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TMAO
TMAO

TMAO
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Applications
Water soluble cryoprotectant
Features
A very versatile cryoprotectant for macromolecular crystals
Protein stabilizer
TMAO can be a viable alternative when conventional cryoprotectants fail
Low viscosity and low surface tension
Sterile filtered
Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (<1 Bacteria (CFU/ml)), pyrogen free (<0.03 Endotoxin (EU/ml)), RNase-free (< 0.01 ng/mL) and DNase-free (< 4 pg/µL)
Methodologies
Try soaking the crystals in 4.0 M TMAO for 10 seconds and then cool directly in the cryo stream
Description
Trimethylamine N-oxide dihydrate (TMAO)
Formulated from TMAO dihydrate in Type 1 lab water (deionized) and sterile filtered (0.22 micron)
Synonyms: TMANO, TMAO
(CH3)3NO•2H2O
C3H9NO•2H2O
Mr 111.14
CAS Number [62637-93-8]
EC Number 214-675-6
Beilstein Registry Number 4(4)144
Merck 14,9711
RTECS YH2850000
Purity ≥ 98.0%

Measured pH range: 9.2 - 10.6 at 25°C
Measured Conductivity Range: 8.6 - 96.6 µS/cm at 25°C
Measured Refractive Index Range: 1.37660 - 1.37793 at 20°C

When using TMAO as a cryoprotectant, try soaking the crystals in 4.0 M TMAO for 10 seconds and then cryo cool directly in the cryo stream.
CAT NO NAME DESCRIPTION
HR2-857 4.0 M TMAO 1 ml
Price Quantity
$22.50
References
1.Trimethylamine N-oxide as a versatile cryoprotective agent in macromolecular crystallography. Christoph Mueller-Dieckmann, Brice Kauffmann and Manfred S. Weiss. J. Appl. Cryst. (2011). 44, 433–436 doi:10.1107/S0021889811000045
SUPPORT MATERIALS
HR2-857 SDS
Certificates of Analysis
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