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Crystallography related career opportunities, post docs and related positions in the crystallography community.
If you wish to place your job opportunity on the Hampton Research website, submit the details to
tech@hrmail.com.
Description:
A recently funded project entitled “New Targets to Address Old Problems in Oncology” is recruiting personell. The goal of the project is to assess the feasibility of driving cancer cells into apoptosis by inhibiting transcription coupled repair (TCR) of DNA. The person will form part of a team of 3 working to develop small molecule inhibitors of the Cockayne Syndrome B (CSB) protein that initiates TCR. The project is a collaboration with the group of Prof. Leon Mullenders at the Leiden University Medical Center, while two companies ZoBio and Prestwick Chemicals, will provide support in the area of chemistry. My group will be responsible for the discovery and validation of small molecules that bind to and inhibit CSB. We will then use structural biology to enhance the potency of the CSB ligands. The group of Prof. Mullenders will develop in vitro and in vivo assays to determine the mode of action of the inhibitors and help to achieve the ultimate goal, that is to determine whether inhibition of CSB selectively drives cancer cells into apoptosis. We are currently seeking an an experienced, motivated post-Doc for three years with experience in X-ray crystallography.
To apply please send a letter of motivation, your CV and the names and contact information of preferably 3 people willing to provide references to g.siegal@chem.leidenuniv.nl.
[Post Date: January 31, 2012]
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Title:
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Three post doc positions
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Description:
Three post-doctoral positions are available to join a multi-disciplinary research group investigating the regulation of biological motors activity from the cellular to the molecular level. The group is formed by the laboratories of Gary Gerfen, Ao Ma, David Sharp and Hernando Sosa in the Department of Physiology and Biophysics of the Albert Einstein College of Medicine. For these positions the ideal candidates would have experience in the general areas of cell biology, structural biology, molecular simulation and statistical mechanics. Expertise with one or more of the following techniques will be required: protein expression and purification, cell imaging, electron paramagnetic resonance (EPR), electron microscopy and molecular dynamics simulations.
For this project we have state of the art facilities present in each of the participating laboratories and at the core facilities of the Albert College of Medicine. These capabilities include EPR (PELDOR, high frequency, HYSCORE), several modalities of fluorescence microscopy (con-focal, epi, tirf, single-molecule polarization etc), cryo-electron microscopy and state-of-the-art Linux clusters for molecular simulations. All four laboratories in the group are located in the Albert Einstein College of Medicine in New York City, which offers excellent opportunities for stimulating and highly inter-disciplinary scientific interactions within the group, between theory/simulation and experiments, with the rest of the college and with many other scientific institutions in the New York area. Interested candidates please send an email letter, CV and reference names to either: Gary Gerfen (gary.gerfen@einstein.yu.edu), Ao Ma (ao.ma@einstein.yu.edu), David Sharp (david.sharp@einstein.yu.edu), Hernando Sosa (hernando.sosa@einstein.yu.edu).
Yeshiva University is an equal opportunity employer committed to workforce diversity.
[Post Date: January 26, 2012]
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Description:
PhD and Postdoc opportunities in Singapore in Structural Biology.
The Bob Robinson laboratory is looking for candidates to apply for a range of scholarships and fellowships in conjunction with the laboratory. Joining the laboratory will be conditional on securing the award.
The laboratory, in the Institute of Molecular and Cell Biology (IMCB), uses structural biology techniques to study 1) how the power generated from actin-filament polymerization is harnessed by biological processes, 2) the breadth of structures and dynamics that are formed by diverse bacterial actin-like filament systems, and 3) how these structures may be interfered with in the search for novel drug candidates. The laboratory uses a variety of techniques, including: protein crystallography, electron microscopy, TIRF microscopy and SILAC mass spectrometry.
1) European-based researchers to apply for the EMBO Long-Term Fellowship (postdoc).
http://www.embo.org/programmes/fellowships/long-term.html
2) Potential PhD students to apply for NGS and SINGA scholarships.
https://www.singa.a-star.edu.sg/
http://www.nus.edu.sg/ngs/scholarships.html
3) Potential joint PhD students to apply for ARAP Scholarships.
http://www.a-star.edu.sg/tabid/424/default.aspx
4) Singaporean Students to apply for AGS scholarships.
http://www.a-star.edu.sg/tabid/424/default.aspx
Interested candidates should contact Bob directly:
Website: http://www.imcb.a-star.edu.sg/php/robinson.php
email: rrobinson@imcb.a-star.edu.sg
[Post Date: January 20, 2012]
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Title:
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Director of Protein Production
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Contact:
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Crystal Love
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Email:
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clove@nysbc.org
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Description:
The New York Structural Biology Center (NYSBC) is looking for a highly motivated individual to lead its protein production division. This will entail leading a minimum of two projects engaged in high-throughput protein production. Each of these projects employs a team of technical staff and Ph.D.-level scientists who will report directly to the successful candidate. One current project concerns the New York Consortium on Membrane Structure (NYCOMPS) an NIH-supported PSI:Biology Center for Membrane Protein Structure Determination. Protein production in NYCOMPS includes a robotic high-throughput cloning platform and protein production and characterization pipeline with numerous automated elements. A second funded project, involving a separate team, focuses on high-throughput protein production and structure determination of targets from pathogenic organisms and structural studies on selected eukaryotic proteins. Protein production at NYSBC currently involves a staff of
10 including 5 Ph.D. scientists, and this group may expand in the future.
The successful candidate will have entrepreneurial interests, be open to new challenges, and be ready to seize opportunities. He or she will have deep knowledge of prokaryotic and eukaryotic protein expression and purification methods and high-throughput production technologies. A Ph.D. (or equivalent) in a relevant area is required, as well as ample postdoctoral experience. Expertise with integral membrane proteins and/or x-ray crystallography would be helpful, but are not absolute requirements. Good communications skills are a must, as the successful individual will act as a liaison with funding agencies and collaborating scientists, and provide outreach to the larger scientific community. Responsibilities will also include fulfilling all reporting requirements of the external funding agencies.
NYSBC is a not-for-profit consortium of 10 of New York’s preeminent biomedical research centers that specializes in structural biology research and research resources. NYSBC is well known throughout the world for its extraordinary facilities and research projects in structural biology. We offer an excellent compensation package, health benefits and immediate participation and full vesting in the NYSBC’s retirement plan.
Interested applicants should contact: Crystal Love (clove@nysbc.org)
[Post Date: January 17, 2012]
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Description:
Postdoctoral Position in Mechanistic Enzymology at the University of Iowa
The Dey lab in the Department of Chemistry at the University of Iowa seeks to recruit an outstanding postdoctoral scientist with experience and/or interest in mechanistic enzymology. The successful candidate will be responsible for the characterization of enzymes involved in one of the research areas of the lab: methanogenesis; sulfur metabolism; mammalian oxygen sensing. The lab uses a combination of biochemical, structural, and spectroscopic techniques to investigate enzyme catalysis. Previous experience in structural biochemistry and enzymology would be valuable. This position provides the opportunity for broad training in protein expression, crystallization, kinetics, spectroscopy, genetics, and molecular biology.
Candidates must have their Ph.D. by the beginning date of the appointment in Biological Chemistry or a related discipline (Chemistry, Biochemistry, Molecular Biology and Biophysics, Microbiology, Pharmaceutical Sciences, Biochemical, and Biomedical engineering). The successful candidate will have strong experience in molecular biology, protein expression, purification, crystallization, and functional analysis. A significant publication record is an advantage. The candidate must have the ability to work independently and in a team.
For a complete job description and to apply go to http://jobs.uiowa.edu and apply to requisition #1717.
The University of Iowa is an equal opportunity affirmative action employer. Women and minorities are encouraged to apply.
[Post Date: January 16, 2012]
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Description:
X-Ray Crystallographers within our Structural Biology Department
Salary: £23,000 - £39,000 + benefits
Location: Oxfordshire, UK
Full time; Permanent
Evotec (UK) Ltd is currently seeking X-Ray Crystallographers for our Structural Biology Department based in Oxfordshire. X-Ray Crystallography works closely with our Discovery Chemistry Department and with clients to develop novel small molecule drugs. The group is at the forefront of new science and technology, and is seeking to expand as business need grows.
The successful candidates will be part of the Structural Biology group responsible for expression, purification, crystallisation and structure determination of proteins and protein-ligand complexes. Knowledge of state of the art crystallographic methods is a must, along with skills in molecular biology and protein purification. Expertise in protein-ligand complex crystallisation problems would be an advantage though not essential.
You will have excellent written and verbal communication skills and will be a strong team player. Dynamic and innovative, you will be a self-starter with a flexible approach who enjoys a challenge.
You will be PhD qualified or equivalent in Chemistry, Biochemistry, Molecular Biology or Biophysics, with experience in protein X-ray crystallography. Candidates will also be considered who have a Masters degree with extensive experience or equivalent.
We offer competitive salaries plus extensive benefits including annual bonus, pension plan, private medical and dental cover.
If you feel that your skills and experience match what we are looking for, please apply by emailing your CV, a brief statement of research accomplishments and interests to humanresources-abingdon@evotec.com or to post it to:
Evotec (UK) Ltd
Human Resources
114 Milton Park
Abingdon
Oxfordshire
OX14 4SA
United Kingdom
Evotec (UK) Ltd is a limited company registered in England and Wales. Registration number:2674265. Registered Office: 114 Milton Park, Abingdon, Oxfordshire, OX14 4SA, United Kingdom
[Post Date: January 13, 2012]
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Description:
Company Biogen Idec
Job Title Associate Scientist III, Crystallography
Internal Job Number 16738BR
Status Full Time
Country US
City Cambridge
State/Province MA
Postal Code 02142
Job Description We are seeking an enthusiastic and creative crystallography associate scientist to support antibody engineering and small molecule drug discovery efforts in our structural biology group The Research Associate will provide protein crystallization support for a gene-to-structure team working towards structure-based drug design. This highly organized individual will engage in biochemical characterization, protein crystallization, and crystal cryoprotection for data collection. Protein production for selected needs will also be performed from cloning to purification for crystallization. The individual is expected to work in a highly collaborative environment, demonstrate initiative in solving difficult technical challenges and work simultaneously on multiple projects. The position will include use of biophysical methods to demonstrate protein/protein and protein/ligand interactions in support of crystallization and drug candidate characterizations.
Qualifications Familiarity with techniques of protein expression and purification for crystallization and as well as crystallization is essential. Hands-on knowledge of cloning, mutagenesis, and protein chemistry is highly desired. A demonstrated ability and desire to rapidly and independently become proficient in new and diverse experimental techniques will be needed. The candidate must be a team player with excellent organizational, experimental data recording and time management skills
Company Profile About Biogen Idec: A Biotechnology Pioneer
Biogen Idec uses cutting-edge science to discover, develop, manufacture and market biological products for the treatment of serious diseases with a focus on neurological disorders. Founded in 1978, Biogen Idec is the world's oldest independent biotechnology company. Patients worldwide benefit from its leading multiple sclerosis therapies, and the company generates more than $4 billion in annual revenues.
Learn more at www.biogenidec.com/careers.
Biogen Idec is proud to be an equal opportunity employer.
[Post Date: January 12, 2012]
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Description:
We are seeking a talented and self-motivated professional with expertise in the area of protein expression and purification. The successful candidate will be responsible for optimizing existing methods, trouble shooting, and developing new strategies for protein production in E. coli and other heterologous systems. Day-to-day responsibilities include protein purification, expression vector construction, screen and evaluation of protein expression in bacterial and other heterologous systems. The candidate is expected to have an ability to work in a fast paced, time-line driven, team based environment, and to interact effectively with scientists in other teams.
Qualifications, Education/Work experience: PhD with two plus years of postdoctoral research experience or MS with five plus years of working experience in biochemistry or other biological science areas. This individual must possess a good understanding of protein biochemistry. Hands-on experience in protein purification or molecular cloning is required. Experience in expression of recombinant proteins in multiple expression systems (E.coli, insect, yeast, and plant) and membrane protein purification will be given preference. Excellent oral and written communication, data documentation, and presentation skills are required.
Please direct informal inquiries to Dr. Kirk Narzinski, kdnarz@monsanto.com
Actual applications may only be accepted via the hiring portal: http://www.monsanto.com/careers/pages/jobsearch.aspx
look for application number 005QV – “Research Scientist- Protein Expression/ Purification”
Monsanto is an equal opportunity employer; we value a diverse combination of ideas, perspectives and cultures. EEO/AA EMPLOYER M/F/D/V
[Post Date: January 12, 2012]
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Description:
Structural Bioinformatics Lab, Department of Biotechnology & Bioinformatics, Korea University, Seoul Korea Brainpool Research Associate – Full time, fixed term appointment for up to two years
The Structural Bioinformatics Lab is seeking a Brainpool Research Associate to carry out structural analysis (x-ray crystallography) and biophysical studies of complexes related to virus-host interaction. The group is led by Professor Kyung Hyun Kim and has over the years produced good results (PNAS, NAR, JGV). The research programme is funded by a grant from the Korean Federation of Science and technology Societies (www.brainpool.or.kr) to which both the applicant and our team apply together. Further details on the research group can be found at http://sbl.korea.ac.kr/.
Applicants should have a PhD in Structural Biology, Biophysics or a related area, with at least 5 years of research experience after Ph.D., or high profile publications in the highest impact journals.
Salary range will be from $45,000-$55,000 per annum plus plane ticket, moving expense and medical insurance. Initial salary for possibly the two months will be dependent on the skills and experience of the successful applicant.
Closing date for completed applications: 5 February 2012. To apply for this position please send emails to khkim@korea.ac.kr with your resume.
Korea U is an equal opportunities employer and encourages applications from all candidates irrespective of gender, race, disability, sexual orientation, age, religion and belief or another protected characteristic.
[Post Date: January 11, 2012]
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Title:
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Post Doc Cold Spring Harbor Laboratory
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Contact:
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Hiro Furukawa
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Email:
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furukawa@cshl.edu
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Description:
A postdoctoral position at Cold Spring Harbor Laboratory (CSHL) is available to study molecular mechanisms of ion/substrate transport and enzymatic processes at the biological membrane by structural, electrophysiological, and biochemical approaches. We are particularly interested in studying molecules that are involved in the pathology of neurodegenerative diseases such as Alzheimer’s disease.
We are equipped with a state-of-the-art facility to conduct cutting-edge membrane/glyco protein crystallography including a high-throughput protein screening system, an automated crystallization screening device, and the most recently updated home x-ray source. We are also set up to conduct other biophysical experiments including electrophysiology, isothermal titration calorimetry, and fluorescence-based assays such as FRET to validate structure-based functional hypotheses. CSHL is located in the suburb of New York City and is within 45 min driving distance from the National Synchrotron Light Source at Brookhaven National Laboratory. A highly collaborative environment and meetings and courses at CSHL provide unique opportunities to interact with scientists from various fields within and outside of CSHL.
Candidates must hold (or soon expect to hold) PhD in biochemistry, molecular biology, biophysics or related fields. Strong background in molecular biology, biochemistry, or cellular biology is required. Experiences in large-scale protein expression in eukaryotic cell-lines and x-ray crystallography are desirable but not necessary. Applicants with experiences in electrophysiology, and brain biochemistry are highly welcome. For more information, please check the laboratory website (http://www.cshl.edu/Faculty/furukawa-hiro.html) and contact via email. Please send CV, a brief summary of research experience and interest, and three references to Hiro Furukawa by email at furukawa@cshl.edu
[Post Date: January 10, 2012]
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Description:
Membrane Protein X-ray Crystallographer and Project Leader position at Emerald BioStructures
Emerald BioStructures is an integrated gene-to-structure collaborative research organization specializing in drug discovery services. Our scientists provide integrated structural biology solutions to pharmaceutical, biotechnology and research institutions. We have become leaders in automated, full-pipeline, gene-to-structure crystallography services, and we are making significant investments in membrane protein services.
We are searching for an experienced X-ray crystallographer who can manage client projects and contribute to our growing offerings in the areas of membrane protein structural biology and biophysical screening services. X-ray crystallographers with experience expressing, purifying, and crystallizing or characterizing GPCRs are especially encouraged to apply. X-ray crystallographers with experience performing small molecule screening using Surface Plasmon Resonance (SPR) are also encouraged to apply.
Candidates must hold a PhD in structural biology or closely related field. The successful candidate will collaborate with a diverse group of scientists in a dynamic, fast-paced environment requiring exceptional organizational and communication skills. In addition to driving the scientific progress of structural biology collaborations, the successful candidate will be responsible for managing project costs and timelines to ensure profitability within our contract research environment.
We offer a competitive compensation and benefits package. Emerald BioStructures does not discriminate on the basis of race, color, religion, sex, age, marital status, national origin, disability, or status as a disabled, Vietnam-era, or other eligible veteran. Qualified candidates should send a resume and cover letter to jobs@embios.com.
[Post Date: January 09, 2012]
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Description:
The laboratories of Vanessa Ruta (The Rockefeller University) and Dr. Filippo Mancia (Columbia University Medical Center) are looking for a talented and highly motivated structural biologist for a postdoctoral position to work on a collaborative project to determine the structure and function of a sensory receptor. Ideally, the applicant should have extensive experience in protein biochemistry, crystallization and structure determination. Prior expertise in membrane protein biochemistry would be welcome but not required. Interested individuals should email their CV and names of references to ruta@rockefeller.edu and fm123@columbia.edu
[Post Date: January 04, 2012]
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TECHNICAL SUPPORT
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Tel: 949-425-1321
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Fax: 949-425-1611
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Email: tech@hrmail.com
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LOCATION
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Hampton Research
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34 Journey
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Aliso Viejo, CA 92656-3317
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Toll Free: 800-452-3899
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Tel: 949-425-1321
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Fax: 949-425-1611
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BUSINESS HOURS
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7:00 am to 5:00pm
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Monday - Friday
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(Pacific Standard Time)
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