Research Assistant/Associate
Requisition ID: 17185
Location: Newcastle, GB
Contract Type: Fixed Term
Working Pattern: Full Time
Posted Date: 29-Mar-2022

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

We understand how important the full employment package is to our colleagues at Newcastle University and we are committed to providing a great range of benefits and discounts for all. You can learn more about what is available here on our Benefits Website page.

Starting Salary:
Research Assistant from £28,756 to £30,497 per annum
Research Associate from £31,406 to £33,309 per annum

Closing Date: 22 April 2022

The Role
Based in the Newcastle University Translational and Clinical Research Institute, a Research Associate/Assistant is required to work with Professor Martin Noble on a project that will focus on prosecuting a novel drug target for oncology treatment. A key element of the post will be to use contemporary structural, biochemical, and biophysical techniques in support of medicinal chemistry and target validation for drug discovery.

This is a significant opportunity for an experienced researcher with excellent protein chemistry, structural biology and in vitro biochemical and biophysical assay development and implementation skills. You will work within a large multi-disciplinary team that includes biologists and chemists.

You will work within the Newcastle Cancer Centre Drug Discovery Unit based in the Paul O’Gorman Building and will plan and organise your work under direct supervision from Professor Martin Noble.

The position is available from May 1st, 2022 until April 30th, 2024.

For informal enquiries regarding the role, please contact Professor Martin Noble via (

Information about the Drug Discovery Unit can be found at:

Information about the Faculty of Medical Sciences is available at:

As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

Key Accountabilities
•You will prepare and characterise recombinant protein and protein complexes and play a major role in experiments that address structure and function at the molecular level.
•Working within a team you will devise and implement appropriate biophysical assays in support of medicinal chemistry.
•You will carry out sample preparation and data collection for X-ray crystallography
•You will provide structural support and analysis of an existing drug discovery target for staff and students in the Drug •Discovery Group. You will enable the group to interpret and analyse research outputs from structural investigations and make recommendations for future research directions.
•You will perform statistical analyses for experimental readouts to produce robust and reproducible data.
•You will make a substantial contribution to planning and preparing scientific reports and publications.
•You will record and archive results with meticulous attention to detail and present results at internal and external meetings.
•You will assist in the supervision of undergraduate and postgraduate students in the laboratory.
•You will contribute to laboratory meetings e.g. problem solving, internal seminars, journal club.
•You will perform risk assessments and maintain safety laboratory records (e.g. COSHH) in consultation with academic staff.
•You will organise and assist in general laboratory duties e.g. stores, equipment maintenance, and general cleaning.
•You will maintain a high level of up-to-date specialist knowledge, by participating in relevant conferences, courses and through collaboration.

The Person (Essential)

Knowledge, Skills and Experience
•Expertise in contemporary molecular biology techniques.
•Expertise in recombinant expression of proteins in insect and bacterial cell culture.
•Expertise in biochemical and biophysical techniques for assessing protein-ligand interactions: Inventive assay design and implementation.
•Experience of high throughout crystallography in support of medicinal chemistry (protein crystallization, X-ray diffraction data collection and computational crystallography).
•Presentation of results at internal and external meetings, and assistance with writing publications.
•Assistance in the supervision of undergraduate and postgraduate students in the laboratory.
•Contributions to laboratory meetings e.g. problem solving, internal seminars, journal club.
•The performance of risk assessments and maintaining safety laboratory records, (e.g. COSHH) in consultation with academic staff.
•Organisation and assistance in general laboratory duties e.g. stores, equipment maintenance, and general cleaning.

Attributes and Behaviour
•Capacity for original thought.
•Enthusiastic, flexible and hard working with the ability to work to tight deadlines.
•Excellent oral communication and writing skills.
•The ability to work flexibly as part of a multi-disciplinary team.
•High level analytical skills and capacity for original thought.
•Commitment to continuing professional development.
•Good IT and computing skills.
•Ability to take an active role in determining the future directions of research project.

•Bachelor’s degree (or equivalent) in a relevant science subject – preferably biomedical.
•A PhD in the area of protein biochemistry, protein biophysics or X-ray crystallography (Required to be appointed at Research Associate level only)

Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains colleagues from all sectors of society. We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent. We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.

The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality. The University also holds the HR Excellence in Research award for our work to support the career development of our researchers, and is a member of the Euraxess initiative supporting researchers in Europe.
Requisition ID: 17185

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