| Associations Related to Crystallography |
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|  | Instruct - Integrated structural biology unlocking the secrets of life |
| | ACA - American Crystallographic Association |
| | BCA - British Crystallographic Association |
| | Crystallography World Wide |
| | European Crystallographic Association |
| | IOBCr - International Organization for Biological Crystallization |
| | IUCr - International Union of Crystallography |
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| Automation for Crystallization |
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| | Art Robbins Instruments - Phoenix Liquid Handling System & Intelliplate |
| | Brandel - Automated plate sealer |
| | Douglas Instruments - Automatic Protein Crystallization Systems |
| | Digilab - Honeybee Systems for Protein Crystallization |
| | Fluidigm - Fluidigm – TOPAZ® system for High Throughput Crystallization |
| | Formulatrix - Protein crystallization automation solutions |
| | Hamilton Company - Hamilton robotics |
| | Innovadyne - Screenmaker/Platemaker for protein crystallization |
| | Rigaku - CrystalMation for Protein Crystallization and Imaging |
| | TriTek - CrystalPro & CrystalLIMS Protein Crystal Imaging |
| | Tecan - Freedom EVO® Protein Crystallography |
| | TTP Labtech - Mosquito nanoliter liquid handling for crystallization |
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| Bar Code Readers |
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| | Brady - Product identification solutions (Bar code readers) |
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| Cryogenic |
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| | High Pressure Cryo-Cooler for X-Ray Crystallography - Based on a process developed by Cornell University scientists Prof. Sol M. Gruner and Dr. Chae Un Kim |
| | Chart Biomed (MVE Vapor Shippers) - MVE model SC 4/2V single unit is popular at synchrotrons |
| | Oxford Cryosystems - Cryostream low temperature device. |
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| Crystallization and Crystallography Services |
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| | Bio-Xtal - Bio-Xtal is a proteomics service company operating since 1998 |
| | Carna Biosciences - Customized crystallization service |
| | Hauptman-Woodward Medical Research Institute - Crystallization services |
| | Paladin Scientific - Putting the Power of Macromolecular Crystallography to Work for You |
| | Proxychem - Provider of drug discovery solutions to the pharmaceutical and biotech communities |
| | NovAliX - Your partner for structure-based drug discovery |
| | SARomics Biostructures - Outsourcing Services: Drug Discovery and Structural Biology Platform |
| | Zenobia Therapeutics - Zenobia Therapeutics is dedicated to finding cures for unmet medical needs |
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| Crystallization Tutorials & Resources |
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| | BR's Macromolecular Crystallography Website - By Bernhard Rupp |
| | Hill Lab Crystallography Tutorials - University of Utah |
| | Protein Crystallization Tutorial - By Terese Bergfors |
| | Protein Crystallography Course (Structural Medicine) - University of Cambridge |
| | PX Universe - By The Life Science Group At Rigaku |
| | X-Tal Protocols - By Johan Zeelan |
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| Databases |
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| | Binding Database - Measured binding affinities for biomolecules, genetically or chemically modified biomolecules, and synthetic compounds. |
| | BMCD - Biological Macromolecular Crystallization Database |
| | BRENDA - The Comprehensive Enzyme Database |
| | Disprot - Database of Protein Disorder |
| | ExPASy Proteomics Tools - The ExPASy (Expert Protein Analysis System) proteomics server of the Swiss Institute of Bioinformatics (SIB) is dedicated to the analysis of protein sequences and structures as well as 2-D PAGE. |
| | Heavy Atom Databank |
| | HIC-Up Hetero Compound Binding Database - Hetero-compound (small molecule) Information Centre |
| | JAXA Cryoprotectant database for protein crystals - Cryoprotectant database for protein crystals |
| | LipidBank - he official database of Japanese Conference on the Biochemistry of Lipids (JCBL) |
| | Marseille Protein Crystallization Database (MPCD) - Crystallization database populated from the BMCD and CYCLOP |
| | Membrane Proteins of Known Structure - Fom the Stephen White laboratory at UC Irvine |
| | Membrane Protein Data Bank (MPDB) - An on-line, searchable, relational database with select structural and functional information on membrane proteins and peptides |
| | Metalloprotein Database & Browser |
| | Nucleic Acid Database Project |
| | PDB - Protein Data Bank |
| | PDB Ligand Expo Search - Chemical component search tools |
| | PepcDB - Protein expression purification and crystallization DataBase |
| | PICKScreens Database - The PICKScreens database is a Microsoft Office Access Database for the comparison of crystallization screen formulations |
| | PSdb - Protein Structure Database |
| | PubChem - PubChem provides information on the biological activities of small molecules. |
| | RCSB PDB Structural Genomics Information Portal - An Information Portal to Biological Macromolecular Structures |
| | Refold - This website contains entries for refolding protocols for a wide range of proteins |
| | Scratch Protein Predictor - Scratch Protein Predictor |
| | Structural Biology Software Database |
| | TargetDB - Target Search for Structural Genomics |
| | XtalBase - A crystallization and crystallography data management program |
| | Xtaldb - The Xtaldb crystallization expert system |
| | XTALpIms - xtalPiMS is part of the Protein Information Management System (PiMS) which covers crystallization |
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| Differential Scanning Fluorimetry / Thermofuor |
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| | Applied Biosystems® Protein Thermal Shift™ - Protein Thermal Shift Software & Reagents |
| | Thermofluor.org - A resource for scientists using thermofluor to study protein stability and ligand binding |
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| Forums for Crystallization & Crystallography |
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| | x-rayman.co.uk - A forum for discussing X-ray & Neutron diffraction, imaging, crystallography, hardware, software and any other X-ray & Neutron techniques |
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| Gift Ideas Related to Crystallography |
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| | Crystalprotein.com - 3D Protein Structures Lasered Into Glass |
| | Luminorum - Your structure laser etched into a beautiful crystal for dispaly piece |
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| Glove Boxes / Anaerobic Chambers |
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| | Coy Laboratory Products - Glove boxes and anaerobic chambers |
| | Plas Labs - Acrylic containment and isolation technology |
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| Heavy Atoms |
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| | HATODAS - Heavy-atom Database System |
| | Heavy Atom Databank - Information on the preparation and characterisation of HEAVY-ATOM derivatives of protein crystals |
| | Heavy Atom Screens - Available from Hampton Research |
| | Preparing a Useful Derivative - A collection of useful information by UCLA MBI |
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| History of Crystallization & Crystallography |
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| | Earliest Solutions for Macromolecular Crystal Structures - A supplement to History of Visualization of Biological Macromolecules |
| | History of Visualization of Biological Macromolecules - by Eric Martz and Eric Francoeur |
| | Conquering the realm invisible - How X--ray crystallography reveals hidden structures |
| | Turd of the century - An exhibition celebrating one of the greatest scientific advances of the 20th century has an unexpected centrepiece |
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| Journals |
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| | Acta Crystallographica Section D: Biological Crystallography |
| | Acta Crystallographica Section F Structural Biology and Crystallization Communications |
| | Biochemistry |
| | Bioorganic & Medicinal Chemistry |
| | Current Opinion in Structural Biology |
| | EMBO Journal |
| | FASEB Journal |
| | Journal of Applied Crystallography |
| | Journal of Biological Chemistry |
| | Journal of Biomolecular Structure & Dynamics |
| | Journal of Synchrotron Radiation |
| | Nature |
| | PNAS |
| | Protein Science |
| | Science |
| | Structure |
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| Lab Protocols |
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| | Thermofluor - Assay for protein stability |
| | Protein Crystallization & Heavy Atom Screening - Structural Molecular Biology Laboratory at UCLA - Duilio Cascio & Michael R. Sawaya |
| | Protein Crystallography Course - The Macromolecular Crystallography course was presented in the 1999-2000 academic year to staff and students of CIMR, University of Cambridge and the MRC-LMB. |
| | Xtals.org - Crystallization Related Methods and More from Artem Evdokimov |
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| Light Scattering |
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| | Norton Scientific - PAM ZERO |
| | Avid Nano - Advancing dynamic light scattering |
| | Malvern Instruments - Zetasizer Nano for Protein Crystallization |
| | Wyatt Technology - DynaPro (Protein Solutions) Titan & Plate Reader |
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| Membrane Proteins |
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| | Membrane Protein Video Tutorial 1 by Martin Caffrey - Use of a Robot for High-throughput Crystallization of Membrane Proteins in Lipidic Mesophases |
| | Membrane Protein Video Tutorial 2 by Martin Caffrey - Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases |
| | Membrane Protein Video Tutorial 3 by Martin Caffrey - Harvesting and Cryo-cooling Crystals of Membrane Proteins Grown in Lipidic Mesophases for Structure Determination by Macromolecular Crystallography |
| | Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases - Martin Caffrey, Christopher Porter |
| | Art Robbins Instruments - Gryphon LCP |
| | Formulatrix - NT8-LCP |
| | Gilson - Flexus Crystal IMP |
| | TTP Mosquito - Lipid Cubic Phase (LCP) Screening |
| | Zinsser NA ProCrys Meso - Automated Protein Crystallization of Membrane Proteins |
| | CGBD - A Database of Inserted Membrane Proteins |
| | European Membrane Protein Consortium - The E-MeP consortium is focused on solving the structures of membrane proteins. |
| | Membrane Protein Databank - Martin Caffrey's Membrane Protein Data Bank (University of Limerick) |
| | Membrane Proteins of Known 3D Structure - From the Stephen White laboratory at UC Irvine |
| | PDBTM - Protein Data Bank of Transmembrane Proteins |
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| Microscopes & Imaging for Crystals |
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| | CRAIC Technologies - CRAIC Technologies Protein Crystal Imaging & Spectroscopy |
| | CrysCam - An affordable high-resolution digital microscope camera |
| | Diagnostic Instruments - Digital CCD Cameras for Microscopy and Scientific Imaging |
| | Explora Nova - Xtal Focus - Crystal Imaging |
| | Fluidigm - Fluidigm – AutoInspeX® workstation – Unparalleled Crystal Imaging and Automated Scoring |
| | Hirox - FMP Products, Inc. - 3D Digital Video Microscope for Crystallization |
| | JAN Scientific - UVEX UV microscope for protein crystal inspection |
| | Korima - Protein Review Station - UV and Visible |
| | Nexus Biosystems - Crystal Farm |
| | Rigaku Automation - Minstrel & Desktop Minstrel |
| | TriTek Corp. - CrystalPro - Protein Crystal Imaging |
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| Newsgroups |
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| | x-rayman.co.uk - A forum for discussing X-ray & Neutron diffraction, imaging, crystallography, hardware, software and any other X-ray & Neutron techniques |
| | Automatic Protein Crystallization & Microbatch Newsgroup - General tips and techniques for protein crystallization, and also a forum for users of the Oryx and IMPAX robotic systems. |
| | CCP4 Bulletin Board Index - Index of CCP4 Bulletin Board Posts |
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| Protein Expression and Purification |
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| | Alphalyse - Alphalyse is a specialized contract research organization (CRO) providing high-quality protein analysis service to support the research, manufacturing and clinical development of natural and ... |
| | Applied Biomics - Applied Biomics is committed to providing the top-quality, full line services in proteomics |
| | Proteos - Specialists in protein production, expression and purification |
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| Software & Web Based Tools |
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| | CrysPred predictor - Prediction of crystallization probability based on pI |
| | Crystal Screen Wizard - X-ray crystallography tools to help you collate and analyze your protein and DNA crystal screening trials |
| | CRYSTALP2 - Method for in-silico prediction of protein crystallization propensity |
| | DISOPRED2 Disorder Prediction Server - Check for disorder in your protein |
| | ExPASy Proteomics tools - Protein identification and characterization and more... |
| | MakeTray - Create crystallization experiments, worksheets and documentation |
| | MEMEX EXPROPRIATOR - A MEMbrane protein EXperimentability predictor |
| | Merohedral Crystal Twinning Server - Online test for determining any twinning in protein crystals |
| | PDB Sequence Search Tool - Sequence retrieval, amino acid composition, molecular weight, volume, pI, identical pattern matching and more. |
| | PROSO EXPROPRIATOR - A sequence-based PROtein SOlubility evaluator |
| | Protein Property Calculator - pI Calculator |
| | Proteopedia - The collaborative, 3D encyclopedia of proteins and other molecules. |
| | REFOLD - This website contains entries for refolding protocols for a wide range of proteins. |
| | SECRET EXPROPRIATOR - A SEquence-based CRystallizability EvaluaTor |
| | SER: Surface Energy Reduction Prediction Server - This exploratory tool aims to aid identification of sites that are most suitable for mutation designed to enhance crystallizability by a Surface Entropy Reduction approach. |
| | XtalBase - A crystallization management program |
| | XtalPred - XtalPred Server: Prediction of Protein Crystallizability |
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| Synchrotron Locations |
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| | Synchrotrons - Mail-in service or remote access |
| | ALS - Advanced Light Source - Berkeley, California, USA |
| | ANKA - Karlsruhe, Germany |
| | APS - Advanced Photon Source - Argonne, Illinois, USA |
| | Australian Synchrotron - Melbourne, Australia |
| | BESSY - Berlin, Germany |
| | BSRF - Beijing Synchrotron Radtiation Facility - Beijing, P.R. China |
| | CAMD - Center for Advanced Microstructures and Devices - BBaton Rouge, Louisiana, USA |
| | CHESS - Cornell High Energy Synchrotron Source - Ithaca, New York, USA |
| | CLS - Canadian Light Source - Saskatoon, Saskatchewan, Canada |
| | Collaborative Crystallography - Lawrence Berkeley National Lab - Berkeley Center for Structural Biology |
| | DELTA - Dortmund, Germany |
| | DFEL - Durham, North Carolina, USA |
| | Diamond - Didcot, United Kingdom |
| | ELETTRA - Trieste Italy |
| | ELSA - Bonn, Germany |
| | ESRF - European Synchrotron Radiation Facility - Grenoble, France |
| | ESRF Humdity Control Device (HC1) - The controlled (or uncontrolled) dehydration of protein crystals has been shown to improve the diffraction qualities of many proteins. |
| | HASYLAB - Hamburger Synchrotronstrahlungslabor - Hamburg, Germany |
| | INDUS 1 and 2 - Indore, India |
| | LNLS - aboratório Nacional de Luz Síncrotron - Campinas, Brazil |
| | LURE - Orsay, France |
| | MAX-Lab Lund University - Lund, Sweden |
| | NE-CAT - Northeastern Collaborative Access Team |
| | NSLS - National Synchrotron Light Source - Upton, New York, USA |
| | NSRRC - National Synchrotron Radiation Research Center - Hsinchu, Taiwan, Republic Of China |
| | Photon Factory - Tsukuba, Ibaraki, Japan |
| | Pohang Accelerator Laboratory - Pohang, Kyungbuk, Korea |
| | SOLEIL - GIF-sur-YVETTE, France |
| | SER-CAT - Southeast Regional Collaborative Access Team |
| | SLS - Swiss Light Source (Paul Scherrer Institut) - Villigen, Switzerland |
| | Spring-8 - Japan Synchrotron Radiation Research Institute - Hyogo, Japan |
| | SRC - Synchrotron Radiation Center - Madison, Wisconsin, USA |
| | SRS - Daresbury Synchrotron Radiation Source - Cheshire, United Kingdom |
| | SSRF - Shanghai Synchrotron Radiation Facility |
| | SSRL - Stanford Synchrotron Radiation Laboratory - Stanford, California, USA |
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| Videos (Web Based) |
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| | Setting crystallization trays - Janet Smith Lab |
| | How to mount protein crystals using cryotongs - Video instruction of how to flash cool a crystal in liquid nitrogen and then mount using cryotongs on an X-ray diffractometer. |
| | Freezing crystals - Janet Smith Lab |
| | How do they grow and analyse protein crystals? - Backstage Science |
| | Time lapsed protein crystal growth - Lysozyme |
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| X-Ray Diffraction Related Companies |
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| | Area Detector Systems Corp. - CCD X-ray Detectors |
| | Bruker-Axs - Bruker Advanced X-ray Systems |
| | Mar USA (Rayonix) - X-ray Instruments fro Crystallography & Diffraction |
| | Oxford Diffraction - X-ray Diffraction |
| | Rigaku-MSC - X-Ray Diffraction, Cryogenic Systems, Contract Services |
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| Temperature Incubator |
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| | Centeo Biosciences - T-GRID temperature control system |
| | Memmert - Peltier-Cooled Incubators IPP |
| | Powers Scientific, Inc. - Protein Crystal Growth Chambers (temperature incubators) |
| | Torrey Pines Scientific - ECHOtherm Chilling/HEating Incubators 4-70 degrees Celsius |
| | Velp Scientific - Temperature Incubators |
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| Wiki |
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| | CCP4 Wiki - This CCP4 user community wiki is meant to be a collection of crystallographic knowledge as discussed on the CCP4 |
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