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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Postdoc University of Chicago

Postdoctoral Position in Cellular Communication

Applications are invited for an immediate opening at the Cellular Communication Group with Dr. Demet Araç, at the Department of Biochemistry and Molecular Biology, University of Chicago (http://arac.uchicago.edu).

We are interested in understanding how cellular communication in the nervous system is mediated by adhesion molecules on cell surfaces and how cell-cell interactions regulate cellular signaling at the molecular level. The following papers describe the current direction of our research program:

· Structural basis for teneurin function in circuit-wiring: A toxin motif at the synapse. Li, Shalev-Benami, Sando,…, Südhof, Skiniotis, Araç. Cell (2018)
· Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region. Salzman, Zhang, …, Koide, Araç. PNAS (2017)
· Structural basis for regulation of GPR56/ADGRG1 by its alternatively spliced extracellular domains. Salzman, Ackerman , … , Koide, Araç. Neuron (2016)
· Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Lu, Nazarko, … , Südhof, Araç. Structure (2015)

Applications from a range of backgrounds including biochemistry, molecular biology, and cell biology are invited. Required skills include cell culture, molecular cloning and protein biochemistry. Experience in protein expression/purification, structure determination, and GPCR signaling pathways are a plus.

Our laboratory is located at the University of Chicago, and is affiliated with the Department of Biochemistry and Molecular biology (http://bmb.uchospitals.edu/) and the Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior (http://neuroscience.uchicago.edu/grossman-institute/). The researcher recruited through this project will have the opportunity to visit and collaborate with interdisciplinary scientists on campus (https://www.uchicago.edu/).

Highly motivated candidates with a strong track record of publications should send an application package with research interests, full CV with experimental skills listed in detail, names and contact information of 3 references to Demet Araç (arac AT uchicago.edu).

The University of Chicago is an Affirmative Action/Equal Opportunity/Disabled/Veterans Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status or status as an individual with disability.

[Post Date: April 20, 2018]

Title: Postdoc University of California, Irvine

One postdoctoral position is available in Dr. Rongsheng Jin’s laboratory at the Department of Physiology and Biophysics, University of California Irvine (Irvine, California, USA). The new postdoctoral fellow is expected to participate in NIH-supported projects focusing on the mechanism of action of bacterial virulence factors in their cellular context (Science 2012, PLOS Pathogens 2013, Science 2014, NSMB 2016, Science 2018). Our laboratory employs a multidisciplinary approach that combines X-ray crystallography, SAXS, electron microscopy with the more traditional approaches of biochemistry and biophysics. We have also built long-standing collaborative relationships in the areas of cell biology, electrophysiology, toxicology, and animal studies. The successful candidates should have a Ph.D. degree, high motivation, and strong background in one or more of the following research areas: biochemistry, biophysics, molecular biology and structural biology. Applicants please send their curriculum vitae and names of three referees to r.jin@uci.edu.

[Post Date: April 19, 2018]

Title: Staff Scientist, Ulm University
Website: https://tinyurl.com/y7u8a7s9

Title: Staff Scientist at Ulm University, Germany

The recently founded Institute of Pharmaceutical Biotechnology at the Ulm University is searching to fill the following position as soon as possible:
Staff Scientist for our X-ray crystallography platform

Your responsibilities are:
Establishment and supervision of the X-ray crystallography platform
Management of projects from our institute and our collaboration partners
Robot-assisted and manual crystallization trials of proteins and protein-RNA complexes
Data collection at synchrotrons, including organization of beam-time applications
Data processing and structure determination
Analyses of protein complexes with biophysical techniques (ITC, Biacore, SLS, DLS...)
Protein purification by FPLC/HPLC
Participation in teaching and lab management of the institute

Your profile:
Successfully finished studies and PhD degree in the areas of Biology, Biochemistry,
Structural Biology, Biophysics, or related topics
Solid expertise in solving protein crystal structures via MR and SAD/MAD
Expertise in quantitative biophysical interaction studies
Experience in electron microscopy is of advantage, but no must
Excellent command in spoken and written English and German

Please send your application (quoting job post #50) until May 6th, 2018 to Dr. Dierk Niessing (dierk.niessing@uni-ulm.de), Institute of Pharmaceutical Biotechnology, Ulm, Germany. For enquiries about this position please also contact Dierk Niessing.

The application should contain a motivation letter, CV, publication list, short description of research, and names of people who are willing to provide a recommendation for you.

Salary is based on the German Public Service Level TV-L E13. We are committed to increase the share of woman and therefore encourages female candidates to apply. Physically disabled applicants receive favorable consideration when equally qualified. The appointment is made by the central university administration.

Please find the official job post (#50) at: https://www.uni-ulm.de/universitaet/karriere/
Institute’s homepage: https://www.uni-ulm.de/pharmbio

[Post Date: April 19, 2018]

Title: Postdoc/Research Associate Biochemistry

Postdoctoral Fellow / Research Associate – Biochemistry

Jian Jin lab - Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, - New York, NY

The Jian Jin lab (http://labs.icahn.mssm.edu/jinlab/) specializes in Medicinal Chemistry, Chemical Biology & Drug Discovery. We have an immediate opening for a Postdoctoral Fellow / Research Associate in the biochemistry part of the lab, which is integrated with the medicinal chemistry part of the lab, to discover novel therapeutics. We invite highly skilled and motivated biochemists who are interested in expanding or deepening their skills including small-molecule drug discovery and chemical biology to apply for this position.

The postdoctoral fellow / research associate will work on cutting-edge drug discovery and/or chemical biology projects. The primary responsibilities of postdoctoral fellow / research associate include: (1) protein expression and purification, (2) developing biochemical/biophysical assays, and (3) testing compounds in these assays. The fellow will become a member of multidisciplinary teams in an environment where his/her knowledge and skills of biochemistry will play a critical role in advancing the drug discovery and/or chemical biology projects.

Educational Requirements: A Ph.D. degree in biochemistry, biophysics, structural biology or a related area.

Qualifications and Experience: Qualified applicants must have extensive experience in protein expression and purification. Candidates should possess excellent laboratory and communication skills and demonstrate a strong level of independence, self-motivation, and work ethic. Knowledge of x-ray crystallography is preferred, but not required.
Please e-mail a cover letter, CV and contact information with two reference letters to Dr. Nicolas Babault (nicolas.babault@mssm.edu).

[Post Date: April 12, 2018]

Title: Research Associate/Assistance Professor

Research Associate/Assistant Professor positions are immediately available in Prof. Ian Wilson’s Lab of Antibody Structure at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University (http://siais.shanghaitech.edu.cn/eng/research7.asp). SIAIS is an innovative research institute dedicated to the fundamental problems in life science, particularly in the field of immunology.

The Lab of Antibody Structure utilizes a multidisciplinary approach to study the structures and functional mechanisms of key molecules/complexes in innate and adaptive immunity, with a long-term goal of understanding and modulating the functions of important immune receptors and effectors for the prevention and treatment of various immune disorders, microbial infections or cancers.
We are now seeking self-motivated talents to join us. Candidates for Research Associate/Assistant Professor positions should:

--- hold a Ph.D. degree in biophysics, biochemistry, computational biology or immunology
--- have a strong research background in structural or computational biology
--- have a publication record commensurate with experience
--- manifest good problem solving, interpersonal and communication skills
--- familiarity with single particle electron microscopy of macromolecular complexes would be a big plus
--- experience in membrane protein crystallography would also be a plus, as well as familiarity with small angle x-ray scattering (SAXS)

Besides taking responsibilities for his/her own and collaborative projects, the candidates are also expected to help training and supervising graduate students and postdoctoral fellows. The candidates will benefit from the world-class academic environment as well as easy access to SSRF beam lines for macromolecules and SAXS, and state-of-the-art cryo-EM instruments (Titan Krios/K2 to be installed at ShanghaiTech University).

If interested, please send a cover letter, a curriculum vitae with publication list and three references to siais@shanghaitech.edu.cn (cc: wilson@scripps.edu and yangbei@shanghaitech.edu.cn). Title and Salary will be commensurate with experience. The positions remain open until filled.

[Post Date: April 12, 2018]

Title: Postdoc Washington University in St. Louis

Applications are invited for a joint postdoctoral position in the Medical School of Washington University in St. Louis. Washington University has a tradition of excellence in medical science and a stimulating academic environment. Weikai Li and Jianmin Cui labs study the structural biology and electrophysiology of various membrane proteins including ion channels. The postdoctoral research will involve the structural determination of these integral membrane proteins using cryo-EM and X-ray crystallography techniques. Applicants should have expertise in membrane protein biology or structural biology. The labs are well funded and have great facilities, including access to a state-of-art Titan Krios, available to support these researches. Please send a CV and reference letters to weikai@wustl.edu. More information can be found at http://www.biochem.wustl.edu/faculty/li.html and https://research.engineering.wustl.edu/~jcui/index.html.

[Post Date: April 11, 2018]

Title: Postdoc VUB, Brussels
Website: http://www.vib.be/en/research/scientists/Pages/Joris-Messens-Lab.aspx

Postdoctoral position in redox signaling kinetics

Position: A postdoctoral Research position is immediately available for structure-function studies of proteins involved in redox metabolite signaling. Successful candidates will join an exciting research environment of the Messens VIB-laboratory at the Center for Structural Biology in Brussels. The Messens laboratory is recognized as a world leader in the redox field, and the lab provides an outstanding position in protein biochemistry and structural biology, in a highly dynamic and team-oriented research group. In this cutting-edge research environment, you will tackle essential biological problems in metabolite signaling.

Mission of the lab: We decipher how cells sense redox metabolites and transduce stimuli into downstream biological effects. Knowledge of the mechanisms by which sensors and transducers function are invaluable in understanding how redox homeostasis pathways can be engineered with the ultimate goal to improve oxidative stress resistance in plants and to identify therapeutic targets in redox diseases.

Your function in the lab: You will be involved in a project that exploits prokaryotic proteins for the design of de novo biosensors with a fluorescent read-out useful for both in vitro studies and live imaging of cellular metabolic changes. Further, your expertise will be needed for the structural and functional analysis of plant redox sensors to understand how organelle communication functions at the molecular level.

Requirements: Applicants should have obtained a PhD in the last 5 years within the field of protein biochemistry and should have hands-on expertise with protein purification and fast kinetic techniques. Fluency in English is a must. Experience with biophysical techniques and structural biology is a plus, but not required.

Please send a cover letter discussing your interests in the laboratory and the project as well as your CV and a list of 3 individuals as references to joris.messens@vib-vub.be.

[Post Date: April 11, 2018]

Title: Postdoc University of Toronto

A postdoctoral position is immediately available in the group of Jinrong Min in the Structural Genomics Consortium at the University of Toronto. My lab aims to characterize protein-protein, protein-DNA and protein-RNA complexes by X-ray crystallography in combination with other biochemical and biophysical techniques. More details about our research can be found at the http://www.sgc.utoronto.ca/Chromatin or https://www.ncbi.nlm.nih.gov/pubmed/?term=min%20jinrong.

Applicants should have a Ph.D. in structural biology, biochemistry, or molecular/cell biology with 0-3 years postdoctoral research experience. Interested candidates are invited to send their CV with 3 references to Dr. Jinrong Min by email: jr.min@utoronto.ca.

[Post Date: April 10, 2018]

Title: Postdoc Genentech
Website: https://tinyurl.com/y7xylfg7

Title: Postdoctoral Research Fellow, Structural Biology, Matsumoto Lab, Genentech

Website: https://www.gene.com/careers/detail/3597728305/Postdoctoral-Research-Fellow-Structural-Biology-Matsumoto-Lab-Genentech-Research

Description: The Matsumoto lab, within the Structural Biology Department at Genentech, is seeking an innovative postdoctoral research fellow to pursue protein engineering and structural characterization of novel immunoglobulins for basic research and potential therapeutic applications. The lab has an extensive history and active research program focused on developing antibodies to detect complex ubiquitin post-translational modifications (PTMs). The postdoctoral fellow will use in vitro directed evolution methods paired with X-ray crystallography to select antibody fragments to PTMs of interest, structurally characterize their interactions, and optimize affinity and specificity. In addition, the postdoctoral fellow will explore structural characterization of novel immunoglobulin-like formats currently being investigated as potential therapeutic platforms. The successful candidate will spearhead all aspects of his/her projects including protein expression and purification, biochemical synthesis of complex PTMs, antibody engineering, and X-ray crystallography (or potentially cryo-EM, as applicable) to structurally characterize selected antibodies and immunoglobulin-like molecules. Our department has state-of-the-art crystallography and cryo-EM facilities along with access to multiple directed evolution platforms. This is a unique opportunity to purse a postdoctoral research fellowship focused on cutting-edge technology development and publication-oriented research in a highly collaborative, industrial setting.

For more information on the Matsumoto Lab and publications, please visit: https://www.gene.com/scientists/our-scientists/marissa-matsumoto

For more information on the Genentech Postdoctoral Program, please visit: http://www.gene.com/careers/academic-programs/postdocs

Applicants should apply by submitting a curriculum vitae (CV), brief statement of research experience and interests, as well as 3 contacts for references letters via this link: https://www.gene.com/careers/detail/3597728305/Postdoctoral-Research-Fellow-Structural-Biology-Matsumoto-Lab-Genentech-Research

The successful candidate will be a highly motivated and detail-oriented researcher, driven to solve complex scientific problems, and able to work both independently and in a collaborative environment. Candidates must have a Ph.D. in structural biology, biochemistry, molecular biology, or a related field. Expertise in protein purification, characterization, crystallization, and X-ray structure determination is required, as evidenced by at least one first author publication or accepted manuscript in a peer-reviewed journal. Experience in protein engineering and directed evolution techniques (e.g. phage, yeast, ribosome, and/or mRNA display) is a plus, but not required. However, a strong desire to become well versed in these techniques is a must.

[Post Date: April 10, 2018]

Title: Postdoc EMBL Grenoble
Website: https://www.embl.de/jobs/searchjobs/index.php?ref=GR_00121&newlang=1&pos%5b%5d=0&loc%5b%5d=0

PostDoc Position at EMBL Grenoble, Structural Biocomputing

We have an opening for a post-doc in Structural Biocomputing at EMBL Grenoble. The successful candidate will be working towards implementing advanced data analysis in the context of fragment screening and X-ray crystallography pipelines in Grenoble based on the CrystalDirect technology. This project will be carried out in collaboration with Kleywegt, Velankar and Leach groups from the European Bioinformatics Institute (EBI, Hinxton). Applications should be submitted through the www.embl.de/jobs/ portal.


Deadline for applications is May 6th.

[Post Date: April 09, 2018]

Title: Postdoc Oulu, Finland
Website: https://www.saimanet.com/certiahome/open_job_view.html?id=00005405

University of Oulu, position open for a postdoctoral researcher in a team focusing on structural biology and drug discovery. Information on our team and projects can be found from our web pages: http://www.oulu.fi/biocenter/groups/lehtio

More details regarding the position can be found in the following link. Application forms are available also through the link and applications are accepted only through the web-based system.


[Post Date: April 06, 2018]

Title: Protein Chemist/Structural Biologist
Website: https://www.wehi.edu.au/research-officer-cowman-laboratory

About the position
The postdoctoral scientist who fills this position will be an expert in protein science and structural biology to work as part of a team within the Cowman laboratory to express proteins in a functional form. The position requires experience in protein expression, purification and characterization and a strong background in structural biology. The appointee will collaborate within a team environment on a project funded by the Wellcome Trust and in collaboration with Merck USA that is aimed towards the development of new antimalarial drugs.

Key Responsibilities
Technical Service – Protein Science
· Design and assemble DNA constructs for protein expression in bacteria, yeast, insect and mammalian systems.
· Express and purify proteins in bacteria, yeast, insect and mammalian cells.
· Characterize recombinant proteins (MS, ITC, SPR, CD, enzyme kinetics etc.)
· Crystallize proteins for structural studies by X-ray diffraction.
· Accurate and timely completion of tasks to enable the project to meet deadlines
· Source and read the literature relevant to the project
· Composition of figures and methods data for publications.
· Carefully maintain laboratory records with a particular awareness of IP issues
· Assist in maintaining the laboratory in a clean, well-stocked, safe and orderly state.

Selection Criteria
Personal qualities
· Strong work ethic, capacity to work independently or as part of a team, ability to troubleshoot experimental problems, willingness to aid students, good record-keeping with meticulous attention to detail.
Knowledge and skills
· PhD in protein science (biochemistry, structural biology, synthetic biology etc.)
· Experience in protein expression (bacterial and eukaryotic systems), purification (IMAC, SEC, IEX, HIC), and characterization (MS, ITC, SPR, CD, enzyme kinetics etc).
· Experience in determining protein structures by X-ray crystallography.
· Sound communication skills (both oral and written English)
Terms of appointment
The position is available for a period of 2 years in the first instance. Up to 17% superannuation and very attractive salary packaging options are available.
A position description is available.
General enquiries can be directed to Professor. Alan Cowman.

How to apply
Please email your application including cover letter, CV and a letter addressing the key selection criteria in pdf format to jobapplications@wehi.edu.au quoting reference WEHI/CAAC in the subject line.

At the Walter and Eliza Hall Institute we strive to ensure our staff and students enjoy a great working environment. We value diversity and gender equity in our work force and promote flexible working arrangements for staff to balance working requirements and personal needs. We have implemented a number of gender equity initiatives to support female laboratory heads.

[Post Date: April 06, 2018]

Title: Postdoc Uppsala University
Website: http://uu.se/en/about-uu/join-us/details/?positionId=199363

Postdoctoral researcher at the Department of Cell and Molecular Biology, Uppsala University.

The project aims to study the structure and function of metal-responsive transcription factors. The successful candidate should have an excellent track record and experience in X-ray crystallography as well as protein expression and purification. Experience of complementary techniques in biochemistry and biophysics would be a benefit.

[Post Date: April 03, 2018]

Title: Postdoc Structural Biology UCSF

Postdoctoral Position: Structural Biology of Host-Pathogen Conflict

There is a post-doctoral position available in the laboratory of John Gross at UCSF. The basic science question is how structural adaptation in viral suppressors of innate immunity allowed cross-species transmission and the origin of modern pandemics such as AIDS. The position is NIH funded for several years. Candidates will have expertise in X-ray crystallography and quantitative biochemistry of macromolecular complexes. Experience with eukaryotic protein expression systems is desirable.

The Gross lab is part of the HARC center (https://harc.ucsf.edu/) and the Macromolecular Structure Group (http://www.msg.ucsf.edu/) at UCSF. This strong collaborative environment will allow the applicant to integrate structural and biochemical studies with evolutionary analysis and molecular virology.

Applications materials, including CV and contact information for three references should be sent to jdgross@cgl.ucsf.edu with “post-doc position” written in subject line.

[Post Date: April 02, 2018]

Title: Postdoc AstraZeneca
Website: https://job-search.astrazeneca.com/job/gothenburg/post-doc-fellow-cryoem-structural-biology-of-protein-complexes/7684/7417154

AstraZeneca has an opening for a Post-Doc Fellow in CryoEM/Structural biology at AstraZeneca in Gothenburg. The aim of the project is to study multi-protein complexes of relevance for cellular signaling. The project will be a collaboration with Dr. Alexey Amunts at SciLifeLab, Stockholm University.

For more information about the position and how to apply, visit the web site link above.

[Post Date: March 29, 2018]

Title: Postdoc University of Lausanne

Postdoctoral Position: Structural and mechanistic characterization of Cell
wall signaling cascades at the University of Lausanne, Switzerland

Prof. Julia Santiago at the University of Lausanne, Switzerland, is looking for a postdoctoral fellow to dissect cell wall signaling pathways in mechanistic detail. The position is available from July 2017 until filled.

Who we are and what we are interested in: We are an ERC Starting Grant-funded lab with a key interest in plant development and plant signaling cascades. In particular, we would like to understand how plants sense chemical and mechanical changes in the cell wall, and how they integrate this information inside the cell to regulate growth, shape and protection. The group combines structural biology (X-ray protein crystallography) and quantitative biochemistry with genetics and cell biology in the model plant Arabidopsis thaliana. We are offering a dynamic and dedicated research environment with state-of-the art facilities for structural biology, biochemistry,(eukaryotic expression platform, biophysical instrumentation and access to a crystallization facility), plant genetics and cell biology. Our research is focused on cell signaling and cell wall remodeling events (Santiago et al., EMBO J, 2011; Santiago, Henzler & Hothorn, Science, 2013; Santiago et al., eLife, 2016) essential to plant growth and development. Our lab is located at the University of Lausanne at the Dorigny Campus, by the lake Geneva, in Lausanne.

Your profile: You are a recent (less than 2 year) PhD graduate in structural biology or biochemistry with a keen interest in signal transduction. You have a good working knowledge of protein biochemistry (eukaryotic protein expression, purification, characterization), structural biology (protein crystallization, structure determination) and an interest in learning new methods and skills. Your are fluent in English (both written and oral) and your have demonstrated your scientific abilities by at least one 1st author publication in a peer-reviewed structural biology/biochemistry journal. We are seeking a creative, self-
motivated team-player that will integrate with the other plant biologists in the group. Suitable candidates will be encouraged to apply for fellowships, but internal funding is available.

We offer: A postdoctoral position (for up to 5 years) in a friendly, international and interdisciplinary working environment with possibilities of continuous training in different techniques.

Contact: Please direct applications (consisting of a letter of intent, your CV, and names of 2-3 referees) and informal inquiries to Julia Santiago (julia.santiago@unil.ch).

[Post Date: March 26, 2018]

Title: Postdoc Brown University

The Deaconescu Lab at Brown University is seeking a postdoctoral researcher. We are an enthusiastic group of biochemists and structural biologists with a strong interest in the function, mechanochemistry and regulation of DNA-based motors. We utilize using a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, small-angle X-ray scattering, transmission electron microscopy). For examples of work in these areas, please see Le TT et al, Cell (2018), Deaconescu et al, Photochemistry and Photobiology (2017), Kutter et al, JMB (2016), Szyk et al, Cell (2014), Szyk et al., NSMB (2012), Deaconescu et al., PNAS (2012), and Deaconescu et al., TIBS (2013). A successful candidate should have the following qualifications: a Ph.D. in the field of Molecular Biology, Cell Biology, Biochemistry or related field; an established track-record of publications in peer-reviewed journals; solid experience in the biochemistry of complex DNA-binding proteins (such as chromatin remodeling factors or DNA repair proteins), their purification from E.coli/yeast expression systems as well as their characterization using functional studies such as by isothermal titration calorimetry and fluorescence. Prior knowledge of crystallography would be a plus, but is not required. We are well equipped for biochemical and crystallographic work ( with an in-house X-ray generator and crystallization robots, multiple fplc systems etc) and will soon be equipped with the instruments needed for electron microscopy specimen preparation as well.

Candidate must be highly motivated and work independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply. Salary and starting date are negotiable. For more information about the lab, visit https://deaconesculab.com. Interested candidates should send a CV, one page research experience summary and contact information for three references to alexandra_deaconescu@brown.edu. Salary and starting date are negotiable. Please write Postdoctoral Candidate in the e-mail subject header. Brown University, an Ivy League school, is located less than one hour away by train from Boston.

[Post Date: March 23, 2018]
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