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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Associate Director Structural Biology
Website: https://rheosrx.com/our-workplace/careers/associate-director-structural-biology/

Description:
Title: Associate Director, Structural Biology
Department: Drug Discovery
Reports To: VP, Drug Discovery
Location: Cambridge, MA

The Company:
At Rheos, we are leading the way in the emerging field of immunometabolism to discover novel medicines to treat inflammatory-mediated diseases, including autoimmune diseases. Our medicines control metabolic pathways of immune cells that influence their activation state, in order to rebalance immune responses that cause inflammation or autoimmunity.

The Role:
The Associate Director, Structural Biology, will provide leadership and expertise in the structural characterization of Rheos’s drug targets. The ideal candidate will be focused on protein crystallography but will integrate with the drug discovery organization to implement a variety of biophysical techniques.

Major Responsibilities:
• Collaborate with colleagues in lead discovery, biology, and chemistry to develop a structural biology strategy.
• Designing biophysics-grade protein constructs and assisting in the optimization of purification protocols.
• Crystallization, X-ray structure determination, and analysis of important drug targets through working with external collaborators.
• Management of external structural biology collaborations (CROs)
• Providing regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with chemistry group.

Requirements and Qualifications:
Education:
• PhD degree structural biology or biophysics
Required Experience:
• 7+ years of drug discovery experience in a pharmaceutical/biotechnology setting;
• Demonstrated ability to solve difficult problems in protein crystallography, structural biology and biophysics
• Demonstrated competency in protein construct design and expression and purification strategies using bacterial, insect, and mammalian hosts.
Knowledge, Skills & Abilities:
• Strong knowledge of the drug discovery process, with deep experience in implementing hit identification strategies through candidate selection;
• Extensive knowledge of protein structure and function, with the ability to articulately communicate structural information to a broad audience.
• Experience with other structural techniques (e.g. electron microscopy, small-angle X-ray scattering) is preferred.

If this excites you, please submit your CV with the title of the position in the subject line to careers@rheosrx.com


[Post Date: July 19, 2018]

Title: Postdoc Biozentrum der Universität Würzburg

Description:
A PhD and a postdoc position in structural biology is available at the department of biochemistry at the Biocentre (head Prof. Utz Fischer) of the Julius Maximilians University, Wuerzburg/Germany in the field of RNP biochemistry.

The successful applicant will establish protocols for the isolation and reconstitution of preparative amounts of RNP complexes, which will then be characterized by cryo-electron microscopy and x-ray crystallography. We are looking for candidates with expertise in protein expression and purification and a strong interest in structural biochemistry. Prior knowledge of cryo electron microscopy, protein crystallography or biophysical methods is a plus.

Please send your application including a letter of interest, curriculum vitae, academic certificates and the name and contact detail of at least one referee to

Prof. Utz Fischer/Dr. Clemens Grimm
e-mail: Clemens.Grimm@biozentrum.uni-wuerzburg.de
Lehrstuhl für Biochemie
Biozentrum der Universitaet Wuerzburg
Am Hubland
D-97074 Wuerzburg
Germany


[Post Date: July 19, 2018]

Title: Research Associate Structural Biology
Website: http://files8.design-editor.com/93/9333026/UploadedFiles/7CF5EF39-B19A-4DFA-6C1C-D30A3642FD8B.pdf

Description:
There is an opportunity to join the Structural Biology team at Confo Therapeutics based in Ghent (Belgium) as Research Associate. Please see the advert in the link above. Interested candidates should apply forwarding a short motivation letter and CV to careers@confotherapeutics.com.


[Post Date: July 19, 2018]

Title: Postdoc Texas Tech University HSC

Description:
A new position is open for a membrane protein crystallographer at a postdoctoral research associate level in Guan Lab at Department of Cell Physiology and Molecular Biophysics of Texas Tech University Health Sciences Center, TX, to perform NIH-funded research projects, which involve a comprehensive structural/functional investigation of bacterial/human nutrient transporters using X-ray crystallography and other biophysical techniques.

The laboratory seeks a motivated individual with strong knowledge and expertise in protein X-ray crystallography. Experience in membrane protein biochemistry and solute transport is highly favored. Salary is competitive based on experience. For more details see:
http://www.ttuhsc.edu/medicine/cell-physiology-molecular-biophysics/faculty/guan
https://www.ttuhsc.edu/centers-institutes/membrane-protein-research

Interested applicants should submit their CV and contact information for three references along with a cover letter through our website (http://www.texastech.edu/careers/staff-positions.php) with the requisition ID of 14651BR.


[Post Date: July 17, 2018]

Title: Postdoc Structural Biology GSK
Website: https://tinyurl.com/yc4uhqpy

Description:
At GSK in Rockville, MD, USA, we have an opening for a Structural Biologist/Post Doctoral Investigator with interests and experience in vaccine research (requisition ID: WD159275). Anyone interested to apply can do so by visiting this link above.

Applications will be accepted only through the page at the link above, and some details are provided below:

Basic qualifications:
• PhD in structural biology or virology plus 0-2 years of work experience
• At least one publication in a peer-reviewed journal
• Fluency in English, spoken and written
• Must be proficient in structural biology, specifically X-ray crystallography and cryo-EM

Preferred qualifications:
• 2 plus years of work experience with PhD in Structural Biology
• Strong track-record of scientific publications in peer-reviewed journals, including at least one as first author
• Experience working in structural virology and structure-based vaccine design
• Experience with epitope mapping and prediction.
• Excellent communication and presentation skills, ability to collaborate in multiple project work streams
• Experience in structural virology and structure-based vaccine design strongly preferred.

Examples of relevant publications:

- Malito et al 2013. Finding epitopes with Computers. http://dx.doi.org/10.1016/j.chembiol.2013.10.002
- Malito et al 2015. Protein Crystallography in Vaccine Research and Development. http://dx.doi.org/10.3390/ijms160613106
- Liljeroos et al 2015. Structural and Computational Biology in the Design of Immunogenic Vaccine Antigens http://dx.doi.org/10.1155/2015/156241
- Lopez-Sagaseta et al 2016. Self-assembling protein nanoparticles in the design of vaccines http://dx.doi.org/10.1016/j.csbj.2015.11.001
- Lopez-Sagaseta et al 2018. Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp http://dx.doi.org/10.1038/s41467-018-02827-7
- Malito et al 2018. From recognition to execution — the HCMV Pentamer from receptor binding to fusion triggering https://doi.org/10.1016/j.coviro.2018.05.004


[Post Date: July 03, 2018]

Title: Postdoc Biozentrum, Basel, Switzerland
Website: https://tinyurl.com/yb7x79po

Description:
The Maier Lab is looking to recruit postdoctoral scientists to study giant multienzymes, regulatory complexes and metabolic regulation.

We employ a combination of structural biology techniques, in particular cryo-EM, X-ray crystallography and XL-MS at state-of-the-art level to resolve the architecture of large protein assemblies. Additionally, we aim to visualize dynamics of multienzyme factories and transient regulatory interactions in eukaryotic cells.

For an overview of recent research in our team, cf. Science 351, 48-52 (2016), Nature 531, 533-537(2016); Nat Chem Biol 14, 474-479 (2018), Curr Opin Struct Biol 49, 177-189 (2018); Nature 558, 470-474 (2018). For more information, follow @MaierLab on Twitter or visit www.biozentrum.unibas.ch/maier.

Our group is embedded in the focal area “Structural Biology & Biophysics”, which offers a stimulating environment for interdisciplinary research. We collaborate intensely with teams in the areas of cellular signaling and infection biology. Excellent in-house facilities for electron microscopy, proteomics, imaging, biophysics, and large-scale computing support research and training.

We are looking for enthusiastic scientists who share our dedication to solving challenging problems in biology. Postdoc candidates should have obtained their PhD recently or expect to complete their PhD soon and are expected to have demonstrated their scientific excellence by at least one strong published or upcoming first author paper.

Ideal candidates are trained in state-of-the-art structural biology of large assemblies using cryo-EM or X-ray crystallography or have specific prior experience in mTOR signaling or polyketide synthase biology. Experience in eukaryotic protein production, multi-scale modelling, super-resolution microscopy or single-molecule experiments is a plus.

The Biozentrum of the University of Basel is one of the leading institutes worldwide for molecular and biomedical basic research and teaching. It is home to more than 30 research groups with scientists from over 40 countries. Research at the Biozentrum focuses on the areas of Cell Growth & Development, Infection Biology, Neurobiology, Structural Biology & Biophysics and Computational & Systems Biology. With its more than 500 employees, the Biozentrum is the largest department at the University of Basel’s Faculty of Science. The Biozentrum is dedicated to excellence in research and education and provides outstanding training and career development support for Postdocs.

Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany-France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Please visit www.biozentrum.unibas.ch/maier for more information and a link to the online application portal. Informal inquiries via e-mail to timm.maier@unibas.ch are welcome.


[Post Date: July 02, 2018]

Title: Postdoc EMBL Hamburg
Website: https://www.embl-hamburg.de/jobs/searchjobs/index.php?ref=HH_00144

Description:
We are looking for a highly motivated Postdoctoral researcher to join our efforts in structure-based search of new drug leads. If you have experience in macromolecular crystallography, sample preparation and scientific programming, and interested in this position, please refer to the job description and application instructions at the link.

The closing date for applications is 12th August 2018.


[Post Date: July 02, 2018]

Title: Postdoc Utrecht University

Description:
Two 2.5-year ERC-funded post-doctoral positions and one 4-year PhD student positions are currently available in the group of Piet Gros on structural, biophysical and biochemical studies of the human complement system.

I am looking for highly motivated and talented researchers. Post-doc candidates with proven expertise in structural biology/protein biochemistry (PD1) or membrane biology/lipid biochemistry (PD2) are asked to apply. Candidates for the PhD position must have a MSc degree in molecular life science, (bio)chemistry, biophysics or (molecular and cellular) biology.

The Bijvoet Center Biomolecular Research at the Utrecht University offers a collaborative environment and state-of-the-art infrastructure (e.g. EM, MS, light microscopy, protein and membrane biochemistry). Cryo-EM microscopes are available at the Utrecht EM-square and national facility NeCEN.

You are asked to send in an application consisting of a CV, a motivation letter and two references, no later than August 23rd 2018 to science.secr.ks@uu.nl

Piet Gros
Bijvoet Center for Biomolecular Research
Utrecht University, Netherlands


[Post Date: July 02, 2018]

Title: Postdoc University of Oxford
Website: http://www.bioch.ox.ac.uk/aspsite/index.asp?sectionid=vacancies&job=135703

Description:
Postdoc - Department of Biochemistry, University of Oxford

We are seeking to appoint an outstanding individual with PhD training in structural biology to reveal the function of unconventional kinetochore proteins in Trypanosoma brucei, the causative agent of sleeping sickness. Although it was widely believed that all eukaryotes would have a conserved set of kinetochore proteins, we recently identified 20 uncharacterized kinetochore proteins (named KKT1–20) in Trypanosoma brucei and discovered that they constitute unconventional kinetochores specific to kinetoplastids, a group of evolutionarily-divergent eukaryotes (Akiyoshi and Gull, Cell 2014, Nerusheva and Akiyoshi Open Biol 2016). We are currently characterizing these KKT proteins using various techniques including cell biology, bioinformatics, advanced microscopy, biochemistry, biophysics, and structural biology.


[Post Date: July 02, 2018]

Title: Postdoc University of Virginia

Description:
We are interested in how cells synthesize and secrete surface polysaccharides to form cell walls and extracellular matrices. Specifically, the successful candidate will join our efforts to structurally and functionally characterize ABC transporter-mediated polysaccharide secretion. The project involves crystallographic and cryo electron microscopy techniques combined with in vitro reconstitutions of transport processes.

The University of Virginia provides an excellent environment for interdisciplinary research in microbiology, infectious diseases, and membrane biophysics. UVA maintains state-of-the-art infrastructures for structural biology, including NMR and EPR spectroscopy, electron microscopy, X-ray crystallography, and super-resolution microscopy. Interested candidates are encourage to contact me directly (jochen_zimmer@virginia.edu).


[Post Date: June 25, 2018]

Title: Structural Biology Scientist Amgen
Website: https://careers.amgen.com/job/8388823/scientist-structural-biology-cambridge-ma/

Description:
Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions. To underpin our commitment to serve patients, Amgen is significantly expanding our Research and Development facility in Cambridge MA (AMA).

We are looking for a structural biology scientist with strong background in x-ray crystallography and experience in cryo-EM to join our group in Cambridge, MA. Please apply at website.


[Post Date: June 25, 2018]

Title: Director of Institute UCL/Birbeck
Website: https://tinyurl.com/yac2ha2u

Description:
We are looking to recruit a world leading scientist to succeed Prof Gabriel Waksman FRS FMedSci as Director of the Institute of Structural and Molecular Biology at UCL and Birkbeck, University of London.

The Institute of Structural and Molecular Biology (ISMB) is a world-leading interdisciplinary institute in the field of structural, molecular and mechanistic biology, and an important strategic collaboration between UCL and Birkbeck, University of London. Research interests cover a broad range of key research questions in fundamental biology, with a particular focus on the mechanisms of molecular machines. Our approaches are at the cutting edge of interdisciplinary biomolecular science. World-class research facilities are accessible to all ISMB members, including laboratories for cryo-electron microscopy, X-ray crystallography, NMR spectroscopy, biophysical methods, mass spectrometry, computational biology, cell biology, optical microscopy and microbiology. ISMB seminars, symposia and retreats facilitate collaborative research activities, while our PhD programmes, including an ISMB Wellcome Trust funded programme, support recruitment of high-calibre students committed to interdisciplinary research. The successful candidate will have a world-class record of research in a complementary area, a shared commitment to multidisciplinary and multiscalar approaches to mechanistic biology, and a vision to lead the ISMB to the next stage of its development.

Details and the application form can be found at
https://atsv7.wcn.co.uk/search_engine/jobs.cgi?SID=amNvZGU9MTczNDQwNCZ2dF90ZW1wbGF0ZT05NjUmb3duZXI9NTA0MTE3OCZvd25lcnR5cGU9ZmFpciZicmFuZF9pZD0wJnBvc3RpbmdfY29kZT0yMjQ=

For informal enquiries, please contact Professor Frances Brodsky (Director, UCL Biosciences and Chair of the Search Committee (f.brodsky@ucl.ac.uk) or, for enquiries about Birkbeck, Professor Nicholas Keep (n.keep@bbk.ac.uk).

Closing Date 31st July 2018


[Post Date: June 21, 2018]

Title: Postdoc Umea University

Description:
The laboratory of Magnus Wolf-Watz at Umeå University is searching a motivated postdoc with an interest in enzyme dynamics. We use diverse techniques to address enzymatic rate enhancements from the perspective of enzyme dynamics. The candidate should either hold or expect to hold a Ph.D. in the area of biochemistry or structural biology, with expertise in either NMR spectroscopy or X-ray crystallography. Our department is equipped with state of the art NMR spectrometers including an 850 MHz machine equipped with a cryo probe. Expertise in protein production and purification is required.

The postdoc position is a fellowship for 2 years. Please visit the lab website for more information: www.biostruct.umu.se/principal-investigators/magnus-wolf-watz/.

Send your CV with a brief research statement as well as 2-3 contacts for references to magnus.wolf-watz@umu.se before the 1st of August


[Post Date: June 21, 2018]
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