Job Description
Embedded within the Broad Institute, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional “drug hunters”. Our mission is to translate cutting edge biological insights originating from the Broad community into impactful drug discovery projects. In executing this mission we bring together faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry partners in venture capital, biotechnology, and pharmaceutical companies.

We combine our deep expertise in drug discovery with the knowledge and unique capabilities of the Broad Institute to address a wide range of disease areas including oncology, cardiovascular disease and diabetes, psychiatric disease, infectious disease, and rare diseases. Our goal is to embrace Broad's culture of creativity and open sharing to de-risk therapeutic hypotheses, validate new targets, and advance new therapies that will improve human health globally.

OVERALL RESPONSIBILITY
The Broad Institute is in search of a highly motivated and capable Research Scientist to join the Center for the Development of Therapeutics (CDoT). CDoT is committed to developing and applying novel drug discovery approaches and technologies to address critical unmet medical needs not being tackled elsewhere. The successful candidate will share this commitment and be part of a multidisciplinary team that drives innovation to solve therapeutic challenges.

The primary role of this position is to provide structural biology support for various drug discovery projects. The successful candidate will have significant interest and experience in the crystallization of proteins and protein-ligand complexes for the purpose of X-ray diffraction and subsequent structure elucidation. Importantly, given our multidisciplinary project team approach to drug discovery, the successful candidate will also need to thrive in a collaborative team environment.

ROLE-SPECIFIC RESPONSIBILITIES
Crystallize protein targets alone and in complex with ligands:
          •Screen for, and identify protein crystallization conditions
          •Optimize crystallization and diffraction of hits
          •Employ automated technologies to achieve the above (Mosquito, Rockmaker/RockImagers, Formulator)
Devise and implement robust protocols for the routine soaking or co-crystallization of ligands
Prepare and freeze protein crystals for shipping and remote data collection
Work collaboratively with colleagues in protein sciences, biophysics, computational chemistry, medicinal chemistry, and other disciplines in support of structure-based drug design

GENERAL RESPONSIBILITIES
In the day-to-day execution of his/her science, it is expected that the successful candidate will:
Initiate and complete routine procedures independently and efficiently
Interpret experimental outcomes and proposing next steps
Troubleshoot technical and scientific problems
Operate and maintain laboratory equipment independently
Document work and effectively present results

QUALIFICATIONS
Core qualifications:
       •Masters or PhD in Structural Biology, Biophysics, Biochemistry or a related life science field with 0 - 2 years of post-degree research experience in an industrial or academic setting
          •Hands-on experience crystallizing protein targets
          •A proven record of successful interaction with project team members, external customers, or vendors
Advantageous experience:
          •Design and generation of recombinant protein expression constructs
          •Bacterial, insect, and/or mammalian recombinant protein expression
          •Protein purification through multiple techniques (affinity, ion exchange, size exclusion)
          •Biophysical and functional characterization of recombinant proteins
          •Structure solution (eg via molecular replacement), building, and refinement of crystallographic protein structures
          •Cryo-EM protein sample / grid preparation

The successful candidate will be a results-focused, team-oriented bench scientist able to excel across multiple projects in a dynamic fast-paced environment. S/he must be accountable, self-motivated, detail-oriented and exhibit problem solving skills. In addition, the successful candidate will be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with team members.

WORKING CONDITIONS
Normal laboratory conditions
Normal office conditions

The Broad Institute will not offer visa sponsorship for this opportunity.

All Broad employees, regardless of work location, must be fully vaccinated for COVID-19 by Tuesday, October 12, 2021. Requests for exemption for medical or sincerely held religious beliefs will be considered.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled

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All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled

About Us
The Broad Institute is pioneering a new model of collaborative biomedical science to transform biology and medicine. To do that, we have created a unique community of amazing, creative people — “Broadies” — each with a passion for pushing scientific frontiers.

Broadies have a diverse collection of talents, expertise, and backgrounds, creating a rich collaborative environment for solving intractable scientific problems. We are always looking for new team members within Research, Computational Biology, Software Engineering, and Administration to help us tackle important problems at the cutting edge of science.

Why Broad?
It comes down to our culture. Our community transcends academic and organizational barriers, encouraging different points of view and making all Broadies part of something meaningful.

If ours is a community you would want to be a part of, then please apply!

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