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Trimethylamine N-oxide dihydrate
Crystallization grade Trimethylamine N-oxide dihydrate for formulating screens or for optimization
Sterile filtered
Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (<1 Bacteria (CFU/ml)), pyrogen free (<0.03 Endotoxin (EU/ml)), RNase-free (< 0.01 ng/mL) and DNase-free (< 4 pg/µL)
0.05 to 1.0M TMAO may be used as a crystallizaton additive or in conjunction with PEG as a screen reagent
TMAO can manipulate sample sample interactions with the potential to minimize polydispersity and may also stabilize protein structure(4,5)
Trimethylamine N-oxide dihydrate
Synonym: TMANO
Mr 111.14
CAS Number [62637-93-8]
EC Number 214-675-6
Beilstein Registry Number 4(4)144
Merck 14,9711
RTECS YH2850000
MDL Number MFCD00002048
Purity >98.0%
Maximum solubility is 6.0 M at 25°C (tested by Hampton Research)

Measured pH Range: 8.0 - 9.3 at 25°C
Measured Conductivity Range: 14.7 - 67.1 µS/cm at 25°C
Measured Refractive Index Range: 1.34320 - 1.34344 at 20°C
HR2-777 Trimethylamine N-oxide dihydrate - 1.0 M solution 100 ml
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1.Use of organic cosmotropic solutes to crystallize flexible proteins: Application to T7 RNA polymerase and its complex with the inhibitor T7 lysozyme. Jeruzalmi and Steitz, J. Mol. Bio. (1997) 274, 748-756.
2.Trimethylamine N-oxide as a versatile cryoprotective agent in macromolecular crystallography. Mueller-Dieckmann, C., Kauffmann, B., and Weiss, M. J. Appl. Cryst. (2011). 44, 433–436.
3.Crystallization of a functionally intact Hsc70 chaperone. J. Jiang, E. M. Lafer and R. Sousa. Acta Cryst. (2006). F62, 39-43.
4.Doolittle, R. F. (2003). Biophys. Chem. 100, 307–313.
5.Hill, M. C., Bates, I. R., White, G. F., Hallett, F. R. & Harauz, G. (2002). J.
6.Auton, M. & Bolen, D. W. (2005). Proc. Natl Acad. Sci. USA, 102, 15065–15068.
7.Bolen, D. W. (2004). Methods, 34, 312–322.
SDS for HR2-777
Certificates of Analysis
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