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Crystallography related career opportunities, post docs and related positions in the crystallography community.
If you wish to place your job opportunity on the Hampton Research website, submit the details to
tech@hrmail.com.
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Post Doc University of Wisconsin at Madison
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Description:
You are invited to apply for a postdoctoral position in the structural biology lab of McArdle Cancer Institute of University of Wisconsin at Madison. We are interested in understanding the structural basis of protein phosphatase 2A (PP2A) regulation and its cross-talk to cellular and viral kinases in controlling signaling proteins involved in cell cycle, DNA damage response, and cell metabolism. One important aspect of the study is to elucidate mechanisms of protein chaperones in modulating the function of diverse PP2A complexes, kinases and nuclear receptors in response to cellular and environmental signals using structural biology techniques in combination of biochemical and biophysical methods and cell biology approaches. Initial results of this specific aspect of study can be found in our recent publications (Nat. Commun., 4:1699, 2013; Molecular Cell 41, 1–12, 2011).
The lab is equipped with a state-of-the-art setup for x-ray crystallographic studies, including crystallography robot, and have convenient monthly access to powerful x-ray beamlines at APS. The researcher will work in a multidisciplinary setup, including cell biology, biophysics, proteomics, and protein biochemistry, in addition to protein crystallography.
Candidates should hold a PhD in protein biochemistry and crystallography and have a good working knowledge of molecular biology techniques. The candidates should be highly motivated, goal-driven, and dedicated individuals who can think critically and work both independently and collaboratively with good verbal and written communication skills. It is also important that the candidates are creative in problem solving and have a strong desire to seek answers to questions related to the molecular basis of cellular processes. Experience in cell culture techniques and writing scientific research papers would be advantageous. Eligibility to training grant is appealing, but not essential.
This is a full-time position with a starting salary of $39,264 – 44,340 per year depending on skills and experience.
Review of applications will begin immediately and continue until the positions are filled.
To apply: Please send a cover letter, CV and the names and contact information for three references to Dr. Yongna Xing, 1400 University Avenue, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison-Madison, WI 53706. Email: yxing@oncology.wisc.edu.
[Post Date: May 23, 2013]
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Post Doc Karolinska Institutet
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Description:
A two-year post-doctoral position is available from September 2013 at the Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, Stockholm. The project deals primarily with over-expression, purification, crystallization and structure determination of human membrane proteins involved in the generation of lipid mediators of inflammation, belonging to the MAPEG (membrane associated proteins in eicosanoid and glutathione metabolism) superfamily. The successful candidate will join a multi-disciplinary research team and the position represents an opportunity for a postdoctoral scientist to develop his/her expertise as well as broaden his/her experience. The broad interests of the lab are in membrane protein structure and function. We will combine structural techniques such as macromolecular crystallography with biophysical and biochemical methods such as enzyme kinetics to investigate the structural bases of the catalytic mechanisms. The lab has all necessary equipment and access to facilities needed for the project. We have periodic access to beamlines at ESRF (France), Diamond (UK) and Bessy (Germany).
Qualifications:
The candidates should hold a Ph. D. degree, must be motivated and a have strong background in biochemistry or structural biology. Experience with protein expression, purification and biochemical characterization is required. Prior experience in membrane protein biochemistry will be added advantages.
The application should contain a single PDF document including:
Letter of intention stating the scientific interests, technical skills, and previous experience of the candidate.
C.V. including date and field of (expected) graduation and list of publications.
The contact information of at least two references.
Please send your electronic application to:
Agnes.Rinaldo-Matthis@ki.se before 1st of Aug 2013.
[Post Date: May 23, 2013]
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Title:
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Scientist / Protein Crystallographer
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Description:
The Philipps University of Marburg and the Max Planck Institute for Terrestrial Microbiology have recently established the center for Synthetic Microbiology, SYNMIKRO (www.synmikro.com). Supported by the state of Hessen within its excellence program LOEWE, the more than 30 research groups in SYNMIKRO focus on basic aspects of synthetic biology on all levels of microbial function, ranging from the development of regulatory circuits, genetic codes, and metabolic pathways to the synthesis of new minimal cells and microbial communities. To strengthen its activities in structural biology, SYNMIKRO seeks a Scientist / Protein Crystallographer for its automated crystallization facility for biological macromolecules (MarXtal). The position is available from now on for initially up to 31/12/2015 and will offer the possibility of further scientific qualification in the frame of the assigned duties. Salary and benefits are according to a public service position of the state of Hessen (TV-H E 13).
The position requires a PhD degree in biology or biochemistry. Candidates document their expertise in protein biochemistry and their profound knowledge in crystallization and protein structure determination by X-ray crystallography. Experience in laboratory robotics or usage of synchrotron sources is an advantage.
We provide support by a technician and encourage the development of independent research projects. SYNMIKRO offers an international and interdisciplinary environment at the intersection of the Max Planck Institute for Terrestrial Microbiology, the LOEWE Center for Synthetic Microbiology (SYNMIKRO) and the Philipps-University of Marburg with over 30 research groups. The beautiful and green city of Marburg offers a high quality of living in the heart of Germany.
For more information please contact Dr. Simon Jörres (simon.joerres@synmikro.uni-marburg.de).
We support women and particularly invite them to apply. Applicants with children are welcome - the Philipps University is certified as a family friendly university. Sharing a full-time position (§ 8 Abs. 2 Satz 1 HGLG) as well as a reduction of working time is possible. Applicants with a disability as described in SGB IX (§2 Abs. 2, 3) will be preferred in case of equal qualifications.
As the documents will not be returned after end of the selection procedure, please do not send originals. Application and travel expenses as well as interview costs cannot be refunded.
Please send your application mentioning the registration number ZE-0035-synmikro-wmz-2013 and including a cover letter, CV, publication list, contact data of three referees and copies of relevant documents as one single PDF file to: jobs@synmikro.uni-marburg.de or postal to: LOEWE Center for Synthetic Microbiology, Hans-Meerwein-Strasse 6, 35032 Marburg. Application deadline is June, 14th, 2013.
[Post Date: May 23, 2013]
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Title:
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Research Assistant Trinity College
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Description:
Research Assistant – Membrane Protein Production/Crystallization
Membrane Structural and Functional Biology – Caffrey Lab
Trinity College Dublin, Ireland
Post Summary
The Membrane Structural and Functional Biology group seeks to solve the crystal structure of medically important membrane proteins for use in structure/function studies and for structure-based therapeutics development. Target proteins are involved in diabetes, obesity, cancer and pain and in communicable and other non-communicable diseases. In support of this activity, we seek a highly motivated, skilled and committed Research Assistant.
The Research Assistant will have primary responsibility for routine, repetitive and proven/robust molecular cloning, insect cell maintenance, insect cell-based biomass production, protein purification and biochemical/biophysical characterization of membrane proteins, and for manual and robotic crystallisation extending from plate and screen preparation, to setup and evaluation, and on to archiving trial data. The Research Assistant will share responsibility for preparing common buffers stocks (for SDS-PAGE, DNA gels, protein purification and crystallization, etc.), LB liquid and solid medium/plates, E. coli cell-culture and molecular cloning, membrane washing (for protein purification), and regenerating resins. The Research Assistant will help with maintaining lab instruments, databases and inventories and with administration.
Person SpecificationQualifications
• Minimally, a primary (B.S., B.Sc. for example) degree with experience in molecular cloning, recombinant protein production, purification, and functional characterization
Knowledge & Experience
• Experience working in a wet biochemistry/molecular biology laboratory
• Experience using computer controlled equipment
• A high degree of manual dexterity
• Must be detail oriented and a meticulous record keeper
• Desire to learn about and to work with membrane proteins and membrane protein crystallization
• Willingness and freedom to travel between Ireland and mainland Europe and the USA
• High self-motivation
• Demonstrated ability to achieve results on time and on target
• Good analytical ability, and reasoning and organization skills
• Good written and verbal communication skills
• Commitment to team work
Training and support will be provided by in-house staff in all of the specialty methods and protocols used.
Salary €29,342 per annum
Closing Date 12th June 2013
Principal Investigator Prof. Martin Caffrey - martin.caffrey@tcd.ie
Application Procedure
Candidates are asked to submit a letter detailing education, training and laboratory experience. In the letter the candidate should outline why they feel they are suitable for the position in an interdisciplinary group that will involve extensive interaction with collaborators around the globe. The letter of application must be accompanied by a full CV to include the names and contact details of two referees (email addresses and phone numbers to be provided). At least one referee should be an individual the candidate has worked with and who has agreed to provide a letter of reference on the candidate’s behalf.
Applications should be emailed to: Shuang Leng LENGS@tcd.ie
[Post Date: May 20, 2013]
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Title:
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Post Doc University of Texas Medical Branch
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Description:
A post-doctoral position is available in Dr. Kay Choi’s laboratory at the University of Texas Medical Branch for either an X-ray crystallographer or a Biochemist to study the structure and mechanism of viral replication complexes. We use a combination of X-ray crystallography, cryo-electron microscopy, protein chemistry, and bioinformatics to determine the structure of viral replication machinery and to develop antiviral therapeutics.
The X-ray crystallography resources include two X-ray area detector systems, a Phoenix crystallization robot, a Minstrel crystal imaging robot, and an Alchemist liquid handling robot. The cryoEM facility includes two JOEL 200 keV cryoEM microscopes for high-resolution imaging work, FEI vitrobot, and a BSL-3 room for viral and pathogen work.
Applicants should possess a PhD in structural biology or biochemistry with a sound knowledge of protein purification. Individual with a biochemistry background who wishes to gain expertise in structural biology is encouraged to apply. Interested parties should send a cover letter, a CV and a list of 2-3 references to Dr. Kyung (Kay) Choi via e-mail at kychoi@utmb.edu.
[Post Date: May 20, 2013]
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Description:
Following on a BBSRC New Investigator Award, a post-doctoral position is available immediately in the laboratory of Dr. Alessandro Vannini, Division of Structural Biology at The Institute of Cancer Research in London (www.icr.ac.uk/alessandrovannini). We are looking for highly motivated and creative individuals with a strong interest in structural characterization of large multi-subunit complexes. We currently employ single particle electron microscopy analysis and x-ray crystallography, as well as biochemical and biochemical analysis, to elucidate the role of the RNA Polymerase III transcription apparatus in cancer and other fundamental cellular processes.
The Division of Structural Biology has managed facilities for protein crystallography (Bruker Microstar and CCD detector and crystallisation robots), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60 L fermentor). The Division is also well equipped with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering).
Applicants should possess a PhD (or equivalent) in biochemistry or molecular biology with a sound knowledge of multi-subunit complex production and purification. Experience in purification of multi-subunit protein complexes and yeast genetics is essential for this post. Experience in protein crystallography and/or single particle electron microscopy and protein production in insect cells (MultiBac) would be desirable, but individuals with a strong background in yeast genetics and/or biochemistry of multi-subunit complexes wishing to learn structural biology techniques will be taken into serious consideration.
Appointment will be on Fixed Term Contract for 2 years in the first instance, with a starting salary in the range of £28,087 to £33,318 p.a. inclusive (based on previous post-doctoral experience).
Informal enquiries to alessandro.vannini@icr.ac.uk and applications must be submitted in line with the instructions on our website: http://www.icr.ac.uk/jobs/index.shtml, quoting reference 1336320.
Closing date June 20th 2013.
[Post Date: May 20, 2013]
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Title:
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PhD position at the Gene Center
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Description:
A PhD position is available starting immediately at the Gene Center, Ludwig-Maximilians-Universität (LMU) Munich, in the research group of Prof. Dr. Mario Halic. Project involve crystallization and cryo-EM studies of proteins involved in RNAi and heterochromatin formation in fission yeast. Candidates must be motivated and familiar with molecular biology and biochemistry techniques. Applicants must hold a master’s degree in molecular biology, biochemistry, chemistry or equivalent. Interested candidates are requested to send their CV, summary of previous research experience and 2 references to halic@lmb.uni-muenchen.de.
[Post Date: May 17, 2013]
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Title:
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Post Doc Swiss Federal Institute of Technology
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Description:
A postdoctoral position is available at the Laboratory of Structural Biology and Biophysics at the Swiss Federal Institute of Technology in Lausanne (Ecole Polytechnique Fédérale de Lausanne, EPFL).
Research topic: Structure and function of large, multicomponent biological macromolecular complexes such as the bacterial type VI secretion system (T6SS), R-type pyocins, and selected tailed bacterial viruses (bacteriophages).
Research methods: A hybrid approach involving a combination of X-ray crystallography, electron microscopy, bioinformatics, and microbiology/molecular biology.
Location and work environment: http://maps.google.ch/maps?q=bsp+415 and http://information.epfl.ch/page-16430-en.html
Salary: Very high.
Required skills: Experience in all aspects of X-ray crystallography, strong publication record, some teaching experience.
Teaching duties: About 2 academic hours per week during autumn and spring semesters.
Highly desired skills: Driving license, background in physics (to participate in physics teaching curriculum), some knowledge of French.
Starting date: As soon as possible.
Duration: The contract is renewable every year for up to 5 years.
For application and additional information please contact Prof. Petr Leiman (petr.leiman@epfl.ch)
[Post Date: May 16, 2013]
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Description:
Protein crystallography scientist Phase Solutions is a Swiss based company owned and run by scientists motivated by inventions and discoveries. The team is experienced in working with solid state materials, powder, and minerals. Their research has, among others, been applied in pharmaceuticals, mining, art and archaeology. It is the team that has spearheaded new fields in crystallography. The company was founded in 2010 in Lausanne Switzerland and since then has offered services to many prestigious companies.
Phase Solutions has access to the best equipment in Europe, which enables scientists to give precise results to their clients.
Requirements
Phase Solutions is looking for a part time (project based) scientist, which will work in analysing and writing reports on protein crystallography. The company will make the necessary X-ray diffraction measurements, which will be shared with the scientists, either with laboratory equipment or with synchrotron. The task of the scientist will be to provide analyses and interpretation of the results. The results will be presented to the client.
The candidate should:
- Have at least 5 years of experience in protein crystallography
- Have a PhD in crystallography or related subject/or an advanced PhD student with relevant experience
- Have a good command of English
- Be ready to work from home
Advantages
University Professors working in universities close to Switzerland
Knowledge of German and French
Readiness to have their portrait featured in Phase
Solutions Web site
Please send us your CV no longer than 2 pages. Motivation letter is not required at this stage. Phase Solutions will contact candidates to be included in a roster of experts. Phase Solutions will engage scientists on project bases paid on a previously made agreement. Only selected candidates will be contacted.
Please send your CV at: jobs@crystallography.ch
No phone calls please.
[Post Date: May 13, 2013]
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Title:
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Post Doc MRC Laboratory of Molecular Biology
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Description:
MRC Laboratory of Molecular Biology, Cambridge, UK
Post-doctoral Scientist Position
We seek to appoint a postdoctoral researcher to the Division of Structural Studies to undertake protein crystallographic analysis of the anaphase promoting complex (APC/C) and its subunits. This is an Investigator Scientist position funded by Cancer Research UK for 3 years and is located at the MRC Laboratory of Molecular Biology in Cambridge, UK within the group of David Barford.
The Investigator Scientist will join a team investigating the structure and mechanism of the anaphase promoting complex (APC/C), a large macro-molecular assembly that regulates progression through the cell cycle. The project will focus on crystal structure determination of the whole APC/C and APC/C subunits and sub-complexes. This project extends our existing 11 Å resolution structure determined using single particle electron microscopy and takes advantage of our recombinant over-expression system for reconstituting APC/C (da Fonseca et al., (2011) and Schreiber et al., (2011)). The project would suit a highly motivated and committed scientist interested in molecular mechanisms of the cell cycle, cancer biology and structural biology.
The successful applicant will hold at least a PhD (or equivalent) in a biological/physical science. Experience with protein crystallography is essential and experience with protein crystallisation and purification would be an advantage.
The post is available from 1st October 2013 (or earlier). The starting salary will be set within £26,282 to £31,686. However, the full salary range for a position of this type is from £26,282 - £37,040.
Informal enquires may be made to David Barford (David.Barford@icr.ac.uk).
[Post Date: May 13, 2013]
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Description:
Opening for Associate/Assistant Professor Position in the Department of Biophysics, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, INDIA.
Research experience: preference to Neuroscience/membrane proteins.
Here is the link to the advertisement:
http://www.nimhans.kar.nic.in/notifications.htm
The last date for receipt of Application: 05 Jun 2013
[Post Date: May 13, 2013]
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Title:
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Post Doc Brown University
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Description:
The Page Laboratory at Brown University has an opening for a highly motivated postdoctoral research scientist to undertake structural analysis of signaling complexes, with a focus on the interactions between phosphatases, kinases and their regulatory proteins. Most studies typically employ a combination of x-ray crystallography, NMR spectroscopy and SAXS. Applicants with a strong background in biochemical techniques and structure determination are encouraged to apply.
The Page laboratory is housed in a 105,000 sq. ft. research laboratory in Providence, RI. The laboratories are open-lab-space facilities and allow for close interactions with the adjunct structural biology and molecular biology groups at Brown University. Recent upgrades to the Brown University structural biology infrastructure include new X-ray crystallography instrumentation (Rigaku FR-E+ SuperBright with VariMax-HF ArcSec optics, a Saturn 944 CCD detector and ACTOR robotic crystal mounting system), a BIOSAXS-1000 small angle X-ray scattering instrument, and the addition of an 850 MHz NMR spectrometer.
Providence, RI, is located on the coast between Boston (45 min.) and New York City (3 hours). Starting date, salary and project details are negotiable.
Please e-mail a Cover Letter and CV to Rebecca Page (Rebecca_Page@brown.edu), Brown University, Box G-E4, Providence, RI 02912.
[Post Date: May 13, 2013]
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Title:
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Post-doctoral position at Harvard Medical School
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Description:
A post-doctoral position is available to study the molecular mechanism for self vs. non-self discrimination by the innate immune system. We use a combination of X-ray crystallography, biochemistry and cell biology to characterize structures and functions of key host molecules that recognize foreign molecules, in particular viral nucleic acids.
Applicants should have received a PhD and have a strong background in X-ray crystallography, biochemistry, RNA biology, immunology or virology.
Please send a cover letter, CV, names, e-mail addresses and telephone numbers of three references to Sun Hur at Sun.Hur@childrens.harvard.edu
For more information, visit http://labs.idi.harvard.edu/hur/
[Post Date: May 07, 2013]
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Description:
Protein Crystallography Software Product Manager
Waltham, Massachusetts
Located in Waltham, Massachusetts, Formulatrix is a small, fast growing, and strongly profitable company. We supply robotic automation, scientific instruments, and software solutions to the life sciences industry. Our business is international in scope with offices in the United States, Europe, and Asia.
Formulatrix requires hard work and dedication from our employees. In return, we offer exciting engineering challenges, a rewarding salary and benefits package, an informal work environment, and excellent growth opportunities.
SEEKING Protein Crystallography Software Product Manager: Waltham, MA
We are seeking a senior product manager for our protein crystallography software, Rock Maker. The position requires a hands-on, organized, and detail-oriented person able to work in a fast-paced environment. The candidate will be responsible for prioritizing and defining features of Rock Maker as well as working with customers to get their feedback. This person will be involved with new installations, training, documentation, and communications. The candidate will have a strong user-centered software design philosophy, excellent communication, cross-group collaboration, and planning skills. You will need to be able to make forward progress despite ambiguous circumstances.
This position acts as a representative for users within the company, helping to shape the look, feel, flow and functionality of the software. Candidates must work well independently, with worldwide team members, and with customers.
Qualifications:
• Bachelors of Science Degree. Advanced degree in biology, chemistry or equivalent preferred.
• Experience with protein crystallography required. PhD in protein crystallography highly preferred
• Extremely strong leadership and communication skills.
• Excellent prioritization, organizational and planning skills.
• Experience with graphical user interface design preferred.
• Experience with the entire software development lifecycle preferred.
• Excellent verbal and written communication skills.
• Quick learner.
• Candidates should be eager to work in this challenging environment at a minimum of 50 hours per week.
• Up to 50% travel required.
Formulatrix hires only hard working individuals that commit whole heartedly to any challenge they take on. Compensation will include equity. However, as with all management and engineers at the company, we expect candidate to work a minimum 50 hour work week.
How to apply:
** RESUMES SUBMITTED WITHOUT THE INFORMATION REQUESTED BELOW WILL NOT BE CONSIDERED **
To be considered for this position, please email jobs@formulatrix.com with the words “RM USA” in the subject line. You must include a copy of your resume, (Word, HTML, plain text or RTF only) and answer the following three questions in the body of your email:
• What are your salary requirements?
• When can you start?
• Are you authorized to work in the United States?
[Post Date: April 30, 2013]
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Title:
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PhD and Post Doc Positions Duke-NUS-GMS
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Description:
A PhD student and a postdoctoral position are available at The Duke-NUS GMS (Singapore) under the supervision of Dr Shee-Mei Lok. In our laboratory, we use a combination of techniques such as x-ray crystallography and cryo electron microscopy to investigate dengue virus complexes and its structural change during viral infection. We have the state-of-the-art facilities in cryoEM such as The FEI Titan Krios, phase plate, liquid cell system to investigate both frozen and liquid forms of the sample.
For the postdoctoral position, candidates with a Ph.D in structural biology such as x-ray crystallography and cryoEM within 2-3 years of their graduation are encouraged to apply. Interested candidates are requested to send their CV, summary of research interests and names of 3 references to sheemei.lok@duke-nus.edu.sg.
[Post Date: April 29, 2013]
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Title:
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Post Doc Structural Virology
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Description:
A postdoctoral position is available starting immediately to continue the structural work on adenovirus capsids and associated proteins (Reddy et al., Crystal structure of human adenovirus at 3.5Å resolution. Science. 2010;329(5995):1071-5) at The Scripps Research Institute, La Jolla, California, in the research group of Vijay Reddy.
Candidates with a Ph.D in biochemistry or structural biology and within 2-3 years of their graduation are encouraged to apply. Hands on experience and knowledge in protein expression, purification and aspects of structure determination employing x-ray crystallographic methods are essential for the intended position. Interested candidates are requested to send their CV, summary of research interests and names of 3 references to reddyv@scripps.edu
[Post Date: April 26, 2013]
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TECHNICAL SUPPORT
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Tel: 949-425-1321
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Fax: 949-425-1611
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Email: tech@hrmail.com
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LOCATION
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Hampton Research
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34 Journey
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Aliso Viejo, CA 92656-3317
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Toll Free: 800-452-3899
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Tel: 949-425-1321
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Fax: 949-425-1611
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BUSINESS HOURS
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7:00 am to 5:00pm
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Monday - Friday
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(Pacific Standard Time)
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