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Search our Tips from A to Z for more information. Still having trouble finding what you want? Contact Hampton Research technical support.
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| H is for Hollow Crystal |
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| The discovery of hollow crystals is common, particularly with hexagonal and trigonal crystals. The crystals grow rapidly and molecules add quickly at the rims but much more slowly at the center of the 001 face due to slower transport (diffusion / convection). An indentation forms which makes transport to the center of the face even harder. The center of the face begins to recede as the outside rims race ahead, a tunnel down the center forms, and the whole growth process snowballs. The center falls further and further behind as transport becomes slower and slower down the tunnel, the edges gallop ahead and you get a hollow crystal. |
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| H is for Hexanediol |
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| 1,6 Hexanediol (C6H14O2 Mr 118.18) is a non-volatile alcohol which most likely precipitates biological macromolecules by lowering the chemical activity of water. Non-volatile organics can be effective crystallization reagents for proteins and are particularly appropriate for nucleic acids. This non-volatile alcohol steals water molecules from the biological macromolecule through hydrogen bonding and reduces the electrostatic screening effectiveness of the water. Typical stock solutions of 6.0 M (about 71% w/v) are typical for this crystallization reagent. Typical reservoir concentrations for this reagent are 1 to 4 M across a broad pH range. 1,6 Hexanediol can be utilized in the presence of numerous anions and cations, as well as a broad range of salts. It can be a substitute crystallization reagent for MPD, PEG 400, and PEG MME 550. It can also be utilized as an additive in the concentration range of 0.1 to 0.2 M. 1,6 Hexanediol is a waxy solid or flake. When formulated with water, the reaction is endothermic and one might need to warm the solution to effect complete dissolution at high levels of supersaturation.
1,6 Hexanediol is utilized as a precipitant in Crystal Screen 2 and is available as a preformulated, sterile filtered reagent from Hampton Research (Catalog Number HR2-625; 6.0 M 1,6 Hexanediol, 200 ml). |
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