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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Staff Scientist City of Hope
Website: https://chm.tbe.taleo.net/chm04/ats/careers/v2/viewRequisition?org=CITYOFHOPE&cws=40&rid=14640

City of Hope has a proven track record for translating our discoveries into life-saving medicines, playing a fundamental role in the development of recombinant insulin, humanization of monoclonal antibodies and CAR T cell therapies (with core patents covering each). The institute has over 27 core facilities with three FDA-approved/CA-licensed GMP facilities (small molecules, biologics and cellular therapies). Over the years, it has built a culture of communication between the clinicians and research faculty and a sense of urgency to treat and cure patients with cancer and diabetes.

The ideal candidate will be a self-starter that likes to work with other PIs across the institute. Projects that come to the core vary widely from de novo structure determination to protein-protein interactions to fragment screening and rational drug design. X-ray crystallography experience is absolutely required. Outstanding communication skills are also a must. The core houses a Rikagu 007HF, a mosquito crystallization robot, and two Formulatrix's imagers. In addition, the core has a Biacore T200, Water nanoITC, a Beckman XLI, Jasco 810 CD/fluorimeter and a Kinexa3000. All instruments are under vendor service contracts. The core also provides protein production using multiple expression systems as well as purification. The candidate will work closely with other core staff as well as other City of Hope cores involved with translational medicine (i.e., computational, HTS, synthetic chemistry, and mass spectrometry cores.)

City of Hope is located in Duarte, just a few miles away from Pasadena and close to all the major attractions of Los Angeles and Southern California, yet the campus is less than 10 minutes away from the San Gabriel mountains and numerous hiking trails (one as high as 10,000ft). The salary and benefits are highly competitive and the work is highly disciplinary.

[Post Date: September 19, 2018]

Title: Postdoc IGBMC

Two years full time postdoctoral position available in the laboratory of Elisa Bergamin, PhD., at the Institute of Genetic and Molecular and Cellular Biology (IGBMC) in Illkirch-Graffenstaden, near Strasbourg, in France.
We use a combination of cryo-electron microscopy, X-ray crystallography, biochemistry, and other functional assays to study the molecular mechanisms of action of the mammalian SWI/SNF protein complex with special attention to newly identified subunits.

We welcome highly qualified and motivated individuals with a Ph.D. training in structural biology (cryo-electron microscopy, X-ray crystallography) and/or protein biochemistry.
The ideal applicant will have experience with protein crystallography and cryoEM, molecular biology, and protein complex expression and purification. Although not a strict requirement, preference will be given to candidates with experience in single particle Cryo-EM. The position might also be of interest to people with experience in other structural biology areas (crystallography, NMR, computational modelling) that are eager to learn cryo-EM.

The IGBMC is a leading European research institute focused on understanding human disease and basic biological mechanisms at the molecular level. It counts several state-of-the-art technical facilities including the Titan Krios cryo electron microscope and a high throughput crystallization facility. It is a vibrant, international scientific community.

Please send your application (as a single pdf document) including cover letter, brief statement of prior research experience, a one-page statement of current research goals, CV, and contact information for three references to:

[Post Date: September 19, 2018]

Title: Senior Group Leader IIMCB

International Institute of Molecular and Cell Biology in Warsaw (Poland )is recruiting a senior group leader, an excellent mid-career investigator with a PhD degree, outstanding and transformative research accomplishments and demonstrated leadership experience.

IIMCB offers:
Group Leader position (professorial level) on an initially 5-year appointment with the possibility of extension, subject to external merit-based evaluation
• Research independence
• Highly competitive salaries for the PI and his/her team members
• Start-up funds
• Laboratory space and unlimited access to cutting-edge equipment
• Support in applications for additional grant funding
• Full technical, administrative and organizational support from professional English-speaking personnel

Applications should include:
• a cover letter explaining reasons for the application
• a Curriculum Vitae including a list of publications and grants
• a statement of scientific achievements (up to 1 page)
• a summary of the applicant’s future research plans (2 pages)
• contact details of two academic reference persons
• copies of three most important papers
Applications should be submitted by e-mail to ERAChairs@iimcb.gov.pl
Deadline: October 31st, 2018
The position is funded through the H2020 ERA Chairs project MOSaIC, Project ID: 810425

For more details please see:

[Post Date: September 14, 2018]

Title: Postdoc Kavli Institute

We invite applications for a postdoctoral fellowship in our lab at the Department of Bionanoscience, Kavli Institute of Nanoscience at Delft University of Technology.

Candidates are invited join a MC-COFUND program for early career researchers*. This provides opportunities for self-designed projects in line with the research interests of our lab and, if applicable, a second host lab with complementary expertise within the Kavli Institute or at our partner universities in Leiden and the Erasmus Medical Center.

Opportunities exist both for candidates with an interest in structural biology of in host-pathogen interactions and for candidates with an interest in computational method development.

The Kavli Institute of Nanoscience at TU Delft is an exciting place to work in an international, dynamic and collaborative environment with state-of-the-art facilities.

Delft is a friendly historic university city with a highly international population and a rich cultural scence, located at a short 30 min train ride from Schiphol International Airport with connections to almost any part in the world.

Come and join us!

If you are interested, please contact me by email (a.jakobi@tudelft.nl) letting me know why you would like to join us and attaching a CV. For more information see (http://cryoem.tudelft.nl).

[Post Date: September 13, 2018]

Title: Professorship Osnabrück University

Osnabrück University’s School of Biology/Chemistry invites applications for the following professorship to start as soon as possible.

Structural Biology (Bes.Gr. W3)

We are looking for an internationally renowned researcher with a future-oriented and independent focus in the field of structural biology with a focus on the function and dynamics of protein complexes on cellular structures. The research group's methodological expertise must be in the field of high-resolution methods such as cryo-electron microscopy (EM), EM tomography and/or X-ray structure analysis. In addition, competence in the analysis of membrane proteins and the interaction of proteins with membranes should be available.

The position holder should actively participate in current and planned research collaborations with the schools of biology/chemistry and physics such as the Collaborative Research Centre 944 (Physiology and Dynamics of Cellular Microcompartments) and new initiatives on the topics of "nanobiophotonics" and "evolutionary cell biology". Further requirements are an active participation in the interdisciplinary Center for Cellular Nanoanalytics in Osnabrück (CellNanOs) and a successful acquisition of third-party funding.

Questions regarding this position should be directed to Prof. Dr. Joost Holthuis, email: joost.holthuis@biologie.uni-osnabrueck.de)

[Post Date: September 12, 2018]

Title: Beamline Scientist Diamond Light Source
Website: https://vacancies.diamond.ac.uk/vacancy/senior-beamline-scientist-i04-362094.html

We are looking for a skilled and highly motivated Beamline Scientist for the macromolecular crystallography (MX) beamline I04 at Diamond Light Source.
I04 is a tuneable, microfocus capable X-ray beamline well equipped for high throughput MX and experimental phasing experiments supported by an active Research & Development programme. Recent upgrades include state of the art robotics and multi-axis goniometry and soon the beamline will take delivery of an Eiger2 16M detector. This is coupled with the ongoing move to fully automated data collections as part of its repertoire of user access modes.
Future upgrade paths will look into new ways of sample delivery and flexible experimental setups with complementary techniques that will enhance the current portfolio of available techniques and in particular the Beamline Scientist will take an active role in developing these on I04.

Further details and how to apply can be found here:


[Post Date: September 07, 2018]

Title: Junior Research Fellowships
Website: https://ntd-network.org

As part of GCRF Global Network in Neglected Tropical Diseases, which brings together groups from the UK, Latin America, India and Pakistan, we offer three Junior Research Fellowships to work on protozoan parasites. The fellowships are aimed at early-career researchers with some postdoctoral experience who want to establish their own research supported by a mentor of the Network in Durham. The research should align with the goals of the Network and can cober the areas of either molecular and cellular parasitology, chemicial biology or biochemistry and biophysics. The three-year fellowships are supported with generous funds for travel, consumables and acces to state-of-the art equipment in the Chemistry Department.

Further information about the participants of the network, our ethos and aims can be found here: https://ntd-network.org

A Global Network for Neglected Tropical Diseases ntd-network.org

The identification of reliable molecular targets for drug development is known to be challenging, with high rates of failure at the stage of validating potential candidates.
For further information and enquiries, please contact: ntd.network@durham.ac.uk
or for an informal chat, just contact: Ehmke.pohl@durham.ac.uk

[Post Date: September 07, 2018]

Title: Postdoc University of Alberta

The Department of Biochemistry, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta CANADA

Position Description:
The research group of Dr. Howard Young at the University of Alberta seeks a highly trained and motivated candidate for a postdoctoral fellow position. The broad interests of the labs are in membrane protein structure and function. We combine structural techniques such as macromolecular crystallography and cryo-EM with biophysical and biochemical methods such as membrane reconstitution and biophysical/functional assays to investigate the structural basis of membrane protein function and dysfunction in human diseases. The research projects available involve techniques such as biochemical and biophysical characterization of membrane transport proteins, X-ray crystallography, micro-electron diffraction (micro-ED), and cryo-EM of helical assemblies and single particle analysis.

The laboratories have state-of-the-art equipment and facilities. For X-ray crystallography, we access to an in-house MicroMax-007 HF X-ray system from Rigaku, a Gryphon crystallization robot, and periodic access to the Canadian Light Source synchrotron facility. My laboratory is also associated with the Centre for Prions and Protein Folding Diseases, which houses a Tecnai F20 electron microscope with a Falcon 2 direct electron detector and Gatan cryo-holders and cryo-transfer systems.

The candidates must hold a Ph. D. degree, be author of at least one first author publication and have a strong background in biochemistry or structural biology. Experience with basic molecular biology, protein expression, purification, and biochemical characterization are required. Prior experience in membrane protein biochemistry and bacterial/yeast expression systems for protein purification will be added advantages.

It is essential that the candidate be motivated and driven to achieve project goals. We promote a supportive team environment, and the ability to work as part of a cohesive group is important.

Edmonton is located in Alberta, Western Canada near the Canadian Rocky Mountains. The Canadian Rockies are one of the most beautiful regions of North America, with numerous opportunities for hiking, camping, fishing, canoeing, kayaking, and skiing. See the following URLs for additional information:

To apply:
Interested candidates can send an e-mail to Howard Young (hyoung@ualberta.ca) with a CV and a summary of previous research experience and future interests.

The University of Alberta is dedicated to equality, diversity, and inclusion in its training and employment programs.

[Post Date: September 07, 2018]

Title: Postdoc Positions Brown University

The Deaconescu Lab at Brown University has two openings for postdoc candidates. The laboratory's interests lie primarily in stress responses, with particular emphasis on responses to DNA damage and the mechanochemistry of DNA-based motors. We utilize a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, small-angle X-ray scattering, transmission electron microscopy). For examples of work, please see Vemu et al. Science (in press), Le TT et al. Cell (2018), Deaconescu et al. Photochemistry and Photobiology (2017), Kutter et al. JMB (2016), Szyk et al, Cell (2014), Deaconescu et al., PNAS (2012), Szyk et al., NSMB (2012) and Deaconescu et al., TIBS (2013).

A successful candidate should have an established track-record of publications in peer-reviewed journals; solid experience with protein biochemistry (including their purification from E.coli/yeast expression, functional characterization and assay development). Prior knowledge of crystallography and/or single-particle electron microscopy is highly desirable. Crystals/data at various stages of the structure determination process are available for immediate work. Must be highly motivated and work independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply.

Interested candidates should send a CV, one page research experience summary and contact information for three references to alexandra_deaconescu@brown.edu. Salary and starting date are negotiable. Please write Postdoctoral Candidate in the e-mail subject header. Brown University, an Ivy League school, is located less than one hour away by train from Boston. Lab webpage: https://deaconesculab.com

[Post Date: September 07, 2018]

Title: Postdoc Baylor College of Medicine

A Postdoctoral Fellowship position is available immediately in the group of Dr. Francis Tsai in the Department of Biochemistry at Baylor College of Medicine in Houston, TX. The Tsai lab uses structural analysis techniques at different resolution scales to understand the structure, function, and mechanism of protein quality control machines.

The successful applicant must be highly-motivated with experience in protein biochemistry and molecular biology, including gene cloning and protein expression. Methods used in the Tsai group range from structural analysis techniques, including but not limited to X-ray crystallography, single-particle cryoEM, and electron cryotomography, protein biochemistry, chemical biology, and proteomic approaches to using bacteria, yeast, and worms as model organisms. Experience with methods used for high-resolution structure analysis (X-ray, NMR, and cryoEM) is desirable but not required and training will be provided. Applicants should possess excellent written and verbal communication skills and should be within the first two years or their Ph.D. degree in a relevant field. Salary for this position is commensurate with experience and pegged to the current NIH scale.

To apply, please send your CV, description of research experience, and contact information for three referees to ftsai@bcm.edu. Further information may be found at the group's web site at https://www.bcm.edu/research/labs/francis-tsai.

[Post Date: September 03, 2018]

Title: Postdoc University of Nebraska-Lincoln

We are looking for a highly motivated scientist with a recent PhD degree in biochemistry, molecular biology, microbiology or a related field to join Prof. Limei Zhang’s research team at the Dept. of Biochemistry and the Redox Biology Center, University of Nebraska-Lincoln, USA (http://biochem.unl.edu). The research in the Zhang Laboratory focuses on structure-mechanism relationships of transcription factors involved in response to redox stress and virulence in bacterial pathogens. Multi-disciplinary approaches are used in the studies, including synchrotron-radiation-based X-ray diffraction, X-ray absorption spectroscopy, molecular biology and computational modeling. Experience in protein biochemistry, a demonstrated track record in conducting high quality research and a passion for learning new techniques are required. Experience in protein-DNA interaction in vivo and in vitro is highly desirable. The position offers competitive salary and benefits package.

The University of Nebraska-Lincoln is located in a vibrant and safe city offering outstanding and affordable quality of life, and numerous multi-cultural and entertainment benefits. The Redox Biology Center is organized as a broad-based interdisciplinary and multi-institutional entity involving researchers from the University of Nebraska-Lincoln and the University of Nebraska Medical Center in Omaha, and offers supportive and collaborative international environment as well as access to cutting edge proteomics, metabolomics, crystallography, and NMR facilities.

To apply for the position, please submit your curriculum vitae, the names and contacts of three references to limei.zhang@unl.edu.

[Post Date: September 03, 2018]

Title: Postdoc The Hospital for Sick Children

Job description
Dr. Julien’s laboratory at The Hospital for Sick Children Research Institute is looking for a Postdoctoral Fellow to join our Structural Biology team. The successful candidate will participate in the characterization of malaria antigens and antibodies by using a combination of biochemical, biophysical, immunological and structural techniques. We are looking for a driven and enthusiastic scientist who demonstrates passion and creativity towards the structure/function study of important pathogenic targets and who can thrive in a highly-collaborative setting.

Roles & Responsibilities
• Design and optimize constructs for expression in E.coli, insect cells (Sf9) and mammalian cells (HEK 293F);
• Determine X-ray crystal structures of antigens and antigen-antibody complexes;
• Use Electron Microscopy to screen constructs and to determine the molecular structures of antigen-antibody complexes.
• Perform protein engineering to develop immunogens using structure-based approaches.
• Biophysically characterize purified antigens for their Tm, Tagg and polydipersity;
• Perform ITC and BLI binding assays between antigens and purified antibodies to determine binding thermodynamics and kinetics.

Desired Skills and Experience
• Structural Biologist with a PhD in Biochemistry, Immunology, Molecular Biology, or related field;
• Experience in molecular biology, protein expression in various systems, purification and biophysical characterization (Octet, Optim, ITC, SEC-MALS);
• Strong knowledge in using structural biology to study pathogens and/or immune responses, especially in a context of structure-based vaccine design is a plus;
• Practical experience in using in silico approaches for protein engineering is a plus;
• Demonstrated ability to participate in collaborative scientific projects;
• Organization skills, efficiency and meticulous record keeping.

About Us
Dr. Julien's laboratory is interested in the structure/function study of B cell receptors and their interactions with antigens. A better understanding of the structures of B cell surface molecules will serve towards the rational design of improved vaccine immunogens against a variety of pathogens, including malaria and HIV-1. https://lab.research.sickkids.ca/julien/

We are located in The Peter Gilgan Centre for Research and Learning, a new 21-story, 750,000 square-foot facility that incorporates an open-concept design, state-of-the-art research facilities, and collaborative work spaces. As a member of the SickKids community, you will become part of a world-renowned organization dedicated to fulfilling a vision of Healthier Children, A Better World. For over 135 years, SickKids has worked hard to make the world a better place for children and their families. SickKids researchers have developed Pablum, discovered the gene for cystic fibrosis and are on the leading edge of research in a wide range of disciplines. Each day, people around the organization are doing meaningful work that directly, and often indirectly, benefits children in Canada and around the world.

Please apply before Oct. 15 by sending a CV and cover letter to: jean-philippe.julien@sickkids.ca. Anticipated start date in early/mid 2019.

[Post Date: September 03, 2018]

Title: EMBL Group Leader Heidelberg, Germany

Group Leader positions in in Cryo-EM and Systems Biology in the Structural and Computational Biology (SCB) Unit, EMBL Heidelberg, Germany.

Application closing date: 7 October 2018.
Interviews are planned for 22/23 November 2018.

The Structural and Computational Biology (SCB) Unit at EMBL Heidelberg seeks to recruit two outstanding group leaders to address fundamental questions in structural, molecular or cellular biology. One focus area is cryo-electron microscopy, whereby both single-particle analysis and/or electron tomography are of interest. Other areas, in which we are seeking creative leaders, are biochemistry, integrated structural biology, biophysics, chemical biology, proteomics or a mixture thereof to facilitate systemic approaches in structural biology, a concept that the unit is pursuing, in conjunction with a strong computational biology programme. The successful candidates will address fundamental biological or methodological questions and complement and synergize with existing activities of the SCB Unit. Further information on the position and how to apply can be found here:

The SCB Unit EMBL offers access to an outstanding integrated structural biology environment that includes a particularly well equipped cryo-electron microscopy facility housing several high end transmission electron microscopes including two Titan Krios and one Talos Arctica microscopes with direct detectors. Further information about research in the SCB Unit and at EMBL can be found at the EMBL web page:

In your online application, you will be asked to include a cover letter, CV and a concise description of research interests & future research plans. After submitting your application, you will be asked to invite 3 referees to provide their online reference, before the application closing date.

[Post Date: August 31, 2018]

Title: Postdoc Uppsala University

We’re currently looking to hire two postdoctoral researchers with a background in cryo-EM, X-ray crystallography, or single-molecule biophysics to join our ERC-funded research project at SciLifeLab Uppsala/Stockholm (deindl-lab.com).

Our group utilizes structural and single-molecule approaches to characterize the dynamics, structure, and regulation of chromatin-associated protein machines.

For more information, please see https://www.nature.com/naturejobs/science/jobs/650913-postdoctoral-position-in-structural-biology-or-single-molecule-biophysics.

[Post Date: August 31, 2018]

Title: Tenure-track Faculty Positions
Website: https://jobs.sciencecareers.org/previewjob/483453/assistant-associate-full-professor-structural-biology/

The Department of Biochemistry & Molecular Biology at the Indiana University
School of Medicine is seeking applications for tenure-track faculty positions
at the Assistant/Associate/Full Professor level positions in the area of
structural biology. This is broadly defined as experimental or computational
approaches to determining the underlying structural basis for the function of
macromolecules or macromolecular assemblies. The Department currently has
strengths in X-ray crystallography and NMR and will consider applicants in
these areas of expertise as well as those with complementary expertise in
other imaging methods such as cryoEM or in computational areas. The
Departmental culture values a collaborative working environment and places a
strong emphasis on mentoring. More information about the sponsoring unit can
be found at:

Successful applicants are expected to have/develop a strong, independent
extramurally funded research program, participate in training students and
fellows, and engage in research interactions with the clinical programs
complementary to their scientific interests. A competitive salary, startup
funds, and space will be provided.

Interested individuals should submit a Curriculum Vitae, cover letter, summary
of past accomplishments and future research plans, and the names and contact
information for 3-5 references in electronic format at
http://indiana.peopleadmin.com/postings/6164. The search committee will begin
considering applications immediately and on an on-going basis until positions
are filled. Questions can be directed to biomfac@iupui.edu.

We encourage applications from women and other underrepresented groups as
Indiana University is strongly committed to achieving excellence through
cultural diversity. In addition, it is the University's policy to provide
reasonable ADA accommodations for qualified persons with disabilities.
Candidates must be sensitive to the needs of and possess an interest in
working in an academic community that is diverse with regard to gender, race,
color, ethnicity, nationality, sexual orientation or identity, disability
status, protected veteran status, and religion. Indiana University is an
EEO/AA Employer, M/F/D.

[Post Date: August 24, 2018]
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