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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Postdoc Case Western Researve University

Description:
Post-doctoral Research fellowship position available for crystallographer/protein chemist with molecular biology experience at the CCMSB, Case Western Reserve University.

Requirements:
• PhD in Biochemistry, Biophysics, Chemistry, Molecular Biology or similar
• Significant experience in protein structure determination using X-ray crystallography
• The individual should have the ability to manage projects and deadlines
• Good technical and troubleshooting skills

The Center for membrane and structural biology is well-equipped with core facilities including: x-ray diffraction, NMR, EM, mass spec, crystallization robots, ITC and fluorescence spectroscopy. The salary will be determined based on the experience of the candidate. CWRU is an equal opportunity employer.

Send your resume to Chris Dealwis on cxd114@case.edu

For more information please visit:

http://pharmacology.case.edu/department/faculty/primary/Pages/dealwis.aspx

https://www.ncbi.nlm.nih.gov/pubmed/?term=Chris+Dealwis



[Post Date: May 25, 2017]

Title: Postdoc University of Toronto

Description:
Postdoctoral Positions are available in the Laboratory of Structural Virology @ University of Toronto.

The Laboratory of Structural Virology, directed by Prof. Jeffrey E. Lee, is interested in understanding the structural and molecular mechanisms of key viral and cellular processes. Specifically, the thrust of our research is focused on two areas:
(a) Virus-cell and cell-cell fusion, and
(b) Anti-viral immune restriction factors.

Our goal is to reveal new strategies that viruses use to control cellular processes and pathogenesis, and to transform how we think about host-virus interactions. We employ novel hybrid methods that integrate X-ray crystallography, cryo-electron microscopy, small angle X-ray scattering, deuterium exchange mass spectrometry, biochemistry, and virology.

The lab has made seminal contributions with a strong publications record in the past 5 years (Cook et al. PNAS 2017; Aydin et al. Nature 2016; Siu et al. Nature Communications 2013).

Overall, the lab is well-equipped with excellent structural biology and biochemistry facilities. We have a fully-equipped protein expression facility for insect, human, bacterial, and yeast systems. Moreover, a full suite of biophysical (nanoITC, BLI, CD, UV/Vis, fluorescence polarization, SEC-MALS, DLS) and structural (Art Robbins Scorpion, Douglas Instruments Oryx 8, Formulatrix UV Rock Imager 1000, FRAP/fluorescence microscope) infrastructure is available in-house. Regular synchrotron access is available to the lab at the Canadian Light Source, Brookhaven NSLS-II, Advanced Photon Source (Chicago), and Advanced Light Source (Berkeley).

The lab is located directly in downtown Toronto on the main St. George campus at the University of Toronto within the Medical Sciences Building. The laboratory is in the heart of the Toronto Discovery District and close proximity to the University of Toronto-affiliated research hospital institutes.

A full description of the research themes and publications in the lab can be found at: www.leelab-utoronto.com

We are looking for full-time postdoctoral leaders for our two fully-funded projects.

Candidates are expected to have:
- scientific curiosity and creativity
- independence and ability to collaborate
- self-motivation, strong work ethics and dedication
- experience in molecular biology (cloning)
- knowledge of bacterial, insect or mammalian protein expression (bonus if candidate knows all three)
- expertise in X-ray crystallography, protein biochemistry, biophysics, and/or virology
- structural studies of macromolecular complexes by crystallography or cryo-EM are considered assets
- a recent PhD in structural biology, biochemistry or related discipline (or completing in 2017)
- a strong peer-reviewed publication record

Toronto is considered one of the world’s most dynamic and multi-cultural cities. It is consistently ranked top 5 most liveable cities in the world.

The position is fully-funded and scheduled for an immediate start. Applications (or enquiries) should be addressed to Prof. Jeffrey Lee jeff.lee@utoronto.ca I will be happy to discuss details of the projects. Applications should include a cover letter addressing suitability and ambition for the position, CV with list of first-authored publications, and academic referee contact information. The position will remain open until filled.


[Post Date: May 24, 2017]

Title: Postdoc Collège de France

Description:
A postdoctoral position is available in Beatrice Golinelli-Pimpaneau’s group at the Collège de France, 75005 Paris, France. In Marc Fontecave’s lab (https://www.college-de-france.fr/site/chimie-processus-biologiques/index.htm), the « RNA enzymology » group aims at understanding the structural and mechanistic details of tRNA modification enzymes.

Applicants must have (or will shortly be awarded) a PhD with training in protein biochemistry and crystallography. Experience in RNA in vitro transcription and/or work under anaerobic conditions within a glove-box will be of advantage. The successful candidate will be a highly motivated and enthusiastic individual with an outstanding academic track record, good communication skills and the ability to work as a team.
The post is for 12 months in the first instance and is available from July 17th, 2017.

Applicants should send their CV summarizing qualifications and experience, including the names and addresses of two referees to: Béatrice Golinelli
beatrice.golinelli@college-de-france.fr.


[Post Date: May 24, 2017]

Title: Postdoc Washington University St. Louis, Missouri

Description:
The Philips Laboratory in the Division of Infectious Diseases at Washington University in St. Louis, MO is recruiting a postdoctoral research associate to participate in NIH-funded projects. We are looking for a highly motivated postdoctoral associate to study host-pathogen interactions governing immune control of Mycobacterium tuberculosis (http://www.jenphilipslab.com/).

In particular, we are looking for candidates with prior training in protein biochemistry or structural biology to apply their training to study bacterial effectors. In collaboration with Dr. Thomas Brett’s laboratory, the candidate will crystalize an M. tuberculosis effector that is essential for innate immune evasion. The project will involve establishing assays to demonstrate the biochemical activity of the effector and screening for small molecule inhibitors.

Applicants should have a strong interest in tuberculosis, microbial pathogenesis, and innate immunity, but need not have worked in these areas previously. A CV and research statement should be sent to Jennifer A. Philips at philips.j.a@wustl.edu.


[Post Date: May 23, 2017]

Title: ERC Funded Postdoc Position

Description:
A 2.5 year ERC funded post-doctoral position is currently available in the group of Bert Janssen on a structural biology project concerning communication between cells in our nervous system.

You will use modern tools in structural biology; X-ray and cryo-EM, as well as biochemical, biophysical and cell biological techniques to characterize ligand receptor complexes that play a role in adhesion and intercellular signalling in our nervous system.

The lab is well-equipped to produce and study mammalian (membrane) proteins and is part of the Bijvoet Center for Biomolecular Research at Utrecht University. The Bijvoet Center is a dynamic hub of structural biology and provides access to excellent infrastructure and training.

We are looking for a highly motivated and talented researcher with a strong background in structural biology and/or biochemistry who is keen in working in an ambitious and multidisciplinary research team. Experience with cryo-EM will be considered a plus. Intended start date is flexible but preferably before 2018.

Candidates should send their CV, motivation letter and contact details of three references to b.j.c.janssen@uu.nl before Monday 19 June 2017.

Dr. Bert Janssen
Bijvoet Center for Biomolecular Research,
Utrecht University


[Post Date: May 23, 2017]

Title: Research Track Assistant Professor

Description:
Assistant Professor, Research Track - Department of Biophysics

The Structural Biology Laboratory at UT Southwestern Medical Center currently has two openings at the non-tenure track Research Assistant Professor level for highly-motivated individuals who enjoy working in a collaborative, multi-disciplinary setting.

· Position #1: Cryo-electron microscopist with extensive experience in high resolution single-particle reconstruction, including sample grid preparation, data collection, the use of modern software for particle picking and classification, map generation, model building and structure validation. Experience in cryo-EM tomography is a plus.
· Position #2: X-ray crystallographer with extensive experience in modern methods of crystallization, data collection using home and synchrotron sources, structure solution via various experimental techniques, refinement and structure validation.

For both positions, a Ph.D. in biochemistry, chemistry, physics or a related field is required. Facility with related techniques for each position such as cryo-electron microscopy, X-ray crystallography, NMR, small-angle X-ray scattering, isothermal titration calorimetry, analytical ultracentrifugation and protein expression and purification is highly desirable.

Job requirements include a significant amount of both formal and informal teaching, and teaching experience is highly desirable. Salary is competitive and commensurate with experience and qualifications.

About the UT Southwestern Structural Biology Laboratory
The Structural Biology Laboratory (Diana Tomchick, Director) is a platform that allows researchers with different expertise to come together in a collaborative setting and tackle biological problems in a comprehensive way. Our publications are representative of the success of this strategy: http://www3.utsouthwestern.edu/sbl/Publications.html

State-of-the-art equipment is currently installed, operational and shared between the members in the Structural Biology community at UT Southwestern. Cryo-EM equipment consists of one 300 kV Titan Krios microscope, one 200 kV Talos Arctica microscope, and a cryo-Scios DualBeam for cryo-FIB milling. In addition, the Structural Biology Laboratory has a dedicated lab for cryo-EM grid preparation, with an FEI Vitrobot and assorted instruments for sample prep. Computational facilities include a campus high-performance computing cluster. Crystallographic equipment includes an Art Robbins Gryphon crystallization robot and a Scorpion liquid handling robot, a Jansi UVEX UV microscope, a Rigaku FRE superbright rotating anode X-ray generator with an ACTOR sample mounting robot, and 30 days of guaranteed synchrotron beam time at Sector 19 of the Advanced Photon Source.

These facilities are supplemented by a variety of biophysical instruments supporting the study of macromolecules using NMR, CD, dynamic light scattering, analytical ultracentrifugation, stopped-flow kinetics, isothermal titration calorimetry, microscale thermophoresis and mass spectrometry.

Applicants should submit a curriculum vita and three letters of reference by July 10, 2017 to Diana Tomchick, Chair, Structural Biology Laboratory Search Committee, U.T. Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8816. UT Southwestern is an Affirmative Action/Equal Opportunity Employer. Women, minorities, veterans and individuals with disabilities are encouraged to apply.


[Post Date: May 22, 2017]

Title: Postdoc University of Bergen
Website: https://www.jobbnorge.no/en/available-jobs/job/138528/postdoctoral-fellow-3-years

Description:
Postdoctoral Fellow at the University of Bergen (Norway) for structure-based design of riboswitch ligands.

Experience in at least two of the following topics:

• Structure-based ligand design
• X-ray crystallography of macromolecules
• SPR or BLI
• In vitro transcription of RNA
• Fragment screening
• Development of binding assays


[Post Date: May 22, 2017]

Title: Research Associate / Assistant Professor

Description:
Research Associate/Assistant Professor positions are immediately available in Prof. Wilson’s Lab of Antibody Structure at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University (http://siais.shanghaitech.edu.cn/eng/research7.asp). SIAIS is an innovative research institute dedicated to the fundamental problems in life science, particularly in the field of immunology.

The Lab of Antibody Structure utilize a multidisciplinary approach to study the structures and functional mechanisms of key molecules/complexes in innate and adaptive immunity, with a long-term goal of understanding and modulating the functions of important immune receptors and effectors for the prevention and treatment of various immune disorders, microbial infections or cancers.

We are now seeking self-motivated talents to join us. Candidates for Research Associate/Assistant Professor positions should:

--- hold a Ph.D. degree in biophysics, biochemistry, computational biology or immunology

--- have a strong research background in structural or computational biology

--- have a publication record commensurate with experience

--- manifest good problem solving, interpersonal and communication skills

--- experience in protein expression/purification and some background in membrane protein crystallography would be a plus.

--- experience in ITC/Biacore/DSC instrumentation is also a plus, as well as familiarity with small angle x-ray scattering (SAXS)

Besides taking responsibilities for his/her own and collaborative projects, the candidates are also expected to help training and supervising graduate students and postdoctoral fellows. The candidates will benefit from the world-class academic environment as well as easy access to SSRF beamlines for macromolecules and SAXS, and state-of-the-art cryo-EM instruments (Titan Krios/K2 to be installed at ShanghaiTech University).

If interested, please send a cover letter, a curriculum vitae with publication list and three references to siais@shanghaitech.edu.cn (cc: wilson@scripps.edu and yangbei@shanghaitech.edu.cn). Title and Salary will be commensurate with experience. The positions remain open until filled.


[Post Date: May 19, 2017]

Title: Research Engineer BioMAX

Description:
Research engineer BioMAX
Lunds universitet, MAX IV, Diffraction & Scattering
Lund University was founded in 1666 and is repeatedly ranked among the world’s top 100 universities. The University has 42 000 students and 7 400 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.
MAX IV is a national large-scale research laboratory providing scientists from Sweden and the rest of the world with instruments for research in areas such as materials science, structural biology, chemistry and nanotechnology. Fully developed it will receive more than 2 000 scientists annually. 200 people are currently employed at the MAX IV Laboratory.
BioMAX is the first macromolecular crystallography beamline at the new ultimate storage ring MAX IV. The beamline has been designed to deliver an energy tunable, high brilliant, microfocused x-ray beam at micrometer size and to support the majority of techniques in the field for crystals down to the micrometer range. A fast x-ray detector in combination with a high capacity sample changer is enabling very efficient data collection schemes.
BioMAX has been recently set into operation. Nevertheless, to reach the anticipated performance level within the coming year, substantial commissioning and optimization tasks are still pending.
In order to develop, to operate and to maintain BioMAX, we are now seeking to hire a research engineer with a background and interest in X-ray synchrotron radiation based techniques and instrumentation.
Tasks

• You will participate in the commissioning of the beamline and its end-station.
• You will share responsibilities for operation, maintenance and further development of the beamline in close collaboration with the team of scientists and engineers of the MX-group and MAX IV staff.
• You will develop strategies for diagnostics and controls of the BioMAX technical infrastructure.
• You will share responsibility for the support of external users during their beamtime.
• You will contribute to the design, the purchase and the installation of new beamline and experimental station components to ensure the availability of a competitive and reliable beamline environment.
• You will work on the design of the new micro-focusing beamline MicroMAX.

Note: The amount and nature of the participation in user support will depend on the interests and the profile of the successful candidate.

Qualifications

The following qualifications are required:

• You hold a university degree in engineering or natural sciences in subjects of relevance for BioMAX.
• You have a solid background and knowledge in mechatronics.
• You have a solid experience in the planning, design/construction/purchase, operation and maintenance of complex scientific equipment in particular such equipment that is of relevance for BioMAX.
• You have experience with programing / interfacing of hardware.
• You have a solid knowledge and experiences in instrumentation controls hardware and software.
• Experience with programing / interfacing of hardware.
• You have a demonstrated ability to work independently.
• You have excellent command of English, well-developed communication skills and team working skills.

The following qualifications are considered an asset:

• Experience in the design, commissioning, and use x-ray hardware.
• Demonstrated knowledge of X-ray instrumentation and associated techniques.
• Experience with vacuum and cryogenics technologies.
• Experience of developing, assembling, running, and maintaining equipment for x-ray techniques.
• Interest/experience in scientific use of techniques of interest for BioMAX (i.e. experiments, data analysis, publication / presentation of results).

Experience with support of user groups at a synchrotron radiation facility or a similar user-oriented research facility is a further merit.
Probationary period may be applied.

Lund University welcomes applicants with diverse backgrounds and experiences. We regard gender equality and diversity as a strength and an asset.
We kindly decline all sales and marketing contacts.
Type of employment Permanent position
Contract type Full time
First day of employment As per agreement
Salary Monthly salary
Number of positions 1
Working hours 100 %
City Lund
County Skåne län
Country Sweden
Reference number PA2017/1219
Contact • Uwe Müller, +46 73065268
Union representative • OFR/S:Fackförbundet ST:s kansli, 046-222 93 62, st@st.lu.se
• SACO:Saco-s-rådet vid Lunds , 046-222 93 64, kansli@saco-s.lu.se

Published 18.Apr.2017
Last application date 31.May.2017 11:59 PM CET


[Post Date: May 19, 2017]

Title: Postdoc University of Edinburgh
Website: https://www.vacancies.ed.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.jobspec?p_id=039927

Description:
A postdoctoral position is available in Jeyapraksh (JP) Arulanandam’s lab at the Wellcome Centre for Cell Biology, University of Edinburgh. The JP lab (http://jeyaprakash.ed.ac.uk) aims to understand the structural level mechanistic details of processes regulating error-free chromosome segregation. The successful candidate will combine protein biochemistry and structural biology with mammalian cell based assays to dissect the molecular details of how specific intermolecular protein interactions achieve stable centromere maintenance and accurate chromosome segregation during cell division.

Applicants must have (or will shortly be awarded) a PhD with training in biochemistry, structural biology and cell biology. The successful candidate will be a highly motivated and enthusiastic individual with an outstanding academic track record, good communication skills and the ability to work as a team. Applicants with experience in single particle cryoEM, biochemistry and mammalian cell based siRNA/CRISPR rescue assays are encouraged to apply.

The post is for 12 months in the first instance with the possibility of extension.

Closing Date: 16 June 2017 at 5pm GMT

For further particulars and to apply for this post, please follow https://www.vacancies.ed.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.jobspec?p_id=039927


[Post Date: May 18, 2017]

Title: Associate Researcher
Website: https://employment.ku.edu/staff/8691BR

Description:
The Protein Structure Laboratory at the University of Kansas is seeking a full-time Associate Researcher to assist with various structural biology projects. For a full description and to apply, GO TO: https://employment.ku.edu/staff/8691BR

Review of applications begins 5/30/17


[Post Date: May 17, 2017]

Title: Industry-Academia Research Fellow

Description:
Industry-Academia Research Fellow positions
Monash University, Australia

Department of Biochemistry and Molecular Biology
Infection & Immunity Program
Biomedicine Discovery Institute
Faculty of Medicine, Nursing and Health Sciences

The opportunity:
Several post-doctoral fellowships are available at Monash University to undertake translational research in Immunity that is supported by Janssen Pty Ltd. The fellowships will provide opportunities for the candidates to interact with industry leaders and gain insights into drug discovery and development in the pharmaceutical industry. The researchers will be aiding the development of novel therapies to treat rheumatoid arthritis. These collaborative research activities have significantly expanded over the course of past few years, and the successful applicants will be a core part of a large team of researchers working in rheumatoid arthritis and adaptive immunity.

The industry-academia alliance:
Since 2015, the Rossjohn laboratory and Janssen-Cilag Pty Ltd. (Janssen), one of the Janssen Pharmaceutical companies of Johnson & Johnson, have forged a collaboration centred on developing novel therapeutics for rheumatoid arthritis. This collaborative partnership leverages the world leading expertise of the Rossjohn laboratory at Monash University with the innovative expertise of Janssen to discover and develop novel approaches for the treatment of autoimmune diseases. A major focus of the current collaboration is to explore opportunities in early disease interception including fundamental mechanisms related to breakdown of tolerance. These objectives are strategically aligned with the Immunology Therapeutic Area (TA) of Janssen R&D.

Infection and Immunity Program,
The Department of Biochemistry and Molecular Biology,
Biomedicine Discovery Institute, Faculty of Medicine,
Nursing and Health Sciences Monash University, Clayton

The Rossjohn laboratory, is located at the Clayton Campus, Monash University, Australia. The laboratory is focused on understanding the molecular correlates of T-cell immunity, both in the context of protective immunity and dysfunction, including T cell autoimmunity. For more details on the research themes, fellowships awarded and publication outputs see: http://research.med.monash.edu.au/rossjohn/

Janssen, a global pharmaceutical company, specialises in the discovery, development, manufacturing and commercialization of therapies for autoimmune disease. Janssen brings overall project oversight through the involvement of senior leaders, Dr. Daniel Baker (Disease Area Leader, RA), Dr. Anish Suri (Senior Director, Janssen Immunosciences) and Kathy Connell (Director of New Ventures, Australia and NZ). They will be responsible for integrating research and business strategies, directing development strategy in RA and developing project outcomes to commercialisation.

For more details on Janssen see: http://www.janssen.com/australia/

The role: Prof. Jamie Rossjohn, ARC Australian Laureate Fellow, is seeking highly motivated and talented research fellows to join the research group. The selected candidates, with expertise either in protein chemistry, molecular biology of T cell biology, will work in the field of Rheumatoid Arthritis.

Applicants should hold a PhD in Biochemistry, Molecular Biology or T-cell Immunology. Experience in a number of the following areas would be an advantage:
1) Molecular Biology: particularly including phage and/or yeast library display, library production and screening, affinity maturation of receptors;
2) Protein Biochemistry- production, purification and analysis: E. coli, yeast, insect cells and/or mammalian expression systems (including cell culture techniques), chromatography, crystallography, proteomics (particularly mass spectrometry);
3) Cellular Immunology: tissue culture and flow cytometry;
4) Autoimmune-based animal models of human diseases

Candidates with a promising track record in the relevant areas and a proven publication record in international journals are encouraged to apply.

Appointment will be made at a level appropriate to the successful applicant’s qualifications, experience and in accordance with classification standards for each level.

Salary range: Level A $81,486- $87,471 and Level B $92,074 to $109,339

Duration: The position is available for up to 3 years
Location: Clayton Campus

Contact: Dr. Jennifer Huynh, Jennifer.Huynh@monash.edu
Closing Date: June 22, 2017


[Post Date: May 17, 2017]

Title: Postdoc Monash University

Description:
Postdoctoral Research Fellow position
Monash University, Australia

Department of Biochemistry and Molecular Biology
Infection & Immunity Program
Biomedicine Discovery Institute
Faculty of Medicine, Nursing and Health Sciences

The laboratory: The Rossjohn laboratory, as part of a broad collaborative network that includes lead national and international researchers, has provided profound insight into T-cell immunology, specifically defining the basis of key immune recognition events by T-cells. The laboratory has notably pioneered our understanding of lipid-based immunity and the role of MAIT cells in recognizing vitamin B metabolites.

The role: In collaboration with Prof. Anthony Purcell’s laboratory, we are seeking a highly motivated and talented post-doctoral scientist to join the research groups. The selected candidate will work in the areas of lipid- and metabolites-mediated immunity. You will be responsible for investigating the detection of lipid- and metabolites-based antigens in immunity using mass spectrometry. For more information:
http://research.med.monash.edu.au/rossjohn/ http://www.med.monash.edu.au/biochem/staff/purcell.html

Postdoctoral research positions: the applicant should hold a PhD in Biochemistry with significant experience in the field of proteomics and mass spectrometry. Candidates with a promising track record in the relevant areas and a proven publication record in international journals are encouraged to apply. Appointment will be made at a level appropriate to the successful applicant’s qualifications, experience and in accordance with classification standards for each level.
Salary range: Level A $ 81,486 - $ 87,471
Level B $ 92,074 - $ 109,339

Duration: The position is for 1 year in the first instance.
Location: Clayton Campus, Australia

Contact: Send one page cover letter and a full CV as a single pdf file to jerome.lenours@monash.edu and Anthony.Purcell@monash.edu.

Closing Date: June 1st, 2017


[Post Date: May 17, 2017]

Title: Senior Support Scientist Diamond Light Source

Description:
We are seeking to recruit a Senior Support Scientist to join the B24 cryo X-ray tomography team.

The post holder is expected to help with the operation and development of the beamline through contributing to user support, participation in the in-house research and development programme and general house-keeping tasks (instrument support, maintaining webpages and up keep of beamline documentation).

The post holder is also expected to aid in the design, construction, installation and commissioning of beamline modules.

Candidates should ideally have an excellent understanding of current biomedical research requirements, experience in cellular microscopy (preferably cryo-microscopy of biological samples) and be familiar with synchrotron radiation beamlines. Experience in fluorescence microscopy as well as life science research (tissue culture, sample handling and processing) and logistics is desirable. Training will be provided where necessary.

You can find further information at http://www.diamond.ac.uk/Careers/Vacancies/All/050_17_CH.html

This is a 2 year fixed full time post and the application deadline is the 11th of June, 2017.


[Post Date: May 16, 2017]

Title: Postdoc The Institute of Cancer Research

Description:
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment. Under the leadership of our Chief Executive, Professor Paul Workman FMedSci, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The Cancer Therapeutics Unit’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the scientific disciplines are in place to make this possible, including medicinal chemistry, biology, drug metabolism and clinical specialists who focus on new molecular targets emerging from human genome and ground breaking cell biology research.

A postdoctoral position is now available in the Hit Discovery and Structural Design Team within the CTU (Ref. 1646606). The team combines assay development and small-molecule high-throughput screening with fragment-based hit discovery, biophysical assays and X-ray crystallography. These methodologies are underpinned by state-of-the art protein expression, purification and protein characterisation capabilities allowing the generation of large quantities of high quality recombinant proteins. The successful candidate will work on an exciting early stage target in CTU’s drug discovery portfolio. The postdoctoral training fellow will establish the successful expression, purification and characterisation of the protein target, using contemporary expression systems, including insect and mammalian cells, and purification methods available within the team. They will establish the in-house crystallisation and structure determination and subsequently carry out the structural determination of protein-inhibitor complexes. In addition, the post-holder is expected to initiate the development of biochemical and biophysical assays to characterise the protein target and to establish compound screening assays. The successful candidate will be an integral member of a multidisciplinary project team and will interact closely with the biologists, computational chemists, medicinal chemists and structural biologists and will therefore be expected to work across the two sites in Chelsea, London and Sutton, Surrey.

Applicants must have a PhD in a biological or physical science, and experience in macromolecular crystallography (to include protein biochemistry, protein crystallisation, & protein crystallography). Experience in insect cell/mammalian cell expression, assay development, and/or biophysics will be highly advantageous. The starting salary for this position will be up to £35,538p.a. inclusive (based on previous experience) and the post is offered on a fixed term contract of 1 year.

Further information about these positions can be found in the full job description at www.icr.ac.uk. Informal enquiries to rob.vanmontfort@icr.ac.uk - but applications must be submitted on-line (www.icr.ac.uk). Closing date is June 11th.


[Post Date: May 16, 2017]

Title: Lecturer Position in Bioprocessing
Website: http://www.ul.ie/hrvacancies/

Description:



Lecturer below the bar in Bioprocessing

The University of Limerick (UL) with over 13,000 students and 1,300 staff is an energetic and enterprising institution with a proud record of innovation and excellence in education, research and scholarship. The dynamic, entrepreneurial and pioneering values which drive UL’s mission and strategy ensures that we capitalise on local, national and international engagement and connectivity. We are renowned for providing an outstanding student experience and conducting leading edge research. Our commitment is to make a difference by shaping the future through educating and empowering our students. UL is situated on a superb riverside campus of over 130 hectares with the River Shannon as a unifying focal point. Outstanding recreational, cultural and sporting facilities further enhance this exceptional learning and research environment.
Applications are invited for the following position:

Faculty of Science + Engineering
School of Natural Sciences
Department of Chemical Sciences

Lecturer below the bar in Bioprocessing Contract Type: Tenure Track (five year fixed term). During the term of the contract the successful applicant will have the opportunity to apply for tenure in accordance with the University's Policy and Procedures for Granting Multi-annual Status to Entry-level Academic Staff
Salary Scale: €38,348 - €52,722 p.a.

Further information for applicants and application material is available online from: http://www.ul.ie/hrvacancies/

The closing date for receipt of applications is Friday, 2nd June 2017.
Applications must be completed online before 12 noon, Irish Standard Time on the closing date.

Please email erecruitment@ul.ie if you experience any difficulties

Applications are welcome from suitably qualified candidates.

The University is an equal opportunities employer and committed to selection on merit.


[Post Date: May 15, 2017]

Title: Professor/Reader in Structural Biology
Website: http://www.jobs.ac.uk/job/BBG425/professor-reader-in-structural-biology-chemical-biology-ac7037ml/

Description:
Structural biology in St Andrews is based in a large shared purpose-built laboratory, capable of hosting ~40 researchers. This space is currently shared with the Gloster, Schwarz-Linek, Taylor and Pliotas groups. The laboratory has great facilities for protein biochemistry (incubators, floor centrifuges), crystallisation (Gryphon crystallisation robot for dispensing nano-drops and Scorpion robot for mixing crystallisation screens), crystal visualisation (two crystallisation incubators and Minstrel robot for automated crystal imaging), and in-house crystal testing (Rigaku generator with two CCD detectors; one robotically controlled). Crystallographers have regular access to BAG synchrotron time, both at Diamond and ESRF, which is shared with users in Dundee. St Andrews provides an excellent mass spectrometry/proteomics facility for protein identification and more complex analyses. Solution state biomolecular NMR is supported by a dedicated 700 MHz instrument (Bruker Ascend, Prodigy TCI cryoprobe). Structural biology is also supported by a uniquely powerful EPR setup (X, Q, W band); St Andrews hosts the two most sensitive pulse EPR spectrometers in the UK. A new biophysics suite provides ITC (Microcal PEAQ and VP), SPR (Biacore T200), CD, and stopped-flow machines. There are also dedicated rooms for insect and mammalian cell culture, with hoods and large incubators containing shaking platforms for protein expression.


[Post Date: May 12, 2017]

Title: Postdoc Institut Curie Paris

Description:
Job title: Postdoctoral Research Assistant (molecular motors)
Job location: Institut Curie, Paris, France
Job closes: 21-June-2017

A post-doctoral researcher position is available in the Structural Motility laboratory directed by Anne Houdusse to undertake research on molecular motors. In collaboration with cell biologists and biophysicists, the project aims at understanding the precise cellular role of cytoskeleton motors important for tumour proliferation using a combination of state-of-the-art cell biology, biochemistry and structural biology. The studies are a collaborative effort between the laboratories of the structural biologist Anne Houdusse, expert in molecular motors and the cell biologists Phong Tran and Bruno Goud, both from the same department (UMR 144) at Curie Institute.

The successful applicant is expected to employ state-of-the-art structural biology, cell biology and biophysical approaches to conduct molecular and structural studies on disease-relevant human molecular motors.

I am looking for enthusiastic, self-motivated Ph.D. graduates with a strong publication record and expertise in molecular biology, biochemistry, X-ray crystallography or electron microscopy who will welcome working in an interdisciplinary group with a friendly atmosphere and excellent resources. Experience with structure determination by crystallographic methods or EM is a must. Please send a CV, a one-page research experience summary and contact information of three references to anne.houdusse@curie.fr. Please write “Post-doctoral position” in the subject header.


[Post Date: May 11, 2017]

Title: Postdoc Riken Japan

Description:
We are seeking a highly motivated and experienced computational structural biologist to join the Structural Bioinformatics Team, Center for Life Science Technologies at RIKEN, Japan. The successful candidate will develop computational methods and tools to enable the automated structure determination from and the efficient structure refinement based on cryo-EM maps. Please visit http://www.riken.jp/zhangiru/ for details of our research activities.

This position requires a PhD in computer science, biophysics, biochemistry, chemistry, bioinformatics, structural biology or related discipline with experience in employing computational tools to solve biological or chemical problems. Experience in cryo-EM based structure determination and related method development is highly desired. Proficiency in object-oriented programming and scripting languages are also required. Experience in parallel computing on supercomputers would be a plus. The ideal candidate should possess a track record of accomplishments demonstrating technical proficiency, independent thinking, and scientific creativity. The research environment in the team is international and English will be used for communication and knowledge of Japanese is not required.

For more information on job description and how to apply, please visit
http://www.riken.jp/en/careers/researchers/20170331_2/

For inquiries:
Dr. Kam Zhang
Structural Bioinformatics Team
Division of Structural and Synthetic Biology
Center for Life Science Technologies
RIKEN
1-7-22 Suehiro, Tsurumi, Yokohama
Kanagawa 230-0045,
Japan
kamzhang@riken.jp
http://www.riken.jp/zhangiru/


[Post Date: May 11, 2017]

Title: Postdoc

Description:
Postdoctoral Research Associate in Gene Regulation

We are seeking to appoint an enthusiastic individual as a Postdoctoral Research Associate to join dynamic research group in Oxford to lead a multidisciplinary project investigating the role of transcription factors as well as chromatin modifying enzymes in gene regulation. The proposed projects will utilize state-of-the-art biochemical and structural approaches, combined with the functional genome-wide analysis, to understand how transcription of protein-coding and non-coding genesis is regulated in yeast and mammalian cells.

Applicants should possess a PhD, or expect to obtain soon, a PhD in a relevant subject area, and should have experience in expression and purification of recombinant and native protein complexes. Experience with biochemistry is essential, as well as excellent communication skills, including the ability to write for publication, present research proposals and result. Experience with mammalian cell culture and bioinformatics would be advantageous.

This full-time fixed-term post is funded by the Wellcome Trust Senior Research Fellowship for up to 1 year in the first instance, and is based at the Department of Biochemistry, South Parks Road, Oxford, OX1 3QU.

This position is graded on the University's grade 7 scale, for which the salary range is £31,076 - £38,183 per annum. The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available.

For further general information, phone (01865) 613204, quoting reference number 128878.

Applications for this vacancy are to be made online.
To apply for this role and for further details, including the job description and selection criteria, please click on the link below:

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_details_form.jobspec?p_id=128878

The closing date for applications is 12.00 noon on Wednesday 7 June 2017, with interviews for shortlisted candidates to be held as soon as possible thereafter.

The University of Oxford is a member of the Athena SWAN Charter and holds an institutional Bronze Athena SWAN award. The Department of Biochemistry is strongly committed to equality and valuing diversity and we operate a flexible working policy for all staff. The Department holds a departmental Silver Athena award in recognition of its efforts to introduce organisational and cultural practices that promote gender equality and create a better working environment for both men and women. Committed to equality and valuing diversity.


[Post Date: May 11, 2017]

Title: Postdoc NIH

Description:
Postdoctoral position in small molecule screening and mechanistic studies with membrane proteins at the NIH

The research group of Dr. Anirban Banerjee at the National Institute of Health (NIH) is seeking candidates for postdoctoral fellows to start immediately. The broad interests of the lab are in membrane protein structure and function. We are combining structural techniques such as macromolecular crystallography with biophysical and biochemical methods such as reconstitution based functional assays to investigate the structural bases of the mechanisms of integral membrane enzymes and transporters.

For this position, we are looking for a candidate who will carry out both structural studies and biochemical experiments on a biomedically important but functionally understudied integral membrane protein family. Besides understanding the structural and chemical basis of function, one of our long term goals is also to explore using structural information and high throughput assays to discover novel small molecule ligands for this protein in collaboration with other labs at the NIH

The DC Metro area is a wonderful place to live, the weather is pleasant and the NIH is a vibrant international community. In terms of scientific opportunities, the NIH is absolutely unique in bringing scientists from virtually all areas of biomedical sciences in one campus. Our lab is part of the Cell Biology and Neurobiology Branch in the National Institute of Child Health and Human Development (NICHD). Our lab also has an affiliation to the National Institute of Neurological Disorders and Stroke (NINDS). We interact with several other labs at the NIH who are interested in structural biology and membrane proteins.

Qualifications
The candidates should hold a Ph. D. degree, be author of at least one first author publication and have a strong background in biochemistry or structural biology. Experience with basic molecular biology, protein expression, purification and biochemical characterization are required. Prior experience in membrane protein biochemistry or insect/mammalian expression systems will be added advantages.
Interested candidates can send an email of interest to anirban.banerjee@nih.gov with a CV and a summary of previous research experience and interests.



[Post Date: May 11, 2017]

Title: Postdoc MRC Laboratory of Molecular Biology

Description:
Postdoctoral Research Position in Structural Biology of DNA damage response

Starting Salary £30,162 to £32,975 per annum
MRC Laboratory of Molecular Biology, Cambridge UK

The phosphoinositide 3-kinase-like protein kinases ATM and ATR are key enzymes signaling cellular responses to double and single-stranded DNA breaks. A postdoctoral position is available for structural biology of the complexes that these kinases make with substrates, adaptors, regulatory subunits and DNA. This two-year AstraZeneca funded position involves electron cryo-microscopy (cryo-EM), hydrogen/deuterium exchange mass spectrometry (HDX-MS), X-ray crystallography, biochemistry and cell biology.

The work will be carried out in the research group of Roger Williams in the MRC Laboratory of Molecular Biology (LMB). The LMB has state-of-the-art facilities for cryo-EM, HDX-MS and X-ray crystallography, as well for a wide range of other biophysical approaches.

Candidate requirements
Applicants should have a Ph.D. in biology, biochemistry, biophysics, chemistry or a related discipline or, exceptionally, equivalent experience and a strong interest in structure-function studies of the DNA damage response. Experience in cryo-EM, HDX-MS, X-ray crystallography or biochemistry would be particularly useful, however, motivation and innovation are essential.

The successful applicant will be awarded a 2 year Career Development Fellowship/MRC Postdoctoral Training Scheme with a potential 3rd year extension following assesment by the funder. The fellowship is a training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, or is moving into a new research discipline.
Working for the MRC provides a whole host of benefits including a final salary pension scheme, Benenden Healthcare membership and excellent holiday entitlement. You will also have access to employee shopping/travel discounts, on site sport and social facilities, as well as salary sacrifice cycle to work schemes and childcare vouchers.

The MRC Laboratory of Molecular Biology is one of the birthplaces of molecular biology and is an internationally renowned centre for fundamental biomedical research. The LMB has an excellent record of innovative basic research leading to applications in medicine. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.
For further information of the research undertaken at the LMB, please visit http://www2.mrc-lmb.cam.ac.uk or contact Roger Williams (rlw@mrc-lmb.cam.ac.uk).


[Post Date: May 11, 2017]

Title: Postdoc CSIRO
Website: https://career10.successfactors.com/sfcareer/jobreqcareer?jobId=39270&company=CSIRO&username

Description:
CSIRO Postdoctoral Fellowship in Structure Based Drug Design

Utilise your skills in Biophysical techniques
Collaborate with world leading, dedicated professionals in virology, molecular/cell biology & protein chemistry
Join a multi-disciplinary team at the forefront of anti-viral strategies

The Position

CSIRO Postdoctoral Fellows provide opportunities to scientists and engineers, who have completed their doctorate and have less than three years relevant postdoctoral work experience. These fellowships will help launch their careers, provide experience that will enhance their career prospects, and facilitate the recruitment and development of potential leaders for CSIRO.

Applications are invited for a 3 year CSIRO Postdoctoral Fellowship in CSIRO Manufacturing. You will be involved in fragment screening and structure based drug design of new antivirals. You will join a cross-disciplinary team with expertise in virology, molecular/cell biology and protein chemistry to develop novel antivirals based around the disruption this enzyme.

Specifically you will:

Under the direction of senior research scientists, carry out innovative, impactful research of strategic importance to CSIRO that will, where possible, lead to novel and important scientific outcomes.
Express, purify and characterise anti-viral target protein(s); perform fragment based screening and further exemplify lead molecules.
Contribute to a team effort to assess the antiviral properties of lead molecules and to define the role of the cellular enzyme(s) in the virus infection cycle.
Undertake regular reviews of relevant literature and patents.
Produce high quality scientific papers suitable for publication in quality journals and granting of patents.

Location: Parkville, Melbourne, VIC, Australia
Salary: AU$78K - AU$88K plus up to 15.4% superannuation
Tenure: 3 year specified term
Reference: 39270

For more details about this exciting opportunity click on the position details link: Position Details

To be successful you will need:

A doctorate (or will shortly satisfy the requirements of a PhD) in a relevant discipline area, such as Structural Biology, Biophysics, Biochemistry.
Demonstrated experience in protein expression, protein purification and the biophysical characterisation of proteins.
A background / experience in Biophysical techniques such as X-ray crystallography, Surface Plasmon Resonance, or NMR.
The ability to work effectively as part of a multi-disciplinary, regionally dispersed research team, plus the motivation and discipline to carry out autonomous research.
A record of science innovation and creativity, plus the ability & willingness to incorporate novel ideas and approaches into scientific investigations.

Owing to the terms of the fellowship, candidates must not have more than 3 years of relevant full time postdoctoral experience.

Who we are: The Commonwealth Scientific and Industrial Research Organisation (CSIRO)

At CSIRO we invent the future. We do this by using science and technology to solve real issues. Our solutions make a difference to industry, people and the planet. As Australia’s national science agency we’ve been pushing the edge of what’s possible for almost 90 years. Today we have thousands of talented people working across Australia and internationally. Our people work closely with industry and communities to leave a lasting legacy. Collectively, our innovation and excellence places us in the top ten applied research agencies in the world. We Collaborate to Innovate.

How to Apply: To apply for this position please include with your CV/Resume and a statement addressing the essential criteria, and any other information that is relevant to the position. Please upload these as one document.

Applications close: 13 June 2017 (11:59pm AEST)


[Post Date: May 09, 2017]

Title: Postdoc Stockholm University

Description:
Postdoctoral position in membrane protein structural biology
The laboratory of David Drew at Stockholm University is seeking an enthusiastic postdoc with an interest in elucidating molecular mechanisms of brain transport proteins using biochemical and biophysical approaches. We use diverse techniques to address brain transporter function, and use both X-ray crystallography and cryoEM for structural studies. Our department is equipped with a Talos Artica and Titan-Krios/K2 EM microscopes and has excellent support staff. The candidate should either hold or expect to hold a Ph.D. in the area of biochemistry or neurochemistry, with expertise in either cryoEM or X-ray crystallography. Expertise in mammalian cell culturing, and expression and purification of protein complexes would be advantageous. The Postdoc position is initially for 2 years with a possibility of extension. Please visit the lab website (http://www.su.se/english/profiles/drew-1.181696) before you apply and send your CV with a brief research statement as well as 2-3 contacts for references to ddrew@dbb.su.se before the 10th June.


[Post Date: May 09, 2017]

Title: Postdoc Fox Chase Cancer Center

Description:
A postdoctoral position is available at Fox Chase Cancer Center (Philadelphia, PA) for a highly motivated individual in the field of protein biochemistry, cell signaling, or structural biology.

The lab aims to understand the molecular basis for the cell signaling events that affect cell motility. The candidate should have strong experiences in protein biochemistry, molecular biology, and structural biology. Prior experiences in mammalian cell culture and confocal imaging are desired but not required. The candidate should obtain a Ph.D. degree in a related field in the last three years.

Fox Chase Cancer Center is a long-standing NCI-designated Comprehensive Cancer Center with multidisciplinary research interests from basic biological sciences to drug development and clinical studies. The research institute at FCCC is one of the top-ranked work places for postdoctoral researchers. It offers an outstanding research environment and strong support for career development.

Please send a cover letter describing previous research experience and current interests, an updated CV, and a list of three references to: Jinhua.wu(at)fccc.edu.


[Post Date: May 09, 2017]

Title: Crystallography Group Scientist/Senior Scientist

Description:
Immunocore LTD are looking to recruit for the newly formed Crystallography Group. You will be part of a small research team that aims to improve our understanding of T Cell Receptor (TCR) structure function relationships to enhance our understanding and development of our novel platform of TCR based therapeutics.

To be successful in the role you will
o Be experienced in all aspects of the crystallography workflow (including protein purification, crystallisation, data collection, processing and analysis of x-ray diffraction data and model building).
o Be passionate about using structural data to influence key scientific decisions. This will involve interpreting crystal structures in the context of available biophysical and cellular data and communicating key findings to colleagues from diverse scientific backgrounds.
o Have a good working knowledge of linux operating systems.
Application closing date: 31st May 2017 application closing date

For more details:

http://www.immunocore.com/careers/view/crystallography-group-scientistsenior-scientist


[Post Date: May 09, 2017]

Title: Research Technician
Website: http://www.jobs.ac.uk/job/BBD342/research-technician

Description:
One Research technician position is immediately available in the Berger laboratory, University of Bristol UK.

The Berger laboratory researches the structure and mechanism of key multiprotein complexes in human gene expression and develops enabling methods for their study.

We are seeking a Research Technician to actively participate in the ambitious research projects in our laboratory. The successful candidate will engage in designing and preparing DNA constructs, and will express, purify and characterize proteins and their complexes for high-resolution structural and functional study. Showing a high level of organization and independence, the successful candidate will manage the molecular biology and protein purification platforms including ordering of consumables, and assist in operating the eukaryotic expression facility in the Berger lab.

The role holder will work under the supervision of the PI and will actively embrace the responsibility of managing technology platforms underpinning all research in the Berger lab.

For further information follow link: http://www.jobs.ac.uk/job/BBD342/research-technician


[Post Date: May 05, 2017]

Title: Research Technician Structural Biology

Description:
Research Technician Position in Structural Biology at CNIO (Spanish National Cancer Research Centre, Madrid, Spain)

A 3 years NIH-funded research technician position is immediately available for a highly motivated structural biologist in the Crystallography and Protein Engineering Unit at the CNIO’s Structural Biology and Biocomputing Programme.

The Unit provides state-of-the-art infrastructures for protein production and posterior structural studies, which includes high-throughput protein crystallization instrumentation.

The successful applicant will be involved in a number of drug discovery projects that involves all the stages that lead to the determination of protein structures in the presence of inhibitors for further development. The candidate must have a strong background in molecular biology, protein expression/purification, X-ray crystallography and SAXS. Interested candidates should email personal@cnio.es (Reference TSCPE) with a cover letter describing the candidate's previous work experience and research interests, CV, and contact details of three referees.

Further details on how to apply can be found here:
http://www.cnio.es/ing/empleo/ofertas-amp.asp?codigo=1895


[Post Date: May 05, 2017]

Title: Postdoctoral Associate University at Buffalo
Website: https://www.ubjobs.buffalo.edu/postings/6006

Description:
Postdoctoral associate for the structure and function of vitamin D related cytochromes P450. Applicants with a background in protein crystallography or membrane protein production are especially encouraged to apply. More details on the position can be found here: https://www.ubjobs.buffalo.edu/postings/6006, or by searching job posting #R1700001.


[Post Date: May 05, 2017]

Title: Research Scientist Positions

Description:
The Position- Senior Principal Scientist - Chemical Biology Roche China, Shanghai

We are seeking a motivated and experienced scientist to lead our Biophysics/Biostructure/Protein chemistry Group in the department of Chemical Biology Department at Roche Innovation Center Shanghai. You will play leading roles in target validation, hit identification, hit validation and MoA study in drug discovery process. Your responsibilities include following fields:

• Lead a multidisciplinary functional group. Provide leadership and technical expertise in the areas of biophysics, biostructure and protein chemistry. Design and execute the strategy and plan for further development of the existing group. Recruit and train scientists and associates in experiment design, data management and analysis. Direct research scientists to ensure program efficiency.

• Deliver results with impact to project teams. Design and supervise protein chemistry efforts to support assay development and biostructure studies. Design and supervise biophysical and biostructural studies on molecular targets and mechanism of actions. Facilitate structure-based drug design and fragment-based drug discovery. Work with biologists, medicinal chemists and computational chemists to analyze structural information, understand the structure-function relationship of drug targets and address disease-related biological questions. Plan, supervise, multitask and direct projects to completion. Ensure timelines are met; communicate program objectives to cross-functional teams.

• Maintain high visibility for team and department. Act in the role of Chemical Biology Lead member of project teams. Provide critical leadership and steering to projects from the perspective of Chemical Biology. Build novel technologies in protein expression, purification, biophysics and biostructure. Actively direct research for opportunities to publish the results and strive for high impact opportunities.

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

• Educational qualifications and Professional competence: Ph.D. in biochemistry, biophysics, structural biology or related field with at least 8 years pharmaceutic/biotech research experience. Proficient in the scientific and technical backgrounds of protein chemistry methods and biophysical methods such as crystallography, cryo-EM, LC-MS, SPR, ITC, DLS and MST. Knowledge in CADD or enzymology or immunology/inflammation is a strong plus.

• Demonstrated Team Leadership Competencies: Excellent organizational and communicational skills and ability to establish/maintain working relationship. Demonstrated strong ability to supervise several reports including Ph.D. and MS level scientists.

• Project leadership competencies: Excellent communication skills as well as an ability to work in a multi-function team. Demonstrated proven experience, and an innate sense of urgency, in managing projects. Ability to deal with multitasking, appreciation of priorities and critical factors.
The Position- Senior Scientist, Protein Structure and Design
The Position Senior scientist in Biophysics/Biostructure/Protein chemistry group in Chemical Biology Department at Roche Innovation Center Shanghai. We are seeking a motivated scientist in the area of protein chemistry and biophysics. You will play key roles in target validation, hit identification, hit validation and MoA study in drug discovery process. Your responsibilities include following fields:

• Coach and develop associates in experiment design, data management and analysis.

• Design, express, purify, and characterize proteins of therapeutic interest.

• Design and perform biophysical assays such as thermal shift assay, SPR and ITC studies as a part of integrated screening to characterize protein-ligand, protein-protein, protein-nucleic acid interactions.

• Involved in designing critical enzymatic assays to address mechanistic questions and facilitate hit qualification; involved in designing studies to translate in vitro enzymatic activity to cellular activity to drive SAR exploration.

• Oversee potential partnerships with external resources including CROs.

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point

• PhD (or relevant experience) in protein chemistry, biochemistry, enzymology or biophysics with > 5 years of drug discovery experience. Experience in pharmaceutical or biotech company is preferred.

• Excellent publication and established track record.

• Solid knowledge and experience in expression vector construction, multiple protein expression systems and various purification techniques.

• Expertise in biophysical techniques including SEC-MALS, DLS, SPR, ITC and TSA, etc.

• A background in developing enzymatic assays including enzyme kinetic and thermodynamic mechanisms or deep understanding of protein LCMS techniques is a plus.

• Experience in biostructure elucidation to understand the structure-function relationship of drug targets and to address questions on molecular targets and mechanism of actions is a plus.

• Excellent presentation, writing and coaching skills among team members.

• Experience in program leadership is preferred: high level skills leading a drug discovery program to success, leveraging know-how & accountabilities from areas outside your own area of expertise and function.

• Ability to work in new directions, building new platforms or bringing in new methods/technologies in protein science and/or biophysics.

• Communicate effectively with project teams and internal and external groups.

Who we are
At Roche, 91,700 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

The Chemical Biology Department is part of Therapeutic Modalities (TMo) within Roche Pharma Research and Early Development (pRED). We deliver leading edge science to drive the success of Roche’s early pipeline discovery research activities through strong expertise in high throughput or focused screening platforms, DNA encoded library technology, translational protein science & enzymology/biophysics, phenotypic cell-based screening and stem cell platforms, biostructure determination and computationally assisted drug discovery. Our breadth of capabilities further enable or drive innovative approaches across small, medium and large molecule therapeutic & drug delivery modalities.

Link:
Senior Principal Scientist - Chemical Biology:
http://www.roche.com/zh/careers/country/china/jobs/jobsearch/job.htm?id=E-2531803248&locale=en&title=Senior+Principal+Scientist+-+Chemical+Biology

Senior Scientist, Protein Structure and Design:
http://www.roche.com/zh/careers/country/china/jobs/jobsearch/job.htm?id=E-2516293046&locale=en&title=Senior+Scientist%2C+Protein+Structure+and+Design


[Post Date: May 04, 2017]

Title: Postdoc

Description:
POSTDOCTORAL POSITIONS AVAILABLE – CASE WESTERN RESERVE UNIVERSITY
STRUCTURAL BIOLOGY OF MEMBRANE REMODELING

Two NIH-funded postdoctoral positions are available immediately in the Ramachandran Lab at Case Western Reserve University (CWRU) to study the structural aspects of protein-mediated membrane remodeling during endocytic and mitochondrial membrane fission. These positions involve intensive collaboration with the labs of Jason Mears (cryo-EM, CWRU), Matthias Buck (NMR, CWRU), and Patrick van der Wel (ssNMR, University of Pittsburgh), and will also entail X-ray crystallography. The positions require a Ph.D. in biochemistry or biophysics with a focus on structural biology (X-ray crystallography, NMR, or cryo-EM). These positions will provide an excellent opportunity to learn and apply a wide array of structural and biophysical techniques to explore protein function on a model membrane surface. The Ramachandran laboratory also employs a host of cutting-edge spectroscopic approaches including FRET, fluorescence correlation spectroscopy (FCS) and fluorescence lifetime imaging (FLIM) to explore protein-protein and protein-membrane interactions in membrane remodeling and fission, both in vitro and in vivo. The Ramachandran lab and the facilities at CWRU are equipped with state-of-the-art instrumentation for both biophysical techniques and structural biology, as well as for protein purification, characterization and membrane reconstitution.

Requirements: Applicants must be highly motivated and must have demonstrated experience (i.e. relevant publications) in protein biochemistry and structural biology. The candidate should have a strong conceptual and experimental background in biochemistry and biophysics, as well as in the mechanistic dissection of structure-function relationships in proteins; he/she should be independent, proactive, hardworking and productive; only candidates that have first-author publications (or articles in press) will be considered. Candidates must have completed their PhD at the time of appointment. Salary will commensurate with experience and will adhere to current NIH guidelines. Interested candidates should submit their CV, reprints of selected publications, three reference letters (directly from referees), and a cover letter summarizing their experience, long-term goals, and estimated start date directly to Rajesh Ramachandran at rxr275@case.edu.

Relevant Publications. Please visit our webpage at https://physiology.case.edu/people/faculty/rajesh-ramachandran/


[Post Date: May 03, 2017]

Title: Research Scientist / Lab Manager

Description:
Research scientist/Lab manager in Protein Evolution, Thornton Lab, University of Chicago

We are seeking an experienced protein biochemist with interest in evolution, great experimental and people skills, and strong organizational ability. As a senior scientist in the lab, you will conduct independent research on the evolution of protein structure and function, help to coordinate the lab’s operations, and work closely with students, postdocs, and the PI to develop, perform, and interpret experiments and analyses.

A biochemist with expertise in structural biology would be perfect for this position. Experience in evolutionary biology is not required, but sincere interest in protein evolution is essential. Our work focuses on the molecular and biochemical mechanisms by which ancient proteins evolved their present-day functions and physical properties.

The two scientists who have previously held this position in our lab had advanced degrees and prior experience as a postdoc or lab manager. It’s a great stable position that allows you to do exciting science and play a key role in the lab’s culture.

More information and application instructions can be found at http://tiny.cc/Thorntonlabmanager.

We are a highly collegial group that draws scientists and students from a variety of disciplines – evolution, biochemistry, biophysics, molecular biology, computational biology, genetics, and more. The University of Chicago is a fantastic place to do science, especially at the interface of evolution and the molecular biosciences. Chicago is a great city rich in high and low culture; it is also a hipster heaven and, in the summer, a fun beach town. People in the lab are fun, funny, interesting, and humane.

Please don’t hesitate to contact me if you have any questions. Joe Thornton joet1@uchicago.edu


[Post Date: May 03, 2017]

Title: Postdoc

Description:
Postdoctoral Position in Structural Biology at Case Western Reserve University

An NIH-funded postdoctoral position is available for a highly motivated membrane-protein structural biologist in the laboratory of Sudha Chakrapani at the Department of Physiology and Biophysics, Case Western Reserve University. The project involves determination of protein structure and the basis for functional modulation of clinically important ion channels and transporters (Reference: Basak et. al. eLife (2017). We are using multidisciplinary state-of-the-art approaches to determine structure (X-ray crystallography and cryo-EM), protein dynamics (EPR and Fluorescence spectroscopy), and function (patching clamping in proteoliposomes and HEK cells, two electrode voltage-clamp). We are seeking candidates with a strong background in molecular biology, membrane protein expression/purification, and X-ray crystallography. Interested candidates should email Sudha Chakrapani (sxc584@case.edu) with a cover letter describing the candidate's research interests, CV, and contact details of three referees.


[Post Date: May 03, 2017]

Title: Postdocs

Description:
Opportunities exist for up to two postdoctoral scholars, available August 1, 2017, to investigate innate immunity in insects, its role in development, and in the transmission of infectious diseases. You will join an interdisciplinary group using biochemistry, biophysics, structural biology, and cell-based assays in collaboration with experts at the organismal level. Your objective will be to elucidate novel molecular mechanisms of immunity, and new connections between invertebrate and human immune responses, that can be leveraged to predict and disrupt disease transmission.
For more information, visit http://baxterlab.yale.edu.

Applicants should have a Ph.D. in chemistry, biophysics, biochemistry, molecular biology, or related discipline, record of peer-reviewed publication, and familiarity with standard laboratory techniques such as PCR/molecular biology, protein expression and purification, and analysis of proteins and nucleic acids by spectroscopy, electrophoresis, etc. The following skills are of specific interest:

Project 1: Structural analysis of complement-like proteins in the immune response of Anopheles gambiae to Plasmodium infection. Expertise in structural techniques such as x-ray crystallography, electron microscopy, small angle x-ray scattering, and/or mass-spectrometry techniques for quantitation. Experience in eukaryotic cell culture, especially baculovirus expression vector systems (BEVS).

Project 2: Functional analysis of Drosophila thioester-containing proteins in immunity and development. Expertise in cell-based assays such as flow cytometry, microscopy, RNAi knockdown and qPCR, Analysis of protein-protein interactions by proteomics/mass-spectrometry. Experience in eukaryotic cell culture, including genetic manipulation or antibody production.

Interested applicants please send (i) cover letter, (ii) curriculum vitae, and (iii) name and contact information for three references to Prof. Richard Baxter by email: richard.baxter@yale.edu.


[Post Date: May 03, 2017]

Title: Postdoc Rutgers

Description:
Postdoctoral Fellow Position

Parashar laboratory at Rutgers School of Dental Medicine is currently seeking a highly motivated, creative individual with strong interest in the structure-function studies of proteins regulating bacterial signaling.

Qualifications:
Ph.D. in Biochemistry, Molecular Biology, Structural Biology, or a related field
Experience with cloning, protein expression, and protein purification methods
A sound understanding of methods and approaches relating to macromolecular crystallography preferred
Ability to plan and carry out research projects independently
Ability to work on own initiative and take personal responsibility for delivery of work
Excellent problem solving, interpersonal, communication and presentation skills
A working knowledge of bacterial genetics and computational modeling of protein-ligand interactions preferred

Responsibilities:
Performing experiments for cloning, protein expression, and purification of proteins for biochemical and structural studies; robotic screens for crystallization; optimizing crystallization conditions; and collecting and analyzing diffraction data.
Performing model building and structure refinement.
Maintaining laboratory equipment to meet unique needs of the research activity
Assisting with preparation of grant proposals, presentations and publications
Actively seeking new collaborative projects within the department and externally

The Rutgers University Newark campus is well equipped with state-of-the-art equipment for molecular biology, protein purification, and crystallography, including crystallization robot, crystal imaging system, and X-ray generator. Please visit Parashar Laboratory website for more information. Applicants should send a cover letter, a CV, a list of publications, a summary of research experience and interests as well as the names and contact information of three references. The information should be sent via e-mail to parasharvj@gmail.com with the subject line “Postdoctoral Position Applicant”.


[Post Date: April 28, 2017]

Title: Protein Crystallographer

Description:
Protein Crystallographer

As a Senior Research Scientist, you will support our team with crystallization, data collection, processing and analysis of x-ray diffraction data and model building. You have a firm grasp of crystallographic theory to carry out or assist in the structure determination of more complex or larger quantities of structures from fragment screening campaigns, where established software fails or an individual processing through software GUIs is no longer feasible

You will be expected to assist or take over the further development and integration of our in-house LIMS and automated data processing pipeline. A firm knowledge of Linux operating systems, scripting and basic programming is indispensable, as you will likely have to interact with MySQL or Oracle servers and existing data mining routines.

As the ideal candidate, you will be highly organized and capable of handling a large number of projects including sharing and proper documentation of all your activities. You appreciate contributing to your colleague’s work, with ideas or hands-on, as well as integrating the insights of your colleagues into your own line of work. You have a problem-solving attitude and an innovative mind to help us in further developing this position as well as our company. And you enjoy communicating the results of your work to our clients all over the world, representing CRELUX as part of the WuXi AppTec family and as a global leader for structure based drug discovery solutions.

CRELUX offers structure based drug discovery service and supports its clients from Pharma, Biotech and Research Institutes with expertise and an external work force. We are operating as a part of WuXi AppTec - one of the leading Contract Research Organizations worldwide.

WuXi AppTec operates from over 20 research sites and employs over 14.000 people in China, the US and Europe. Within WuXi AppTec’s Research Service Division (RSD) we act as the global center of excellence in hit finding, validation and confirmation projects. As such CRELUX’s biophysical assay, screening and crystallography departments are forming a pivot service platform for all integrated drug discovery programs WuXi AppTec executes for clients.

Are you interested in becoming a CRELUX employee?

We offer competitive salaries and a work environment that is science-based, collaborative and inspiring. The success of our company is based on a “clients first” attitude and cooperative efforts - which make excellent organizational and communication skills essential. We benefit from the diversity of our workforce and are proud to be an equal opportunity employer.

For additional information visit our website, www.crelux.com. Please send your complete application for this position as a single .pdf file to:

CRELUX GmbH
Am Klopferspitz 19a
82152 Martinsried

Dr. Michael Schaeffer
michael_schaeffer@wuxiapptec.com
+49 89 700760-170


[Post Date: April 28, 2017]

Title: Postdoc Monash University

Description:
Post-doctoral research fellows: Lipid -mediated immunity

MONASH UNIVERSITY
Infection and Immunity Program, Biomedicine Discovery Institute
Faculty of Medicine, Nursing and Health Sciences

Prof. Jamie Rossjohn FAA FLSW, ARC Australian Laureate Fellow & Head, Infection and Immunity Program, Monash Biomedicine Discovery Institute, seeks postdoctoral researchers to join his research group to work in the area of structural biology centered on T-cell mediated immunity to lipid antigens, at Monash University, Clayton campus.

The Rossjohn laboratory has provided profound insight into the molecular bases underpinning lipid-mediated immunity (e.g. Nature 2007, Immunity 2009, 2011, Nature Immunol. 2012, 2015 & 2016), and seeks to build upon these initial findings in the context of protective, tumour and aberrant immunity. The laboratory is funded by grants from the NHMRC and ARC.

For more details on the research themes, fellowships awarded and publication outputs see, http://research.med.monash.edu.au/rossjohn/

The applicants should hold a PhD, have a proven track record in the field of protein chemistry, and be sufficiently self-motivated to pioneer new areas of Immunity.

Candidates with a promising track record in the relevant areas and a proven publication record in international journals are encouraged to apply.

Appointment will be made at a level appropriate to the successful applicant’s qualifications, experience and in accordance with classification standards for each level.
Salary range: Level A $81,486 - $87,471 or
Level B $92,074 - $109,339,
Duration: ?Position - up to 3 years.??
Location:?Clayton Campus

Closing Date: 1st June 2017

Please direct all enquires to Jennifer Huynh (Jennifer.huynh@monash.edu)


[Post Date: April 28, 2017]
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