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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Postdoc UTMB
Website: https://microbiology.utmb.edu/faculty/matthieu-gagnon

Description:
Postdoctoral position at The University of Texas Medical Branch (UTMB)

We have an immediate opening for a talented, highly motivated postdoctoral scholar in my laboratory at The University of Texas Medical Branch (UTMB) located in Galveston, TX (USA) to study the structure and function of ribosome functional complexes (https://microbiology.utmb.edu/faculty/matthieu-gagnon). The successful candidate will be involved in the characterization of prokaryotic and eukaryotic ribosomes, translation factors and other RNA/protein complexes. The research in our laboratory aims to elucidate the mechanisms of protein synthesis, antibiotic resistance and regulation of translation at a structural level using a combination of macromolecular X-ray crystallography, single-particle cryo-electron microscopy (cryo-EM) and biochemical techniques.

The desired qualifications are:
• Ph.D. in biochemistry, chemistry, biophysics, or a related field;
• Practical skills in molecular biology, protein expression/purification, and various biochemical techniques;
• Experience in structural biology (cryo-EM and/or X-ray crystallography);
• Strong interest and motivation to elucidate the molecular mechanisms of protein synthesis and antibiotic resistance through structure determination.

The successful candidate will have an excellent track record and is expected to drive forward the projects, act independently or semi-independently, compile, analyze and write up data for publication, assist with the training of graduate students and work co-operatively with others.

Structural biology facilities at UTMB are outstanding (https://www.utmb.edu/core). Our cryo-electron microscopy (cryo-EM) core facility recently acquired the FEI Titan Krios high-voltage (300 kV) electron microscope equipped with two direct detector cameras, Falcon 3 (ThermoFisher) and K3 (Gatan), ideal setup for high-resolution structure visualization. Other cryo-EM resources include a JEOL 2200FS cryo-EM microscope equipped with a DE20 direct electron detector for high-resolution imaging work and a liquid nitrogen autofilling system allowing week-long experiments, a cryo-microscope JEOL 2100, an FEI vitrobot cryo-plunger, a Leica EM-GP2 cryo-plunger, a Gatan Solarus plasma cleaner. X-ray crystallography resources include two X-ray area detector systems, a Phoenix crystallization robot, a Minstrel crystal imaging robot, the Alchemist and epMotion liquid handling robots. Other state-of-the-art facilities include NMR, next-generation sequencing, molecular genomics, high-throughput screening, solution biophysics, optical microscopy and computational biology.

Ample opportunities exist at UTMB for interactions with centers of scientific excellence in structural biology and molecular biophysics, biodefense, molecular medicine, cancer biology, infectious diseases, environmental health, aging, and translational sciences (https://www.utmb.edu/centers). Moreover, UTMB boasts a renowned, vibrant and highly active community of infectious disease researchers and clinicians, providing ample opportunities for broader collaborations and development.

Review of applications will begin immediately and will continue until the position is filled. Interested applicants should send their CV along with a cover letter briefly describing their research accomplishments, current research interests and contact information for three references in a single PDF directly to Dr. Matthieu Gagnon at magagnon@utmb.edu.


[Post Date: March 20, 2019]

Title: Postdoc UC Savis
Website: https://recruit.ucdavis.edu/JPF02735

Description:
An opportunity is available for a postdoctoral fellow to work with Jawdat Al-Bassam (http://microtubule.mcb.ucdavis.edu) at the Molecular Cellular Biology Department at the University of California at Davis. The Al-Bassam laboratory is focused on structural studies of assemblies regulating the biogenesis and polymerization of tubulin dimers and their impact on the polymerization of microtubules. The projects aim to characterize tubulin regulation by multi-subunit complexes using biochemical reconstitution, cryo-electron microscopy (cryo-EM) and x-ray crystallography. We have a particular interest in determining structures of multi-subunit complexes using well-developed tools in the laboratory, and then we aim to test functional mechanisms using in vitro reconstitution with dynamic microtubules. We are looking for an enthusiastic individual who thrives in a collaborative and supportive atmosphere. You should have a PhD in chemistry, biochemistry or biophysics and a desire to understand structures of multi-subunit macromolecular assemblies in relation to their functional mechanisms. Expertise required include molecular cloning, recombinant protein production using bacteria, insect and mammalian cells. The position would suit someone with a strong background in X-ray crystallography who also wants to learn cryo-EM, or someone who already has experience in cryo-EM and single particle image analysis. Please see our recent papers: https://elifesciences.org/articles/38922#, https://elifesciences.org/articles/08811.

The Al-Bassam laboratory has extensive tools and setups for protein production, biochemical characterization, x-ray crystallography in addition to computational resources. The laboratory has full access to a well-supported UC-Davis BIOEM facility, which includes cryo-EM sample preparation, a semi-automated side-entry JEOL 2100F microscope, and a new 200 KV Glacios microscope equipped with an autoloader and a K3 detector. UC-Davis is a member of the Bay Area Cryo-EM consortium with monthly access to Titan Krios microscopes for high resolution data collection.

Please send any informal inquiries to jawdat@ucdavis.edu. Please include a cover letter, CV, statement of research accomplishments, and two to three reference letters.

To apply and access full details of the position please visit: http://microtubule.mcb.ucdavis.edu or https://recruit.ucdavis.edu/JPF02735


[Post Date: March 18, 2019]

Title: Postdoc UT Health Science Center

Description:
The laboratory of Dr. Yogesh Gupta at University of Texas Health Science Center in San Antonio (UT Health San Antonio™) is seeking a highly motivated and enthusiastic Postdoctoral Fellow with strong interest in structural and mechanistic studies on protein-nucleic acid complexes implicated in post-transcriptional gene regulation and chromatin biology. We combine various structural biology tools (X-ray, NMR, cryo-EM, AUC, SAXS) with in silico, and cell-based methods to address basic mechanistic questions, and exploit this knowledge for drug discovery. Our well equipped lab is physically located within the Greehey Children’s Cancer Research Institute (Greehey CCRI) at UT Health San Antonio. In addition, we have full access to an extensive array of institutional core facilities (Biochemistry core, CIDD, Research core labs), and regular access to synchrotron beamlines.

Applicants with demonstrated experience in protein biochemistry and structural biology, and a keen interest in studying large macro-molecular assemblies are preferred. Candidates are expected to possess strong organizational, interpersonal skills, and ability to work as part of a team. Candidate should hold (or soon expect to hold) a PhD or equivalent degree in a related discipline. Prior experience in X-ray crystallography, biophysical methods (SPR, AUC, ITC etc.), and enzyme kinetics is desirable.

Salary is competitive. San Antonio offers affordable cost of living and there is no state income tax in Texas.

Please visit the websites below to learn more about our work and future directions –
http://ccri.uthscsa.edu/YGupta.html

If interested in applying, please send a short description of your research accomplishments, and current CV with a list of three (3) references to Dr. Yogesh Gupta (email: guptay@uthscsa.edu).

The Greehey Children’s Cancer Research Institute is a unique specialized cancer research center focusing on basic and translational research in childhood cancer and occupies a state-of-the-art 100,000 sq. foot research facility on the university’s Greehey Academic and Research Campus.

San Antonio is the nation’s seventh largest city and is located at the edge of the beautiful Texas Hill County. San Antonio offers a rich, multi-cultural community, affordable cost of living, excellent weather and a thriving biomedical industry.

All Postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Opportunity/Affirmative Action Employer including protected veterans and persons with disabilities.


[Post Date: March 18, 2019]

Title: Postdoc Masaryk University
Website: https://loschmidt.chemi.muni.cz/peg/

Description:
We are seeking a highly motivated scientist for an EU-funded postdoctoral position in protein structural biology for an experimental team at Loschmidt Laboratories, Masaryk University, Brno, Czech Republic (https://loschmidt.chemi.muni.cz/peg/). We conduct basic research in enzymology and fight acute stroke, cancer and Alzheimer’s disease.

JOB DESCRIPTION:
Perform protein expression, purification and biophysical characterization.
Design and perform protein crystallization experiments.
Collect X-ray diffraction data and determine protein-ligand complex structures.
Adapt emerging structural techniques: nanocrystallography and cryo-EM.
Work in a friendly, inspiring and highly collaborative environment.
Opportunities for further training, personal growth and benefits package.

CANDIDATE PROFILE:
PhD in structural biology, molecular biology, biochemistry or biophysics.
Experience with protein expression and purification.
Previous experience with protein structural techniques.
Experience with biophysical and biochemical protein characterization.
Willingness to learn new techniques: nanocrystallography and cryo-EM.
Ability to develop new concepts; goal-oriented and problem-solving skills.
Good proficiency in English.

APPLICATIONS:
Curriculum Vitae and motivation letter.
Two letters of recommendation.
Send your application to Jitka Sedlackova at jitkasedlackova@mail.muni.cz

SELECTED PAPERS:
J. Am. Chem. Soc. 140: 17999, 2018 ACS Catalysis 8: 9420, 2018 J. Am. Chem. Soc. 137: 4988, 2015 ACS Catalysis 6: 7597, 2016
Chem. Rev. 113: 5871, 2013 Curr. Opin. Chem. Biol. 19: 8, 2014
Angewandte Chemie 52: 1959, 2013 Nature Chem. Biol. 10: 428, 2014



[Post Date: March 14, 2019]

Title: Postdoc Positions Fudan University of Shanghai

Description:
The Multiscale Research Institute for Complex Systems (MRICS) at Fudan University is located at the Zhangjiang Campus of Fudan University and is supported by the Shanghai High-peak Program. MRICS is strongly committed to the development of novel and effective multi-scale imaging technology that spans microscopic molecular structures all the way to macroscopic medical imaging, with the aim to provide unprecedented spatial and temporal insights into the structures and functions of living beings at all levels (molecules, cells, tissues, organs and even whole organisms). MRICS is equipped with a state-of-the-art cryo-EM facility that includes FEI Titan Krios equipped with Volta phase plate, Glacios, Talos and Aquilos. It is also located next to Shanghai Synchrotron Radiation Facility for X-ray crystallography.
Our team includes Nobel laureate and international leading interdisciplinary experts.
We are now open to recruit a number of postdoctoral fellows with trainings in various scientific fields. These include but are not limited to:
1.Structural biology (X-ray crystallography and cryo-electron microscopy
including single-particle and tomography);
2.Biochemistry or protein chemistry (no structural biology background is
required);
3.Genetics, epigenetics or cell biology (experience in cell or tissue
imaging is preferred);
4.Computational biology (the development of large-scale molecular dynamics
simulation algorithms, algorithmic development related to electron microscopy
imaging techniques, and the application of artificial intelligence in biology.
We particularly welcome applicants with Ph.D. degree in theoretical physics,
computational physics or condensed matter physics);
5.Development of experimental animal disease models (experience in experimental animal research is preferred).

Other criteria:
1) Recent Ph.D. graduates
(within three years of graduation) from a well-known university or research institute anywhere in the world;
2) Fluent in English;
3) Published high-level research articles in the past three years.

Compensation:
1) We offer internationally competitive annual salary, the level will be determined according to the applicant's experience and qualification;
2) We will assist in applying for low-rent housing in Shanghai and provide certain housing subsidies;
3) We have ample opportunities to collaborate with renown laboratories worldwide;
4) We provide support for applying for funding opportunities whenever applicable.

For interested applicants, please submit postdoctoral application packages including resumes, concise research interest statements, representative publications, phone numbers and email addresses of three academic referees to: Miss Lingyue Guo ( Email: lyguo@fudan.edu.cn).

We look forward to your joining of our first-class team!


[Post Date: March 12, 2019]

Title: R&D Associate MedImmune
Website: https://careers.astrazeneca.com/

Description:
MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.

We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities
Major responsibilities include planning and executing experiments related to developing protein engineering platforms for therapeutic antibody generation and optimization. She/he will work with scientists to create research plans, execute experiments, analyze and interpret data and present results to the group and the department. She/he is expected to have a strong work ethic, excellent organizational skills and keep good records. Strong team-based communication and presentation skills will be required.

Essential Requirements
• The ideal candidate should have strong hands-on experience in Molecular Biology or Biochemistry, particularly PCR and molecular cloning techniques.
• Protein expression, purification and characterization experience is also required.
• Experience in cell culture, FACS and antibody engineering (phage/yeast display-based selections) is not required but is also highly desirable.

Education and Experience
• Research Associate II - Bachelor’s Degree in Molecular Biology or other related fields with two to five years of relevant experience in industry (preferred) or academia, or Master’s Degree with zero to two years of relevant experience in industry (preferred) or academia

• Associate Scientist I – Bachelor’s Degree in Molecular Biology or other related fields with five to eight years of relevant experience in industry (preferred) or academia, or Master’s Degree with two to five years of relevant experience in industry (preferred) or academia
Knowledge
• Hands-on experience with advanced PCR and molecular cloning techniques, particularly where troubleshooting was required to drive a project forward
• Familiarity with cell culture, recombinant protein production and purification. Biochemical characterization such as affinity determination and immunoassays (ELISA).
• Experience with antibody engineering and FACS is highly desirable.
• The ability to learn and embrace new technologies quickly, work independently and communicate well with the team.


[Post Date: March 11, 2019]

Title: Postdoc SGC-UNICAMP, Brazil
Website: https://www.nature.com/naturecareers/job?id=679937

Description:
We are looking to recruit a highly motivated and ambitious individual to take a leading role in developing new inhibitors for putative drug targets in Neglected and Emerging Infectious Diseases.

The Structural Genomics Consortium at UNICAMP (SGC-UNICAMP, Brazil) combines protein structure, biochemistry and medicinal chemistry to develop small molecule inhibitors that can be used to validate potential drug targets.

The successful candidate should have a strong background and interest in biochemistry and structural biology. We are looking for a creative and ambitious person with good communication skills and keen to work on challenging projects.

For further details and to apply for this position, please follow the link.

Our lab is situated in Campinas, São Paulo Brazil and is one of the laboratories of the Structural Genomics Consortium (https://www.thesgc.org/).


[Post Date: March 11, 2019]

Title: Postdoc The Wistar Institute

Description:
A Post Doctoral Fellow position is immediately available in the laboratory of Dr. Emmanuel Skordalakes at The Wistar Institute. The laboratory studies protein, nucleic acid assemblies that participate in the replication and maintenance of telomeres and have been implicated in a host of diseases including cancer. Areas of interest include the telomere replication and maintenance nucleoprotein complexes telomerase, CST and shelterin. We use a multidisciplinary approach involving biochemical, biophysical and cell based assays to address mechanistic questions related to the function of the above protein-nucleic acid assemblies. Our goal is to understand how telomeres are replicated, how shelterin and CST regulate this process and how dysfunction of these complexes leads to human disease. Information obtained from these studies will be used to identify activity modulators of telomerase and associated complexes as potential therapeutics for cancer and age-related diseases.

We are looking for highly motivated candidates that have recently acquired or will be acquiring a Ph.D. in biochemistry, structural biology or a related field and have a record of peer reviewed publications.

Additional information regarding our research program can be found at the laboratory's web sites

http://webdev.chem.upenn.edu/chem/research/faculty.php?id=52

http://www.wistar.org/lab/emmanuel-skordalakes-phd

Interested applicants should e-mail their CV along with a cover letter briefly describing their research accomplishments and current research interests to Emmanuel Skordalakes, Ph.D., Associate Professor (skorda@wistar.org).

The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. Research discoveries conducted at Wistar have led to the development of vaccines; the identification of genes associated with cancers; and the development of many other significant research technologies and tools.

We offer an excellent benefits package.


[Post Date: March 05, 2019]

Title: Postdoc University of Chicago
Website: https://voices.uchicago.edu/themendozagroup/opportunities/

Description:
The Mendoza group at the University of Chicago is looking to recruit highly motivated, productive, and challenge seeking individuals.

The Mendoza group applies protein engineering strategies to solve challenging complex structures (Mendoza et al., Nature, 2019; Mendoza et al., Immunity, 2019) using X-ray crystallography. This position will also be expected to establish cryo electron microscopy in the laboratory.

The successful candidate should have a strong background and interest in biochemistry and structural biology. Experience with the expression and purification of membrane proteins a plus.

Please send a letter of interest, CV, and reference information to Juan Mendoza at juan.mendoza@uchicago.edu.


[Post Date: March 05, 2019]

Title: Postdoc SGC, Toronto, Canada

Description:
The Structural Genomics Consortium (SGC), within the Faculty of Medicine at the
University of Toronto has an exciting opportunity for a Postdoctoral Fellow in the SGCs
Huntington’s Disease Research Group.

The successful candidate will have research interests and experience in protein structural
biology linked to health and disease. The candidate will work within a multidisciplinary
environment to investigate proteins and protein complexes associated with Huntington’s
disease. Candidates will make extensive use of protein biochemistry, biophysical analysis
of protein samples, X-ray crystallography and other structural characterization methods.

Qualifications required include:
• Ph.D. in biochemistry, X-ray crystallography, structural biology or a closely related
field;
• Knowledge of molecular biology, heterologous protein expression systems, and
protein biochemistry and characterization is essential;
• Experience in a high throughput structural biology setting is an advantage;
• Documented strong organizational skills;
• A track record of successfully working within a small team of scientists to achieve
aggressive project milestones;
• A track record of collaboration with multiple partners in a multi-disciplinary
environment;

The SGC is a public/private partnership with a mandate to carry out protein-based research
relevant to human health and drug discovery. The SGC offers a competitive salary and
benefits package, including an array of special programs offered to University of Toronto
staff.

Interested applicants should forward electronic versions (Microsoft Word or PDF files)
of: 1) a cover letter; 2) a Curriculum Vitae; 3) a brief overview of research interests; 4)
names and contact information of at least 3 referees who would be willing to provide
letters of recommendation. Please send applications to SGC Toronto Business Manager
greg.brothers@utoronto.ca before Friday 29th March 2019.

The University of Toronto is strongly committed to diversity within its community and
especially welcomes applications from visible minority group members, women,
Aboriginal persons, persons with disabilities, members of sexual minority groups, and
others who may contribute to the further diversification of ideas. All qualified candidates
are encouraged to apply; however, Canadians and permanent residents will be given
priority.


[Post Date: March 05, 2019]

Title: Postdoc UCL/Birbeck, London, United Kingdom
Website: https://goo.gl/UBwvWK

Description:
Institute of Structural and Molecular Biology
University College London and Birkbeck College
Postdoctoral Researcher in Structural Biology

A Wellcome Trust funded 3-year postdoc position is available in our lab to work on the molecular mechanisms of chromatin modification and transcription using biochemical, biophysical and structural biology methods.

Our lab is located in Birkbeck College as part of the joint UCL/Birkbeck Institute of Structural and Molecular Biology (ISMB). The ISMB is a vibrant and international research community in the centre of London, and has in-house access to state-of-the-art structural biology and biophysics facilities.

Apply here: https://goo.gl/UBwvWK
Informal enquires can be sent to alan.cheung@ucl.ac.uk

Our lab website: https://cheunglab.net
Our local community: http://people.cryst.bbk.ac.uk/~ubcg16z/empage.html
Our institute: http://www.ismb.lon.ac.uk/


[Post Date: March 05, 2019]

Title: Postdoc AFMB, Marseille, France
Website: http://www.afmb.univ-mrs.fr/post-doctoral-position,587

Description:
A post-doctoral position funded by ANR project GAGOsynth is available for a structural biologist in the team “Structural Glycobiology and Neurobiology” at the AFMB laboratory, Marseille, France. We are seeking for an enthusiastic, highly motivated and creative individual with solid knowledge and expertise in structural biology and biochemistry to investigate the structure-function relationships of enzyme complexes involved in heparan sulfate (HS) biosynthesis in collaboration with the groups of Hugues Lortat-Jacob and Guy Schoehn at IBS (Grenoble, France). In particular, we aim at deciphering how the concerted action of HS biosynthetic enzymes can encode defined oligosaccharide motifs along the polymer to modulate activity of various protein ligands.

Candidates must have a recent Ph.D. (or being in the process of completing one) in a relevant field with a demonstrated record of productive research. Experience in protein expression, particularly in eukaryotic cells, in biochemistry, and in X-ray crystallography or single particle cryo-EM is highly desirable.

Applicants are invited to submit i) a cover letter describing research interests, ii) a CV and iii) the names and contact details of three references to Yves Bourne (yves.bourne@afmb.univ-mrs.fr).

Application deadline: April 30, 2019


[Post Date: March 05, 2019]

Title: Postdoc Leicester, United Kingdom
Website: https://jobs.le.ac.uk/vacancies/vacancy-details.aspx?VacancyID=162&Display=1

Description:
We are looking to recruit highly motivated and ambitious individual to take a leading role in investigating higher–order signaling complexes in gene and chromatin regulation.
The Panne group uses X-ray crystallography and cryo electron microscopy to study higher–order signaling complexes that are important in inflammatory/cancer signaling and gene/chromatin regulation and assembly (e.g. see Nature 2018, 562(7728):538-544).

The successful candidate should have a strong background and interest in biochemistry and structural biology. We are looking for a creative and ambitious person with good communication skills and keen to work on a challenging project.

Experience in biochemistry of protein complexes, insect cell expression systems, X-ray crystallography or cryo-electron microscopy would be particularly beneficial. The group is part of the Leicester Institute of Structural and Chemical Biology (LISCB one of five flagship research institutes recently established by the University of Leicester, UK. We have excellent access to state-of-the-art structural biology technologies including a Krios cryo-EM microscope equipped with Falcon 3EC and GATAN K2 (planned upgrade to K3 in early 2019) detector as well as the Diamond and ESRF Synchrotrons.

Please apply online at the link.


[Post Date: March 01, 2019]

Title: Postdoc IMB FLorida State University
Email: hong.li@fsu.edu

Description:
NIH-funded postdoctoral positions are immediately available in Dr. Hong Li’s laboratory at the Institute of Molecular Biophysics, Florida State University, to study nucleic acids-protein interactions by electron cryomicroscoscopy (cryoEM), X-ray crystallography and other complementary methods. The ideal candidates should have a strong background in or are willing to learn cryo-EM or X-ray crystallography.

Dr. Hong Li’s laboratory is located in the Florida State University, Tallahassee, Florida. The Institute has recently become the NIH Center for Electron Microscopy of the southeast region, housing an FEI Titan Krios microscope equipped with a Phase Plate, a K3 Summit or a DE64 direct electron camera and High Performance Computing capabilities. The Institute of Molecular Biophysics has a major focus on structural biology hosting multiple research groups utilizing cryo-EM, X-ray diffraction, spectroscopy and theoretical computations, which allows anyone within the Institute seamlessly integrate these structural biology methods.

Tallahassee is the capital for the state of Florida and is about 1.5 hour drive to the beautiful beaches along the Gulf of Mexico. The capital city also has variety of music, athletic, theater, and film activities offered by the world-class teams and the school of music and arts.

The standard NIH annual salary for the postdoctoral fellow starts at $47,659 with full health and retirement benefits that can be increased annually upon satisfactory evaluation. Interested candidates should send a recent CV, two names of references to

Dr. Hong Li
Director, Molecular Biophysics Graduate Program Institute of Molecular Biophysics
Florida State University Tallahassee, FL 32306


[Post Date: March 01, 2019]

Title: Postdoc Oak Ridge National Laboratory
Website: http://tinyurl.com/yxuzzk92

Description:
Postdoctoral Research Associate at the Center for Structural Molecular Biology, Oak Ridge National Laboratory

The Center for Structural Molecular Biology (CSMB) has a postdoctoral fellow position available to work in the area of structural biology/experimental biophysics. In this position, you will be expected to contribute to the development of methods for investigating the structure of biomacromolecular complexes and assemblies using neutron scattering in combination with other experimental approaches. Desirable skills include expertise in biological structure determination using scattering and/or diffraction techniques, protein expression and purification, and molecular simulations. Prior experience in characterizing membrane protein complexes is preferred. You will be involved in structural measurements on a range of macromolecular targets and data analysis using state-of-the-art techniques and facilities available at the High Flux Isotope Reactor (HFIR), the United States' highest flux reactor-based neutron source, and the Spallation Neutron Source (SNS), the world's most intense pulsed accelerator-based neutron source (http://neutrons.ornl.gov). You will also have access to a suite of biophysical characterization tools, as well as external synchrotron facilities. The CSMB is a premier research center focused on the characterization of biological systems with relevance to environmental, biotechnological and biomedical systems. It supports the biological small-angle neutron scattering (Bio-SANS) instrument at HFIR and the bio-deuteration laboratory, dedicated to the production of labeled biomolecules, at the SNS. It has an outstanding group of scientists and technical staff focused on basic and applied research, and strong ties to the Oak Ridge Leadership Computing Facility and Center for Nanophase Materials Science.


[Post Date: February 26, 2019]

Title: Postdoc EMBL Grenoble
Website: https://www.embl.fr/jobs/searchjobs/index.php?ref=GR00133

Description:
We are looking for a highly motivated and ambitious individual to progress our understanding of the mechanism of transcription by influenza virus RNA-dependent RNA polymerase. The work is in the frame of the ANR-funded FluTranscript project that brings together the complementary expertise of the groups of Stephen Cusack (EMBL Grenoble, project coordinator) and Nadia Naffakh (Institut Pasteur) in structural biology and molecular virology, respectively. The project follows on from a recent joint publication (Structural basis of an essential interaction between influenza polymerase and Pol II CTD. Lukarska et al, Nature 2017) and aims to reconstitute and determine the structure of functional transcription complexes. A secondary goal is to use the acquired structural information to develop new approaches to anti-influenza drug development.

The Cusack group uses X-ray crystallography and cryo electron-microscopy to study the structural biology of protein-RNA complexes involved in RNA virus replication, innate immunity and cellular RNA metabolism. Group website:
https://www.embl.fr/research/unit/cusack/index.html

The successful candidate should have a PhD in Molecular Biology or related field and a strong background and interest in biochemistry and structural biology.
We are looking for a creative and ambitious person with good communication skills and keen to work on a challenging project.

Experience in insect cell expression systems, reconstitution of protein-RNA complexes, X-ray crystallography or cryo-electron microscopy would be particularly beneficial.

EMBL is one of the world’s leading research organizations in the life sciences. The Headquarters Laboratory is located in Heidelberg, with additional sites in Barcelona, Grenoble, Hamburg, Hinxton, and Rome.

EMBL Grenoble has excellent access to state-of-the-art structural biology technologies with the in house EM facility being equipped with a
T12 microscope and 200kV Glacios/Falcon III . Additionally, we have access to the Titan Krios at the adjacent ESRF as well as those in EMBL Heidelberg. Other facilities on the Grenoble Campus include the ESRF synchrotron X-ray beamlines, neutron scattering at the ILL, high-field NMR at the IBS as well as high-throughput crystallization platform, mammalian and insect cell facilities, biophysical platform and confocal microscopy.


[Post Date: February 26, 2019]

Title: Beamline Scientist AMX beamline, NSLS-II
Website: https://jobs.bnl.gov/job/upton/beamline-scientist-highly-automated-macromolecular-crystallography-amx/3437/10947993

Description:
A position of beamline scientist for the highly Automated Macromolecular Crystallography beamline (AMX) at the National Synchrotron Light Source II is currently open.

The National Synchrotron Light Source-II (NSLS-II) at Brookhaven National Laboratory seeks a scientist to join the Structural Biology program that operates two state-of-the-art macromo¬lecular crystallography (MX) beamlines, one life-sciences scattering beamline, and a cryo-EM facility. The successful candidate will be keen to make best scientific use of the MX beamlines with their micro-focus beams and high degree of automation. Our early experience with these cutting-edge MX beamlines shows that they have ability to produce usable data rapidly from crystals that gave poor diffraction elsewhere.

The principal work in the next years will be to support all aspects of the beamline operations and to continue developing these instruments to expand opportunities for structural biology research.

Position Description

The new scientist who joins this multi-national group operating cutting-edge instruments will bring innovation and teamwork to further the quality of X-ray crystallography beamlines. The successful candidate will be encouraged to develop opportunities for scientific collaborations that exploit the unique qualities of our beamlines. We would emphasize extending the mission and technical scope of the beamline, especially by increasing automated data processing in our high-performance computing environment and enhancing specimen-handling automation. Responsibilities will also include interacting with the scientific user community to augment their scientific productivity with complementary NSLS-II life-science user programs and our cryo-EM facility.

Our group operates 2 state of the art MX beamlines, AMX (high throughout and automation) FMX (frontier experiments including serial crystallography) and LIX the life science scattering beamline.

AMX is a microfocus beamline with a beam size of 7x5 um2 and a flux of 4.5 1012 ph.s-1.

AMX is a tunable beamline with a 5-18 keV range, well suited for high resolution data collection from large assemblies and native phasing from challenging samples.

AMX is equipped with a state-of-the-art robotics system, a high capacity sample Dewar holding up to 384 samples and an Eiger 9M detector.

Further details and how to apply can be found at the link.


[Post Date: February 25, 2019]

Title: Postdoc UC Santa Cruz
Website: https://rubinlab.sites.ucsc.edu/

Description:
A funded postdoctoral position in structural biology is available in the laboratory of Seth Rubin at University of California, Santa Cruz. Our group studies molecular mechanisms controlling cell division and cell-cycle dependent transcription. Potential projects will apply x-ray crystallography, cryo-EM, and NMR toward determining protein structure and function and toward drug discovery. Write srubin@ucsc.edu.

[Post Date: February 25, 2019]
TECHNICAL SUPPORT
Tel: 949-425-1321
Fax: 949-425-1611
Email: tech@hrmail.com
LOCATION
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