can thrive in a highly-collaborative setting.

Roles & Responsibilities
• Design and optimize constructs for expression in E.coli, insect cells (Sf9) and mammalian cells (HEK 293F);
• Biophysically characterize purified antigens for their Tm, Tagg and polydipersity with the objective to improve crystallizability;
• Perform ITC and BLI binding assays between antigens and purified antibodies to determine binding thermodynamics and kinetics;
• Determine X-ray crystal structures of antigens and antigen-antibody complexes at atomic resolution;
• Use Electron Microscopy to screen constructs and to determine the molecular structure of antigen-antibody complexes at nanometer resolution.

Desired Skills and Experience
• Structural Biologist with a PhD in Biochemistry, Immunology, Molecular Biology, or related field;
• Experience in molecular biology, protein expression in various systems, purification and biophysical characterization (Octet, Optim, ITC, SEC-MALS);
• Strong knowledge in using structural biology to study malaria antigens, especially in a context of structure-based vaccine design is a plus;
• Practical experience in using in silico approaches to improve antibody-antigen binding interfaces is a plus;
• Demonstrated ability to participate in collaborative scientific projects;
• Organization skills, efficiency and meticulous record keeping.

About Us
Dr. Julien's laboratory is interested in the structure/function study of B cell receptors and their interactions with antigens. A better understanding of the structures of B cell surface molecules will serve towards the rational design of improved vaccine immunogens against a variety of pathogens, including malaria and HIV-1. Dr. Julien’s laboratory is located in The Peter Gilgan Centre for Research and Learning, a new 21-story, 750,000 square-foot facility that incorporates an open-concept design, state-of-the-art research facilities, and collaborative work spaces.

As a member of the SickKids community, you will become part of a world-renowned organization dedicated to fulfilling a vision of Healthier Children, A Better World. For over 135 years, SickKids has worked hard to make the world a better place for children and their families. SickKids researchers have developed Pablum, discovered the gene for cystic fibrosis and are on the leading edge of research in a wide range of disciplines. Each day, people around the organization are doing meaningful work that directly, and often indirectly, benefits children in Canada and around the world.

Please apply with CV and cover letter at: https://career.sickkids.ca/psc/CRPRD/CAREER/HRMS/c/HRS_HRAM.HRS_APP_SCHJOB.GBL?Page=HRS_APP_SCHJOB&Action=U&FOCUS=Applicant&SiteId=1


[Post Date: January 05, 2017]

Title: Postdoc University of Iowa

Description:
Postdoctoral Position in Mechanistic and Structural Enzymology at the University of Iowa

The Dey lab in the Department of Chemistry at the University of Iowa seeks to recruit an outstanding postdoctoral scientist with experience and interest in mechanistic enzymology, structural biology, and biophysical methods. The successful candidate will be responsible for the characterization of enzymes involved in methanogenesis. The lab uses a combination of biochemical, structural, and spectroscopic techniques to investigate enzyme structure-function. Previous experience in structural biochemistry, enzymology, and anaerobic manipulations would be valuable. This position provides the opportunity for broad training in protein expression, crystallization, kinetics, spectroscopy, and molecular biology.

Candidates must have their Ph.D. by the beginning date of the appointment in Biological Chemistry or a related discipline (Biochemistry, Chemistry, Molecular Biology and Biophysics, Microbiology, Pharmaceutical Sciences, Biochemical, and Biomedical engineering). The successful candidate will have strong experience in molecular biology, protein expression, purification, crystallization, and functional analysis. A significant publication record is an advantage. The candidate must have the ability to work independently and in a team.

The position is available immediately with funding for three years.

Interested applicants should send a cover letter, a curriculum vitae, and contact information of 2 individuals as references via e-mail to: mishtu-dey@uiowa.edu.

The University of Iowa is an equal opportunity affirmative action employer. Women and minorities are encouraged to apply.


[Post Date: January 05, 2017]

Title: Assistant/Associate Professor

Description:
The Department of Biochemistry in the Emory University School of Medicine is seeking to hire an Assistant/Associate Professor (tenure track) with expertise in structural biology and complementary biochemical/ biophysical approaches. The Department of Biochemistry is a leading research division within the School of Medicine with particular strengths in the application of structural biology, biochemistry and cell biology to understanding diverse fundamental biological processes that underpin human health and disease. These include but are not limited to the study of gene expression and control of protein synthesis, cell signaling, DNA repair and genome stability, and protein/ nucleic acid modification (for further details see: http://www.biochem.emory.edu/). Current Department faculty also bridge the School of Medicine’s basic research mission with other broader initiatives such as the Winship Cancer Institute, Emory Antibiotic Resistance Center (Emory ARC), Alzheimer’s Disease Research Center (ADRC), and Emory Vaccine and Treatment Evaluation Unit (VTEU) Systems Biology Center.

The successful candidate will have a Ph.D. (or equivalent) and postdoctoral experience in biochemistry and structural biology, or closely related disciplines(s). The selected candidate will be expected to build a dynamic, independent research program in the broadly defined area of structural biology, preferably using high-resolution single particle cryo-EM, x-ray crystallography, and/or single molecule optical microscopy studies, to build on Emory’s existing strengths in these areas. Selection criteria for this position will include a track record of scientific productivity, as evidenced by primary research publications and extramural funding, as well as the candidate’s future research vision and potential to contribute the Department’s graduate and medical student teaching.

Applicants should compile a single PDF file containing the following information:
1. Cover letter highlighting key qualifications.
2. Current curriculum vitae with complete bibliography.
3. Names and contact information of three references.
4. A research statement comprising descriptions of past accomplishments, including three publications that best epitomize the relevant skills of the applicant, and future research goals (3 pages total).

Application materials should be uploaded here:
https://sjobs.brassring.com/1033/ASP/TG/cim_jobdetail.asp?partnerid=25066&siteid=5449&areq=67992br

Initial review of applications will begin on February 15, 2017. Applications received after this date will be considered on a rolling basis until the position is filled.

Emory University is an Equal Opportunity/Affirmative Action/Disability/Veteran Employer. Applications from women and underrepresented minority candidates are strongly encouraged.

The Department maintains an in-house automated X-ray diffraction system (Rigaku MicroMax-007) along with robots for making and setting screens. We are members of the South East Regional Collaborative Access Team at Argonne National Labs providing for regular synchrotron access. To support Single Particle CryoEM, Emory recently purchased a 120 KV Talos L120C with Ceta 16M Camera and a 200 kV Talos Arctica with BioQuantum and K2/K3 Upgrade dedicated to single particle studies.


[Post Date: January 04, 2017]

Title: Postdoc HJF, MHRP, WRAIR
Website: http://www.hjf.org/careers/open-jobs.

Description:
A postdoc position is available in a newly formed Structural Biology Section, part of the US Military HIV Research Program, WRAIR in Silver Spring, Maryland, USA.

The position involves the application of structural biology to understanding viral glycoproteins and the immune response following vaccination or natural infection.

HJF is seeking a Postdoctoral Fellow to support the Military HIV Research Program (MHRP) located at the Walter Reed Army Institute of Research (WRAIR) in Silver Spring, Maryland. The incumbent will be responsible for initiating and carrying out scientific projects, under the supervision of senior scientists and in collaboration with other research scientists. The position involves the characterization of the humoral immune response to HIV-1 infection and HIV-1 vaccines using X-ray crystallography. The incumbent will be responsible for conducting and publishing research in HIV structural biology. The incumbent will work within a multidisciplinary environment consisting of military, government, academic, and international collaborators.

Responsibilities:
1. Conducts independent research and learns techniques required to conduct the research.
2. Assists in designing, developing, executing, and implementing scientific research and/or products.
3. Develops a thorough understanding of the scientific literature relating to the research topics.
4. Collects and handles samples and keeps detailed inventory and records of experiments by maintaining up to date, clear, and accurate laboratory notebooks.
5. Executes projects related to biochemical and structural characterization of antibodies, vaccine candidates and their complexes.
6. Analyzes experimental data, applying relevant statistical and bioinformatic models.
7. Presents data at scientific meetings and publishes original research in peer-reviewed journals.
8. Assists with training laboratory staff and collaborates with labs within and outside of MHRP.
9. Follows all MHRP and WRAIR safety procedures and completes required training in a timely manner.
10. Performs other duties as assigned.

Required Knowledge, Skills, and Abilities: PhD in structural biology or related area with significant experience in X-ray protein crystallography. Knowledge of appropriate scientific area; ability to analyze and interpret data. Experience and proficiency in protein purification, protein characterization, X-ray crystallography including up-to-date knowledge of relevant programs including CCP4, and Phenix packages. Experience with project planning, implementation, and data analysis. Experience in presenting at scientific meetings and writing manuscripts for scientific journals. Practical knowledge of electron microscopy, molecular modelling or structure-based mutagenesis and design is an advantage.
Minimum Education/Training Requirements: Ph.D. in structural biology, molecular biology, immunology, microbiology, biochemistry or related discipline.

Minimum Experience: 0-2 years of postdoctoral experience
Physical Capabilities: Long periods of standing and sitting; intricate work with hands; carrying of light and moderately heavy laboratory equipment. Job performance requires movement around and between several laboratories, and long periods of sitting at laboratory bench. Fine motor coordination in manipulation of laboratory materials is essential.
Supervisory Responsibilities/Controls: May provide guidance to laboratory staff.

Work Environment: Laboratory environment; may require working evenings and weekends. The incumbent will be expected to practice safe handling of hazardous chemicals. This laboratory is densely populated and requires good interpersonal skills for effective job performance. This position requires working and occasional travel to US synchrotron facilities. This Postdoctoral Fellow will support the US Military HIV Research Program, located at The Walter Reed Army Institute of Research (WRAIR) in Silver Spring, MD.

HJF is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.

Any qualifications to be considered as equivalents, in lieu of stated minimums, require the prior approval of the Director of Human Resources.


Interested and qualified individuals can apply through the following official link at Job ID: 212324 at the Henry M Jackson Foundation careers website: http://www.hjf.org/careers/open-jobs.

Applicants must be US citizens or have lived in the US for at least 3 consecutive years.





[Post Date: January 03, 2017]

Title: Postbaccalaureate NIH

Description:
Postbaccalaureate position for a membrane protein structure-function
project in the Anirban Banerjee lab at the NIH. The NIH Postbac IRTA program provides recent college graduates who are planning to apply to graduate or professional (medical/dental/pharmacy) school an opportunity to spend one or two years performing full-time research at the NIH.

Experience with protein purification, has good organizational skills and work ethics, and the right mindset to pay attention to nitty-gritty details that are essential for working with membrane proteins. The candidate should apply to the NIH Postbac Program
(https://www.training.nih.gov/programs/postbac_irta).

Postbac candidates have to be US citizens or permanent residents.



[Post Date: January 03, 2017]

Title: Postdoc Fellow US MHRP, WRAIR
Contact: M. Gordon Joyce, Ph.D.

Description:
A postdoc position is available in a newly formed Structural Biology Section, part of the US Military HIV Research Program, WRAIR in Silver Spring, Maryland, USA.

The position involves the application of structural biology to understanding viral glycoproteins and the immune response following vaccination or natural infection.

Interested and qualified individuals can apply through the following official link at Job ID: 212324 at the Henry M Jackson Foundation careers website: http://www.hjf.org/careers/open-jobs.

Applicants must be US citizens or have lived in the US for at least 3 consecutive years.
Please feel free to contact me at gjoyce@hivresearch.org if you have any questions.

HJF is seeking a Postdoctoral Fellow to support the Military HIV Research Program (MHRP) located at the Walter Reed Army Institute of Research (WRAIR) in Silver Spring, Maryland. The incumbent will be responsible for initiating and carrying out scientific projects, under the supervision of senior scientists and in collaboration with other research scientists. The position involves the characterization of the humoral immune response to HIV-1 infection and HIV-1 vaccines using X-ray crystallography. The incumbent will be responsible for conducting and publishing research in HIV structural biology. The incumbent will work within a multidisciplinary environment consisting of military, government, academic, and international collaborators.

Responsibilities:
1. Conducts independent research and learns techniques required to conduct the research.
2. Assists in designing, developing, executing, and implementing scientific research and/or products.
3. Develops a thorough understanding of the scientific literature relating to the research topics.
4. Collects and handles samples and keeps detailed inventory and records of experiments by maintaining up to date, clear, and accurate laboratory notebooks.
5. Executes projects related to biochemical and structural characterization of antibodies, vaccine candidates and their complexes.
6. Analyzes experimental data, applying relevant statistical and bioinformatic models.
7. Presents data at scientific meetings and publishes original research in peer-reviewed journals.
8. Assists with training laboratory staff and collaborates with labs within and outside of MHRP.
9. Follows all MHRP and WRAIR safety procedures and completes required training in a timely manner.
10. Performs other duties as assigned.

Required Knowledge, Skills, and Abilities: PhD in structural biology or related area with significant experience in X-ray protein crystallography. Knowledge of appropriate scientific area; ability to analyze and interpret data. Experience and proficiency in protein purification, protein characterization, X-ray crystallography including up-to-date knowledge of relevant programs including CCP4, and Phenix packages. Experience with project planning, implementation, and data analysis. Experience in presenting at scientific meetings and writing manuscripts for scientific journals. Practical knowledge of electron microscopy, molecular modelling or structure-based mutagenesis and design is an advantage.

Minimum Education/Training Requirements: Ph.D. in structural biology, molecular biology, immunology, microbiology, biochemistry or related discipline.

Minimum Experience: 0-2 years of postdoctoral experience

Physical Capabilities: Long periods of standing and sitting; intricate work with hands; carrying of light and moderately heavy laboratory equipment. Job performance requires movement around and between several laboratories, and long periods of sitting at laboratory bench. Fine motor coordination in manipulation of laboratory materials is essential.

Supervisory Responsibilities/Controls: May provide guidance to laboratory staff.

Work Environment: Laboratory environment; may require working evenings and weekends. The incumbent will be expected to practice safe handling of hazardous chemicals. This laboratory is densely populated and requires good interpersonal skills for effective job performance. This position requires working and occasional travel to US synchrotron facilities. This Postdoctoral Fellow will support the US Military HIV Research Program, located at The Walter Reed Army Institute of Research (WRAIR) in Silver Spring, MD.

HJF is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.

Any qualifications to be considered as equivalents, in lieu of stated minimums, require the prior approval of the Director of Human Resources.



[Post Date: December 30, 2016]

Title: Scientist/Senior Scientist GSK Vaccines

Description:
The Structural Biology Lab at GSK Vaccines, Rockville, MD, USA, is seeking a candidate for a Scientist/Senior Scientist position (Job ID: 148543, hiring managers: Enrico Malito, Matthew Bottomley). We offer outstanding opportunities and compensation to outstanding candidates. Anyone interested to apply can do so by visiting this link: https://careers.peopleclick.com/careerscp/client_gsk/external1931/en-us/gateway.do?functionName=viewFromLink&jobPostId=323652&localeCode=en-us (Please note that this may wrap to another line of text; you may need to copy and paste the entire URL into your browser window).

Applications will be accepted only through the page at the link above.

Examples of relevant recent publications:

- Rappuoli et al 2016. Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design. http://dx.doi.org/10.1084/jem.20151960
- Chandramouli et al 2015. Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody http://dx.doi.org/10.1038/ncomms9176
- Ciferri et al 2015. Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies http://dx.doi.org/10.1371/journal.ppat.1005230
- Malito et al 2015. Protein Crystallography in Vaccine Research and Development. http://dx.doi.org/10.3390/ijms160613106


[Post Date: December 22, 2016]

Title: Postdoc The Institute of Cancer Research

Description:
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment. Under the leadership of our Chief Executive, Professor Paul Workman FMedSci, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The Cancer Research UK Cancer Therapeutics Unit, within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The Cancer Therapeutics Unit’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the scientific disciplines are in place to make this possible, including medicinal chemistry, biology, drug metabolism and clinical specialists who focus on new molecular targets emerging from human genome and ground breaking cell biology research.

A postdoctoral position is available in Dr Rob van Montfort’s Hit Discovery and Structural Design Team within the CTU (Ref. 1624336). The Post-doc will be involved in high-throughput X-ray crystallography, fragment-based screening and structure-based drug design and will be responsible for crystallisation, structure determination and structural analysis of protein-ligand complexes from one of the CTU’s drug discovery programmes. The successful candidate will also be part of the Division of Structural Biology, in which the crystallographers in Dr van Montfort’s team are embedded, and will have access to state of the art crystallisation facilities, in-house X-ray sources and excellent access to synchrotrons. The successful candidate will interact closely with the biology, computational chemistry and medicinal chemistry teams at the CTU, and will therefore be expected to work across the two sites in Chelsea, London and Sutton, Surrey. Applicants must have a PhD in a biological or physical science, and experience in macromolecular crystallography (to include protein biochemistry, protein crystallisation, & protein crystallography). Experience in molecular biology, structure-based drug design, and/or biophysics will be an advantage. Starting salary will be in the range £34,247 to £36,830 p.a. inclusive (based on previous experience). Appointment will be on a fixed-term contract for 1 year and benefits from a contributory defined benefit pension scheme and generous leave entitlement.

Further information about these positions can be found in the full job description at www.icr.ac.uk. Informal enquiries to rob.vanmontfort@icr.ac.uk - but applications must be submitted on-line (www.icr.ac.uk). Closing date is January 27th 2017.


[Post Date: December 20, 2016]
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