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Application Deadline : 30 June 2024 00:00:00 Paris time
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General information
Offer title : Biophysics researcher (M/F) (H/F)
Reference : UMR5075-VALLAN-024
Number of position : 1
Workplace : GRENOBLE
Date of publication : 15 May 2024
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 September 2024
Proportion of work : Full time
Remuneration : 2 905,76 €
Desired level of education : Niveau 8 - (Doctorat)
Experience required : 1 to 4 years
Section(s) CN : Molecular and structural biology, biochemistry

Missions
The researcher will develop an experimental approach for the determination of the photoinduced structural dynamics of photosensitive biomolecules in vivo using time-resolved X-ray scattering techniques.

Activities
- Optimizing biochemical protocols for protein overexpression
- Expressing and purify proteins
- Participating in time-resolved X-ray scattering experiments
- Analyzing and interpret experimental data
- Modeling experimental data using molecular dynamics simulations
- Presenting the results via reports and oral presentations in English
- Proposing development and improvement of experiments
- Writing protocols and research articles in English for the publication of the work carried out
- Participating in the life of the research group
- Supervising students
- Participating in the Institute's scientific events

Skills
- Skills in biophysics or soft matter physics
- Concepts of protein biochemistry (including protein expression and purification)
- Knowledge of tools for analyzing experimental data
- Knowledge of a programming language (Python, C++, etc.)
- English (written/oral) level B2
- Good autonomy
- Pro-activity in research, scientific curiosity
- Open-mindedness and listening
- Good interpersonal skills and ability to integrate and adapt to the group
- Communication skills (written and oral) and ability to report on your work

Work Context
Located in the Grenoble European Photon Neutron (EPN) Campus (ESRF/ILL/EMBL/IBS), the Institute of Structural Biology (IBS) is a national and international leading center in the field of integrated structural biology. At the same time as a research center, technical facility, reception and scientific training site, the IBS aims to develop structural biology science, a crucial field of research for understanding fundamental biological mechanisms. It contains 12 state-of-the-art facilities.
As a mixed research unit (CEA-CNRS-UGA) the IBS is composed of 21 research groups, each one offering a multi-disciplinary approach, at the frontiers of biology, physics and chemistry, in line with 3 axes of research. Nearly 300 people work there: researchers, doctoral students, engineers and technicians in a multicultural and international environment. The recruited person will join the Dynamop group which focuses on the study of the structural dynamics of biological macromolecules: https://www.ibs.fr/en/research/assembly-dynamics-and-reactivity/dynamics-and-kinetics-of-molecular-processes-group-m-weik/?lang=en .

Constraints and risks
Possibility, when carrying out experiments in facilities for the use of X-rays (even off-site), of working out of normal hours (weekends and/or nights). The research will be carried out either in French or English, however it is expected that the non-French speaking candidate will endeavor to learn the basics of French in order to facilitate communication and integration into the laboratory.

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