Postdoctoral Scientist – Structural and Chemical Biology of E3 ligases
Centre for Medicines Discovery, University of Oxford, Old Road Campus Research Building, Headington, Oxford, OX3 7DQ

Grade 7: Salary in range £32,817 - £40,322 per annum

We are seeking a Postdoctoral Scientist – Structural and Chemical Biology of E3 ligases to join the “Growth Factor Signalling and Ubiquitination” Group at the University of Oxford for work on a new Innovative Medicines Initiative (IMI) funded project, “EUbOpen”, which aims to generate chemical inhibitors for E3 ubiquitin ligases and other druggable protein families.

Reporting to the Principal Investigator, Dr Alex Bullock, and working closely with other scientists within the group, you will contribute to the group effort to establish efficient expression, purification and crystallisation systems for novel human E3 ligase proteins. You will study the interaction of E3 substrate proteins, peptides and low molecular weight compounds and solve their structures with the goal to develop a highly selective chemical probe molecule. The project milestones are very ambitious and you will have to be a self-motivated, skilful scientist in order to make a strong contribution to the project.

It is essential that you have a PhD (or close to completion) in protein biochemistry/structural biology with an excellent academic record of accomplishment. You should have experience in protein purification, biophysical characterization of protein-ligand interactions (e.g. SPR), as well as crystallization and structure determination of proteins. Experience in ubiquitin biology and assay development would be beneficial.

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

This post is offered full-time on a fixed term contract until 30 April 2025, and is funded by the Innovative Medicines Initiative.

Please quote 153890 on all correspondence. Only applications received before 12.00 noon on Wednesday 10 November 2021 will be considered.

Contact Person : NDM Recruitment Team
Vacancy ID : 153890
Contact Phone : 01865287507
Closing Date & Time : 10-Nov-2021 12:00
Contact Email :

Click HERE for the original job details posting.

Nature Reviews Drug Discovery volume 18, pages 949–963 (2019)

Informal inquiries can be sent to