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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Postdoc Institut Pasteur
Contact: Marco Bellinzoni
Email: marco.bellinzoni@PASTEUR.FR

Description:
A 2-year post-doc position is currently available at the Structural Microbiology Unit, located at the Institut Pasteur in Paris.

Our team has been working on the molecular mechanisms underlying the metabolic plasticity of Actinobacteria, with a special emphasis on the signaling pathways involved (for an overview of the topic and our recent work, please see Wagner et al., Sci. Signal., 2019; Bellinzoni et al., Genes Immun., 2019). The postdoctoral fellow will join an active and multidisciplinary environment, working on Corynebacterium glutamicum enzymes and protein complexes involved in central metabolism, and applying an integrative structural biology approach in which cryo-EM plays a key role. The project is part of a French-German initiative funded by the respective national research agencies (ANR and DFG), and will be performed in collaboration with the groups led by Profs. Michael Bott (Forschungszentrum Jülich) and Bernhard Eikmanns (University of Ulm).

The Structural Microbiology Unit is fully equipped for microbiology and protein biochemistry work, and has a well-established network of collaborations. In addition, the institute’s campus provides a vibrant scientific life as well as access to excellent core facilities. A full range of state-of-the-art equipment for structural biology and biophysics is available, including a Titan Krios and two Glacios microscopes currently undergoing installation. The unit has also regular access to synchrotron beamlines for X-ray crystallography and SAXS.

The position is open from October 2019, although the starting date may be arranged. The ideal candidate is an enthusiastic PhD with a good publication record and a solid background in protein biochemistry and biophysics. Good team spirit and presentation skills in English are essential; experience in dealing with large macromolecular complexes, protein-protein interaction studies and/or cryo-EM would be an asset. Interested candidates should provide a full CV with a summary of previous research experience, a brief statement of interest on the position and contacts of a couple of referees to marco (dot) bellinzoni (at) pasteur (dot) fr. Please send applications or informal enquiries no later than June 5.


[Post Date: May 20, 2019]

Title: Principal Beamline Scientist
Website: https://vacancies.diamond.ac.uk/vacancy/principal-beamline-scientist-vmxi-378979.html

Description:
We currently have an opportunity to lead beamline VMXi at Diamond Light Source. The beamline is in the optimisation stage of its user programme for in situ experiments and early commissioning developments of its serial crystallography capabilities, presenting a unique opportunity for the post holder to develop methodologies and a complementary user programme for room temperature crystallography with these sample delivery methods.


[Post Date: May 20, 2019]

Title: Postdoc University of Dundee
Website: https://ig5.i-grasp.com/fe/tpl_uod01.asp?newms=jj&id=103176&newlang=1

Description:
Professor Alessio Ciulli’s laboratory is seeking a postdoctoral researcher to undertake research in collaboration with one of the leading pharmaceutical companies supporting the Division of Signal Transduction Therapy (DSTT). The DSTT facilitates collaborations between some of the world’s major pharmaceutical companies (Boehringer Ingelheim, GlaxoSmithKline, and Merck-Serono) and leading Dundee-based researchers with a proven track record of achievement in understanding and exploiting the fundamental molecular causes of human disease in the fields of cancer, immune-regulation, neurodegeneration and hypertension resulting from disruptions in protein ubiquitylation, phosphorylation and other signalling networks.

The successful applicant will be based within the Ciulli lab in Dundee (http://www.lifesci.dundee.ac.uk/groups/alessio-ciulli). The laboratory is pioneering novel chemical structural biology approaches to target E3 ubiquitin ligases with small molecules. The applicant will employ state of the art structural biology, cell biology and biophysical approaches to conduct molecular and structural studies on disease-relevant human E3 ubiquitin ligases. The Ciulli lab has close collaborations and access to facilities available within both the MRC Protein Phosphorylation Unit (http://www.ppu.mrc.ac.uk/) and more widely within the School of Life Sciences. This set-up will ensure the successful candidate will have access to whatever technologies required to conduct the projects that they are working on, including molecular, biochemical, mass spec proteomics, pharmacological and genetic methodologies including CRISPR/CAS9 knock-out and knock-in technologies. There will be regular opportunity for interaction and to discuss data within the group and with the collaborating pharma company.

Candidate requirements:

? PhD with outstanding academic track record and at least one first authored publication in an internationally recognised peer-reviewed journal.
? Strong background in Biochemistry, Molecular Cell Biology, or Structural Biology is required.
? Strong interest in signal transduction research and how disruptions of these pathways are linked to human disease is expected.
? Experience with recombinant protein expression and purification, molecular cloning, and protein X-ray crystallography (or cryo-EM) is required.
? Experience with mammalian cells tissue culture, and protein-protein interaction studies inside cells e.g. pull-down, proteomics, would be highly advantageous.
? Experience with biophysical methods to study in vitro protein-protein and protein-peptide interactions is desirable.
? Capable of working in a team, but able to plan and work independently.
? Excellent communication skills and knowledge of the English language are essential.
? The candidate should have ambitions to become a successful independent researcher either in academia or the pharmaceutical/biotechnology industry.

The fund for this project is available till 30th June 2020 in the first instance with a chance to renew.

Closing Date 31 May 2019


[Post Date: May 20, 2019]

Title: Research Positions at CEI
Website: https://port.engageats.co.uk/

Description:
We are delighted to announce the opening of 13 research positions in our new Centre for Enzyme Innovation (CEI). The CEI has a focus around the development of biological solutions for plastic recycling and upcycling, but also around the discovery, characterisation and engineering of enzymes for biomass conversion.

We are currently expanding the CEI with 4 Senior Research Fellows and an Innovation Fellow, 6 Senior Research Associates, 2 Specialist Research Technicians and multiple PhD studentships.

Three pdf candidate packs provide an overview of the positions at the different levels and these can be found on the CEI website:
https://www.port.ac.uk/research/research-centres-and-groups/centre-for-enzyme-innovation

Full job descriptions and person specifications are available on our recruitment website (https://port.engageats.co.uk/). See ‘External vacancies’. Please note that some of the positions have a short closing date. Thank you for your interest.


[Post Date: May 16, 2019]

Title: Research Associate University of Cambridge
Website: http://www.jobs.cam.ac.uk/job/21519/

Description:
The University of Cambridge wishes to appoint a Postdoctoral scientist to join the research group of Dr Edmund Kunji in the MRC Mitochondrial Biology Unit of the University of Cambridge.

The postholder will work within a programme focussed on mitochondrial transporters. Transport processes are crucial for the functioning of mitochondria and mutations in transport proteins cause of a wide range of metabolic, neuromuscular and developmental diseases. Basic molecular understanding of their structure and mechanism is required to understand their role in health and disease.

The goal of the project is to study their structures in different conformational states by electron cryo-microscopy and/or x-ray crystallography. The post-holder will participate in every stage of the process, from the generation of expression strains or cell lines, isolation of mitochondria, purification and sample preparation, data acquisition and processing, and structure model building and interpretation. There will also be an opportunity to study their role and mechanism using a wide range of biochemical and biophysical techniques. This project is part of a collaborative SNF Sinergia grant together with Profs. Hediger and Lochner of the University of Bern.

Candidates will have a PhD in Structural Biology/Biophysics or related disciplines, and a track record of research achievements. Knowledge of protein purification and experience in structural biology are essential.

The MRC Mitochondrial Biology Unit is a world-renowned centre for mitochondrial research. Additional information can be found at www.mrc-mbu.cam.ac.uk.

Fixed-term: The funds for this post are available for 3 years in the first instance.

The closing date for applications is Wednesday 12th June 2019 with interview date yet to be confirmed.


[Post Date: May 15, 2019]

Title: MX Support Scientist Diamond Light Source
Website: https://vacancies.diamond.ac.uk/vacancy/mx-village-senior-support-scientist-383573.html

Description:
We are recruiting a senior support scientist to join the MX group at Diamond Light Source. The role involves developing and supporting the very active MX groups user programme, user support for our international user community, training and providing operational support to the group. Opportunities exist to work with us on developing automated systems for data collection and associated supporting infrastructure.

Closing date for applications is Sunday 2nd June.


[Post Date: May 13, 2019]

Title: Full Professor University of Graz
Website: https://jobs.uni-graz.at/en/BV/11/98/4928

Description:
The University of Graz is currently seeking to appoint a full professor
(m/f) of biophysics. The main focus of the professorship will be molecular and cellular biophysics and it is thematically and organizationally embedded in the division of Biophysics and Structural Biology at the Institute of Molecular Biosciences. Possible topics are:
biophysical and structural studies of cellular membrane and/or organelle systems or investigations of protein-membrane and protein-lipid interactions with respect to cell biological and physiological processes.

Graz is a very attractive city in the southeast of Austria with an extremely active research environment in the biosciences, which benefits greatly from the intensive cooperation of the three universities (University of Graz, Graz University of Technology and Medical University Graz).

More detailed information on this opening and the application procedures can be found at: https://jobs.uni-graz.at/en/BV/11/98/4928

The deadline for the application is June 10, 2019.


[Post Date: May 13, 2019]

Title: Postdoc Brown University
Website: https://deaconesculab.com

Description:
The Deaconescu Lab at Brown University has one opening for a postdoctoral researcher. The laboratory's interest is the interplay between DNA repair and other cellular processes including transcription and chromatin remodeling, and is focused on elucidating the function and mechanochemistry of DNA-based motors using a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, small-angle X-ray scattering, transmission electron microscopy). For examples of work, please see Dorich V et al. Genes & Development (in press), Le TT et al. Cell (2018), Vemu A et al. Science (2018), Kutter et al. JMB (2016), Szyk et al, Cell (2014), Deaconescu et al., PNAS (2012) and Szyk et al., NSMB (2012).

A successful candidate would be proficient with specimen preparation, data collection as well as the processing of data acquired using electron cryo-microscopy or X-ray crystallography and should also have the following qualifications: a Ph.D. in the field of structural biology or a related field; an established track-record of publications in peer-reviewed journals. Experience in protein biochemistry would be a plus, but training and technical assistance will be provided if the project requires it. Must be highly motivated and work independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply.

Interested candidates should send a CV, one page research experience summary and contact information for three references to alexandra_deaconescu@brown.edu. Position is available immediately. Please write Postdoctoral Candidate in the e-mail subject header. Brown University, an Ivy League school, is located less than one hour away by train from Boston.


[Post Date: May 11, 2019]

Title: Postdoc EMBL Hamburg
Website: http://s.embl.org/HH00169

Description:
We are currently looking for a highly motivated molecular biologist with protein biochemistry expertise to develop the use of single domain antibodies as a platform technology for structural and functional studies.

At the EMBL Hamburg unit. The research portfolio of the Hamburg Unit is mainly focused on structures of membrane proteins and large protein complexes by diverse structural biology approaches including X-ray
crystallography and cryo-electron microscopy. The successful candidate will work in a collaborative environment together with structural and computational biologists. You will be affiliated with the research group of Christian Löw.

The Löw laboratory is specialized in structural biology of integral membrane proteins. The team uses innovative approaches to study the structure and dynamics of nutrient uptake systems.

Further information about the position can be obtained under the following link: http://s.embl.org/HH00169


[Post Date: May 08, 2019]

Title: Postdoc University of Texas McGovern Med School

Description:
A postdoctoral position is available in the Department of Biochemistry and Molecular Biology at University of Texas McGovern Medical School in the laboratory of Dr. Lei Zheng to study the structure and regulatory mechanism of mammalian sodium/calcium exchanger proteins using X-ray crystallography and cryo-electron microscopy.

Sodium/calcium exchanger proteins are involved in maintaining Ca2+ homeostasis in most mammalian tissues and play essential roles in cardiac contraction-relaxation and neuronal transmission. The successful candidate will perform protein expression and purification using insect cell systems, and use cryo-electron microscopy and single particle analysis approaches to study the structure of exchanger complex with small drug inhibitors. The fellow will also use X-ray crystallography and other biochemical approaches to study a novel regulatory mechanism of exchangers mediated by accessory proteins newly identified in our lab.

The ideal candidate should have a recent Ph.D. in Structural Biology and Biochemistry with demonstrated experience in protein expression, purification and characterization. Experience with membrane protein and insect cell culture will be a great asset. The fellow will have an opportunity to work other groups in the department to learn cryo-Electron Microcopy.

The laboratory is located in Texas Medical Center, the largest campus for medical research in the world, which provides outstanding environments for academic development. Houston is a highly culture-diversified city with affordable living costs. Salary will be based on NIH standard and individual experience.

Interested applicants should send their CV and three letters of reference to Dr. Lei Zheng (lei.zheng@uth.tmc,edu).


[Post Date: May 08, 2019]

Title: Postdoc Exeter University

Description:
A postdoctoral position is available on a multidisciplinary project between the group of Prof Littlechild at the Henry Wellcome Building for Biocatalysis and Prof Frank Volmer in Physics within the new LSI Building in association with the Physics Department. The aim is to study enzyme structure, stability and mechanism, and enzyme folding with state-of the art methodologies including single-molecule optical nanosensors, X-rays, and molecular dynamics simulations. This project will be part of the UKRI Molecular Mechanics Initiative at the University of Exeter which is a cutting-edge research programme that aims to achieve breakthroughs in how to detect, analyse, and manipulate molecules at the ultimate single-molecule level.

Experience with gene cloning and over-expression, enzyme purification, X-ray structural analysis, mutational analysis and application of other biophysical techniques is required. Familiarity with surface immobilisation of proteins and enzymes, molecular dynamics simulations, Raman and SERS protein analysis, and electrochemical sensors is desirable.
The successful candidate can be appointed as Postdoctoral Research Fellow (Grade F) depending on the skills and experience the individual can bring to the role.

Postdoctoral Research Fellow on Grade F from £35,211 up to £39,609 per annum. Please find further job specifications on the Exeter web site and any interested candidates should apply by the closing date of 28th May. For further information, please contact Prof J Littlechild, email J.A.Littlechild@exeter.ac.uk, or telephone (01392) 7223468.


[Post Date: May 08, 2019]

Title: Postdoc Rutgers University
Website: https://plantbiology.rutgers.edu/faculty/tumer/Nilgun_Tumer.html

Description:
A postdoctoral position is available at the Department of Plant Biology at Rutgers University in the laboratory of Dr. Nilgun E. Tumer for an NIH funded collaborative project with the Institute for Quantitative Biomedicine to identify small molecule and peptide inhibitors against Shiga toxin 2 (Stx2). Shiga toxin (Stx) producing E. coli (STEC) and Shigella are foodborne pathogens that cause diarrheal disease in millions of people around the world. They remain a major challenge for food safety and public health because there are no specific therapeutics or vaccines against infection by bacteria producing Shiga toxins.

Stxs depurinate the sarcin/ricin loop of the large rRNA and inhibit translation. E. coli strains producing Stx2 are associated with more severe disease than strains producing Shiga toxin 1 (Stx1). We showed that the A1 subunit of Stx2 has higher affinity for ribosomes and higher catalytic activity than the A1 subunit Stx1 (Basu, D. et al., 2016, Infect. Immun. 84:149-161) and identified the residues critical for ribosome binding (Basu, D. et al., 2016, Infect. Immun. 84:3290-3301). Our goal is to develop inhibitors that disrupt the activity of Stx2 by inhibiting its interaction with the ribosome. We have used surface plasmon resonance-based fragment screening to identify fragments that bind to Stx2.

The successful candidate will perform protein expression and purification using bacterial systems and will perform X-ray crystallography of inhibitors bound Stx2 to help optimize them into more potent leads. Phage display will also be used to identify peptides that bind to Stx2. The Stx2 inhibitory activity of these peptides will be investigated in cell-free and cell-based assays.

The ideal candidate should have a Ph.D. in Structural Biology and Biochemistry and experience in protein expression, purification and characterization, and crystallization, and X-ray crystallographic structure determination and refinement, and be interested in developing skills in phage display and learning cryo-Electron Microcopy, which will be carried out in collaboration with the Institute for Quantitative Biomedicine at Rutgers.

Interested applicants should apply online through the ROCS system of Rutgers University and in addition send their CV and three letters of reference to Dr. Nilgun E. Tumer (tumer@sebs.rutgers.edu) and Dr. Xiao-Ping Li (xpli@sebs.rutgers.edu).


[Post Date: May 08, 2019]

Title: Postdoc IBS/Grenoble

Description:
We have immediate openings for two postdoctoral researchers and one PhD student at the Institut de Biologie Structurale (www.ibs.fr) in Grenoble, France, to study the structural dynamics of light-sensitive proteins by time-resolved serial crystallography at XFELs and potentially future 4th generation synchrotrons.

Serial femtosecond crystallography (SFX) at X-ray free electron lasers (XFEL) allows studying the structural dynamics of crystalline proteins by means of time-resolved crystallography (TR-SFX). We apply TR-SFX to explore conformational changes after photon absorption by various light-sensitive proteins on a broad time scale ranging from sub-picoseconds to seconds (Nature Chemistry 10, 31 (2018)). These animate structures obtained by static SFX (J Phys Chem Lett 7, 882 (2016); Nature 539, 43 (2016).
At the postdoctoral level, we are looking for highly motivated individuals with a proven record in macromolecular crystallography with a keen interest in data processing and handling and intermediate-state structure refinement.

At the PhD level, we welcome applications from students trained in protein biophysics, and preferably in crystallography.

If you are interested, please contact either Martin Weik (weik@ibs.fr) or Jacques-Philippe Colletier (colletier@ibs.fr).


[Post Date: May 08, 2019]

Title: Scientist/Senior Purification Scientist Evotec
Website: https://recruitment.evotec.com/home.aspx

Description:
Evotec is a leader in the discovery and development of novel small molecule drugs with operational sites in Europe and the US. The Company has built substantial drug discovery expertise and an industrialised platform that can drive new innovative small molecule compounds into the clinic. In addition, Evotec has built a deep internal knowledge base in the treatment of diseases related to neuroscience, pain, oncology, inflammation and metabolic diseases. Leveraging these skills and expertise the Company intends to develop best-in-class differentiated therapeutics and deliver superior science-driven discovery alliances with pharmaceutical and biotechnology companies.

We are looking for a highly motivated individual for our Abingdon site to work as a

Scientist/Senior Purification Scientist, Structural Biology

Evotec (UK) Ltd is currently seeking to add to our Structural Biology Department. The group works closely with our Discovery Chemistry Department and with clients to develop novel small molecule drugs. The group is at the forefront of new science and technology, and is seeking to expand as business needs grow.

Required Knowledge, Skills and Abilities:
• Extensive knowledge of protein purification, demonstrated through the delivery of innovative solutions for drug discovery programs
• A working knowledge and practical experience with AKTA systems will be highly advantageous
• The successful candidate will have experience working in multi-disciplinary teams
• Experience collaborating with scientists in external organisations would be an advantage

Responsibilities may include:
• Supporting a project team by conducting experiments with defined, agreed objectives and timelines
• Contributing to the design, execution and interpretation of experiments in a project team to accomplish project goals
• Adapting scientific knowledge to resolve problems encountered in achieving defined goals with assistance from line manager or other team members to meet internal and project deadlines
• Preparing reports of findings, presenting data, and collaborating with other scientists at Evotec
• Presenting own work at project technical meetings, and department technical meetings when required
• Demonstrating full command of all techniques and tools required for assigned responsibilities within the given project
• Ensuring safe working practices of themselves and any direct reports
• Complying fully with the company safety policy (including COPs and SOPs) when performing experiments
• Reading scientific literature relevant to the project
• Adhering to Lab Notebook guidelines regarding accurate documentation of lab experiments

Desirable Knowledge, Skills and Abilities:
• Self-motivated, enthusiastic, cooperative and reliable
• Knowledge of basic laboratory techniques, and understanding of the science underlying the techniques and experiments
• Experience of working in a lab environment
• The ability to adapt to changing demands whilst operating under pressure to deadlines
• The ability to work accurately and with attention to detail
• Good interpersonal skills and the ability to work well with other scientific staff
• The ability to work well independently, and as part of a team
• Good organisational and time management skills
• Good verbal communication skills
• Ability to maintain excellent laboratory records
• Computer proficiency

Education and Experience:
• PhD, MSc, BSc degree or equivalent in Biochemistry or related area

If you are interested in this position, please visit Evotec’s Career Page at https://recruitment.evotec.com/home.aspx


[Post Date: May 08, 2019]

Title: Research Associate University of Cambridge
Website: http://www.jobs.cam.ac.uk/job/21171/

Description:
Molecular mechanisms of meiotic recombination

A postdoctoral position is available in the group of Prof. Luca Pellegrini in the Department of Biochemistry of the University of Cambridge, to work on meiotic recombination, the cellular process responsible for generation of sexual diversity and fertility. The project focuses on the molecular mechanisms that establish the functional architecture of meiotic chromosomes and promote strand exchange between parental DNA (Syrjänen et al., eLife, 2014; Syrjänen et al., eLife, 2017).

Suitable candidates will hold or be about to receive a PhD in Biochemistry, Biophysics or Molecular Biology. They will be highly motivated to pursue an exciting and challenging project in basic research, and will be able to demonstrate an excellent track record of relevant achievements. Experience in the biochemical reconstitution and biophysical analysis of macromolecular complexes is important. In addition, familiarity with experimental methods in cryo-electron tomography would be an advantage.

The position is available from June 2019, and is funded for three years in the first instance. Applicants should submit a CV with list of relevant publications, a cover letter explaining why they are suitable for the position and the contact details of at least two referees.

To apply, go to: http://www.jobs.cam.ac.uk/job/21171/

Informal enquiries can be made by contacting Luca Pellegrini (lp212@cam.ac.uk)
https://www.bioc.cam.ac.uk/people/uto/pellegrini

Enquiries about the application process can be sent to the HR team at personnel@bioc.cam.ac.uk. Please quote reference PH18815 on your application and in any correspondence about this vacancy.
The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


[Post Date: May 06, 2019]

Title: Postdoc Karolinska Institute

Description:
A postdoctoral position is available at the Department of Medical Biochemistry and Biophysics (MBB), Division of Chemistry 2, Karolinska Institute, Stockholm. The project is focused on overexpression, purification, and crystallization of human integral membrane enzymes involved in the generation of lipid mediators of inflammation, all of which are drug targets.

MBB is one of the largest departments at Karolinska Institutet equipped with a range of state-of-the-art technologies in basic research, in particular, structural biology, proteomics, imaging, and animal models. It hosts world-leading groups in areas such as molecular neurobiology, matrix biology, vascular biology, redox regulation, and lipid mediators of inflammation, which together create a vibrant research environment.

A prospective candidate should hold a recently obtained PhD in structural biology, biochemistry or a related area and a strong background in protein chemistry, crystallization and structure determination by X-ray crystallography and/or Cryo-EM, specifically membrane proteins. The position is initially available for 2 years with a possibility of extension.

Interested candidates should send a letter of intention and CV including references as a single PDF file by email to jesper.haeggstrom@ki.se and
madhuranayaki.thulasingam@ki.se. The position will remain open until filled.


[Post Date: May 03, 2019]

Title: Research Assistant
Website: https://www.unibz.it/en/home/position-calls/positions-for-academic-staff/4094-chimica-organica-dr-benini?group=18

Description:
A 3 years Research assistant position (1+1+1) is available at the Free University of Bolzano to work in my group on the Euregio IPN95 project:

“Siderophore mediated iron uptake in Erwinia amylovora and Aspergillus fumigatus. Towards new strategies in plant and human health”

The project is in collaboration with Professor Hubertus Haas, Medical University Innsbruck, and Professor Sheref Mansy, University of Trento.

To apply for the position follow the link:

https://www.unibz.it/en/home/position-calls/positions-for-academic-staff/4094-chimica-organica-dr-benini?group=18

Some background information on one of the system to study could be found in this publication:

https://doi.org/10.1016/j.jsb.2018.02.002

Deadline for application is June 4, 2019


[Post Date: May 03, 2019]

Title: Postdoc University of Illinois at Chicago
Website: https://jobs.uic.edu/job-board/job-details?jobID=113640&job=visiting-research-specialist-biological-sciences

Description:
NIH/NSF-Funded Research Specialist Position in Structural Biology at the University of Illinois at Chicago

The Polikanov Laboratory at the University of Illinois at Chicago (IL, USA) is looking for talented, skillful, and highly motivated researchers to fill the NIH/NSF-funded Visiting Research Specialist positions to study the structure and function of the bacterial ribosome.

The research in the Polikanov Laboratory is focused on understanding the basic principles of protein synthesis in bacteria, the modes of action of ribosome-targeting antibiotics, and the mechanisms of drug resistance at a structural level. More information about Dr. Polikanov research can be obtained from the most recent publications (https://www.ncbi.nlm.nih.gov/sites/myncbi/yury.polikanov.1/bibliography/50395623/public/?sort=date&direction=descending) or found on the laboratory web-page (https://bios.uic.edu/bios/people/faculty/yury-polikanov). The successful candidate will be involved in determination of high-resolution structures of ribosome functional complexes with various protein translation factors, tRNAs, and antibiotics using macromolecular X-ray crystallography techniques.

Basic qualifications:
• BS degree in chemistry, biochemistry, biophysics, or a related field is required;
• MS degree or higher is preferred;• Minimum of 3 years of laboratory research experience is required;
• Strong background in biochemistry and molecular biology is required;
• Practical skills with the most standard methods currently used in molecular biology, and biochemistry (such as protein expression, purification);
• Experience in structural biology (cryo-EM or X-ray crystallography) is not required but is highly desirable;
• Experience in RNA biology field is not required but is highly desirable;

The successful candidate is also expected to:
• Act independently in terms of planning and executing the experiments;
• Compile, analyze, and prepare data for publications;
• Assist with training of graduate and undergraduate students.

Interested candidates should submit their CV, cover letter, and contact information for three references at https://jobs.uic.edu/job-board/job-details?jobID=113640&job=visiting-research-specialist-biological-sciences by June 28, 2019. Cover letter should be describing how previous research accomplishments and scientific interests of a candidate fit with the scope of the research in the Polikanov Lab.

The University of Illinois at Chicago is an Equal Opportunity, Affirmative Action employer. Minorities, women, veterans and individuals with disabilities are encouraged to apply.
The University of Illinois may conduct background checks on all job candidates upon acceptance of a contingent offer. Background checks will be performed in compliance with the Fair Credit Reporting Act


[Post Date: May 01, 2019]

Title: Research Assistant SGC University of Oxford
Website: https://www.thesgc.org/careers/oxford/sgc-oxford-research-assistant-membrane-proteins-0

Description:
Research Assistant Position (application deadline: May 23, 2019):

We are seeking a highly motivated Research Assistant to provide molecular biology, eukaryotic (insect and mammalian) expression and protein production support for a collaborative project, the aims of which are to unlock Solute Carrier Proteins (SLCs). SLCs are integral membrane proteins which are challenging to express and purify. Therefore, we are seeking someone with creativity in devising both generic and specialised solutions for difficult proteins.

The Research Assistant will be working closely with other researchers in the Biotechnology Group and the Membrane Protein Structure & Function Group at the Structural Genomics Consortium Oxford and collaborate with academic and pharma partners within ReSOLUTE (Research empowerment on solute carriers).

ReSOLUTE is a public-private research partnership with 13 international partners from academia and industry supported by the Innovative Medicines Initiative (IMI) (https://re-solute.eu/consortium). A major objective of this research is the recombinant production of human SLC family members to generate antibodies and other affinity reagents, such as camelid single-domain nanobodies and sybodies. These affinity reagents are powerful tools that can be used as crystallization chaperones for X-ray crystallography, to modulate transport in functional assays and to facilitate single-particle cryo-electron microscopy.

For more information please visit this link above.


[Post Date: April 30, 2019]

Title: Structural Biologist II Ambry Genetics
Website: https://tinyurl.com/yy7cqmwd

Description:
Description

The job’s main responsibility is to collaborate with Bioinformaticians, Clinicians, and Researchers to design and perform data-science driven analyses relating to mechanisms of pathology in the clinical setting.

Position Duties and Responsibilities:

Provide structural biology support for variant analyses by analyzing and interpreting structural-function relationships
Develop new methods and protocols for structural modeling
Perform data science intensive analyses of the mechanisms driving clinical pathology
Validation of new methods, including data collection and analysis algorithms, experience with machine learning is a plus
Develop features/tools assisting clinical and genetic analysis on in house analysis platform
Support Bioinformatics, R&D, and the Reporting Teams for clinical research projects

Position Requirements:

PhD degree in computational biology, biophysics, bioinformatics, or data science
Familiar with, biological pathways, and genomics
Knowledge of current theories and principals of computational biology and data science
At least 2 year research and development in related computational fields
Familiarity with methods and skills involved with rigorous software development practices such as version control software (Git, Mercurial, OpenCVS) and test-driven software development.
Proficiency with Python, R, or C/C++, and SQL
Excellent oral and written communication skills
Ability to work within a team, among departments, and as an independent contributor, requiring minimal supervision

AMB123

About Us:

Ambry Genetics Corporation is a CAP-accredited and CLIA-licensed molecular genetics laboratory based in Aliso Viejo, California. We are a genetics-based healthcare company that is dedicated to open scientific exchange so we can work together to understand and treat all human disease faster.

At Ambry, everyone is welcome. A career at Ambry Genetics is a chance to be part of a dynamic company that aims to improve health by understanding the relationships between genetics and human disease. We earned our reputation as industry leaders by responsibly introducing cutting-edge genetic testing solutions and continually sharing what we learn with the global scientific community. We also support those with genetic conditions through the Mauli Ola Foundation and other nonprofit organizations.

At Ambry you will be learning, challenging yourself, and having fun while collaborating with teammates through the open exchange of ideas. Employees at Ambry Genetics have many perks, including an onsite café with complimentary smoothies and infused waters! We also offer access to gym memberships, onsite food trucks, “Lunch and Learns,” and more. Our outstanding benefits program includes medical, dental, vision, 401k, FSA, and generous paid time off (PTO) program. Ambry Genetics is an Equal Opportunity Employer (EOE) and we maintain a drug-free work environment.

Ambry Genetics is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Qualifications
Education

Required

PHD or better in Computational Chemistry or related field.


[Post Date: April 26, 2019]

Title: Postdoc SLAC National Accelerator

Description:
PostDoc Position in Membrane Protein Structural Biology at SLAC National Accelerator Laboratory, Stanford University

The position is available immediately in the Biosciences Division at SLAC National Accelerator Laboratory and is initially limited to 2 years, with a possible extension to up to 3.5 years.

Our research focuses on the structural biology of important membrane proteins, using single particle cryoEM and X-ray crystallography. We are working in close collaboration with the groups of Wah Chiu, Soichi Wakatsuki and other experts at SLAC and the Stanford School of Medicine. External collaborations include the group of Vadim Cherezov (USC) and Dirk Slotboom (Univ of Groningen).

SLAC National Accelerator Laboratory is a U.S. Department of Energy (DOE) Office of Science laboratory operated by Stanford University and has a unique set of large-scale facilities including:

- Electron microscopy (3x 300 kV Titan Krios with VPP, equipped with K2/K3 detectors, GIF Quantum energy filter, and 1x 200 kV Talos Arctica)
- Linac Coherent Light Source (LCLS), Hard X-ray Free-Electron Laser
- Stanford Synchrotron Radiation Lightsource (SSRL)
- High performance computing
- Brand new biochemistry laboratory, fully equipped for molecular biology and protein biochemistry

Qualified candidates must have a Ph.D. degree with a solid background in structural biology and biophysics/biochemistry. Previous work with membrane proteins is a plus, but not required. A successful candidate is expected to be highly skilled and self-motivated and is willing to work in a collaborative environment. The Postdoctoral salary depends on qualifications and relevant experiences according to Stanford standards.

Interested candidates should apply directly with Cornelius Gati at cgati[at]stanford.edu. Please attach a cover letter, Curriculum Vitae, research statement, publication list and two reference letters. The deadline for the application is June 30th 2019.


[Post Date: April 26, 2019]

Title: Research Associate II
Website: https://leidosbiomed.csod.com/ats/careersite/jobdetails.aspx?site=4&c=leidosbiomed&id=439

Description:
The Frederick National Laboratory for Cancer Research is hiring a Research Associate II (Structural Biology). The RA-II will work in the NCI RAS Initiative program to support our mission in understanding RAS biology and developing lead compounds against RAS-driven cancers. Basic qualification is a Bachelor's degree with 5 years of experience in biomedical research.

For detailed information and to apply for this position, please use this link:
https://leidosbiomed.csod.com/ats/careersite/jobdetails.aspx?site=4&c=leidosbiomed&id=439


[Post Date: April 22, 2019]

Title: Postdoc Cleveland Clinic C3TD
Website: https://www.lerner.ccf.org/c3td/careers/

Description:
Title: Postdoc Cleveland Clinic Center for Therapeutics Discovery
Website: https://www.lerner.ccf.org/c3td/careers/

Description:
The Center for Therapeutics Discovery (C3TD) was recently established with the mission to promote the translation of basic science discoveries by Cleveland Clinic researchers into new therapeutics. We have established a pipeline of innovative research programs directed toward improving patient care with a true bench-to-bedside vision. To achieve these goals, we use state of the art technologies in small molecule library screening, fragment-based methods, X-ray crystallography, computational tools, and target validation towards generating starting points for nascent hit-to-lead and lead optimization campaigns.

Postdoctoral structural biologists will have the opportunity to aid in the discovery and development of small molecule inhibitors across multiple disease areas, including oncology, inflammation, cardiovascular and neuroscience. Structural biology fellows will play a vital role in the drug discovery process by solving novel protein structures and protein-ligand complexes, thereby enabling structure-based drug design. Additionally, fellows will help with the development of biochemical assays for the purpose of small molecule drug screening, target validation, and SAR campaigns. This position offers the ability to work on a variety of therapeutically relevant proteins, protein-protein complexes and extensive opportunities to collaborate with CC researchers.

Candidates should have a PhD in biochemistry, chemistry, structural biology, or related field. Extensive experience in structure determination using X-ray crystallography, protein NMR and/or cryo-EM is required. For more information and how to apply, please visit https://www.lerner.ccf.org/c3td/careers/

Cleveland Clinic’s Lerner Research Institute is the biomedical research institute of the Cleveland Clinic and represents 1,400 researchers and support personnel in 180 laboratories across 12 departments. The Lerner is one of the largest research institutes in the nation, consistently ranking in the top 10 in National Institutes of Health funding, a benchmark of research success.


[Post Date: April 19, 2019]

Title: Beamline Scientist

Description:
Synchrotron Beamline Scientist
The New York Structural Biology Center (NYSBC) is a shared research organization, owned and operated by nine eminent research universities and medical schools in the New York area. NYSBC is devoted to advancing structural and functional characterization of biological processes through technology development for cutting-edge biomedical research. X-ray crystallography is a crucial component of NYSBC activity, and the NYX Microdiffraction Beamline has been developed by NYSBC at the National Synchrotron Light Source II (NSLS-II) to support this work.

NYSBC seeks a Scientist to join the NYX beamline team for NSLS-II sector 19-ID at Brookhaven National Laboratory (BNL) to help steer further development of macromolecular crystallography at NYX. The new scientist will be employed by NYSBC organization and stationed at its NYX beamline at NSLS-II. The successful candidate will establish relevant research projects in collaboration with NYSBC scientists, groups at its constituent institutions, or with BNL structural biologists and other groups. These projects will exploit the unique qualities of the NYX beamline and can be coordinated with the NSLS-II life science programs.

Responsibilities will include interacting and assisting the scientific user community and visiting scientists with their data collections and structure solving. In addition, the new scientist will advance the beamline’s technical capabilities by initiating or conceiving upgrades of its hardware and software for the benefit of the structural biology community at NYSBC and beyond.
Salary level will be commensurate with qualifications and experience.

Required Knowledge, Skills and Abilities:
• B.S. or equivalent degree in biophysics, physics, chemistry or related field
• Three years of prior experience relevant to NYX activities described above
• Excellent written and oral communications skills
• The ability to interact effectively in a team environment with a diverse group of scientists, engineers, technical staff, and users
Preferred Knowledge, Skills, and Abilities:
• Ph.D. degree in biophysics, chemistry, or related field
• Three years of prior experience in data acquisition for macromolecular structure determination, including the use of synchrotron radiation
• Strong publication record in diffraction analysis
• Experience with X-ray optics, X-ray detectors, and/or software for crystallographic computing
• Demonstrated success in leading scientific or technical groups or projects.

Direct inquiries and applications, including cover letter and CV, to
Wayne Hendrickson (wah2@cumc.columbia.edu), Scientific Director, NYSBC, or to Dieter Schneider (schneider@bnl.gov), Chief Beamline Scientist for NYX


[Post Date: April 18, 2019]

Title: Beamline Scientist SwissFEL
Website: https://www.psi.ch/pa/stellenangebote/2000

Description:
Tenure-track beamline scientist position in macromolecular crystallography group at the Photon Science Division, Paul Scherrer Institut (https://www.psi.ch/macromolecular-crystallography/). This position offers a unique opportunity to develop and operate a dedicated serial femtosecond crystallography (SFX) station at the SwissFEL. Detailed information and the online application portal can be found at https://www.psi.ch/pa/stellenangebote/2000.



[Post Date: April 18, 2019]

Title: Postdoc University of Cambridge
Website: http://www.jobs.cam.ac.uk/job/21171/

Description:
Molecular mechanisms of meiotic recombination

A postdoctoral position is available in the group of Prof. Luca Pellegrini in the Department of Biochemistry of the University of Cambridge, to work on meiotic recombination, the cellular process responsible for generation of sexual diversity and fertility. The project focuses on the molecular mechanisms that establish the functional architecture of meiotic chromosomes and promote strand exchange between parental DNA (Syrjänen et al., eLife, 2014; Syrjänen et al., eLife, 2017).

Suitable candidates will hold or be about to receive a PhD in Biochemistry, Biophysics or Molecular Biology. They will be highly motivated to pursue an exciting and challenging project in basic research, and will be able to demonstrate an excellent track record of relevant achievements. Experience in the biochemical reconstitution and biophysical analysis of macromolecular complexes is important. In addition, familiarity with experimental methods in cryo-electron tomography would be an advantage.

The position is available from June 2019, and is funded for three years in the first instance. Applicants should submit a CV with list of relevant publications, a cover letter explaining why they are suitable for the position and the contact details of at least two referees.

To apply, go to: http://www.jobs.cam.ac.uk/job/21171/

Enquiries about the application process can be sent to the HR team at personnel@bioc.cam.ac.uk. Please quote reference PH18815 on your application and in any correspondence about this vacancy.
The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


[Post Date: April 16, 2019]

Title: Postdoc University of South Carolina

Description:
A postdoctoral position is available for a highly motivated biochemist/structural biologist interested in studying molecular mechanisms of cell signaling by ubiquitin and ubiquitin-like proteins. Available projects in the laboratory provide excellent training opportunities as they involve a multidisciplinary approach that combines X-ray crystallography, cryo-electron microscopy, biochemical/biophysical techniques, and cell-based assays.

Candidates should hold a recently obtained PhD in structural biology, biochemistry, or a related area and should be skilled in standard molecular biology techniques and recombinant protein expression and purification. Candidates with demonstrated expertise in X-ray crystallography and/or single particle cryo-electron microscopy are preferred.

Interested candidates should e-mail a cover letter, CV, and the names of three references to olsensk@musc.edu. The position will remain open until filled.


[Post Date: April 15, 2019]

Title: Fellowships Scientific Institute San Raffaele

Description:
The Biocrystallography Unit of the IRCCS Scientific Institute San Raffaele in Milan is looking for:

One junior research fellow to study the biochemical and structural features of a G-protein coupled receptor involved in the remyelination of the central nervous system, within the framework of a multicentric project funded by a two-year grant from the Italian Multiple Sclerosis Foundation (FISM).

One post-doctoral research fellow to study the biochemistry and structural basis of self-recognition by B-cell receptors derived from chronic lymphocytic leukaemia patients. The project involves the structural determination to high resolution of the BCRs, the characterization of their mutual binding, and the development of antagonists based on the 3D structures (Minici et al., Nat Commun 2017). The position is funded by a three-year grant from Worldwide Cancer Research.

The successful candidates will join a dynamic group of structural biologists within one of the top-rated biomedical research institutions in Europe to perform structural and functional studies using a combination of biophysical techniques (SPR, ITC, AUC), mutagenesis, cell-based assays, X-ray crystallography and cryo-EM. We are searching for someone with a strong interest in the structure-function relationship of biological macromolecules that is creative, hard-working and willing to tackle challenging, high-rewarding projects.

Salary will be commensurate to experience. Your application should be sent to degano.massimo@hsr.it including your curriculum vitae, a 1-page personal statement on previous experience and your research interests, name and email address of former supervisor(s) that can provide reference.


[Post Date: April 15, 2019]
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