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Paratone-N
Paratone-N
Paratone-N


Applications
Cryoprotectant
Description
Paratone-N is a viscous cryoprotectant for both small and large molecule crystallography.1 Mildly air-unstable, small molecule compounds can be coated with Paratone-N under an inert atmosphere. The Paratone-N protected crystal sample can be cryocooled in a chilled nitrogen gas stream. Paratone-N has also been used successfully as a cryoprotectant for biological macromolecule crystals. Used during cryocrystallography to displace and reduce the amount of water (mother liquor, reagent) on the crystal after the crystal is mounted in a cryoloop. Coating the crystal with Paratone can minimize evaporation from the crystal and reduce exposure and slow diffusion of air (oxygen) to the crystal.

The viscosity of Paratone-N can be reduced to improve handling with fragile needle and blade crystals by mixing 50:50 with Paraffin Oil.

Paratone-N is also known as Parabar 10312, Paratone 8277, and Infineum V8512.

Paratone-N is a blend of polyisobutylenes with a Staudinger molecular weight of about 20,000 and contains about 20% polymer.

Refractive index 1.48487 at 20 degrees Celsius.
ITEMS
CAT NO NAME DESCRIPTION
HR2-643 Paratone-N 100 ml bottle, each
Price Quantity
$55.00
References
1.H. Hope, Cryocrystallography of biological macromolecules: a generally applicable method. Acta Cryst. (1988) B44, 22-26.
2.Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226. F. Wang, X.- Liu, H. Li, K.- Liang, J. N. Miner, M. Hong, E. A. Kallel, A. van Oeveren, L. Zhi and T. Jiang. Acta Cryst. (2006). F62, 1067-1071
3.H. Hope, Annu. Rev. Biophys. Chem. 1990 19:107-126
4.S. Parkin and H. Hope, J. Appl. Cryst. (1998) pages 945-953
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