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Additive Screen • Additive Screen HT
Additive Screen • Additive Screen HT
Additive Screen • Additive Screen HT

Additive Screen • Additive Screen HT
Crystal of bacterial di-haem Cyt c4 grown using the Hampton Research Additive Screen. Ivana Tomcova, Institute of Physical Biology, Academy of Science of the Czech Republic.
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Applications
Manipulate sample-sample & sample-solvent interactions to improve crystals or alter sample solubility
Features
18 classes of reagents
Highly concentrated (10x) reagent formulation
96 unique reagents
Tube or Deep Well block format
Crystallization or sample solubility optimization
Description
Additive Screen is a library of small molecules that can affect the solubility and crystallization of biological macromolecules, including both soluble and membrane proteins. These small molecules can perturb and manipulate sample-sample and sample-solvent interactions, as well as perturb water structure which can alter and improve both the solubility and crystallization of a sample. Additives can stabilize or engender conformity by specific interaction with the macromolecules. There are numerous reports of the use of additives to improve the quality and size of macromolecular crystals.1-5

Additive Screen contains 96 unique reagents, 1 ml each.

Additive Screen HT contains 96 unique reagents, 1 ml each, in a single Deep Well block.
ITEMS
CAT NO NAME DESCRIPTION
HR2-428 Additive Screen 1 ml, tube format
Price Quantity
$490.00
CAT NO NAME DESCRIPTION
HR2-138 Additive Screen HT 1 ml, Deep Well block format
Price Quantity
$490.00
References
1.Crystallization of membrane proteins., Edited by Hartmut Michel, CRC Press (1991).
2.Crystallization of Nucleic Acids and Proteins: A Practical Approach., Edited by A. Ducruix and R. Giege, Oxford University Press (1992).
3.Cudney, R., et al., Screening and optimization strategies for macromolecular crystal growth., Acta Cryst. (1994) D50, 414-423.
4.Sousa R., Use of glycerol, polyols and other protein structure stabilizing agents in protein crystallization., Acta Cryst. (1995) D51, 271-277.
5.Trakhanov, S. and Quiocho, F.A., Influence of divalent cations on protein crystallization., Protein Science (1995) 4, 9, 1914-1919.
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