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Macromolecular Crystallography at SSRL
- Using the SSRL Automated Mounting (SAM) system
Robotic Sample Handling
- The universal puck project
Avidien
- microPro 300 Benchtop 96 Channel Pipettor
CyBio SELMA
- Semi-automatic 96- or 384-fold pipettor with Minimal required space
Douglas Instruments
- Automatic Protein Crystallization Systems
Formulatrix
- Protein crystallization automation solutions
Hudson Lab Automation ARI
- Imaging and liquid handling for protein crystallization
Integra
- VIAFLO 96 and VIAFLO 384 - Handheld 96- and 384-channel pipette
TTP Labtech
- Mosquito nanoliter liquid handling for crystallization
Brady
- Product identification solutions (Bar code readers)
Zebra Technologies
- Scanners
Asinex
- Libraries and building blocks inspired by nature
ChemBridge
- Smal molecule screening libraries and building blocks
Practical macromolecular cryocrystallography
- J.W. Pflugrath, Acta Crystallogr F Struct Biol Commun. 2015 Jun 1; 71(Pt 6): 622-642. Published online 2015 May 27.
Oxford Cryosystems
- Cryostream low temperature device.
Agro Design Studios - Agro Box
- Protein/Nucleic Acid Structural Analysis Full Service. Complete X-ray crystal structure analysis. Overseas synchrotron radiation facility measurement service.
Bio-Xtal
- Bio-Xtal is a proteomics service company operating since 1998
Cayman Chemical
- Our structure-based drug design (SBDD) services are supported by medicinal chemistry, computer-aided drug design (CADD), and protein production services. Our structural biology experts, with proven experience in biophysical characterization, X-ray structure determination, and in silico docking analysis, have determined more than 250 high-resolution crystal structures of a variety of targets, advancing drug discovery and development efforts for our clients.
CEITEC Core Facility Biomolecular Interactions and Crystallization
- The core facility provides services leading to biophysical and structure characterization of biomolecules and to study (bio)molecular interactions. It is equipped with the instrumentation to set up crystallization conditions of biomolecules and their complexes, basic characterization of physical properties of the molecules (analytical ultracentrifugation, dynamic light scattering, CD spectroscopy, differential scanning calorimetry, differential scanning fluorimetry), and to study thermodynamics and/or kinetics of interactions (isothermal titration calorimetry, surface plasmon resonance, microscale thermophoresis, CD spectroscopy, analytical ultracentrifugation).
Charles River
- Protein Crystallization & X-ray Crystallography
Collaborative Crystallization Centre (C3)
- Australia's only full-service protein crystallization facility.
Cube Biotech
- Protein Services (including crystallization)
Curia
- Protein and peptide crystallization and structural biology services, as well as biologics, research and development, manufacturing and lab testing.
Crelux
- Your Discovery. Our Solutions.
Evotec
- Drug Discovery Services
Hauptman-Woodward Medical Research Institute Crystallization Screening Service
- The High-Throughput Crystallization Screening Center performs crystal-growth screening experiments in 1536-well microassay plates for both soluble and membrane biological macromolecules. We set up the experiments with a predetermined set of crystallization cocktails, image them weekly over six weeks, and send you those images including SONICC and UV along with analysis software to view them. You send the sample, we do the rest.
Helix Biostructures
- Drug Discovery Services, Built To Atomic Resolution. Helix BioStructures offers a wide range of integrated drug discovery services, including methods in biophysical characterization, structural biology, and medicinal chemistry. Our services have been fine tuned to provide unmatched quality, efficiency, and affordability.
Inixium
- Contract Research Organization providing scientific expertise in Structural Biology.
Kshammalab (OPC) Private Limited
- At Kshammalab (OPC) Private Limited, we bring cutting-edge protein crystallography services to researchers and industries worldwide. From protein crystallization to high-resolution structure determination, we provide end-to-end solutions that accelerate your scientific breakthroughs.
LifeTein
- Protein Crystallography Service: Protein Expression, Crystallization to Structure Determination
Max Planck Institute of Biochemistry Crystallization Facility
- The MPIB Crystallization Facility provides state-of-the-art structural biology infrastructure for researchers working at the Max Planck Institute of Biochemistry as well as co-operation partners at several research institutes in the Munich area. The MPIB Crystallization Facility currently performs about 6500 crystallization experiments per year and is used by 26 research groups. The Crystallization Facility is hosted and managed by the Department of Structural Cell Biology.
Medicilon
- Fully integrated pharmaceutical services for the global scientific community
Nexomics
- Nexomics utilizes proprietary platform technology to offer a broad array of gene-to-structure services to the biopharmaceutical community.
NovAliX
- Your partner for structure-based drug discovery
Paul Scherrer Institut Macromolecular Crystallization Facility
- The Macromolecular Crystallisation Facility at the PSI is maintained by the SLS and the BIO division. The facility is situated at the X06DA beamline. We work with scientists from the BIO division, the SLS, the SwissFEL, and elsewhere, to produce and to optimise macromolecular micro- and nano-crystals for x-ray diffraction experiments at the forefront of structural biology. The facility is equipped for robotic crystallization screening using sitting-drop vapour diffusion or lipidic cubic phase; and to image, analyse, optimise, mount and test crystals grown in those experiments.
Peak Proteins
- Protein expression & production, structural determination
Proteros
- Structure-accelerated lead discovery
Proxychem
- Provider of drug discovery solutions to the pharmaceutical and biotech communities
SARomics Biostructures
- Outsourcing Services: Drug Discovery and Structural Biology Platform
Selvita
- We offer crystallography services from protein production and crystallization to data collection and structure determination, with streamlined protocols and guaranteed reproducibility. We provide high-quality drug discovery and drug development services. We have the necessary expertise and know-how to support drug discovery projects across a broad range of therapeutic areas. We offer a range of stand-alone or fully integrated drug discovery and development solutions spanning the entire value chain from early drug discovery to preclinical development.
Shamrock Structures
- Protein Crystallography, Medicinal Chemistry and Cell Biology Research Services
Syngene
- Your Partner at Every Step of Discovery and Development
UCLA-DOE Crystallization Core
- Macromolecular crystallization services
University of Minnesota Nanoliter Crystallization Facility
- The Nanoliter Crystallization Facility at the University of Minnesota is a joint effort of the University of Minnesota and the Mayo Clinic funded in part by a grant from the state of Minnesota and the NIH. The purpose of this facility is to aid researchers at these institutions by providing access to a high throughput, low sample volume, crystallization facility which will in turn increase access to x-ray crystallography and the determination of 3D atomic structures of biological macromolecules.
University of Zurich Protein Crystallization Center - PCC
- he Protein Crystallization Center – PCC@UZH – supports the structural biology research community by setting up and monitor high-throughput protein crystallization experiments at the nano-liter scale. PCC@UZH offers as a service a wide range of crystallization techniques for soluble and membrane proteins. The crystallization service is open to all academic research groups and to private industry.
UQ ROCX - Remote operation crystallization and X-ray diffraction facility
- The Remote operation crystallization and X-ray diffraction facility (UQ ROCX) is part of the Centre for Microscopy and Microanalysis (CMM) and is located in the Queensland BioScience Prescinct at The University of Queensland.
Zenobia Therapeutics
- Dedicated to finding disease modifying treatments for unmet medical needs in the nervous system
Crystal Growth 101
- A collection of articles covering a wide array of crystallization topics
Protein Crystallization Tutorial
- By Terese Bergfors
X-Tal Protocols
- By Johan Zeelan
Binding Database
- Measured binding affinities for biomolecules, genetically or chemically modified biomolecules, and synthetic compounds.
BMCD
- Biological Macromolecular Crystallization Database
BRENDA
- The Comprehensive Enzyme Database
ExPASy Proteomics Tools
- The ExPASy (Expert Protein Analysis System) proteomics server of the Swiss Institute of Bioinformatics (SIB) is dedicated to the analysis of protein sequences and structures as well as 2-D PAGE.
JAXA Cryoprotectant database for protein crystals
- Cryoprotectant database for protein crystals
PubMed
- PubMed comprises more than 29 million citations for biomedical literature from MEDLINE, life science journals, and online books.
LipidBank
- he official database of Japanese Conference on the Biochemistry of Lipids (JCBL)
Membrane Proteins of Known Structure
- Fom the Stephen White laboratory at UC Irvine
Heavy Atom Databank
- This databank will be of interest, not only to protein crystallographers but to anyone interested in the interaction of heavy-atoms with proteins.
Nucleic Acid Database Project
- A Portal for Three-dimensional Structural Information about Nucleic Acids
Nucleic Acid Knowledgebase
- The Nucleic Acid Knowledgebase (NAKB), new portal for 3D structural information about Nucleic Acids, is the planned successor to the Nucleic Acid Database (NDB), as described in this recent review:
Berman HM, Lawson CL, Schneider B (2022) Developing Community Resources for Nucleic Acid Structures. Life 12, 540. DOI
NAKB provides search, report, statistics, atlas and visualization pages for all nucleic-acid containing experimentally determined 3D structures held by NDB and by the Protein Data Bank (PDB), including all major methods: X-ray, NMR, and Electron Microscopy. For each structure, links are provided to external resources that annotate and analyze nucleic acid structures and their complexes.
Structural Biology Software Database
- This database contains programs which are thought to be of interest to researchers in the fields of structural biology, quantum chemistry, and bioinformatics.
PDB
- Protein Data Bank
PDB Ligand Expo Search
- Chemical component search tools
Protein Data Bank in Europe
- Bringing Structure to Biology
PubChem
- PubChem provides information on the biological activities of small molecules.
Scratch Protein Predictor
- Scratch Protein Predictor
Worldwide PDB Protein Data Bank
- Since 1971, the Protein Data Bank archive (PDB) has served as the single repository of information about the 3D structures of proteins, nucleic acids, and complex assemblies.
The Worldwide PDB (wwPDB) organization manages the PDB archive and ensures that the PDB is freely and publicly available to the global community.
Thermofluor.org
- A resource for scientists using thermofluor to study protein stability and ligand binding
Crystalprotein.com
- 3D Protein Structures Lasered Into Glass
Luminorum
- Your structure laser etched into a beautiful crystal for dispaly piece
Belle Technology UK Ltd.
- Anaerobic & Dry Glove Box Systems
Coy Laboratory Products
- Glove boxes and anaerobic chambers
Plas Labs
- Acrylic containment and isolation technology
Heavy Atom Databank
- Information on the preparation and characterisation of HEAVY-ATOM derivatives of protein crystals
Preparing a Useful Derivative
- A collection of useful information by UCLA MBI
Earliest Solutions for Macromolecular Crystal Structures
- A supplement to History of Visualization of Biological Macromolecules
History of Visualization of Biological Macromolecules
- by Eric Martz and Eric Francoeur
Biochemistry
- Biochemistry provides an international forum for publishing exceptional, rigorous, high-impact research across all of biological chemistry.
Bioorganic & Medicinal Chemistry
- The Tetrahedron Journal for Research at the Interface of Chemistry and Biology
Current Opinion in Structural Biology
- Current Opinion in Structural Biology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas.
EMBO Journal
- The EMBO Journal publishes papers describing original research of broad general interest in molecular and cell biology - a particular emphasis is placed on molecular mechanism and physiological relevance.
FASEB Journal
- The FASEB Journal publishes international, transdisciplinary research covering all fields of biology at every level of organization: atomic, molecular, cell, tissue, organ, organismic and population.
Journal of Applied Crystallography
- Many research topics in condensed matter research, materials science and the life sciences make use of crystallographic methods to study crystalline and non-crystalline matter with neutrons, X-rays and electrons.
Journal of Biological Chemistry
- The Journal of Biological Chemistry welcomes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes.
Journal of Synchrotron Radiation
- Synchrotron radiation research is rapidly expanding with many new sources of radiation being created globally.
Nature
- The Nature Research portfolio includes journals, online databases, and services across the life, physical, chemical and applied sciences and clinical medicine.
PNAS
- Proceedings of the National Academy of Sciences for the United States of America.
Protein Science
- Protein Science, the flagship journal of The Protein Society, serves an international forum for publishing original reports on all scientific aspects of protein molecules.
Science
- Science has been at the center of important scientific discovery since its founding in 1880—with seed money from Thomas Edison.
Structure
- Structure focuses on structural biology, studies of macromolecular structure and related issues.
Wyatt Technology
- DynaPro (Protein Solutions) Titan & Plate Reader
Malvern Instruments
- Zetasizer Nano for Protein Crystallization
European XFEL
- European X-Ray Free-Electron Laser
FLASH
- Free-electron laser FLASH
SACLA
- SPring-8 Angstrom Compact free electron laser
SLAC LCLS
- Stanford Linear Accelerator Linac Coherent Light Source
SwissFEL
- Swiss Free Electron Laser
Membrane Proteins of Known Structure
- from the Stephen White laboratory at UC Irvine
Membrane Protein Video Tutorial 1 by Martin Caffrey
- Use of a Robot for High-throughput Crystallization of Membrane Proteins in Lipidic Mesophases
Membrane Protein Video Tutorial 2 by Martin Caffrey
- Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases
Membrane Protein Video Tutorial 3 by Martin Caffrey
- Harvesting and Cryo-cooling Crystals of Membrane Proteins Grown in Lipidic Mesophases for Structure Determination by Macromolecular Crystallography
PDBTM
- Protein Data Bank of Transmembrane Proteins
ARI - Art Robbins Instruments
- CrysCam
CRAIC Technologies
- CRAIC Technologies Protein Crystal Imaging & Spectroscopy
Formulatrix
- ROCK IMAGER - Crystallization Imagers
Jan Scientific
- UVEX crystal imaging systems.
Korima
- Protein Review Station - UV and Visible
Motic
- More than microscopy. Microscopes & cameras & accessories.
Mounting crystals in quartz or glass capillaries
- Duilio Cascio UCLA
fDETECT - fast Determination of Eligibility of TargEts for CrysTallization
- fDETECT is a webserver that predicts propensity of protein sequences for completion of material production, purification, crystallization and diffraction-quality crystallization. This webserver implements the fDETECT method - (fast Determination of Eligibility of TargEts for CrysTallization). fDETECT takes less than one second per protein to complete the prediction.
PPCpred - predictor of protein Production, Purification and Crystallization
- The server is designed for sequence-based prediction of protein crystallization, purification, and production propensity.
Prediction of Protein Crystallizability
- XtalPred crystallizability classification is based on statistics on non-secreted wild-type microbial proteins and is optimized for identifying the most promising crystallization targets from large protein families. XtalPred is also helpful in construct design, although crystalizability class itself is usually not a sufficient criterion to find precise construct boundaries.
Alphalyse
- Alphalyse is a specialized contract research organization (CRO) providing high-quality protein analysis service to support the research, manufacturing and clinical development of natural and ...
Applied Biomics
- Applied Biomics is committed to providing the top-quality, full line services in proteomics
Cayman Chemical
- Backed by years of experience and expertise, Cayman offers comprehensive recombinant protein production services that include multiple expression platforms, purification methods, and characterization services to meet your project’s specific needs. This complements a catalog of hundreds of recombinant proteins and antibodies. As a Cayman client, you remain in control of your project while we provide a flexible, phase-based approach to help achieve your project goals.
Cayman’s scientists will ensure that your protein is engineered to exact specifications and produced using the optimal bacterial, insect, or mammalian expression system. Choose from a selection of expression-ready constructs or have our team develop one specific to your project.
Cube Biotech
- Services and products for protein expression, purification, and stabilization. Membrane protein sample preparation for ligand screening and diagnostic assays, cryo electron microscopy, antibody generation, and crystallization.
Proteos
- Specialists in protein production, expression and purification
Check My Blob
- CheckMyBlob is a machine learning system that automatically detects and validates ligands in X-ray electron density maps. Upload your files or type a PDB code to try it out!
CrysPred predictor
- Prediction of crystallization probability based on pI
CRYSTALP2
- Method for in-silico prediction of protein crystallization propensity
ExPASy Proteomics tools
- Protein identification and characterization and more...
Make Tray
- Create crystallization experiments, worksheets and documentation
MoonProt - A Database for Moonlighting Proteins
- This database provides a centralized, web-based location to organize information about moonlighting proteins for which there is biochemical and/or biophysical evidence of both functions being performed by the same protein.
MoRDa
- Automatic Molecular Replacement Pipeline
PSIPRED Protein Sequence Analysis Workbench
- The PSIPRED Protein Sequence Analysis Workbench aggregates several UCL structure prediction methods into one location. Users can submit a protein sequence, perform the predictions of their choice and receive the results of the prediction via e-mail or the web.
ProteinsPlus
- The openly accessible ProteinsPlus web server at https://proteins.plus is a unique resource enabling protein structure mining and modeling, focussing on protein-ligand interactions.
Proteopedia
- The collaborative, 3D encyclopedia of proteins and other molecules.
REFOLDdb
- REFOLDdb is a tool for the optimization of protein refolding, referring to published methods employed in the refolding of recombinant proteins.
Required crystal number or size calculator
- Feasibility of MAD experiments
SER: Surface Energy Reduction Prediction Server
- The aim of this tool is to suggest mutation candidates that are likely to enhance a protein's crystallizability via the generation of crystal contacts by the Surface Entropy Reduction (SER) approach described by Derewenda (2004).
BioOrbit
- Bringing the hospital to home via space. Turning hospital treatments into at-home injectables through crystallising drugs in space.
Redwire
- Redwire offers technology designed to offer pharmaceutical companies and researchers novel and flexible services to leverage the microgravity environment to grow small-batch crystals of protein-based pharmaceuticals and other key pharmaceutically relevant molecules. Understanding crystal growth and design can inform the entire drug discovery and development and design process for small molecule and large biomolecule pharmaceuticals as companies look to deliver new, optimized treatments to help patients.
Serendipity Space
- Transforming pharmaceuticals with Zero-G precision. Serendipity Space processes pharmaceutical compounds in space and brings them back to Earth. Microgravity enables high quality processing and entirely new forms of pharmaceutical compounds. We are building reusable satellites with re-entry capability, that can bring payloads back from space to earth. Serendipity Space aims to produce materials and products of superior quality compared to the ones on Earth, using the microgravity assist, kickstarting the industrialization of LEO.
Space CliniTech
- Space LiinTech provides microgravity-enabled modular experiment systems for biopharma R&D in space, including the ISS. We develop standardized and customizable payloads compatible with the ISS EXPRESS Rack, enabling reliable power, control, and data capabilities for your experiments. In parallel, we design and validate CubeSat platforms in LEO to expand scalable in-orbit biopharma research.
We support the full mission lifecycle, including payload integration, safety and ISS compatibility processes, mission operations, data delivery, and post-mission analysis.
Our core business in space medicine includes:
Protein crystallization and structural biology
Formulation studies, cell-based assays, and process validation
In-orbit technology demonstration (IOD/IOV) and translational research
By integrating biotechnology and space science, Space LiinTech advances space biopharma research and strengthens Korea’s scientific and industrial competitiveness in the era of low Earth orbit commercialization.
Varda Space Industries
- Varda is a microgravity-enabled life sciences company that processes materials in orbit and returns them to Earth. Discover unique morphologies and crystal structures in microgravity. Varda’s Reduced convection and sedimentation allows for particle size tuning and can result in the formation of large and ordered crystals for high-resolution X-ray structural determination or small and uniform particles to improve drug delivery. microgravity platform provides a unique path to formulating small molecules and biologics to improve shelf-life, bioavailability, and the patient experience. The unique environment of microgravity allows for the generation of enabling product and process IP for new chemical entities (NCEs) as well as life cycle management of marketed drugs.
Robotic Sample Handling Systems - Compatibility
- Beamline, sample mounting system, container and pins compatibility
CAMD - Center for Advanced Microstructures and Devices
- BBaton Rouge, Louisiana, USA
Synchrotrons
- Mail-in service or remote access
ALS - Advanced Light Source
- Berkeley, California, USA
ANKA
- Test Facility and Synchrotron Radiation Source at KIT
Australian Synchrotron
- Melbourne, Australia
BESSY II
- Berlin, Germany
BSRF - Beijing Synchrotron Radtiation Facility
- Beijing, P.R. China
Brookhaven National Laboratory
- Macromolecular Crystallography
CHESS - Cornell High Energy Synchrotron Source
- Ithaca, New York, USA
CLS - Canadian Light Source
- Saskatoon, Saskatchewan, Canada
Berkeley Center for Structural Biology
- Lawrence Berkeley National Lab - Berkeley Center for Structural Biology
DELTA
- Dortmund, Germany
Diamond Light Source
- Didcot, United Kingdom
ELETTRA
- Trieste Italy
ELSA
- Bonn, Germany
SSRL - Stanford Synchrotron Radiation Laboratory
- Stanford, California, USA
ESRF - European Synchrotron Radiation Facility
- Grenoble, France
DESY Photon Science
- Hamburg, Germany
INDUS 2
- Raja Ramanna Centre for Advanced Technology
APS - Advanced Photon Source
- Argonne, Illinois, USA
LNLS - aboratrio Nacional de Luz Sncrotron
- Campinas, Brazil
MAX IV
- Lund, Sweden
NE-CAT
- Northeastern Collaborative Access Team
NSLS-II- National Synchrotron Light Source II
- Upton, New York, USA
Photon Factory
- Tsukuba, Ibaraki, Japan
Pohang Accelerator Laboratory
- Pohang, Kyungbuk, Korea
SOLEIL
- GIF-sur-YVETTE, France
SER-CAT
- Southeast Regional Collaborative Access Team
SLS - Swiss Light Source (Paul Scherrer Institut)
- Villigen, Switzerland
Spring-8 - Japan Synchrotron Radiation Research Institute
- Hyogo, Japan
SSRF
- Shanghai Synchrotron Radiation Facility
ALBA Synchrotron Light Facility
- Barcelona, Spain
Lightsources.org
- Lightsources.org is the result of a collaboration between communicators from light source facilities around the world. This platform groups 23 synchrotrons and 6 FEL facilities representing 24 organisations from 3 geographic zones: Europe / the Middle East, the Americas, and Asia / Australia.
This site is a global resource, providing information and updates about light sources research and achievements, and opportunities for careers and international collaboration. This is made possible by financial support from the member facilities, whose contributions enable further promotion and international coverage of their innovations and capabilities.
Flash Cooling of Crystal in Bulk Liquid Nitrogen Cryo Vial Tutorial
- This video shows the flash cooling of a protein crystal in bulk liquid nitrogen and transfering the crystal in a cryoloop into a cryo vial.
Protein Crystallography - SPring 8
- Overview of crystallography at SPring 8 from expression to structure
Hanging Drop Vapor Diffusion
- Hampton Research
Sitting Drop Vapor Diffusion Crystallization
- Hampton Research
Setting crystallization trays
- Janet Smith Lab
How to mount protein crystals using cryotongs
- Video instruction of how to flash cool a crystal in liquid nitrogen and then mount using cryotongs on an X-ray diffractometer.
Freezing crystals
- Janet Smith Lab
How do they grow and analyse protein crystals?
- Backstage Science
Time lapsed protein crystal growth
- Lysozyme
Rigaku
- X-Ray Diffraction, Cryogenic Systems, Contract Services
Bruker-Axs
- Bruker Advanced X-ray Systems
Mar USA (Rayonix)
- X-ray Instruments fro Crystallography & Diffraction
Tools of the Trade
- A short list of tools used in crystallographic and X-ray diffraction experiments. Point to image for link to supplier.
Memmert
- Peltier-Cooled Incubators IPP
Powers Scientific, Inc.
- Protein Crystal Growth Chambers (temperature incubators)
Revolutionary Science
- Incufridge - Chilling Incubators / Refrigerator Incubators
Torrey Pines Scientific
- ECHOtherm Chilling/HEating Incubators 4-70 degrees Celsius